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1. Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults

Author

Bosch de Basea Gomez, Magda, Thierry-Chef, Isabelle, Harbron, Richard, Hauptmann, Michael, Byrnes, Graham, Bernier, Maria-Odile, Le Cornet, Lucian, Dabin, Jérémie, Ferro, Gilles, Istad, Tore S., Jahnen, Andreas, Lee, Choonsik, Maccia, Carlo, Malchair, Françoise, Olerud, Hilde, Simon, Steven L., Figuerola, Jordi, Peiro, Anna, Engels, Hilde, Johansen, Christoffer, Blettner, Maria, Kaijser, Magnus, Kjaerheim, Kristina, Berrington de Gonzalez, Amy, Journy, Neige, Meulepas, Johanna M., Moissonnier, Monika, Nordenskjold, Arvid, Pokora, Roman, Ronckers, Cecile, Schüz, Joachim, Kesminiene, Ausrele, and Cardis, Elisabeth

Published
2023
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2. Sweetened beverages are associated with a higher risk of differentiated thyroid cancer in the EPIC cohort: a dietary pattern approach

Author

Zamora-Ros, Raul, Cayssials, Valerie, Clèries, Ramon, Torrents, Maria, Byrnes, Graham, Weiderpass, Elisabete, Sandström, Maria, Almquist, Martin, Boutron-Ruault, Marie-Christine, Tjønneland, Anne, Kyrø, Cecilie, Katzke, Verena A., Le Cornet, Charlotte, Masala, Giovanna, Krogh, Vittorio, Iannuzzo, Gabriella, Tumino, Rosario, Milani, Lorenzo, Skeie, Guri, Ubago-Guisado, Esther, Amiano, Pilar, Chirlaque, María-Dolores, Ardanaz, Eva, Janzi, Suzanne, Eriksson, Linda, Freisling, Heinz, Heath, Alicia K., Rinaldi, Sabina, and Agudo, Antonio

Published
2023
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3. Brain cancer after radiation exposure from CT examinations of children and young adults: results from the EPI-CT cohort study

Author

Hauptmann, Michael, Byrnes, Graham, Cardis, Elisabeth, Bernier, Marie-Odile, Blettner, Maria, Dabin, Jérémie, Engels, Hilde, Istad, Tore S, Johansen, Christoffer, Kaijser, Magnus, Kjaerheim, Kristina, Journy, Neige, Meulepas, Johanna M, Moissonnier, Monika, Ronckers, Cecile, Thierry-Chef, Isabelle, Le Cornet, Lucian, Jahnen, Andreas, Pokora, Roman, Bosch de Basea, Magda, Figuerola, Jordi, Maccia, Carlo, Nordenskjold, Arvid, Harbron, Richard W, Lee, Choonsik, Simon, Steven L, Berrington de Gonzalez, Amy, Schüz, Joachim, and Kesminiene, Ausrele

Published
2023
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5. Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors.

Author

George, Julie, Walter, Vonn, Peifer, Martin, Alexandrov, Ludmil B, Seidel, Danila, Leenders, Frauke, Maas, Lukas, Müller, Christian, Dahmen, Ilona, Delhomme, Tiffany M, Ardin, Maude, Leblay, Noemie, Byrnes, Graham, Sun, Ruping, De Reynies, Aurélien, McLeer-Florin, Anne, Bosco, Graziella, Malchers, Florian, Menon, Roopika, Altmüller, Janine, Becker, Christian, Nürnberg, Peter, Achter, Viktor, Lang, Ulrich, Schneider, Peter M, Bogus, Magdalena, Soloway, Matthew G, Wilkerson, Matthew D, Cun, Yupeng, McKay, James D, Moro-Sibilot, Denis, Brambilla, Christian G, Lantuejoul, Sylvie, Lemaitre, Nicolas, Soltermann, Alex, Weder, Walter, Tischler, Verena, Brustugun, Odd Terje, Lund-Iversen, Marius, Helland, Åslaug, Solberg, Steinar, Ansén, Sascha, Wright, Gavin, Solomon, Benjamin, Roz, Luca, Pastorino, Ugo, Petersen, Iver, Clement, Joachim H, Sänger, Jörg, Wolf, Jürgen, Vingron, Martin, Zander, Thomas, Perner, Sven, Travis, William D, Haas, Stefan A, Olivier, Magali, Foll, Matthieu, Büttner, Reinhard, Hayes, David Neil, Brambilla, Elisabeth, Fernandez-Cuesta, Lynnette, and Thomas, Roman K

Subjects
Humans, Neuroendocrine Tumors, Carcinoma, Neuroendocrine, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Immunohistochemistry, In Situ Hybridization, Fluorescence, DNA Mutational Analysis, Genomics, Small Cell Lung Carcinoma, High-Throughput Nucleotide Sequencing, In Vitro Techniques, Carcinoma, Neuroendocrine, Non-Small-Cell Lung, In Situ Hybridization, Fluorescence
Abstract

Pulmonary large-cell neuroendocrine carcinomas (LCNECs) have similarities with other lung cancers, but their precise relationship has remained unclear. Here we perform a comprehensive genomic (n = 60) and transcriptomic (n = 69) analysis of 75 LCNECs and identify two molecular subgroups: "type I LCNECs" with bi-allelic TP53 and STK11/KEAP1 alterations (37%), and "type II LCNECs" enriched for bi-allelic inactivation of TP53 and RB1 (42%). Despite sharing genomic alterations with adenocarcinomas and squamous cell carcinomas, no transcriptional relationship was found; instead LCNECs form distinct transcriptional subgroups with closest similarity to SCLC. While type I LCNECs and SCLCs exhibit a neuroendocrine profile with ASCL1high/DLL3high/NOTCHlow, type II LCNECs bear TP53 and RB1 alterations and differ from most SCLC tumors with reduced neuroendocrine markers, a pattern of ASCL1low/DLL3low/NOTCHhigh, and an upregulation of immune-related pathways. In conclusion, LCNECs comprise two molecularly defined subgroups, and distinguishing them from SCLC may allow stratified targeted treatment of high-grade neuroendocrine lung tumors.

Published
2018

6. Cancer mortality in chrysotile miners and millers, Russian Federation: main results (Asbest Chrysotile Cohort-Study)

Author

Schüz, Joachim, primary, Kovalevskiy, Evgeny V., additional, Olsson, Ann, additional, Moissonnier, Monika, additional, Ostroumova, Evgenia, additional, Ferro, Gilles, additional, Feletto, Eleonora, additional, Schonfeld, Sara J., additional, Byrnes, Graham, additional, Tskhomariia, Iraklii M., additional, Straif, Kurt, additional, Morozova, Tatiana V., additional, Kromhout, Hans, additional, and Bukhtiyarov, Igor V., additional

Published
2024
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8. Cancer mortality in chrysotile miners and millers, Russian Federation: main results (Asbest Chrysotile Cohort-Study).

Author

Schüz, Joachim, Kovalevskiy, Evgeny, Olsson, Ann, Moissonnier, Monika, Ostroumova, Evgenia, Ferro, Gilles, Feletto, Eleonora, Schonfeld, Sara J, Byrnes, Graham, Tskhomariia, Iraklii, Straif, Kurt, Morozova, Tatiana, Kromhout, Hans, and Bukhtiyarov, Igor

Subjects
CANCER-related mortality, CHRYSOTILE, LUNG cancer, CANCER patients, POISSON regression
Abstract

Background We investigated mortality in workers of the world's largest chrysotile mine and enrichment factories located in the town of Asbest, Russian Federation. Methods This historical cohort study included all workers employed for at least 1 year between 1975 and 2010 and follow-up until the end of 2015. Cumulative exposure to dust was estimated based on workers' complete occupational history linked to dust measurements systematically collected from the 1950s. Exposure to chrysotile fibers was estimated using dust-to-fiber conversion factors. Relative risks (RRs) and 95% confidence intervals (CIs) were estimated as mortality rate ratios in Poisson regression models. Results A total of 30 445 (32% women) workers accumulated 721 312 person-years at risk and 11 110 (36%) died. Of the workers, 54% had more than 30 years since their first exposure. We found an exposure-response between cumulative dust and lung cancer mortality in men. No clear association with dust exposure but a modest increase in the highest category of fiber exposure was seen for lung cancer in women. Mesothelioma mortality was increased (RR = 7.64, 95% CI = 1.18 to 49.5, to at least 80 fibers per cm3 years and RR = 4.56, 95% CI = 0.94 to 22.1, to at least 150 mg/m3 years [dust]), based on 13 deaths. For colorectal and stomach cancer, there were inconsistent associations. No associations were seen for laryngeal or ovarian cancer. Conclusion In this large-scale epidemiological study in the world's largest active asbestos mine, we confirmed an increased risk of mesothelioma with high fiber exposure and an increasing mortality for lung cancer in men with increasing dust exposure. Less clear-cut increased lung cancer mortality was seen in the women. Continued mortality follow-up is warranted. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Circulating tumour-derived KRAS mutations in pancreatic cancer cases are predominantly carried by very short fragments of cell-free DNA

Author

Zvereva, Maria, Roberti, Gabriel, Durand, Geoffroy, Voegele, Catherine, Nguyen, Minh Dao, Delhomme, Tiffany M., Chopard, Priscilia, Fabianova, Eleonora, Adamcakova, Zora, Holcatova, Ivana, Foretova, Lenka, Janout, Vladimir, Brennan, Paul, Foll, Matthieu, Byrnes, Graham B., McKay, James D., Scelo, Ghislaine, and Le Calvez-Kelm, Florence

Published
2020
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10. Main nutrient patterns are associated with prospective weight change in adults from 10 European countries

Author

Freisling, Heinz, Pisa, Pedro T, Ferrari, Pietro, Byrnes, Graham, Moskal, Aurelie, Dahm, Christina C, Vergnaud, Anne-Claire, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Cadeau, Claire, Kühn, Tilman, Neamat-Allah, Jasmine, Buijsse, Brian, Boeing, Heiner, Halkjær, Jytte, Tjonneland, Anne, Hansen, Camilla P, Quirós, J Ramón, Travier, Noémie, Molina-Montes, Esther, Amiano, Pilar, Huerta, José M, Barricarte, Aurelio, Khaw, Kay-Tee, Wareham, Nicholas, Key, Tim J, Romaguera, Dora, Lu, Yunxia, Lassale, Camille M, Naska, Androniki, Orfanos, Philippos, Trichopoulou, Antonia, Masala, Giovanna, Pala, Valeria, Berrino, Franco, Tumino, Rosario, Ricceri, Fulvio, de Magistris, Maria Santucci, Bueno-de-Mesquita, H Bas, Ocké, Marga C, Sonestedt, Emily, Ericson, Ulrika, Johansson, Mattias, Skeie, Guri, Weiderpass, Elisabete, Braaten, Tonje, Peeters, Petra HM, and Slimani, Nadia

Subjects
Public Health, Biomedical and Clinical Sciences, Nutrition and Dietetics, Health Sciences, Clinical Research, Prevention, Nutrition, Metabolic and endocrine, Adult, Aged, Ascorbic Acid, Calcium, Dietary, Diet, Dietary Fiber, Dietary Proteins, Europe, Female, Folic Acid, Follow-Up Studies, Humans, Linear Models, Male, Middle Aged, Nutrition Assessment, Phosphorus, Dietary, Prospective Studies, Riboflavin, Surveys and Questionnaires, Weight Gain, beta Carotene, Dietary patterns, Energy balance, Nutrients, Obesity, Public health, Weight gain, Nutrition & Dietetics, Nutrition and dietetics, Epidemiology
Abstract

PurposeVarious food patterns have been associated with weight change in adults, but it is unknown which combinations of nutrients may account for such observations. We investigated associations between main nutrient patterns and prospective weight change in adults.MethodsThis study includes 235,880 participants, 25-70 years old, recruited between 1992 and 2000 in 10 European countries. Intakes of 23 nutrients were estimated from country-specific validated dietary questionnaires using the harmonized EPIC Nutrient DataBase. Four nutrient patterns, explaining 67 % of the total variance of nutrient intakes, were previously identified from principal component analysis. Body weight was measured at recruitment and self-reported 5 years later. The relationship between nutrient patterns and annual weight change was examined separately for men and women using linear mixed models with random effect according to center controlling for confounders.ResultsMean weight gain was 460 g/year (SD 950) and 420 g/year (SD 940) for men and women, respectively. The annual differences in weight gain per one SD increase in the pattern scores were as follows: principal component (PC) 1, characterized by nutrients from plant food sources, was inversely associated with weight gain in men (-22 g/year; 95 % CI -33 to -10) and women (-18 g/year; 95 % CI -26 to -11). In contrast, PC4, characterized by protein, vitamin B2, phosphorus, and calcium, was associated with a weight gain of +41 g/year (95 % CI +2 to +80) and +88 g/year (95 % CI +36 to +140) in men and women, respectively. Associations with PC2, a pattern driven by many micro-nutrients, and with PC3, a pattern driven by vitamin D, were less consistent and/or non-significant.ConclusionsWe identified two main nutrient patterns that are associated with moderate but significant long-term differences in weight gain in adults.

Published
2016

12. The time-evolution of DCIS size distributions with applications to breast cancer growth and progression

Author

Dowty, James G., Byrnes, Graham B., and Gertig, Dorota M.

Subjects
Quantitative Biology - Populations and Evolution, Quantitative Biology - Quantitative Methods, Quantitative Biology - Tissues and Organs
Abstract

Ductal carcinoma {\em in situ} (DCIS) lesions are non-invasive tumours of the breast which are thought to precede most invasive breast cancers (IBC). As individual DCIS lesions are initiated, grow and invade (i.e. become IBC) the size distribution of the DCIS lesions present in a given human population will evolve. We derive a differential equation governing this evolution and show, for given assumptions about growth and invasion, that there is a unique distribution which does not vary with time. Further, we show that any initial distribution converges to this stationary distribution exponentially quickly. It is therefore reasonable to assume that the stationary distribution is equal to the true DCIS size distribution, at least for human populations which are relatively stable with respect to the determinants of breast cancer. Based on this assumption and the size data of 110 DCIS lesions detected in a mammographic screening program between 1993 and 2000, we produce maximum likelihood estimates for certain growth and invasion parameters. Assuming that DCIS size is proportional to a positive power $p$ of the time since tumour initiation we estimate $p$ to be 0.50 with a 95% confidence interval of $(0.35, 0.71)$. Therefore we estimate that DCIS lesions follow a square-root growth law and hence that they grow rapidly when small and relatively slowly when large. Our approach and results should be useful for other mathematical studies of cancer, especially those investigating biological mechanisms of invasion., Comment: 12 pages, 2 figures and 1 table. To appear in Mathematical Medicine and Biology

Published
2013
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13. Coffee and tea drinking in relation to the risk of differentiated thyroid carcinoma: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author

Zamora-Ros, Raul, Alghamdi, Muath A., Cayssials, Valerie, Franceschi, Silvia, Almquist, Martin, Hennings, Joakim, Sandström, Maria, Tsilidis, Konstantinos K., Weiderpass, Elisabete, Boutron-Ruault, Marie-Christine, Hammer Bech, Bodil, Overvad, Kim, Tjønneland, Anne, Petersen, Kristina E. N., Mancini, Francesca Romana, Mahamat-Saleh, Yahya, Bonnet, Fabrice, Kühn, Tilman, Fortner, Renée T., Boeing, Heiner, Trichopoulou, Antonia, Bamia, Christina, Martimianaki, Georgia, Masala, Giovanna, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Fasanelli, Francesca, Skeie, Guri, Braaten, Tonje, Lasheras, Cristina, Salamanca-Fernández, Elena, Amiano, Pilar, Chirlaque, Maria-Dolores, Barricarte, Aurelio, Manjer, Jonas, Wallström, Peter, Bueno-de-Mesquita, H. Bas, Peeters, Petra H., Khaw, Kay-Thee, Wareham, Nicholas J., Schmidt, Julie A., Aune, Dagfinn, Byrnes, Graham, Scalbert, Augustin, Agudo, Antonio, and Rinaldi, Sabina

Published
2019
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14. Urinary TERT promoter mutations as non-invasive biomarkers for the comprehensive detection of urothelial cancer

Author

Avogbe, Patrice Hodonou, Manel, Arnaud, Vian, Emmanuel, Durand, Geoffroy, Forey, Nathalie, Voegele, Catherine, Zvereva, Maria, Hosen, Md Ismail, Meziani, Sonia, De Tilly, Berengere, Polo, Gilles, Lole, Olesia, Francois, Pauline, Delhomme, Tiffany Myriam, Carreira, Christine, Monteiro-Reis, Sara, Henrique, Rui, Abedi-Ardekani, Behnoush, Byrnes, Graham, Foll, Matthieu, Weiderpass, Elisabete, McKay, James, Jeronimo, Carmen, Scelo, Ghislaine, and Le Calvez-Kelm, Florence

Published
2019
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17. Perspective: An Extension of the STROBE Statement for Observational Studies in Nutritional Epidemiology (STROBE-nut): Explanation and Elaboration

Author

Hörnell, Agneta, Berg, Christina, Forsum, Elisabet, Larsson, Christel, Sonestedt, Emily, Åkesson, Agneta, Lachat, Carl, Hawwash, Dana, Kolsteren, Patrick, Byrnes, Graham, De Keyzer, Willem, Van Camp, John, Cade, Janet E, Greenwood, Darren C, Slimani, Nadia, Cevallos, Myriam, Egger, Matthias, Huybrechts, Inge, and Wirfält, Elisabet

Published
2017
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18. DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility

Author

Ambatipudi, Srikant, Horvath, Steve, Perrier, Flavie, Cuenin, Cyrille, Hernandez-Vargas, Hector, Le Calvez-Kelm, Florence, Durand, Geoffroy, Byrnes, Graham, Ferrari, Pietro, Bouaoun, Liacine, Sklias, Athena, Chajes, Véronique, Overvad, Kim, Severi, Gianluca, Baglietto, Laura, Clavel-Chapelon, Françoise, Kaaks, Rudolf, Barrdahl, Myrto, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Naska, Androniki, Masala, Giovanna, Agnoli, Claudia, Polidoro, Silvia, Tumino, Rosario, Panico, Salvatore, Dollé, Martijn, Peeters, Petra H.M., Onland-Moret, N. Charlotte, Sandanger, Torkjel M., Nøst, Therese H., Weiderpass, Elisabete, Quirós, J. Ramón, Agudo, Antonio, Rodriguez-Barranco, Miguel, Huerta Castaño, José María, Barricarte, Aurelio, Fernández, Ander Matheu, Travis, Ruth C., Vineis, Paolo, Muller, David C., Riboli, Elio, Gunter, Marc, Romieu, Isabelle, and Herceg, Zdenko

Published
2017
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19. BAP1 Is Altered by Copy Number Loss, Mutation, and/or Loss of Protein Expression in More Than 70% of Malignant Peritoneal Mesotheliomas

Author

Leblay, Noémie, Leprêtre, Frédéric, Le Stang, Nolwenn, Gautier-Stein, Amandine, Villeneuve, Laurent, Isaac, Sylvie, Maillet, Denis, Galateau-Sallé, Françoise, Villenet, Céline, Sebda, Shéhérazade, Goracci, Alexandra, Byrnes, Graham, McKay, James D, Figeac, Martin, Glehen, Olivier, Gilly, François-Noël, Foll, Matthieu, Fernandez-Cuesta, Lynnette, and Brevet, Marie

Published
2017
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21. Supplementary Tables 1-2 from Genetic Polymorphisms in 15q25 and 19q13 Loci, Cotinine Levels, and Risk of Lung Cancer in EPIC

Author

Timofeeva, Maria N., primary, McKay, James D., primary, Davey, Smith George, primary, Johansson, Mattias, primary, Byrnes, Graham B., primary, Chabrier, Amélie, primary, Relton, Caroline, primary, Ueland, Per Magne, primary, Vollset, Stein Emil, primary, Midttun, Øivind, primary, Nygård, Ottar, primary, Slimani, Nadia, primary, Romieu, Isabelle, primary, Clavel-Chapelon, Françoise, primary, Boutron-Ruault, Marie-Christine, primary, Fagherazzi, Guy, primary, Kaaks, Rudolf, primary, Teucher, Birgit, primary, Boeing, Heiner, primary, Weikert, Cornelia, primary, Bueno-de-Mesquita, H. Bas, primary, van Gils, Carla, primary, Peeters, Petra H.M., primary, Agudo, Antonio, primary, Barricarte, Aurelio, primary, Huerta, Jose-Maria, primary, Rodríguez, Laudina, primary, Sánchez, Maria-José, primary, Larrañaga, Nerea, primary, Khaw, Kay-Tee, primary, Wareham, Nick, primary, Allen, Naomi E., primary, Travis, Ruth C., primary, Gallo, Valentina, primary, Norat, Teresa, primary, Krogh, Vittorio, primary, Masala, Giovanna, primary, Panico, Salvatore, primary, Sacerdote, Carlotta, primary, Tumino, Rosario, primary, Trichopoulou, Antonia, primary, Lagiou, Pagona, primary, Trichopoulos, Dimitrios, primary, Rasmuson, Torgny, primary, Hallmans, Göran, primary, Riboli, Elio, primary, Vineis, Paolo, primary, and Brennan, Paul, primary

Published
2023
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22. Supplementary Tables 1-3 from A Sex-Specific Association between a 15q25 Variant and Upper Aerodigestive Tract Cancers

Author

Chen, Dan, primary, Truong, Therese, primary, Gaborieau, Valerie, primary, Byrnes, Graham, primary, Chabrier, Amelie, primary, Chuang, Shu-chun, primary, Olshan, Andrew F., primary, Weissler, Mark C., primary, Luo, Jingchun, primary, Romkes, Marjorie, primary, Buch, Shama, primary, Nukui, Tomoko, primary, Franceschi, Silvia, primary, Herrero, Rolando, primary, Talamini, Renato, primary, Kelsey, Karl T., primary, Christensen, Brock, primary, McClean, Michael D., primary, Lacko, Martin, primary, Manni, Johannes J., primary, Peters, Wilbert H. M., primary, Lubiński, Jan, primary, Trubicka, Joanna, primary, Lener, Marcin, primary, Muscat, Joshua E., primary, Lazarus, Philip, primary, Wei, Qingyi, primary, Sturgis, Erich M., primary, Zhang, Zuo-Feng, primary, Chang, Shen-Chih, primary, Wang, Renyi, primary, Schwartz, Stephen M., primary, Chen, Chu, primary, Benhamou, Simone, primary, Lagiou, Pagona, primary, Holcátová, Ivana, primary, Richiardi, Lorenzo, primary, Kjaerheim, Kristina, primary, Agudo, Antonio, primary, Castellsagué, Xavier, primary, Macfarlane, Tatiana V., primary, Barzan, Luigi, primary, Canova, Cristina, primary, Thakker, Nalin S., primary, Conway, David I., primary, Znaor, Ariana, primary, Healy, Claire M., primary, Ahrens, Wolfgang, primary, Zaridze, David, primary, Szeszenia-Dabrowska, Neonila, primary, Lissowska, Jolanta, primary, Fabianova, Eleonora, primary, Bucur, Alexandru, primary, Bencko, Vladimir, primary, Foretova, Lenka, primary, Janout, Vladimir, primary, Curado, Maria Paula, primary, Koifman, Sergio, primary, Menezes, Ana, primary, Wünsch-Filho, Victor, primary, Eluf-Neto, José, primary, Fernandez, Leticia, primary, Boccia, Stefania, primary, Hashibe, Mia, primary, Hayes, Richard B., primary, Boffetta, Paolo, primary, Brennan, Paul, primary, and McKay, James D., primary

Published
2023
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23. Data from A Sex-Specific Association between a 15q25 Variant and Upper Aerodigestive Tract Cancers

Author

Chen, Dan, primary, Truong, Therese, primary, Gaborieau, Valerie, primary, Byrnes, Graham, primary, Chabrier, Amelie, primary, Chuang, Shu-chun, primary, Olshan, Andrew F., primary, Weissler, Mark C., primary, Luo, Jingchun, primary, Romkes, Marjorie, primary, Buch, Shama, primary, Nukui, Tomoko, primary, Franceschi, Silvia, primary, Herrero, Rolando, primary, Talamini, Renato, primary, Kelsey, Karl T., primary, Christensen, Brock, primary, McClean, Michael D., primary, Lacko, Martin, primary, Manni, Johannes J., primary, Peters, Wilbert H. M., primary, Lubiński, Jan, primary, Trubicka, Joanna, primary, Lener, Marcin, primary, Muscat, Joshua E., primary, Lazarus, Philip, primary, Wei, Qingyi, primary, Sturgis, Erich M., primary, Zhang, Zuo-Feng, primary, Chang, Shen-Chih, primary, Wang, Renyi, primary, Schwartz, Stephen M., primary, Chen, Chu, primary, Benhamou, Simone, primary, Lagiou, Pagona, primary, Holcátová, Ivana, primary, Richiardi, Lorenzo, primary, Kjaerheim, Kristina, primary, Agudo, Antonio, primary, Castellsagué, Xavier, primary, Macfarlane, Tatiana V., primary, Barzan, Luigi, primary, Canova, Cristina, primary, Thakker, Nalin S., primary, Conway, David I., primary, Znaor, Ariana, primary, Healy, Claire M., primary, Ahrens, Wolfgang, primary, Zaridze, David, primary, Szeszenia-Dabrowska, Neonila, primary, Lissowska, Jolanta, primary, Fabianova, Eleonora, primary, Bucur, Alexandru, primary, Bencko, Vladimir, primary, Foretova, Lenka, primary, Janout, Vladimir, primary, Curado, Maria Paula, primary, Koifman, Sergio, primary, Menezes, Ana, primary, Wünsch-Filho, Victor, primary, Eluf-Neto, José, primary, Fernandez, Leticia, primary, Boccia, Stefania, primary, Hashibe, Mia, primary, Hayes, Richard B., primary, Boffetta, Paolo, primary, Brennan, Paul, primary, and McKay, James D., primary

Published
2023
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24. Data from Genetic Polymorphisms in 15q25 and 19q13 Loci, Cotinine Levels, and Risk of Lung Cancer in EPIC

Author

Timofeeva, Maria N., primary, McKay, James D., primary, Davey, Smith George, primary, Johansson, Mattias, primary, Byrnes, Graham B., primary, Chabrier, Amélie, primary, Relton, Caroline, primary, Ueland, Per Magne, primary, Vollset, Stein Emil, primary, Midttun, Øivind, primary, Nygård, Ottar, primary, Slimani, Nadia, primary, Romieu, Isabelle, primary, Clavel-Chapelon, Françoise, primary, Boutron-Ruault, Marie-Christine, primary, Fagherazzi, Guy, primary, Kaaks, Rudolf, primary, Teucher, Birgit, primary, Boeing, Heiner, primary, Weikert, Cornelia, primary, Bueno-de-Mesquita, H. Bas, primary, van Gils, Carla, primary, Peeters, Petra H.M., primary, Agudo, Antonio, primary, Barricarte, Aurelio, primary, Huerta, Jose-Maria, primary, Rodríguez, Laudina, primary, Sánchez, Maria-José, primary, Larrañaga, Nerea, primary, Khaw, Kay-Tee, primary, Wareham, Nick, primary, Allen, Naomi E., primary, Travis, Ruth C., primary, Gallo, Valentina, primary, Norat, Teresa, primary, Krogh, Vittorio, primary, Masala, Giovanna, primary, Panico, Salvatore, primary, Sacerdote, Carlotta, primary, Tumino, Rosario, primary, Trichopoulou, Antonia, primary, Lagiou, Pagona, primary, Trichopoulos, Dimitrios, primary, Rasmuson, Torgny, primary, Hallmans, Göran, primary, Riboli, Elio, primary, Vineis, Paolo, primary, and Brennan, Paul, primary

Published
2023
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25. Supplementary Methods from Genetic Polymorphisms in 15q25 and 19q13 Loci, Cotinine Levels, and Risk of Lung Cancer in EPIC

Author

Timofeeva, Maria N., primary, McKay, James D., primary, Davey, Smith George, primary, Johansson, Mattias, primary, Byrnes, Graham B., primary, Chabrier, Amélie, primary, Relton, Caroline, primary, Ueland, Per Magne, primary, Vollset, Stein Emil, primary, Midttun, Øivind, primary, Nygård, Ottar, primary, Slimani, Nadia, primary, Romieu, Isabelle, primary, Clavel-Chapelon, Françoise, primary, Boutron-Ruault, Marie-Christine, primary, Fagherazzi, Guy, primary, Kaaks, Rudolf, primary, Teucher, Birgit, primary, Boeing, Heiner, primary, Weikert, Cornelia, primary, Bueno-de-Mesquita, H. Bas, primary, van Gils, Carla, primary, Peeters, Petra H.M., primary, Agudo, Antonio, primary, Barricarte, Aurelio, primary, Huerta, Jose-Maria, primary, Rodríguez, Laudina, primary, Sánchez, Maria-José, primary, Larrañaga, Nerea, primary, Khaw, Kay-Tee, primary, Wareham, Nick, primary, Allen, Naomi E., primary, Travis, Ruth C., primary, Gallo, Valentina, primary, Norat, Teresa, primary, Krogh, Vittorio, primary, Masala, Giovanna, primary, Panico, Salvatore, primary, Sacerdote, Carlotta, primary, Tumino, Rosario, primary, Trichopoulou, Antonia, primary, Lagiou, Pagona, primary, Trichopoulos, Dimitrios, primary, Rasmuson, Torgny, primary, Hallmans, Göran, primary, Riboli, Elio, primary, Vineis, Paolo, primary, and Brennan, Paul, primary

Published
2023
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26. Sweetened beverages are associated with a higher risk of differentiated thyroid cancer in the EPIC cohort:a dietary pattern approach

Author

Zamora-Ros, Raul, Cayssials, Valerie, Cleries, Ramon, Torrents, Maria, Byrnes, Graham, Weiderpass, Elisabete, Sandstrom, Maria, Almquist, Martin, Boutron-Ruault, Marie-Christine, Tjonneland, Anne, Kyro, Cecilie, Katzke, Verena A., Le Cornet, Charlotte, Masala, Giovanna, Krogh, Vittorio, Iannuzzo, Gabriella, Tumino, Rosario, Milani, Lorenzo, Skeie, Guri, Ubago-Guisado, Esther, Amiano, Pilar, Chirlaque, Maria-Dolores, Ardanaz, Eva, Janzi, Suzanne, Eriksson, Linda, Freisling, Heinz, Heath, Alicia K., Rinaldi, Sabina, Agudo, Antonio, Zamora-Ros, Raul, Cayssials, Valerie, Cleries, Ramon, Torrents, Maria, Byrnes, Graham, Weiderpass, Elisabete, Sandstrom, Maria, Almquist, Martin, Boutron-Ruault, Marie-Christine, Tjonneland, Anne, Kyro, Cecilie, Katzke, Verena A., Le Cornet, Charlotte, Masala, Giovanna, Krogh, Vittorio, Iannuzzo, Gabriella, Tumino, Rosario, Milani, Lorenzo, Skeie, Guri, Ubago-Guisado, Esther, Amiano, Pilar, Chirlaque, Maria-Dolores, Ardanaz, Eva, Janzi, Suzanne, Eriksson, Linda, Freisling, Heinz, Heath, Alicia K., Rinaldi, Sabina, and Agudo, Antonio

Abstract

Background Dietary pattern analysis has gained particular interest, because it reflects the complexity of dietary intake. The aim of this study was to explore the associations between a posteriori dietary patterns, derived using a data-driven approach, and the risk of differentiated thyroid cancer (TC) in Europe. Methods This investigation included 450,064 adults from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Dietary intake was assessed using validated country-specific dietary questionnaires. A posteriori dietary patterns were computed using principal component analyses. Cox regression was used to calculate multivariable adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). Results After a mean follow-up time of 14 years, 712 first differentiated TCs were diagnosed. In the fully adjusted model, a dietary pattern characterized by alcohol consumption (basically beer and wine) was negatively associated with differentiated TC risk (HRQ4vs.Q1 = 0.75; 95% CI:0.60-0.94, P-trend = 0.005), while a dietary pattern rich in sweetened beverages was positively associated with differentiated TC risk (HRQ4vs.Q1 = 1.26; 95% CI:0.99-1.61; P-trend = 0.07). The remaining 8 dietary patterns were not related to differentiated TC risk. The intake of sweetened beverages was positively associated with differentiated TC risk (HR100mL/d = 1.05; 95% CI:1.00-1.11), especially with papillary TC risk (HR100mL/d = 1.07; 95% CI:1.01-1.13). Similar results were observed with sugary and artificially sweetened beverages. Conclusions The investigation of dietary patterns detected that the consumption of sweetened beverages was associated with a higher risk of differentiated thyroid cancer. Our results are in line with the general dietary recommendations of reducing the consumption of sweetened beverages.

Published
2023

29. Sweetened beverages are associated with a higher risk of differentiated thyroid cancer in the EPIC cohort: a dietary pattern approach

Author

Zamora-Ros, Raul, primary, Cayssials, Valerie, additional, Clèries, Ramon, additional, Torrents, Maria, additional, Byrnes, Graham, additional, Weiderpass, Elisabete, additional, Sandström, Maria, additional, Almquist, Martin, additional, Boutron-Ruault, Marie-Christine, additional, Tjønneland, Anne, additional, Kyrø, Cecilie, additional, Katzke, Verena A., additional, Le Cornet, Charlotte, additional, Masala, Giovanna, additional, Krogh, Vittorio, additional, Iannuzzo, Gabriella, additional, Tumino, Rosario, additional, Milani, Lorenzo, additional, Skeie, Guri, additional, Ubago-Guisado, Esther, additional, Amiano, Pilar, additional, Chirlaque, María-Dolores, additional, Ardanaz, Eva, additional, Janzi, Suzanne, additional, Eriksson, Linda, additional, Freisling, Heinz, additional, Heath, Alicia K., additional, Rinaldi, Sabina, additional, and Agudo, Antonio, additional

Published
2022
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31. Risk of Thyroid Cancer among Chernobyl Liquidators

Author

Kesminiene, Ausrele, Evrard, Anne-Sophie, Ivanov, Viktor K., Malakhova, Irina V., Kurtinaitise, Juozas, Stengrevics, Aivars, Tekkel, Mare, Chekin, Sergei, Drozdovitch, Vladimir, Gavrilin, Yuri, Golovanov, Ivan, Kryuchkov, Viktor P., Maceika, Evaldas, Mirkhaidarov, Anatoly K., Polyakov, Semion, Tenet, Vanessa, Tukov, Aleksandr R., Byrnes, Graham, and Cardis, Elisabeth

Published
2012
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32. Sweetened beverages are associated with a higher risk of differentiated thyroid cancer in the EPIC cohort : a dietary pattern approach

Author

Zamora-Ros, Raul, Cayssials, Valerie, Clèries, Ramon, Torrents, Maria, Byrnes, Graham, Weiderpass, Elisabete, Sandström, Maria, Almquist, Martin, Boutron-Ruault, Marie-Christine, Tjønneland, Anne, Kyrø, Cecilie, Katzke, Verena A., Le Cornet, Charlotte, Masala, Giovanna, Krogh, Vittorio, Iannuzzo, Gabriella, Tumino, Rosario, Milani, Lorenzo, Skeie, Guri, Ubago-Guisado, Esther, Amiano, Pilar, Chirlaque, María-Dolores, Ardanaz, Eva, Janzi, Suzanne, Eriksson, Linda, Freisling, Heinz, Heath, Alicia K., Rinaldi, Sabina, Agudo, Antonio, Zamora-Ros, Raul, Cayssials, Valerie, Clèries, Ramon, Torrents, Maria, Byrnes, Graham, Weiderpass, Elisabete, Sandström, Maria, Almquist, Martin, Boutron-Ruault, Marie-Christine, Tjønneland, Anne, Kyrø, Cecilie, Katzke, Verena A., Le Cornet, Charlotte, Masala, Giovanna, Krogh, Vittorio, Iannuzzo, Gabriella, Tumino, Rosario, Milani, Lorenzo, Skeie, Guri, Ubago-Guisado, Esther, Amiano, Pilar, Chirlaque, María-Dolores, Ardanaz, Eva, Janzi, Suzanne, Eriksson, Linda, Freisling, Heinz, Heath, Alicia K., Rinaldi, Sabina, and Agudo, Antonio

Abstract

Background: Dietary pattern analysis has gained particular interest, because it reflects the complexity of dietary intake. The aim of this study was to explore the associations between a posteriori dietary patterns, derived using a data-driven approach, and the risk of differentiated thyroid cancer (TC) in Europe. Methods: This investigation included 450,064 adults from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Dietary intake was assessed using validated country-specific dietary questionnaires. A posteriori dietary patterns were computed using principal component analyses. Cox regression was used to calculate multivariable adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). Results: After a mean follow-up time of 14 years, 712 first differentiated TCs were diagnosed. In the fully adjusted model, a dietary pattern characterized by alcohol consumption (basically beer and wine) was negatively associated with differentiated TC risk (HRQ4vs.Q1 = 0.75; 95% CI:0.60–0.94, P-trend = 0.005), while a dietary pattern rich in sweetened beverages was positively associated with differentiated TC risk (HRQ4vs.Q1 = 1.26; 95% CI:0.99–1.61; P-trend = 0.07). The remaining 8 dietary patterns were not related to differentiated TC risk. The intake of sweetened beverages was positively associated with differentiated TC risk (HR100mL/d = 1.05; 95% CI:1.00–1.11), especially with papillary TC risk (HR100mL/d = 1.07; 95% CI:1.01–1.13). Similar results were observed with sugary and artificially sweetened beverages. Conclusions: The investigation of dietary patterns detected that the consumption of sweetened beverages was associated with a higher risk of differentiated thyroid cancer. Our results are in line with the general dietary recommendations of reducing the consumption of sweetened beverages.

Published
2022
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34. A Rare Truncating BRCA2 Variant and Genetic Susceptibility to Upper Aerodigestive Tract Cancer

Author

Delahaye-Sourdeix, Manon, Anantharaman, Devasena, Timofeeva, Maria N., Gaborieau, Valérie, Chabrier, Amélie, Vallée, Maxime P., Lagiou, Pagona, Holcátová, Ivana, Richiardi, Lorenzo, Kjaerheim, Kristina, Agudo, Antonio, Castellsagué, Xavier, Macfarlane, Tatiana V., Barzan, Luigi, Canova, Cristina, Thakker, Nalin S., Conway, David I., Znaor, Ariana, Healy, Claire M., Ahrens, Wolfgang, Zaridze, David, Szeszenia-Dabrowska, Neonilia, Lissowska, Jolanta, Fabianova, Eleonora, Mates, Ioan Nicolae, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Curado, Maria Paula, Koifman, Sergio, Menezes, Ana, Wünsch-Filho, Victor, Eluf-Neto, José, Boffetta, Paolo, Fernández Garrote, Leticia, Polesel, Jerry, Lener, Marcin, Jaworowska, Ewa, Lubiński, Jan, Boccia, Stefania, Rajkumar, Thangarajan, Samant, Tanuja A., Mahimkar, Manoj B., Matsuo, Keitaro, Franceschi, Silvia, Byrnes, Graham, Brennan, Paul, and McKay, James D.

Published
2015
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35. Energy and macronutrient intake and risk of differentiated thyroid carcinoma in the European Prospective Investigation into Cancer and Nutrition study

Author

Zamora-Ros, Raul, Rinaldi, Sabina, Tsilidis, Konstantinos K., Weiderpass, Elisabete, Boutron-Ruault, Marie-Christine, Rostgaard-Hansen, Agnetha Linn, Tjnneland, Anne, Clavel-Chapelon, Françoise, Mesrine, Sylvie, Katzke, Verena A., Kühn, Tilman, Förster, Jana, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Klinaki, Eleni, Masala, Giovanna, Sieri, Sabina, Ricceri, Fulvio, Tumino, Rosario, Mattiello, Amalia, Peeters, Petra H.M., Bueno-de-Mesquita, H. B(as), Engeset, Dagrun, Skeie, Guri, Argüelles, Marcial, Agudo, Antonio, Sánchez, María-José, Chirlaque, María-Dolores, Barricarte, Aurelio, Chamosa, Saioa, Almquist, Martin, Tosovic, Ada, Hennings, Joakim, Sandström, Maria, Schmidt, Julie A, Khaw, Kay-Thee, Wareham, Nicholas J., Cross, Amanda J., Slimani, Nadia, Byrnes, Graham, Romieu, Isabelle, Riboli, Elio, and Franceschi, Silvia

Published
2016
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36. A statistical framework to model the meeting-in-the-middle principle using metabolomic data: application to hepatocellular carcinoma in the EPIC study

Author

Assi, Nada, Fages, Anne, Vineis, Paolo, Chadeau-Hyam, Marc, Stepien, Magdalena, Duarte-Salles, Talita, Byrnes, Graham, Boumaza, Houda, Knüppel, Sven, Kühn, Tilman, Palli, Domenico, Bamia, Christina, Boshuizen, Hendriek, Bonet, Catalina, Overvad, Kim, Johansson, Mattias, Travis, Ruth, Gunter, Marc J., Lund, Eiliv, Dossus, Laure, Elena-Herrmann, Bénédicte, Riboli, Elio, Jenab, Mazda, Viallon, Vivian, and Ferrari, Pietro

Published
2015
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38. O-217 Asbest Chrysotile Cohort Study profile, exposure distribution and outcomes

Author

Olsson, Ann, primary, Schuz, Joachim, additional, Straif, Kurt, additional, Kromhout, Hans, additional, Moissonnier, Monika, additional, Ostroumova, Evgenia, additional, Byrnes, Graham, additional, Ferro, Gilles, additional, Feletto, Eleonora, additional, Schonfeld, Sara J, additional, Bukhtiyarov, Igor, additional, Tskhomariia, Iraklii, additional, Kashanskiy, Sergey, additional, Morozova, Tatiana, additional, and Kovalevskiy, Evgeny, additional

Published
2021
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39. Maternal Age And Risk Of Type 1 Diabetes In Children

Author

Byrnes, Graham, Patterson, C. C., Dahlquist, G., Soltész, G., Gunn, Alistair J., Cutfield, Wayne S., Hofman, Paul L., Jeferries, Craig, Stene, Lars Christian, Joner, Geir, Bingley, Polly J., and Gale, Edwin A. M.

Published
2001

40. Dried venous blood samples for the detection and quantification of measles IgG using a commercial enzyme immunoassay

Author

Riddell Michaela A., Byrnes Graham B., Leydon Jennie A., and Kelly Heath A.

Subjects
Measles/immunology, Measles/diagnosis, Blood specimen collection/methods, Immunoenzyme techniques, Immunoglobulin G, Sensitivity and specificity, Seroepidemiologic studies, Public aspects of medicine, RA1-1270
Abstract

OBJECTIVES: To determine whether samples of dried venous blood (DVB) were an acceptable alternative to serum for detecting measles-specific IgG in a commercial enzyme immunoassay. METHODS: Paired samples of serum and DVB were collected from 98 suspected cases of measles and 1153 schoolchildren in Victoria, Australia. All samples were tested using the Dade Behring Enzygnost® Anti-Measles-Virus/IgG immunoassay. DVB samples were eluted using either the sample buffer provided with the kit or 5% dry milk powder in phosphate-buffered saline-Tween 20. FINDINGS: DVB samples eluted by sample buffer showed significantly better linear correlation to the serum samples than did DVB samples eluted in 5% dry milk in phosphate-buffered saline-Tween 20. To improve the comparability of serum and DVB samples an adjustment factor of 1.28 was applied to the optical density (OD) values of DVB. This adjustment also enabled quantification of the titre of measles IgG in mIU/ml directly from the OD value using the alpha calculation as specified by the kit protocol. For DVB samples stored for less than six months at 4 °C, the assay showed an overall sensitivity of 98.4% and a specificity of 97.2% compared with the results of serum testing. CONCLUSION: These results illustrate the potential for DVB samples to be widely used with the Dade Behring enzyme immunoassay system for determining the immunity of the individual and the population to the measles virus.

Published
2003

41. Meat, eggs, dairy products, and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

Pala, Valeria, Krogh, Vittorio, Berrino, Franco, Sieri, Sabina, Grioni, Sara, Tjønneland, Anne, Olsen, Anja, Jakobsen, Marianne Uhre, Overvad, Kim, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Romieu, Isabelle, Linseisen, Jakob, Rohrmann, Sabine, Boeing, Heiner, Steffen, Annika, Trichopoulou, Antonia, Benetou, Vassiliki, Naska, Androniki, Vineis, Paolo, Tumino, Rosario, Panico, Salvatore, Masala, Giovanna, Agnoli, Claudia, Engeset, Dagrun, Skeie, Guri, Lund, Eiliv, Ardanaz, Eva, Navarro, Carmen, Sánchez, Maria-José, Amiano, Pilar, Svatetz, Carlos Alberto Gonzalez, Rodriguez, Laudina, Wirfält, Elisabet, Manjer, Jonas, Lenner, Per, Hallmans, Göran, Peeters, Petra HM, van Gils, Carla H, Bueno-de-Mesquita, H Bas, van Duijnhoven, Fränzel JB, Key, Timothy J, Spencer, Elizabeth, Bingham, Sheila, Khaw, Kay-Tee, Ferrari, Pietro, Byrnes, Graham, Rinaldi, Sabina, Norat, Teresa, Michaud, Dominique S, and Riboli, Elio

Published
2009
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42. Reproductive and menstrual factors and risk of differentiated thyroid carcinoma: The EPIC study

Author

Zamora-Ros, Raul, Rinaldi, Sabina, Biessy, Carine, Tjnneland, Anne, Halkjær, Jytte, Fournier, Agnes, Boutron-Ruault, Marie-Christine, Mesrine, Sylvie, Tikk, Kaja, Fortner, Reneé T., Boeing, Heiner, Förster, Jana, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Papatesta, Eleni-Maria, Masala, Giovanna, Tagliabue, Giovanna, Panico, Salvatore, Tumino, Rosario, Polidoro, Silvia, Peeters, Petra H.M., Bueno-de-Mesquita, H. B(as), Weiderpass, Elisabete, Lund, Eiliv, Argüelles, Marcial, Agudo, Antonio, Molina-Montes, Esther, Navarro, Carmen, Barricarte, Aurelio, Larrañaga, Nerea, Manjer, Jonas, Almquist, Martin, Sandström, Maria, Hennings, Joakim, Tsilidis, Konstantinos K., Schmidt, Julie A., Khaw, Kay-Thee, Wareham, Nicholas J., Romieu, Isabelle, Byrnes, Graham, Gunter, Marc J., Riboli, Elio, and Franceschi, Silvia

Published
2015
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43. Plasma phospholipid fatty acid profiles and their association with food intakes: results from a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition

Author

Saadatian-Elahi, Mitra, Slimani, Nadia, Chajès, Véronique, Jenab, Mazda, Goudable, Joëlle, Biessy, Carine, Ferrari, Pietro, Byrnes, Graham, Autier, Philippe, Peeters, Petra HM, Ocké, Marga, Bueno de Mesquita, Bas, Johansson, Ingegerd, Hallmans, Göran, Manjer, Jonas, Wirfält, Elisabet, González, Carlos A, Navarro, Carmen, Martinez, Carmen, Amiano, Pilar, Suárez, Laudina Rodriguez, Ardanaz, Eva, Tjønneland, Anne, Halkjaer, Jytte, Overvad, Kim, Jakobsen, Marianne Uhre, Berrino, Franco, Pala, Valeria, Palli, Domenico, Tumino, Rosario, Vineis, Paolo, Santucci de Magistris, Maria, Spencer, Elisabeth A, Crowe, Francesca L, Bingham, Sheila, Khaw, Kay-Tee, Linseisen, Jakob, Rohrmann, Sabine, Boeing, Heiner, Noethlings, Ute, Olsen, Karina Standahl, Skeie, Guri, Lund, Eiliv, Trichopoulou, Antonia, Oustoglou, Erifili, Clavel-Chapelon, Françoise, and Riboli, Elio

Published
2009
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44. Blood polyphenol concentrations and differentiated thyroid carcinoma in women from the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author

Zamora-Ros, Raul, Lujan-Barroso, Leila, Achaintre, David, Franceschi, Silvia, Kyro, Cecilie, Overvad, Kim, Tjonneland, Anne, Truong, Therese, Lecuyer, Lucie, Boutron-Ruault, Marie-Christine, Katzke, Verena, Johnson, Theron S., Schulze, Matthias B., Trichopoulou, Antonia, Peppa, Eleni, La Vechia, Carlo, Masala, Giovanna, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, Skeie, Guri, Quiros, J. Ramon, Rodriguez-Barranco, Miguel, Amiano, Pilar, Chirlaque, Maria-Dolores, Ardanaz, Eva, Almquist, Martin, Hennings, Joakim, Vermeulen, Roel, Wareham, Nicholas J., Tong, Tammy Y. N., Aune, Dagfinn, Byrnes, Graham, Weiderpass, Elisabete, Scalbert, Augustin, Rinaldi, Sabina, Agudo, Antonio, Zamora-Ros, Raul, Lujan-Barroso, Leila, Achaintre, David, Franceschi, Silvia, Kyro, Cecilie, Overvad, Kim, Tjonneland, Anne, Truong, Therese, Lecuyer, Lucie, Boutron-Ruault, Marie-Christine, Katzke, Verena, Johnson, Theron S., Schulze, Matthias B., Trichopoulou, Antonia, Peppa, Eleni, La Vechia, Carlo, Masala, Giovanna, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, Skeie, Guri, Quiros, J. Ramon, Rodriguez-Barranco, Miguel, Amiano, Pilar, Chirlaque, Maria-Dolores, Ardanaz, Eva, Almquist, Martin, Hennings, Joakim, Vermeulen, Roel, Wareham, Nicholas J., Tong, Tammy Y. N., Aune, Dagfinn, Byrnes, Graham, Weiderpass, Elisabete, Scalbert, Augustin, Rinaldi, Sabina, and Agudo, Antonio

Abstract

Background: Polyphenols are natural compounds with anticarcinogenic properties in cellular and animal models, but epidemiological evidence determining the associations of these compounds with thyroid cancer (TC) is lacking. Objectives: The aim of this study was to evaluate the relations between blood concentrations of 36 polyphenols and TC risk in EPIC (the European Prospective Investigation into Cancer and Nutrition). Methods: A nested case-control study was conducted on 273 female cases (210 papillary, 45 follicular, and 18 not otherwise specified TC tumors) and 512 strictly matched controls. Blood polyphenol concentrations were analyzed by HPLC coupled to tandem MS after enzymatic hydrolysis. Results: Using multivariable-adjusted conditional logistic regression models, caffeic acid (ORlog2: 0.55; 95% CI: 0.33, 0.93) and its dehydrogenated metabolite, 3,4-dihydroxyphenylpropionic acid (ORlog2: 0.84; 95% CI: 0.71, 0.99), were inversely associated with differentiated TC risk. Similar results were observed for papillary TC, but not for follicular TC. Ferulic acid was also inversely associated only with papillary TC (ORlog2: 0.68; 95% CI: 0.51, 0.91). However, none of these relations was significant after Bonferroni correction for multiple testing. No association was observed for any of the remaining polyphenols with total differentiated, papillary, or follicular TC. Conclusions: Blood polyphenol concentrations were mostly not associated with differentiated TC risk in women, although our study raises the possibility that high blood concentrations of caffeic, 3,4-dihydroxyphenylpropionic, and ferulic acids may be related to a lower papillary TC risk.

Published
2021
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45. Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial

Author

Davis, Stephen M, Donnan, Geoffrey A, Parsons, Mark W, Levi, Christopher, Butcher, Kenneth S, Peeters, Andre, Barber, P Alan, Bladin, Christopher, De Silva, Deidre A, Byrnes, Graham, Chalk, Jonathan B, Fink, John N, Kimber, Thomas E, Schultz, David, Hand, Peter J, Frayne, Judith, Hankey, Graeme, Muir, Keith, Gerraty, Richard, Tress, Brian M, and Desmond, Patricia M

Published
2008
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46. Thyroid-Stimulating Hormone, Thyroglobulin, and Thyroid Hormones and Risk of Differentiated Thyroid Carcinoma: The EPIC Study

Author

Rinaldi, Sabina, Plummer, Martyn, Biessy, Carine, Tsilidis, Konstantinos K., Østergaard, Jane Nautrup, Overvad, Kim, Tjønneland, Anne, Halkjær, Jytte, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Françoise, Dossus, Laure, Kaaks, Rudolf, Lukanova, Annekatrin, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, Bueno-de-Mesquita, Bas H., Peeters, Petra H, Weiderpass, Elisabete, Lund, Eiliv, Quirós, Ramón J., Agudo, Antonio, Molina, Esther, Larrañaga, Nerea, Navarro, Carmen, Ardanaz, Eva, Manjer, Jonas, Almquist, Martin, Sandström, Maria, Hennings, Joakim, Khaw, Kay-Tee, Schmidt, Julie, Travis, Ruth C., Byrnes, Graham, Scalbert, Augustin, Romieu, Isabelle, Gunter, Marc, Riboli, Elio, and Franceschi, Silvia

Published
2014
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48. Rare, evolutionarily unlikely missense substitutions in ATM Confer increased risk of breast cancer

Author

Tavtigian, Sean V., Oefner, Peter J., Babikyan, Davit, Hartmann, Anne, Chenevix-Trench, Georgia, John, Esther M., Healey, Sue, Le Calvez-Kelm, Florence, Lesueur, Fabienne, Andrulis, Irene L., Southey, Melissa C., Byrnes, Graham B., Shu-Chun Chuang, Forey, Nathalie, Voegele, Catherine, Webb, Penelope M., Feuchtinger, Corinna, Gioia, Lydie, Hall, Janet, Hashibe, Mia, Whitemanv, David C., Sangrajrang, Suleeporn, Herte, Barbara, McKay-Chopin, Sandrine, Thomas, Alun, Vallee, Maxime P., and Hopper, John L.

Subjects
Gene mutations -- Analysis, Human evolution -- Analysis, Ataxia telangiectasia -- Genetic aspects, Ataxia telangiectasia -- Research, Breast cancer -- Risk factors, Biological sciences
Abstract

Several case-studies are conducted to explain the rare and evolutionary ATM (ataxia telangiectasia [MIM 208900]) mutations, which usually lead to increase risk of breast cancer in humans. The breast cancer risk is shown to be highly enhanced by the protein-truncating and splice-junction variants of the ATM mutations.

Published
2009

50. Dose Estimation for the European Epidemiological Study on Pediatric Computed Tomography (EPI-CT)

Author

Thierry-Chef, Isabelle, primary, Ferro, Gilles, additional, Le Cornet, Lucian, additional, Dabin, Jérémie, additional, Istad, Tore S., additional, Jahnen, Andreas, additional, Lee, Choonsik, additional, Maccia, Carlo, additional, Malchair, Françoise, additional, Olerud, Hilde M., additional, Harbron, Richard W., additional, Figuerola, Jordi, additional, Hermen, Johannes, additional, Moissonnier, Monika, additional, Bernier, Marie-Odile, additional, de Basea, Magda Bosch, additional, Byrnes, Graham, additional, Cardis, Elisabeth, additional, Hauptmann, Michael, additional, Journy, Neige, additional, Kesminiene, Ausrele, additional, Meulepas, Johanna M., additional, Pokora, Roman, additional, and Simon, Steven L., additional

Published
2021
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