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We provide an overview of the status of Monte-Carlo event generators for high-energy particle physics. Guided by the experimental needs and requirements, we highlight areas of active development, and opportunities for future improvements. Particular emphasis is given to physics models and algorithms that are employed across a variety of experiments. These common themes in event generator development lead to a more comprehensive understanding of physics at the highest energies and intensities, and allow models to be tested against a wealth of data that have been accumulated over the past decades. A cohesive approach to event generator development will allow these models to be further improved and systematic uncertainties to be reduced, directly contributing to future experimental success. Event generators are part of a much larger ecosystem of computational tools. They typically involve a number of unknown model parameters that must be tuned to experimental data, while maintaining the integrity of the underlying physics models. Making both these data, and the analyses with which they have been obtained accessible to future users is an essential aspect of open science and data preservation. It ensures the consistency of physics models across a variety of experiments.

The enhancement of α elements such as oxygen is an important phase in the chemical evolution of the early Universe, with nebular material becoming enriched in these elements sooner than iron. Here, we present models which incorporate stellar spectra with α-enhanced compositions, focusing on the impact on the integrated light of young stellar populations, including those with large binary star fractions using the Binary Populations and Spectral Synthesis (bpass) framework, while using Solar-scaled stellar evolution models. We find that broad spectrum outputs such as production of ionizing flux, the ultraviolet spectral slope and optical colours are only weakly affected by a change in |$[\alpha /\rm {Fe}]$|⁠. A number of features such as ultraviolet line indices (e.g. at 1719 and 1853 Å) and optical line indices (such as MgB) are sensitive to such changes in composition for a continuously star-forming population and a single starburst population respectively. We find that at ages of more than 1 Gyr, α-enhanced stellar populations appear bluer than their Solar-scaled counterparts, and show expected sensitivity of optical line indices to composition, in agreement with previous work. The ultraviolet stellar absorption lines are relatively insensitive to subtleties in the abundances ratios, although with sufficient measurement precision, a combination of UV line indices may enable a simultaneous measurement of total metallicity mass fraction and |$[\alpha /\rm {Fe}]$| in young stellar populations. The output models are designated as bpass v2.3 and made available to the community with the aim of assisting interpretation of observations of high-redshift galaxies with the James Webb Space Telescope. [ABSTRACT FROM AUTHOR]

The authors have investigated Escherichia coli O157:H7. The results have demonstrated the prevalence of O157:H7 in fecal and tissue samples from the colons of downer dairy cattle than in those from healthy dairy cattle.

Abstract: Aim: Biofeedback is an established, effective and non‐invasive treatment for faecal incontinence (FI). The aim was to compare the effectiveness of four different biofeedback treatment regimes. Method: This was a randomized control trial of patients with FI, stratified into two groups (metropolitan and rural) and then randomized into two subgroups (groups 1 and 2 within metropolitan, groups 3 and 4 within rural) with varying face‐to‐face and telephone biofeedback components. All patients received standardized counselling and education, dietary modification and the use of anti‐diarrhoeal medications. Group 1 received four monthly face‐to‐face biofeedback treatments, groups 2 and 3 received one face‐to‐face biofeedback followed by telephone biofeedback and group 4 received a one‐off face‐to‐face biofeedback treatment. Primary outcomes were patient‐assessed severity of FI and quality of life as assessed by the 36‐item Short Form Health Survey and direct questioning of objectives. Secondary outcomes included St Mark's incontinence score, anxiety, depression and anorectal physiology measures (resting, squeeze pressures; isotonic, isometric fatigue times). Results: Between 2006 and 2012, 351 patients were recruited. One patient died leaving 350 for analysis. 332 (95%) were women. Mean age was 60 (SD = 14). All groups had significant improvements in FI, quality of life, incontinence score and mental status (P < 0.001 each). There were no differences in improvements in FI between groups although patient satisfaction was less with reduced face‐to‐face contact. There were modest improvements in isotonic and isometric fatigue times suggesting improved sphincter endurance (both P < 0.001). Conclusion: Biofeedback is effective for FI. Although face‐to‐face and telephone biofeedback is not necessary to improve FI, it is important for patient satisfaction. [ABSTRACT FROM AUTHOR]

The effect of 4% sodium lactate (NaL) in beefburger patty formulations on the survival and heat resistance of Escherichia coli O157:H7 was investigated. Fresh beef trimmings were inoculated with E. coli O157:H7 to a concentration of 6·0–7·0 log10 cfu g−1 and subjected to the processing stages of beefburger patty production. Two commercial beefburger patty formulations were produced: a ‘quality’ patty (100% beef) and an ‘economy’ patty (70% beef, 30% other ingredients, including onion, water, salt, seasoning, rusk and soya concentrate). Sodium lactate (4% w/v) was added to the beefburger patties during mincing and the formed patties were frozen and stored for 1 month. Beefburger patties without added NaL were used as controls. After frozen storage for 1 month, patties were examined for E. coli O157:H7 counts. There was a synergistic effect between freezing and NaL, which resulted in a small but significant reduction (P<0·05) (approximately 0·5 log10 cfu g−1) in E. coli O157:H7 numbers. The frozen beefburger patties were also heat-treated at 50, 55 and 60°C and the data analysed to derive D -values for E. coli O157:H7 cells. At each temperature treatment, theD -values of the quality and economy beefburger patties with 4% NaL were significantly lower (P<0·001) than the D -values of the patty formulations without NaL. The study demonstrates that the presence of 4% NaL in beefburger patty formulations can reduce the overall risks posed to consumers by the presence ofE. coli O157:H7 by, first; reducing pathogen survival during freezing and frozen storage of the uncooked product; and, second, by increasing the susceptibility of the pathogen to heat during normal cooking processes. [Copyright &y& Elsevier]

A needs assessment is a research and planning activity designed to determine a community's service needs and utilization patterns. One of the most practical ways to plan services is to gather information accurately about a defined population and use that information to revise existing programs or develop new ones. Unfortunately, needs assessment findings often go unused. This article describes how a needs assessment was designed to assess the need for hospice services in a rural Pennsylvania county and how the results of this assessment were useful in determining priorities for program planning and service development. The implications of a model needs assessment such as the one proposed are discussed. [ABSTRACT FROM AUTHOR]

The effects of commercial beef burger production and product formulation on the heat resistance of Escherichia coli O157:H7 (NCTC 12900) in beef burgers were investigated. Fresh beef trimmings were inoculated with E. coli O157:H7 to approximately log10 7.0 cfu g(-1) and subjected to standard beef burger production processes, including freezing, frozen storage and tempering. The tempered trimmings were processed in line with commercial practice to produce burgers of two formulations, a 'Quality' burger containing 100% beef and an 'Economy' burger containing 70% beef and 30% other ingredients (salt, seasoning, soya, onion and water). The burgers were then frozen and stored. Control 'unprocessed' burgers were produced to each of the above formulations using fresh beef trimmings. All burger types were heat-treated at 55, 60 or 65 degrees C. Samples were examined by plating on Tryptone Soya Agar (TSA), incubated at 37 degrees C for 2 h, before overlaying with SMAC (TSA/SMAC) and incubation at 37 degrees C. The resultant counts were used to derive D-values for E. coli O1 57:H7. At each treatment temperature, the D-values from each burger formulation using frozen tempered trimmings were significantly lower (P < 0.001) than the D-values from that formulation using fresh trimmings. At each treatment temperature, the D-values from Economy burgers using processed trimmings were significantly higher (P < 0.001) than the D-values from Quality burgers using processed trimmings. A similar trend of significantly higher (P<0.001) D-values for Economy burgers was observed using fresh trimmings. This study found that commercial processing and product formulation have profound effects on the heat resistance of E. coli O157:H7 in beef burgers.

The survival characteristics of Escherichia coli O157:H7 in silage derived from contaminated grass were investigated. The survival of other enteric bacteria was also investigated to determine if E. coli O157:H7 demonstrates enhanced acid tolerance in comparison. Samples of chopped grass were treated as follows: (i) no additive (control); (ii) inoculation with E. coli O157:H7 to a final concentration of log10 4.0 CFU g(-1); (iii) addition of an 85% solution of formic acid at 3.0 ml kg(-1) grass; and (iv) addition of both E. coli O157:H7 and formic acid, at the above concentrations. Treated 6-kg grass samples were packed into laboratory silos, sealed, and stored at 15 degrees C for up to 180 days. Individual replicate silos were removed from storage periodically and subjected to microbiological and chemical analyses. Chemical analyses of the silage samples indicated that lactic acid-dominant fermentations, with a rapid drop in pH, occurred. Numbers of enteric bacteria decreased from log10 7.0 to 8.0 CFU g(-1) to undetectable levels within 19 days' storage. E. coli O157:H7 did not survive the silage fermentation process, with numbers declining from approximately log10 4.0 CFU g(-1) to undetectable levels within 19 days of ensiling. The pattern of decline in numbers of E. coli O157:H7 was the same as that for the enteric bacteria, indicating that under the conditions tested, the acid tolerance of E. coli O157:H7 was not significantly different from the acid tolerance of other enteric bacteria. This study found that E. coli O157:H7 did not survive a good silage fermentation process, indicating that properly ensiled grass that is correctly stored is unlikely to be a vector for the transmission of the pathogen among cattle.

1. A person with mental illness, such as schizophrenia, can be mobilized to maintain hope. 2. A relationship seems to be the catalyst that allows hope to develop exponentially. 3. A belief in the client's abilities can be a powerful motivator for change.

A thermoluminescent dosimetry system was utilized to investigate how much the radiation dose is reduced through the addition of a niobium-based accessory filter to an X-ray unit's conventional aluminum filter. A two-bitewing series was exposed in a tissue-equivalent human phantom. The skin exposures from an X-ray beam with the added niobium filter and a beam with the aluminum filter alone were measured and compared. Thyroid dose distribution was also measured and similarly compared. Utilization of the niobium filter resulted in a significant reduction in skin exposure (p less than 0.001) of 14.8 per cent. Thyroid dose was not lessened by using the niobium filter, however. In fact, in one region of the thyroid it increased significantly.

The growth in the number of Medicare patients with end stage renal disease (ESRD) in New York State receiving cadaver kidney transplants in the 1980s substantially lagged behind growth in the nation. Compared to the United States, New Yorkers on dialysis had less access to transplants. The greatest decline in transplant rates was experienced by New York's black population. During the early and mid-1980s, considerable transplant rate growth in New York City was maintained, despite very slow growth in local kidney procurement, by importing kidneys from other states, by residents seeking transplants elsewhere, and by a greater proportion of transplants going to Medicare ESRD patients. Since 1986, the number of kidneys procured in New York City increased while the number procured nationally fell. However, kidney imports to New York City dropped dramatically and thus the number of cadaver transplants declined despite the growth in local procurement. Upstate, procurement and transplants started at a higher level, but grew even more slowly.