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1. Phase Memory of Orbital Angular Momentum in Multiple Scattering Environment

Author

Meglinski, Igor, Lopushenko, Ivan, Sdobnov, Anton, and Bykov, Alexander

Subjects
Physics - Optics
Abstract

Recent advancements in wavefront shaping techniques have facilitated the study of complex structured light's propagation with orbital angular momentum (OAM) within various media. The introduction of a spiral phase modulation to the Laguerre-Gaussian (LG) beam during its paraxial propagation is facilitated by the negative gradient of the medium's refractive index's temporal change, resulting in an accelerated retardation in OAM twist. This approach attains remarkable sensitivity to even the slightest variations in the medium's refractive index (10^(-6)). The phase memory of OAM is revealed as the ability of twisted light preserving initial helical phase even propagating through the turbid tissue-like multiple scattering medium. The results confirm fascinating opportunities of the exploiting OAM light in biomedical applications, e.g. such as non-invasive trans-cutaneous glucose diagnosis and optical communication through biological tissues and other optically dense media., Comment: To be published in Nature Photonics

Published
2023

2. Depolarization composition of the back-scattered circularly polarized light

Author

Lopushenko, Ivan, Bykov, Alexander, and Meglinski, Igor

Subjects
Physics - Optics
Abstract

We consider the origin of unpolarised light resulting from the backscattering of circularly polarized light by random turbid tissue-like disperse medium. We reveal the dynamics of the backscattered fraction of unpolarized light, disclosing its meticulous decomposition into two rigorously polarized components characterized by opposing helicities, with fully defined polarization states. Concurrently, their superposition, driven by multiple scattering within the medium, leads to the appearance of a fraction of linear polarization. We emphasize that in-depth binding of circular polarization memory of light with the helicity flips occurs within the scattering medium, meaning the conservation of spin angular momentum. We anticipate that the results obtained hold significant implications for future studies, particularly in the field of tissue polarimetry and light vortexes., Comment: To be published in Physical Review A: https://journals.aps.org/pra/

Published
2023

7. Terahertz-to-infrared converters for imaging the human skin cancer: challenges and feasibility

Author

Moldosanov, Kamil, Bykov, Alexander, Kairyev, Nurlanbek, Khodzitsky, Mikhail, Kropotov, Grigory, Lelevkin, Valery, Meglinski, Igor, Postnikov, Andrei, and Shakhmin, Alexey

Subjects
Physics - Medical Physics
Abstract

Purpose: The terahertz (THz) medical imaging is a promising noninvasive technique for monitoring the skin's conditions, early detection of the human skin cancer, and recovery from burns and wounds. It can be applied for visualization of healing process directly through clinical dressings and restorative ointments, minimizing the frequency of dressing changes. The THz imaging technique is cost effective, as compared to the magnetic resonance method. Our aim was to develop an approach capable of providing better image resolution than the commercially available THz imaging cameras. Approach: The terahertz-to-infrared (THz-to-IR) converters can visualize the human skin cancer by converting the latter's specific contrast patterns recognizable in THz radiation range into IR patterns, detectable by a standard IR imaging camera. At the core of suggested THz-to-IR converters are flat matrices transparent both in the THz range to be visualized and in the operating range of the IR camera; these matrices contain embedded metal nanoparticles, which, when irradiated with THz rays, convert the energy of THz photons into heat and become nanosources of IR radiation detectable by an IR camera. Results: The ways of creating the simplest converter, as well as a more complex converter with wider capabilities, are considered. The first converter is a gelatin matrix with gold 8.5 nm diameter nanoparticles, the second is a polystyrene matrix with 2 nm diameter nanoparticles from copper-nickel MONEL (c) alloy 404. Conclusions: An approach with a THz-to-IR converter equipped with an IR camera is promising in that it could provide a better image of oncological pathology than the commercially available THz imaging cameras do., Comment: 48 pages, 15 figures

Published
2023
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9. Machine Learning in Tissue Polarimetry

Author

Makkithaya, Kausalya Neelavara, Melanthota, Sindhoora Kaniyala, Kistenev, Yury V., Bykov, Alexander, Novikova, Tatiana, Meglinski, Igor, Mazumder, Nirmal, Gerstman, Bernard S., Editor-in-Chief, Aizawa, Masuo, Series Editor, Austin, Robert H., Series Editor, Barber, James, Series Editor, Berg, Howard C., Series Editor, Callender, Robert, Series Editor, Feher, George, Series Editor, Frauenfelder, Hans, Series Editor, Giaever, Ivar, Series Editor, Joliot, Pierre, Series Editor, Keszthelyi, Lajos, Series Editor, King, Paul W., Series Editor, Lazzi, Gianluca, Series Editor, Lewis, Aaron, Series Editor, Lindsay, Stuart M., Series Editor, Liu, Xiang Yang, Series Editor, Mauzerall, David, Series Editor, Mielczarek, Eugenie V., Series Editor, Niemz, Markolf, Series Editor, Parsegian, V. Adrian, Series Editor, Powers, Linda S., Series Editor, Prohofsky, Earl W., Series Editor, Rostovtseva, Tatiana K., Series Editor, Rubin, Andrew, Series Editor, Seibert, Michael, Series Editor, Tao, Nongjian, Series Editor, Thomas, David, Series Editor, Mazumder, Nirmal, editor, Kistenev, Yury V., editor, Borisova, Ekaterina, editor, and Prasada K., Shama, editor

Published
2023
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11. Machine Learning in Tissue Polarimetry

Author

Makkithaya, Kausalya Neelavara, primary, Melanthota, Sindhoora Kaniyala, additional, Kistenev, Yury V., additional, Bykov, Alexander, additional, Novikova, Tatiana, additional, Meglinski, Igor, additional, and Mazumder, Nirmal, additional

Published
2023
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14. Materials and Research Methods

Author

Bachinsky, Victor, Vanchulyak, Oleh Ya, Ushenko, Alexander G., Ushenko, Yurii A., Dubolazov, Alexander V., Bykov, Alexander, Hogan, Benjamin, Meglinski, Igor, Bachinsky, Victor, Vanchulyak, Oleh Ya, Ushenko, Alexander G., Ushenko, Yurii A., Dubolazov, Alexander V., Bykov, Alexander, Hogan, Benjamin, and Meglinski, Igor

Published
2021
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15. Scale-Selective and Spatial-Frequency Correlometry of Polarization-Inhomogeneous Field

Author

Meglinski, Igor, Trifonyuk, Liliya, Bachinsky, Victor, Vanchulyak, Oleh, Bodnar, Boris, Sidor, Maxim, Dubolazov, Olexander, Ushenko, Alexander, Ushenko, Yurii, Soltys, Irina V., Bykov, Alexander, Hogan, Benjamin, Novikova, Tatiana, Meglinski, Igor, Trifonyuk, Liliya, Bachinsky, Victor, Vanchulyak, Oleh, Bodnar, Boris, Sidor, Maxim, Dubolazov, Olexander, Ushenko, Alexander, Ushenko, Yurii, Soltys, Irina V., Bykov, Alexander, Hogan, Benjamin, and Novikova, Tatiana

Published
2021
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16. Polarization Correlometry of Microscopic Images of Polycrystalline Networks Biological Layers

Author

Meglinski, Igor, Trifonyuk, Liliya, Bachinsky, Victor, Vanchulyak, Oleh, Bodnar, Boris, Sidor, Maxim, Dubolazov, Olexander, Ushenko, Alexander, Ushenko, Yurii, Soltys, Irina V., Bykov, Alexander, Hogan, Benjamin, Novikova, Tatiana, Meglinski, Igor, Trifonyuk, Liliya, Bachinsky, Victor, Vanchulyak, Oleh, Bodnar, Boris, Sidor, Maxim, Dubolazov, Olexander, Ushenko, Alexander, Ushenko, Yurii, Soltys, Irina V., Bykov, Alexander, Hogan, Benjamin, and Novikova, Tatiana

Published
2021
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17. Methods and Means of Polarization Correlation of Fields of Laser Radiation Scattered by Biological Tissues

Author

Meglinski, Igor, Trifonyuk, Liliya, Bachinsky, Victor, Vanchulyak, Oleh, Bodnar, Boris, Sidor, Maxim, Dubolazov, Olexander, Ushenko, Alexander, Ushenko, Yurii, Soltys, Irina V., Bykov, Alexander, Hogan, Benjamin, Novikova, Tatiana, Meglinski, Igor, Trifonyuk, Liliya, Bachinsky, Victor, Vanchulyak, Oleh, Bodnar, Boris, Sidor, Maxim, Dubolazov, Olexander, Ushenko, Alexander, Ushenko, Yurii, Soltys, Irina V., Bykov, Alexander, Hogan, Benjamin, and Novikova, Tatiana

Published
2021
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18. Multifunctional Stokes Correlometry of Biological Layers

Author

Meglinski, Igor, Trifonyuk, Liliya, Bachinsky, Victor, Vanchulyak, Oleh, Bodnar, Boris, Sidor, Maxim, Dubolazov, Olexander, Ushenko, Alexander, Ushenko, Yurii, Soltys, Irina V., Bykov, Alexander, Hogan, Benjamin, Novikova, Tatiana, Meglinski, Igor, Trifonyuk, Liliya, Bachinsky, Victor, Vanchulyak, Oleh, Bodnar, Boris, Sidor, Maxim, Dubolazov, Olexander, Ushenko, Alexander, Ushenko, Yurii, Soltys, Irina V., Bykov, Alexander, Hogan, Benjamin, and Novikova, Tatiana

Published
2021
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19. Materials and Methods

Author

Meglinski, Igor, Trifonyuk, Liliya, Bachinsky, Victor, Vanchulyak, Oleh, Bodnar, Boris, Sidor, Maxim, Dubolazov, Olexander, Ushenko, Alexander, Ushenko, Yurii, Soltys, Irina V., Bykov, Alexander, Hogan, Benjamin, Novikova, Tatiana, Meglinski, Igor, Trifonyuk, Liliya, Bachinsky, Victor, Vanchulyak, Oleh, Bodnar, Boris, Sidor, Maxim, Dubolazov, Olexander, Ushenko, Alexander, Ushenko, Yurii, Soltys, Irina V., Bykov, Alexander, Hogan, Benjamin, and Novikova, Tatiana

Published
2021
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22. Effect of the Presence of Oxysolvents on Compositions and Structures of Silver(I) Complexes with Boron Cluster Anion [B12Cl12]2–

Author

Golubev, Alexey V., primary, Kubasov, Alexey S., additional, Malinina, Elena A., additional, Nikiforova, Svetlana E., additional, Goeva, Lyudmila V., additional, Avdeeva, Varvara V., additional, Bykov, Alexander Yu., additional, Novikov, Roman A., additional, Zhizhin, Konstantin Yu., additional, and Kuznetsov, Nikolay T., additional

Published
2024
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23. Cross-Bridge Induced Adhesion of Red Blood Cells Assessed by Optical Tweezers

Author

Popov, Alexey, Avsievich, Tatiana, Bykov, Alexander, and Meglinski, Igor

Subjects
Physics - Biological Physics
Abstract

The reversible aggregation of red blood cells (RBCs) is a process of erythrocytes clumping that strongly influences the rheological properties of blood. The adhesion of RBCs has been studied extensively in the frame of cell-to-cell interaction induced by dextran macromolecules, whereas the data is lacking for native plasma solution. We apply optical tweezers to investigate the induced adhesion of RBCs in plasma and in dextran solution. Two hypotheses 'cross-bridges' and 'depletion layer' are being utilized to describe the mechanism of cells interaction, while both need to be confirmed experimentally. The results show that in dextran solution the interaction of adhering RBCs agrees well with the quantitative predictions obtained on the basis of a depletion-induced cells adhesion model, whereas a migrating 'cross-bridge' model is more appropriate for plasma. Furthermore, the 'cross-bridge' mechanism is confirmed by direct visualization of red blood cells adhesion utilizing scanning electron microscopy (SEM)., Comment: 4 pages, 3 figures

Published
2017

30. List of contributors

Author

Abdulbari, Hayder A., primary, Ahmed Mahdy, Dalia Samir, additional, Akgönüllü, Semra, additional, Akther, Fahima, additional, Alam, Mohammad Feroz, additional, Alarifi, Ibrahim M., additional, Amir, Sidra, additional, Avsievich, Tatiana, additional, Bereli, Nilay, additional, Bilal, Muhammad, additional, Bykov, Alexander, additional, Chidangil, Santhosh, additional, Denizli, Adil, additional, Ferenz, Katja, additional, Hari, Sowmya, additional, Hayat, Sumreen, additional, Jamil, Dzuliana Fatin, additional, Karaman, Ozan, additional, Khurshid, Mohsin, additional, Lukose, Jijo, additional, Mayer, Christian, additional, Meenambiga, Setti Sudharsan, additional, Meglinski, Igor, additional, Mohan, Ganesh, additional, Muzammil, Saima, additional, Nguyen, Nam-Trung, additional, Phang, Yoong Sheng, additional, Popov, Alexey, additional, Rahman, Khaliqur, additional, Roslan, Rozaini, additional, Sakthiselvan, Punniavan, additional, Saylan, Yeşeren, additional, Shah, Shah Bahrullah, additional, Shahid, Aqsa, additional, Shastry, Shamee, additional, Ta, Hang T., additional, Tabak, Ahmet Fatih, additional, Tran, Huong D.N., additional, Uddin, Salah, additional, Umai, Devasena, additional, Xu, Zhi Ping, additional, Yadav, Sunishtha S., additional, Yang, Yanjun, additional, Yasmeen, Humaira, additional, Yavuz, Handan, additional, Zain, Maryam, additional, Zhang, Jun, additional, Zhao, Yiping, additional, Zhu, Ruixue, additional, and Zulfiqar, Aimen, additional

Published
2022
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32. Carboxonium derivatives based on closo-dodecaborate anions [1,2-B12H10O2CR]−: synthesis and molecular orbital analysis.

Author

Kolbunova, Anastasia V., Klyukin, Ilya N., Novikov, Alexander S., Nelyubin, Alexey V., Zhdanov, Andrey P., Kubasov, Alexey S., Selivanov, Nikita A., Bykov, Alexander Yu., Zhizhin, Konstantin Yu., and Kuznetsov, Nikolay T.

Subjects
MOLECULAR orbitals, ANIONS, IONS, CARBOXYLIC acids
Abstract

Borylated carboxonium ions based on closo-dodecaborate anions were obtained by studying the interaction of [B12H12]2− with some carboxylic acids (RCOOH, R = CH3, C2H5, C3H7, and C6H5) in the presence of electrophilic inducers. Several electrophilic inducers were tested, and the best results were achieved with BF3*(C2H5)2O. It was established that, as in the case of closo-decaborate carboxonium derivatives, the process of [1,2-B12H10O2CR]− preparation occurs through the formation of the monosubstituted carboxonium derivative [B12H11OC(OR′)R]−, where R′ = H and C2H5. The structures of the tetrabutylammonium salts of the carboxonium derivative ((C4H9)4N)[1,2-B12H10O2CR] were established with the help of X-ray structure analysis. Comprehensive molecular orbital (MO) analysis was also carried out, and the nature of the interaction between the cluster cage and organic moiety was analysed theoretically. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Exploring the evolution of circular polarized light backscattered from turbid tissue-like disperse medium utilizing generalized Monte Carlo modeling approach with a combined use of Jones and Stokes--Mueller formalisms.

Author

Lopushenko, Ivan, Sieryi, Oleksii, Bykov, Alexander, and Meglinski, Igor

Subjects
OPTICAL instruments, LIGHT propagation, COHERENCE (Optics), CERVICAL intraepithelial neoplasia, POLARIMETRY, ALZHEIMER'S disease
Abstract

Significance: Phase retardation of circularly polarized light (CPL), backscattered by biological tissue, is used extensively for quantitative evaluation of cervical intraepithelial neoplasia, presence of senile Alzheimer's plaques, and characterization of biotissues with optical anisotropy. The Stokes polarimetry and Mueller matrix approaches demonstrate high potential in definitive non-invasive cancer diagnosis and tissue characterization. The ultimate understanding of CPL interaction with tissues is essential for advancing medical diagnostics, optical imaging, therapeutic applications, and the development of optical instruments and devices. Aim: We investigate propagation of CPL within turbid tissue-like scattering medium utilizing a combination of Jones and Stokes--Mueller formalisms in a Monte Carlo (MC) modeling approach. We explore the fundamentals of CPL memory effect and depolarization formation. Approach: The generalized MC computational approach developed for polarization tracking within turbid tissue-like scattering medium is based on the iterative solution of the Bethe--Salpeter equation. The approach handles helicity response of CPL scattered in turbid medium and provides explicit expressions for assessment of its polarization state. Results: Evolution of CPL backscattered by tissue-like medium at different conditions of observation in terms of source--detector configuration is assessed quantitatively. The depolarization of light is presented in terms of the coherence matrix and Stokes--Mueller formalism. The obtained results reveal the origins of the helicity flip of CPL depending on the source--detector configuration and the properties of the medium and are in a good agreement with the experiment. Conclusions: By integrating Jones and Stokes--Mueller formalisms, the combined MC approach allows for a more complete representation of polarization effects in complex optical systems. The developed model is suitable to imitate propagation of the light beams of different shape and profile, including Gaussian, Bessel, Hermite--Gaussian, and Laguerre--Gaussian beams, within tissue-like medium. Diverse configuration of the experimental conditions, coherent properties of light, and peculiarities of polarization can be also taken into account. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Incremental residual polarization caused by aging in human skin.

Author

Dremin, Viktor, Zharkikh, Elena, Lopushenko, Ivan, Marcinkevics, Zbignevs, Bykov, Alexander, and Meglinski, Igor

Subjects
SKIN aging, MONTE Carlo method, LINEAR polarization, SKIN, BLOOD volume, TISSUES
Abstract

Significance: The study of the effect of aging on the optical properties of biological tissues, in particular polarization, is important in the development of new diagnostic approaches. Aim: This work aims to provide a comprehensive analysis of the factors and mechanisms that contribute to the alteration of skin polarization properties caused by aging, using polarization-sensitive hyperspectral imaging measurements and Monte Carlo simulation. Approach: Our investigation involved both experimental studies of in vivo human skin of volunteers of different ages and computational modeling that accounted for changes in the absorption and scattering properties of the skin model. Specifically, we analyzed alterations in the degree of linear polarization (DOLP) to better understand the impact of aging on skin polarization properties. Results: A statistically significant increase in the DOLP was found for the elderly group. At the same time, there was no correlation between changes in polarization and the calculated blood volume fraction parameter for different ages. According to the simulation results, it was also found that a change in the scattering properties of biological tissues has a more significant effect on the change in polarizing light compared to the change in absorption. Conclusions: The results of the work prove that the sensitivity of polarization imaging to age- or pathological-related skin changes may be primarily due to changes in scattering, which in turn is associated with changes in the collagen fibers of the dermis. The proposed technique shows promise for in vivo non-invasive real-time assessment of age-associated skin changes and can also be extended to monitor changes associated with the development of age-related pathologies. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Optical Wireless Data Transfer Through Biotissues: Practical Evidence and Initial Results

Author

Ahmed, Iqrar, Bykov, Alexander, Popov, Alexey, Meglinski, Igor, Katz, Marcos, Akan, Ozgur, Editorial Board Member, Bellavista, Paolo, Editorial Board Member, Cao, Jiannong, Editorial Board Member, Coulson, Geoffrey, Editorial Board Member, Dressler, Falko, Editorial Board Member, Ferrari, Domenico, Editorial Board Member, Gerla, Mario, Editorial Board Member, Kobayashi, Hisashi, Editorial Board Member, Palazzo, Sergio, Editorial Board Member, Sahni, Sartaj, Editorial Board Member, Shen, Xuemin (Sherman), Editorial Board Member, Stan, Mircea, Editorial Board Member, Jia, Xiaohua, Editorial Board Member, Zomaya, Albert Y., Editorial Board Member, Mucchi, Lorenzo, editor, Hämäläinen, Matti, editor, Jayousi, Sara, editor, and Morosi, Simone, editor

Published
2019
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46. Methods and Means of Polarization Correlation of Fields of Laser Radiation Scattered by Biological Tissues

Author

Meglinski, Igor, primary, Trifonyuk, Liliya, additional, Bachinsky, Victor, additional, Vanchulyak, Oleh, additional, Bodnar, Boris, additional, Sidor, Maxim, additional, Dubolazov, Olexander, additional, Ushenko, Alexander, additional, Ushenko, Yurii, additional, Soltys, Irina V., additional, Bykov, Alexander, additional, Hogan, Benjamin, additional, and Novikova, Tatiana, additional

Published
2021
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47. Multifunctional Stokes Correlometry of Biological Layers

Author

Meglinski, Igor, primary, Trifonyuk, Liliya, additional, Bachinsky, Victor, additional, Vanchulyak, Oleh, additional, Bodnar, Boris, additional, Sidor, Maxim, additional, Dubolazov, Olexander, additional, Ushenko, Alexander, additional, Ushenko, Yurii, additional, Soltys, Irina V., additional, Bykov, Alexander, additional, Hogan, Benjamin, additional, and Novikova, Tatiana, additional

Published
2021
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50. Materials and Methods

Author

Meglinski, Igor, primary, Trifonyuk, Liliya, additional, Bachinsky, Victor, additional, Vanchulyak, Oleh, additional, Bodnar, Boris, additional, Sidor, Maxim, additional, Dubolazov, Olexander, additional, Ushenko, Alexander, additional, Ushenko, Yurii, additional, Soltys, Irina V., additional, Bykov, Alexander, additional, Hogan, Benjamin, additional, and Novikova, Tatiana, additional

Published
2021
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