1. Response to growth hormone treatment in very young patients with growth hormone deficiencies and mini-puberty
- Author
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Zeynep Şıklar, Zehra Aycan, Filiz Mine Çizmecioğlu Jones, Enver Simsek, Meltem Tayfun, Semra Çetinkaya, Mehmet Nuri Ozbek, Eda Mengen, Erdal Adal, Metin Yildiz, Merih Berberoğlu, Iffet Bircan, Oya Ercan, Sukran Poyrazoglu, Firdevs Bas, Şenay Savaş Erdeve, Semih Bolu, Abdullah Bereket, Muammer Buyukinan, Ayhan Abaci, Feyza Darendeliler, Saygin Abali, Şükran Darcan, Esra D. Papatya, Çukurova Üniversitesi, Cetinkaya, Semra, Erdeve, Senay Savas Hlth Sci Univ, Hlth Implementat & Res Ctr, Dr Sami Ulus Obstet & Gynecol, Dept Pediat Endocrinol,Childrens Hlth & Dis, Ankara, Turkey, Poyrazoglu, Sukran, Bas, Firdevs, Darendeliler, Feyza Istanbul Univ, Inst Child Hlth, Fac Med, Dept Pediat Endocrinol, Istanbul, Turkey, Ercan, Oya Istanbul Univ, Cerrahpasa Med Fac, Dept Pediat Endocrinol, Istanbul, Turkey, Yildiz, Metin Goztepe Training & Res Hosp, Clin Pediat Endocrinol, Istanbul, Turkey, Adal, Erdal Istanbul Medipol Univ, Dept Pediat Endocrinol, Istanbul, Turkey, Bereket, Abdullah, Abali, Saygin Marmara Univ, Fac Med, Dept Pediat Endocrinol, Istanbul, Turkey, Aycan, Zehra Childrens Hlth & Dis Training & Res Hosp, Dr Sami Ulus Obstet & Gynecol, Dept Pediat Endocrinol, Ankara, Turkey, Aycan, Zehra Yildirim Beyazit Univ, Fac Med, Ankara, Turkey, Berberoglu, Merih, Siklar, Zeynep Ankara Univ, Sch Med, Dept Pediat Endocrinol, Ankara, Turkey, Tayfun, Meltem Ankara Childrens Hematol & Oncol Res & Training H, Dept Pediat Endocrinol, Ankara, Turkey, Darcan, Sukran Ege Univ, Fac Med, Dept Pediat Endocrinol, Izmir, Turkey, Mengen, Eda Cukurova Univ, Fac Med, Dept Pediat Endocrinol, Adana, Turkey, Bircan, Iffet Akdeniz Univ, Fac Med, Dept Pediat Endocrinol, Antalya, Turkey, Jones, Filiz Mine Cizmecioglu Kocaeli Univ, Fac Med, Dept Pediat Endocrinol, Kocaeli, Turkey, Simsek, Enver Osmangazi Univ, Fac Med, Dept Pediat Endocrinol, Eskisehir, Turkey, Papatya, Esra Deniz Bakirkoy Dr Sadi Konuk Educ & Res Hosp, Clin Pediat Endocrinol, Istanbul, Turkey, Ozbek, Mehmet Nuri Hlth Sci Univ, Gazi Yasargil Educ & Training Hosp, Clin Pediat Endocrinol, Diyarbakir, Turkey, Bolu, Semih Duzce Univ, Fac Med, Dept Pediat Endocrinol, Konuralp, Duzce, Turkey, Abaci, Ayhan Dokuz Eylul Univ, Fac Med, Dept Pediat Endocrinol, Izmir, Turkey, Buyukinan, Muammer Konya Educ & Res Hosp, Clin Pediat Endocrinol, Konya, Turkey, ABALI, SAYGIN -- 0000-0001-6552-2801, and Abaci, Ayhan -- 0000-0002-1812-0321
- Subjects
Male ,growth hormone deficiency ,medicine.medical_specialty ,Turkey ,Hormone Replacement Therapy ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,growth response ,Weight Gain ,Growth hormone ,Hypopituitarism ,Growth hormone deficiency ,Cohort Studies ,03 medical and health sciences ,Child Development ,0302 clinical medicine ,Endocrinology ,Isolated GH Deficiency ,030225 pediatrics ,Internal medicine ,Humans ,Medicine ,infancy ,Dwarfism, Pituitary ,Retrospective Studies ,Puberty, Delayed ,Sex Steroid Hormones ,Human Growth Hormone ,business.industry ,Hypogonadism ,Age Factors ,Infant ,growth hormone treatment ,medicine.disease ,Mini Puberty ,Body Height ,Hypoglycemia ,Recombinant Proteins ,mini-puberty ,Growth hormone treatment ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Cohort ,IGHD ,Female ,medicine.symptom ,business ,Weight gain - Abstract
PubMedID: 29353264 The aim of the study was to assess the response to growth hormone (GH) treatment in very young patients with GH deficiency (GHD) through a national, multi-center study. Possible factors affecting growth response were assessed (especially mini-puberty). Medical reports of GHD patients in whom treatment was initiated between 0 and 3 years of age were retrospectively evaluated. The cohort numbered 67. The diagnosis age was 12.4±8.6 months, peak GH stimulation test response (at diagnosis) as 1.0±1.4 ng/mL. The first and second years length gain was 15.0±4.3 and 10.4±3.4 cm. Weight gain had the largest effect on first year growth response; whereas weight gain and GH dose were both important factors affecting second year growth response. In the multiple pituitary hormone deficiency (MPHD) group (n=50), first year GH response was significantly greater than in the isolated GH deficiency (IGHD) group (n=17) (p=0.030). In addition first year growth response of infants starting GH between 0 and 12 months of age (n=24) was significantly greater than those who started treatment between 12 and 36 months of age (n=43) (p
- Published
- 2018