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1. A multifunctional probe station for in situ modification and study of quasi 1-d nanostructures in wide temperature and pressure ranges

Author

Dmitriev, Serghei, Button, B, and Kolmakov, A.

Subjects
Physics, QC1-999, Electronics, TK7800-8360
Abstract

An ultra high vacuum probe station has been designed for a wide range of electrophysical characterizations of individual nanostructures and nanostructure devices. The micro and nanostructures can be studied at different temperatures under vacuum and in a controllable gas environment. The surface of these nanostructures can be functionalized in situ with different catalysts; thus, the performance of the same nanostructure before and after functionalization can be compared directly. The system allows the nanostructures to be treated in situ with electron, ion, and photon (IR–UV range) beams for controlled defect formation, cleaning, and photochemical studies. The potential capabilities of this probe station were demonstrated using pristine and functionalized SnO2, In2O3, and TiO2 nanostructures.

Published
2011

5. Holographic k-string Tensions in Higher Representations and Luescher Term Universality

Author

Button, B., Lee, S. J., Zayas, L. A. Pando, Rodgers, V., and Stiffler, K.

Subjects
High Energy Physics - Theory, High Energy Physics - Lattice
Abstract

We investigate a holographic description of k-strings in higher representations via D5 branes with worldvolume fluxes. The D-brane configurations are embedded in supergravity backgrounds dual to confining field theories in 3 and 4 dimensions. We compute the tensions and find qualitative agreement for the totally symmetric and totally anti-symmetric representations with the results of other methods such as lattice as well as the Hamiltonian approach of Karabali and Nair. A one-loop computation on the D-brane configurations yields the Luescher term and allows us to confirm a previously proposed universal expression following from holography., Comment: 32 pages, 2 figures, 1 table. v2 references added; comparison with other methods enhanced

Published
2012
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11. Physical activity assessment in cystic fibrosis: A position statement

Author

Alison, J., Arets, B., Boas, S., Bradley, J., Button, B., Bye, P., Cerny, F., Cooper, D., Downs, A.M., Dwyer, T., Forster, E., Gallagher, C., Gruber, W., Hebestreit, A., Hebestreit, H., Huber, M., Hulzebos, E., Johnstone, Z., Lands, L., Lannefors, L., Lessine, F., Lindblad, A., Lowman, J., Mandrusiak, A., Martensson, M., McIlwaine, M., Möller, A., Molloy, M., Montgomery, G., Morrison, L., Murray, J., Nippins, M., Orenstein, D., Prasaad, A., Renner, S., Salhberg, M., Schneiderman, J.E., Swisher, A., Urquhart, D., Zeitoun, M.L., Bradley, Judy, O'Neill, Brenda, Kent, Lisa, Hulzebos, Erik H.J., Arets, Bert, and Hebestreit, Helge

Published
2015
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12. 404 Why are mucins so gigantic, and is it rational to sever them to aid mucus clearance?

Author

Livraghi-Butrico, A., primary, Grubb, B., additional, Carpenter, J., additional, Danielsen, S., additional, Markovetz, M., additional, Chen, G., additional, Radicioni, G., additional, Saldana-Montavon, A., additional, Sun, L., additional, Gutay, M., additional, Vilar, J., additional, Ehre, C., additional, Thornton, D., additional, Cowley, D., additional, O'Neal, W., additional, Hill, D., additional, Button, B., additional, Kesimer, M., additional, Rubinstein, M., additional, and Boucher, R., additional

Published
2022
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16. P231 Steps Ahead: optimising physical activity in adults with cystic fibrosis - a pilot randomised trial using wearable technology, goal setting and text message feedback

Author

Tierney, A., primary, Curran, M., additional, Collins, L., additional, Kennedy, L., additional, McDonnell, C., additional, Jurascheck, A., additional, Sheikhi, A., additional, Walsh, C., additional, Button, B., additional, Casserly, B., additional, and Cahalan, R., additional

Published
2022
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17. Markers of Sputum Dehydration Modify the Response to Long-Term Ozone Exposure in Individuals with and At-Risk of COPD

Author

Paulin, L.M., primary, Alexis, N.E., additional, Woo, H., additional, Liu, C., additional, Kesimer, M., additional, Button, B., additional, Pirozzi, C.S., additional, Paine, R., additional, Galiatsatos, P., additional, Tejwani, V., additional, Fawzy, A., additional, Gassett, A., additional, Kirwa, K., additional, Kaufman, J.D., additional, and Hansel, N.N., additional

Published
2022
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18. Web-based physical activity promotion in CF: A clinical trial.

Author

Cox N., Eldridge B., Rawlings S., Dreger J., Corda J., Hauser J., Button B., Bishop J., Nichols A., Middleton A., Ward N., Dwyer T., Dentice R., Lazarus R., O'Halloran P., Lee J., Mellerick C., Mackintosh K., McNarry M., Williams C., Holland A., Cox N., Eldridge B., Rawlings S., Dreger J., Corda J., Hauser J., Button B., Bishop J., Nichols A., Middleton A., Ward N., Dwyer T., Dentice R., Lazarus R., O'Halloran P., Lee J., Mellerick C., Mackintosh K., McNarry M., Williams C., and Holland A.

Abstract

Introduction/Aim: Physical activity levels are known to decline following hospitalization for people with cystic fibrosis (CF). However, optimal physical activity promotion strategies are unclear. This study investigated the effect of a web-based application (ActivOnline) in promoting physical activity in young people with CF. Method(s): A multi-centre RCT with assessor blinding and qualitative evaluation was undertaken at eight tertiary CF centres in Australia. People with CF (12-35 years) admitted to hospital for a respiratory cause were eligible and randomized to the 12-week ActivOnline intervention (AO) or usual care (UC). The primary outcome was change in devicebased time spent in moderate-to-vigorous physical activity (MVPA) from baseline to post-intervention. Follow-up was at six-months from hospital discharge when qualitative evaluation was undertaken. Healthcare utilization over 12-months was also reported. Result(s): 107 participants were randomized to AO (n = 52) or UC (n = 55). Sixty-three participants (59%) contributed to the intention to treat analysis. Mean (SD) age was 21(6) years (n = 46 < 18 years). At baseline physical activity levels were high in both groups (AO 102(52) vs. UC 127 (73) min.Day-1). There was no difference in MVPA between groups at either time-point (post-intervention mean difference (MD) (95%CI) -14 min (-45 to 16)). Uptake of the intervention was low with only 40% (n = 21) of participants accessing the web-application. During 12 months of follow-up relative risk of all-cause hospitalization in the AO group versus UC group was 0.8 (95%CI 0.51-1.27). Conclusion(s): A web-based application, including individualized goal-setting, real-time feedback and motivation for behaviour change, was no better than usual care at promoting physical activity in young people with CF following discharge from hospital. High levels of baseline physical activity levels in both groups, and limited engagement with the intervention, suggest alternative st

Published
2022

19. The Exeter Activity Unlimited statement on physical activity and exercise for cystic fibrosis: methodology and results of an international, multidisciplinary, evidence-driven expert consensus.

Author

Williams, CA, Barker, AR, Denford, S, van Beurden, SB, Bianchim, MS, Caterini, JE, Cox, NS, Mackintosh, KA, McNarry, MA, Rand, S, Schneiderman, JE, Wells, GD, Anderson, P, Beever, D, Beverley, Z, Buckley, R, Button, B, Causer, AJ, Curran, M, Dwyer, TJ, Gordon, W, Gruet, M, Harris, RA, Hatziagorou, E, Erik Hulzebos, HJ, Kampouras, A, Morrison, L, Cámara, MN, Reilly, CM, Sawyer, A, Saynor, ZL, Shelley, J, Spencer, G, Stanford, GE, Urquhart, DS, Young, R, Tomlinson, OW, Youth Activity Unlimited – A Strategic Research Centre of the UK Cystic Fibrosis Trust, Williams, CA, Barker, AR, Denford, S, van Beurden, SB, Bianchim, MS, Caterini, JE, Cox, NS, Mackintosh, KA, McNarry, MA, Rand, S, Schneiderman, JE, Wells, GD, Anderson, P, Beever, D, Beverley, Z, Buckley, R, Button, B, Causer, AJ, Curran, M, Dwyer, TJ, Gordon, W, Gruet, M, Harris, RA, Hatziagorou, E, Erik Hulzebos, HJ, Kampouras, A, Morrison, L, Cámara, MN, Reilly, CM, Sawyer, A, Saynor, ZL, Shelley, J, Spencer, G, Stanford, GE, Urquhart, DS, Young, R, Tomlinson, OW, and Youth Activity Unlimited – A Strategic Research Centre of the UK Cystic Fibrosis Trust

Abstract

BACKGROUND: The roles of physical activity (PA) and exercise within the management of cystic fibrosis (CF) are recognised by their inclusion in numerous standards of care and treatment guidelines. However, information is brief, and both PA and exercise as multi-faceted behaviours require extensive stakeholder input when developing and promoting such guidelines. METHOD: On 30th June and 1st July 2021, 39 stakeholders from 11 countries, including researchers, healthcare professionals and patients participated in a virtual conference to agree an evidence-based and informed expert consensus about PA and exercise for people with CF. This consensus presents the agreement across six themes: (i) patient and system centred outcomes, (ii) health benefits, iii) measurement, (iv) prescription, (v) clinical considerations, and (vi) future directions. The consensus was achieved by a stepwise process, involving: (i) written evidence-based synopses; (ii) peer critique of synopses; (iii) oral presentation to consensus group and peer challenge of revised synopses; and (iv) anonymous voting on final proposed synopses for adoption to the consensus statement. RESULTS: The final consensus document includes 24 statements which surpassed the consensus threshold (>80% agreement) out of 30 proposed statements. CONCLUSION: This consensus can be used to support health promotion by relevant stakeholders for people with CF.

Published
2022

40. Defective Epithelial Mucociliary Differentiation Leads to Mucin Hyperconcentration in the Autosomal Dominant Hyper Ige Syndrome (AD-HIES) Airways

Author

Chen, G., primary, Sun, L., additional, Esther, C.R., additional, Wolfgang, M., additional, Kesimer, M., additional, Hill, D., additional, Ramsey, K.A., additional, Button, B., additional, Quinney, N., additional, Gentzsch, M., additional, O'Neal, W.K., additional, Freeman, A., additional, Robinson, C., additional, Bogdanovski, K., additional, Olivier, K.N., additional, and Boucher, R.C., additional

Published
2020
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45. Inhibition of ATP hydrolysis restores airway surface liquid production in cystic fibrosis airway epithelia

Author

Stephan, H., Alexis, N.E., Morton, L.C., O'Neal, W.K., Ceppe, A., Donaldson, S., Lazarowski, E.R., Anderson, W.H., Button, B., Dang, H., Boucher, R.C., and van Heusden, C.

Subjects
cystic fibrosis, ecto-ATPases, Extracellular ATP, purinergic receptors, polyoxometalates
Abstract

Airway surface dehydration is a pathological feature of cystic fibrosis (CF) lung disease. 20 CF is caused by mutations in the CF transmembrane conductance regulator (CFTR), a cyclic 21 AMP-regulated Cl- channel controlled in part by the adenosine A2B receptor. An alternative, 22 CFTR-independent mechanism of fluid secretion is regulated by ATP, via the P2Y2 receptor 23 (P2Y2R) that activates Ca2+-regulated Cl- channels (CaCC/TMEM16) and inhibits Na+ 24 absorption. However, due to rapid ATP hydrolysis, steady-state ATP levels in CF airway surface 25 liquid (ASL) are inadequate to maintain P2Y2R-mediated fluid secretion. Therefore, inhibiting 26 airway epithelial ecto-ATPases to increase ASL ATP levels constitutes a strategy to restore 27 airway surface hydration in CF. Using [γ32P]ATP as radiotracer, we assessed the effect of a 28 series of ATPase inhibitory compounds on the stability of physiologically occurring ATP 29 concentrations. We identified the polyoxometalate [Co4(H2O)2(PW9O34)2]10- (POM-5) as the 30 most potent and effective ecto-ATPase inhibitor in CF airway epithelial cells. POM-5 caused 31 long-lasting inhibition of ATP hydrolysis in airway epithelia, which was reversible upon removal 32 of the inhibitor. Importantly, POM-5 markedly enhanced steady-state levels of released ATP, 33 promoting increased ASL volume in CF cell surfaces. These results provide proof-of-concept for 34 ecto-ATPase inhibitors as therapeutic agents to restore hydration of CF airway surfaces. As a test 35 of this notion, cell-free sputum supernatants from CF subjects were studied and found to have 36 abnormally elevated ATPase activity, which was markedly inhibited by POM-5.

Published
2020

50. The International Network for Evaluating Outcomes (iNeo) of neonates: evolution, progress and opportunities

Author

Shah, PS, Lui, K, Reichman, B, Norman, M, Kusuda, S, Lehtonen, L, Adams, M, Vento, M, Darlow, BA, Modi, N, Rusconi, F, Hakansson, S, San Feliciano, L, Helenius, KK, Bassler, D, Hirano, S, Lee, SK, Marshall, P, Schmidt, P, Dhawan, A, Craven, P, De Waal, K, Simmer, K, Gill, A, Pillow, J, Stack, J, Birch, P, Cooke, L, Casalaz, D, Holberton, J, Stewart, A, Downe, L, Stewart, M, Bajuk, B, Berry, A, Hunt, R, Kilburn, C, De Paoli, T, Bolisetty, S, Paradisis, M, Rieger, I, Koorts, P, Kuschel, C, Numa, A, Carlisle, H, Badawi, N, Loughran-Fowlds, A, Koh, G, Davis, J, Luig, M, Andersen, C, Chambers, G, Austin, N, Lynn, A, Darlow, B, Edmonds, L, Mildenhall, L, Buksh, M, Battin, M, Van den Boom, J, Bourchier, D, Richardson, V, Dineen, F, Rajadurai, VS, Fung, G, Harrison, A, Synnes, A, Ting, J, Cieslak, Z, Sherlock, R, Yee, W, Aziz, K, Toye, J, Fajardo, C, Kalapesi, Z, Sankaran, K, Daspal, S, Seshia, M, Alvaro, R, Mukerji, A, Da Silva, O, Nwaesei, C, Lee, K-S, Dunn, M, Lemyre, B, Dow, K, Pelausa, E, Barrington, K, Drolet, C, Piedboeuf, B, Claveau, M, Beltempo, M, Bertelle, V, Masse, E, Canning, R, Mabry, H, Ojah, C, Monterrosa, L, Deshpandey, A, Afifi, J, Kajetanowicz, A, Andersson, S, Tammela, O, Sankilampi, U, Saarela, T, Prazad, P, Noguchi, A, McWan, K, Button, B, Stratton, W, Hamvus, A, Raghaven, A, Derrick, M, Hadley, R, Covert, R, Lablanc, O, Weiss, M, Bell, A, Shareef, M, Silvestri, J, Heymann, E, Zangen, S, Smolkin, T, Mimouni, F, Bader, D, Rothschild, A, Strauss, Z, Felszer, C, Oman, H, Toy-Friedman, SE, Bar-Oz, B, Feldman, M, Saad, N, Flidel-Rimon, O, Weisbrod, M, Lubin, D, Litmanovitz, I, Kngelman, A, Shinwell, E, Klinger, G, Nijim, Y, Bin-Nun, A, Golan, A, Mandel, D, Fleisher-Sheffer, V, Kohelet, D, Bakhrakh, L, Hattori, S, Shirai, M, Ishioka, T, Mori, T, Amiznka, T, Huchimukai, T, Yoshida, H, Sasaki, A, Shimizu, J, Nakamura, T, Maruyama, M, Matsumoto, H, Hosokawa, S, Taki, A, Nakagawa, M, Ko, K, Uozumi, A, Nakata, S, Shimazaki, A, Yoda, T, Numata, O, Imamura, H, Kobayashi, A, Tokuriki, S, Uchida, Y, Arai, T, Ito, M, Ieda, K, Ono, T, Hayashi, M, Maki, K, Yamakawa, M, Kawai, M, Fujii, N, Shiomi, K, Nozaki, K, Wada, H, Kim, T, Tokunaga, Y, Takatera, A, Oshima, T, Sumida, H, Michinomae, Y, Knsumoto, Y, Yoshimoto, S, Morisawa, T, Ohashi, T, Takahashi, Y, Sugimoto, M, Ono, N, Miyagawa, S, Saijo, T, Yamagami, T, Koyano, K, Kobayashi, S, Kanda, T, Sakemi, Y, Aoki, M, Iida, K, Goshi, M, Maruyama, Y, Avila-Alvarez, A, Luis Fernandez-Trisac, J, Couce Pico, ML, Fernandez Seara, MJ, Martinez Gutierrez, A, Vizcaino, C, Salvador Iglesias, M, Sanchez Zaplana, H, Fernandez Colomer, B, Garcia Lopez, JE, Garcia Mozo, R, Gonzalez Martinez, MT, Muro Sebastian, MD, Balart Carbonell, M, Badia Bamnsell, J, Domingo Puiggros, M, Figueras Aloy, J, Botet Mussons, F, Anquela Sanz, I, Ginovart Galiana, G, Coroleu, W, Iriondo, M, Vilella, LC, Porta, R, Demestre, X, Martinez Nadal, S, De Frutos Martinez, C, Lopez Cuesta, MJ, Esquivel Mora, D, Ortiz Tardio, J, Benavente, I, Alonso, A, Aguilera Olmos, R, Garcia Cabezas, MA, Martinez Jimenez, MD, Jaraba Caballero, MF, Ordofiez Diaz, MD, Fagundo, AT, Canals, LM, Garcia-Munoz Rodrigo, F, Urquia Marti, L, Moreno Galdo, MF, Hurtado Suazo, JA, Narbona Lopez, E, Uberos Fernandez, J, Cortajarena Altana, MA, Mora Navarro, D, Teresa Dominguez, M, Ruiz del Prado, MY, Esteban Diez, I, Palau Benavides, MT, Lapena, S, Prada, T, Soler Mir, E, Corredera Sanchez, A, Criado Vega, E, Del Prado, N, Fernandez, C, Cabanillas Vilaplana, L, Cuadrado Perez, I, Lopez Gomez, L, Domingo Comeche, L, Llana Martin, I, Gonzalez Armengod, C, Munoz Labian, C, Santos Munoz, MJ, Blanco Bravo, D, Perez, V, Elorza Fernandez, MD, Diaz Gonzalez, C, Ares Segura, S, Lopez Azorin, M, Belen Jimenez, A, Sanchez-Tamayo, T, Tapia Moreno, E, Gonzalez, M, Sanchez Martinez, JE, Lloreda Garcia, JM, Goni Orayen, C, Vilas Gonzalez, J, Suarez Albo, M, Gonzalez Colmenero, E, Gutierrez Gonzalez, EP, Vacas del Arco, B, Marquez Fernandez, J, Acosta Gordillo, L, Granero Asensio, M, Macias Diaz, C, Albujar, M, Fuster Jorge, P, Romero, S, Rivero Falero, M, Escobar Izquierdo, AB, Estan Capell, J, Izquierdo Macian, MI, Montejo Vicente, MM, Izquierdo Caballero, R, Mercedes Martinez, M, Euba, A, Rodriguez Serna, A, De Heredia Goya, JML, Perez Legorburu, A, Gutierrez Amoros, A, Marugan Isabel, VM, Hernandez Gonzalez, N, Rite Gracia, S, Ventura Faci, MP, Samper Villagrasa, MP, Kofron, J, Brodd, KS, Odlind, A, Alberg, L, Arwehed, S, Hafstrom, O, Kasemo, A, Nederman, K, Ahman, L, Ingemarsson, F, Petersson, H, Thum, P, Albinsson, E, Selander, B, Abrahamsson, T, Heimdahl, I, Sveinsdottir, K, Wejryd, E, Hedlund, A, Soderberg, MK, Hallberg, B, Brune, T, Backstrom, J, Robinson, J, Farooqi, A, Normann, E, Fredriksson, M, Palm, A, Rosenqvist, U, Hagman, C, Ohlin, A, Floral, R, Smedsaas-Lofvenberg, A, Meyer, P, Anderegg, C, Schulzke, S, Nelle, M, Wagner, B, Riedel, T, Kaczala, G, Walde, B, Pfister, RE, Tolsa, J-F, Roth, M, Stocker, M, Laubscher, B, Malzacher, A, Micallef, JP, Hegi, L, Arlettaz, R, Bernet, V, Dani, C, Fiorini, P, Boldrini, A, Tomasini, B, Mittal, A, Kefas, J, Kamalanathan, A, Jayachandran, Yoxall, B, McBride, T, Webb, D, Garr, R, Hassan, A, Ambadkar, P, Dyke, M, McDevitt, K, Rewitzky, G, D'Amore, A, Panasa, N, Settle, P, Maddock, N, Edi-Osagie, N, Zipitis, C, Heal, C, Birch, J, Hasib, A, Soe, A, Kumar, N, Kisat, H, Vasu, V, Lama, M, Gupta, R, Rawlingson, C, Wickham, T, Theron, M, Kendall, G, Gupta, A, Aladangady, N, Ali, I, Alsford, L, Lopez, W, Murthy, V, Sullivan, C, Thomas, M, Bate, T, Godambe, S, Watts, T, Kuna, J, Chang, J, Pai, V, Huddy, C, Yasin, S, Nicholl, R, Pandey, P, Kairamkonda, V, Muogbo, D, Harry, L, Simmons, P, Nycyk, J, Gallagher, A, Pillay, T, Deshpande, S, Mahadevan, Moore, A, Clark, S, Garbash, M, Lal, M, Abu-Harb, M, Allwood, A, Selter, M, Munyard, P, Bartle, D, Paul, S, Whincup, G, Mallik, A, Amess, P, Godden, C, Reynolds, P, Misra, I, De Halpert, P, Salgia, S, Sanghavi, R, Wigfield, R, Deketelaere, A, Khashu, M, Hall, M, Groves, C, Brown, N, Brennan, N, Vamvakiti, K, McIntyre, J, Pirie, S, Jones, S, Mannix, P, Cairns, P, Eaton, M, Schwarz, K, Gibson, D, Miall, L, Krishnamurthy, University of Zurich, Shah, Prakesh S, Canadian Institutes of Health Research (CIHR), and Neonid NPO

Subjects
medicine.medical_specialty, NEW-ZEALAND, Population, 610 Medicine & health, RETINOPATHY, Review Article, Audit, Pediatrics, outcomes research, MORBIDITY, Nursing, neonatal intensive care, Health care, medicine, LOW-BIRTH-WEIGHT, 2735 Pediatrics, Perinatology and Child Health, education, education.field_of_study, Science & Technology, EXTREMELY PRETERM INFANTS, business.industry, MORTALITY, Public health, Health services research, Preterm infants, Capacity building, BRONCHOPULMONARY DYSPLASIA, Benchmarking, 10027 Clinic for Neonatology, INTENSIVE-CARE UNITS, TRENDS, CANADA, Pediatrics, Perinatology and Child Health, Outcomes research, business, Life Sciences & Biomedicine
Abstract

Neonates born very preterm (before 32 weeks’ gestational age), are a significant public health concern because of their high-risk of mortality and life-long disability. In addition, caring for very preterm neonates can be expensive, both during their initial hospitalization and their long-term cost of permanent impairments. To address these issues, national and regional neonatal networks around the world collect and analyse data from their constituents to identify trends in outcomes, and conduct benchmarking, audit and research. Improving neonatal outcomes and reducing health care costs is a global problem that can be addressed using collaborative approaches to assess practice variation between countries, conduct research and implement evidence-based practices. The International Network for Evaluating Outcomes (iNeo) of neonates was established in 2013 with the goal of improving outcomes for very preterm neonates through international collaboration and comparisons. To date, 10 national or regional population-based neonatal networks/datasets participate in iNeo collaboration. The initiative now includes data on >200,000 very preterm neonates and has conducted important epidemiological studies evaluating outcomes, variations and trends. The collaboration has also surveyed >320 neonatal units worldwide to learn about variations in practices, healthcare service delivery, and physical, environmental and manpower related factors and support services for parents. The iNeo collaboration serves as a strong international platform for Neonatal-Perinatal health services research that facilitates international data sharing, capacity building, and global efforts to improve very preterm neonate care.

Published
2019

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