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2 results on '"Butorano Magm"'

1. Angiosarcomatoid Dermo-Hypodermic Lung and Cardiac Metastases from Malignant Breast Phyllodes Tumour

Author

Tacchini D, Ferrara F, Butorano Magm, Di Bella G, and Voglino C

Subjects
Pathology, medicine.medical_specialty, Lung, Diagnostic methods, business.industry, Breast tumor, medicine.anatomical_structure, Phyllodes tumours, medicine, Thoracic ct, Angiosarcoma, Differential diagnosis, Cutaneous metastasis, business
Abstract

Introduction: Phyllodes tumours are rare neoplasms, representing less than 1% of all primary tumours of the breast. Case report: We report the case of a woman who presented with a malignant phyllodes tumour of the breast, with an osteosarcomatous component. A year after surgery, a control thoracic CT scan revealed nodules in the lung. Shortly after, she also developed cardiac and dermo-hypodermic lesions, histologically characterized as angiosarcoma with an osteoclastic component. Discussion: Malignant breast phyllodes tumour often metastasizes to the lungs, bones, liver and brain. To the best of our knowledge, there is only one case in literature that reports a cutaneous metastasis of phyllodes tumour under the form of an angiosarcoma, whilst, to date, no such myocardial involvement has been reported.

Published
2016
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2. High-mobility group box protein 1 expression in inflammatory diseases of the middle ear.

Author

Bellussi LM, Vindigni C, Cocca S, Butorano MAGM, Livi W, Corallo G, and Passali D

Subjects
Adolescent, Adult, Aged, Ear, Middle metabolism, Ear, Middle pathology, Female, Humans, Male, Middle Aged, Mucous Membrane metabolism, Mucous Membrane pathology, Otitis Media pathology, Young Adult, HMGB1 Protein metabolism, Otitis Media metabolism
Abstract

High-mobility group box 1 (HMGB1) is a nuclear non-histone protein, playing a critical role as a mediator between innate and acquired immunity; when released extracellularly, it coordinates the cellular stress response (under necrosis, bacterial lipopolysaccharide stimulation) and acts as an inflammatory marker and cytokine. The aim of the study was to demonstrate whether HMGB1 is over-expressed in chronic middle-ear pathologies and whether the entity of expression and the localization are correlated with the degree of the inflammatory reaction, thus suggesting that HMGB1 may play a crucial role in chronic inflammatory disorders of the middle ear, as already demonstrated in other airway diseases. We analyzed 30 samples of middle-ear mucosa in patients affected by chronic suppurative otitis media with ear drum perforation with/without cholesteatoma and otosclerosis as control. The distribution of HMGB1 was evaluated as nuclear, cytoplasmic, and/or extracellular staining. The inflammatory cells observed in the biopsies were mostly lymphocytes and plasmacells. A statistically significant difference in inflammation score between otosclerosis and chronic otitis samples ( P < 0.01; Anova test) and between otosclerosis and cholesteatoma samples ( P < 0.05; Anova test) was observed; the HMGB1 positivity was in accordance with the density of the inflammatory infiltrate. HMGB1 is over-expressed in chronic middle-ear pathologies and may play a role in the progression of the inflammatory process from recurrent acute otitis media to chronic suppurative otitis media.

Published
2017
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