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6. Indwelling central venous catheter infection with Chryseobacterium shandongense - successful eradication in a 5-year-old with cystic fibrosis.

Author

Rowan A, Verbruggen TF, O'Connell NH, Stapleton PJ, Dunne CP, Linnane B, and Butler D

Abstract

Introduction: Chryseobacterium shandongense is a Gram-negative Flavobacterium bacillus with intrinsic multidrug-resistant properties., Case Presentation: Herein, we present the first case report of human C. shandongense infection, relating to an implantable portal and catheter (port-a-cath) central line in a 5-year-old female with cystic fibrosis. The infection was identified using a Bruker MALDI-TOF Biotyper with BDAL (v12) of blood, which was cultured due to pyrexia and rigour following port-a-cath access. This report details the effective eradication of C. shandongense infection from the port-a-cath device using initial empirical gentamicin followed by targeted ciprofloxacin locks and systemic antibiotics., Conclusion: We demonstrated successful eradication of C. shandongense from a port-a-cath device, including the minimum inhibitory concentrations (MICs) required in this case. The result was eradication of central access infection, preventing progression to bacteraemia/septicaemia and preserving central access in a child with cystic fibrosis and established respiratory disease., Competing Interests: The authors declare that there are no conflicts of interest., (© 2023 The Authors.)

Published
2023
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7. Skin Punctures in Preterm Infants in the First 2 Weeks of Life.

Author

Finn D, Butler D, Sheehan O, Livingstone V, and Dempsey EM

Subjects
Female, Humans, Infant, Newborn, Ireland, Male, Medical Audit statistics & numerical data, Risk Assessment, Gestational Age, Infant, Premature, Intensive Care Units, Neonatal standards, Intensive Care Units, Neonatal statistics & numerical data, Punctures adverse effects, Punctures methods, Punctures statistics & numerical data, Sepsis epidemiology
Abstract

Objective: The objective of this study was to investigate frequency and trends of skin punctures in preterm infants., Study Design: A prospective audit of preterm infants less than 35 weeks admitted over a 6-month period to a tertiary neonatal intensive care unit. Each skin puncture performed in the first 2 weeks of life was documented in a specifically designed audit sheet., Results: Ninety-nine preterm infants were enrolled. Infants born at < 32 weeks' gestation had significantly more skin punctures than infants > 32 weeks (median skin punctures 26.5 vs. 17, p -value < 0.05). The highest frequency of skin punctures occurred during the first week of life for infants > 28 weeks' gestation (medians 17.5 in 28-31 + 6 weeks' gestation, and 15 in > 32 weeks), and during the second week of life for those born at < 28 weeks (median 17.5). Infants with sepsis had more skin punctures ( p -value < 0.001), but this was not significant on multivariate analysis. Median skin punctures in the second week of life were statistically higher in the sepsis group on multivariate analysis (odds ratio: 1.07, 95% confidence interval: 1.00-1.14, p  = 0.041)., Conclusion: Frequency of skin punctures is influenced by gestational age and postnatal age. Skin punctures were not an independent risk factor for sepsis., Competing Interests: None., (Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.)

Published
2018
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