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6 results on '"Bustamante Mandrión, José"'

1. Prospective validation of prognostic and diagnostic syncope scores in the emergency department

Author

du Fay de Lavallaz, Jeanne, Badertscher, Patrick, Nestelberger, Thomas, Isenrich, Rahel, Miró, Òscar, Salgado, Emilio, Geigy, Nicolas, Christ, Michael, Cullen, Louise, Than, Martin, Martin-Sanchez, F. Javier, Bustamante Mandrión, José, Di Somma, Salvatore, Peacock, W. Frank, Kawecki, Damian, Boeddinghaus, Jasper, Twerenbold, Raphael, Puelacher, Christian, Wussler, Desiree, Strebel, Ivo, Keller, Dagmar I., Poepping, Imke, Kühne, Michael, Mueller, Christian, Reichlin, Tobias, Giménez, Maria Rubini, Walter, Joan, Kozhuharov, Nikola, Shrestha, Samyut, Mueller, Deborah, Sazgary, Lorraine, Morawiec, Beata, Muzyk, Piotr, Nowalany-Kozielska, Ewa, Freese, Michael, Stelzig, Claudia, Meissner, Kathrin, Kulangara, Caroline, Hartmann, Beate, Ferel, Ina, Sabti, Zaid, Greenslade, Jaimi, Hawkins, Tracey, Rentsch, Katharina, von Eckardstein, Arnold, Buser, Andreas, Kloos, Wanda, Lohrmann, Jens, and Osswald, Stefan

Published
2018
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2. Early standardized clinical judgement for syncope diagnosis in the emergency department

Author

du Fay de Lavallaz, J., Badertscher, P., Zimmermann, T., Nestelberger, T., Walter, J., Strebel, I., Coelho, C., Miró, Salgado, E., Christ, M., Geigy, N., Cullen, L., Than, M., Javier Martin-Sanchez, F., Di Somma, S., Frank Peacock, W., Morawiec, B., Wussler, D., Keller, D. I., Gualandro, D., Michou, E., Kühne, M., Lohrmann, J., Reichlin, T., Mueller, C., Flores, Dayana, Widmer, Velina, Breidthardt, Tobias, Bustamante Mandrión, José, Poepping, Imke, Kawecki, Damian, Muzyk, Piotr, Belkin, Maria, Puelacher, Christian, Lopez Ayala, Pedro, Freese, Michael, Boeddinghaus, Jasper, Diebold, Matthias, Koechlin, Luca, Greenslade, Jaimi, Hawkins, Tracey, Rentsch, Katharina, von Eckardstein, Arnold, Buser, Andreas, Campodarve, Isabel, Gea, Joachim, Cruz, Helena Mañé, Calderon, Sofìa, Fuenzalida Inostroza, Carolina Isabel, Briñón, Miguel Angel García, Suárez Cadenas, María, Bingisser, Roland, Osswald, Stefan, other, and, du Fay de Lavallaz, J., Badertscher, P., Zimmermann, T., Nestelberger, T., Walter, J., Strebel, I., Coelho, C., Miró, Salgado, E., Christ, M., Geigy, N., Cullen, L., Than, M., Javier Martin-Sanchez, F., Di Somma, S., Frank Peacock, W., Morawiec, B., Wussler, D., Keller, D. I., Gualandro, D., Michou, E., Kühne, M., Lohrmann, J., Reichlin, T., Mueller, C., Flores, Dayana, Widmer, Velina, Breidthardt, Tobias, Bustamante Mandrión, José, Poepping, Imke, Kawecki, Damian, Muzyk, Piotr, Belkin, Maria, Puelacher, Christian, Lopez Ayala, Pedro, Freese, Michael, Boeddinghaus, Jasper, Diebold, Matthias, Koechlin, Luca, Greenslade, Jaimi, Hawkins, Tracey, Rentsch, Katharina, von Eckardstein, Arnold, Buser, Andreas, Campodarve, Isabel, Gea, Joachim, Cruz, Helena Mañé, Calderon, Sofìa, Fuenzalida Inostroza, Carolina Isabel, Briñón, Miguel Angel García, Suárez Cadenas, María, Bingisser, Roland, Osswald, Stefan, and other, and

Abstract

Background: The diagnosis of cardiac syncope remains a challenge in the emergency department (ED). Objective: Assessing the diagnostic accuracy of the early standardized clinical judgement (ESCJ) including a standardized syncope-specific case report form (CRF) in comparison with a recommended multivariable diagnostic score. Methods: In a prospective international observational multicentre study, diagnostic accuracy for cardiac syncope of ESCJ by the ED physician amongst patients ≥ 40 years presenting with syncope to the ED was directly compared with that of the Evaluation of Guidelines in Syncope Study (EGSYS) diagnostic score. Cardiac syncope was centrally adjudicated independently of the ESCJ or conducted workup by two ED specialists based on all information available up to 1-year follow-up. Secondary aims included direct comparison with high-sensitivity cardiac troponin I (hs-cTnI) and B-type natriuretic peptide (BNP) concentrations and a Lasso regression to identify variables contributing most to ESCJ. Results: Cardiac syncope was adjudicated in 252/1494 patients (15.2%). The diagnostic accuracy of ESCJ for cardiac syncope as quantified by the area under the curve (AUC) was 0.87 (95% CI: 0.84–0.89), and higher compared with the EGSYS diagnostic score (0.73 (95% CI: 0.70–0.76)), hs-cTnI (0.77 (95% CI: 0.73–0.80)) and BNP (0.77 (95% CI: 0.74–0.80)), all P < 0.001. Both biomarkers (alone or in combination) on top of the ESCJ significantly improved diagnostic accuracy. Conclusion: ESCJ including a standardized syncope-specific CRF has very high diagnostic accuracy and outperforms the EGSYS score, hs-cTnI and BNP.

Published
2021

3. Prevalence of Pulmonary Embolism in Patients With Syncope

Author

Badertscher, Patrick, primary, du Fay de Lavallaz, Jeanne, additional, Hammerer-Lercher, Angelika, additional, Nestelberger, Thomas, additional, Zimmermann, Tobias, additional, Geiger, Marc, additional, Imahorn, Orell, additional, Miró, Òscar, additional, Salgado, Emilio, additional, Christ, Michael, additional, Cullen, Louise, additional, Than, Martin, additional, Martin-Sanchez, F. Javier, additional, Di Somma, Salvatore, additional, Peacock, W. Frank, additional, Keller, Dagmar I., additional, Costabel, Juan Pablo, additional, Walter, Joan, additional, Boeddinghaus, Jasper, additional, Twerenbold, Raphael, additional, Méndez, Adriana, additional, Gospodinov, Boris, additional, Puelacher, Christian, additional, Wussler, Desiree, additional, Koechlin, Luca, additional, Kawecki, Damian, additional, Geigy, Nicolas, additional, Strebel, Ivo, additional, Lohrmann, Jens, additional, Kühne, Michael, additional, Reichlin, Tobias, additional, Mueller, Christian, additional, Rubini Giménez, Maria, additional, Kozhuharov, Nikola, additional, Shrestha, Samyut, additional, Sazgary, Lorraine, additional, Morawiec, Beata, additional, Muzyk, Piotr, additional, Nowalany-Kozielska, Ewa, additional, Bustamante Mandrión, José, additional, Poepping, Imke, additional, Freese, Michael, additional, Meissner, Kathrin, additional, Kulangara, Caroline, additional, Fuenzalida Inostroza, Carolina Isabel, additional, Greenslade, Jaimi, additional, Hawkins, Tracey, additional, Rentsch, Katharina, additional, von Eckardstein, Arnold, additional, Buser, Andreas, additional, Kloos, Wanda, additional, Steude, Jana, additional, and Osswald, Stefan, additional

Published
2019
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4. Prevalence of pulmonary embolism in patients with syncope

Author

Badertscher, Patrick, du Fay de Lavallaz, Jeanne, Hammerer-Lercher, Angelika, Nestelberger, Thomas, Zimmermann, Tobias, Geiger, Marc, Imahorn, O., Miró, Òscar, Salgado, Emilio, Christ, Michael, Cullen, Louise, Than, Martin, Martin-Sanchez, F. Javier, Di Somma, Salvatore, Peacock, W. Frank, Keller, Dagmar I., Costabel, Juan Pablo, Walter, Joan, Boeddinghaus, Jasper, Twerenbold, Raphael, Méndez, Adriana, Gospodinov, B., Puelacher, Christian, Wussler, Desiree, Koechlin, Luca, Kawecki, Damian, Geigy, Nicolas, Strebel, Ivo, Lohrmann, Jens, Kühne, Michael, Reichlin, Tobias, Mueller, Christian, Rubini Giménez, M., Kozhuharov, Nikola, Shrestha, Samyut, Sazgary, Lorraine, Morawiec, B., Muzyk, P., Nowalany-Kozielska, Ewa, Bustamante Mandrión, José, Poepping, Imke, Freese, Michael, Meissner, Kathrin, Kulangara, Caroline, Fuenzalida Inostroza, Carolina Isabel, Greenslade, Jaimi, Hawkins, Tracey, Rentsch, Katharina, von Eckardstein, Arnold, Buser, Andreas, Kloos, W., Steude, Jana, Osswald, Stefan, Badertscher, Patrick, du Fay de Lavallaz, Jeanne, Hammerer-Lercher, Angelika, Nestelberger, Thomas, Zimmermann, Tobias, Geiger, Marc, Imahorn, O., Miró, Òscar, Salgado, Emilio, Christ, Michael, Cullen, Louise, Than, Martin, Martin-Sanchez, F. Javier, Di Somma, Salvatore, Peacock, W. Frank, Keller, Dagmar I., Costabel, Juan Pablo, Walter, Joan, Boeddinghaus, Jasper, Twerenbold, Raphael, Méndez, Adriana, Gospodinov, B., Puelacher, Christian, Wussler, Desiree, Koechlin, Luca, Kawecki, Damian, Geigy, Nicolas, Strebel, Ivo, Lohrmann, Jens, Kühne, Michael, Reichlin, Tobias, Mueller, Christian, Rubini Giménez, M., Kozhuharov, Nikola, Shrestha, Samyut, Sazgary, Lorraine, Morawiec, B., Muzyk, P., Nowalany-Kozielska, Ewa, Bustamante Mandrión, José, Poepping, Imke, Freese, Michael, Meissner, Kathrin, Kulangara, Caroline, Fuenzalida Inostroza, Carolina Isabel, Greenslade, Jaimi, Hawkins, Tracey, Rentsch, Katharina, von Eckardstein, Arnold, Buser, Andreas, Kloos, W., Steude, Jana, and Osswald, Stefan

Abstract

Background: The prevalence of pulmonary embolism (PE) in patients presenting with syncope to the emergency department (ED) is largely unknown. This information, however, is necessary to balance the potential medical benefit or harm of systematic PE screening in patients presenting with syncope to the ED. Objectives: This study sought to determine the prevalence of PE in patients with syncope. Methods: Unselected patients presenting with syncope to the ED were prospectively enrolled in a diagnostic multicenter study. Pre-test clinical probability for PE was assessed using the 2-level Wells score and the results of D-dimer testing using age-adapted cutoffs. Presence of PE was evaluated by imaging modalities, when ordered as part of the clinical assessment by the treating ED physician or by long-term follow-up data. Results: Long-term follow-up was complete in 1,380 patients (99%) at 360 days and 1,156 patients (83%) at 720 days. Among 1,397 patients presenting with syncope to the ED, PE was detected at presentation in 19 patients (1.4%; 95% confidence interval [CI]: 0.87% to 2.11%). The incidence of new PEs or cardiovascular death during 2-year follow-up was 0.9% (95% CI: 0.5% to 1.5%). In the subgroup of patients hospitalized (47%), PE was detected at presentation in 15 patients (2.3%; 95% CI: 1.4% to 3.7%). The incidence of new PEs or cardiovascular death during 2-year follow-up was 0.9% (95% CI: 0.4% to 2.0%). Conclusions: PE seems to be a rather uncommon cause of syncope among patients presenting to the ED. Therefore, systematic PE-screening in all patients with syncope does not seem warranted. (BAsel Syncope EvaLuation Study [BASEL IX]; NCT01548352)

Published
2019

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