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2. Home and school pollutant exposure, respiratory outcomes, and influence of historical redlining

Author

Jung, Kyung Hwa, Argenio, Kira L., Jackson, Daniel J., Miller, Rachel L., Perzanowski, Matthew S., Rundle, Andrew G., Bacharier, Leonard B., Busse, William W., Cohen, Robyn T., Visness, Cynthia M., Gill, Michelle A., Gruchalla, Rebecca S., Hershey, Gurjit K., Kado, Rachel K., Sherenian, Michael G., Liu, Andrew H., Makhija, Melanie M., Pillai, Dinesh K., Rivera-Spoljaric, Katherine, Gergen, Peter J., Altman, Matthew C., Sandel, Megan T., Sorkness, Christine A., Kattan, Meyer, and Lovinsky-Desir, Stephanie

Published
2024
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3. A pediatric randomized, controlled trial of German cockroach subcutaneous immunotherapy

Author

Zoratti, Edward, Wood, Robert, Pomés, Anna, Da Silva Antunes, Ricardo, Altman, Matthew C., Benson, Basilin, Wheatley, Lisa M., Cho, Kate, Calatroni, Agustin, Little, Frederic F., Pongracic, J., Makhija, Melanie, Khurana Hershey, Gurjit K., Sherenian, Michael G., Rivera-Spoljaric, Katherine, Stokes, Jeffrey R., Gill, Michelle A., Gruchalla, Rebecca S., Chambliss, Jeffrey, Liu, Andrew H., Kattan, Meyer, Busse, Paula J., Bacharier, Leonard B., Sheehan, William, Kim, Haejin., Glesner, Jill, Gergen, Peter J., Togias, Alkis, Baucom, Jessica L., Visness, Cynthia M., Sette, Alessandro, Busse, William W., and Jackson, Daniel J.

Published
2024
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5. Activated sputum eosinophils associated with exacerbations in children on mepolizumab

Author

Wilson, Gabriella E., Knight, James, Liu, Qing, Shelar, Ashish, Stewart, Emma, Wang, Xiaomei, Yan, Xiting, Sanders, Joshua, Visness, Cynthia, Gill, Michelle, Gruchalla, Rebecca, Liu, Andrew H., Kattan, Meyer, Khurana Hershey, Gurjit K., Togias, Alkis, Becker, Patrice M., Altman, Matthew C., Busse, William W., Jackson, Daniel J., Montgomery, Ruth R., and Chupp, Geoffrey L.

Published
2024
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8. Gene-based association study of rare variants in children of diverse ancestries implicates TNFRSF21 in the development of allergic asthma

Author

Clay, Selene, Alladina, Jehan, Smith, Neal P., Visness, Cynthia M., Wood, Robert A., O’Connor, George T., Cohen, Robyn T., Khurana Hershey, Gurjit K., Kercsmar, Carolyn M., Gruchalla, Rebecca S., Gill, Michelle A., Liu, Andrew H., Kim, Haejin, Kattan, Meyer, Bacharier, Leonard B., Rastogi, Deepa, Rivera-Spoljaric, Katherine, Robison, Rachel G., Gergen, Peter J., Busse, William W., Villani, Alexandra-Chloe, Cho, Josalyn L., Medoff, Benjamin D., Gern, James E., Jackson, Daniel J., Ober, Carole, and Dapas, Matthew

Published
2024
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13. Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways

Author

Li, Xingnan, Christenson, Stephanie A, Modena, Brian, Li, Huashi, Busse, William W, Castro, Mario, Denlinger, Loren C, Erzurum, Serpil C, Fahy, John V, Gaston, Benjamin, Hastie, Annette T, Israel, Elliot, Jarjour, Nizar N, Levy, Bruce D, Moore, Wendy C, Woodruff, Prescott G, Kaminski, Naftali, Wenzel, Sally E, Bleecker, Eugene R, Meyers, Deborah A, and Program, NHLBI Severe Asthma Research

Subjects
Biomedical and Clinical Sciences, Immunology, Biotechnology, Genetics, Lung, Human Genome, Asthma, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Respiratory, Adult, Chromosomes, Human, Pair 17, Disease Progression, Genetic Association Studies, Genotype, Humans, Middle Aged, Neoplasm Proteins, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Respiratory Mucosa, Sequence Analysis, RNA, Severity of Illness Index, Whole Genome Sequencing, Antiviral pathways, asthma exacerbations, asthma severity, eQTL, genetics, GSDMA, GSDMB, PGAP3, whole-genome sequence, RNAseq, NHLBI Severe Asthma Research Program, Allergy
Abstract

BackgroundThe Chr17q12-21.2 region is the strongest and most consistently associated region with asthma susceptibility. The functional genes or single nucleotide polymorphisms (SNPs) are not obvious due to linkage disequilibrium.ObjectivesWe sought to comprehensively investigate whole-genome sequence and RNA sequence from human bronchial epithelial cells to dissect functional genes/SNPs for asthma severity in the Severe Asthma Research Program.MethodsExpression quantitative trait loci analysis (n = 114), correlation analysis (n = 156) of gene expression and asthma phenotypes, and pathway analysis were performed in bronchial epithelial cells and replicated. Genetic association for asthma severity (426 severe vs 531 nonsevere asthma) and longitudinal asthma exacerbations (n = 273) was performed.ResultsMultiple SNPs in gasdermin B (GSDMB) associated with asthma severity (odds ratio, >1.25) and longitudinal asthma exacerbations (P < .05). Expression quantitative trait loci analyses identified multiple SNPs associated with expression levels of post-GPI attachment to proteins 3, GSDMB, or gasdermin A (3.1 × 10-9 -4). Higher expression levels of GSDMB correlated with asthma and greater number of exacerbations (P < .05). Expression levels of GSDMB correlated with genes involved in IFN signaling, MHC class I antigen presentation, and immune system pathways (false-discovery rate-adjusted P < .05). rs1031458 and rs3902920 in GSDMB colocalized with IFN regulatory factor binding sites and associated with GSDMB expression, asthma severity, and asthma exacerbations (P < .05).ConclusionsBy using a unique set of gene expression data from lung cells obtained using bronchoscopy from comprehensively characterized subjects with asthma, we show that SNPs in GSDMB associated with asthma severity, exacerbations, and GSDMB expression levels. Furthermore, its expression levels correlated with asthma exacerbations and antiviral pathways. Thus, GSDMB is a functional gene for both asthma susceptibility and severity.

Published
2021

17. HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma

Author

Zein, Joe, Gaston, Benjamin, Bazeley, Peter, DeBoer, Mark D, Igo, Robert P, Bleecker, Eugene R, Meyers, Deborah, Comhair, Suzy, Marozkina, Nadzeya V, Cotton, Calvin, Patel, Mona, Alyamani, Mohammad, Xu, Weiling, Busse, William W, Calhoun, William J, Ortega, Victor, Hawkins, Gregory A, Castro, Mario, Chung, Kian Fan, Fahy, John V, Fitzpatrick, Anne M, Israel, Elliot, Jarjour, Nizar N, Levy, Bruce, Mauger, David T, Moore, Wendy C, Noel, Patricia, Peters, Stephen P, Teague, W Gerald, Wenzel, Sally E, Erzurum, Serpil C, and Sharifi, Nima

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Clinical Sciences, Lung, Asthma, Genetics, Adult, Aged, Alleles, Androgens, Cohort Studies, Drug Resistance, Female, Genotype, Glucocorticoids, Humans, Male, Middle Aged, Multienzyme Complexes, Progesterone Reductase, Steroid Isomerases, Young Adult, steroids, glucocorticoids, inflammation, androgens, HSD3B1
Abstract

Asthma resistance to glucocorticoid treatment is a major health problem with unclear etiology. Glucocorticoids inhibit adrenal androgen production. However, androgens have potential benefits in asthma. HSD3B1 encodes for 3β-hydroxysteroid dehydrogenase-1 (3β-HSD1), which catalyzes peripheral conversion from adrenal dehydroepiandrosterone (DHEA) to potent androgens and has a germline missense-encoding polymorphism. The adrenal restrictive HSD3B1(1245A) allele limits conversion, whereas the adrenal permissive HSD3B1(1245C) allele increases DHEA metabolism to potent androgens. In the Severe Asthma Research Program (SARP) III cohort, we determined the association between DHEA-sulfate and percentage predicted forced expiratory volume in 1 s (FEV1PP). HSD3B1(1245) genotypes were assessed, and association between adrenal restrictive and adrenal permissive alleles and FEV1PP in patients with (GC) and without (noGC) daily oral glucocorticoid treatment was determined (n = 318). Validation was performed in a second cohort (SARP I&II; n = 184). DHEA-sulfate is associated with FEV1PP and is suppressed with GC treatment. GC patients homozygous for the adrenal restrictive genotype have lower FEV1PP compared with noGC patients (54.3% vs. 75.1%; P < 0.001). In patients with the homozygous adrenal permissive genotype, there was no FEV1PP difference in GC vs. noGC patients (73.4% vs. 78.9%; P = 0.39). Results were independently confirmed: FEV1PP for homozygous adrenal restrictive genotype in GC vs. noGC is 49.8 vs. 63.4 (P < 0.001), and for homozygous adrenal permissive genotype, it is 66.7 vs. 67.7 (P = 0.92). The adrenal restrictive HSD3B1(1245) genotype is associated with GC resistance. This effect appears to be driven by GC suppression of 3β-HSD1 substrate. Our results suggest opportunities for prediction of GC resistance and pharmacologic intervention.

Published
2020

18. Investigation of the relationship between IL-6 and type 2 biomarkers in patients with severe asthma

Author

Li, Xingnan, Hastie, Annette T, Peters, Michael C, Hawkins, Gregory A, Phipatanakul, Wanda, Li, Huashi, Moore, Wendy C, Busse, William W, Castro, Mario, Erzurum, Serpil C, Gaston, Benjamin, Israel, Elliot, Jarjour, Nizar N, Levy, Bruce D, Wenzel, Sally E, Meyers, Deborah A, Fahy, John V, Bleecker, Eugene R, and National Heart, Lung

Subjects
Biomedical and Clinical Sciences, Immunology, Adolescent, Adult, Asthma, Biomarkers, Child, Female, Humans, Interleukin-6, Male, Severity of Illness Index, National Heart, Lung, and Blood Institute's Severe Asthma Research Program (SARP) Networks, Allergy
Abstract

Combination of IL-6 (non-Type 2 asthma) and FeNO or blood eosinophil count (Type 2 asthma) identified asthma endotypes related to asthma severity, exacerbations, and responsiveness to corticosteroids and potential for response to anti-Type 2 and anti-IL-6 treatment.

Published
2020

20. Asthma

Author

Eapen, Saju S., primary and Busse, William W., additional

Published
2023
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21. Associations between outdoor air pollutants and non-viral asthma exacerbations and airway inflammatory responses in children and adolescents living in urban areas in the USA: a retrospective secondary analysis

Author

Altman, Matthew C, Kattan, Meyer, O'Connor, George T, Murphy, Ryan C, Whalen, Elizabeth, LeBeau, Petra, Calatroni, Agustin, Gill, Michelle A, Gruchalla, Rebecca S, Liu, Andrew H, Lovinsky-Desir, Stephanie, Pongracic, Jacqueline A, Kercsmar, Carolyn M, Khurana Hershey, Gurjit K, Zoratti, Edward M, Teach, Stephen J, Bacharier, Leonard B, Wheatley, Lisa M, Sigelman, Steve M, Gergen, Peter J, Togias, Alkis, Busse, William W, Gern, James E, and Jackson, Daniel J

Published
2023
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26. Mepolizumab for urban children with exacerbation-prone eosinophilic asthma in the USA (MUPPITS-2): a randomised, double-blind, placebo-controlled, parallel-group trial

Author

Jackson, Daniel J, Bacharier, Leonard B, Gergen, Peter J, Gagalis, Lisa, Calatroni, Agustin, Wellford, Stephanie, Gill, Michelle A, Stokes, Jeffrey, Liu, Andrew H, Gruchalla, Rebecca S, Cohen, Robyn T, Makhija, Melanie, Khurana Hershey, Gurjit K, O'Connor, George T, Pongracic, Jacqueline A, Sherenian, Michael G, Rivera-Spoljaric, Katherine, Zoratti, Edward M, Teach, Stephen J, Kattan, Meyer, Dutmer, Cullen M, Kim, Haejin, Lamm, Carin, Sheehan, William J, Segnitz, R Max, Dill-McFarland, Kimberly A, Visness, Cynthia M, Becker, Patrice M, Gern, James E, Sorkness, Christine A, Busse, William W, and Altman, Matthew C

Published
2022
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28. Therapeutic relevance of eosinophilic inflammation and airway viral interactions in severe asthma.

Author

Rupani, Hitasha, Busse, William W., Howarth, Peter H., Bardin, Philip G., Adcock, Ian M., Konno, Satoshi, and Jackson, David J.

Subjects
*RESPIRATORY infections, *EOSINOPHILS, *ASTHMATICS, *BIOTHERAPY, *VIRUS diseases
Abstract

The role of eosinophils in airway inflammation and asthma pathogenesis is well established, with raised eosinophil counts in blood and sputum associated with increased disease severity and risk of asthma exacerbation. Conversely, there is also preliminary evidence suggesting antiviral properties of eosinophils in the airways. These dual roles for eosinophils are particularly pertinent as respiratory virus infections contribute to asthma exacerbations. Biologic therapies targeting key molecules implicated in eosinophil‐associated pathologies have been approved in patients with severe asthma and, therefore, the effects of depleting eosinophils in a clinical setting are of considerable interest. This review discusses the pathological and antiviral roles of eosinophils in asthma and exacerbations. We also highlight the significant reduction in asthma exacerbations seen with biologic therapies, even at the height of the respiratory virus season. Furthermore, we discuss the implications of these findings in relation to the role of eosinophils in inflammation and antiviral responses to respiratory virus infection in asthma. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Efficacy of dupilumab on clinical outcomes in patients with asthma and perennial allergic rhinitis

Author

Busse, William W., Maspero, Jorge F., Lu, Yufang, Corren, Jonathan, Hanania, Nicola A., Chipps, Bradley E., Katelaris, Constance H., FitzGerald, J. Mark, Quirce, Santiago, Ford, Linda B., Rice, Megan S., Kamat, Siddhesh, Khan, Asif H., Jagerschmidt, Alexandre, Harel, Sivan, Rowe, Paul, Pirozzi, Gianluca, Amin, Nikhil, Ruddy, Marcella, Graham, Neil M.H., and Teper, Ariel

Published
2020
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35. Aeroallergen Sensitization, Serum IgE, and Eosinophilia as Predictors of Response to Omalizumab Therapy During the Fall Season Among Children with Persistent Asthma

Author

Sheehan, William J., Krouse, Rebecca Z., Calatroni, Agustin, Gergen, Peter J., Gern, James E., Gill, Michelle A., Gruchalla, Rebecca S., Khurana Hershey, Gurjit K., Kattan, Meyer, Kercsmar, Carolyn M., Lamm, Carin I., Little, Frederic F., Makhija, Melanie M., Searing, Daniel A., Zoratti, Edward, Busse, William W., and Teach, Stephen J.

Published
2020
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40. Dupilumab Efficacy in Uncontrolled, Moderate-to-Severe Asthma with Self-Reported Chronic Rhinosinusitis

Author

Maspero, Jorge F., Katelaris, Constance H., Busse, William W., Castro, Mario, Corren, Jonathan, Chipps, Bradley E., Peters, Anju T., Pavord, Ian D., Ford, Linda B., Sher, Lawrence, Rabe, Klaus F., Rice, Megan S., Rowe, Paul, Lu, Yufang, Harel, Sivan, Jagerschmidt, Alexandre, Khan, Asif H., Kamat, Siddhesh, Pirozzi, Gianluca, Amin, Nikhil, Ruddy, Marcella, Graham, Neil M.H., Mannent, Leda P., and Teper, Ariel

Published
2020
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44. Report from the National Institute of Allergy and Infectious Diseases workshop on “Atopic dermatitis and the atopic march: Mechanisms and interventions”

Author

Davidson, Wendy F., Leung, Donald Y.M., Beck, Lisa A., Berin, Cecilia M., Boguniewicz, Mark, Busse, William W., Chatila, Talal A., Geha, Raif S., Gern, James E., Guttman-Yassky, Emma, Irvine, Alan D., Kim, Brian S., Kong, Heidi H., Lack, Gideon, Nadeau, Kari C., Schwaninger, Julie, Simpson, Angela, Simpson, Eric L., Spergel, Jonathan M., Togias, Alkis, Wahn, Ulrich, Wood, Robert A., Woodfolk, Judith A., Ziegler, Steven F., and Plaut, Marshall

Published
2019
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45. Rhinitis in children and adolescents with asthma: Ubiquitous, difficult to control, and associated with asthma outcomes

Author

Togias, Alkis, Gergen, Peter J., Hu, Jack W., Babineau, Denise C., Wood, Robert A., Cohen, Robyn T., Makhija, Melanie M., Khurana Hershey, Gurjit K., Kercsmar, Carolyn M., Gruchalla, Rebecca S., Liu, Andrew H., Wang, Emily, Kim, Haejin, Lamm, Carin I., Bacharier, Leonard B., Pillai, Dinesh, Sigelman, Steve M., Gern, James E., and Busse, William W.

Published
2019
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47. Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial

Author

Yañez, Anahí, Fernández, Marcelo, Tolcachier, Alberto, Belloni, Juan, Taborda, Jorge, De Salvo, Maria, Maspero, Jorge, Victorio, Carlos, Navarta, Miguel Chirino, Grilli, Monica, Rodríguez, Pablo, Otaola, María, Cambursano, Víctor, Malamud, Patricia, Stok, Ana, Arce, German, Roza, Osiris, Scherbovsky, Fernando, Elias, Pedro, Saez, Maria Salazan, Peters, Matthew, Phillips, Martin, Upham, John, Gibson, Peter, Thien, Francis, Douglass, Jo, Thomas, Paul, Bardin, Philip, Sajkov, Dimitar, Hew, Mark, Langton, David, Pez, Andreia, Fritscher, Carlos, Hetzel, Jorge, Mattos, Waldo, Stelmach, Rafael, Antila, Martti, Fernandes, Ana Luisa, Metev, Hristo, Ivanov, Yavor, Bogdanova, Aneliya, Markova, Ana Dancheva, Peneva, Marinka, Veselinova, Rumyana, Petkova, Tatyana, Petrova, Vanushka, Shopova, Elena, Ivanova, Yuliya, Yotsova, Rumyana, Kirkova, Ginka, Petrova, Galina, Dachev, Svetoslav, Sotirova, Kostadinka, Stoyanova, Mariyana, Yakov, Oleg, Ilieva-Fartunova, Vanya, Lemiere, Catherine, Laviolette, Michel, Yang, William, FitzGerald, J Mark, Pek, Bonavuth, Killorn, William Patrick, Poirier, Claude, Chouinard, Guy, Melenka, Lyle, Leigh, Richard, Nair, Parameswaran, Dorscheid, Delbert, Martin, James, Pavie, Juana, Rosenblut, Andres, Cartagena, Claudia, Quilodran, Carlos, Muñoz, Silvia, Malkusova, Ivana, Veverka, Josef, Holub, Stanislav, Mares, Jaroslav, Kozel, Radovan, Kopecka, Daniela, Zindr, Vladimir, Cerva, Pavel, Chanez, Pascal, Bourdin, Arnaud, Devouassoux, Gilles, Taille, Camille, De Blay, Frédéric, Goupil, Francois, Leroyer, Christophe, Gourcerol, Delphine, Didi, Toufik, Didier, Alain, Garcia, Gilles, Bonniaud, Philippe, Vasram, Riazate Rossanaly, Lommatzsch, Marek, Harnest, Ulf, Linnhoff, Anneliese, Keller, Claus, Hoheisel, Gerhard, Förster, Karin, Schultz, Thomas, Schenkenberger, Isabelle, Kirschner, Joachim, Schmoller, Tibor, Zielen, Stefan, Kornmann, Marc, Beck, Ekkehard, Volgmann, Lutz, Dichmann, Rolf, Overlack, Axel, Winkler, Jörg, Mikloweit, Petra, Ballenberger, Sabine, Rolke, Mathias, Korn, Stephanie, Pabel, Helmut, Hoffmann, Martin, Feimer, Jan, Rabe, Klaus, Deckelmann, Regina, Welte, Tobias, Ohbayashi, Hiroyuki, Hozawa, Soichiro, Shimoda, Terufumi, Yoshida, Makoto, Nagakura, Toshikazu, Kamei, Tadashi, Sano, Yasuyuki, Kagami, Shinichiro, Takahashi, Hisaho, Haida, Michiko, Kimura, Goro, Nakamura, Hiroyuki, To, Yasuo, Shinkai, Masaharu, Shimokawaji, Tadasuke, Kudo, Makoto, Shijyubo, Noriharu, Tochigi, Takao, Kato, Motokazu, Tanaka, Akihiko, Gon, Yasuhiro, Sasaki, Norihisa, Ohdaira, Tetsuro, Omori, Chiharu, Takahashi, Toshiki, Takeuchi, Satomi, Nakajima, Kiyotaka, Makita, Hironi, Kaneko, Masahiro, Furuta, Kenjiro, Taniguchi, Masami, Inobe, Yoshito, Miki, Hiroshi, Nakamura, Yoichi, Miyazawa, Naoki, Yano, Shuichi, Iijima, Masayuki, Yamato, Tsuyoshi, Diaz, Javier, Matsuno, Alberto, Felix, Efrain, Guerreros, Alfredo, Daly, Alejandro, Rodriguez Chariarse, Fernando, Salazar, Danilo, Castro, Socorro, Chavez, William, Estrella, Rolando, Aquino, Teresita, Atienza, Tito, Samoro, Ronnie, Isidro, Marie Grace Dawn, Kuna, Piotr, Antczak, Adam, Bednarek, Michał, Mądra-Rogacka, Danuta, Hofman, Teresa, Jutel, Marek, Pisarczyk-Bogacka, Ewa, Kot, Agata, Mróz, Robert, Czupryńska-Borkowska, Małgorzata, Żurowska-Gębala, Małgorzata, Dyczek, Andrzej, Jasieniak-Pinis, Grażyna, Wojnowski, Piotr, Trębas-Pietraś, Ewa, Dobryniewska, Małgorzata, Stobiecki, Marcin, Tarnowska-Matusiak, Marzenna, Magner, Alina, Kolczyński, Andrzej, Kachel, Tomasz, Bartuzi, Zbigniew, Majorek-Olechowska, Bernadetta, Śliwiński, Paweł, Balicka, Violetta, Hajoł, Elżbieta, Stachera, Jacek, Rachel, Marta, Michnar, Marek, Tałałaj, Jarosław, Springer, Ewa, Napora, Piotr, Grzelewski, Tomasz, Bijata-Bronisz, Renata, Świderska, Anna, Mincewicz, Grzegorz, Sankowski, Zbigniew, Fijołek, Tomasz, Kwaśniewski, Artur, Jerzyńska, Joanna, Cygler, Jerzy, Olesiejuk, Ryszard, Von Steiner, Iwona, Machowiak, Wojciech, Filipek, Krzysztof, Piskorz, Piotr, Uhryn, Ewa, Nittner-Marszalska, Marita, Rybicka-Liszewska, Elżbieta, Bodzenta-Łukaszyk, Anna, Chełmińska, Marta, Krupa-Borek, Izabella, Skucha, Wojciech, Płoszczuk, Anna, Mihaescu, Traian, Petrui, Ioan Dorin, Savu, Angelica, Apti, Ghiulten, Toma, Claudia, Trailescu, Ana, Sokurenko, Sergei, Trofimov, Vasiliy, Leshchenko, Igor, Shaporova, Natalia, Ilyashevich, Inna, Stitsenko, Irina, Vizel, Alexander, Ilkovich, Yulia, Tikhanov, Dmitrii, Goncharova, Svetlana, Ezhov, Andrey, Ignatova, Galina, Izmozherova, Nadezhda, Berdnikova, Nadezhda, Goryachkina, Ludmila, Popova, Veronika, Bolieva, Laura, Rebrov, Andrey, Nosov, Vladimir, Magnitskaya, Olga, Nedogoda, Sergey, Abrosimov, Vladimir, Molotkov, Artem, Reshedko, Galina, Smirnov, Mikhail, Osipenko, Marina, Pavlysh, Elena, Myasoedova, Svetlana, Lenskaya, Liudmila, Chistyakov, Valery, Vishneva, Elena, Uon, Liliya, Zateyschikova, Anna, Laleko, Svetlana, Pak, Tatiana, Bruning, Axel, Naidoo, Visvakuren, Reddy, Jeevren, Van Zyl Smit, Richard, Park, Hae-Sim, Cho, Young Joo, Cho, Sang-Heon, Lee, Sang Haak, Lee, Byung Jae, Kim, Ju Sang, Cho, You Sook, Park, Choon-Sik, Kim, Mi-Kyeong, Koh, Young-Il, Kim, Joo-Hee, Lee, Sook Young, Lee, Sang Pyo, Park, Jung Won, Yoo, Kwang Ha, Yoon, Hyoungkyu, Lee, Jaechun, Hur, Gyu-Young, Lee, Soo Keol, Kim, HeeKyoo, Ramos Barbón, David, Laffond Yges, Elena, Martínez Moragón, Eva, Arias Guillen, Miguel, Saura Vinuesa, Alberto, Sánchez-Toril López, Fernando, Velasco Garrido, José Luis, García-Cosio Piqueras, Borja, Pérez de Llano, Luis, Valero Santiago, Antonio Luis, Rubio, Myriam Calle, Bjermer, Leif, Lundbäck, Bo, Gemicioglu, Bilun, Bavbek, Sevim, Ediger, Dane, Erdinc, Munevver, Hanta, Ismail, Nayci, Sibel, Arinc, Sibel, Iashyna, Liudmyla, Mostovoy, Yuriy, Ostrovskyy, Mykola, Kuryk, Lesia, Lemko, Ivan, Ospanova, Tetyana, Moskalenko, Liubov, Korzh, Oleksii, Blazhko, Viktor, Krakhmalova, Olena, Romaniuk, Liliia, Dytyatkovs'ka, Yevgeniya, Yakovenko, Oleh, Gavrysyuk, Volodymyr, Burhan, Hassan, Saralaya, Dinesh, Scott, Stephen, Morice, Alyn, Jackson-Voyzey, Ewart, Win, Thida, Nasser, Shuab, Harrison, Richard, Chaudhuri, Rekha, Nordstrom, Monica, De, Pradip, Masoli, Matthew, Mansur, Adel, Gunstone, Anthony, Niven, Robert, Harrison, Timothy, Babu, Suresh, Bhuchar, Subodh, Kureishy, Shahrukh, Zwetchkenbaum, John, Kaplan, Lawrence, Bleecker, Eugene, Reyes, Santiago, Fakih, Faisal, Heuer, Marvin, Klein, Ryan, Marcus, Michael, Hussain, Iftikhar, Tanus, Tonny, Raissy, Hengameh, Alpizar, Sady, Rodriguez, Hector, Gleich, Gerald, Bridges, Tracy, Pouzar, Joe, Steven, Gary, Matz, Jonathan, Krstevska, Shana, Ziworitin, Dama, Kaplan, Adolfo, Sublett, James, DeAngelo, James, Darter, Amy, Agaiby, John, Hagan, John, Davis, Enrique, Siri, Dareen, Mcevoy, Charlene, Dharma, Chrisette, Karimjee, Najmuddin, Kelsen, Steven, Frade, Manuel, Silverthorn, Amy, Kline, Joel, Averill, Francis, Ruiz, Jose, Robinette, Emory, Shaikh, Zeeshan, Aguilar, Carlos, Nish, William, Alvarez, German, Ismail, Younus, Parikh, Purvi, Leong, Mila, Murphy, Dennis, Garcia, Francisco, Goldsobel, Alan, Blanco, Antonio, Campbell, Edward, Perez, Guido, Chupp, Geoffrey, Bates, Toby, Perez, Vandely, Wenzel, Sally, Shenoy, Kartik, Katial, Rohit, Bernstein, David, Parikh, Neil, Sims, William, Ferguson, Gary, Pham, David, George, Anu, Beasley, Richard, Perez, Gilberto, Garver, Robert, Garcia-Portela, Miriam, Wong, Stephen, Soong, Weily, Guillot, Richard, Hudes, Golda, Arif, Ahmed, Binker, Josefa, Villareal, Manuel, Ziegner, Ulrike, Ojile, Joseph, Goswami, Sanjeev, Piniella, Carlos, Segal, Ilia, Zafra, Heidi, Lee, Mitchell, Tarpay, Martha, Panuto, John, Merchant, Rajan, Springsteen, Peter, Scialla, Timothy, Shapero, Paul, Allen, Karen, Moss, Mark, Cruz, Humberto, Rumbyrt, Jeffrey, Boyd, Amy, Nathan, Robert, Bernstein, Jonathan, Jacobs, Joshua, Ginchansky, Elliot, Johnston, Janice, Baxter, Barbara, Johnson II, Thomas, Apaliski, Stephen, Corder, Clinton, Fuentes, David, Diaz, Joseph, Ngo, Chau, Le, Lan, Busse, William W, Bleecker, Eugene R, Ferguson, Gary T, Barker, Peter, Sproule, Stephanie, Olsson, Richard F, Martin, Ubaldo J, and Goldman, Mitchell

Published
2019
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48. Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children

Author

Lynch, Susan V, Wood, Robert A, Boushey, Homer, Bacharier, Leonard B, Bloomberg, Gordon R, Kattan, Meyer, O’Connor, George T, Sandel, Megan T, Calatroni, Agustin, Matsui, Elizabeth, Johnson, Christine C, Lynn, Henry, Visness, Cynthia M, Jaffee, Katy F, Gergen, Peter J, Gold, Diane R, Wright, Rosalind J, Fujimura, Kei, Rauch, Marcus, Busse, William W, and Gern, James E

Subjects
Asthma, Clinical Research, Perinatal Period - Conditions Originating in Perinatal Period, Prevention, Pediatric, Lung, Aetiology, 2.2 Factors relating to the physical environment, Inflammatory and immune system, Respiratory, Sustainable Cities and Communities, Allergens, Antigens, Bacterial, Bacteria, Case-Control Studies, Child, Preschool, Cohort Studies, Dust, Environmental Exposure, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Male, Recurrence, Respiratory Sounds, Risk, United States, Urban Population, atopy, allergen exposure, microbial exposure, inner city, Immunology, Allergy
Abstract

BackgroundWheezing illnesses cause major morbidity in infants and are frequent precursors to asthma.ObjectiveWe sought to examine environmental factors associated with recurrent wheezing in inner-city environments.MethodsThe Urban Environment and Childhood Asthma study examined a birth cohort at high risk for asthma (n = 560) in Baltimore, Boston, New York, and St Louis. Environmental assessments included allergen exposure and, in a nested case-control study of 104 children, the bacterial content of house dust collected in the first year of life. Associations were determined among environmental factors, aeroallergen sensitization, and recurrent wheezing at age 3 years.ResultsCumulative allergen exposure over the first 3 years was associated with allergic sensitization, and sensitization at age 3 years was related to recurrent wheeze. In contrast, first-year exposure to cockroach, mouse, and cat allergens was negatively associated with recurrent wheeze (odds ratio, 0.60, 0.65, and 0.75, respectively; P ≤ .01). Differences in house dust bacterial content in the first year, especially reduced exposure to specific Firmicutes and Bacteriodetes, was associated with atopy and atopic wheeze. Exposure to high levels of both allergens and this subset of bacteria in the first year of life was most common among children without atopy or wheeze.ConclusionsIn inner-city environments children with the highest exposure to specific allergens and bacteria during their first year were least likely to have recurrent wheeze and allergic sensitization. These findings suggest that concomitant exposure to high levels of certain allergens and bacteria in early life might be beneficial and suggest new preventive strategies for wheezing and allergic diseases.

Published
2014

50. Gene-based association study of rare variants in children of diverse ancestries implicates TNFRSF21 in the development of allergic asthma

Author

Clay, Selene, primary, Alladina, Jehan, additional, Smith, Neal P., additional, Visness, Cynthia M., additional, Wood, Robert A., additional, O’Connor, George T., additional, Cohen, Robyn T., additional, Khurana Hershey, Gurjit K., additional, Kercsmar, Carolyn M., additional, Gruchalla, Rebecca S., additional, Gill, Michelle A., additional, Liu, Andrew H., additional, Kim, Haejin, additional, Kattan, Meyer, additional, Bacharier, Leonard B., additional, Rastogi, Deepa, additional, Rivera-Spoljaric, Katherine, additional, Robison, Rachel G., additional, Gergen, Peter J., additional, Busse, William W., additional, Villani, Alexandra-Chloe, additional, Cho, Josalyn L., additional, Medoff, Benjamin D., additional, Gern, James E., additional, Jackson, Daniel J., additional, Ober, Carole C., additional, and Dapas, Matthew, additional

Published
2023
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