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9. Typing of inflammatory lesions of the pituitary

Author

Warmbier, J., primary, Lüdecke, D. K., additional, Flitsch, J., additional, Buchfelder, M., additional, Fahlbusch, R., additional, Knappe, U. J., additional, Kreutzer, J., additional, Buslei, R., additional, Bergmann, M., additional, Heppner, F., additional, Glatzel, M., additional, and Saeger, W., additional

Published
2021
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10. Intimal sarcomas and undifferentiated cardiac sarcomas carry mutually exclusive MDM2, MDM4, and CDK6 amplifications and share a common DNA methylation signature

Author

Koelsche, C., Benhamida, J.K., Kommoss, F.K.F., Stichel, D., Jones, D.T.W., Pfister, S.M., Heilig, C.E., Fröhling, S., Stenzinger, A., Buslei, R., Mentzel, T., Baumhoer, D., Ladanyi, M., Antonescu, C.R., Flucke, U.E., Gorp, J.V., Bode-Lesniewska, B., Deimling, A.V., Mechtersheimer, G., Koelsche, C., Benhamida, J.K., Kommoss, F.K.F., Stichel, D., Jones, D.T.W., Pfister, S.M., Heilig, C.E., Fröhling, S., Stenzinger, A., Buslei, R., Mentzel, T., Baumhoer, D., Ladanyi, M., Antonescu, C.R., Flucke, U.E., Gorp, J.V., Bode-Lesniewska, B., Deimling, A.V., and Mechtersheimer, G.

Abstract

Item does not contain fulltext, Undifferentiated mesenchymal tumors arising from the inner lining (intima) of large arteries are classified as intimal sarcomas (ISA) with MDM2 amplification as their molecular hallmark. Interestingly, undifferentiated pleomorphic sarcomas (UPS) of the heart have recently been suggested to represent the cardiac analog of ISA due to morphological overlap and high prevalence of MDM2 amplifications in both neoplasms. However, little is known about ISAs and cardiac UPS without MDM2 amplifications and molecular data supporting their common classification is sparse. Here, we report a series of 35 cases comprising 25 ISAs of the pulmonary artery, one ISA of the renal artery and 9 UPS of the left atrium. Tumors were analyzed utilizing the Illumina Infinium MethylationEPIC BeadChip array, enabling copy number profile generation and unsupervised DNA methylation analysis. DNA methylation patterns were investigated using t-distributed stochastic neighbor embedding (t-SNE) analysis. Histologically, all ISAs and UPS of the left atrium resembled extra-cardiac UPS. All cases exhibited highly complex karyotypes with overlapping patterns between ISA and UPS. 29/35 cases showed mutually exclusive amplifications in the cell-cycle associated oncogenes MDM2 (25/35), MDM4 (2/35), and CDK6 (2/35). We further observed recurrent co-amplifications in PDGFRA (21/35), CDK4 (15/35), TERT (11/35), HDAC9 (9/35), and CCND1 (4/35). Sporadic co-amplifications occurred in MYC, MYCN, and MET (each 1/35). The tumor suppressor CDKN2A/B was frequently deleted (10/35). Interestingly, DNA methylation profiling (t-SNE) revealed an overlap of ISA and cardiac UPS. This "ISA" methylation signature was distinct from potential histologic and molecular mimics. In conclusion, our data reveal MDM4 and CDK6 amplifications in ISAs and UPS of the left atrium, lacking MDM2 amplification. We further report novel co-amplifications of various oncogenes, which may have therapeutic implications. Finally, the genetic and epig

Published
2021

11. Deciphering the genetic and epigenetic background of silent and non-silent ACTH adenomas

Author

Ricklefs, FL, Fita, K, Rotermund, R, Piffko, A, Schmid, S, Capper, D, Buslei, R, Buchfelder, M, Burkhardt, T, Matschke, J, Westphal, M, Lamszus, K, Schüller, U, Flitsch, J, Ricklefs, FL, Fita, K, Rotermund, R, Piffko, A, Schmid, S, Capper, D, Buslei, R, Buchfelder, M, Burkhardt, T, Matschke, J, Westphal, M, Lamszus, K, Schüller, U, and Flitsch, J

Published
2021

12. Sarcoma classification by DNA methylation profiling

Author

Koelsche, C, Schrimpf, D, Stichel, D, Sill, M, Sahm, F, Reuss, DE, Blattner, M, Worst, B, Heilig, CE, Beck, K, Horak, P, Kreutzfeldt, S, Paff, E, Stark, S, Johann, P, Selt, F, Ecker, J, Sturm, D, Pajtler, K W, Reinhardt, A, Wefers, AK, Sievers, P, Ebrahimi, A, Suwala, A, Fernandez-Klett, F, Casalini, B, Korshunov, A, Hovestadt, V, Kommoss, FKF, Kriegsmann, M, Schick, M, Bewerunge-Hudler, M, Milde, T, Witt, O, Kulozik, AE, Kool, M, Romero-Perez, L, Grunewald, TGP, Kirchner, T, Wick, W, Platten, M, Unterberg, A, Uhl, M, Abdollahi, A, Debus, J, Lehner, B, Thomas, C, Hasselblatt, M, Paulus, W, Hartmann, C, Staszewski, O, Prinz, M, Hench, J, Frank, S, Versleijen-Jonkers, YMH, Weidema, ME, Mentzel, T, Griewank, K, Alava, E, Martin, JD, Gastearena, MAI, Chang, KTE, Low, SYY, Cuevas-Bourdier, A, Mittelbronn, M, Mynarek, M, Rutkowski, S, Schuller, U, Mautner, VF, Schittenhelm, J, Serrano, J, Snuderl, M, Buttner, R, Klingebiel, T, Buslei, R, Gessler, M, Wesseling, P, Dinjens, Winand, Brandner, S, Jaunmuktane, Z, Lyskjaer, I, Schirmacher, P, Stenzinger, A, Brors, B, Glimm, H, Heining, C, Tirado, OM, Sainz-Jaspeado, M, Mora, J, Alonso, J, del Muro, XG, Moran, S, Esteller, M, Benhamida, JK, Ladanyi, M, Wardelmann, E, Antonescu, C, Flanagan, A, Dirksen, U, Hohenberger, P, Baumhoer, D, Hartmann, W, Vokuhl, C, Flucke, U, Petersen, I, Mechtersheimer, G, Capper, D, Jones, DT, Frohling, S, Pfister, SM, von Deimling, A, Koelsche, C, Schrimpf, D, Stichel, D, Sill, M, Sahm, F, Reuss, DE, Blattner, M, Worst, B, Heilig, CE, Beck, K, Horak, P, Kreutzfeldt, S, Paff, E, Stark, S, Johann, P, Selt, F, Ecker, J, Sturm, D, Pajtler, K W, Reinhardt, A, Wefers, AK, Sievers, P, Ebrahimi, A, Suwala, A, Fernandez-Klett, F, Casalini, B, Korshunov, A, Hovestadt, V, Kommoss, FKF, Kriegsmann, M, Schick, M, Bewerunge-Hudler, M, Milde, T, Witt, O, Kulozik, AE, Kool, M, Romero-Perez, L, Grunewald, TGP, Kirchner, T, Wick, W, Platten, M, Unterberg, A, Uhl, M, Abdollahi, A, Debus, J, Lehner, B, Thomas, C, Hasselblatt, M, Paulus, W, Hartmann, C, Staszewski, O, Prinz, M, Hench, J, Frank, S, Versleijen-Jonkers, YMH, Weidema, ME, Mentzel, T, Griewank, K, Alava, E, Martin, JD, Gastearena, MAI, Chang, KTE, Low, SYY, Cuevas-Bourdier, A, Mittelbronn, M, Mynarek, M, Rutkowski, S, Schuller, U, Mautner, VF, Schittenhelm, J, Serrano, J, Snuderl, M, Buttner, R, Klingebiel, T, Buslei, R, Gessler, M, Wesseling, P, Dinjens, Winand, Brandner, S, Jaunmuktane, Z, Lyskjaer, I, Schirmacher, P, Stenzinger, A, Brors, B, Glimm, H, Heining, C, Tirado, OM, Sainz-Jaspeado, M, Mora, J, Alonso, J, del Muro, XG, Moran, S, Esteller, M, Benhamida, JK, Ladanyi, M, Wardelmann, E, Antonescu, C, Flanagan, A, Dirksen, U, Hohenberger, P, Baumhoer, D, Hartmann, W, Vokuhl, C, Flucke, U, Petersen, I, Mechtersheimer, G, Capper, D, Jones, DT, Frohling, S, Pfister, SM, and von Deimling, A

Abstract

Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and children. They represent a morphologically heterogeneous class of tumours and some entities lack defining histopathological features. Therefore, the diagnosis of sarcomas is burdened with a high inter-observer variability and misclassification rate. Here, we demonstrate classification of soft tissue and bone tumours using a machine learning classifier algorithm based on array-generated DNA methylation data. This sarcoma classifier is trained using a dataset of 1077 methylation profiles from comprehensively pre-characterized cases comprising 62 tumour methylation classes constituting a broad range of soft tissue and bone sarcoma subtypes across the entire age spectrum. The performance is validated in a cohort of 428 sarcomatous tumours, of which 322 cases were classified by the sarcoma classifier. Our results demonstrate the potential of the DNA methylation-based sarcoma classification for research and future diagnostic applications.

Published
2021

17. Genome-wide methylation profiling and copy number analysis in atypical fibroxanthomas and pleomorphic dermal sarcomas indicate a similar molecular phenotype

Author

Koelsche, C., Stichel, D., Griewank, K.G., Schrimpf, D., Reuss, D.E., Bewerunge-Hudler, M., Vokuhl, C., Dinjens, W.N., Petersen, I., Mittelbronn, M., Cuevas-Bourdier, A., Buslei, R., Pfister, S.M., Flucke, U.E., Mechtersheimer, G., Mentzel, T., Deimling, A. von, Koelsche, C., Stichel, D., Griewank, K.G., Schrimpf, D., Reuss, D.E., Bewerunge-Hudler, M., Vokuhl, C., Dinjens, W.N., Petersen, I., Mittelbronn, M., Cuevas-Bourdier, A., Buslei, R., Pfister, S.M., Flucke, U.E., Mechtersheimer, G., Mentzel, T., and Deimling, A. von

Abstract

Contains fulltext : 203163.pdf (publisher's version ) (Open Access), Background: Atypical fibroxanthomas (AFX) and pleomorphic dermal sarcomas (PDS) are lesions of the skin with overlapping histologic features and unspecific molecular traits. PDS behaves aggressive compared to AFX. Thus, a precise delineation, although challenging in some instances, is relevant. Methods: We examined the value of DNA-methylation profiling and copy number analysis for separating these tumors. DNA-methylation data were generated from 17 AFX and 15 PDS using the Illumina EPIC array. These were compared with DNA-methylation data generated from 196 tumors encompassing potential histologic mimics like cutaneous squamous carcinomas (cSCC; n = 19), basal cell carcinomas (n = 10), melanoma metastases originating from the skin (n = 11), leiomyosarcomas (n = 11), angiosarcomas of the skin and soft tissue (n = 11), malignant peripheral nerve sheath tumors (n = 19), dermatofibrosarcomas protuberans (n = 13), extraskeletal myxoid chondrosarcomas (n = 9), myxoid liposarcomas (n = 14), schwannomas (n = 10), neurofibromas (n = 21), alveolar (n = 19) and embryonal (n = 17) rhabdomyosarcomas as well as undifferentiated pleomorphic sarcomas (n = 12). Results: DNA-methylation profiling did not separate AFX from PDS. The DNA-methylation profiles of the other cases, however, were distinct from AFX/PDS. They reliably assigned to subtype-specific DNA-methylation clusters, although overlap occurred between some AFX/PDS and cSCC. Copy number profiling revealed alterations in a similar frequency and distribution between AFX and PDS. They involved losses of 9p (22/32) and 13q (25/32). Gains frequently involved 8q (8/32). Notably, a homozygous deletion of CDKN2A was more frequent in PDS (6/15) than in AFX (2/17), whereas amplifications were non-recurrent and overall rare (5/32). Conclusions: Our findings support the concept that AFX and PDS belong to a common tumor spectrum. We could demonstrate the diagnostic value of DNA-methylation profiling to delineating AFX/PDS from potentia

Published
2019

18. SAMD14/NEURABIN-I AS BCR-ANTIGENS OF PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA

Author

Thurner, L., primary, Bewarder, M., additional, Fadle, N., additional, Regitz, E., additional, Poeschel, V., additional, Ziepert, M., additional, Schuck, R., additional, Altmeyer, S., additional, Kemele, M., additional, Bock, T., additional, Schormann, C., additional, Walter, S., additional, Szczepanowski, M., additional, Klapper, W., additional, Monoranu, C., additional, Rosenwald, A., additional, Moeller, P., additional, Kim, Y., additional, Buslei, R., additional, Kaddu-Mulindwa, D., additional, Neumann, F., additional, Roemer, K., additional, Bohle, R., additional, Illerhaus, G., additional, Schorb, E., additional, Schaefer, H., additional, Hansmann, M.L., additional, Hartmann, S., additional, Held, G., additional, Stilgenbauer, S., additional, Murawski, N., additional, Pfreundschuh, M., additional, and Preuss, K.D., additional

Published
2019
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19. DNA methylation-based classification of central nervous system tumours

Author

Capper, D, Jones, DTW, Sill, M, Hovestadt, V, Schrimpf, D, Sturm, D, Koelsche, C, Sahm, F, Chavez, L, Reuss, DE, Kratz, A, Wefers, AK, Huang, K, Pajtler, KW, Schweizer, L, Stichel, D, Olar, A, Engel, NW, Lindenberg, K, Harter, PN, Braczynski, AK, Plate, KH, Dohmen, H, Garvalov, BK, Coras, R, Hoelsken, A, Hewer, E, Bewerunge-Hudler, M, Schick, M, Fischer, R, Beschorner, R, Schittenhelm, J, Staszewski, O, Wani, K, Varlet, P, Pages, M, Temming, P, Lohmann, D, Selt, F, Witt, H, Milde, T, Witt, O, Aronica, E, Giangaspero, F, Rushing, E, Scheurlen, W, Geisenberger, C, Rodriguez, FJ, Becker, A, Preusser, M, Haberler, C, Bjerkvig, R, Cryan, J, Farrell, M, Deckert, M, Hench, J, Frank, S, Serrano, J, Kannan, K, Tsirigos, A, Brueck, W, Hofer, S, Brehmer, S, Seiz-Rosenhagen, M, Haenggi, D, Hans, V, Rozsnoki, S, Hansford, JR, Kohlhof, P, Kristensen, BW, Lechner, M, Lopes, B, Mawrin, C, Ketter, R, Kulozik, A, Khatib, Z, Heppner, F, Koch, A, Jouvet, A, Keohane, C, Muehleisen, H, Mueller, W, Pohl, U, Prinz, M, Benner, A, Zapatka, M, Gottardo, NG, Driever, PH, Kramm, CM, Mueller, HL, Rutkowski, S, von Hoff, K, Fruehwald, MC, Gnekow, A, Fleischhack, G, Tippelt, S, Calaminus, G, Monoranu, C-M, Perry, A, Jones, C, Jacques, TS, Radlwimmer, B, Gessi, M, Pietsch, T, Schramm, J, Schackert, G, Westphal, M, Reifenberger, G, Wesseling, P, Weller, M, Collins, VP, Bluemcke, I, Bendszus, M, Debus, J, Huang, A, Jabado, N, Northcott, PA, Paulus, W, Gajjar, A, Robinson, GW, Taylor, MD, Jaunmuktane, Z, Ryzhova, M, Platten, M, Unterberg, A, Wick, W, Karajannis, MA, Mittelbronn, M, Acker, T, Hartmann, C, Aldape, K, Schueller, U, Buslei, R, Lichter, P, Kool, M, Herold-Mende, C, Ellison, DW, Hasselblatt, M, Snuderl, M, Brandner, S, Korshunov, A, von Deimling, A, Pfister, SM, Capper, D, Jones, DTW, Sill, M, Hovestadt, V, Schrimpf, D, Sturm, D, Koelsche, C, Sahm, F, Chavez, L, Reuss, DE, Kratz, A, Wefers, AK, Huang, K, Pajtler, KW, Schweizer, L, Stichel, D, Olar, A, Engel, NW, Lindenberg, K, Harter, PN, Braczynski, AK, Plate, KH, Dohmen, H, Garvalov, BK, Coras, R, Hoelsken, A, Hewer, E, Bewerunge-Hudler, M, Schick, M, Fischer, R, Beschorner, R, Schittenhelm, J, Staszewski, O, Wani, K, Varlet, P, Pages, M, Temming, P, Lohmann, D, Selt, F, Witt, H, Milde, T, Witt, O, Aronica, E, Giangaspero, F, Rushing, E, Scheurlen, W, Geisenberger, C, Rodriguez, FJ, Becker, A, Preusser, M, Haberler, C, Bjerkvig, R, Cryan, J, Farrell, M, Deckert, M, Hench, J, Frank, S, Serrano, J, Kannan, K, Tsirigos, A, Brueck, W, Hofer, S, Brehmer, S, Seiz-Rosenhagen, M, Haenggi, D, Hans, V, Rozsnoki, S, Hansford, JR, Kohlhof, P, Kristensen, BW, Lechner, M, Lopes, B, Mawrin, C, Ketter, R, Kulozik, A, Khatib, Z, Heppner, F, Koch, A, Jouvet, A, Keohane, C, Muehleisen, H, Mueller, W, Pohl, U, Prinz, M, Benner, A, Zapatka, M, Gottardo, NG, Driever, PH, Kramm, CM, Mueller, HL, Rutkowski, S, von Hoff, K, Fruehwald, MC, Gnekow, A, Fleischhack, G, Tippelt, S, Calaminus, G, Monoranu, C-M, Perry, A, Jones, C, Jacques, TS, Radlwimmer, B, Gessi, M, Pietsch, T, Schramm, J, Schackert, G, Westphal, M, Reifenberger, G, Wesseling, P, Weller, M, Collins, VP, Bluemcke, I, Bendszus, M, Debus, J, Huang, A, Jabado, N, Northcott, PA, Paulus, W, Gajjar, A, Robinson, GW, Taylor, MD, Jaunmuktane, Z, Ryzhova, M, Platten, M, Unterberg, A, Wick, W, Karajannis, MA, Mittelbronn, M, Acker, T, Hartmann, C, Aldape, K, Schueller, U, Buslei, R, Lichter, P, Kool, M, Herold-Mende, C, Ellison, DW, Hasselblatt, M, Snuderl, M, Brandner, S, Korshunov, A, von Deimling, A, and Pfister, SM

Abstract

Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging-with substantial inter-observer variability in the histopathological diagnosis of many tumour types. Here we present a comprehensive approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups, and demonstrate its application in a routine diagnostic setting. We show that the availability of this method may have a substantial impact on diagnostic precision compared to standard methods, resulting in a change of diagnosis in up to 12% of prospective cases. For broader accessibility, we have designed a free online classifier tool, the use of which does not require any additional onsite data processing. Our results provide a blueprint for the generation of machine-learning-based tumour classifiers across other cancer entities, with the potential to fundamentally transform tumour pathology.

Published
2018

20. Pathology of Pituicytoma – Indicators for treatment alternatives?

Author

Mende, C, Matschke, J, Buslei, R, Saeger, W, Fahlbusch, R, Buchfelder, M, Westphal, M, and Flitsch, J

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: Pituicytoma is a rare neoplasm of the sellar region, believed to originate from neurohypophyseal cells. Tumor resection is the primary treatment option, but may remain incomplete due to excessive bleeding of the well vascluarized tumor stroma. Therefore the search for alternative or additional[for full text, please go to the a.m. URL], 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS)

Published
2017
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21. Craniopharyngioma

Author

Buslei, R, Rushing, Ej, Giangaspero, Felice, Paulus, W, Burger, Pc, and Santagata, S.

Published
2016

23. DNA methylation array-based molecular profiling for brain tumor classification

Author

Capper, D, Jones, DTW, Sill, M, Hovestadt, V, Schrimpf, D, Reuss, D, Sahm, F, Kölsche, C, Kratz, A, Mittelbronn, M, Schittenhelm, J, Olar, A, Buslei, R, Hartmann, C, Kohlhof, P, Hasselblatt, M, Schick, M, Bewerunge-Hudler, M, Korshunov, A, Aldape, K, von Deimling, A, and Pfister, SM

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Question/methods: Molecular technologies which can complement standard pathology testing have the potential to greatly enhance diagnostic precision. Analysis of DNA methylation, acting as a 'fingerprint' of cellular origin, is one such promising technology for tumor classification. We[for full text, please go to the a.m. URL], 60th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN)

Published
2015
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28. Combined alterations in MAPK pathway genes, CDKN2A/B and ATRX characterize anaplastic pilocytic astrocytoma

Author

Kratz, A, Sahm, F, Schrimpf, D, Jones, DT, Reuss, D, Koelsche, C, Huang, K, Wefers, AK, Hovestadt, V, Gramatzki, D, Felsberg, J, Koch, A, Thomale, UW, Reifenberger, G, Becker, A, Hans, V, Prinz, M, Staszewski, O, Acker, T, Dohmen-Scheufler, H, Hartmann, C, Mueller, W, Tuffaha, MSA, Paulus, W, Heß, K, Brokinkel, B, Schittenhelm, J, Monoranu, CM, Kessler, AF, Loehr, M, Buslei, R, Deckert, M, Mawrin, C, Kohlhof, P, Hewer, E, Olar, A, Rodriguez, F, Giannini, C, NageswaraRao, AA, Weller, M, Pohl, U, Brandner, S, Pfister, SM, von Deimling, A, Capper, D, Kratz, A, Sahm, F, Schrimpf, D, Jones, DT, Reuss, D, Koelsche, C, Huang, K, Wefers, AK, Hovestadt, V, Gramatzki, D, Felsberg, J, Koch, A, Thomale, UW, Reifenberger, G, Becker, A, Hans, V, Prinz, M, Staszewski, O, Acker, T, Dohmen-Scheufler, H, Hartmann, C, Mueller, W, Tuffaha, MSA, Paulus, W, Heß, K, Brokinkel, B, Schittenhelm, J, Monoranu, CM, Kessler, AF, Loehr, M, Buslei, R, Deckert, M, Mawrin, C, Kohlhof, P, Hewer, E, Olar, A, Rodriguez, F, Giannini, C, NageswaraRao, AA, Weller, M, Pohl, U, Brandner, S, Pfister, SM, von Deimling, A, and Capper, D

Published
2016

30. Treatment with temozolomide in aggressive pituitary tumors - data from a survey by the German Pituitary Study Group

Author

Schlaffer, S., Buchfelder, M., Droste, M., Elbelt, U., Bojunga, J., Flitsch, J., Honegger, J., Kolenda, H., Lammert, A., Buslei, R., Saeger, W., Petersenn, Stephan, and German Pituitary Study Grp

Subjects
Oncology, medicine.medical_specialty, Temozolomide, business.industry, Endocrinology, Diabetes and Metabolism, Pituitary tumors, Medizin, General Medicine, medicine.disease, language.human_language, German, Endocrinology, Internal medicine, Internal Medicine, language, medicine, business, medicine.drug
Published
2013

31. What are the causes of headache in patients with pituitary adenomas?

Author

Carneiro, RW, Siegel, S, Buslei, R, Brabant, G, Buchfelder, M, and Kreitschmann-Andermahr, I

Subjects
ddc: 610, Pituitary Adenomas, Headache, 610 Medical sciences, Medicine
Abstract

Objective: Headache is present in approximately one third of patients with pituitary adenomas. It is supposedly related to tumor size or cavernous sinus invasion and probably caused by traction or displacement of intracranial pain-sensitive structures such as blood vessels, cranial nerves and dura mater.[for full text, please go to the a.m. URL], 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Published
2013
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32. Fungal abscess – a rare differential diagnosis of pituitary pathology for the neurosurgeon

Author

Rappert, D, Kreitschmann-Andermahr, I, Buslei, R, Schlaffer, SM, Kloska, S, and Buchfelder, M

Subjects
ddc: 610, sella turcica/surgery, abscess, aspergillosis, 610 Medical sciences, Medicine
Abstract

Objective: Fungal abscess is an extremely rare sellar mass lesion with only a handful of cases described in the literature. Infection is often related to immunodeficiency. Herein, we present our own patient series with intrasellar fungal lesions. Method: We screened the histopathological database[for full text, please go to the a.m. URL], 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Published
2013
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43. RESULTS OF THE INTERNATIONAL INTERLABORATORY COMPARISON OF MGMT PROMOTER METHYLATION ANALYSIS INVOLVING TWENTY-THREE ACADEMIC CENTERS IN GERMANY, AUSTRIA AND THE NETHERLANDS

Author

Reifenberger, G., primary, Malzkorn, B., additional, Acker, T., additional, Bettstetter, M., additional, Buslei, R., additional, von Deimling, A., additional, Dietmaier, W., additional, Dubbink, H. J., additional, Eigenbrod, S., additional, Garvalov, B. K., additional, Gerstenmaier, U., additional, Giese, A., additional, Haase, D., additional, Hasselblatt, M., additional, Kirches, E., additional, Koch, A., additional, Marienfeld, R., additional, Mittelbronn, M., additional, Montesinos-Rongen, M., additional, Pagenstecher, A., additional, Riemenschneider, M. J., additional, Prinz, M., additional, Romeike, B., additional, Roos, A., additional, Spiegl-Kreinecker, S., additional, Schittenhelm, J., additional, Schlegel, J., additional, Thal, D. R., additional, Tops, B. B. J., additional, Weis, J., additional, Westphal, G., additional, Worm, K., additional, and Felsberg, J., additional

Published
2014
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45. The driving force of craniopharyngioma growth

Author

Stache, C, primary, Hölsken, A, additional, Schlaffer, SM, additional, Hess, A, additional, Metzler, M, additional, Fahlbusch, R, additional, Flitsch, J, additional, Buchfelder, M, additional, and Buslei, R, additional

Published
2014
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