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5. Dunne darm

Author

Buskens, C. J., van der Bilt, J. D. W., Heineman, E., editor, Heineman, D.J., editor, Lange jr., J.F.M., editor, Blankensteijn, J.D., editor, Boermeester, M.A., editor, Borel Rinkes, I.H.M., editor, Klaase, J.M., editor, Schipper, I.B., editor, Schreurs, W.H., editor, and Wijnen, R.M.H., editor

Published
2021
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7. P934 A delphi consensus on the optimisation of medical and surgical therapy in perianal fistulising Crohn’s disease, targeted at individual TOpCLASS classification groups

Author

Hanna, L, primary, Anandabaskaran, S, additional, Iqbal, N, additional, Geldof, J, additional, LeBlanc, J F, additional, Dige, A, additional, Lundby, L, additional, Bislenghi, G, additional, Verstockt, B, additional, D'Hoore, A, additional, Vermeire, S, additional, De Looze, D, additional, Lobaton, T, additional, Van de Putte, D, additional, De Kock, I, additional, Carvello, M, additional, Spinelli, A, additional, Danese, S, additional, Buskens, C J, additional, Gecse, K, additional, Hompes, R, additional, van der Bilt, J D W, additional, Bemelman, W A, additional, Sebastian, S, additional, Moran, G W, additional, Lightner, A, additional, Wong, S Y, additional, Cohen, B L, additional, Holubar, S, additional, Ding, N S, additional, Behrenbruch, C, additional, Sahnan, K, additional, Misra, R, additional, Lung, P, additional, Hart, A, additional, and Tozer, P, additional

Published
2024
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9. P818 Imaging-based preoperative body composition is associated with the risk of postoperative complications and postoperative endoscopic recurrence in patients with Crohn’s disease

Author

Bak, M, primary, Demers, K, additional, van Ruler, O, additional, Pierik, M J, additional, van der Bilt, J D W, additional, Romberg-Camps, M, additional, Dijkstra, G, additional, Duijvestein, M, additional, van der Marel, S, additional, Maljaars, P W J, additional, Buskens, C J, additional, Bakers, F C H, additional, van Dijk, D P J, additional, Brecheisen, R, additional, Bongers, B C, additional, van Rossum, E F C, additional, de Witte, D, additional, Jansen, S V, additional, Jharap, B J H, additional, Horjus, C S, additional, van Schaik, F D M, additional, West, R L, additional, de Boer, N K H, additional, van der Woude, C J, additional, Stassen, L P S, additional, and de Vries, A C, additional

Published
2024
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18. Platelet-Rich stroma from Crohn's disease patients for treatment of perianal fistula shows a higher myeloid cell profile compared to non-IBD controls

Author

Arkenbosch, J. H.C., Becker, M. A.J., Buskens, C. J., Witjes, C., de Vries, A. C., van der Woude, C. J., Fuhler, G., Wildenberg, M. E., van Ruler, O., Arkenbosch, J. H.C., Becker, M. A.J., Buskens, C. J., Witjes, C., de Vries, A. C., van der Woude, C. J., Fuhler, G., Wildenberg, M. E., and van Ruler, O.

Abstract

Background: New cell-based therapies are under investigation to improve perianal fistulizing Crohn's disease (pCD) healing. Autologous stromal vascular fraction combined with platelet-rich plasma (referred to as platelet-rich stroma [PRS]) is a new adipose-derived stromal therapy. The effect of Crohn's disease (CD) on adipose tissue, and adipose-derived therapies, is largely unknown. We characterized the cellular composition of subcutaneous lipoaspirate and PRS of pCD patients and non-Inflammatory Bowel Disease (IBD) controls. Methods: Consecutive pCD patients (≥18 years) and non-IBD controls, who underwent liposuction for the purpose of autologous PRS therapy, were included (October 2020 and March 2021). Mechanically fractionated lipoaspirate and the combined PRS product were analyzed for cell surface marker expression using fluorescence-activated cell sorting analysis. Results: Twenty-three patients (37.8 [IQR 30.7–45.0] years; 9 [39.1 %] male; 11CD patients) were included. Similar total number of cells were found in CD and non-IBD lipoaspirate (CD 8.23 ± 1.62*105 cells/mL versus non-IBD 12.20 ± 3.39*105). Presence of stromal cells, endothelial like cells, immune cells, T-cells, myeloid cells and M2/M1 macrophage ratio were similar in CD and non-IBD lipoaspirate. In PRS samples, more cells/mL were seen in CD patients (P = 0.030). Myeloid cells were more abundant in CD PRS samples (P = 0.007), and appeared to have a higher regulatory M2/M1 ratio. Interdonor variation was observed between lipoaspirate and PRS samples. Conclusions: The composition of CD and non-IBD lipoaspirate were found to be similar and interdonor variation was observed. However, PRS from CD patients showed more myeloid cells with a regulatory phenotype. Crohn's disease does not appear to alter the immunological composition of adipose-derived products.

Published
2023

20. P486 Improving enhanced recovery after surgery (ERAS): the effect of a patient-centred mobile application on patient participation in colorectal surgery

Author

Van Der Storm, S L, primary, Jansen, M, additional, Marsman, H A, additional, Molly, G P, additional, Consten, E C, additional, Groot, L M, additional, Boer, F C, additional, Corver, M, additional, Oosterling, S J, additional, Tuynman, J B, additional, Bemelman, W A, additional, Buskens, C J, additional, and Schijven, M P, additional

Published
2023
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22. P326 PREFAB-study: PRediction tool for Early identification of patients at risk of Crohn's disease in perianal Fistulas and ABscesses: interim analysis of a prospective pilot study at a non-academic, IBD-expert centre in the Netherlands

Author

Munster, L, primary, de Groof, E J, additional, van Dieren, S, additional, Mundt, M W, additional, D’Haens, G R A M, additional, Bemelman, W A, additional, Buskens, C J, additional, and van der Bilt, J D W, additional

Published
2023
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24. P447 Early predictors of the need for surgery in patients with acute severe ulcerative colitis: results of the prospective, observational, international ESCP MASC study

Author

Frasson, M, primary, Pinkney, T, additional, Gisbert, J P, additional, Rodriguez-Lago, I, additional, Blackwell, S, additional, Gecse, K B, additional, Buskens, C J, additional, Knowles, C, additional, Zmora, O, additional, Brookes, M, additional, Fiorino, G, additional, Nos, P, additional, Gallo, G, additional, Pata, F, additional, Verjee, A, additional, Leone, S, additional, and Pellino, G, additional

Published
2023
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27. Laparoscopic peritoneal lavage or sigmoidectomy for perforated diverticulitis with purulent peritonitis: a multicentre, parallel-group, randomised, open-label trial

Author

Hop, W C, Opmeer, B C, Reitsma, J B, Scholte, R A, Waltmann, E W H, Legemate, D A, Bartelsman, J F, Meijer, D W, de Brouwer, M, van Dalen, J, Durbridge, M, Geerdink, M, Ilbrink, G J, Mehmedovic, S, Middelhoek, P, Di Saverio, Salomone, Boom, M J, Consten, E C J, van der Bilt, J D W, van Olden, G D J, Stam, M A W, Verweij, M S, Busch, O R C, Buskens, C J, El-Massoudi, Y, Kluit, A B, van Rossem, C C, Schijven, M P, Tanis, P J, Unlu, C, Gerhards, M F, Karsten, T M, de Nes, L C, Rijna, H, van Wagensveld, B A, Koffeman, G I, Steller, E P, Tuynman, J B, Bruin, S C, van der Peet, D L, Blanken-Peeters, C F J M, Cense, H A, Jutte, E, Crolla, R M P H, van der Schelling, G P, van Zeeland, M, de Graaf, E J R, Groenendijk, R P R, Vermaas, M, Schouten, O, de Vries, M R, Prins, H A, Lips, D J, Bosker, R J I, van der Hoeven, J A B, Diks, J, Plaisier, P W, Kruyt, P M, Sietses, C, Stommel, M W J, Nienhuijs, S W, de Hingh, I H J T, Luyer, M D P, van Montfort, G, Ponten, E H, Smulders, J F, van Duyn, E B, Klaase, J M, Swank, D J, Ottow, R T, Stockmann, H B A C, Vermeulen, J, Vuylsteke, R J C L M, Belgers, H J, Fransen, S, von Meijenfeldt, E M, Sosef, M N, van Geloven, A A W, Hendriks, E R, ter Horst, B, Leeuwenburgh, M M N, van Ruler, O, Vogten, J M, Vriens, E J C, Westerterp, M, Eijsbouts, Q A J, Bentohami, A, Bijlsma, T S, de Korte, N, Nio, D, Govaert, M J P M, Joosten, J J A, Tollenaar, R A E M, Stassen, L P S, Wiezer, M J, Hazebroek, E J, Smits, A B, van Westreenen, H L, Lange, J F, Brandt, A, Nijboer, W N, Toorenvliet, B R, Weidema, W F, Coene, P P L O, Mannaerts, G H H, den Hartog, D, de Vos, R J, Zengerink, J F, Hoofwijk, A G M, Hulsewé, K W E, Melenhorst, J, Stoot, J H M B, Steup, W H, Huijstee, P J, Merkus, J W S, Wever, J J, Maring, J K, Heisterkamp, J, van Grevenstein, W M U, Vriens, M R, Besselink, M G H, Borel Rinkes, I H M, Witkamp, A J, Slooter, G D, Konsten, J L M, Engel, A F, Pierik, E G J M, Frakking, T G, van Geldere, D, Patijn, G A, D'Hoore, A J L, de Buck van Overstraeten, A, Miserez, M, Terrasson, I, Wolthuis, A, De Blasiis, M G, Vennix, Sandra, Musters, Gijsbert D, Mulder, Irene M, Swank, Hilko A, Consten, Esther C, Belgers, Eric H, van Geloven, Anna A, Gerhards, Michael F, Govaert, Marc J, van Grevenstein, Wilhelmina M, Hoofwijk, Anton G, Kruyt, Philip M, Nienhuijs, Simon W, Boermeester, Marja A, Vermeulen, Jefrey, van Dieren, Susan, Lange, Johan F, and Bemelman, Willem A

Published
2015
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28. Long-term stoma-related reinterventions after anterior resection for rectal cancer with or without anastomosis: population data from the Dutch snapshot study

Author

Hazen, S. J. A., Vogel, I., Borstlap, W. A. A., Dekker, J. W. T., Tuynman, J. B., Tanis, P. J., Kusters, M., Deijen, C. L., den Dulk, M., Bonjer, H. J., van de Velde, C. J., Aalbers, A. G. J., Acherman, Y., Algie, G. D., von Geusau, B. Alting, Amelung, F., Aukema, T. S., Bakker, I. S., Bartels, S. A., Basha, S., Bastiaansen, A. J. N. M., Belgers, E., Bleeker, W., Blok, J., Bosker, R. J. I., Bosmans, J. W., Boute, M. C., Bouvy, N. D., Bouwman, H., Brandt-Kerkhof, A., Brinkman, D. J., Bruin, S., Bruns, E. R. J., Burbach, J. P. M., Burger, J. W. A., Buskens, C. J., de Mik, S. M. L., van Duijvendijk, P., Gooszen, J. A. H., Hoogland, P., Lamme, B., Marres, C. C., Musters, G. D., van Rossem, C. C., Schreuder, A. M., Swank, H. A., van beek, S. C., van Westreenen, H. L., Westerduin, E., Surgery, CCA - Imaging and biomarkers, CCA - Cancer Treatment and quality of life, Amsterdam Gastroenterology Endocrinology Metabolism, APH - Global Health, APH - Quality of Care, CCA - Cancer biology and immunology, Anatomy and neurosciences, General practice, Obstetrics and gynaecology, VU University medical center, Amsterdam Reproduction & Development (AR&D), Graduate School, CCA - Cancer Treatment and Quality of Life, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism

Subjects
medicine.medical_specialty, Colorectal cancer, Anastomosis, medicine.medical_treatment, digestive system, Stoma, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], medicine, Rectal cancer, business.industry, Gastroenterology, Colostomy, Permanent stoma, Anterior resection, medicine.disease, digestive system diseases, Colorectal surgery, Surgery, medicine.anatomical_structure, surgical procedures, operative, Sphincter, Hartmann’s procedure, business, Cohort study, Abdominal surgery
Abstract

Item does not contain fulltext BACKGROUND: The aim of this study was to analyze the stoma-related reinterventions, complications and readmissions after an anterior resection for rectal cancer, based on a cross-sectional nationwide cohort study with 3-year follow-up. METHODS: Rectal cancer patients who underwent a resection with either a functional anastomosis, a defunctioned anastomosis, or Hartmann's procedure (HP) with an end colostomy in 2011 in 71 Dutch hospitals were included. The primary outcome was number of stoma-related reinterventions. RESULTS: Of the 2095 patients with rectal cancer, 1400 patients received an anterior resection and were included in this study; 257 received an initially functional anastomosis, 741 a defunctioned anastomosis, and 402 patients a HP. Of the 1400 included patients, 62% were males, 38% were females and the mean age was 67 years (SD 11.1). Following a primary functional anastomosis, 48 (19%) patients received a secondary stoma. Stoma-related complications occurred in six (2%) patients, requiring reintervention in one (0.4%) case. In the defunctioned anastomosis group, stoma-related complications were present in 92 (12%) patients, and required reintervention in 23 (3%) patients, in 10 (1%) of these more than 1 year after initial resection. Stoma-related complications occurred in 92 (23%) patients after a HP, and required reintervention in 39 (10%) patients in 17 (4%) of cases more than 1 year after initial resection. The permanent stoma rate was 11% and 20%, in the functional anastomosis and the defuctioned anastomosis group, respectively. The end colostomy in the HP group was reversed in 4% of cases. CONCLUSIONS: Construction of a stoma after resection for rectal cancer with preservation of the sphincter is accompanied with long-term stoma-related morbidity. Stoma complications are more frequent after a HP. Even after 1 year, a significant number of reinterventions are required.

Published
2022
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42. Does oncological outcome differ between restorative and nonrestorative low anterior resection in patients with primary rectal cancer?

Author

Roodbeen, Sapho X., Blok, Robin D., Borstlap, Wernard A., Bemelman, Willem A., Hompes, Roel, Tanis, Pieter J., Aalbers, A. G. J., Acherman, Y., Algie, G. D., Alting von Geusau, B., Amelung, F., Aukema, T. S., Bakker, I. S., Bartels, S. A., Basha, S., Bastiaansen, A. J. N. M., Belgers, E., Bleeker, W., Blok, J., Bosker, R. J. I., Bosmans, J. W., Boute, M. C., Bouvy, N. D., Bouwman, H., Brandt-Kerkhof, A., Brinkman, D. J., Bruin, S., Bruns, E. R. J., Burbach, J. P. M., Burger, J. W. A., Buskens, C. J., Clermonts, S., Coene, P. P. L. O., Compaan, C., Consten, E. C. J., Darbyshire, T., de Mik, S. M. L., van Duijvendijk, P., Gooszen, J. A. H., Hoogland, P., Lamme, B., Marres, C. C., Musters, G. D., van Rossem, C. C., Schreuder, A. M., Swank, H. A., Tuynman, J. B., van Beek, S. C., van Westreenen, H. L., Westerduin, E., ​Robotics and image-guided minimally-invasive surgery (ROBOTICS), Graduate School, CCA - Cancer Treatment and Quality of Life, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Center of Experimental and Molecular Medicine, Surgery, 02 Surgical specialisms, Tytgat Institute for Liver and Intestinal Research, APH - Personalized Medicine, and APH - Quality of Care

Subjects
medicine.medical_specialty, SURGERY, Colorectal cancer, MULTICENTER, Urology, Anastomosis, MESORECTAL EXCISION, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 03 medical and health sciences, 0302 clinical medicine, rectal surgery, Medicine, In patient, Survival analysis, Low Anterior Resection, Neoplasia, oncological outcome, business.industry, Proportional hazards model, Gastroenterology, Original Articles, low anterior resection, medicine.disease, Dissection, 030220 oncology & carcinogenesis, Original Article, 030211 gastroenterology & hepatology, local recurrence, Outcome data, business, RADIOTHERAPY
Abstract

Contains fulltext : 239366.pdf (Publisher’s version ) (Open Access) AIM: Nonrestorative low anterior resection (n-rLAR) (also known as low Hartmann's) is performed for rectal cancer when a poor functional outcome is anticipated or there have been problems when constructing the anastomosis. Compared with restorative LAR (rLAR), little oncological outcome data are available for n-rLAR. The aim of this study was to compare oncological outcomes between rLAR and n-rLAR for primary rectal cancer. METHOD: This was a nationwide cross-sectional comparative study including all elective sphincter-saving LAR procedures for nonmetastatic primary rectal cancer performed in 2011 in 71 Dutch hospitals. Oncological outcomes of patients undergoing rLAR and n-rLAR were collected in 2015; the data were evaluated using Kaplan-Meier survival analysis and the results compared using log-rank testing. Uni- and multivariable Cox regression analysis was used to evaluate the association between the type of LAR and oncological outcome measures. RESULTS: A total of 1197 patients were analysed, of whom 892 (75%) underwent rLAR and 305 (25%) underwent n-rLAR. The 3-year local recurrence (LR) rate was 3% after rLAR and 8% after n-rLAR (P

Published
2020
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45. Prognostic importance of lymph node count and ratio in rectal cancer after neoadjuvant chemoradiotherapy: Results from a cross-sectional study

Author

Detering, Robin, Meyer, Vincent M., Borstlap, Wernard A. A., Beets-Tan, Regina G. H., Marijnen, Corrie A. M., Hompes, Roel, Tanis, Pieter J., van Westreenen, Henderik L., Aalbers, A. G. J., Acherman, Y., Algie, G. D., Alting von Geusau, B., Amelung, F., Aukema, T. S., Bakker, I. S., Bartels, S. A., Basha, S., Bastiaansen, A. J. N. M., Belgers, E., Bleeker, W., Blok, J., Bosker, R. J. I., Bosmans, J. W., Boute, M. C., Bouvy, N. D., Bouwman, H., Brandt-Kerkhof, A., Brinkman, D. J., Bruin, S., Bruns, E. R. J., Burbach, J. P. M., Burger, J. W. A., Buskens, C. J., Clermonts, S., Coene, P. P. L. O., Compaan, C., de Mik, S. M. L., van Duijvendijk, P., Gooszen, J. A. H., Hoogland, P., Lamme, B., Marres, C. C., Musters, G. D., van Rossem, C. C., Schreuder, A. M., Swank, H. A., Tuynman, J. B., van Beek, S. C., van Westreenen, H. L., Westerduin, E., Surgery, CCA - Cancer Treatment and Quality of Life, Amsterdam Gastroenterology Endocrinology Metabolism, Graduate School, AGEM - Endocrinology, metabolism and nutrition, CCA - Cancer Treatment and quality of life, Anatomy and neurosciences, General practice, VU University medical center, Obstetrics and gynaecology, and Amsterdam Reproduction & Development (AR&D)

Subjects
Oncology, medicine.medical_specialty, disease-free survival, Colorectal cancer, Cross-sectional study, survival, chemoradiotherapy, 03 medical and health sciences, 0302 clinical medicine, lymph nodes, Internal medicine, Medicine, Humans, Stage (cooking), rectal cancer, Lymph node, Neoplasm Staging, Netherlands, Retrospective Studies, business.industry, Rectal Neoplasms, General Medicine, medicine.disease, Prognosis, Total mesorectal excision, Neoadjuvant Therapy, Survival Rate, medicine.anatomical_structure, Cross-Sectional Studies, 030220 oncology & carcinogenesis, Lymphatic Metastasis, Cohort, Multivariate Analysis, 030211 gastroenterology & hepatology, Surgery, business, Chemoradiotherapy, Neoadjuvant chemoradiotherapy
Abstract

Background: The aim of this study was to determine the prognostic value of lymph node count (LNC) and lymph node ratio (LNR) in rectal cancer after neoadjuvant chemoradiotherapy (CRT). Methods: Patients who underwent neoadjuvant CRT and total mesorectal excision (TME) for Stage I–III rectal cancer were selected from a cross-sectional study including 71 Dutch centres. Primary outcome parameters were disease-free survival (DFS) and overall survival (OS). Prognostic significance of LNC and LNR (cut-off values 0.15, 0.20, 0.30) was tested for different (sub)groups. Results: From 2095 registered patients, 458 were included, of which 240 patients with LNC < 12 and 218 patients with LNC ≥ 12. LNC was not significantly associated with DFS (p = 0.35) and OS (p = 0.59). In univariable analysis, LNR was significantly associated with DFS and OS in the whole cohort and LNC subgroups, but not in multivariable analysis. Conclusions: LNC was not associated with long-term oncological outcome in rectal cancer patients treated with CRT, nor was LNR when corrected for N-stage. However, LNR might be used to identify subgroups of node-positive patients with a favourable outcome.

Published
2021
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49. CD127+ CD94+ innate lymphoid cells expressing granulysin and perforin are expanded in patients with Crohn’s disease

Author

Afd Chemical Biology and Drug Discovery, Chemical Biology and Drug Discovery, Krabbendam, L., Heesters, B. A., Kradolfer, C. M.A., Haverkate, N. J.E., Becker, M. A.J., Buskens, C. J., Bemelman, W. A., Bernink, J. H., Spits, H., Afd Chemical Biology and Drug Discovery, Chemical Biology and Drug Discovery, Krabbendam, L., Heesters, B. A., Kradolfer, C. M.A., Haverkate, N. J.E., Becker, M. A.J., Buskens, C. J., Bemelman, W. A., Bernink, J. H., and Spits, H.

Published
2021

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