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493 results on '"Buscarini, E."'

1. The interaction of patients’ physical status and time to endoscopy on mortality risk in patients with upper gastrointestinal bleeding: A national prospective cohort study

Author

Amitrano, L, Anderloni, A, Andriulli, A, Annese, V, Baldassarre, G, Bargiggia, S, Balzano, A, Bazzoli, F, Bennato, R, Bianco, M A, Bizzotto, A, Boarino, V, Bonanomi, AG, Borgheresi, P, Bresci, G, Buffoli, F, Buscarini, E, Castrignanò, G, Cavallaro, LG, Cesaro, P, Chirico, A, Cipolletta, F, Cipolletta, L, Conigliaro, R, Conte, D, Costamagna, G, Covello, F, D'Amico, G, De Fanis, C, De Filippo, FR, de Franchis, R, Dell‘Era, A, De Nigris, F, De Matthaeis, M, Di Giorgio, P, Di Giulio, E, Esposito, P, Ferraris, L, Filippino, A, Franceschi, M, Furio, L, Germana’, B, Grassia, R, Imperiali, G, Lamanda, R, Lauri, A, Londoni, C, Mangiafico, S, Manno, M, Marmo, C, Merighi, A, Meroni, R, Metrangolo, S, Montalbano, L M, Napolitano, G, Nucci, A, Orsini, L, Parente, F, Parravicini, M, Paterlini, A, Pumpo, R, Purita, L, Repici, A, Riccioni, ME, Russo, A, Segato, S, Sorrentino, I, Spinzi, G, Spotti, D, Tortora, A, Tomba, C, Triossi, O, Zagari, RM, Zambelli, A, Bucci, Cristina, Marmo, Clelia, Soncini, Marco, Riccioni, Maria Elena, Laursen, Stig B., Gralnek, Ian M., and Marmo, Riccardo

Published
2024
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2. The European Rare Disease Network for HHT Frameworks for management of hereditary haemorrhagic telangiectasia in general and speciality care

Author

Shovlin, C.L., Buscarini, E., Sabbà, C., Mager, H.J., Kjeldsen, A.D., Pagella, F., Sure, U., Ugolini, S., Torring, P.M., Suppressa, P., Rennie, C., Post, M.C., Patel, M.C., Nielsen, T.H., Manfredi, G., Lenato, G.M., Lefroy, D., Kariholu, U., Jones, B., Fialla, A.D., Eker, O.F., Dupuis, O., Droege, F., Coote, N., Boccardi, E., Alsafi, A., Alicante, S., and Dupuis-Girod, S.

Published
2022
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3. Combining a Computer Aided Detection system (CADe) and G-EYE balloon for adenoma detection in a FIT-based organized colorectal cancer screening program: preliminary results of a randomized controlled trial

Author

Rocchetto, S., additional, Segatta, F., additional, Piagnani, A., additional, Paggi, S., additional, Bina, N., additional, Di Paolo, D., additional, Scardino, G., additional, Terreni, N., additional, Mandelli, G., additional, Buscarini, E., additional, Romeo, S., additional, Alicante, S., additional, Buda, A., additional, Rizzotto, E. Rosa, additional, Di Mitri, R., additional, Hassan, C., additional, Repici, A., additional, Rondonotti, E., additional, and Radaelli, F., additional

Published
2024
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4. The "Hub and Spoke" model has no effect on mortality in acute upper gastrointestinal bleeding: A prospective multicenter cohort study

Author

Amitrano, L, Anderloni, A, Andriulli, A, Annese, V, Baldassarre, G, Bargiggia, S, Bazzoli, F, Bennato, R, Bianco, MA, Bizzotto, A, Boarino, V, Bonanomi, AG, Borgheresi, P, Bresci, G, Buffoli, F, Buscarini, E, Castrignanò, G, Cavallaro, LG, Cesaro, P, Chirico, A, Cipolletta, F, Cipolletta, L, Conigliaro, R, Conte, D, Costamagna, G, Covello, F, D'Amico, G, De-Fanis, C, De-Filippo, FR, de-Franchis, R, Dell‘Era, A, De Nigris, F, De-Matthaeis, M, Di-Giorgio, P, Di-Giulio, E, Esposito, P, Ferraris, L, Filippino, A, Franceschi, M, Furio, L, Germana', B, Grassia, R, Imperiali, G, Lamanda, R, Lauri, A, Londoni, C, Mangiafico, S, Manno, M, Marmo, C, Merighi, A, Meroni, R., Metrangolo, S, Montalbano, LM, Napolitano, G, Nucci, A, Orsini, L, Parente, F, Parravicini, M, Paterlini, A, Pumpo, R, Purita, L, Repici, A, Riccioni, ME, Russo, A, Segato, S, Sorrentino, I, Spinzi, G, Spotti, D, Tortora, A, Tomba, C, Triossi, O, Zagari, RM, Zambelli, A, Marmo, Riccardo, Soncini, Marco, Bucci, Cristina, and Zullo, Angelo

Published
2021
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5. Dysmetabolism, Diabetes and Clinical Outcomes in Patients Cured of Chronic Hepatitis C: A Real-Life Cohort Study

Author

Valenti, L, Pelusi, S, Aghemo, A, Gritti, S, Pasulo, L, Bianco, C, Iegri, C, Cologni, G, Degasperi, E, D'Ambrosio, R, del Poggio, P, Soria, A, Puoti, M, Carderi, I, Pigozzi, M, Carriero, C, Spinetti, A, Zuccaro, V, Memoli, M, Giorgini, A, Vigano, M, Rumi, M, Re, T, Spinelli, O, Colombo, M, Quirino, T, Menzaghi, B, Lorini, G, Pan, A, D'Arminio Monforte, A, Buscarini, E, Autolitano, A, Bonfanti, P, Terreni, N, Aimo, G, Mendeni, M, Prati, D, Lampertico, P, Fagiuoli, S, Valenti L., Pelusi S., Aghemo A., Gritti S., Pasulo L., Bianco C., Iegri C., Cologni G., Degasperi E., D'Ambrosio R., del Poggio P., Soria A., Puoti M., Carderi I., Pigozzi M. G., Carriero C., Spinetti A., Zuccaro V., Memoli M., Giorgini A., Vigano M., Rumi M. G., Re T., Spinelli O., Colombo M. C., Quirino T., Menzaghi B., Lorini G., Pan A., D'Arminio Monforte A., Buscarini E., Autolitano A., Bonfanti P., Terreni N., Aimo G., Mendeni M., Prati D., Lampertico P., Colombo M., Fagiuoli S., Valenti, L, Pelusi, S, Aghemo, A, Gritti, S, Pasulo, L, Bianco, C, Iegri, C, Cologni, G, Degasperi, E, D'Ambrosio, R, del Poggio, P, Soria, A, Puoti, M, Carderi, I, Pigozzi, M, Carriero, C, Spinetti, A, Zuccaro, V, Memoli, M, Giorgini, A, Vigano, M, Rumi, M, Re, T, Spinelli, O, Colombo, M, Quirino, T, Menzaghi, B, Lorini, G, Pan, A, D'Arminio Monforte, A, Buscarini, E, Autolitano, A, Bonfanti, P, Terreni, N, Aimo, G, Mendeni, M, Prati, D, Lampertico, P, Fagiuoli, S, Valenti L., Pelusi S., Aghemo A., Gritti S., Pasulo L., Bianco C., Iegri C., Cologni G., Degasperi E., D'Ambrosio R., del Poggio P., Soria A., Puoti M., Carderi I., Pigozzi M. G., Carriero C., Spinetti A., Zuccaro V., Memoli M., Giorgini A., Vigano M., Rumi M. G., Re T., Spinelli O., Colombo M. C., Quirino T., Menzaghi B., Lorini G., Pan A., D'Arminio Monforte A., Buscarini E., Autolitano A., Bonfanti P., Terreni N., Aimo G., Mendeni M., Prati D., Lampertico P., Colombo M., and Fagiuoli S.

Abstract

The aim of this study was to examine the impact of features of dysmetabolism on liver disease severity, evolution, and clinical outcomes in a real-life cohort of patients treated with direct acting antivirals for chronic hepatitis C virus (HCV) infection. To this end, we considered 7,007 patients treated between 2014 and 2018, 65.3% with advanced fibrosis, of whom 97.7% achieved viral eradication (NAVIGATORE-Lombardia registry). In a subset (n = 748), liver stiffness measurement (LSM) was available at baseline and follow-up. Higher body mass index (BMI; odds ratio [OR] 1.06 per kg/m2, 1.03-1.09) and diabetes (OR 2.01 [1.65-2.46]) were independently associated with advanced fibrosis at baseline, whereas statin use was protective (OR 0.46 [0.35-0.60]; P < 0.0001 for all). The impact of BMI was greater in those without diabetes (P = 0.003). Diabetes was independently associated with less pronounced LSM improvement after viral eradication (P = 0.001) and in patients with advanced fibrosis was an independent predictor of the most frequent clinical events, namely de novo hepatocellular carcinoma (HCC; hazard ratio [HR] 2.09 [1.20-3.63]; P = 0.009) and cardiovascular events (HR 2.73 [1.16-6.43]; P = 0.021). Metformin showed a protective association against HCC (HR 0.32 [0.11-0.96]; P = 0.043), which was confirmed after adjustment for propensity score (P = 0.038). Diabetes diagnosis further refined HCC prediction in patients with compensated advanced chronic liver disease at high baseline risk (P = 0.024). Conclusion: Metabolic comorbidities were associated with advanced liver fibrosis at baseline, whereas statins were protective. In patients with advanced fibrosis, diabetes increased the risk of de novo HCC and of cardiovascular events. Optimization of metabolic comorbidities treatment by a multi-disciplinary management approach may improve cardiovascular and possibly liver-related

Published
2022

9. High rates of sustained virological response despite premature discontinuation of directly acting antivirals in HCV-infected patients treated in a real-life setting

Author

Fabbiani, M, Lombardi, A, Colaneri, M, Del Poggio, P, Perini, P, D'Ambrosio, R, Degasperi, E, Dibenedetto, C, Giorgini, A, Pasulo, L, Maggiolo, F, Castelli, F, Brambilla, P, Spinelli, O, Re, T, Lleo, A, Rumi, M, Uberti-Foppa, C, Soria, A, Aghemo, A, Lampertico, P, Baiguera, C, Schiavini, M, Fagiuoli, S, Bruno, R, Borghi, M, Soffredini, R, Perbellini, R, Gori, A, Ferroni, V, Colpani, M, Manini, M, Cologni, G, Lazzaroni, S, Vinci, M, De Nicola, S, Mazzarelli, C, Angelini Zucchetti, T, Picciotto, V, Puoti, M, Rossotti, R, Landonio, S, Magni, C, Rizzardini, G, Colella, E, Columpsi, P, Gambaro, A, Spolti, A, Magnani, C, Vigano, P, Mena, M, Villa, M, Caramma, I, Basilico, C, Capelli, F, Biagiotti, S, Mazzone, A, Saladino, V, Baldacci, M, Gatti, F, Varalli, L, Morini, L, Menzaghi, B, Farinazzo, M, Meli, R, Plaz Torres, M, Fanetti, I, Orellana, D, Zermiani, P, Zuin, M, De Bona, A, D'Arminio Monforte, A, Capretti, A, Taddei, M, Soncini, M, Spinetti, A, Zaltron, S, Pigozzi, M, Rossini, A, Pan, A, Dal Zoppo, S, Zoncada, A, Memoli, M, Salpietro, S, Hamid, H, Messina, E, Colombo, A, Giglio, O, Bonfanti, P, Molteni, C, Terreni, N, Spinzi, G, Conforti, S, Clerici, E, Menozzi, F, Buscarini, E, Centenaro, R, Corbellini, A, Noventa, F, Gritti, S, Giani, P, Fabbiani M., Lombardi A., Colaneri M., Del Poggio P., Perini P., D'Ambrosio R., Degasperi E., Dibenedetto C., Giorgini A., Pasulo L., Maggiolo F., Castelli F., Brambilla P., Spinelli O., Re T., Lleo A., Rumi M., Uberti-Foppa C., Soria A., Aghemo A., Lampertico P., Baiguera C., Schiavini M., Fagiuoli S., Bruno R., Borghi M., Soffredini R., Perbellini R., Gori A., Ferroni V., Colpani M., Manini M., Cologni G., Lazzaroni S., Vinci M., De Nicola S., Mazzarelli C., Angelini Zucchetti T., Picciotto V., Puoti M., Rossotti R., Landonio S., Magni C. F., Rizzardini G., Colella E., Columpsi P., Gambaro A., Spolti A., Magnani C., Vigano P., Mena M., Villa M., Caramma I., Basilico C., Capelli F., Biagiotti S., Mazzone A., Saladino V., Baldacci M. P., Gatti F., Varalli L., Morini L., Menzaghi B., Farinazzo M., Meli R., Plaz Torres M. C., Fanetti I., Orellana D., Zermiani P., Zuin M., De Bona A., D'Arminio Monforte A., Capretti A., Taddei M. T., Soncini M., Spinetti A., Zaltron S., Pigozzi M. G., Rossini A., Pan A., Dal Zoppo S., Zoncada A., Memoli M., Salpietro S., Hamid H., Messina E., Colombo A. E., Giglio O., Bonfanti P., Molteni C., Terreni N., Spinzi G., Conforti S., Clerici E., Menozzi F., Buscarini E., Centenaro R., Corbellini A., Noventa F., Gritti S., Giani P., Fabbiani, M, Lombardi, A, Colaneri, M, Del Poggio, P, Perini, P, D'Ambrosio, R, Degasperi, E, Dibenedetto, C, Giorgini, A, Pasulo, L, Maggiolo, F, Castelli, F, Brambilla, P, Spinelli, O, Re, T, Lleo, A, Rumi, M, Uberti-Foppa, C, Soria, A, Aghemo, A, Lampertico, P, Baiguera, C, Schiavini, M, Fagiuoli, S, Bruno, R, Borghi, M, Soffredini, R, Perbellini, R, Gori, A, Ferroni, V, Colpani, M, Manini, M, Cologni, G, Lazzaroni, S, Vinci, M, De Nicola, S, Mazzarelli, C, Angelini Zucchetti, T, Picciotto, V, Puoti, M, Rossotti, R, Landonio, S, Magni, C, Rizzardini, G, Colella, E, Columpsi, P, Gambaro, A, Spolti, A, Magnani, C, Vigano, P, Mena, M, Villa, M, Caramma, I, Basilico, C, Capelli, F, Biagiotti, S, Mazzone, A, Saladino, V, Baldacci, M, Gatti, F, Varalli, L, Morini, L, Menzaghi, B, Farinazzo, M, Meli, R, Plaz Torres, M, Fanetti, I, Orellana, D, Zermiani, P, Zuin, M, De Bona, A, D'Arminio Monforte, A, Capretti, A, Taddei, M, Soncini, M, Spinetti, A, Zaltron, S, Pigozzi, M, Rossini, A, Pan, A, Dal Zoppo, S, Zoncada, A, Memoli, M, Salpietro, S, Hamid, H, Messina, E, Colombo, A, Giglio, O, Bonfanti, P, Molteni, C, Terreni, N, Spinzi, G, Conforti, S, Clerici, E, Menozzi, F, Buscarini, E, Centenaro, R, Corbellini, A, Noventa, F, Gritti, S, Giani, P, Fabbiani M., Lombardi A., Colaneri M., Del Poggio P., Perini P., D'Ambrosio R., Degasperi E., Dibenedetto C., Giorgini A., Pasulo L., Maggiolo F., Castelli F., Brambilla P., Spinelli O., Re T., Lleo A., Rumi M., Uberti-Foppa C., Soria A., Aghemo A., Lampertico P., Baiguera C., Schiavini M., Fagiuoli S., Bruno R., Borghi M., Soffredini R., Perbellini R., Gori A., Ferroni V., Colpani M., Manini M., Cologni G., Lazzaroni S., Vinci M., De Nicola S., Mazzarelli C., Angelini Zucchetti T., Picciotto V., Puoti M., Rossotti R., Landonio S., Magni C. F., Rizzardini G., Colella E., Columpsi P., Gambaro A., Spolti A., Magnani C., Vigano P., Mena M., Villa M., Caramma I., Basilico C., Capelli F., Biagiotti S., Mazzone A., Saladino V., Baldacci M. P., Gatti F., Varalli L., Morini L., Menzaghi B., Farinazzo M., Meli R., Plaz Torres M. C., Fanetti I., Orellana D., Zermiani P., Zuin M., De Bona A., D'Arminio Monforte A., Capretti A., Taddei M. T., Soncini M., Spinetti A., Zaltron S., Pigozzi M. G., Rossini A., Pan A., Dal Zoppo S., Zoncada A., Memoli M., Salpietro S., Hamid H., Messina E., Colombo A. E., Giglio O., Bonfanti P., Molteni C., Terreni N., Spinzi G., Conforti S., Clerici E., Menozzi F., Buscarini E., Centenaro R., Corbellini A., Noventa F., Gritti S., and Giani P.

Abstract

In routine clinical practice, hepatitis C virus-infected patients can prematurely discontinue the prescribed regimen for several reasons. The aim of our study was to investigate sustained virological response (SVR12) rates in patients who prematurely discontinued directly acting antiviral (DAA) regimens and to assess the shortest effective duration of DAA able to lead to SVR12. We retrospectively collected the SVR rates of patients, registered in the NAVIGATORE-Lombardia Network database from January 2015, who discontinued DAAs before the predefined end of treatment. Overall, we included 365 patients, males were the majority (213, 58.4%), mean age was 60.5 years, and 53 (14.5%) patients were HIV-co-infected. Liver cirrhosis was observed in 251 (68.8%) subjects, and the most represented genotypes were 1b (n = 168, 46%) and 3 (n = 59, 16.2%). DAA was discontinued a median of 1 (IQR 1–4) weeks before the predefined EOT, with 164 (44.9%) patients stopping DAAs at least 2 weeks before the planned schedule. In patients with F0–F3 liver fibrosis, lower rates of SVR12 were observed in patients treated for <4 weeks: 50% (n = 2/4) vs. 99.1% (n = 109/110) for ≥4 weeks, p = 0.003. In patients with liver cirrhosis, lower rates of SVR12 were observed in patients treated <8 weeks: 83.3% (n = 25/30) vs. 94.6% (n = 209/221) for ≥8 weeks, p = 0.038. Despite premature discontinuation of DAA, high SVR12 rates were observed in a real-life setting for treatment lasting at least 4 weeks in patients with liver fibrosis F0–F3 and 8 weeks in those with liver cirrhosis. On this basis, feasibility of reducing DAA treatment duration should be explored in randomized clinical trials.

Published
2021

10. Renal safety in 3264 HCV patients treated with DAA-based regimens: Results from a large Italian real-life study

Author

D'Ambrosio, R, Pasulo, L, Giorgini, A, Spinetti, A, Messina, E, Fanetti, I, Puoti, M, Aghemo, A, Vigano, P, Vinci, M, Menzaghi, B, Lombardi, A, Pan, A, Pigozzi, M, Grossi, P, Lazzaroni, S, Spinelli, O, Invernizzi, P, Maggiolo, F, Terreni, N, Monforte, A, Poggio, P, Taddei, M, Colombo, S, Pozzoni, P, Molteni, C, Brocchieri, A, Bhoori, S, Buscarini, E, Centenaro, R, Mendeni, M, Colombo, A, Di Marco, M, Dionigi, E, Bella, D, Borghi, M, Zuin, M, Zaltron, S, Noventa, F, Annalisa, D, Lampertico, P, Fagiuoli, S, D'Ambrosio R., Pasulo L., Giorgini A., Spinetti A., Messina E., Fanetti I., Puoti M., Aghemo A., Vigano P., Vinci M., Menzaghi B., Lombardi A., Pan A., Pigozzi M. G., Grossi P., Lazzaroni S., Spinelli O., Invernizzi P., Maggiolo F., Terreni N., Monforte A. D., Poggio P. D., Taddei M. T., Colombo S., Pozzoni P., Molteni C., Brocchieri A., Bhoori S., Buscarini E., Centenaro R., Mendeni M., Colombo A. E., Di Marco M., Dionigi E., Bella D., Borghi M., Zuin M., Zaltron S., Noventa F., Annalisa D. S., Lampertico P., Fagiuoli S., D'Ambrosio, R, Pasulo, L, Giorgini, A, Spinetti, A, Messina, E, Fanetti, I, Puoti, M, Aghemo, A, Vigano, P, Vinci, M, Menzaghi, B, Lombardi, A, Pan, A, Pigozzi, M, Grossi, P, Lazzaroni, S, Spinelli, O, Invernizzi, P, Maggiolo, F, Terreni, N, Monforte, A, Poggio, P, Taddei, M, Colombo, S, Pozzoni, P, Molteni, C, Brocchieri, A, Bhoori, S, Buscarini, E, Centenaro, R, Mendeni, M, Colombo, A, Di Marco, M, Dionigi, E, Bella, D, Borghi, M, Zuin, M, Zaltron, S, Noventa, F, Annalisa, D, Lampertico, P, Fagiuoli, S, D'Ambrosio R., Pasulo L., Giorgini A., Spinetti A., Messina E., Fanetti I., Puoti M., Aghemo A., Vigano P., Vinci M., Menzaghi B., Lombardi A., Pan A., Pigozzi M. G., Grossi P., Lazzaroni S., Spinelli O., Invernizzi P., Maggiolo F., Terreni N., Monforte A. D., Poggio P. D., Taddei M. T., Colombo S., Pozzoni P., Molteni C., Brocchieri A., Bhoori S., Buscarini E., Centenaro R., Mendeni M., Colombo A. E., Di Marco M., Dionigi E., Bella D., Borghi M., Zuin M., Zaltron S., Noventa F., Annalisa D. S., Lampertico P., and Fagiuoli S.

Abstract

Background: Sofosbuvir (SOF)-based regimens have been associated with renal function worsening in HCV patients with estimated glomerular filtration rate (eGFR) ≤ 45 ml/min, but further investigations are lacking. Aim: To assess renal safety in a large cohort of DAA-treated HCV patients with any chronic kidney disease (CKD). Methods: All HCV patients treated with DAA in Lombardy (December 2014–November 2017) with available kidney function tests during and off-treatment were included. Results: Among 3264 patients [65% males, 67% cirrhotics, eGFR 88 (9–264) ml/min], CKD stage was 3 in 9.5% and 4/5 in 0.7%. 79% and 73% patients received SOF and RBV, respectively. During DAA, eGFR declined in CKD-1 (p < 0.0001) and CKD-2 (p = 0.0002) patients, with corresponding rates of CKD stage reduction of 25% and 8%. Conversely, eGFR improved in lower CKD stages (p < 0.0001 in CKD-3a, p = 0.0007 in CKD-3b, p = 0.024 in CKD-4/5), with 33–45% rates of CKD improvement. Changes in eGFR and CKD distribution persisted at SVR. Baseline independent predictors of CKD worsening at EOT and SVR were age (p < 0.0001), higher baseline CKD stages (p < 0.0001) and AH (p = 0.010 and p < 0.0001, respectively). Conclusions: During DAA, eGFR significantly declined in patients with preserved renal function and improved in those with lower CKD stages, without reverting upon drug discontinuation.

Published
2020

11. Reply to: Correspondence on “High rates of 30-day mortality in patients with cirrhosis and COVID-19”

Author

Iavarone, M, D'Ambrosio, R, Lampertico, P, Rimondi, A, Soria, A, Bonfanti, P, Triolo, M, Fagiuoli, S, Pugliese, N, Aghemo, A, Del Poggio, P, Perricone, G, Belli, L, Massironi, S, Luca, M, Invernizzi, P, Spinetti, A, Carriero, C, Buscarini, E, Pedaci, M, Vigano, M, Rumi, M, Iavarone M., D'Ambrosio R., Lampertico P., Rimondi A., Soria A., Bonfanti P., Triolo M., Fagiuoli S., Pugliese N., Aghemo A., Del Poggio P., Perricone G., Belli L. S., Massironi S., Luca M., Invernizzi P., Spinetti A., Carriero C., Buscarini E., Pedaci M., Vigano M., Rumi M. G., Iavarone, M, D'Ambrosio, R, Lampertico, P, Rimondi, A, Soria, A, Bonfanti, P, Triolo, M, Fagiuoli, S, Pugliese, N, Aghemo, A, Del Poggio, P, Perricone, G, Belli, L, Massironi, S, Luca, M, Invernizzi, P, Spinetti, A, Carriero, C, Buscarini, E, Pedaci, M, Vigano, M, Rumi, M, Iavarone M., D'Ambrosio R., Lampertico P., Rimondi A., Soria A., Bonfanti P., Triolo M., Fagiuoli S., Pugliese N., Aghemo A., Del Poggio P., Perricone G., Belli L. S., Massironi S., Luca M., Invernizzi P., Spinetti A., Carriero C., Buscarini E., Pedaci M., Vigano M., and Rumi M. G.

Published
2020

12. Endoscopic Findings in Patients Infected With 2019 Novel Coronavirus in Lombardy, Italy

Author

Massironi, S, Vigano, C, Dioscoridi, L, Filippi, E, Pagliarulo, M, Manfredi, G, Conti, C, Signorelli, C, Redaelli, A, Bonato, G, Iiritano, E, Frego, R, Zucchini, N, Ungari, M, Pedaci, M, Bono, F, Di Bella, C, Buscarini, E, Mutignani, M, Penagini, R, Dinelli, M, Invernizzi, P, Massironi S., Vigano C., Dioscoridi L., Filippi E., Pagliarulo M., Manfredi G., Conti C. B., Signorelli C., Redaelli A. E., Bonato G., Iiritano E., Frego R., Zucchini N., Ungari M., Pedaci M., Bono F., Di Bella C., Buscarini E., Mutignani M., Penagini R., Dinelli M. E., Invernizzi P., Massironi, S, Vigano, C, Dioscoridi, L, Filippi, E, Pagliarulo, M, Manfredi, G, Conti, C, Signorelli, C, Redaelli, A, Bonato, G, Iiritano, E, Frego, R, Zucchini, N, Ungari, M, Pedaci, M, Bono, F, Di Bella, C, Buscarini, E, Mutignani, M, Penagini, R, Dinelli, M, Invernizzi, P, Massironi S., Vigano C., Dioscoridi L., Filippi E., Pagliarulo M., Manfredi G., Conti C. B., Signorelli C., Redaelli A. E., Bonato G., Iiritano E., Frego R., Zucchini N., Ungari M., Pedaci M., Bono F., Di Bella C., Buscarini E., Mutignani M., Penagini R., Dinelli M. E., and Invernizzi P.

Abstract

Coronavirus disease 2019 (COVID-19) is a major worldwide threat caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), rapidly spreading to a global pandemic. As of May 11, 2020, 4,176,346 cases have been reported worldwide, 219,814 in Italy, and of them, 81,871 occurred in the Lombardy region.1 Although the respiratory manifestations of COVID-19 have been widely described, the impact on the gastrointestinal (GI) system remains less clear. The reported prevalence of digestive symptoms ranges from 3% to 79%, depending on the setting,2–5 but data on GI endoscopic and histologic findings in COVID-19 patients are lacking. Therefore, the aim of this study is to describe the GI endoscopic and histologic findings in COVID-19 patients.

Published
2020

13. The European Rare Disease Network for HHT Frameworks for management of hereditary haemorrhagic telangiectasia in general and speciality care

Author

Verpleegafdeling Cardiologie, Team Medisch, Circulatory Health, Shovlin, C. L., Buscarini, E., Sabbà, C., Mager, H. J., Kjeldsen, A. D., Pagella, F., Sure, U., Ugolini, S., Torring, P. M., Suppressa, P., Rennie, C., Post, M. C., Patel, M. C., Nielsen, T. H., Manfredi, G., Lenato, G. M., Lefroy, D., Kariholu, U., Jones, B., Fialla, A. D., Eker, O. F., Dupuis, O., Droege, F., Coote, N., Boccardi, E., Alsafi, A., Alicante, S., Dupuis-Girod, S., Verpleegafdeling Cardiologie, Team Medisch, Circulatory Health, Shovlin, C. L., Buscarini, E., Sabbà, C., Mager, H. J., Kjeldsen, A. D., Pagella, F., Sure, U., Ugolini, S., Torring, P. M., Suppressa, P., Rennie, C., Post, M. C., Patel, M. C., Nielsen, T. H., Manfredi, G., Lenato, G. M., Lefroy, D., Kariholu, U., Jones, B., Fialla, A. D., Eker, O. F., Dupuis, O., Droege, F., Coote, N., Boccardi, E., Alsafi, A., Alicante, S., and Dupuis-Girod, S.

Published
2022

16. EFFICACY OF A COMPUTER AIDED DETECTION (CADE) SYSTEM IN A FIT-BASED ORGANIZED COLORECTAL CANCER SCREENING PROGRAM: A RANDOMIZED CONTROLLED TRIAL

Author

Di Paolo, D., additional, Rondonotti, E., additional, Paggi, S., additional, Rosa Rizzotto, E., additional, Alvisi, C., additional, Buscarini, E., additional, Spadaccini, M., additional, Tamanini, G., additional, Amato, A., additional, Scardino, G., additional, Mandelli, G., additional, Lenoci, N., additional, Terreni, N., additional, Romeo, S., additional, Alicante, S., additional, Ancona, F., additional, Guido, E., additional, Marzo, V., additional, Chicco, F., additional, Agazzi, S., additional, Repici, A., additional, Ambrosini, L., additional, Filippi, E., additional, Sassatelli, R., additional, Sereni, G., additional, Khalaf, K., additional, Hassan, C., additional, and Radaelli, F., additional

Published
2022
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17. High rates of sustained virological response despite premature discontinuation of directly acting antivirals in HCV-infected patients treated in a real-life setting

Author

Fabbiani M., Lombardi A., Colaneri M., Del Poggio P., Perini P., D'Ambrosio R., Degasperi E., Dibenedetto C., Giorgini A., Pasulo L., Maggiolo F., Castelli F., Brambilla P., Spinelli O., Re T., Lleo A., Rumi M., Uberti-Foppa C., Soria A., Aghemo A., Lampertico P., Baiguera C., Schiavini M., Fagiuoli S., Bruno R., Borghi M., Soffredini R., Perbellini R., Gori A., Ferroni V., Colpani M., Manini M., Cologni G., Lazzaroni S., Vinci M., De Nicola S., Mazzarelli C., Angelini Zucchetti T., Picciotto V., Puoti M., Rossotti R., Landonio S., Magni C. F., Rizzardini G., Colella E., Columpsi P., Gambaro A., Spolti A., Magnani C., Vigano P., Mena M., Villa M., Caramma I., Basilico C., Capelli F., Biagiotti S., Mazzone A., Saladino V., Baldacci M. P., Gatti F., Varalli L., Morini L., Menzaghi B., Farinazzo M., Meli R., Plaz Torres M. C., Fanetti I., Orellana D., Zermiani P., Zuin M., De Bona A., D'Arminio Monforte A., Capretti A., Taddei M. T., Soncini M., Spinetti A., Zaltron S., Pigozzi M. G., Rossini A., Pan A., Dal Zoppo S., Zoncada A., Memoli M., Salpietro S., Hamid H., Messina E., Colombo A. E., Giglio O., Bonfanti P., Molteni C., Terreni N., Spinzi G., Conforti S., Clerici E., Menozzi F., Buscarini E., Centenaro R., Corbellini A., Noventa F., Gritti S., Giani P., Fabbiani, Massimiliano, Lombardi, Andrea, Colaneri, Marta, Del Poggio, Paolo, Perini, Paolo, D'Ambrosio, Roberta, Degasperi, Elisabetta, Dibenedetto, Clara, Giorgini, Alessia, Pasulo, Luisa, Maggiolo, Franco, Castelli, Francesco, Brambilla, Paola, Spinelli, Ombretta, Tiziana, Re, Lleo, Ana, Rumi, Mariagrazia, Uberti-Foppa, Caterina, Soria, Alessandro, Aghemo, Alessio, Lampertico, Pietro, Baiguera, Chiara, Schiavini, Monica, Fagiuoli, Stefano, Bruno, Raffaele, Fabbiani, M, Lombardi, A, Colaneri, M, Del Poggio, P, Perini, P, D'Ambrosio, R, Degasperi, E, Dibenedetto, C, Giorgini, A, Pasulo, L, Maggiolo, F, Castelli, F, Brambilla, P, Spinelli, O, Re, T, Lleo, A, Rumi, M, Uberti-Foppa, C, Soria, A, Aghemo, A, Lampertico, P, Baiguera, C, Schiavini, M, Fagiuoli, S, Bruno, R, Borghi, M, Soffredini, R, Perbellini, R, Gori, A, Ferroni, V, Colpani, M, Manini, M, Cologni, G, Lazzaroni, S, Vinci, M, De Nicola, S, Mazzarelli, C, Angelini Zucchetti, T, Picciotto, V, Puoti, M, Rossotti, R, Landonio, S, Magni, C, Rizzardini, G, Colella, E, Columpsi, P, Gambaro, A, Spolti, A, Magnani, C, Vigano, P, Mena, M, Villa, M, Caramma, I, Basilico, C, Capelli, F, Biagiotti, S, Mazzone, A, Saladino, V, Baldacci, M, Gatti, F, Varalli, L, Morini, L, Menzaghi, B, Farinazzo, M, Meli, R, Plaz Torres, M, Fanetti, I, Orellana, D, Zermiani, P, Zuin, M, De Bona, A, D'Arminio Monforte, A, Capretti, A, Taddei, M, Soncini, M, Spinetti, A, Zaltron, S, Pigozzi, M, Rossini, A, Pan, A, Dal Zoppo, S, Zoncada, A, Memoli, M, Salpietro, S, Hamid, H, Messina, E, Colombo, A, Giglio, O, Bonfanti, P, Molteni, C, Terreni, N, Spinzi, G, Conforti, S, Clerici, E, Menozzi, F, Buscarini, E, Centenaro, R, Corbellini, A, Noventa, F, Gritti, S, and Giani, P

Subjects
Simeprevir, Male, medicine.medical_specialty, Cirrhosis, SVR, Sofosbuvir, Sustained Virologic Response, liver cirrhosis, antiviral treatment, Hepacivirus, Antiviral Agents, law.invention, Randomized controlled trial, law, Virology, Internal medicine, Medicine, Humans, chronic hepatitis C, Prospective cohort study, DAA, Retrospective Studies, Hepatology, liver cirrhosi, business.industry, Hepatitis C, Hepatitis C, Chronic, Middle Aged, medicine.disease, Discontinuation, Regimen, Infectious Diseases, Treatment Outcome, business, medicine.drug
Abstract

In routine clinical practice, hepatitis C virus-infected patients can prematurely discontinue the prescribed regimen for several reasons. The aim of our study was to investigate sustained virological response (SVR12) rates in patients who prematurely discontinued directly acting antiviral (DAA) regimens and to assess the shortest effective duration of DAA able to lead to SVR12. We retrospectively collected the SVR rates of patients, registered in the NAVIGATORE-Lombardia Network database from January 2015, who discontinued DAAs before the predefined end of treatment. Overall, we included 365 patients, males were the majority (213, 58.4%), mean age was 60.5years, and 53 (14.5%) patients were HIV-co-infected. Liver cirrhosis was observed in 251 (68.8%) subjects, and the most represented genotypes were 1b (n=168, 46%) and 3 (n=59, 16.2%). DAA was discontinued a median of 1 (IQR 1–4) weeks before the predefined EOT, with 164 (44.9%) patients stopping DAAs at least 2weeks before the planned schedule. In patients with F0–F3 liver fibrosis, lower rates of SVR12 were observed in patients treated for

Published
2021

18. Derivation and validation of Re.Co.De death score risk in patients with acute nonvariceal upper GI bleeding

Author

Riccardo Marmo, Marco Soncini, Cristina Bucci, Vincenzo Occhipinti, Lucienne Pellegrini, Angelo Zullo, Amitrano L, Andriulli A, Annese V, Baldassarre G, Bargiggia S, Balzano A, Bazzoli F, Bennato R, Bianco M A, Bizzotto A, Boarino V, Bonanomi AG, Borgheresi P, Bresci G, Buffoli F, Buscarini E, Castrignanò G, Cavallaro LG, Cesaro P, Chirico A, Cipolletta F, Cipolletta L, Conigliaro R, Conte D, Costamagna G, D’ Amico G, De Fanis C, De Filippo FR, de Franchis R, Dell‘ Era A, De Nigris F, De Matthaeis M, Di Giorgio P, Di Giulio E, Esposito P, Ferraris L, Filippino A, Franceschi M, Furio L, Germana B, Grassia R, Imperiali G, Lamanda R, Lauri A, Londoni C, Mangiafico S, Manno M, Marmo C, Meroni R, Metrangolo S, Montalbano L. M, Napolitano G, Nucci A, Orsini L, Parente F, Parravicini M, Paterlini A, Pumpo R, Purita L, Repici A, Riccioni ME, Russo A, Segato S, Sorrentino I, Spinzi G, Spotti D, Tortora A, Triossi O, Zagari RM, and Zambelli A

Subjects
Cohort Studies, Area Under Curve, Acute Disease, Gastroenterology, Humans, Radiology, Nuclear Medicine and imaging, Gastrointestinal Hemorrhage, Prognosis, Risk Assessment, Severity of Illness Index
Abstract

Scores in upper GI bleeding (UGIB) are used to stratify death risk and need for hospitalization at admission, but a tool that incorporates dynamic changes during the hospital stay is lacking. We aimed to develop a death risk score that considers changes in clinical status during hospitalization and compare its performance with existing ones.A multicenter cohort study enrolling patients with UGIB in 50 Italian hospitals from January 2014 to December 2015 was conducted. Data were collected and used to develop a risk score using logistic regression analyses. Performance curves (area under the receiver-operating characteristic [AUROC] curves), sensitivities, specificities, positive and negative predictive values, and outcomes classified as low, intermediate, and high death risk were calculated. The score's performance was externally validated and then compared with other scores.We included 1852 patients with nonvariceal UGIB in the development cohort and 912 in the validation cohorts. The new score, which we named the Re.Co.De (rebleeding-comorbidities-deteriorating) score, included 10 variables depicting the changes in clinical conditions while in the hospital. The mortality AUROC curves were .93 (95% confidence interval, .91-.96) in the derivation cohort and .94 (95% confidence interval, .91-.98) in validation cohort. In a comparison of AUROC curves with other scores, the new score showed a significant performance compared with pre- and postendoscopy scores. Patients with low and high scores had 30-day mortality rates of .001% and 48.2%, respectively.The Re.Co.De score has a higher performance for predicting mortality in patients with UGIB compared with other scores, correctly identifying patients at low and high death risk while in the hospital through a dynamic re-evaluation of clinical status.

Published
2021

19. SIUMB recommendations for focal pancreatic lesions

Author

D'Onofrio M., de Sio I., Mirk P., Vidili G., Bertolotto M., Cantisani V., Schiavone C., Accogli E., Attili F., Basilico R., Brizi M. G., Buscarini E., Caiazzo C., Calliada F., Carriero A., Casadei A., Catalano O., D'Anneo G., De Prizio M., Di Candio G., Draghi F., Drudi F. M., Ferraioli G., Francica G., Granata A., Iannetti G., Maconi G., Magnolfi F., Piscaglia F., Pompili M., Rapaccini G. L., Sconfienza L. M., Serra C., Soresi M., Speca S., Stramare R., Tarantino L., Valentino M., Vallone G., D'Onofrio M., de Sio I., Mirk P., Vidili G., Bertolotto M., Cantisani V., Schiavone C., Accogli E., Attili F., Basilico R., Brizi M.G., Buscarini E., Caiazzo C., Calliada F., Carriero A., Casadei A., Catalano O., D'Anneo G., De Prizio M., Di Candio G., Draghi F., Drudi F.M., Ferraioli G., Francica G., Granata A., Iannetti G., Maconi G., Magnolfi F., Piscaglia F., Pompili M., Rapaccini G.L., Sconfienza L.M., Serra C., Soresi M., Speca S., Stramare R., Tarantino L., Valentino M., and Vallone G.

Subjects
Image-Guided Biopsy, medicine.medical_specialty, Percutaneous, Contrast Media, 030218 nuclear medicine & medical imaging, Diagnosis, Differential, 03 medical and health sciences, Pancreatic cystic lesion, 0302 clinical medicine, Pancreatic cancer, CEUS, Contrast-enhanced ultrasound, Pancreas, Pancreatic adenocarcinoma, Pancreatic biopsy, Pancreatic cystic lesions, Ultrasound, Humans, Pancreatic Cyst, Pancreatic Neoplasms, Ultrasonography, Diagnosis, CEUS, Ultrasound, Contrast-enhanced ultrasound, Pancreas, Pancreatic adenocarcinoma, Pancreatic cystic lesions, Pancreatic biopsy, Pancreatic cancer, Internal Medicine, medicine, Pancrea, Radiology, Nuclear Medicine and imaging, 030219 obstetrics & reproductive medicine, business.industry, General surgery, General Medicine, Guideline, medicine.disease, medicine.anatomical_structure, Differential, Original Article, Differential diagnosis, business
Abstract

Contrast-enhanced ultrasonography (CEUS) is increasingly being performed in Italy and Europe, particularly in the field of hepato-gastroenterology. Initially, it was mainly carried out to characterize focal hepatic lesions, but, since then, numerous studies have demonstrated its efficacy in the differential diagnosis of focal pancreatic pathologies (D’Onofrio et al. in Expert Rev Med Devices 7(2):257–273, 2010; Vidili et al. in J Ultrasound 22(1):41–51, 2019). The purpose of this paper is to provide Italian Medical Doctors with recommendations and thereby practical guidelines on the management of these patients. The present paper reports the final conclusions reached by the SIUMB guideline commission. This paper addresses particularly percutaneous ultrasound (US) examination (transabdominal US) and is drawn up specifically for publication.

Published
2020

20. The "Hub and Spoke" model has no effect on mortality in acute upper gastrointestinal bleeding: A prospective multicenter cohort study

Author

Marmo, Riccardo, primary, Soncini, Marco, additional, Bucci, Cristina, additional, Zullo, Angelo, additional, Amitrano, L, additional, Anderloni, A, additional, Andriulli, A, additional, Annese, V, additional, Baldassarre, G, additional, Bargiggia, S, additional, Bazzoli, F, additional, Bennato, R, additional, Bianco, MA, additional, Bizzotto, A, additional, Boarino, V, additional, Bonanomi, AG, additional, Borgheresi, P, additional, Bresci, G, additional, Buffoli, F, additional, Buscarini, E, additional, Castrignanò, G, additional, Cavallaro, LG, additional, Cesaro, P, additional, Chirico, A, additional, Cipolletta, F, additional, Cipolletta, L, additional, Conigliaro, R, additional, Conte, D, additional, Costamagna, G, additional, Covello, F, additional, D'Amico, G, additional, De-Fanis, C, additional, De-Filippo, FR, additional, de-Franchis, R, additional, Dell‘Era, A, additional, De Nigris, F, additional, De-Matthaeis, M, additional, Di-Giorgio, P, additional, Di-Giulio, E, additional, Esposito, P, additional, Ferraris, L, additional, Filippino, A, additional, Franceschi, M, additional, Furio, L, additional, Germana', B, additional, Grassia, R, additional, Imperiali, G, additional, Lamanda, R, additional, Lauri, A, additional, Londoni, C, additional, Mangiafico, S, additional, Manno, M, additional, Marmo, C, additional, Merighi, A, additional, Meroni, R., additional, Metrangolo, S, additional, Montalbano, LM, additional, Napolitano, G, additional, Nucci, A, additional, Orsini, L, additional, Parente, F, additional, Parravicini, M, additional, Paterlini, A, additional, Pumpo, R, additional, Purita, L, additional, Repici, A, additional, Riccioni, ME, additional, Russo, A, additional, Segato, S, additional, Sorrentino, I, additional, Spinzi, G, additional, Spotti, D, additional, Tortora, A, additional, Tomba, C, additional, Triossi, O, additional, Zagari, RM, additional, and Zambelli, A, additional

Published
2021
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22. Infection Control Practices and Outcomes of Endoscopy Units in the Lombardy Region of Italy A Survey From the Italian Society of Digestive Endoscopy During COVID-19 Spread

Author

Capurso, G., Archibugi, L., Vanella, G., Testoni, S. G. G., Petrone, M. C., Fanti, Lucrezia, Greco, Sara, Cavenati, S., Gaffuri, N., Lella, F., Pace, F., Cengia, G., Spada, Cristiano, Lovera, Mauro, Missale, G., Rosato, S., Radaelli, F., Buscarini, E., Parente, F., Pilati, S., Luigiano, C., Passoni, G. R., Salerno, R., Bargiggia, S., Penagini, R., Cantu, P., Fregoni, F., Giannetti, A., Devani, M., Manes, G., Fiori, G., Fontana, Paolo, Gambitta, P., Masci, E., Mutignani, Massimiliano, Gatti, M., Canani, M. B., Vailati, C., Dinelli, M. E., Marzo, V., Alvisi, C., Caramia, V., Di Sabatino, A., Mauro, A., De Grazia, F., Balzarini, M., Segato, S., Nella, G. A., Giannini, P., Leoni, Paola, Testoni, P. A., Mariani, A., Arcidiacono, P. G., Fanti L. (ORCID:0000-0003-2457-6373), Greco S., Spada C. (ORCID:0000-0002-5692-0960), Lovera M., Fontana P., Mutignani M. (ORCID:0000-0002-1272-4888), Leoni P., Capurso, G., Archibugi, L., Vanella, G., Testoni, S. G. G., Petrone, M. C., Fanti, Lucrezia, Greco, Sara, Cavenati, S., Gaffuri, N., Lella, F., Pace, F., Cengia, G., Spada, Cristiano, Lovera, Mauro, Missale, G., Rosato, S., Radaelli, F., Buscarini, E., Parente, F., Pilati, S., Luigiano, C., Passoni, G. R., Salerno, R., Bargiggia, S., Penagini, R., Cantu, P., Fregoni, F., Giannetti, A., Devani, M., Manes, G., Fiori, G., Fontana, Paolo, Gambitta, P., Masci, E., Mutignani, Massimiliano, Gatti, M., Canani, M. B., Vailati, C., Dinelli, M. E., Marzo, V., Alvisi, C., Caramia, V., Di Sabatino, A., Mauro, A., De Grazia, F., Balzarini, M., Segato, S., Nella, G. A., Giannini, P., Leoni, Paola, Testoni, P. A., Mariani, A., Arcidiacono, P. G., Fanti L. (ORCID:0000-0003-2457-6373), Greco S., Spada C. (ORCID:0000-0002-5692-0960), Lovera M., Fontana P., Mutignani M. (ORCID:0000-0002-1272-4888), and Leoni P.

Abstract

Goals: The present survey from the Italian Society of Digestive Endoscopy (SIED-Società Italiana di Endoscopia Digestiva) was aimed at reporting infection control practice and outcomes at Digestive Endoscopy Units in a high-incidence area. Background: Lombardy was the Italian region with the highest coronavirus disease-2019 (COVID-19) prevalence, at the end of March 2020 accounting for 20% of all worldwide deaths. Joint Gastro-Intestinal societies released recommendations for Endoscopy Units to reduce the risk of the contagion. However, there are few data from high-prevalence areas on adherence to these recommendations and on their efficacy. Methods: A survey was designed by the Lombardy section of SIED to analyze (a) changes in activity and organization, (b) adherence to recommendations, (c) rate of health care professionals' (HCP) infection during the COVID-19 outbreak. Results: In total, 35/61 invited centers (57.4%) participated; most modified activities were according to recommendations and had filtering face piece 2/filtering face piece 3 and water-repellent gowns available, but few had negative-pressure rooms or provided telephonic follow-up; 15% of HCPs called in sick and 6% had confirmed COVID-19. There was a trend (P = 0.07) toward different confirmed COVID-19 rates among endoscopists (7.9%), nurses (6.6%), intermediate-care technicians (3.4%), and administrative personnel (2.2%). There was no correlation between the rate of sick HCPs and COVID-19 incidence in the provinces and personal protective equipment availability and use, whereas an inverse correlation with hospital volume was found. Conclusions: Adherence to recommendations was rather good, though a minority were able to follow all recommendations. Confirmed COVID-19 seemed higher among endoscopists and nurses, suggesting that activities in the endoscopy rooms are at considerable viral spread risk.

Published
2021

26. Endoscopy units and the COVID-19 Outbreak: A Multi-Center Experience from Italy

Author

Repici, A, Pace, F, Gabbiadini, R, Colombo, M, Hassan, C, Dinelli, M, Maselli, R, Spadaccini, M, Mutignani, M, Gabbrielli, A, Signorelli, C, Spada, C, Leoni, P, Fabbri, C, Segato, S, Gaffuri, N, Mangiavillano, B, Radaelli, F, Salerno, R, Bargiggia, S, Maroni, L, Benedetti, A, Occhipinti, P, De Grazia, F, Ferraris, L, Cengia, G, Greco, S, Alvisi, C, Scarcelli, A, De Luca, L, Cereatti, F, Testoni, Pa, Mingotto, R, Aragona, G, Manes, G, Beretta, P, Amvrosiadis, G, Cennamo, V, Lella, F, Missale, G, Lagoussis, P, Triossi, O, Giovanardi, M, De Roberto, G, Canto, P, Buscarini, E, Anderloni, A, Carrara, S, Fugazza, A, Galtieri, Pa, Pellegatta, G, Antonelli, G, Rosch, T, and Sharma, P

Subjects
Coronavirus, Pandemic, Survery, COVID-19, Endoscopy
Published
2020

27. High rates of 30-day mortality in patients with cirrhosis and COVID-19

Author

Iavarone, M, D'Ambrosio, R, Soria, A, Triolo, M, Pugliese, N, Del Poggio, P, Perricone, G, Massironi, S, Spinetti, A, Buscarini, E, Viganò, M, Carriero, C, Fagiuoli, S, Aghemo, A, Belli, L, Lucà, M, Pedaci, M, Rimondi, A, Rumi, M, Invernizzi, P, Bonfanti, P, Lampertico, P, Iavarone, Massimo, D'Ambrosio, Roberta, Soria, Alessandro, Triolo, Michela, Pugliese, Nicola, Del Poggio, Paolo, Perricone, Giovanni, Massironi, Sara, Spinetti, Angiola, Buscarini, Elisabetta, Viganò, Mauro, Carriero, Canio, Fagiuoli, Stefano, Aghemo, Alessio, Belli, Luca S, Lucà, Martina, Pedaci, Marianna, Rimondi, Alessandro, Rumi, Maria Grazia, Invernizzi, Pietro, Bonfanti, Paolo, Lampertico, Pietro, Iavarone, M, D'Ambrosio, R, Soria, A, Triolo, M, Pugliese, N, Del Poggio, P, Perricone, G, Massironi, S, Spinetti, A, Buscarini, E, Viganò, M, Carriero, C, Fagiuoli, S, Aghemo, A, Belli, L, Lucà, M, Pedaci, M, Rimondi, A, Rumi, M, Invernizzi, P, Bonfanti, P, Lampertico, P, Iavarone, Massimo, D'Ambrosio, Roberta, Soria, Alessandro, Triolo, Michela, Pugliese, Nicola, Del Poggio, Paolo, Perricone, Giovanni, Massironi, Sara, Spinetti, Angiola, Buscarini, Elisabetta, Viganò, Mauro, Carriero, Canio, Fagiuoli, Stefano, Aghemo, Alessio, Belli, Luca S, Lucà, Martina, Pedaci, Marianna, Rimondi, Alessandro, Rumi, Maria Grazia, Invernizzi, Pietro, Bonfanti, Paolo, and Lampertico, Pietro

Abstract

Background & Aims: Coronavirus disease 2019 (COVID-19) poses a major health threat to healthy individuals and those with comorbidities, but its impact on patients with cirrhosis is currently unknown. Herein, we aimed to evaluate the impact of COVID-19 on the clinical outcome of patients with cirrhosis. Methods: In this multicentre retrospective study, patients with cirrhosis and a confirmed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection were enrolled between 1st and 31th March 2020. Clinical and biochemical data at diagnosis of COVID-19 and at the last outpatient visit were obtained through review of medical records. Results: Fifty patients with cirrhosis and confirmed SARS-CoV-2 infection were enrolled (age 67 years, 70% men, 38% virus-related, 52% previously compensated cirrhosis). At diagnosis, 64% of patients presented fever, 42% shortness of breath/polypnea, 22% encephalopathy, 96% needed hospitalization or a prolonged stay if already in hospital. Respiratory support was necessary in 71%, 52% received antivirals, 80% heparin. Serum albumin significantly decreased, while bilirubin, creatinine and prothrombin time significantly increased at COVID-19 diagnosis compared to last available data. The proportion of patients with a model for end-stage liver disease (MELD) score ≥15 increased from 13% to 26% (p = 0.037), acute-on-chronic liver failure and de novo acute liver injury occurred in 14 (28%) and 10 patients, respectively. Seventeen patients died after a median of 10 (4–13) days from COVID-19 diagnosis, with a 30-day-mortality rate of 34%. The severity of lung and liver (according to CLIF-C, CLIF-OF and MELD scores) diseases independently predicted mortality. In patients with cirrhosis, mortality was significantly higher in those with COVID-19 than in those hospitalized for bacterial infections. Conclusion: COVID-19 is associated with liver function deterioration and elevated mortality in patients with cirrhosis. Lay summary: Coronavirus

Published
2020

28. Endoscopy Units and the Coronavirus Disease 2019 Outbreak: A Multicenter Experience From Italy

Author

Repici, A., Pace, F., Gabbiadini, R., Colombo, M., Hassan, Cesare, Dinelli, M., Maselli, R., Spadaccini, M., Mutignani, Massimiliano, Gabbrielli, A., Signorelli, C., Spada, Cristiano, Leoni, Paola, Fabbri, Carlo, Segato, S., Gaffuri, N., Mangiavillano, B., Radaelli, F., Salerno, R., Bargiggia, S., Maroni, L., Benedetti, A., Occhipinti, P., De Grazia, F., Ferraris, L., Cengia, G., Greco, Sara, Alvisi, C., Scarcelli, A., De Luca, L., Cereatti, F., Testoni, P. A., Mingotto, R., Aragona, G., Manes, G., Beretta, P., Amvrosiadis, G., Cennamo, Vincenzo, Lella, F., Missale, G., Lagoussis, P., Triossi, O., Giovanardi, Mattia, De Roberto, G., Cantu, P., Buscarini, E., Anderloni, A., Carrara, S., Fugazza, A., Galtieri, P. A., Pellegatta, G., Antonelli, G., Rosch, T., Sharma, P., Hassan C., Mutignani M. (ORCID:0000-0002-1272-4888), Spada C. (ORCID:0000-0002-5692-0960), Leoni P., Fabbri C., Greco S., Cennamo V., Giovanardi M., Repici, A., Pace, F., Gabbiadini, R., Colombo, M., Hassan, Cesare, Dinelli, M., Maselli, R., Spadaccini, M., Mutignani, Massimiliano, Gabbrielli, A., Signorelli, C., Spada, Cristiano, Leoni, Paola, Fabbri, Carlo, Segato, S., Gaffuri, N., Mangiavillano, B., Radaelli, F., Salerno, R., Bargiggia, S., Maroni, L., Benedetti, A., Occhipinti, P., De Grazia, F., Ferraris, L., Cengia, G., Greco, Sara, Alvisi, C., Scarcelli, A., De Luca, L., Cereatti, F., Testoni, P. A., Mingotto, R., Aragona, G., Manes, G., Beretta, P., Amvrosiadis, G., Cennamo, Vincenzo, Lella, F., Missale, G., Lagoussis, P., Triossi, O., Giovanardi, Mattia, De Roberto, G., Cantu, P., Buscarini, E., Anderloni, A., Carrara, S., Fugazza, A., Galtieri, P. A., Pellegatta, G., Antonelli, G., Rosch, T., Sharma, P., Hassan C., Mutignani M. (ORCID:0000-0002-1272-4888), Spada C. (ORCID:0000-0002-5692-0960), Leoni P., Fabbri C., Greco S., Cennamo V., and Giovanardi M.

Abstract

Up to 20% of health care personnel (HCP) were found to be infected with coronavirus disease (COVID-19)1 in the outbreak in northern Italy.2 Recommendations on patient and HCP protection have been made, such as postponing procedures, triage, use of personal protective equipment (PPE), and creation of differentiated in-hospital pathways.3,4 However, several barriers against the adoption of these strategies exist, including cultural factors and shortages of medical resources; therefore, there are few reports of real-world experiences and outcomes with their adoption.5 The aim of this survey was to investigate the burden of COVID-19 on endoscopic activity in a high-risk area of COVID-19 outbreak, approaches to evaluating patients, adoption and compliance of HCP with protective measures, and initial possible viral transmission outcomes from endoscopy units within a large, community-based setting (both between patients and HCP and between HCP).

Published
2020

29. Reply to: Correspondence on “High rates of 30-day mortality in patients with cirrhosis and COVID-19”

Author

Iavarone, Massimo, primary, D'Ambrosio, Roberta, additional, Lampertico, Pietro, additional, Iavarone, M., additional, D’Ambrosio, R., additional, Rimondi, A., additional, Lampertico, P., additional, Soria, A., additional, Bonfanti, P., additional, Triolo, M., additional, Fagiuoli, S., additional, Pugliese, N., additional, Aghemo, A., additional, Del Poggio, P., additional, Perricone, G., additional, Belli, L.S., additional, Massironi, S., additional, Lucà, M., additional, Invernizzi, P., additional, Spinetti, A., additional, Carriero, C., additional, Buscarini, E., additional, Pedaci, M., additional, Viganò, M., additional, and Rumi, M.G., additional

Published
2020
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30. Multicentric Italian Survey on Daily Practice for Autoimmune Pancreatitis: Clinical Data, Diagnosis, Treatment, and Evolution toward Pancreatic Insufficiency

Author

Barresi, L., primary, Tacelli, M., additional, Crinò, S., additional, Attili, F., additional, Petrone, M., additional, De Nucci, G., additional, Carrara, S., additional, Manfredi, G., additional, Capurso, G., additional, De Angelis, C., additional, Crocellà, L., additional, Fantin, A., additional, Dore, M., additional, Garribba, A., additional, Tarantino, I., additional, De Pretis, N., additional, Pagliari, D., additional, Rossi, G., additional, Manes, G., additional, Preatoni, P., additional, Barbuscio, I., additional, Traina, M., additional, Frulloni, L., additional, Arcidiacono, P., additional, Costamagna, G., additional, Buscarini, E., additional, and Pezzilli, R., additional

Published
2020
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32. International guidelines for the diagnosis and management of hereditary haemorrhagic telangiectasia

Author

Faughnan, M E, Palda, V A, Garcia-Tsao, G, Geisthoff, U W, McDonald, J, Proctor, D D, Spears, J, Brown, D H, Buscarini, E, Chesnutt, M S, Cottin, V, Ganguly, A, Gossage, J R, Guttmacher, A E, Hyland, R H, Kennedy, S J, Korzenik, J, Mager, J J, Ozanne, A P, Piccirillo, J F, Picus, D, Plauchu, H, Porteous, M E M, Pyeritz, R E, Ross, D A, Sabba, C, Swanson, K, Terry, P, Wallace, M C, Westermann, C J J, White, R I, Young, L H, and Zarrabeitia, R

Published
2011
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33. T01.01.7 THE USE OF A SPECIALIZED BLEEDING-MANAGEMENT TEAM HAD NO IMPACT ON MORTALITY FOR ACUTE UPPER GASTROINTESTINAL BLEEDING: AN ITALIAN PROSPECTIVE MULTICENTER COHORT STUDY

Author

Marmo, R., primary, Soncini, M., additional, Marmo, C., additional, Bucci, C., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Amitrano, L., additional, Parente, F., additional, Bargiggia, S., additional, Paterlini, A., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, De Franchis, R., additional, Dell'Era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Spotti, D., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, Conte, D., additional, Spinzi, G., additional, Di Giulio, E., additional, D'Amico, G., additional, and Balzano, A., additional

Published
2020
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34. PC.01.3 LINKED COLOR IMAGING VERSUS WHITE-LIGHT COLONOSCOPY FOR ADENOMA DETECTION: A MULTICENTRE, RANDOMISED, CONTROLLED TRIAL IN A FIT-BASED COLORECTAL CANCER SCREENING PROGRAMME

Author

Paggi, S., primary, Radaelli, F., additional, Senore, C., additional, Maselli, R., additional, Amato, A., additional, Andrisani, G., additional, Di Matteo, F.M., additional, Cecinato, P., additional, Grillo, S., additional, Sereni, G., additional, Sassatelli, R., additional, Manfredi, G., additional, Alicante, S., additional, Buscarini, E., additional, Canova, D., additional, Milan, L., additional, Pallini, P., additional, Iwatate, M., additional, Rondonotti, E., additional, Repici, A., additional, and Hassan, C., additional

Published
2020
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35. T02.01.19 EFFICACY OF PREMEDICATION WITH SYMETICHONE AND N-ACETYLCYSTEINE IN IMPROVING VISIBILITY DURING UPPER GI ENDOSCOPY: A RANDOMIZED CONTROLLED TRIAL

Author

Bertè, R., primary, Manfredi, G., additional, Iiritano, E., additional, Alicante, S., additional, Londoni, C., additional, Brambilla, G., additional, Romeo, S., additional, Menozzi, F., additional, Griffanti, P., additional, Brandi, G., additional, Moreschi, O., additional, Pezzilli, R., additional, Zullo, A., additional, and Buscarini, E., additional

Published
2020
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38. OC.10.1 THE USE OF PRE-ENDOSCOPIC INTRAVENOUS PROTON PUMP INHIBITORS (PPIS) HAD NO IMPACT ON CLINICAL OUTCOMES IN ACUTE UPPER GASTROINTESTINAL BLEEDING: A PROSPECTIVE MULTICENTER ITALIAN COHORT STUDY

Author

Marmo, R., primary, Soncini, M., additional, Bucci, C., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Amitrano, L., additional, Parente, F., additional, Bargiggia, S., additional, Paterlini, A., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, De Franchis, R., additional, Dell'Era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Spotti, D., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, Conte, D., additional, Spinzi, G., additional, Di Giulio, E., additional, D'Amico, G., additional, and Balzano, A., additional

Published
2020
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48. Safety of direct oral anticoagulants in patients with hereditary hemorrhagic telangiectasia

Author

Team Medisch, Circulatory Health, Shovlin, C. L., Millar, C. M., Droege, F., Kjeldsen, A., Manfredi, G., Suppressa, P., Ugolini, S., Coote, N., Fialla, A. D., Geisthoff, U., Lenato, G. M., Mager, H. J., Pagella, F., Post, M. C., Sabbà, C., Sure, U., Torring, P. M., Dupuis-Girod, S., Buscarini, E., Team Medisch, Circulatory Health, Shovlin, C. L., Millar, C. M., Droege, F., Kjeldsen, A., Manfredi, G., Suppressa, P., Ugolini, S., Coote, N., Fialla, A. D., Geisthoff, U., Lenato, G. M., Mager, H. J., Pagella, F., Post, M. C., Sabbà, C., Sure, U., Torring, P. M., Dupuis-Girod, S., and Buscarini, E.

Published
2019

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