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3. Severe postoperative morbidity after left colectomy for sigmoid diverticulitis without splenic flexure mobilization. Results of a multicenter cohort study with propensity score analysis

Author

Barraud, Alexis, Sabbagh, Charles, Beyer-Berjot, Laura, Ouaissi, Mehdi, Zerbib, Philippe, Bridoux, Valérie, Manceau, Gilles, Panis, Yves, Buscail, Etienne, Venara, Aurélien, Khaoudy, Iman, Gaillard, Martin, Viennet, Manon, Thobie, Alexandre, Menahem, Benjamin, Eveno, Clarisse, Bonnel, Catherine, Mabrut, Jean-Yves, Badic, Bogdan, Godet, Camille, Eid, Yassine, Duchalais, Emilie, Lakkis, Zaher, Cotte, Eddy, Laforest, Anaïs, Defourneaux, Véronique, Maggiori, Léon, Rebibo, Lionel, Christou, Niki, Talal, Ali, Mege, Diane, Bonnamy, Cécile, Germain, Adeline, Mauvais, François, Tresallet, Christophe, Roudie, Jean, Laurent, Alexis, Trilling, Bertrand, Bertrand, Martin, Massalou, Damien, Romain, Benoit, Tranchart, Hadrien, Pellegrin, Alexandra, Briant, Anais R., Parienti, Jean Jacques, and Alves, Arnaud

Published
2024
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4. Risk factors for emergency surgery for diverticulitis: A retrospective multicentric French study at 41 hospitals

Author

Jeanne, Dembinski, Gillet, Julien, Hamy, Antoine, Lahmidi, Amine, Sebbagh, Mohamed, Bres, Antoine, Girard, Nicolas, Desjouis, Aurélie, Ainseba, Nadjib, Epailly, Julien, Huysman, Fabienne, Dezeustre, Maud, Doussot, Alexandre, Turco, Célia, Bourrhis, Diane, Godet, Camille, Finocchi, Morgane, Marion, Yoan, Lebreton, Gil, Benard, Flavie, Pineau, Elodie, Bouvier, Véronique, Ortega-Deballon, Pablo, Moreno-Lopez, Nathan, Rat, Patrick, Makar, Bassem, Fara, Paola, Pompilio, Marc, Hertault, Hugo, Guezennec, Corentin, Saida, Habchi, Brinza, Alexandre, Plard, Laurent, Ailhaud, Antoine, Gutierrez, Léa, Venchiarutti, Vincent, Faucheron, Jean-Luc, Morin, Bertrand, Pech de la Clause, Bertrand, Voitellier, Eglantine, Gagnat, Guillaume, Noiret, Barbara, Laroye, Constance, Piessen, Guillaume, Lécolle, Katia, Robert, Jean, Nzamushelepanmabla, Engel, Perrine, Mathonnet, Muriel, Rodriguez, Cyprien, Makki, Ammar, Couchard, Anne-Cécile, Duramé, François, Marceau, Cécile, Paquet, Jean-Christophe, Kepenekian, Vahan, Passot, Guillaume, Glehen ; Ninon Wallach, Olivier, Mohkam, Kayvan, Blanc, Marie-Caroline, Berdah, Stéphane, Aubert, Mathilde, Ayav, Ahmet, Chanty, Hervé, Didier, Alexandre, Vigneron, Estelle, Périard, Noémie, Thaumoux, Marie, Grenouilloux, Océane, Fall, Seila, Thomareis, Sophoclis, Marsollier, Chloé, Prud’homme, Michel, Antonopulos, Christos, Msika, Simon, Monsinjon, Marie, Giacca, Massimo, Cazelles, Antoine, Karoui, Mehdi, Malerba, Valentina, Dagher, Ibrahim, de Angelis, Nicola, Brunetti, Francesco, Ahmed, Omar, Ferraz, Jean-Marc, Ramjaun, Yassir, Denet, Christine, Fuchs, Basile, Pietrasz, Daniel, Raimbert, Pénélope, Benedetti, Juliette, Coton, Chloé, Corte, Hélène, Medrignac, Aude, Chavrier, Daphné, Girard, Robin, Berthelot, Julia, Monge, Matthieu, Papet, Eloïse, Pinson, Jean, Dolbeau, Elise, Tuech, Jean-Jacques, Chautard, Julien, Boullier, Mathilde, Goujard, François, Perrot, Laurent, Loge, Ludovic, Petiot, Jean-Michel, Manfredelli, Simone, Charleux-Muller, Diane, Sauvinet, Guillaume, Bertin, Jean-Baptiste, Vincent, Louis, Simeu, Blandine, Delhorme, Jean-Baptiste, Brigand, Cécile, Rohr, Serge, Bouchet, Manon, Duffas, Jean-Pierre, Ghouti, Laurent, Philis, Antoine, Portier, Guillaume, Karam, Elias, Michot, Nicolas, Artus, Alice, Mauny, Emilien, Bourbao-Tournois, Céline, Barbin, Hugo, Thiery, Julien, Sabbagh, Charles, Beyer-Berjot, Laura, Ouaissi, Mehdi, Zerbib, Philippe, Valérie, Bridoux, Manceau, Gilles, Panis, Yves, Buscail, Etienne, Venara, Aurélien, Khaoudy, Iman, Gaillard, Martin, Viennet, Manon, Thobie, Alexandre, Menahem, Benjamin, Eveno, Clarisse, Bonnel, Catherine, Mabrut, Jean-Yves, Badic, Bogdan, Eid, Yassine, Duchalais, Emilie, Lakkis, Zaher, Cotte, Eddy, Laforest, Anaïs, Desfourneaux-Denis, Véronique, Maggiori, Léon, Rebibo, Lionel, Niki, Christou, Talal, Ali, Mege, Diane, Bonnamy, Cécile, Germain, Adeline, Mauvais, François, Tresallet, Christophe, Roudie, Jean, Laurent, Alexis, Trilling, Bertrand, Bertrand, Martin, Massalou, Damien, Romain, Benoit, Tranchart, Hadrien, Pellegrin, Alexandra, Dejardin, Olivier, and Alves, Arnaud

Published
2024
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5. Management of adult intestinal stomas: The 2023 French guidelines

Author

Aubert, Mathilde, Buscail, Etienne, Duchalais, Emilie, Cazelles, Antoine, Collard, Maxime, Charleux-Muller, Diane, Jeune, Florence, Nuzzo, Alexandre, Pellegrin, Alexandra, Theuil, Luca, Toutain, Amandine, Trilling, Bertrand, Siproudhis, Laurent, Meurette, Guillaume, Lefevre, Jérémie H., Maggiori, Léon, and Mege, Diane

Published
2024
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8. Impact of the first wave of COVID-19 epidemy on the surgical management of sigmoid diverticular disease in France: National French retrospective study

Author

Gil, Camille, Beyer-Bergeot, Laura, Sabbagh, Charles, Zerbib, Philippe, Bridoux, Valérie, Manceau, Gilles, Panis, Yves, Buscail, Etienne, Venara, Aurélien, Khaoudy, Iman, Gaillard, Martin, Viennet, Manon, Thobie, Alexandre, Menahem, Benjamin, Eveno, Clarisse, Bonnel, Catherine, Mabrut, Jean-Yves, Badic, Bodgan, Godet, Camille, Eid, Yassine, Duchalais, Emilie, Lakkis, Zaher, Cotte, Eddy, Laforest, Anais, Defourneaux, Véronique, Maggiori, Léon, Rebibo, Lionel, Christou, Niki, Talal, Ali, Mege, Diane, Bonnamy, Cécile, Germain, Adeline, Mauvais, François, Tresallet, Christophe, Roudie, Jean, Laurent, Alexis, Trilling, Bertrand, Bertrand, Martin, Massalou, Damien, Romain, Benoit, Tranchart, Hadrien, Giger, Urs, Alves, Arnaud, and Ouaissi, Mehdi

Published
2023
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9. Daphnanes diterpenes from the latex of Hura crepitans L. and their PKCζ-dependent anti-proliferative activity on colorectal cancer cells

Author

Crossay, Elise, Jullian, Valérie, Trinel, Manon, Sagnat, David, Hamel, Dimitri, Groppi, Emie, Rolland, Corinne, Stigliani, Jean-Luc, Mejia, Kember, Cabanillas, Billy Joel, Alric, Laurent, Buscail, Etienne, El Kalamouni, Chaker, Mavingui, Patrick, Deraison, Céline, Racaud-Sultan, Claire, and Fabre, Nicolas

Published
2023
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10. Final Results of the GRECCAR-6 Trial on Waiting Period Following Neoadjuvant Radiochemotherapy for Locally Advanced Rectal Cancer: 5 Years of Follow-up.

Author

Collard, Maxime K., Mineur, Laurent, Nekrouf, Célia, Denost, Quentin, Rouanet, Philippe, de Chaisemartin, Cécile, Merdrignac, Aude, Jafari, Mehrdad, Cotte, Eddy, Desrame, Jérôme, Manceau, Gilles, Benoist, Stéphane, Buscail, Etienne, Karoui, Mehdi, Panis, Yves, Piessen, Guillaume, Saudemont, Alain, Prudhomme, Michel, Peschaud, Frédérique, and Dubois, Anne

Published
2025
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11. An unusual phenotype occurs in 15% of mismatch repair-deficient tumors and is associated with non-colorectal cancers and genetic syndromes

Author

Jaffrelot, Marion, Farés, Nadim, Brunac, Anne Cécile, Laurenty, Anne Pascale, Danjoux, Marie, Grand, David, Icher, Samira, Meilleroux, Julie, Mery, Eliane, Buscail, Etienne, Maulat, Charlotte, Toulas, Christine, Vande Perre, Pierre, Chipoulet, Edith, Bonnet, Delphine, Staub, Anne, Guimbaud, Rosine, and Selves, Janick

Published
2022
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16. Influence of Socioeconomic Deprivation on Surgical Outcomes for Patients With Sigmoid Diverticulitis in France: A Multicenter Retrospective Study.

Author

Alves, Arnaud, Sabbagh, Charles, Ouaissi, Mehdi, Zerbib, Philippe, Bridoux, Valérie, Manceau, Gilles, Panis, Yves, Buscail, Etienne, Venara, Aurélien, Khaoudy, Iman, Gaillard, Martin, Viennet, Manon, Thobie, Alexandre, Menahem, Benjamin, Eveno, Clarisse, Bonnel, Catherine, Mabrut, Jean-Yves, Badic, Bogdan, Godet, Camille, and Eid, Yassine

Abstract

Objectives: To evaluate the relationship between socioeconomic deprivation and postoperative outcomes in patients who underwent colonic resection for sigmoid diverticulitis (SD). Background: The potential impact of socioeconomic inequalities on the management of SD has been scarcely studied in the literature. Considering other gastrointestinal pathologies for which lesser access to optimal treatment and poorer survival have been shown, we hypothesize that deprivation could be associated with outcomes for SD. Methods: This multicenter retrospective study was conducted at 41 French hospitals between January 1, 2010, and August 31, 2021. The main outcome was the occurrence of severe postoperative complications on postoperative day 90, according to the Clavien- Dindo scale (≥3). The European Deprivation Index was used to approximate deprivation for each patient. Multiple imputations by a chained equation were performed to consider the influence of missing data on the results. Results: Twenty percent of the 6415 patients operated on had severe postoperative complications at 90 days. In the multivariate regression analysis, increasing age, male sex, American Society of Anesthesiologists score ≥3, conversion to laparotomy or upfront open approach, surgical procedures, and perioperative transfusion were independent risk factors for severe postoperative complications. After adjusting for age, sex, body mass index, American Society of Anesthesiologists score, emergent setting, blood transfusion, indications for surgery, surgical approach, and procedures, the probability of severe postoperative complications increased with socioeconomic deprivation (P=0.026) by day 90. Conclusions: This study highlights the potential influence of socioeconomic deprivation on the surgical outcomes of SD. Socioeconomic deprivation should be considered as a risk factor for severe postoperative complications during the preoperative assessment of the patient's medical conditions. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Fate of ileorectal anastomosis for treating Crohn's disease in the era of biologics: Results from a French retrospective multicentre cohort study.

Author

Ait Mohand, Juba, Alves, Arnaud, Brouquet, Antoine, Germain, Adeline, Bridoux, Valerie, Trilling, Bertrand, Buscail, Etienne, Valibouze, Caroline, Leroy, Maxime, Desreumaux, Pierre, and Zerbib, Philippe

Subjects
CROHN'S disease, FISHER exact test, RECTAL diseases, ABDOMINOPERINEAL resection, DISEASE relapse
Abstract

Aim: The rate of surgical recurrence following ileorectal anastomosis (IRA) in patients with Crohn's disease (CD) remains poorly understood. Most studies were conducted before the advent of biologics. Our aim was to assess the fate of IRA in patients with CD during the biologics era and identify risk factors for endoscopic, clinical, and surgical recurrence. Methods: This retrospective multicentre cohort study included patients with CD who underwent IRA between 2006 and 2022. The association of patient characteristics and postoperative measures with each type of postoperative recurrence and need for a definitive stoma was investigated using the chi‐square test or Fisher's exact test. Results: During a median follow‐up period of 60 months, the rates of endoscopic, clinical, and surgical postoperative recurrence were 70%, 59%, and 35%, respectively. The rate of perianal lesions was higher in patients who underwent a definitive stoma (70% vs. 35%, p = 0.007) and with endoscopic (50% vs. 25%, p = 0.038), clinical (54% vs. 24%, p = 0.006), and surgical (63% vs. 34%, p = 0.015) recurrence. The incidence of residual microscopic disease at the rectal margin was higher in patients with endoscopic recurrence (p = 0.047). Biologics were identified as protective factors against the need for a definitive stoma (p = 0.044). Conclusion: IRA is a good treatment option for extensive colitis in patients with CD. However, its consideration should be weighed in the presence of perianal lesions, which have been shown to be a risk factor for delayed proctectomy. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Incidence of Venous Thromboembolism in Patients With Newly Diagnosed Pancreatic Cancer and Factors Associated With Outcomes

Author

Bournet, Barbara, Canivet, Cindy, Buscail, Louis, Carrère, Nicolas, Muscari, Fabrice, Suc, Bertrand, Guimbaud, Rosine, Couteau, Corinne, Deslandres, Marion, Rivera, Pascale, Laurenty, Anne-Pascale, Fares, Nadim, Barange, Karl, Selves, Janick, Gomez-Brouchet, Anne, Napoléon, Bertrand, Pujol, Bertrand, Fumex, Fabien, Desrame, Jérôme, Lefort, Christine, Lepilliez, Vincent, Gincul, Rodica, Artru, Pascal, Clavel, Léa, Lemaistre, Anne-Isabelle, Palazzo, Laurent, Cros, Jérôme, Tubiana, Sarah, Flori, Nicolas, Senesse, Pierre, Colombo, Pierre-Emmanuel, Samail-Scalzi, Emmanuelle, Portales, Fabienne, Gourgou, Sophie, Ga, Claire Honfo, Plassot, Carine, Fraisse, Julien, Bibeau, Frédéric, Ychou, Marc, Guibert, Pierre, Fouchardière, Christelle de la, Sarabi, Matthieu, Peyrat, Patrice, Tabone-Eglinger, Séverine, Renard, Caroline, Piessen, Guillaume, Truant, Stéphanie, Saudemont, Alain, Millet, Guillaume, Renaud, Florence, Leteurtre, Emmanuelle, Gele, Patrick, Assenat, Eric, Fabre, Jean-Michel, Souche, François-Régis, Dupuy, Marie, Gorce-Dupuy, Anne-Marie, Ramos, Jeanne, Seitz, Jean-François, Hardwigsen, Jean, Norguet-Monnereau, Emmanuelle, Grandval, Philippe, Duluc, Muriel, Figarella-Branger, Dominique, Vendrely, Véronique, Subtil, Clément, Terrebonne, Eric, Blanc, Jean-Frédéric, Buscail, Etienne, Merlio, Jean-Philippe, Farge, Dominique, Gornet, Jean-Marc, Geromin, Daniela, Vanbiervliet, Geoffroy, Frin, Anne-Claire, Ouvrier, Delphine, Saint-Paul, Marie-Christine, Berthelémy, Philippe, Fouad, Chelbabi, Garcia, Stéphane, Lesavre, Nathalie, Gasmi, Mohamed, Barthet, Marc, Cottet, Vanessa, Delpierre, Cyrille, Frere, Corinne, and Connors, Jean M.

Published
2020
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19. TRPV4 stimulates colonic afferents through mucosal release of ATP and glutamate

Author

Meng, Michelle Y, primary, Paine, Luke W, additional, Sagnat, David, additional, Bello, Ivana, additional, Oldroyd, Sophie, additional, Javid, Farideh, additional, Harper, Matthew T, additional, Hockley, James RF, additional, Smith, Ewan St. John, additional, Owens, Róisín M, additional, Alric, Laurent, additional, Buscail, Etienne, additional, Welsh, Fraser, additional, Vergnolle, Nathalie, additional, and Bulmer, David C, additional

Published
2024
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20. CD63-GPC1-Positive Exosomes Coupled with CA19-9 Offer Good Diagnostic Potential for Resectable Pancreatic Ductal Adenocarcinoma

Author

Buscail, Etienne, Chauvet, Alexandre, Quincy, Pascaline, Degrandi, Olivier, Buscail, Camille, Lamrissi, Isabelle, Moranvillier, Isabelle, Caumont, Charline, Verdon, Severine, Brisson, Alain, Marty, Marion, Chiche, Laurence, Laurent, Christophe, Vendrely, Veronique, Moreau-Gaudry, François, Bedel, Aurelie, and Dabernat, Sandrine

Published
2019
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24. Chymotrypsin activity signals to intestinal epithelium by protease‐activated receptor‐dependent mechanisms.

Author

Guignard, Simon, Saifeddine, Mahmoud, Mihara, Koichiro, Motahhary, Majid, Savignac, Magali, Guiraud, Laura, Sagnat, David, Sebbag, Mireille, Khou, Sokchea, Rolland, Corinne, Edir, Anissa, Bournet, Barbara, Buscail, Louis, Buscail, Etienne, Alric, Laurent, Camare, Caroline, Ambli, Mouna, Vergnolle, Nathalie, Hollenberg, Morley D., and Deraison, Céline

Subjects
THROMBIN receptors, INTESTINAL mucosa, CHYMOTRYPSIN, GENETIC regulation, PROTEASE-activated receptors, WESTERN immunoblotting
Abstract

Background and Purpose: Chymotrypsin is a pancreatic protease secreted into the lumen of the small intestine to digest food proteins. We hypothesized that chymotrypsin activity may be found close to epithelial cells and that chymotrypsin signals to them via protease‐activated receptors (PARs). We deciphered molecular pharmacological mechanisms and gene expression regulation for chymotrypsin signalling in intestinal epithelial cells. Experimental Approach: The presence and activity of chymotrypsin were evaluated by Western blot and enzymatic activity tests in the luminal and mucosal compartments of murine and human gut samples. The ability of chymotrypsin to cleave the extracellular domain of PAR1 or PAR2 was assessed using cell lines expressing N‐terminally tagged receptors. The cleavage site of chymotrypsin on PAR1 and PAR2 was determined by HPLC–MS analysis. The chymotrypsin signalling mechanism was investigated in CMT93 intestinal epithelial cells by calcium mobilization assays and Western blot analyses of (ERK1/2) phosphorylation. The transcriptional consequences of chymotrypsin signalling were analysed on colonic organoids. Key Results: We found that chymotrypsin was present and active in the vicinity of the colonic epithelium. Molecular pharmacological studies have shown that chymotrypsin cleaves both PAR1 and PAR2 receptors. Chymotrypsin activated calcium and ERK1/2 signalling pathways through PAR2, and this pathway promoted interleukin‐10 (IL‐10) up‐regulation in colonic organoids. In contrast, chymotrypsin disarmed PAR1, preventing further activation by its canonical agonist, thrombin. Conclusion and Implications: Our results highlight the ability of chymotrypsin to signal to intestinal epithelial cells via PARs, which may have important physiological consequences in gut homeostasis. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Stenosis of the colorectal anastomosis after surgery for diverticulitis: A national retrospective cohort study.

Author

Hamel, Jean‐Francois, Alves, Arnaud, Beyer‐Bergot, Laura, Zerbib, Philippe, Bridoux, Valérie, Manceau, Gilles, Panis, Yves, Buscail, Etienne, Khaoudy, Iman, Gaillard, Martin, Viennet, Manon, Thobie, Alexandre, Menahem, Benjamin, Eveno, Clarisse, Bonnel, Catherine, Mabrut, Jean‐Yves, Badic, Bodgan, Godet, Camille, Eid, Yassine, and Duchalais, Emilie

Subjects
DIVERTICULITIS, STENOSIS, SURGICAL anastomosis, SURGICAL emergencies, MESENTERIC artery, ILEOSTOMY
Abstract

Aim: The aim of this work was to investigate the association between early postoperative anastomotic leakage or pelvic abscess (AL/PA) and symptomatic anastomotic stenosis (SAS) in patients after surgery for left colonic diverticulitis. Method: This is a retrospective study based on a national cohort of diverticulitis surgery patients carried out by the Association Française de Chirurgie. The assessment was performed using path analyses. The database included 7053 patients operated on for colonic diverticulitis, with surgery performed electively or in an emergency, by open access or laparoscopically. Patients were excluded from the study analysis where there was (i) right‐sided diverticulitis (the initial database included all consecutive patients operated on for colonic diverticulitis), (ii) no anastomosis was performed during the first procedure or (iii) missing information about stenosis, postoperative abscess or anastomotic leakage. Results: Of the 4441 patients who were included in the final analysis, AL/PA occurred in 327 (4.6%) and SAS occurred in 82 (1.8%). AL/PA was a significant independent factor associated with a risk for occurrence of SAS (OR = 3.41, 95% CI = 1.75–6.66), as was the case for diverting stoma for ≥100 days (OR = 2.77, 95% CI = 1.32–5.82), while central vessel ligation proximal to the inferior mesenteric artery was associated with a reduced risk (OR = 0.41; 95% CI = 0.19–0.88). Diverting stoma created for <100 days or ≥100 days was also a factor associated with a risk for AL/PA (OR = 3.08, 95% CI = 2–4.75 and OR = 12.95, 95% CI = 9.11–18.50). Interestingly, no significant association between radiological drainage or surgical management of AL/PA and SAS could be highlighted. Conclusion: AL/PA was an independent factor associated with the risk for SAS. The treatment of AL/PA was not associated with the occurrence of anastomotic stenosis. Diverting stoma was associated with an increased risk of both AL/PA and SAS, especially if it was left for ≥100 days. Physicians must be aware of this information in order to decide on the best course of action when creating a stoma during elective or emergency surgery. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Les auteurs

Author

Buscail, Louis, primary, Bournet, Barbara, additional, Carrère, Nicolas, additional, Muscari, Fabrice, additional, Otal, Philippe, additional, Buscail, Etienne, additional, Culetto, Adrian, additional, Fares, Nadim, additional, Maulat, Charlotte, additional, Péré, Guillaume, additional, Pouplin, Julien, additional, Valentin, Claire, additional, and Wallyn, Marion, additional

Published
2021
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28. Risk factors for emergency surgery for diverticulitis: A retrospective multicentric French study at 41 hospitals.

Author

Godet, Camille, Sabbagh, Charles, Beyer-Berjot, Laura, Ouaissi, Mehdi, Zerbib, Philippe, Valérie, Bridoux, Manceau, Gilles, Panis, Yves, Buscail, Etienne, Venara, Aurélien, Khaoudy, Iman, Gaillard, Martin, Viennet, Manon, Thobie, Alexandre, Menahem, Benjamin, Eveno, Clarisse, Bonnel, Catherine, Mabrut, Jean-Yves, Badic, Bogdan, and Chautard, Julien

Abstract

The observed increase in the incidence of complicated diverticulitis may lead to the performance of more emergency surgeries. This study aimed to assess the rate and risk factors of emergency surgery for sigmoid diverticulitis. The primary outcomes were the rate of emergency surgery for sigmoid diverticulitis and its associated risk factors. The urgent or elective nature of the surgical intervention was provided by the surgeon and in accordance with the indication for surgical treatment. A mixed logistic regression with a random intercept after multiple imputations by the chained equation was performed to consider the influence of missing data on the results. Between 2010 and 2021, 6,867 patients underwent surgery for sigmoid diverticulitis in the participating centers, of which one-third (n = 2317) were emergency cases. In multivariate regression analysis with multiple imputation by chained equation, increasing age, body mass index <18.5 kg/m2, neurologic and pulmonary comorbidities, use of anticoagulant drugs, immunocompromised status, and first attack of sigmoid diverticulitis were independent risk factors for emergency surgery. The likelihood of emergency surgery was significantly more frequent after national guidelines, which were implemented in 2017, only in patients with a history of sigmoid diverticulitis attacks. The present study highlights a high rate (33%) of emergency surgery for sigmoid diverticulitis in France, which was significantly associated with patient features and the first attack of diverticulitis. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Postoperative ileus after digestive surgery: Network meta‐analysis of pharmacological intervention

Author

Buscail, Etienne, primary, Planchamp, Thibault, additional, Le Cosquer, Guillaume, additional, Bouchet, Manon, additional, Thevenin, Julie, additional, Carrere, Nicolas, additional, Muscari, Fabrice, additional, Abbo, Olivier, additional, Maulat, Charlotte, additional, Weyl, Ariane, additional, Duffas, Jean Pierre, additional, Philis, Antoine, additional, Ghouti, Laurent, additional, Canivet, Cindy, additional, Motta, Jean Paul, additional, Vergnolle, Nathalie, additional, Deraison, Celine, additional, and Shourick, Jason, additional

Published
2023
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32. Postoperative ileus after digestive surgery: Network meta‐analysis of pharmacological intervention.

Author

Buscail, Etienne, Planchamp, Thibault, Le Cosquer, Guillaume, Bouchet, Manon, Thevenin, Julie, Carrere, Nicolas, Muscari, Fabrice, Abbo, Olivier, Maulat, Charlotte, Weyl, Ariane, Duffas, Jean Pierre, Philis, Antoine, Ghouti, Laurent, Canivet, Cindy, Motta, Jean Paul, Vergnolle, Nathalie, Deraison, Celine, and Shourick, Jason

Subjects
*DRUG therapy, *BOWEL obstructions, *ABDOMINAL surgery, *BAYESIAN analysis, *RANDOMIZED controlled trials
Abstract

Aims: Several medicinal treatments for avoiding postoperative ileus (POI) after abdominal surgery have been evaluated in randomized controlled trials (RCTs). This network meta‐analysis aimed to explore the relative effectiveness of these different treatments on ileus outcome measures. Methods: A systematic literature review was performed to identify RCTs comparing treatments for POI following abdominal surgery. A Bayesian network meta‐analysis was performed. Direct and indirect comparisons of all regimens were simultaneously compared using random‐effects network meta‐analysis. Results: A total of 38 RCTs were included in this network meta‐analysis reporting on 6371 patients. Our network meta‐analysis shows that prokinetics significantly reduce the duration of first gas (mean difference [MD] = 16 h; credible interval −30, −3.1; surface under the cumulative ranking curve [SUCRA] 0.418), duration of first bowel movements (MD = 25 h; credible interval −39, −11; SUCRA 0.25) and duration of postoperative hospitalization (MD −1.9 h; credible interval −3.8, −0.040; SUCRA 0.34). Opioid antagonists are the only treatment that significantly improve the duration of food recovery (MD −19 h; credible interval −26, −14; SUCRA 0.163). Conclusion: Based on our meta‐analysis, the 2 most consistent pharmacological treatments able to effectively reduce POI after abdominal surgery are prokinetics and opioid antagonists. The absence of clear superiority of 1 treatment over another highlights the limits of the pharmacological principles available. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Chymotrypsin activity signals to intestinal epithelium by Protease-Activated Receptor-dependent mechanisms

Author

Guignard, Simon, primary, Saifeddine, Mahmoud, additional, Mihara, Koichiro, additional, Motahhary, Majid, additional, Savignac, Magali, additional, Guiraud, Laura, additional, Sagnat, David, additional, sebbag, mireille, additional, Khou, Sokchea, additional, Rolland, Corinne, additional, Bournet, Barbara, additional, Buscail, Louis, additional, Buscail, Etienne, additional, Alric, Laurent, additional, Camare, Caroline, additional, Ambli, Mouna, additional, Vergnolle, Nathalie, additional, Hollenberg, Morley, additional, Deraison, Celine, additional, and Bonnart, Chrystelle, additional

Published
2023
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34. Iatrogenic ureteral injury during colorectal surgery has a significant impact on patient outcomes: a French multicentric retrospective cohort study

Author

Sérénon, Victor, Rouanet, Philippe, Charleux-Muller, Diane, Eveno, Clarisse, Poirot, Karine, Trilling, Bertrand, Benoist, Stéphane, Manceau, Gilles, Panis, Yves, Alves, Arnaud, Kartheuser, Alex, Venara, Aurélien, Pocard, Marc, Sabbagh, Charles, Laforest, Anaïs, Lakkis, Zaher, Badic, Bogdan, Chau, Amélie, Christou, Niki, Beyer-Berjot, Laura, Dumont, Frederic, Germain, Adeline, Valverde, Alain, Duchalais, Emilie, Ouaissi, Mehdi, Benhaim, Leonor, Collard, Maxime, Tuech, Jean‐jacques, Buscail, Etienne, Mege, Diane, Régimbeau, Jean-Marc, Aix-Marseille Université - École de médecine (AMU SMPM MED), Aix-Marseille Université - Faculté des sciences médicales et paramédicales (AMU SMPM), Aix Marseille Université (AMU)-Aix Marseille Université (AMU), CRLC Val d'Aurelle-Paul Lamarque, CRLCC Val d'Aurelle - Paul Lamarque, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications Grenoble - UMR 5525 (TIMC-IMAG), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), CHU Grenoble, AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Aix-Marseille Université - Faculté de médecine (AMU MED), Aix Marseille Université (AMU), Service de Chirurgie Viscérale et Digestive [CHU Caen], CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers (ANTICIPE), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Caen Normandie - UFR Santé (UNICAEN Santé), Normandie Université (NU)-Normandie Université (NU), Université Catholique de Louvain = Catholic University of Louvain (UCL), Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Université d'Angers (UA), CArcinose Péritoine Paris-Technologies (ex-CART) (CAP Paris-Tech (UMR_S_1275)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Chirurgie digestive [CHU Amiens], CHU Amiens-Picardie, Simplification des soins chez les patients complexes - UR UPJV 7518 (SSPC), Université de Picardie Jules Verne (UPJV), Sorbonne Université (SU), CHU Saint-Antoine [AP-HP], Service d'Oncologie Médicale [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratoire de Traitement de l'Information Medicale (LaTIM), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Contrôle de l’Activation Cellulaire, Progression Tumorale et Résistance thérapeutique (CAPTuR), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Service de Chirurgie digestive, endocrinienne et générale [CHU Limoges], CHU Limoges, and The French Research Group of Rectal Cancer Surgery = Groupe de Recherche en Chirurgie du Rectum (GRECCAR)

Subjects
ureteral injury, colorectal surgery, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, chemotherapy, ureteral stent
Abstract

International audience; Aim: The long-term urological sequelae after iatrogenic ureteral injury (IUI) during colorectal surgery are not clearly known. The aims of this work were to report the incidence of IUI and to analyse the long-term consequences of urological late complications and their impact on oncological results of IUI occurring during colorectal surgery through a French multicentric experience (GRECCAR group).Method: All the patients who presented with IUI during colorectal surgery between 2010 and 2019 were retrospectively included. Patients with ureteral involvement needing en bloc resection, delayed ureteral stricture or noncolorectal surgery were not considered.Results: A total of 202 patients (93 men, mean age 63 ± 14 years) were identified in 29 centres, corresponding to 0.32% of colorectal surgeries (n = 63 562). Index colorectal surgery was mainly oncological (n = 130, 64%). IUI was diagnosed postoperatively in 112 patients (55%) after a mean delay of 11 ± 9 days. Intraoperative diagnosis of IUI was significantly associated with shorter length of stay (21 ± 22 days vs. 34 ± 22 days, p < 0.0001), lower rates of postoperative hydronephrosis (2% vs. 10%, p = 0.04), anastomotic complication (7% vs. 22.5%, p = 0.002) and thromboembolic event (0% vs. 6%, p = 0.02) than postoperative diagnosis of IUI. Delayed chemotherapy because of IUI was reported in 27% of patients. At the end of the follow-up [3 ± 2.6 years (1 month-13 years)], 72 patients presented with urological sequalae (36%). Six patients (3%) required a nephrectomy.Conclusion: IUI during colorectal surgery has few consequences for the patients if recognized early. Long-term urological sequelae can occur in a third of patients. IUI may affect oncological outcomes in colorectal surgery by delaying adjuvant chemotherapy, especially when the ureteral injury is not diagnosed peroperatively.

Published
2023
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35. Post-Operative Ileus After Digestive Surgery: Network Meta-Analysis of Pharmacological Intervention.

Author

Buscail, Etienne, primary, Planchamp, Thibault, additional, Cosquer, Guillaume Le, additional, Bouchet, Manon, additional, Thevenin, Julie, additional, Carrere, Nicolas, additional, Muscari, Fabrice, additional, Abbo, Olivier, additional, Maulat, Charlotte, additional, Weyl, Ariane, additional, Duffas, Jean Pierre, additional, Ghouti, Laurent, additional, Canivet, Cindy, additional, Philis, Antoine, additional, Motta, Jean Paul, additional, Vergnolle, Nathalie, additional, Deraison, Celine, additional, and Shourick, Jason, additional

Published
2023
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37. Study of postoperative complications after the implementation of a multidisciplinary care pathway for patients with digestive endometriosis

Author

Weyl, Ariane, primary, Sevy, Virginie, additional, Lepage, Benoît, additional, Vidal, Fabien, additional, Kirzin, Sylvain, additional, Legac, Yann Tanguy, additional, Lesourd, Florence, additional, Gosset, Anna, additional, Capdet, Jérome, additional, Leguevaque, Pierre, additional, Bournet, Barbara, additional, Lenfant, Françoise, additional, Brierre, Thibaut, additional, Gornes, Hugo, additional, Buscail, Etienne, additional, and Chantalat, Elodie, additional

Published
2022
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46. Neoadjuvant treatment for borderline resectable pancreatic adenocarcinoma is associated with higher R0 rate compared to upfront surgery

Author

Terlizzi, Mario, primary, Buscail, Etienne, additional, Boussari, Olayidé, additional, Adgié, Sarah, additional, Leduc, Nicolas, additional, Terrebonne, Eric, additional, Smith, Denis, additional, Blanc, Jean-Frédéric, additional, Lapuyade, Bruno, additional, Laurent, Christophe, additional, Chiche, Laurence, additional, Belleannée, Geneviève, additional, Le Malicot, Karine, additional, Trouette, Renaud, additional, Pouypoudat, Claudia, additional, and Vendrely, Véronique, additional

Published
2021
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47. Circulating Tumor Cell Clusters: United We Stand Divided We Fall

Author

Amintas, Samuel, Bedel, Aurélie, Moreau-Gaudry, François, Boutin, Julian, Buscail, Louis, Merlio, Jean-Philippe, Vendrely, Véronique, Dabernat, Sandrine, Buscail, Etienne, CHU Bordeaux [Bordeaux], Biothérapies des maladies génétiques et cancers, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Toulouse [Toulouse], Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Haut-Lévêque [CHU Bordeaux], Institut de Recherche en Santé Digestive (IRSD ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Patrick Brou de Lauriere Fondation, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), and SEGUIN, Nathalie

Subjects
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, liquid biopsy, microemboli, Clinical Decision-Making, Disease Management, [SDV.CAN]Life Sciences [q-bio]/Cancer, Review, circulating tumor cells, Neoplastic Cells, Circulating, Prognosis, CTC, circulating tumor cells clusters, lcsh:Chemistry, [SDV.CAN] Life Sciences [q-bio]/Cancer, lcsh:Biology (General), lcsh:QD1-999, Neoplasms, Biomarkers, Tumor, Animals, Humans, Neoplasm Metastasis, lcsh:QH301-705.5, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

The presence of circulating tumor cells (CTCs) and CTC clusters, also known as tumor microemboli, in biological fluids has long been described. Intensive research on single CTCs has made a significant contribution in understanding tumor invasion, metastasis tropism, and intra-tumor heterogeneity. Moreover, their being minimally invasive biomarkers has positioned them for diagnosis, prognosis, and recurrence monitoring tools. Initially, CTC clusters were out of focus, but major recent advances in the knowledge of their biogenesis and dissemination reposition them as critical actors in the pathophysiology of cancer, especially metastasis. Increasing evidence suggests that “united” CTCs, organized in clusters, resist better and carry stronger metastatic capacities than “divided” single CTCs. This review gathers recent insight on CTC cluster origin and dissemination. We will focus on their distinct molecular package necessary to resist multiple cell deaths that all circulating cells normally face. We will describe the molecular basis of their increased metastatic potential as compared to single CTCs. We will consider their clinical relevance as prognostic biomarkers. Finally, we will propose future directions for research and clinical applications in this promising topic in cancer.

Published
2020
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48. Randomised clinical trial for the cost–utility evaluation of two strategies of perineal reconstruction after abdominoperineal resection in the context of anorectal carcinoma: biological mesh repair versus primary perineal wound closure, study protocol for the GRECCAR 9 Study

Author

Buscail, Etienne, primary, Canivet, Cindy, additional, Ghouti, Laurent, additional, Kirzin, Sylvain, additional, Carrere, Nicolas, additional, Molinier, Laurent, additional, Rosillo, Aline, additional, Lauwers-Cances, Valerie, additional, and Costa, Nadège, additional

Published
2021
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49. 40 PERIPHERAL MEDIATORS INVOLVED IN SENSORY NEURONS SENSITIZATION IN IBD PATIENTS IN REMISSION: A WINDOW ON A PAR1-MEDIATED MECHANISM OF IBD-ASSOCIATED PAIN

Author

Rolland, Corinne, Rousset, Perrine, Poulen, Gaetan, Lonjon, Nicolas, Lahaye, Florence Vachiery, Bauchet, Luc, Bourinet, Emmanuel, Buscail, Louis, Bournet, Barbara, Giletta, Cyrielle, Buscail, Etienne, Cosquer, Guillaume Le, Sablayrolles, Sylvie, Grand, Bruno Le, Deraison, Celine, and Vergnolle, Nathalie

Published
2023
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50. Perineal Wound Closure Following Abdominoperineal Resection and Pelvic Exenteration for Cancer: A Systematic Review and Meta-Analysis

Author

Buscail, Etienne, primary, Canivet, Cindy, additional, Shourick, Jason, additional, Chantalat, Elodie, additional, Carrere, Nicolas, additional, Duffas, Jean-Pierre, additional, Philis, Antoine, additional, Berard, Emilie, additional, Buscail, Louis, additional, Ghouti, Laurent, additional, and Chaput, Benoit, additional

Published
2021
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