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2,310 results on '"Burzotta,Francesco"'

1. Echocardiographic left atrial stiffness index predicts high left ventricular filling pressures in patients with acute heart failure: an observational study

Author

Camilli, Massimiliano, Amore, Ludovica, Ballacci, Federico, Iannaccone, Giulia, Del Buono, Marco Giuseppe, Giordano, Federica, Graziani, Francesca, Sanna, Tommaso, Pedicino, Daniela, Burzotta, Francesco, Trani, Carlo, Lanza, Gaetano Antonio, Montone, Rocco Antonio, Aspromonte, Nadia, Lupi, Laura, Adamo, Marianna, Crea, Filippo, and Lombardo, Antonella

Published
2024
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2. Independent role of atherosclerotic plaque composition and extension in predicting the risk of cardiac events: a CLIMA substudy

Author

Budassi, Simone, Biccirè, Flavio Giuseppe, Gatto, Laura, Scorza, Marco, Marco, Valeria, Porta, Ylenia La, Sammartini, Emanuele, Paoletti, Giulia, Debelak, Caterina, Di Pietro, Riccardo, Circhetta, Simone, Albertucci, Mario, Burzotta, Francesco, Ozaki, Yukio, Canova, Paolo Angelo, Piedimonte, Giulio, Alfonso, Fernando, Arbustini, Eloisa, and Prati, Francesco

Published
2024
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3. Angiography-derived physiological patterns of coronary artery disease: implications with post-stenting physiology and long-term clinical outcomes

Author

Fezzi, Simone, Del Sole, Paolo Alberto, Burzotta, Francesco, Leone, Antonio Maria, Ding, Daixin, Terentes-Printzios, Dimitrios, Trani, Carlo, Bonizzi, Luca, Sgreva, Sara, Andreaggi, Stefano, Huang, Jiayue, Pesarini, Gabriele, Tavella, Domenico, Prado, Guy, Vicerè, Andrea, Oikonomou, Dimitrios, Gkini, Konstantia Paraskevi, Galante, Domenico, Tsioufis, Konstantinos, Vlachopoulos, Charalambos, Wijns, William, Ribichini, Flavio, Tu, Shengxian, and Scarsini, Roberto

Published
2024
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4. Inflammation and acute cardiotoxicity in adult hematological patients treated with CAR-T cells: results from a pilot proof-of-concept study

Author

Camilli, Massimiliano, Viscovo, Marcello, Felici, Tamara, Maggio, Luca, Ballacci, Federico, Carella, Giacomo, Bonanni, Alice, Lamendola, Priscilla, Tinti, Lorenzo, Di Renzo, Antonio, Coarelli, Giulia, Galli, Eugenio, Liuzzo, Giovanna, Burzotta, Francesco, Montone, Rocco Antonio, Sorà, Federica, Sica, Simona, Hohaus, Stefan, Lanza, Gaetano Antonio, Crea, Filippo, Lombardo, Antonella, and Minotti, Giorgio

Published
2024
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7. Potential Life-Threatening Complication After Transacatheter Aortic Valve Replacement: A Pseudoaneurysm of the Interventricular Septum

Author

Nesta, Marialisa, Bruno, Piergiorgio, Gambardella, Rosanna, Filice, Monica, Olimpieri, Alessandro, Pasquini, Annalisa, Pavone, Natalia, Cammertoni, Federico, Chiariello, Giovanni Alfonso, Grandinetti, Maria, Burzotta, Francesco, Romagnoli, Enrico, Aurigemma, Cristina, Muciaccia, Massimo, Costa, Federico, Trani, Carlo, and Massetti, Massimo

Published
2024
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11. Impact of repeat revascularization within 5 years on 10-year mortality after percutaneous or surgical revascularization

Author

Wang, Rutao, Lunardi, Mattia, Hara, Hironori, Gao, Chao, Ono, Masafumi, Davierwala, Piroze M., Holmes, David R., Mohr, Friedrich W., Curzen, Nick, Burzotta, Francesco, van Geuns, Robert-Jan, Kappetein, Arie Pieter, Head, Stuart J., Thuijs, Daniel J. F. M., Tao, Ling, Garg, Scot, Onuma, Yoshinobu, Wijns, William, and Serruys, Patrick W.

Published
2023
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15. Unrecognized Hole in the Aortic Stenosis Heart: Acquired Gerbode Defect Detected During Pretransfemoral Aortic Valve Implantation Evaluation

Author

Nesta, Marialisa, Bruno, Piergiorgio, d’Acierno, Edoardo Maria, Cutrone, Gessica, Rovere, Giuseppe, Burzotta, Francesco, Trani, Carlo, Romagnoli, Enrico, Aurigemma, Cristina, Infusino, Fabio, Locorotondo, Gabriella, Chiariello, Giovanni A., Cammertoni, Federico, Grandinetti, Maria, Pavone, Natalia, and Massetti, Massimo

Published
2024
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16. Optimizing Management of Stable Angina: A Patient-Centered Approach Integrating Revascularization, Medical Therapy, and Lifestyle Interventions

Author

Montone, Rocco A., Rinaldi, Riccardo, Niccoli, Giampaolo, Andò, Giuseppe, Gragnano, Felice, Piccolo, Raffaele, Pelliccia, Francesco, Moscarella, Elisabetta, Zimarino, Marco, Fabris, Enrico, de Rosa, Salvatore, Calabrò, Paolo, Porto, Italo, Burzotta, Francesco, Grigioni, Francesco, Barbato, Emanuele, Chieffo, Alaide, Capodanno, Davide, Al-Lamee, Rasha, Ford, Tom J., Brugaletta, Salvatore, Indolfi, Ciro, Sinagra, Gianfranco, Perrone Filardi, Pasquale, and Crea, Filippo

Published
2024
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19. Incidence, Predictors, and Outcomes of Paravalvular Regurgitation After TAVR in Sievers Type 1 Bicuspid Aortic Valves

Author

Zito, Andrea, Buono, Andrea, Scotti, Andrea, Kim, Won-Keun, Fabris, Tommaso, de Biase, Chiara, Bellamoli, Michele, Montarello, Nicholas, Costa, Giuliano, Alfadhel, Mesfer, Koren, Ofir, Fezzi, Simone, Bellini, Barbara, Massussi, Mauro, Bai, Lin, Costa, Giulia, Mazzapicchi, Alessandro, Giacomin, Enrico, Gorla, Riccardo, Hug, Karsten, Briguori, Carlo, Bettari, Luca, Messina, Antonio, Villa, Emmanuel, Boiago, Mauro, Romagnoli, Enrico, Orbach, Ady, Laterra, Giulia, Aurigemma, Cristina, De Carlo, Marco, Renker, Matthias, Garcia Gomez, Mario, Trani, Carlo, Ielasi, Alfonso, Landes, Uri, Rheude, Tobias, Testa, Luca, Amat Santos, Ignacio, Mangieri, Antonio, Saia, Francesco, Favero, Luca, Chen, Mao, Adamo, Marianna, Sonia Petronio, Anna, Montorfano, Matteo, Makkar, Raj R., Mylotte, Darren, Blackman, Daniel J., Barbanti, Marco, De Backer, Ole, Tchètchè, Didier, Tarantini, Giuseppe, Latib, Azeem, Maffeo, Diego, and Burzotta, Francesco

Published
2024
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21. Comparison of ultrasound- versus fluoroscopy-guidEd femorAl access In tranS-catheter aortic valve replacement In the Era of contempoRary devices: The EASIER registry

Author

Bianchini, Emiliano, Morello, Alberto, Bellamoli, Michele, Romagnoli, Enrico, Aurigemma, Cristina, Tagliaferri, Marco, Montonati, Carolina, Dumonteil, Nicolas, Cimmino, Michele, Villa, Emmanuel, Corcione, Nicola, Bettari, Luca, Messina, Antonio, Stanzione, Alessio, Troise, Giovanni, Mor, Donata, Maggi, Antonio, Bellosta, Raffaello, Pegorer, Matteo Alberto, Zoccai, Giuseppe Biondi, Ielasi, Alfonso, Burzotta, Francesco, Trani, Carlo, Maffeo, Diego, Tchétché, Didier, Buono, Andrea, and Giordano, Arturo

Published
2024
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22. Long-term impact of intravascular ultrasound-guidance for percutaneous coronary intervention on unprotected left main. The IMPACTUS-LM, an observational, multicentric study

Author

Bruno, Francesco, de Filippo, Ovidio, Sardone, Andrea, Capranzano, Piera, Conrotto, Federico, Sheiban, Imad, Giacobbe, Federico, Laudani, Claudio, Burzotta, Francesco, Saia, Francesco, Escaned, Javier, Raposeiras Roubin, Sergio, Mancone, Massimo, Templin, Christian, Candreva, Alessandro, Trabattoni, Daniela, Wanha, Wojciech, Stefanini, Giulio, Chieffo, Alaide, Cortese, Bernardo, Casella, Gianni, Wojakowski, Wojciech, Colombo, Francesco, De Ferrari, Gaetano Maria, Boccuzzi, Giacomo, D'Ascenzo, Fabrizio, and Iannaccone, Mario

Published
2024
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25. Transcatheter Aortic Valve Replacement in Patients at High Risk of Coronary Obstruction.

Author

Ahmad, Yousif, Oakley, Luke, Yoon, Sunghan, Kaewkes, Danon, Chakravarty, Tarun, Patel, Chinar, Palmerini, Tullio, Bruno, Antonio, Saia, Francesco, Testa, Luca, Bedogni, Francesco, Chieffo, Alaide, Montorfano, Matteo, Bartorelli, Antonio, Porto, Italo, Grube, Eberhard, Nickenig, Georg, Sinning, Jan-Malte, De Carlo, Marco, Petronio, Anna, Barbanti, Marco, Tamburino, Corrado, Iadanza, Alessandro, Burzotta, Francesco, Trani, Carlo, Fraccaro, Chiara, Tarantini, Giuseppe, Aranzulla, Tiziana, Musumeci, Giuseppe, Stefanini, Giulio, Taramasso, Maurizio, Kim, Hyo-Soo, Codner, Pablo, Kornowski, Ran, Pelliccia, Francesco, Vignali, Luigi, and Makkar, Raj

Subjects
Aortic stenosis, coronary obstruction, transcatheter aortic valve replacement
Abstract

BACKGROUND: Coronary obstruction following transcatheter aortic valve replacement (TAVR) is a life-threatening complication. For patients at elevated risk, it is not known how valve choice is influenced by clinical and anatomic factors and how outcomes differ between valve platforms. For patients at high risk of coronary obstruction, we sought to describe the anatomical and clinical characteristics of patients treated with both balloon-expandable (BE) and self-expanding (SE) valves. METHODS: This was a multicenter international registry of patients undergoing TAVR who are considered to be at high risk of coronary obstruction and receiving pre-emptive coronary protection. RESULTS: A total of 236 patients were included. Patients receiving SE valves were more likely to undergo valve-in-valve procedures and also had smaller sinuses of Valsalva and valve-to-coronary distance. Three-year cardiac mortality was 21.6% with SE vs 3.7% with BE valves. This was primarily driven by increased rates of definite or probable coronary occlusion, which occurred in 12.1% of patients with SE valves vs 2.1% in patients with BE valves. CONCLUSIONS: In patients undergoing TAVR with coronary protection, those treated with SE valves had increased rates of clinical and anatomic features that increase the risk of coronary obstruction. These include an increased frequency of valve-in-valve procedures, smaller sinuses of Valsalva, and smaller valve-to-coronary distances. These patients were observed to have increased cardiac mortality compared with patients treated with BE valves, but this is likely due to their higher risk clinical and anatomic phenotypes rather than as a function of the valve type itself.

Published
2022

29. Post-TAVI PCI

Author

Cangemi, Stefano, Iaizzo, Paul A., Burzotta, Francesco, Iaizzo, Paul A., editor, Iles, Tinen L., editor, Griselli, Massimo, editor, and St. Louis, James D., editor

Published
2023
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30. Impact of thrombus aspiration on left ventricular remodeling and function in patients with ST-segment elevation myocardial infarction: A meta-analysis of randomized controlled trials

Author

Bianchini, Emiliano, Lombardi, Marco, Buonpane, Angela, Ricchiuto, Alfredo, Maino, Alessandro, Laborante, Renzo, Anastasia, Gianluca, D'Amario, Domenico, Aurigemma, Cristina, Romagnoli, Enrico, Leone, Antonio Maria, D'Ascenzo, Fabrizio, Trani, Carlo, Crea, Filippo, Porto, Italo, Burzotta, Francesco, and Vergallo, Rocco

Published
2024
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31. A multimodal approach to predict prosthesis-patient mismatch in patients undergoing valve-in-valve trans-catheter aortic valve implantation

Author

Bianchini, Francesco, Romagnoli, Enrico, Aurigemma, Cristina, Lombardi, Marco, Graziani, Francesca, Iannaccone, Giulia, Locorotondo, Gabriella, Busco, Marco, Malara, Silvia, Nesta, Marialisa, Bruno, Piergiorgio, Girlando, Nunzio, Corrado, Michele, Natale, Luigi, Lombardo, Antonella, Burzotta, Francesco, and Trani, Carlo

Published
2024
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32. Sex-specific features of optical coherence tomography detected plaque vulnerability related to clinical outcomes: insights from the CLIMA study

Author

Biccirè, Flavio Giuseppe, Debelak, Caterina, Varricchione, Giuseppe, Budassi, Simone, Gatto, Laura, Romagnoli, Enrico, Di Pietro, Riccardo, Sammartini, Emanuele, Marco, Valeria, Paoletti, Giulia, Burzotta, Francesco, Ozaki, Yukio, Pastori, Daniele, Alfonso, Fernando, Arbustini, Eloisa, and Prati, Francesco

Published
2023
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33. Artificial Intelligence, Computational Simulations, and Extended Reality in Cardiovascular Interventions

Author

Samant, Saurabhi, Bakhos, Jules Joel, Wu, Wei, Zhao, Shijia, Kassab, Ghassan S., Khan, Behram, Panagopoulos, Anastasios, Makadia, Janaki, Oguz, Usama M., Banga, Akshat, Fayaz, Muhammad, Glass, William, Chiastra, Claudio, Burzotta, Francesco, LaDisa, John F., Jr., Iaizzo, Paul, Murasato, Yoshinobu, Dubini, Gabriele, Migliavacca, Francesco, Mickley, Timothy, Bicek, Andrew, Fontana, Jason, West, Nick E.J., Mortier, Peter, Boyers, Pamela J., Gold, Jeffrey P., Anderson, Daniel R., Tcheng, James E., Windle, John R., Samady, Habib, Jaffer, Farouc A., Desai, Nihar R., Lansky, Alexandra, Mena-Hurtado, Carlos, Abbott, Dawn, Brilakis, Emmanouil S., Lassen, Jens Flensted, Louvard, Yves, Stankovic, Goran, Serruys, Patrick W., Velazquez, Eric, Elias, Pierre, Bhatt, Deepak L., Dangas, George, and Chatzizisis, Yiannis S.

Published
2023
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35. Impact of Impella protected-percutaneous coronary intervention on left ventricle function recovery of patients with extensive coronary disease and poor left ventricular function

Author

Romagnoli, Enrico, Burzotta, Francesco, Cerracchio, Emma, Russo, Giulio, Aurigemma, Cristina, Pedicino, Daniela, Locorotondo, Gabriella, Graziani, Francesca, Leone, Antonio Maria, D'Amario, Domenico, Lombardo, Antonella, Malara, Silvia, Fulco, Linda, Bianchini, Francesco, Sanna, Tommaso, and Trani, Carlo

Published
2023
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37. The Role of the Association Between Serum C-Reactive Protein Levels and Coronary Plaque Macrophage Accumulation in Predicting Clinical Events — Results from the CLIMA Registry

Author

Budassi, Simone, Biccirè, Flavio Giuseppe, Paoletti, Giulia, Marco, Valeria, Boi, Alberto, Romagnoli, Enrico, Fabbiocchi, Franco, Fineschi, Massimo, Di Pietro, Riccardo, Versaci, Francesco, Calligaris, Giuseppe, Gatto, Laura, Albertucci, Mario, Ramazzotti, Vito, Burzotta, Francesco, Ozaki, Yukio, Arbustini, Eloisa, Alfonso, Fernando, and Prati, Francesco

Published
2022
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41. Editorial: Inflammation in ischemic heart disease: pathophysiology, biomarkers, and therapeutic implications

Author

Cappannoli, Luigi, Galli, Mattia, Borovac, Josip Andelo, Valeriani, Emanuele, Animati, Francesco Maria, Fracassi, Francesco, Burzotta, Francesco, Burzotta, Francesco (ORCID:0000-0002-6569-9401), Cappannoli, Luigi, Galli, Mattia, Borovac, Josip Andelo, Valeriani, Emanuele, Animati, Francesco Maria, Fracassi, Francesco, Burzotta, Francesco, and Burzotta, Francesco (ORCID:0000-0002-6569-9401)

Abstract

N/A

Published
2024

42. Acute myocardial infarction revealed by recurrent ventricular tachyarrhythmias detected by remote monitoring

Author

Bencardino, Gianluigi, Telesca, Alessandro, Comerci, Gianluca, Burzotta, Francesco, Burzotta, Francesco (ORCID:0000-0002-6569-9401), Bencardino, Gianluigi, Telesca, Alessandro, Comerci, Gianluca, Burzotta, Francesco, and Burzotta, Francesco (ORCID:0000-0002-6569-9401)

Abstract

Remote monitoring (RM) of cardiac implantable electronic devices (CIED) represented a major improvement in clinical practice and has been used with multiple indications. Many parameters monitored on a daily basis by current CIED can indeed assist in clinical practice (eg, decompensated heart failure) by providing the patient with optimal timing for anticipated outpatient visit or urgent medical care. Recognition of acute myocardial infarction (AMI) is not usually considered among the capabilities of RM. We present the case of an AMI occurring without any ischaemic symptoms but associated with recurrent ventricular tachyarrhythmias effectively treated by multiple interventions of the implantable cardioverter defibrillator and promptly detected by RM personnel, who recommended the patient to quickly access to the emergency department where diagnosis and revascularization of an otherwise untreated myocardial infarction was performed.

Published
2024

43. Progression of the ascending aorta diameter after surgical or transcatheter bicuspid aortic valve replacement

Author

Chiariello, Giovanni Alfonso, Di Mauro, Michele, Pasquini, Annalisa, Bruno, Piergiorgio, Nesta, Marialisa, Fabiani, Ludovica, Mazza, Andrea, Meloni, Martina, Baldo, Elisabetta, Ponzo, Myriana, Ferraro, Francesco, Conserva, Antonio Davide, D'Acierno, Edoardo Maria, Villa, Emmanuel, Trani, Carlo, Burzotta, Francesco, Massetti, Massimo, Bruno, Piergiorgio (ORCID:0000-0002-1075-5808), D'Acierno, Edoardo, Trani, Carlo (ORCID:0000-0001-9777-013X), Burzotta, Francesco (ORCID:0000-0002-6569-9401), Massetti, Massimo (ORCID:0000-0002-7100-8478), Chiariello, Giovanni Alfonso, Di Mauro, Michele, Pasquini, Annalisa, Bruno, Piergiorgio, Nesta, Marialisa, Fabiani, Ludovica, Mazza, Andrea, Meloni, Martina, Baldo, Elisabetta, Ponzo, Myriana, Ferraro, Francesco, Conserva, Antonio Davide, D'Acierno, Edoardo Maria, Villa, Emmanuel, Trani, Carlo, Burzotta, Francesco, Massetti, Massimo, Bruno, Piergiorgio (ORCID:0000-0002-1075-5808), D'Acierno, Edoardo, Trani, Carlo (ORCID:0000-0001-9777-013X), Burzotta, Francesco (ORCID:0000-0002-6569-9401), and Massetti, Massimo (ORCID:0000-0002-7100-8478)

Abstract

Objectives: Ascending aorta dilatation in patients with bicuspid aortic valve is related both to genetic and haemodynamic factors. Aim of this study is to compare late progression of ascending aorta dilatation in bicuspid aortic valve patients undergoing surgical aortic valve replacement (SAVR) vs transcatheter aortic valve implantation (TAVI). Methods: Data of 189 consecutive patients who underwent aortic valve replacement for severe bicuspid aortic valve stenosis were prospectively collected. Patients who underwent SAVR were compared to patients who underwent TAVI. Indication to the procedure was validated by the institutional Heart Team. Aortic diameters were evaluated by transthoracic echocardiogram. Differences between preoperative and long-term follow-up ascending aorta diameters were compared in the two groups. Results: Between January 2015 and December 2021, 143(76%) patients underwent SAVR and 46(24%) patients underwent TAVI. At 4.6 (Standard Deviation, SD 1.7) years follow-up, patients in the TAVI group showed significantly lower survival (P = 0.00013) and event-free survival (P < 0.0001). Ascending aorta diameter progression was lower in surgical compared to transcatheter patients, 0.95(0.60,1.30) mm vs 1.65(0.67, 2.63) mm, P = 0.02. Ascending aorta diameter progression indexed for body surface area and height, was lower in the surgical group: 0.72(0.38,1.05) mm/m2 vs 1.05(0.39,1.71) mm/m2 P = 0.02, and 0.59(0.36,0.81) mm/m vs 1.11(0.44,1.78) mm/m, P = 0.001, respectively. At multivariable linear regression analysis transcatheter procedure, baseline aortic diameter, and paravalvular leak were significantly associated with increased postoperative ascending aorta dilatation. Conclusions: Bicuspid aortic valve patients who underwent SAVR, showed significantly less long-term ascending aorta diameter progression than patients who underwent transcatheter procedure.

Published
2024

45. Combined ultrasound and angiographic guidance to facilitate transradial access procedures

Author

Bianchini, Francesco, Lombardi, Marco, Ricchiuto, Alfredo, Paraggio, Lazzaro, Aurigemma, Cristina, Romagnoli, Enrico, Trani, Carlo, Burzotta, Francesco, Lombardi, Marco (ORCID:0000-0001-7002-3871), Trani, Carlo (ORCID:0000-0001-9777-013X), Burzotta, Francesco (ORCID:0000-0002-6569-9401), Bianchini, Francesco, Lombardi, Marco, Ricchiuto, Alfredo, Paraggio, Lazzaro, Aurigemma, Cristina, Romagnoli, Enrico, Trani, Carlo, Burzotta, Francesco, Lombardi, Marco (ORCID:0000-0001-7002-3871), Trani, Carlo (ORCID:0000-0001-9777-013X), and Burzotta, Francesco (ORCID:0000-0002-6569-9401)

Abstract

The introduction of transradial access for percutaneous coronary diagnostic and interventional procedures has led to a decrease in access site complications. The aim of this paper is to propose a combined stepwise technical approach where real time ultrasound ("echo-first" approach) can be used to select the best vascular access and, together with angiography, to manage the potential obstacles that may occur during transradial procedures. In each section, we summarize some tips and tricks based on both our experience and current literature that can be easily implemented in daily practice to increase the success of transradial procedures.

Published
2024

46. Anatomical Annulus Predictors of New Permanent Pacemaker Implantation Risk after Balloon-expandable Trans-catheter Aortic Valve Implantation

Author

Bianchini, Francesco, Bianchini, Emiliano, Romagnoli, Enrico, Aurigemma, Cristina, Zito, Andrea, Busco, Marco, Nesta, Marialisa, Bruno, Piergiorgio, Laezza, Domenico, Giambusso, Nicole, Natale, Luigi, Pelargonio, Gemma, Burzotta, Francesco, Trani, Carlo, Bruno, Piergiorgio (ORCID:0000-0002-1075-5808), Natale, Luigi (ORCID:0000-0002-7949-5119), Burzotta, Francesco (ORCID:0000-0002-6569-9401), Trani, Carlo (ORCID:0000-0001-9777-013X), Bianchini, Francesco, Bianchini, Emiliano, Romagnoli, Enrico, Aurigemma, Cristina, Zito, Andrea, Busco, Marco, Nesta, Marialisa, Bruno, Piergiorgio, Laezza, Domenico, Giambusso, Nicole, Natale, Luigi, Pelargonio, Gemma, Burzotta, Francesco, Trani, Carlo, Bruno, Piergiorgio (ORCID:0000-0002-1075-5808), Natale, Luigi (ORCID:0000-0002-7949-5119), Burzotta, Francesco (ORCID:0000-0002-6569-9401), and Trani, Carlo (ORCID:0000-0001-9777-013X)

Abstract

New-generation transcatheter-heart-valves (THV) have significantly improved technical success and procedural safety of transcatheter-aortic-valve-implantation (TAVI) procedures, but incidence of permanent pacemaker implantation (PPI) remains a concern.The study aimed to assess the role of anatomical annulus features in determining peri-procedural conduction disturbances leading to new-PPI following TAVI with the last generation Edwards Sapien balloon-expandable valves (BEV). In the context of a prospective single-center registry, we integrated clinical and procedural predictors of PPI with anatomical data derived from multi-slice-computed-tomography (MSCT). A total of 210 consecutive patients treated with balloon expandable Edwards THV were included in the study from 2015 to 2023. Technical success was achieved in 197 (93.8%) procedures, and 26 patients (12.4%) required new-PPI at 30-day follow-up (median time-to-implantation 3 days). At the univariable logistic-regression analysis, pre-procedural right bundle branch block (RBBB; OR:2.24 [95%CI:1.01-4.97], p=0.047), annulus eccentricity ≥0.25 (OR:5.43 [95%CI:2.21-13.36], p<0.001), calcium volume at annulus of the right coronary cusp (RCC) >48 mm3 (OR:2.60 [95%CI:1.13-5.96], p=0.024) and prosthesis implantation depth greater than membranous septum length (OR:2.17 [95%CI: 1.10-4.28], p=0.026) were associated with new-PPI risk. At multivariable analysis pre-procedural RBBB (OR:2.81 [95%CI:1.01-7.85], p=0.049), annulus eccentricity ≥0.25 (OR:4.14 [95%CI:1.85-9.27], p<0.001), and annulusRCC calcium >48 mm3 (OR:2.89 [95%CI:1.07-7.82], p=0.037) were confirmed as independent predictors of new-PPI. In conclusion, specific anatomical features of the aortic valve annulus might have an additive role in determining the occurrence of conduction disturbances in patients undergoing TAVI with BEV. This suggests the possibility to use the MSCT to improve the prediction of post-TAVI new-PPI risk.

Published
2024

47. Percutaneous coronary intervention for bifurcation coronary lesions using optimised angiographic guidance: the 18th consensus document from the European Bifurcation Club

Author

Burzotta, Francesco, Louvard, Yve, Lassen, Jens Flensted, Lefèvre, Thierry, Finet, Gérard, Collet, Carlo, Legutko, Jacek, Lesiak, Maciej, Hikichi, Yutaka, Albiero, Remo, Pan, Manuel, Chatzizisis, Yiannis S, Hildick-Smith, David, Ferenc, Miroslaw, Johnson, Thomas W, Chieffo, Alaide, Darremont, Olivier, Banning, Adrian, Serruys, Patrick W, Stankovic, Goran, Burzotta, Francesco (ORCID:0000-0002-6569-9401), Burzotta, Francesco, Louvard, Yve, Lassen, Jens Flensted, Lefèvre, Thierry, Finet, Gérard, Collet, Carlo, Legutko, Jacek, Lesiak, Maciej, Hikichi, Yutaka, Albiero, Remo, Pan, Manuel, Chatzizisis, Yiannis S, Hildick-Smith, David, Ferenc, Miroslaw, Johnson, Thomas W, Chieffo, Alaide, Darremont, Olivier, Banning, Adrian, Serruys, Patrick W, Stankovic, Goran, and Burzotta, Francesco (ORCID:0000-0002-6569-9401)

Abstract

The 2023 European Bifurcation Club (EBC) meeting took place in Warsaw in October, and the latest evidence for the use of intravascular ultrasound (IVUS) and optical coherence tomography (OCT) to optimise percutaneous coronary interventions (PCI) on coronary bifurcation lesions (CBLs) was a major focus. The topic generated deep discussions and general appraisal on the potential benefits of IVUS and OCT in PCI procedures. Nevertheless, despite an increasing recognition of IVUS and OCT capabilities and their recognised central role for guidance in complex CBL and left main PCI, it is expected that angiography will continue to be the primary guidance modality for CBL PCI, principally due to educational and economic barriers. Mindful of the restricted access/adoption of intracoronary imaging for CBL PCI, the EBC board decided to review and describe a series of tips and tricks which can help to optimise angiography-guided PCI for CBLs. The identified key points for achieving an optimal angiography-guided PCI include a thorough analysis of pre-PCI images (computed tomography angiography, multiple angiographic views, quantitative coronary angiography vessel estimation), a systematic application of the technical steps suggested for a given selected technique, an intraprocedural or post-PCI use of stent enhancement and a low threshold for bailout use of intravascular imaging.

Published
2024

48. Safety and efficacy of drug-eluting stents for patients at high risk of bleedings: A network meta-analysis

Author

Giacobbe, Federico, Valente, Eduardo, Morena, Arianna, Nebiolo, Marco, Giannino, Giuseppe, De Filippo, Ovidio, Bruno, Francesco, Isaevska, Elena, Richiardi, Lorenzo, Iannaccone, Mario, Zoccai, Giuseppe Biondi, Burzotta, Francesco, D'Ascenzo, Fabrizio, Ferrari, Gaetano Maria De, Burzotta, Francesco (ORCID:0000-0002-6569-9401), Giacobbe, Federico, Valente, Eduardo, Morena, Arianna, Nebiolo, Marco, Giannino, Giuseppe, De Filippo, Ovidio, Bruno, Francesco, Isaevska, Elena, Richiardi, Lorenzo, Iannaccone, Mario, Zoccai, Giuseppe Biondi, Burzotta, Francesco, D'Ascenzo, Fabrizio, Ferrari, Gaetano Maria De, and Burzotta, Francesco (ORCID:0000-0002-6569-9401)

Abstract

Introduction: Among different coronary stents implanted in High Bleeding Risk (HBR) patients with an indication for short antiplatelet therapy, no comparisons in terms of efficacy have been provided. Methods: A Network Meta Analysis was performed including all randomized controlled trials comparing different coronary stents evaluated in HBR patients. Major Adverse Cardiovascular Events (MACEs) as defined by each included trial were the primary end point, whereas TLR (target lesion revascularization), TVR (target vessel revascularization), stent thrombosis and total and major (BARC3-5) bleedings were the secondary ones. Results: A total of four studies (ONYX ONE, LEADERS FREE, SENIOR and HBR in BIO-RESORT) including 6637 patients were analyzed with different kind of stents and dual antiplatelet therapy (DAPT) length (1 or 6 months) on 12 months follow-up. About one-third of these patients were defined HBR due to indication for oral anticoagulation. All drug eluting stents (DESs) reduced risk of MACE compared to Bare Metal Stents (BMSs) when followed by a 1-month DAPT. At SUCRA analysis, Orsiro was the device with the highest probability of performing best. Rates of TLR and TVR were significantly lower when using Resolute Onyx, Synergy and BioFreedom stents in comparison to BMS when followed by 1-month DAPT, with Synergy ranking best. Synergy also showed a significantly lower number of stent thrombosis compared to BMS (RR 0.28, 95% CI 0.06-0.93), while Orsiro and Resolute Integrity showed the highest probability of performing best. Conclusion: In HBRs patients, all DESs were superior to BMSs in terms of efficacy and safety. Among DESs, Orsiro was the one with the highest ranking in terms of MACE, mainly driven by a reduced incidence of repeated revascularization and stent thrombosis.

Published
2024

49. Coronary Physiology and Intravascular Imaging: When 2 Is Better Than 1

Author

Burzotta, Francesco, Trani, Carlo, Burzotta, Francesco (ORCID:0000-0002-6569-9401), Trani, Carlo (ORCID:0000-0001-9777-013X), Burzotta, Francesco, Trani, Carlo, Burzotta, Francesco (ORCID:0000-0002-6569-9401), and Trani, Carlo (ORCID:0000-0001-9777-013X)

Abstract

N/A

Published
2024

50. Unintended Deformation of Stents During Bifurcation PCI: An OCTOBER Trial Substudy

Author

Andreasen, Lene Nyhu, Neghabat, Omeed, Laanmets, Peep, Kumsars, Induli, Bennett, Johan, Olsen, Niels T, Odenstedt, Jacob, Burzotta, Francesco, Johnson, Thomas W, O'Kane, Peter, Hartikainen, Juha E K, Spratt, James C, Christiansen, Evald H, Holm, Niels R, Burzotta, Francesco (ORCID:0000-0002-6569-9401), Andreasen, Lene Nyhu, Neghabat, Omeed, Laanmets, Peep, Kumsars, Induli, Bennett, Johan, Olsen, Niels T, Odenstedt, Jacob, Burzotta, Francesco, Johnson, Thomas W, O'Kane, Peter, Hartikainen, Juha E K, Spratt, James C, Christiansen, Evald H, Holm, Niels R, and Burzotta, Francesco (ORCID:0000-0002-6569-9401)

Abstract

Background: Unintended deformation of implanted coronary stents can lead to loss of coronary access, stent thrombosis and coronary events during follow-up. The incidence, mechanisms and clinical outcomes of unintended stent deformations (USD) during complex bifurcation stenting are not well characterized. Objectives: In a prespecified analysis of the OCTOBER (European Trial on Optical Coherence Tomography Optimized Bifurcation Event Reduction) trial, we aimed to: 1) determine the incidence and characterize mechanisms of USD identified by optical coherence tomography (OCT); and 2) evaluate physician's detection and correction of accidental abluminal rewiring and USD. Methods: OCT scans were analyzed for accidental abluminal rewiring and USD. When USD was identified, the plausible mechanism was determined by analysis of all procedural OCT scans and the corresponding angiograms. Results: USD was identified by the core lab in 9.3% (55/589) of OCT-guided cases. Accidental abluminal rewiring was the cause in 44% (24/55), and guide catheter collision was the cause in 40% (22/55) of cases. USD was found in 18.5% of all cases with left main bifurcation percutaneous coronary intervention. The total incidence of abluminal rewiring was 33 in 32 OCT-guided cases (5.4%) and was corrected by physicians in 18 of 33 appearances (54.5%). The 2-year major adverse cardiac event rate for patients with untreated USD (n = 30) was 23.3%, whereas patients with confirmed or possibly corrected USD (n = 25) had no events during follow-up. Conclusions: USD was associated with adverse procedural complications and cardiac events during follow-up when not identified and corrected. The predominant mechanisms were undetected abluminal rewiring and guide catheter collision. Left main bifurcation percutaneous coronary intervention was a particular risk with USD detected in 18.5% of cases.

Published
2024

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