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22 results on '"Buryk, Melissa A."'

12. Molecular Characterization of Sporadic Pediatric Thyroid Carcinoma with the DNA/RNA ThyroSeq v2 Next-Generation Sequencing Assay

Author

Picarsic, Jennifer L., primary, Buryk, Melissa A., additional, Ozolek, John, additional, Ranganathan, Sarangarajan, additional, Monaco, Sara E., additional, Simons, Jeffrey P., additional, Witchel, Selma F., additional, Gurtunca, Nursen, additional, Joyce, Judith, additional, Zhong, Shan, additional, Nikiforova, Marina N., additional, and Nikiforov, Yuri E., additional

Published
2016
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14. Identification of Unique, Heterozygous Germline Mutation, STK11 (p.F354L), in a Child with an Encapsulated Follicular Variant of Papillary Thyroid Carcinoma within Six Months of Completing Treatment for Neuroblastoma

Author

Buryk, Melissa A., primary, Picarsic, Jennifer L., additional, Creary, Susan E., additional, Shaw, Peter H., additional, Simons, Jeffrey P., additional, Deutsch, Melvin, additional, Monaco, Sara E., additional, Nikiforov, Yuri E., additional, and Witchel, Selma Feldman, additional

Published
2015
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15. Can Malignant Thyroid Nodules Be Distinguished from Benign Thyroid Nodules in Children and Adolescents by Clinical Characteristics? A Review of 89 Pediatric Patients with Thyroid Nodules

Author

Buryk, Melissa A., primary, Simons, Jeffrey P., additional, Picarsic, Jennifer, additional, Monaco, Sara E., additional, Ozolek, John A., additional, Joyce, Judith, additional, Gurtunca, Nursen, additional, Nikiforov, Yuri E., additional, and Witchel, Selma Feldman, additional

Published
2015
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16. Type 1 or type 2 diabetes? What's in a name. The controversy and conundrum of diabetes type in youth and the public health impact

Author

Buryk, Melissa and Buryk, Melissa

Abstract

Type 1a diabetes (T1D) is an autoimmune condition characterized by islet cell destruction and progressive insulin deficiency, characteristically present with weight loss and thin habitus. With the rising incidence of obesity over the past several decades, the prevalence of obesity at onset of diabetes has increased. Furthermore, the incidences of both Type 2 diabetes (T2D) and T1D have significantly increased in recent years. Therefore, it has become increasingly difficult to distinguish between T1D and T2D at onset of disease in children with several hypotheses available to attempt to link these diagnoses with the theory that obesity itself may be playing a role in the increasing onset of diabetes in children. The distinction between T1D and T2D may not be of initial therapeutic importance, and may not even be a valid classification system. However, the differentiation is of importance to public health because it helps to characterize the co-morbidities of the rising obesity epidemic and plan for future health care delivery and the costs of these conditions and their comorbidities rise. With obesity leading to diabetes, improved public health efforts to stem the obesity epidemic may ultimately be able to decrease the long-term costs to the healthcare system resulting from increasing obesity epidemic. Diabetes associated autoantibodies are the traditional method used to differentiate T1D from T2D. However, patients with phenotypic T1D may be negative for autoantibodies at disease diagnosis with commonly used testing methods. Therefore, absence of antibodies, even in the presence of obesity, does not necessarily indicate the presence of T2D. We have used other markers of autoimmunity (diabetes associated T cell responses) and HLA typing to identify additional autoimmune findings in antibody negative, insulin-requiring diabetes. This enhances the argument that many autoimmune children may be classified with T2D due to the presence of obesity and evidence of insulin re

Published
2014

20. Identification of Unique, Heterozygous Germline Mutation, STK11(p.F354L), in a Child with an Encapsulated Follicular Variant of Papillary Thyroid Carcinoma within Six Months of Completing Treatment for Neuroblastoma

Author

Buryk, Melissa A., Picarsic, Jennifer L., Creary, Susan E., Shaw, Peter H., Simons, Jeffrey P., Deutsch, Melvin, Monaco, Sara E., Nikiforov, Yuri E., and Witchel, Selma Feldman

Abstract

Papillary thyroid carcinoma (PTC) is rare in children, although it is a known secondary malignancy after treatment for neuroblastoma (NB). The interval between NB treatment completion and PTC is usually more than 5 years. A 4-year-old, female patient with a high risk adrenal NB was found to have a 2.9-cm, right thyroid nodule on surveillance chest computed tomography (CT) 6 months after completion of her NB treatment (induction chemotherapy, tumor resection, autologous stem cell transplantation, external beam radiation to the abdominal tumor site, immunotherapy, and retinoic acid). Posttreatment surveillance included iodine-123-metaiodobenzylguanidine scans and CT scans. Fine-needle aspiration of the thyroid nodule diagnosed a follicular neoplasm, which was negative for BRAF, NRAS, KRAS, HRAS, PAX8/PPARg,and RET/PTCmutations, without evidence of metastatic NB. Nodule histology demonstrated an encapsulated follicular variant of PTC (FVPTC). Next-generation sequence analysis for a 46 cancer-gene profile was performed on both tumors with subsequent peripheral blood DNA testing. A heterozygous missense mutation in STK11(F354L) was identified in both the NB and FVPTC. This mutation was also detected in peripheral blood mononuclear cells. Two additional heterozygous somatic missense mutations of uncertain significance were identified: KDR/VEGFreceptor 2 (Q472H) on chromosome 4 and MET(N375S) on chromosome 7. To our knowledge, this is the shortest reported duration from completion of NB treatment to detection of thyroid cancer. The association of the STK11gene with Peutz-Jeghers syndrome, lung adenocarcinomas, and medullary thyroid cancer leads to a possible association between this genetic variant and our patient's tumors.

Published
2015
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21. Index of suspicion.

Author

Speakman, Capt Julie, Buryk, Lt Melissa, Goretzke, Sean, Srinivasan, Saranya, Growdon, Amanda, Taggart, Luke, Rothwell, Ben, Washko, Todd, Stevens, Alicia, Speakman, Julie, and Buryk, Melissa

Published
2013
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