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2. Organization and Activity of Italian Echocardiographic Laboratories: A Survey of the Italian Society of Echocardiography and Cardiovascular Imaging

Author

Ciampi, Q, Pepi, M, Antonini-Canterin, F, Barbieri, A, Barchitta, A, Faganello, G, Miceli, S, Parato, V, Tota, A, Trocino, G, Abbate, M, Accadia, M, Alemanni, R, Angelini, A, Anglano, F, Anselmi, M, Aquila, I, Aramu, S, Avogadri, E, Azzaro, G, Badano, L, Balducci, A, Ballocca, F, Barbarossa, A, Barbati, G, Barletta, V, Barone, D, Becherini, F, Benfari, G, Beraldi, M, Bergandi, G, Bilardo, G, Binno, S, Bolognesi, M, Bongiovi, S, Bragato, R, Braggion, G, Brancaleoni, R, Bursi, F, Dessalvi, C, Cameli, M, Canu, A, Capitelli, M, Capra, A, Carbonara, R, Carbone, M, Carbonella, M, Carrabba, N, Casavecchia, G, Casula, M, Chesi, E, Cicco, S, Citro, R, Cocchia, R, Colombo, B, Colonna, P, Conte, M, Corrado, G, Cortesi, P, Cortigiani, L, Costantino, M, Cozza, F, Cucchini, U, D'Angelo, M, Ros, S, D'Andrea, F, D'Andrea, A, D'Auria, F, De Caridi, G, De Feo, S, De Matteis, G, De Vecchi, S, Del Giudice, C, Dell'Angela, L, Delli Paoli, L, Dentamaro, I, Destefanis, P, Di Fulvio, M, Di Gaetano, R, Di Giannuario, G, Di Gioia, A, Di Martino, L, Di Muro, C, Di Nora, C, Di Salvo, G, Dodi, C, Dogliani, S, Donati, F, Dottori, M, Epifani, G, Fabiani, I, Ferrara, F, Ferrara, L, Ferrua, S, Filice, G, Fiorino, M, Forno, D, Garini, A, Giarratana, G, Gigantino, G, Giorgi, M, Giubertoni, E, Greco, C, Grigolato, M, Marra, W, Holzl, A, Iaiza, A, Iannaccone, A, Ilardi, F, Imbalzano, E, Inciardi, R, Inserra, C, Iori, E, Izzo, A, La Rosa, G, Labanti, G, Lanzone, A, Lanzoni, L, Lapetina, O, Leiballi, E, Librera, M, Lo Conte, C, Lo Monaco, M, Lombardo, A, Luciani, M, Lusardi, P, Magnante, A, Malagoli, A, Malatesta, G, Mancusi, C, Manes, M, Manganelli, F, Mantovani, F, Manuppelli, V, Marchese, V, Marinacci, L, Mattioli, R, Maurizio, C, Mazza, G, Mazza, S, Melis, M, Meloni, G, Merli, E, Milan, A, Minardi, G, Monaco, A, Monte, I, Montresor, G, Moreo, A, Mori, F, Morini, S, Moro, C, Morrone, D, Negri, F, Nipote, C, Nisi, F, Nocco, S, Novello, L, Nunziata, L, Perini, A, Parodi, A, Pasanisi, E, Pastorini, G, Pavasini, R, Pavoni, D, Pedone, C, Pelliccia, F, Pelliciari, G, Pelloni, E, Pergola, V, Perillo, G, Petruccelli, E, Pezzullo, C, Piacentini, G, Picardi, E, Pinna, G, Pizzarelli, M, Pizzuti, A, Poggi, M, Posteraro, A, Privitera, C, Rampazzo, D, Ratti, C, Rettegno, S, Ricci, F, Ricci, C, Rolando, C, Rossi, S, Rovera, C, Ruggieri, R, Russo, M, Sacchi, N, Saladino, A, Sani, F, Sartori, C, Scarabeo, V, Sciacqua, A, Scillone, A, Scopelliti, P, Scorza, A, Scozzafava, A, Serafini, F, Serra, W, Severino, S, Simeone, B, Sirico, D, Solari, M, Spadaro, G, Stefani, L, Strangio, A, Surace, F, Tamborini, G, Tarquinio, N, Tassone, E, Tavarozzi, I, Tchana, B, Tedesco, G, Tinto, M, Torzillo, D, Totaro, A, Triolo, O, Troisi, F, Tusa, M, Vancheri, F, Varasano, V, Venezia, A, Vermi, A, Villari, B, Zampi, G, Zannoni, J, Zito, C, Zugaro, A, Di Bella, G, Carerj, S, Ciampi Q., Pepi M., Antonini-Canterin F., Barbieri A., Barchitta A., Faganello G., Miceli S., Parato V. M., Tota A., Trocino G., Abbate M., Accadia M., Alemanni R., Angelini A., Anglano F., Anselmi M., Aquila I., Aramu S., Avogadri E., Azzaro G., Badano L., Balducci A., Ballocca F., Barbarossa A., Barbati G., Barletta V., Barone D., Becherini F., Benfari G., Beraldi M., Bergandi G., Bilardo G., Binno S. M., Bolognesi M., Bongiovi S., Bragato R. M., Braggion G., Brancaleoni R., Bursi F., Dessalvi C. C., Cameli M., Canu A., Capitelli M., Capra A. C. M., Carbonara R., Carbone M., Carbonella M., Carrabba N., Casavecchia G., Casula M., Chesi E., Cicco S., Citro R., Cocchia R., Colombo B. M., Colonna P., Conte M., Corrado G., Cortesi P., Cortigiani L., Costantino M. F., Cozza F., Cucchini U., D'Angelo M., Ros S. D., D'Andrea F., D'Andrea A., D'Auria F., De Caridi G., De Feo S., De Matteis G. M., De Vecchi S., Del Giudice C., Dell'Angela L., Delli Paoli L., Dentamaro I., Destefanis P., Di Fulvio M., Di Gaetano R., Di Giannuario G., Di Gioia A., Di Martino L. F. M., Di Muro C., Di Nora C., Di Salvo G., Dodi C., Dogliani S., Donati F., Dottori M., Epifani G., Fabiani I., Ferrara F., Ferrara L., Ferrua S., Filice G., Fiorino M., Forno D., Garini A., Giarratana G. A., Gigantino G., Giorgi M., Giubertoni E., Greco C. A., Grigolato M., Marra W. G., Holzl A., Iaiza A., Iannaccone A., Ilardi F., Imbalzano E., Inciardi R., Inserra C. A., Iori E., Izzo A., La Rosa G., Labanti G., Lanzone A. M., Lanzoni L., Lapetina O., Leiballi E., Librera M., Lo Conte C., Lo Monaco M., Lombardo A., Luciani M., Lusardi P., Magnante A., Malagoli A., Malatesta G., Mancusi C., Manes M. T., Manganelli F., Mantovani F., Manuppelli V., Marchese V., Marinacci L., Mattioli R., Maurizio C., Mazza G. A., Mazza S., Melis M., Meloni G., Merli E., Milan A., Minardi G., Monaco A., Monte I., Montresor G., Moreo A., Mori F., Morini S., Moro C., Morrone D., Negri F., Nipote C., Nisi F., Nocco S., Novello L., Nunziata L., Perini A. P., Parodi A., Pasanisi E. M., Pastorini G., Pavasini R., Pavoni D., Pedone C., Pelliccia F., Pelliciari G., Pelloni E., Pergola V., Perillo G., Petruccelli E., Pezzullo C., Piacentini G., Picardi E., Pinna G., Pizzarelli M., Pizzuti A., Poggi M. M., Posteraro A., Privitera C., Rampazzo D., Ratti C., Rettegno S., Ricci F., Ricci C., Rolando C., Rossi S., Rovera C., Ruggieri R., Russo M. G., Sacchi N., Saladino A., Sani F., Sartori C., Scarabeo V., Sciacqua A., Scillone A., Scopelliti P. A., Scorza A., Scozzafava A., Serafini F., Serra W., Severino S., Simeone B., Sirico D., Solari M., Spadaro G. L., Stefani L., Strangio A., Surace F. C., Tamborini G., Tarquinio N., Tassone E. J., Tavarozzi I., Tchana B., Tedesco G., Tinto M., Torzillo D., Totaro A., Triolo O. F., Troisi F., Tusa M., Vancheri F., Varasano V., Venezia A., Vermi A. C., Villari B., Zampi G., Zannoni J., Zito C., Zugaro A., Di Bella G., Carerj S., Ciampi, Q, Pepi, M, Antonini-Canterin, F, Barbieri, A, Barchitta, A, Faganello, G, Miceli, S, Parato, V, Tota, A, Trocino, G, Abbate, M, Accadia, M, Alemanni, R, Angelini, A, Anglano, F, Anselmi, M, Aquila, I, Aramu, S, Avogadri, E, Azzaro, G, Badano, L, Balducci, A, Ballocca, F, Barbarossa, A, Barbati, G, Barletta, V, Barone, D, Becherini, F, Benfari, G, Beraldi, M, Bergandi, G, Bilardo, G, Binno, S, Bolognesi, M, Bongiovi, S, Bragato, R, Braggion, G, Brancaleoni, R, Bursi, F, Dessalvi, C, Cameli, M, Canu, A, Capitelli, M, Capra, A, Carbonara, R, Carbone, M, Carbonella, M, Carrabba, N, Casavecchia, G, Casula, M, Chesi, E, Cicco, S, Citro, R, Cocchia, R, Colombo, B, Colonna, P, Conte, M, Corrado, G, Cortesi, P, Cortigiani, L, Costantino, M, Cozza, F, Cucchini, U, D'Angelo, M, Ros, S, D'Andrea, F, D'Andrea, A, D'Auria, F, De Caridi, G, De Feo, S, De Matteis, G, De Vecchi, S, Del Giudice, C, Dell'Angela, L, Delli Paoli, L, Dentamaro, I, Destefanis, P, Di Fulvio, M, Di Gaetano, R, Di Giannuario, G, Di Gioia, A, Di Martino, L, Di Muro, C, Di Nora, C, Di Salvo, G, Dodi, C, Dogliani, S, Donati, F, Dottori, M, Epifani, G, Fabiani, I, Ferrara, F, Ferrara, L, Ferrua, S, Filice, G, Fiorino, M, Forno, D, Garini, A, Giarratana, G, Gigantino, G, Giorgi, M, Giubertoni, E, Greco, C, Grigolato, M, Marra, W, Holzl, A, Iaiza, A, Iannaccone, A, Ilardi, F, Imbalzano, E, Inciardi, R, Inserra, C, Iori, E, Izzo, A, La Rosa, G, Labanti, G, Lanzone, A, Lanzoni, L, Lapetina, O, Leiballi, E, Librera, M, Lo Conte, C, Lo Monaco, M, Lombardo, A, Luciani, M, Lusardi, P, Magnante, A, Malagoli, A, Malatesta, G, Mancusi, C, Manes, M, Manganelli, F, Mantovani, F, Manuppelli, V, Marchese, V, Marinacci, L, Mattioli, R, Maurizio, C, Mazza, G, Mazza, S, Melis, M, Meloni, G, Merli, E, Milan, A, Minardi, G, Monaco, A, Monte, I, Montresor, G, Moreo, A, Mori, F, Morini, S, Moro, C, Morrone, D, Negri, F, Nipote, C, Nisi, F, Nocco, S, Novello, L, Nunziata, L, Perini, A, Parodi, A, Pasanisi, E, Pastorini, G, Pavasini, R, Pavoni, D, Pedone, C, Pelliccia, F, Pelliciari, G, Pelloni, E, Pergola, V, Perillo, G, Petruccelli, E, Pezzullo, C, Piacentini, G, Picardi, E, Pinna, G, Pizzarelli, M, Pizzuti, A, Poggi, M, Posteraro, A, Privitera, C, Rampazzo, D, Ratti, C, Rettegno, S, Ricci, F, Ricci, C, Rolando, C, Rossi, S, Rovera, C, Ruggieri, R, Russo, M, Sacchi, N, Saladino, A, Sani, F, Sartori, C, Scarabeo, V, Sciacqua, A, Scillone, A, Scopelliti, P, Scorza, A, Scozzafava, A, Serafini, F, Serra, W, Severino, S, Simeone, B, Sirico, D, Solari, M, Spadaro, G, Stefani, L, Strangio, A, Surace, F, Tamborini, G, Tarquinio, N, Tassone, E, Tavarozzi, I, Tchana, B, Tedesco, G, Tinto, M, Torzillo, D, Totaro, A, Triolo, O, Troisi, F, Tusa, M, Vancheri, F, Varasano, V, Venezia, A, Vermi, A, Villari, B, Zampi, G, Zannoni, J, Zito, C, Zugaro, A, Di Bella, G, Carerj, S, Ciampi Q., Pepi M., Antonini-Canterin F., Barbieri A., Barchitta A., Faganello G., Miceli S., Parato V. M., Tota A., Trocino G., Abbate M., Accadia M., Alemanni R., Angelini A., Anglano F., Anselmi M., Aquila I., Aramu S., Avogadri E., Azzaro G., Badano L., Balducci A., Ballocca F., Barbarossa A., Barbati G., Barletta V., Barone D., Becherini F., Benfari G., Beraldi M., Bergandi G., Bilardo G., Binno S. M., Bolognesi M., Bongiovi S., Bragato R. M., Braggion G., Brancaleoni R., Bursi F., Dessalvi C. C., Cameli M., Canu A., Capitelli M., Capra A. C. M., Carbonara R., Carbone M., Carbonella M., Carrabba N., Casavecchia G., Casula M., Chesi E., Cicco S., Citro R., Cocchia R., Colombo B. M., Colonna P., Conte M., Corrado G., Cortesi P., Cortigiani L., Costantino M. F., Cozza F., Cucchini U., D'Angelo M., Ros S. D., D'Andrea F., D'Andrea A., D'Auria F., De Caridi G., De Feo S., De Matteis G. M., De Vecchi S., Del Giudice C., Dell'Angela L., Delli Paoli L., Dentamaro I., Destefanis P., Di Fulvio M., Di Gaetano R., Di Giannuario G., Di Gioia A., Di Martino L. F. M., Di Muro C., Di Nora C., Di Salvo G., Dodi C., Dogliani S., Donati F., Dottori M., Epifani G., Fabiani I., Ferrara F., Ferrara L., Ferrua S., Filice G., Fiorino M., Forno D., Garini A., Giarratana G. A., Gigantino G., Giorgi M., Giubertoni E., Greco C. A., Grigolato M., Marra W. G., Holzl A., Iaiza A., Iannaccone A., Ilardi F., Imbalzano E., Inciardi R., Inserra C. A., Iori E., Izzo A., La Rosa G., Labanti G., Lanzone A. M., Lanzoni L., Lapetina O., Leiballi E., Librera M., Lo Conte C., Lo Monaco M., Lombardo A., Luciani M., Lusardi P., Magnante A., Malagoli A., Malatesta G., Mancusi C., Manes M. T., Manganelli F., Mantovani F., Manuppelli V., Marchese V., Marinacci L., Mattioli R., Maurizio C., Mazza G. A., Mazza S., Melis M., Meloni G., Merli E., Milan A., Minardi G., Monaco A., Monte I., Montresor G., Moreo A., Mori F., Morini S., Moro C., Morrone D., Negri F., Nipote C., Nisi F., Nocco S., Novello L., Nunziata L., Perini A. P., Parodi A., Pasanisi E. M., Pastorini G., Pavasini R., Pavoni D., Pedone C., Pelliccia F., Pelliciari G., Pelloni E., Pergola V., Perillo G., Petruccelli E., Pezzullo C., Piacentini G., Picardi E., Pinna G., Pizzarelli M., Pizzuti A., Poggi M. M., Posteraro A., Privitera C., Rampazzo D., Ratti C., Rettegno S., Ricci F., Ricci C., Rolando C., Rossi S., Rovera C., Ruggieri R., Russo M. G., Sacchi N., Saladino A., Sani F., Sartori C., Scarabeo V., Sciacqua A., Scillone A., Scopelliti P. A., Scorza A., Scozzafava A., Serafini F., Serra W., Severino S., Simeone B., Sirico D., Solari M., Spadaro G. L., Stefani L., Strangio A., Surace F. C., Tamborini G., Tarquinio N., Tassone E. J., Tavarozzi I., Tchana B., Tedesco G., Tinto M., Torzillo D., Totaro A., Triolo O. F., Troisi F., Tusa M., Vancheri F., Varasano V., Venezia A., Vermi A. C., Villari B., Zampi G., Zannoni J., Zito C., Zugaro A., Di Bella G., and Carerj S.

Abstract

Background: The Italian Society of Echocardiography and Cardiovascular Imaging (SIECVI) conducted a national survey to understand better how different echocardiographic modalities are used and accessed in Italy. Methods: We analyzed echocardiography laboratory activities over a month (November 2022). Data were retrieved via an electronic survey based on a structured questionnaire, uploaded on the SIECVI website. Results: Data were obtained from 228 echocardiographic laboratories: 112 centers (49%) in the northern, 43 centers (19%) in the central, and 73 (32%) in the southern regions. During the month of observation, we collected 101,050 transthoracic echocardiography (TTE) examinations performed in all centers. As concern other modalities there were performed 5497 transesophageal echocardiography (TEE) examinations in 161/228 centers (71%); 4057 stress echocardiography (SE) examinations in 179/228 centers (79%); and examinations with ultrasound contrast agents (UCAs) in 151/228 centers (66%). We did not find significant regional variations between the different modalities. The usage of picture archiving and communication system (PACS) was significantly higher in the northern (84%) versus central (49%) and southern (45%) centers (P < 0.001). Lung ultrasound (LUS) was performed in 154 centers (66%), without difference between cardiology and noncardiology centers. The evaluation of left ventricular (LV) ejection fraction was evaluated mainly using the qualitative method in 223 centers (94%), occasionally with the Simpson method in 193 centers (85%), and with selective use of the three-dimensional (3D) method in only 23 centers (10%). 3D TTE was present in 137 centers (70%), and 3D TEE in all centers where TEE was done (71%). The assessment of LV diastolic function was done routinely in 80% of the centers. Right ventricular function was evaluated using tricuspid annular plane systolic excursion in all centers, using tricuspid valve annular systolic velocity by tissue

Published
2023

4. Stress echocardiography: application of the ABCDE protocol in patients with permanent atrial fibrillation

Author

Barbieri, A, primary, Bursi, F, additional, Ciampi, Q, additional, Cortigiani, L, additional, Zanella, H, additional, Wierzbowska-Drabik, K, additional, Kasprszak, J D, additional, Arbucci, R, additional, Zagatina, A, additional, Mantovani, F, additional, Bartolacelli, Y, additional, Carerj, S, additional, Pepi, M, additional, Pellika, P A, additional, and Picano, E, additional

Published
2023
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11. Multimodality imaging to assess severity and outcome in asymptomatic patients with aortic stenosis: a medium-long term follow-up study

Author

Zito, C, primary, Manganaro, R, additional, De Sarro, R, additional, Licordari, R, additional, Bursi, F, additional, Mantovani, F, additional, Benfari, G, additional, Malagoli, A, additional, Bertolacelli, Y, additional, D'Angelo, T, additional, Antonini-Canterin, F, additional, Carerj, S, additional, and Barbieri, A, additional

Published
2022
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13. Stress echo 2030: The novel ABCDE-(FGLPR) protocol to define the future of imaging

Author

Picano E, Ciampi Q, Cortigiani L, Arruda-Olson AM, Borguezan-Daros C, de Castro E Silva Pretto JL, Cocchia R, Bossone E, Merli E, Kane GC, Varga A, Agoston G, Scali MC, Morrone D, Simova I, Samardjieva M, Boshchenko A, Ryabova T, Vrublevsky A, Palinkas A, Palinkas ED, Sepp R, Torres MAR, Villarraga HR, Preradović TK, Citro R, Amor M, Mosto H, Salamè M, Leeson P, Mangia C, Gaibazzi N, Tuttolomondo D, Prota C, Peteiro J, Van De Heyning CM, D'Andrea A, Rigo F, Nikolic A, Ostojic M, Lowenstein J, Arbucci R, Haber DML, Merlo PM, Wierzbowska-Drabik K, Kasprzak JD, Haberka M, Camarozano AC, Ratanasit N, Mori F, D'Alfonso MG, Tassetti L, Milazzo A, Olivotto I, Marchi A, Rodriguez-Zanella H, Zagatina A, Padang R, Dekleva M, Djordievic-Dikic A, Boskovic N, Tesic M, Giga V, Beleslin B, Di Salvo G, Lorenzoni V, Cameli M, Mandoli GE, Bombardini T, Caso P, Celutkiene J, Barbieri A, Benfari G, Bartolacelli Y, Malagoli A, Bursi F, Mantovani F, Villari B, Russo A, De Nes M, Carpeggiani C, Monte I, Re F, Cotrim C, Bilardo G, Saad AK, Karuzas A, Matuliauskas D, Colonna P, Antonini-Canterin F, Pepi M, Pellikka PA, The Stress Echo Study Group Of The Italian Society Of Echocardiography And Cardiovascular Imaging Siecvi., Picano, E, Ciampi, Q, Cortigiani, L, Arruda-Olson, Am, Borguezan-Daros, C, de Castro, E Silva Pretto JL, Cocchia, R, Bossone, E, Merli, E, Kane, Gc, Varga, A, Agoston, G, Scali, Mc, Morrone, D, Simova, I, Samardjieva, M, Boshchenko, A, Ryabova, T, Vrublevsky, A, Palinkas, A, Palinkas, Ed, Sepp, R, Torres, Mar, Villarraga, Hr, Preradović, Tk, Citro, R, Amor, M, Mosto, H, Salamè, M, Leeson, P, Mangia, C, Gaibazzi, N, Tuttolomondo, D, Prota, C, Peteiro, J, Van De Heyning, Cm, D'Andrea, A, Rigo, F, Nikolic, A, Ostojic, M, Lowenstein, J, Arbucci, R, Haber, Dml, Merlo, Pm, Wierzbowska-Drabik, K, Kasprzak, Jd, Haberka, M, Camarozano, Ac, Ratanasit, N, Mori, F, D'Alfonso, Mg, Tassetti, L, Milazzo, A, Olivotto, I, Marchi, A, Rodriguez-Zanella, H, Zagatina, A, Padang, R, Dekleva, M, Djordievic-Dikic, A, Boskovic, N, Tesic, M, Giga, V, Beleslin, B, Di Salvo, G, Lorenzoni, V, Cameli, M, Mandoli, Ge, Bombardini, T, Caso, P, Celutkiene, J, Barbieri, A, Benfari, G, Bartolacelli, Y, Malagoli, A, Bursi, F, Mantovani, F, Villari, B, Russo, A, De Nes, M, Carpeggiani, C, Monte, I, Re, F, Cotrim, C, Bilardo, G, Saad, Ak, Karuzas, A, Matuliauskas, D, Colonna, P, Antonini-Canterin, F, Pepi, M, Pellikka, Pa, The Stress Echo Study Group Of The Italian Society Of Echocardiography And Cardiovascular Imaging, Siecvi., and The Stress Echo 2030 Study Group of the Italian Society of Echocardiography and Cardiovascular Imaging (SIECVI)

Subjects
medicine.medical_specialty, Registry, Functional testing, Effectiveness, 030204 cardiovascular system & hematology, Article, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Stress Echocardiography, echocardiography, 030212 general & internal medicine, Tetralogy of Fallot, business.industry, valvular heart disease, Diastolic heart failure, Hypertrophic cardiomyopathy, COVID-19, Stress echocardiography, Sustainability, General Medicine, medicine.disease, 3. Good health, effectiveness, registry, stress echocardiography, sustainability, Coronary vasospasm, Cardiology, Medicine, Human medicine, business, effectivene
Abstract

With stress echo (SE) 2020 study, a new standard of practice in stress imaging was developed and disseminated: the ABCDE protocol for functional testing within and beyond CAD. ABCDE protocol was the fruit of SE 2020, and is the seed of SE 2030, which is articulated in 12 projects: 1-SE in coronary artery disease (SECAD), 2-SE in diastolic heart failure (SEDIA), 3-SE in hypertrophic cardiomyopathy (SEHCA), 4-SE post-chest radiotherapy and chemotherapy (SERA), 5-Artificial intelligence SE evaluation (AI-SEE), 6-Environmental stress echocardiography and air pollution (ESTER), 7-SE in repaired Tetralogy of Fallot (SETOF), 8-SE in post-COVID-19 (SECOV), 9: Recovery by stress echo of conventionally unfit donor good hearts (RESURGE), 10-SE for mitral ischemic regurgitation (SEMIR), 11-SE in valvular heart disease (SEVA), 12-SE for coronary vasospasm (SESPASM). The study aims to recruit in the next 5 years (2021–2025) ≥10,000 patients followed for ≥5 years (up to 2030) from ≥20 quality-controlled laboratories from ≥10 countries. In this COVID-19 era of sustainable health care delivery, SE2030 will provide the evidence to finally recommend SE as the optimal and versatile imaging modality for functional testing anywhere, any time, and in any patient.

Published
2021

24. Prognostic and therapeutic implications of pulmonary hypertension complicating degenerative mitral regurgitation due to flail leaflet: A Multicenter Long-term International Study

Author

Barbieri, Andrea, Bursi, Francesca, Grigioni, Francesco, Tribouilloy, Christophe, Avierinos, Jean Francois, Michelena, Hector I., Rusinaru, Dan, Szymansky, Catherine, Russo, Antonio, Suri, Rakesh, Bacchi Reggiani, Maria Letizia, Branzi, Angelo, Modena, Maria Grazia, Enriquez-Sarano, Maurice, Tribouilloy, C., Rusinaru, D., Szymanski, C., Fournier, A., Trojette, F., Touati, G., Remadi, J. P., Grigioni, F., Russo, A., Piovaccari, G., Ferlito, M., Ionico, T., Barbaresi, E., Branzi, A., Savini, C., Martin-Suarez, S., Marinelli, G., Di Bartolomeo, R., Avierinos, J. F., Tafanelli, L., Habib, G., Collard, F., Riberi, A., Metras, D., Barbieri, A., Bursi, F., Grimaldi, T., Nuzzo, A., Modena, M. G., Enriquez-Sarano, M., Michelena, H. I., Suri, R., and Bacchi-Reggiani, M. L.

Published
2011
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25. UNRAVELING GENDER DISPARITIES AND PROGNOSTIC INSIGHTS IN MODERATE AORTIC STENOSIS: A RETROSPECTIVE STUDY

Author

Guareschi, A, Donisi, L, Pasero, G, Mallardi, G, Faggiano, A, Faggiano, P, Bursi, F, Santangelo, G, and Carugo, S

Abstract

Aortic stenosis (AS) is the most prevalent valvular heart disease in developed countries, associated with reduced survival if severe AS remains untreated. Recent reports note unfavorable outcomes in moderate AS (mAS) patients, challenging optimal intervention timing. Variations in pathophysiology linked to sex differences, involving sex hormones, activation of the renin–angiotensin–aldosterone system, and dysregulation in collagen synthesis, have been observed. Yet, limited data exists on sex–specific differences in mAS outcomes. This single–center, retrospective study included 150 patients (median age 79±13 years, female sex 48%) diagnosed with mAS who underwent comprehensive echocardiography in IRCCS Fondazione Ca’ Granda Ospedale Maggiore Policlinico of Milan from July 2022 to October 2023. Clinical data, encompassing demographics details and therapy, were obtained via record reviews and phone interviews. Death verification relied on the ‘Sistema Informativo Socio–Sanitario Regione Lombardia’ database. Echocardiographic records were digitally stored and post–processed by four independent investigators using Medimatic ComPACS workstation. Men were significantly younger than women (75±10 vs 79±9.7 years, p= 0.016). They exhibited lower left ventricular (LV) ejection fraction, larger LV end–systolic volume and stroke volume compared to women (54±7 vs 59±10%; p=0.028. 55±36 vs 31±13 ml; p<0.001. 83±18 vs 75±18 ml; p=0.030). Men had significantly smaller aortic valve (AV) area index to body surface area (BSA) (0.6±0.09 vs 0.7±0.1 cmq/mq; p<0.001) and lower doppler velocity index (0.32±0.07 vs 0.38±0.11; p<0.001) than women. Coronary artery disease and smoking were more frequent in men (53.3 vs 46.7%; p=0,002. 52.6 vs 47.4%; p<0.001). In survival analysis, 15% of women and 30.8% of men experienced events, with male gender independently associated with the composite outcome (all–cause mortality and AV replacement) over a mean follow–up time of 200 ± 133 days, showing a median survival of 244±16 vs 255±15 days for females (p–value=0.025). In multivariable analysis including relevant clinical variables (hemoglobin and AV index to BSA), male sex remained independently associated with the composite outcome (hazard ratio 2,01; CI 1.0–4.17; p=0.05). Women diagnosed with mAS exhibited a lower incidence of AV replacement and all–cause mortality. These findings may suggest the existence of different clinical and echocardiographic phenotypes among patients with AS.

Published
2024
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27. Long-Term Implications of Atrial Fibrillation in Patients With Degenerative Mitral Regurgitation

Author

Grigioni, Francesco, primary, Benfari, Giovanni, additional, Vanoverschelde, Jean-Louis, additional, Tribouilloy, Christophe, additional, Avierinos, Jean-Francois, additional, Bursi, Francesca, additional, Suri, Rakesh M., additional, Guerra, Federico, additional, Pasquet, Agnés, additional, Rusinaru, Dan, additional, Marcelli, Emanuela, additional, Théron, Alexis, additional, Barbieri, Andrea, additional, Michelena, Hector, additional, Lazam, Siham, additional, Szymanski, Catherine, additional, Nkomo, Vuyisile T., additional, Capucci, Alessandro, additional, Thapa, Prabin, additional, Enriquez-Sarano, Maurice, additional, Suri, R., additional, Clavel, M.A, additional, Maalouf, J., additional, Michelena, H., additional, Enriquez-Sarano, M., additional, Tribouilloy, C., additional, Trojette, F., additional, Szymanski, C., additional, Rusinaru, D., additional, Touati, G., additional, Remadi, J.P., additional, Guerra, F., additional, Capucci, A., additional, Grigioni, F., additional, Russo, A., additional, Biagini, E., additional, Pasquale, F., additional, Ferlito, M., additional, Rapezzi, C., additional, Savini, C., additional, Marinelli, G., additional, Pacini, D., additional, Gargiulo, G.D., additional, Di Bartolomeo, R., additional, Boulif, J., additional, de Meester, C., additional, El Khoury, G., additional, Gerber, B., additional, Lazam, S., additional, Pasquet, A., additional, Noirhomme, P., additional, Vancraeynest, D., additional, Vanoverschelde, J-L., additional, Avierinos, J.F., additional, Collard, F., additional, Théron, A., additional, Habib, G., additional, Barbieri, A., additional, Bursi, F., additional, Mantovani, F., additional, Lugli, R., additional, Modena, M.G., additional, Boriani, G., additional, and Bacchi-Reggiani, L., additional

Published
2019
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28. Impact of ageing on presentation and outcome of mitral regurgitation due to flail leaflet: a multicentre international study

Author

Avierinos, J. -F., Tribouilloy, C., Grigioni, F., Suri, R., Barbieri, A., Michelena, H. I., Ionico, T., Rusinaru, D., Ansaldi, S., Habib, G., Szymanski, C., Giorgi, R., Mahoney, D. W., Enriquez-Sarano, M., Theron, A., Riberi, A., Collard, F., Touati, G., Remadi, J. P., Caus, T., Barbaresi, E., Russo, A., Biagini, E., Piovaccari, G., Ferlito, M., Branzi, A., Savini, C., Marinelli, G., Petridis, F., Di Bartolomeo, R., Bursi, F., Grimaldi, T., Nuzzo, A., Modena, M. G., J.-F. Avierino, C. Tribouilloy, F. Grigioni, R. Suri, A. Barbieri, H. I. Michelena, T. Ionico, D. Rusinaru, S. Ansaldi, G. Habib, C. Szymanski, R. Giorgi, D. W. Mahoney, and M. Enriquez-Sarano

Subjects
Congestive heart failure, Male, medicine.medical_specialty, Population, Mitral valve surgery, ATRIAL FIBRILLATION, Risk Factors, Internal medicine, Humans, Medicine, Registries, education, Outcome, Aged, Mitral regurgitation, Heart Failure, education.field_of_study, Ageing, Atrial fibrillation, business.industry, Age Factors, Absolute risk reduction, Mitral Valve Insufficiency, Middle Aged, Prognosis, medicine.disease, Comorbidity, Confidence interval, congestive heart failure, Echocardiography, Heart failure, Relative risk, Cardiology, Female, Cardiology and Cardiovascular Medicine, business
Abstract

Aims Define the impact of age at diagnosis on degenerative mitral regurgitation (MR) prognosis. Methods and results The Mitral regurgitation International DAtabase (MIDA) is a multicentre registry of MR due to flail leaflets including 862 patients (65 ± 12 years) diagnosed by echocardiography. The 498 older patients (≥65 years at diagnosis) were compared with the 364 younger (

Published
2013
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29. Outcomes penalty linked to female gender in severe primary mitral regurgitation due to flail leaflet

Author

Pradier, J., Theron, A., Resseguier, N., Grigioni, F., Tribouilloy, Christophe, Habib, G., Vanoverschelde, J. -L., Bursi, F., Enriquez-Sarano, M., Avierinos, J. F., DESSAIVRE, Louise, Département d'hématologie biologique[Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Saint Eloi (CHRU Montpellier), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Hôpital de la Timone [CHU - APHM] (TIMONE), CHU Amiens-Picardie, Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Service de cardiologie, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), and Mayo Clinic [Rochester]

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2017

32. On the modeling of line feeding systems with bin-kanban and logistic trains as polling systems

Author

Bursi, F., Gebennini, E., Andrea Grassi, Rimini, B., Bursi, Fabio, Gebennini, Elisa, Grassi, Andrea, and Rimini, Bianca

Subjects
Bin-kanban, Mixed-model assembly lines, Polling systems, Bin-kanban, Mixed-model assembly lines, Polling systems
Abstract

This paper deals with the part supply process in a mixed-model assembly line served by a logistic train. The logistic train periodically follows a fixed route (tour) and, in each tour, it visits all the stations for providing full bins of parts and retrieving the empty bins (which will be re-filled in a "supermarket" at the end of the tour). The aim of this paper is to analytically model such a system in order to support the dimensioning of both the logistic train and the station buffers. The innovative contribution consists in treating the system as a "polling system", i.e., a set of queues attended by a single server. This allows us to consider the variability of the station cycle times and the tour duration of the logistic train. In particular, since the capacity of the logistic train is constrained by the number of wagons, the study generalizes approaches for the uncapacitated-server polling systems to the capacitated case.

Published
2015

34. Survival Implication of Left Ventricular End-Systolic Diameter in Mitral Regurgitation Due to Flail Leaflets. A Long-Term Follow-Up Multicenter Study

Author

Tribouilloy, C, Grigioni, F, Avierinos, Jf, Barbieri, A, Rusinaru, D, Szymanski, C, Ferlito, M, Tafanelli, L, Bursi, F, Trojette, F, Branzi, A, Habib, G, Modena, Maria Grazia, Enriquez Sarano, M, Investigators, Mida, Tribouilloy C, Grigioni F, Avierinos JF, Barbieri A, Rusinaru D, Szymanski C, Ferlito M, Tafanelli L, Bursi F, Trojette F, Branzi A, Habib G, Modena MG, and Enriquez-Sarano

Subjects
Male, Time Factors, Systole, Heart Ventricles, Mitral Valve Insufficiency, Middle Aged, flail, Prognosis, Myocardial Contraction, mitral regurgitation, Echocardiography, Doppler, Ventricular Function, Left, Europe, Survival Rate, Confidence Intervals, Odds Ratio, Humans, Female, Aged, Follow-Up Studies, Retrospective Studies
Abstract

This study analyzed the association of left ventricular end-systolic diameter (LVESD) with survival after diagnosis in organic mitral regurgitation (MR) due to flail leaflets.LVESD is a marker of left ventricular function in patients with organic MR but its association to survival after diagnosis is unknown.The MIDA (Mitral Regurgitation International Database) registry is a multicenter registry of echocardiographically diagnosed organic MR due to flail leaflets. We enrolled 739 patients with MR due to flail leaflets (age 65 +/- 12 years; ejection fraction: 65 +/- 10%) in whom LVESD was measured (36 +/- 7 mm).Under conservative management, 10-year survival and survival free of cardiac death were higher with LVESD40 mm versusor =40 mm (64 +/- 5% vs. 48 +/- 10%; p0.001, and 73 +/- 5% vs. 63 +/- 10%; p = 0.001). LVESDor =40 mm independently predicted overall mortality (hazard ratio [HR]: 1.95, 95% confidence interval [CI]: 1.01 to 3.83) and cardiac mortality (HR: 3.09, 95% CI: 1.35 to 7.09) under conservative management. Mortality risk increased linearly with LVESD40 mm (HR: 1.15, 95% CI: 1.04 to 1.27 per 1-mm increment). During the entire follow-up (including post-surgical), LVESDor =40 mm independently predicted overall mortality (HR: 1.86, 95% CI: 1.24 to 2.80) and cardiac mortality (HR: 2.14, 95% CI: 1.29 to 3.56), due to persistence of excess mortality in patients with LVESDor =40 mm after surgery (HR: 1.86, 95% CI: 1.11 to 3.15 for overall death, and HR: 1.81, 95% CI: 1.05 to 3.54 for cardiac death).In MR due to flail leaflets, LVESDor =40 mm is independently associated with increased mortality under medical management but also after mitral surgery. These findings support prompt surgical rescue in patients with LVESDor =40 mm but also suggest that best preservation of survival is achieved in patients operated before LVESD reaches 40 mm.

Published
2009

35. Twenty-Year Outcome After Mitral Repair Versus Replacement for Severe Degenerative Mitral Regurgitation

Author

Lazam, Siham, primary, Vanoverschelde, Jean-Louis, additional, Tribouilloy, Christophe, additional, Grigioni, Francesco, additional, Suri, Rakesh M., additional, Avierinos, Jean-Francois, additional, de Meester, Christophe, additional, Barbieri, Andrea, additional, Rusinaru, Dan, additional, Russo, Antonio, additional, Pasquet, Agnès, additional, Michelena, Hector I., additional, Huebner, Marianne, additional, Maalouf, Joseph, additional, Clavel, Marie-Annick, additional, Szymanski, Catherine, additional, Enriquez-Sarano, Maurice, additional, Michelina, H., additional, Poulain, H., additional, Remadi, J.-P., additional, Touati, G., additional, Trojette, F., additional, Biagini, E., additional, Di Bartolomeo, R., additional, Ferlito, F.M., additional, Marinelli, G., additional, Pacini, D., additional, Pasquale, F., additional, Rapezzi, C., additional, Savini, C., additional, Boulif, J., additional, El Khoury, G., additional, Gerber, B., additional, Noirhomme, P., additional, Vancraeynest, D., additional, Collard, F., additional, Habib, G., additional, Metras, D., additional, Riberi, A., additional, Tafanelli, L., additional, Bursi, F., additional, Lugli, R., additional, Mantovani, F., additional, Manicardi, C., additional, Grazia, M., additional, and Bacchi-Reggiani, L., additional

Published
2017
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36. P210Long- term outcome of primary mitral valve prolapse: results from a population of 250 patients referred to a tertiary cardiovascular center.P211Rheumatic Heart Disease in Uganda - Results from more than 600 echocardiograms in a no-profit hospitalP212Higher ventricular ectopy burden in asymptomatic severe Barlows mitral valve disease compared to similar patients with mitral valve prolapseP213Surgical mitral valve repair for severe secondary mitral regurgitation: prognostic implications of left ventricular forward flowP214Multicentre trial results of a transfemoral annuloplasty system for mitral valve reconstruction -P215Comparative assessment of paravalvular leaks with 3D-transesophageal echocardiography and cardiac computed tomographyP216Failing surgical aortic bioprosthetic valves: redo aortic valve surgery versus percutaneous valve-in-valve replacementP217Mitral annular calcification and infective endocarditisP218Infective endocarditis - a changing diseaseP219Staphilococcus aureus bacteremia: application of the ESC proposed diagnostic echocardiographic algorithm in clinical practiceP220ESC proposed diagnostic echocardiographic algorithm in elective patients with clinical suspicion of infective endocarditis and negative blood cultures: diagnostic yield and prognostic implicationsP221Three-dimensional transesophageal echocardiography versus multidetector computed tomography for aortic annulus sizing in TAVI: a worthy alternativeP222Early and mid-term improvement in left ventricular function after transcatheter aortic valve replacement as assessed by myocardial strain imagingP223Dynamic of aortic root as predictor of paravalvular regurgitation after transcatheter aortic valve implantationP224Short term effect of heart rate reduction by Ivabradine on left ventricular function and remodeling in systolic heart failure patientsP225Global longitudinal strain and regional longitudinal strain in patients with hypertrophic cardiomyopathy: are they associated with the presence of myocardial fibrosis?P226Investigation of mitral leaflet elongation in patients with non-obstructive versus latent-obstructive hypertrophic cardiomyopathyP227Hypertrophic cardiomyopathy: to what degree have the new ESC guidelines been implemented in routine clinical practice? A retrospective audit assessing current practice in a large general UK hospitalP228New genotype-phenotype associations in hypertrophic cardiomyopathy patients studied with cardiac magnetic resonance with feature-trackingP229How many are too many - frequent premature ventricular contractions and left ventricular functionP230Two-dimensional global longitudinal strain and strain rate for evaluation of inflammatory cardiomyopathy as proven by endomyocardial biopsyP231The echocardiographic features of young asymptomatic screening population with left ventricular hypertrabeculationP232Use of amlodipine to decrease myocardial iron in thalassemia major (AMIT trial): comparison of T2* CMR and echocardiography for assessment of cardiac volumes and functionP233Echocardiographic comparison of Fabry cardiomyopathy and light-chain amyloid heart diseaseP234Early detection of left atrial enlargement using 3D echocardiography in patients undergoing breast cancer treatment

Author

Mecarocci, V., primary, Mapelli, M., primary, Johnson, K., primary, Kamperidis, V., primary, Treede, H., primary, Alonso Fernandez De Gatta, M., primary, Mameri, A., primary, Pressman, G., primary, Coutinho Cruz, M., primary, Bartolacelli, Y., primary, Gillebert, C., primary, Lozano-Granero, VC., primary, Boretti, I., primary, Son, JW., primary, Carvalho, JF., primary, Zuo, L., primary, Basu, J., primary, Gomes, AC., primary, Lie, OH., primary, Aleksandrov, AS., primary, Tang, HC., primary, Alvi, N., primary, Marek, J., primary, Rascon Sabido, R., primary, Mori, F., additional, Fusini, L., additional, Zagni, P., additional, Muratori, M., additional, Agostoni, P., additional, Gripari, P., additional, Ghulam Ali, S., additional, Tamborini, G., additional, Pepi, M., additional, Fiorentini, C., additional, Abdel-Rahman, ST., additional, Dobson, L., additional, Kidambi, A., additional, Gatenby, K., additional, Schlosshan, D., additional, Van Wijngaarden, SE., additional, Van Rosendael, PJ., additional, Kong Kok Fai, W., additional, Leung, M., additional, Sianos, G., additional, Ajmone Marsan, N., additional, Bax, JJ., additional, Delgado, V., additional, Nickenig, G., additional, Kuck, KH., additional, Baldus, S., additional, Vahanian, A., additional, Colombo, A., additional, Alfieri, O., additional, Topilsky, Y., additional, Grayburn, P., additional, Maisano, F., additional, Barreiro Perez, M., additional, Arribas Jimenez, A., additional, Martin Garcia, A., additional, Diaz Pelaez, E., additional, Rodriguez Collado, J., additional, Cruz Gonzalez, I., additional, Sanchez Fernandez, PL., additional, Urena Alcazar, M., additional, Cimadevilla, C., additional, Himbert, D., additional, Raffoul, R., additional, Verdonk, C., additional, Nataf, P., additional, Messika-Zeitoun, D., additional, Gartman, CH., additional, Obasare, E., additional, Melendres, E., additional, Malik, M., additional, Slipczuk, L., additional, Figueredo, V., additional, Ilhao Moreira, R., additional, Moura Branco, L., additional, Galrinho, A., additional, Coutinho Miranda, L., additional, Timoteo, AT., additional, Abreu, J., additional, Pinto Teixeira, P., additional, Fragata, J., additional, Cruz Ferreira, R., additional, Barbieri, A., additional, Bursi, F., additional, Mantovani, F., additional, Lugli, R., additional, Fabbri, M., additional, Mussini, C., additional, Boriani, G., additional, Perry, R., additional, Hecker, T., additional, Szpytma, M., additional, Joseph, M., additional, Fernandez-Santos, S., additional, Plaza-Martin, M., additional, Lopez-Fernandez, T., additional, De La Hera, JM., additional, Martinez-Monzonis, A., additional, La Canna, G., additional, Mesa, D., additional, Swaans, M., additional, Murzilli, R., additional, Echevarria, T., additional, Habib, G., additional, Zamorano, JL., additional, Fernandez-Golfin Loban, C., additional, Salido, L., additional, Gonzalez Gomez, A., additional, Garcia Martin, A., additional, Hinojar Baides, R., additional, Pardo, A., additional, Moya Mur, JL., additional, Ruiz Leria, S., additional, Hernandez Antolin, R., additional, Jimenez Nacher, JJ., additional, Zamorano Gomez, JL., additional, Kim, HJ., additional, Kim, BJ., additional, Choi, KW., additional, Lee, CH., additional, Kim, W., additional, Park, JS., additional, Shin, DG., additional, Kim, YJ., additional, Choi, JH., additional, Congo, K., additional, Neves, D., additional, Pais, J., additional, Guerreiro, R., additional, Picarra, B., additional, Santos, AR., additional, Bento, A., additional, Aguiar, J., additional, Wang, J., additional, Ta, SJ., additional, Kang, N., additional, Zhou, MY., additional, Guo, RQ., additional, Liu, L., additional, Thorsen, L., additional, Thomas, K., additional, Shabbir, A., additional, Balkhausen, K., additional, Bull, S., additional, Lopes, LR., additional, Cruz, I., additional, Almeida, AR., additional, Pereira, H., additional, Saberniak, J., additional, Dejgaard, LA., additional, Anfinsen, OG., additional, Hegbom, F., additional, Edvardsen, T., additional, Haugaa, KH., additional, Kasner, M., additional, Tschoepe, C., additional, Ho, JS., additional, Goh, LK., additional, Ding, ZP., additional, Tipoo, FA., additional, Chowdhury, D., additional, Colan, S., additional, Imran, A., additional, Raza, U., additional, Ashiqali, S., additional, Hasan, BS., additional, Mohty, D., additional, Palecek, T., additional, Golan, L., additional, Jaccard, A., additional, Lenhart, A., additional, Garcia Mendez Rosalba, RGM, additional, Martinez Hernandez Carlos, MHC, additional, Ibarra Quevedo David, DIQ, additional, and Almeida Gutierrez Eduardo, EAG, additional

Published
2016
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37. On the generalization of continuous-time stochastic processes simulation for industrial production modeling

Author

Bursi, F., Ferrara, A., Andrea Grassi, Ronzoni, C., Bursi, Fabio, Ferrara, Andrea, Grassi, Andrea, and Ronzoni, Chiara

Subjects
Manufacturing system, Continuous time, Production flow, DEVS, Discrete event simulation, Continuous time, DEVS, Discrete event simulation, Manufacturing system, Production flow
Abstract

The paper presents a new generalized framework for carrying out simulations of continuous-time stochastic processes by exploiting a discrete event approach. The application scope of this work mainly refers to industrial production processes executed on a continuous flow of material (e.g., food and beverage industry) as well as production processes working on discrete units but characterized by a high production rate (e.g., automated packaging lines). The proposed model extends a previous work of the same Authors by introducing the capability to manage logical signals between couples of simulation units. In this way, control policies can be modeled and triggered by variations on parameters under monitoring during the simulation. A generalized model for a generic simulation unit is then presented and described adopting the DEVS formalism.

Published
2014

39. Prognostic value of troponin and creatine kinase muscle and brain isoenzyme measurement after noncardiac surgery: a systematic review and meta-analysis

Author

Levy, M, Heels-Ansdell, D, Hiralal, R, Bhandari, M, Guyatt, G, Yusuf, S, Cook, D, Villar, JC, McQueen, M, McFalls, E, Filipovic, M, Schunemann, H, Sear, J, Foex, P, Lim, W, Landesberg, G, Godet, G, Poldermans, D, Bursi, F, Kertai, MD, Bhatnagar, N, Devereaux, PJ, Anesthesiology, and Cardiology

Subjects
Cardiovascular Diseases, Surgical Procedures, Operative, Creatine Kinase, MB Form, Humans, Prognosis, Biomarkers, Troponin
Abstract

Background: There is uncertainty regarding the prognostic value of troponin and creatine kinase muscle and brain isoenzyme measurements after noncardiac surgery. Methods: The current study undertook a systematic review and meta-analysis. The study used six search strategies and included noncardiac surgery studies that provided data from a multivariable analysis assessing whether a postoperative troponin or creatine kinase muscle and brain isoenzyme measurement was an independent predictor of mortality or a major cardiovascular event. Independent investigators determined study eligibility and abstracted data in duplicate. Results: Fourteen studies, enrolling 3,318 patients and 459 deaths, demonstrated that an increased troponin measurement after surgery was an independent predictor of mortality (odds ratio [OR] 3.4, 95% confidence interval [CI] 2.2-5.2), but there was substantial heterogeneity (I(2) = 56%). The independent prognostic capabilities of an increased troponin value after surgery in the 10 studies that assessed intermediate-term (

Published
2011

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