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2. High water haven

Author

Scragg, Emma, Burrows, Scott, and Davidson, James

Published
2021

6. A Safeguard System for Induced Pluripotent Stem Cell-Derived Rejuvenated T Cell Therapy

Author

Ando, Miki, Nishimura, Toshinobu, Yamazaki, Satoshi, Yamaguchi, Tomoyuki, Kawana-Tachikawa, Ai, Hayama, Tomonari, Nakauchi, Yusuke, Ando, Jun, Ota, Yasunori, Takahashi, Satoshi, Nishimura, Ken, Ohtaka, Manami, Nakanishi, Mahito, Miles, John J, Burrows, Scott R, Brenner, Malcolm K, and Nakauchi, Hiromitsu

Subjects
Biochemistry and Cell Biology, Biological Sciences, Biotechnology, Regenerative Medicine, Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human, Stem Cell Research, Stem Cell Research - Induced Pluripotent Stem Cell, Stem Cell Research - Induced Pluripotent Stem Cell - Human, 5.2 Cellular and gene therapies, Development of treatments and therapeutic interventions, Animals, Apoptosis, Caspase 9, Cell Differentiation, Cells, Cultured, Genetic Therapy, Humans, Induced Pluripotent Stem Cells, Mice, SCID, Neoplasms, T-Lymphocytes, Cytotoxic, Clinical Sciences, Biochemistry and cell biology
Abstract

The discovery of induced pluripotent stem cells (iPSCs) has created promising new avenues for therapies in regenerative medicine. However, the tumorigenic potential of undifferentiated iPSCs is a major safety concern for clinical translation. To address this issue, we demonstrated the efficacy of suicide gene therapy by introducing inducible caspase-9 (iC9) into iPSCs. Activation of iC9 with a specific chemical inducer of dimerization (CID) initiates a caspase cascade that eliminates iPSCs and tumors originated from iPSCs. We introduced this iC9/CID safeguard system into a previously reported iPSC-derived, rejuvenated cytotoxic T lymphocyte (rejCTL) therapy model and confirmed that we can generate rejCTLs from iPSCs expressing high levels of iC9 without disturbing antigen-specific killing activity. iC9-expressing rejCTLs exert antitumor effects in vivo. The system efficiently and safely induces apoptosis in these rejCTLs. These results unite to suggest that the iC9/CID safeguard system is a promising tool for future iPSC-mediated approaches to clinical therapy.

Published
2015

7. 328 Preclinical analyses and proof of concept clinical study of Epstein Barr Virus (EBV) specific genetically modified T cells against EBV associated malignancies

Author

Chen, Xin-Feng, primary, Wang, Dan, additional, Huan, Jianmin, additional, Zhang, Xudong, additional, Li, Ling, additional, Zhang, XI, additional, Stripecke, Renata, additional, Burrows, Scott, additional, Han, Deping, additional, Zhang, Mingzhi, additional, and Zhang, Yi, additional

Published
2023
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11. Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry

Author

Miles, John J., Tan, Mai Ping, Dolton, Garry, Edwards, Emily S.J., Galloway, Sarah A.E., Laugel, Bruno, Clement, Mathew, Makinde, Julia, Ladell, Kristin, Matthews, Katherine K., Watkins, Thomas S., Tungatt, Katie, Wong, Yide, Lee, Han Siean, Clark, Richard J., Pentier, Johanne M., Attaf, Meriem, Lissina, Anya, Ager, Ann, Gallimore, Awen, Rizkallah, Pierre J., Gras, Stephanie, Rossjohn, Jamie, Burrows, Scott R., Cole, David K., Price, David A., and Sewell, Andrew K.

Subjects
Combinatorial chemistry -- Health aspects -- Methods, Synthetic biology -- Research, Influenza vaccines -- Research, Biomimetics -- Health aspects -- Usage, Polypeptides -- Health aspects -- Chemical properties, Pharmacological research, Health care industry
Abstract

Polypeptide vaccines effectively activate human T cells but suffer from poor biological stability, which confines both transport logistics and in vivo therapeutic activity. Synthetic biology has the potential to address these limitations through the generation of highly stable antigenic 'mimics' using subunits that do not exist in the natural world. We developed a platform based on D-amino acid combinatorial chemistry and used this platform to reverse engineer a fully artificial [CD8.sup.+] T cell agonist that mirrored the immunogenicity profile of a native epitope blueprint from influenza virus. This nonnatural peptide was highly stable in human serum and gastric acid, reflecting an intrinsic resistance to physical and enzymatic degradation. In vitro, the synthetic agonist stimulated and expanded an archetypal repertoire of polyfunctional human influenza virus-specific [CD8.sup.+] T cells. In vivo, specific responses were elicited in naive humanized mice by subcutaneous vaccination, conferring protection from subsequent lethal influenza challenge. Moreover, the synthetic agonist was immunogenic after oral administration. This proof-of-concept study highlights the power of synthetic biology to expand the horizons of vaccine design and therapeutic delivery., Introduction [CD8.sup.+] T cells recognize short peptide fragments presented by MHC class I (MHC-I) molecules on the surface of nucleated cells (1-3). These peptide-MHC-I (pMHC-I) molecular arrays are scanned by [...]

Published
2018
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13. Recycling Older Steelworkers: Post-redundancy Job-mobility Experiences of Workers from BlueScope Steel Port Kembla

Author

O'Brien, Martin and Burrows, Scott

Subjects
BHP Billiton Ltd. -- Human resource management -- International economic relations, Furnaces, Job hunting, Mineral industry -- International economic relations -- Human resource management, Displaced workers, Mining industry -- International economic relations -- Human resource management, Labor supply, Company personnel management, Business, Human resources and labor relations, Business, international
Abstract

Mass worker redundancies are a common feature associated with structural change in developed economies, particularly in the steel-manufacturing industry. Past research has highlighted the poor re-employment outcomes for older workers, with many exiting the labour force permanently and becoming dependent on social-security income. The research presented in this article uses a longitudinal and mixed-methods approach to understand the job-mobility experiences of redundant steel workers. These workers were displaced from BlueScope Steel's Port Kembla plant after the shutdown in 2011 of one of their remaining two blast furnaces. We document relatively optimistic outcomes, when compared to past research, by focusing on the post-redundancy outcomes for older workers. We highlight the roles of the mining boom and the job-search strategies and attitudes of displaced workers., 1. Introduction The current Australian steel-manufacturing industry is a minnow of its former self. It peaked in 1974-75 with 37,800 employees supplying approximately 2 per cent of the world's crude [...]

Published
2017

15. Peptide length determines the outcome of TCR/peptide-MHCI engagement

Author

Ekeruche-Makinde, Julia, Miles, John J., van den Berg, Hugo A., Skowera, Ania, Cole, David K., Dolton, Garry, Schauenburg, Andrea J.A., Tan, Mai Ping, Pentier, Johanne M., Llewellyn-Lacey, Sian, Miles, Kim M., Bulek, Anna M., Clement, Mathew, Williams, Tamsin, Trimby, Andrew, Bailey, Mick, Rizkallah, Pierre, Rossjohn, Jamie, Peakman, Mark, Price, David A., Burrows, Scott R., Sewell, Andrew K., and Wooldridge, Linda

Published
2013
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20. NOOSA JUNCTION STATION

Author

SMITH, TIM, JONES, CHRISTOPHER FREDERICK, and BURROWS, SCOTT

Published
2012

22. T cell differentiation and lineage choice are determined by the TCR

Author

Miles, John, primary, Watkins, Thomas, additional, Darko, Sam, additional, Wijaya, Kuatrinnus, additional, Cooper, Martha, additional, Ransier, Amy, additional, Waardenberg, Ashley, additional, Amante, Fiona, additional, Mccarthy, James, additional, Price, David, additional, Burrows, Scott, additional, Doolan, Denise, additional, Field, Matt, additional, and Douek, Daniel, additional

Published
2022
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23. SW1

Author

GAVENTA, SARAH, BURROWS, SCOTT, WILSHIRE, ANNA, and RAYNER, MICHAEL

Published
2011

38. Naive CD8+ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics

Author

Neller, Michelle A, Ladell, Kristin, McLaren, James E, Matthews, Katherine K, Gostick, Emma, Pentier, Johanne M, Dolton, Garry, Schauenburg, Andrea JA, Koning, Dan, CA Fontaine Costa, Ana Isabel, Watkins, Thomas S, Venturi, Vanessa, Smith, Corey, Khanna, Rajiv, Miners, Kelly, Clement, Mathew, Wooldridge, Linda, Cole, David K, van Baarle, Debbie, Sewell, Andrew K, Burrows, Scott R, Price, David A, and Miles, John J

Published
2015
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39. Antigen Ligation Triggers a Conformational Change within the Constant Domain of the αβ T Cell Receptor

Author

Beddoe, Travis, Chen, Zhenjun, Clements, Craig S., Ely, Lauren K., Bushell, Simon R., Vivian, Julian P., Kjer-Nielsen, Lars, Pang, Siew Siew, Dunstone, Michelle A., Liu, Yu Chih, Macdonald, Whitney A., Perugini, Matthew A., Wilce, Matthew C.J., Burrows, Scott R., Purcell, Anthony W., Tiganis, Tony, Bottomley, Stephen P., McCluskey, James, and Rossjohn, Jamie

Published
2009
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40. T Cell Allorecognition via Molecular Mimicry

Author

Macdonald, Whitney A., Chen, Zhenjun, Gras, Stephanie, Archbold, Julia K., Tynan, Fleur E., Clements, Craig S., Bharadwaj, Mandvi, Kjer-Nielsen, Lars, Saunders, Philippa M., Wilce, Matthew C.J., Crawford, Fran, Stadinsky, Brian, Jackson, David, Brooks, Andrew G., Purcell, Anthony W., Kappler, John W., Burrows, Scott R., Rossjohn, Jamie, and McCluskey, James

Published
2009
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43. Damien Cahill, Lindy Edwards and Frank Stilwell (eds.): Neoliberalism: Beyond the Free Market

Author

Burrows, Scott

Subjects
Neoliberalism: Beyond the Free Market (Nonfiction work) -- Cahill, Damien -- Edwards, Lindy -- Stilwell, Frank -- Book reviews, Books -- Book reviews, Economics
Abstract

Damien Cahill, Lindy Edwards and Frank Stilwell (eds.) Neoliberalism: Beyond the Free Market, Edward Elgar Publishing: Cheltenham, 2012; 288 pp: 978-1781002346, 67.50 [pounds sterling] (hbk) Neoliberalism: Beyond the Free Market [...]

Published
2013
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44. Small UAV Automatic Ground Collision Avoidance System Design Considerations and Flight Test Results

Author

Sorokowski, Paul, Skoog, Mark, Burrows, Scott, and Thomas, SaraKatie

Subjects
Aircraft Design, Testing And Performance
Abstract

The National Aeronautics and Space Administration (NASA) Armstrong Flight Research Center Small Unmanned Aerial Vehicle (SUAV) Automatic Ground Collision Avoidance System (Auto GCAS) project demonstrated several important collision avoidance technologies. First, the SUAV Auto GCAS design included capabilities to take advantage of terrain avoidance maneuvers flying turns to either side as well as straight over terrain. Second, the design also included innovative digital elevation model (DEM) scanning methods. The combination of multi-trajectory options and new scanning methods demonstrated the ability to reduce the nuisance potential of the SUAV while maintaining robust terrain avoidance. Third, the Auto GCAS algorithms were hosted on the processor inside a smartphone, providing a lightweight hardware configuration for use in either the ground control station or on board the test aircraft. Finally, compression of DEM data for the entire Earth and successful hosting of that data on the smartphone was demonstrated. The SUAV Auto GCAS project demonstrated that together these methods and technologies have the potential to dramatically reduce the number of controlled flight into terrain mishaps across a wide range of aviation platforms with similar capabilities including UAVs, general aviation aircraft, helicopters, and model aircraft.

Published
2015

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