1. Mutation in bovine beta-carotene oxygenase 2 affects milk color.
- Author
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Berry SD, Davis SR, Beattie EM, Thomas NL, Burrett AK, Ward HE, Stanfield AM, Biswas M, Ankersmit-Udy AE, Oxley PE, Barnett JL, Pearson JF, van der Does Y, Macgibbon AH, Spelman RJ, Lehnert K, and Snell RG
- Subjects
- Amino Acid Sequence, Animals, Base Sequence, Cattle, Chromosomes, Mammalian genetics, Color, Crosses, Genetic, DNA Mutational Analysis, Female, Genotype, Male, Milk chemistry, Oxygenases metabolism, Polymorphism, Single Nucleotide, Quantitative Trait Loci genetics, beta Carotene blood, beta Carotene metabolism, Milk metabolism, Mutation, Oxygenases genetics
- Abstract
beta-Carotene biochemistry is a fundamental process in mammalian biology. Aberrations either through malnutrition or potentially through genetic variation may lead to vitamin A deficiency, which is a substantial public health burden. In addition, understanding the genetic regulation of this process may enable bovine improvement. While many bovine QTL have been reported, few of the causative genes and mutations have been identified. We discovered a QTL for milk beta-carotene and subsequently identified a premature stop codon in bovine beta-carotene oxygenase 2 (BCO2), which also affects serum beta-carotene content. The BCO2 enzyme is thereby identified as a key regulator of beta-carotene metabolism.
- Published
- 2009
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