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Testbeds have become integral to advancing the transfer of knowledge and capabilities from research to operational weather forecasting in many parts of the world. The first high-impact weather testbed in tropical Africa was recently carried out through the African SWIFT program, with participation from researchers and forecasters from Senegal, Ghana, Nigeria, Kenya, the United Kingdom, and international and pan-African organizations. The testbed aims were to trial new forecasting and nowcasting products with operational forecasters, to inform future research, and to act as a template for future testbeds in the tropics. The African SWIFT testbed integrated users and researchers throughout the process to facilitate development of impact-based forecasting methods and new research ideas driven both by operations and user input. The new products are primarily satellite-based nowcasting systems and ensemble forecasts at global and regional convection-permitting scales. Neither of these was used operationally in the participating African countries prior to the testbed. The testbed received constructive, positive feedback via intense user interaction including fishery, agriculture, aviation, and electricity sectors. After the testbed, a final set of recommended standard operating procedures for satellite-based nowcasting in tropical Africa have been produced. The testbed brought the attention of funding agencies and organizational directors to the immediate benefit of improved forecasts. Delivering the testbed strengthened the partnership between each country’s participating university and weather forecasting agency and internationally, which is key to ensuring the longevity of the testbed outcomes.

Background: The unique immunomodulatory capacity of helminth parasites has been investigated as a novel strategy in the prevention of allograft rejection after transplantation. This review was conducted to fully evaluate the specific effects of helminth therapy on allograft survival reported in published studies of animal models of allogeneic transplantation. Method: Following PRISMA protocol guidelines, a literature search was conducted using PubMed, MEDLINE via OvidSP, along with additional manual searches of selected reference lists. Publications describing helminth intervention within allograft transplantation models were screened for relevance to eligibility criteria. Primary and secondary outcomes were extracted using standardized data collection tables. The SYRCLE risk of bias assessment tool was used for quality assessment. Due to heterogeneity of study designs, meta-analysis could not be performed; rather outcomes are presented as a narrative synthesis with concept mapping. This review was registered in PROSPERO with ID: CRD42018097175. Results: The literature search generated 1,443 publications, which after screening for relevance to the eligibility criteria yielded 15 publications for qualitative analysis. All 15 publications reported improvement to allograft survival as a result of helminth therapy. This prolonged allograft survival was not significantly different when helminth-derived products were used compared to live infection. However, the extent of positive impact on allograft survival was noted to be dependent on study design factors, such as the chronicity of the live helminth infection, allograft type and the species/genus of helminth selected. Conclusion: Both live and product-based helminth therapy have potential applications as novel immune regulators or adjuncts for the prevention of allograft rejection. However, there were differences in efficacy between different worms and preparations of worm-derived products. Therefore, further studies are required to determine the most appropriate worm for a specific allograft, to elucidate the optimal dose and route of administration, and to better understand the modulation of immune responses that can mediate tolerance.