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196 results on '"Burmester, James K."'

3. Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study

Author

Perera, Minoli A, Cavallari, Larisa H, Limdi, Nita A, Gamazon, Eric R, Konkashbaev, Anuar, Daneshjou, Roxana, Pluzhnikov, Anna, Crawford, Dana C, Wang, Jelai, Liu, Nianjun, Tatonetti, Nicholas, Bourgeois, Stephane, Takahashi, Harumi, Bradford, Yukiko, Burkley, Benjamin M, Desnick, Robert J, Halperin, Jonathan L, Khalifa, Sherief I, Langaee, Taimour Y, Lubitz, Steven A, Nutescu, Edith A, Oetjens, Matthew, Shahin, Mohamed H, Patel, Shitalben R, Sagreiya, Hersh, Tector, Matthew, Weck, Karen E, Rieder, Mark J, Scott, Stuart A, Wu, Alan HB, Burmester, James K, Wadelius, Mia, Deloukas, Panos, Wagner, Michael J, Mushiroda, Taisei, Kubo, Michiaki, Roden, Dan M, Cox, Nancy J, Altman, Russ B, Klein, Teri E, Nakamura, Yusuke, and Johnson, Julie A

Published
2013
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5. Analysis of Candidate Genes for Prostate Cancer

Author

Burmester, James K., Suarez, Brian K., Lin, Jennifer H., Jin, Carol H., Miller, Raymond D., Zhang, Kai-Qi, Salzman, Sherry A., Reding, Douglas J., and Catalona, William J.

Published
2004

6. Identification of Stevens–Johnson syndrome and toxic epidermal necrolysis in electronic health record databases†

Author

Davis, Robert L., Gallagher, Mia A., Asgari, Maryam M., Eide, Melody J., Margolis, David J., Macy, Eric, Burmester, James K., Selvam, Nandini, Boscarino, Joseph A., Cromwell, Lee F., Feigelson, Heather S., Kuntz, Jennifer L., Pawloski, Pamala A., Penfold, Robert B., Raebel, Marsha A., Sridhar, Gayathri, Wu, Ann, La Grenade, Lois A., Pacanowski, Michael A., and Pinheiro, Simone P.

Published
2015
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12. CYP4F2 genetic variant alters required warfarin dose

Author

Caldwell, Michael D., Awad, Tarif, Johnson, Julie A., Gage, Brian F., Falkowski, Mat, Gardina, Paul, Hubbard, Jason, Turpaz, Yaron, Langaee, Taimour Y., Eby, Charles, King, Cristi R., Brower, Amy, Schmelzer, John R., Glurich, Ingrid, Vidaillet, Humberto J., Yale, Steven H., Qi Zhang, Kai, Berg, Richard L., and Burmester, James K.

Published
2008
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20. Intraocular pressure response to topical [beta]-blockers associated with an ADRB2 single-nucleotide polymorphism

Author

McCarty, Catherine A., Burmester, James K., Mukesh, Bickol N., Patchett, Richard B., and Wilke, Russell A.

Subjects
Glaucoma -- Care and treatment, Glaucoma -- Genetic aspects, Glaucoma -- Research, Adrenergic beta blockers -- Dosage and administration, Adrenergic beta blockers -- Genetic aspects, Pharmacokinetics -- Research, Cytochrome P-450 -- Dosage and administration, Cytochrome P-450 -- Genetic aspects, Intraocular pressure -- Genetic aspects, Intraocular pressure -- Physiological aspects, Intraocular pressure -- Research, Single nucleotide polymorphisms -- Analysis, Health
Published
2008

21. DLL3 as a candidate gene for vertebral malformations

Author

Giampietro, Philip F., Raggio, Cathleen L., Reynolds, Cory, Ghebranious, Nader, Burmester, James K., Glurich, Ingrid, Rasmussen, Kristen, McPherson, Elizabeth, Pauli, Richard M., Shukla, Sanjay K., Merchant, Sajid, Jacobsen, Stig F., Faciszewski, Thomas, and Blank, Robert D.

Published
2006
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24. Characterization of mutated transforming growth factor-beta(s) which possess unique biological properties

Author

Qian, Su Wen, Burmester, James K., Sun, Peter D., Huang, Alison, Ohlsen, Dennis J., Suardet, Laurent, Flanders, Kathleen C., Davies, David, Roberts, Anita B., and Sporn, Michael B.

Subjects
Transforming growth factors -- Research, Binding sites (Biochemistry) -- Research, Biological sciences, Chemistry
Abstract

Experimental synthesis and analysis of two mutant transforming growth factor-beta (TGF-beta) molecules, TGF-beta1 (Delta69-73) and TGF-beta1 (71 Trp), reveal that the two mutant molecules have distinct biological properties and modifications in the amino acid 71 region influence the receptor binding activity of TGF-beta. TGF-beta1 (Delta69-73) is a less potent suppressor of colorectal cancer cells than TGF-beta1 (71 Trp) and less potent regulator of carcino embryonic antigen mRNA than TGF-beta1 (71 Trp). TGF-beta1 (71 Trp) binds strongly to Mv1Lu and LS1034 cell receptors while both exhibit similar bindings properties to type II receptor.

Published
1994

25. Characterization of distinct functional domains of transforming growth factor beta

Author

Burmester, James K., Su Wen Qian, Roberts, Anita B., Huang, Alison, Amatayakul-Chantler, Supavadee, Suardet, Laurent, Odartchenko, Nicolas, Madri, Joseph A., and Sporn, Michael B.

Subjects
Transforming growth factors -- Research, Circular DNA -- Evaluation, Amino acid sequence -- Analysis, Science and technology
Abstract

The varying potencies of transforming growth factor (TGF) beta2 and TGF-beta1 on the fetal bovine heart endothelial cell development are due to aa 45 and 47 amino acids. TGF-beta1 and TGF-beta2 are the functional domains of TGF-beta, the former being sequestered by alpha2-macroglobulin. The activity of TGF-beta1 with aa 40-82 can be specified by amino acids external to the aa 40-82 region.

Published
1993

26. Identification of a structural domain that distinguishes the actions of the type 1 and 2 isoforms of transforming growth factor beta on endothelial cells

Author

Su Wen Qian, Burmester, James K., Merwin, June R., Madri, Joseph A., Sporn, Michael B., and Roberts, Anita B.

Subjects
Growth factor receptors -- Research, Transforming growth factors -- Genetic aspects, Science and technology
Abstract

Amino acids responsible for the enhanced activity of transforming growth factor beta1 (TGF) and TGF beta2 on the growth and migration of endothelial cells were mapped using a chimeric TGF-beta molecule. Results show that the sequence between amino acids 40 and 82 of the mature TGF-beta molecule specifies TGF-beta1 potency on both the growth and migration of endothelial cells. The use of chimeric molecules is seen as a practical approach to investigating the structure and function relationships in closely related proteins.

Published
1992

31. Lack of Association Between Polymorphisms in the Prostaglandin F2α Receptor (PTGFR) and Solute Carrier Organic Anion Transporter Family 2A1 (SLCO2A1) Genes and Intraocular Pressure Response to Prostaglandin Analogs

Author

McCarty, Catherine A., Berg, Richard, Patchett, Richard, Wilke, Russell A., and Burmester, James K.

Subjects
Genotype, Pharmacogenetics, Prostaglandins F, Synthetic, Receptors, Prostaglandin, Humans, Latanoprost, Organic Anion Transporters, Ocular Hypertension, Polymorphism, Single Nucleotide, Article, Antihypertensive Agents, Glaucoma, Open-Angle, Intraocular Pressure
Abstract

To evaluate the association between variants in the prostaglandin F(α) receptor (PTGFR) and solute carrier organic anion transporter family 2A1 (SLCO2A1) genes and intraocular pressure (IOP) response to prostaglandin analogs.The medical records of subjects with previously diagnosed open angle glaucoma or ocular hypertension were searched for intraocular pressure measurements before and after prescriptions of prostaglandin analogs. Stored DNA samples were genotyped for the following SNPs: rs3753380 (promoter region) and rs3766355 (intronic region) of the prostaglandin F(2α) receptor gene, and rs34550074 (Ala396Thr) of SLCO2A1. The mean change in IOP by genotype was measured.Prostaglandin analogs were prescribed to 267 subjects; 242 (204 right eyes, 205 left eyes) met the inclusion/exclusion criteria for the current study. There was no significant association between genotype and IOP response to prostaglandin analogs (p = 0.48, p = 0.54, p = 0.90).In summary, we found no indication for an association between SNPs in the prostaglandin F(2α) receptor gene or SLCO2A1 and IOP response to prostaglandin analogs in a population of European descent.

Published
2011

32. The Differential Diagnosis of Pulmonary Blastomycosis Using Case Vignettes: A Wisconsin Network for Health Research (WiNHR) Study

Author

Baumgardner, Dennis J., Temte, Jonathan L., Gutowski, Erin, Agger, William A., Bailey, Howard, Burmester, James K., and Banerjee, Indrani

Subjects
Adult, Diagnosis, Differential, Male, Wisconsin, Lung Diseases, Fungal, Incidence, Humans, Female, Middle Aged, Article, Blastomycosis
Abstract

Pulmonary blastomycosis is an uncommon but serious fungal infection endemic in Wisconsin. Clinician awareness of the protean presentations of this disease may reduce diagnostic delay. This study addressed the diagnostic accuracy of physicians responding to case vignettes of pulmonary blastomycosis and the primary care differential diagnosis of this disease.Eight pulmonary blastomycosis cases were developed from case files. From these, 2 vignettes were randomly selected and mailed to primary care physicians in the Wisconsin Network for Health Research. Respondents were asked to list the 3 most likely diagnoses for each case.Respondents listed Blastomycosis as the most likely diagnosis for 37/227 (16%) case vignettes, and 1 of the 3 most likely diagnoses for 43/227 (19%). When vignettes included patient activity in counties with an annual incidence rate of blastomycosis greater than 2/100,000, compared to counties with lower incidence rates, diagnosis was more accurate (28/61 [46%] vs 15/166 [9%]; P0.001). Physicians with practice locations in counties with annual blastomycosis incidence rates2/100,000 listed blastomycosis more commonly than physicians from other counties (16/36 [44%] vs 27/177 [15%]; P0.001). This difference in accurate diagnosis remained significant in a multivariate model of practice demographics. Based on responses to the vignettes, pneumonia, cancer, non-infectious pulmonary disease, and tuberculosis emerged as the most-frequently noted diagnosis in the differential diagnosis of blastomycosis.Blastomycosis was not listed as 1of 3 primary diagnoses in a majority of cases when Wisconsin primary care physicians considered case vignettes of actual pulmonary blastomycosis cases. Diagnosis was more accurate if the patient vignette listed exposure to a higher incidence county, or if the physician practiced in a higher incidence county. In Wisconsin, failure to include blastomycosis in the differential diagnoses of illnesses associated with a wide variety of pulmonary symptoms suspected to represent infectious or non-infectious pulmonary, cardiac, or neoplastic disease, regardless of geographic exposure, could result in excess morbidity or mortality.

Published
2011

33. Genome-wide association study of warfarin maintenance dose in a Brazilian sample

Author

Parra, Esteban J., Botton, Mariana R., Perini, Jamila A., Krithika, S., Bourgeois, Stephane, Johnson, Todd A., Tsunoda, Tatsuhiko, Pirmohamed, Munir, Wadelius, Mia, Limdi, Nita A., Cavallari, Larisa H., Burmester, James K., Rettie, Allan E., Klein, Teri E., Johnson, Julie A., Hutz, Mara H., Suarez-Kurtz, Guilherme, Parra, Esteban J., Botton, Mariana R., Perini, Jamila A., Krithika, S., Bourgeois, Stephane, Johnson, Todd A., Tsunoda, Tatsuhiko, Pirmohamed, Munir, Wadelius, Mia, Limdi, Nita A., Cavallari, Larisa H., Burmester, James K., Rettie, Allan E., Klein, Teri E., Johnson, Julie A., Hutz, Mara H., and Suarez-Kurtz, Guilherme

Abstract

Aim: Extreme discordant phenotype and genome-wide association (GWA) approaches were combined to explore the role of genetic variants on warfarin dose requirement in Brazilians. Methods: Patients receiving low (<= 20 mg/week; n = 180) or high stable warfarin doses (>= 42.5 mg/week; n = 187) were genotyped with Affymetrix Axiom (R) Biobank arrays. Imputation was carried out using data from the combined 1000 Genomes project. Results: Genome-wide signals (p <= 5 x 10(-8)) were identified in the well-known VKORC1 (lead SNP, rs749671; OR: 20.4; p = 1.08 x 10(-33)) and CYP2C9 (lead SNP, rs9332238, OR: 6.8 and p = 4.4 x 10(-13)) regions. The rs9332238 polymorphism is in virtually perfect LD with CYP2C9*2 (rs1799853) and CYP2C9*3 (rs1057910). No other genome-wide significant regions were identified in the study. Conclusion: We confirmed the important role of VKORC1 and CYP2C9 polymorphisms in warfarin dose.

Published
2015
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34. Genome-wide association study of warfarin maintenance dose in a Brazilian sample

Author

Parra, Esteban J, primary, Botton, Mariana R, additional, Perini, Jamila A, additional, Krithika, S, additional, Bourgeois, Stephane, additional, Johnson, Todd A, additional, Tsunoda, Tatsuhiko, additional, Pirmohamed, Munir, additional, Wadelius, Mia, additional, Limdi, Nita A, additional, Cavallari, Larisa H, additional, Burmester, James K, additional, Rettie, Allan E, additional, Klein, Teri E, additional, Johnson, Julie A, additional, Hutz, Mara H, additional, and Suarez-Kurtz, Guilherme, additional

Published
2015
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36. Genetic variants associated with warfarin dose in African-American individuals : a genome-wide association study

Author

Perera, Minoli A., Cavallari, Larisa H., Limdi, Nita A., Gamazon, Eric R., Konkashbaev, Anuar, Daneshjou, Roxana, Pluzhnikov, Anna, Crawford, Dana C., Wang, Jelai, Liu, Nianjun, Tatonetti, Nicholas, Bourgeois, Stephane, Takahashi, Harumi, Bradford, Yukiko, Burkley, Benjamin M., Desnick, Robert J., Halperin, Jonathan L., Khalifa, Sherief I., Langaee, Taimour Y., Lubitz, Steven A., Nutescu, Edith A., Oetjens, Matthew, Shahin, Mohamed H., Patel, Shitalben R., Sagreiya, Hersh, Tector, Matthew, Weck, Karen E., Rieder, Mark J., Scott, Stuart A., Wu, Alan H. B., Burmester, James K., Wadelius, Mia, Deloukas, Panos, Wagner, Michael J., Mushiroda, Taisei, Kubo, Michiaki, Roden, Dan M., Cox, Nancy J., Altman, Russ B., Klein, Teri E., Nakamura, Yusuke, Johnson, Julie A., Perera, Minoli A., Cavallari, Larisa H., Limdi, Nita A., Gamazon, Eric R., Konkashbaev, Anuar, Daneshjou, Roxana, Pluzhnikov, Anna, Crawford, Dana C., Wang, Jelai, Liu, Nianjun, Tatonetti, Nicholas, Bourgeois, Stephane, Takahashi, Harumi, Bradford, Yukiko, Burkley, Benjamin M., Desnick, Robert J., Halperin, Jonathan L., Khalifa, Sherief I., Langaee, Taimour Y., Lubitz, Steven A., Nutescu, Edith A., Oetjens, Matthew, Shahin, Mohamed H., Patel, Shitalben R., Sagreiya, Hersh, Tector, Matthew, Weck, Karen E., Rieder, Mark J., Scott, Stuart A., Wu, Alan H. B., Burmester, James K., Wadelius, Mia, Deloukas, Panos, Wagner, Michael J., Mushiroda, Taisei, Kubo, Michiaki, Roden, Dan M., Cox, Nancy J., Altman, Russ B., Klein, Teri E., Nakamura, Yusuke, and Johnson, Julie A.

Abstract

Background VKORC1 and CYP2C9 are important contributors to warfarin dose variability, but explain less variability for individuals of African descent than for those of European or Asian descent. We aimed to identify additional variants contributing to warfarin dose requirements in African Americans. Methods We did a genome-wide association study of discovery and replication cohorts. Samples from African-American adults (aged >= 18 years) who were taking a stable maintenance dose of warfarin were obtained at International Warfarin Pharmacogenetics Consortium (IWPC) sites and the University of Alabama at Birmingham (Birmingham, AL, USA). Patients enrolled at IWPC sites but who were not used for discovery made up the independent replication cohort. All participants were genotyped. We did a stepwise conditional analysis, conditioning first for VKORC1 -1639G -> A, followed by the composite genotype of CYP2C9*2 and CYP2C9*3. We prespecified a genome-wide significance threshold of p<5x10(-8) in the discovery cohort and p<0.0038 in the replication cohort. Findings The discovery cohort contained 533 participants and the replication cohort 432 participants. After the prespecified conditioning in the discovery cohort, we identified an association between a novel single nucleotide polymorphism in the CYP2C cluster on chromosome 10 (rs12777823) and warfarin dose requirement that reached genome-wide significance (p=1.51x10(-8)). This association was confirmed in the replication cohort (p=5.04x10(-5)); analysis of the two cohorts together produced a p value of 4.5x10(-12). Individuals heterozygous for the rs12777823 A allele need a dose reduction of 6.92 mg/week and those homozygous 9.34 mg/week. Regression analysis showed that the inclusion of rs12777823 significantly improves warfarin dose variability explained by the IWPC dosing algorithm (21% relative improvement). Interpretation A novel CYP2C single nucleotide polymorphism exerts a clinically relevant effect on wa

Published
2013
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37. Methodologic aspects of glaucoma pharmacogenomic studies

Author

Leffler, Christopher T., McCarty, Catherine A., Burmester, James K., Mukesh, Bickol N., Patchett, Richard B., and Wilke, Russell A.

Subjects
Adrenergic beta blockers -- Dosage and administration, Methodology -- Influence, Clinical trials -- Methods, Glaucoma -- Drug therapy, Glaucoma -- Patient outcomes, Pharmacogenetics -- Research, Health
Published
2009

39. Pathway analysis of genome-wide data improves warfarin dose prediction

Author

Daneshjou, Roxana, primary, Tatonetti, Nicholas P, additional, Karczewski, Konrad J, additional, Sagreiya, Hersh, additional, Bourgeois, Stephane, additional, Drozda, Katarzyna, additional, Burmester, James K, additional, Tsunoda, Tatsuhiko, additional, Nakamura, Yusuke, additional, Kubo, Michiaki, additional, Tector, Matthew, additional, Limdi, Nita A, additional, Cavallari, Larisa H, additional, Perera, Minoli, additional, Johnson, Julie A, additional, Klein, Teri E, additional, and Altman, Russ B, additional

Published
2013
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43. WARFARIN DOSING ALGORITHM REFINEMENTS AFTER 7-9 DAYS OF THERAPY BASED ON PHARMACOGENETIC, PHARMACOKINETIC, CLINICAL, AND LABORATORY DATA

Author

Horne, Benjamin D., primary, Lenzini, Petra A., additional, Wadelius, Mia, additional, Jorgensen, Andrea L., additional, Kimmel, Stephen E., additional, Eriksson, Niclas, additional, Anderson, Jeffrey L., additional, Pirmohamed, Munir, additional, Limdi, Nita A., additional, Burmester, James K., additional, Kurnik, Daniel, additional, Stein, Charles M., additional, Caldwell, Michael D., additional, Eby, Charles S., additional, Rane, Anders, additional, Lindh, John D., additional, Shin, Jae-Gook, additional, Kim, Ho-Sook, additional, Angchaisuksiri, Pantep, additional, Chen, Jinbo, additional, Carlquist, John F., additional, Grice, Gloria R., additional, Kronquist, Kathryn E., additional, and Gage, Brian F., additional

Published
2010
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46. A Missense T(Brachyury) Mutation Contributes to Vertebral Malformations

Author

Ghebranious, Nader, primary, Blank, Robert D, additional, Raggio, Cathleen L, additional, Staubli, Justin, additional, McPherson, Elizabeth, additional, Ivacic, Lynn, additional, Rasmussen, Kristen, additional, Jacobsen, F Stig, additional, Faciszewski, Thomas, additional, Burmester, James K, additional, Pauli, Richard M, additional, Boachie-Adjei, Oheneba, additional, Glurich, Ingrid, additional, and Giampietro, Philip F, additional

Published
2008
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