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Your search keyword '"Burling, K.A. (Keith)"' showing total 2 results
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2 results on '"Burling, K.A. (Keith)"'

1. Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: Results of genome-wide association analyses including 4659 European individuals

Author

Heid, I.M. (Iris), Henneman, P. (Peter), Hicks, A.A. (Andrew), Coassin, S. (Stefan), Winkler, T.W. (Thomas), Aulchenko, Y.S. (Yurii), Fuchsberger, C. (Christian), Song, K. (Kijoung), Hivert, M.-F. (Marie-France), Waterworth, D. (Dawn), Timpson, N.J. (Nicholas), Richards, J.B. (Brent), Perry, J.R.B. (John), Tanaka, T. (Toshiko), Amin, N. (Najaf), Kollerits, B. (Barbara), Pichler, I. (Irene), Oostra, B.A. (Ben), Thorand, B. (Barbara), Frants, R.R. (Rune), Illig, T. (Thomas), Dupuis, J. (Josée), Glaser, B. (Beate), Spector, T.D. (Timothy), Guralnik, J.M. (Jack), Egan, J.M. (Josephine), Florez, J.C. (Jose), Evans, D.M. (David), Soranzo, N. (Nicole), Bandinelli, S. (Stefania), Carlson, O.D. (Olga), Frayling, T.M. (Timothy), Burling, K.A. (Keith), Smith, A.V. (Davey), Mooser, V. (Vincent), Ferrucci, L. (Luigi), Meigs, J.B. (James), Vollenweider, P. (Peter), Dijk, K.W.v., Pramstaller, P.P. (Peter Paul), Kronenberg, F. (Florian), Tikka-Kleemola, P. (Päivi), Heid, I.M. (Iris), Henneman, P. (Peter), Hicks, A.A. (Andrew), Coassin, S. (Stefan), Winkler, T.W. (Thomas), Aulchenko, Y.S. (Yurii), Fuchsberger, C. (Christian), Song, K. (Kijoung), Hivert, M.-F. (Marie-France), Waterworth, D. (Dawn), Timpson, N.J. (Nicholas), Richards, J.B. (Brent), Perry, J.R.B. (John), Tanaka, T. (Toshiko), Amin, N. (Najaf), Kollerits, B. (Barbara), Pichler, I. (Irene), Oostra, B.A. (Ben), Thorand, B. (Barbara), Frants, R.R. (Rune), Illig, T. (Thomas), Dupuis, J. (Josée), Glaser, B. (Beate), Spector, T.D. (Timothy), Guralnik, J.M. (Jack), Egan, J.M. (Josephine), Florez, J.C. (Jose), Evans, D.M. (David), Soranzo, N. (Nicole), Bandinelli, S. (Stefania), Carlson, O.D. (Olga), Frayling, T.M. (Timothy), Burling, K.A. (Keith), Smith, A.V. (Davey), Mooser, V. (Vincent), Ferrucci, L. (Luigi), Meigs, J.B. (James), Vollenweider, P. (Peter), Dijk, K.W.v., Pramstaller, P.P. (Peter Paul), Kronenberg, F. (Florian), and Tikka-Kleemola, P. (Päivi)

Abstract

Objective: Plasma adiponectin is strongly associated with various components of metabolic syndrome, type 2 diabetes and cardiovascular outcomes. Concentrations are highly heritable and differ between men and women. We therefore aimed to investigate the genetics of plasma adiponectin in men and women. Methods: We combined genome-wide association scans of three population-based studies including 4659 persons. For the replication stage in 13795 subjects, we selected the 20 top signals of the combined analysis, as well as the 10 top signals with p-values less than 1.0 × 10-4for each the men- and the women-specific analyses. We further selected 73 SNPs that were consistently associated with metabolic syndrome parameters in previous genome-wide association studies to check for their association wit

Published
2010
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2. A genome-wide association study reveals variants in ARL15 that influence adiponectin levels

Author

Richards, J.B. (Brent), Waterworth, D. (Dawn), O'Rahilly, S. (Stephen), Hivert, M.-F. (Marie-France), Loos, R.J.F. (Ruth), Perry, J.R.B. (John), Tanaka, T. (Toshiko), Timpson, N.J. (Nicholas), Semple, R.K. (Robert), Soranzo, N. (Nicole), Song, K. (Kijoung), Rocha, N. (Nuno), Grundberg, E. (Elin), Dupuis, J. (Josée), Florez, J.C. (Jose), Langenberg, C. (Claudia), Prokopenko, I. (Inga), Saxena, R. (Richa), Sladek, R. (Rob), Aulchenko, Y.S. (Yurii), Evans, D.M. (David), Waeber, G. (Gérard), Burnett, M.S., Sattar, N. (Naveed), Devaney, J. (Joseph), Willenborg, C. (Christina), Hingorani, A. (Aroon), Witteman, J.C.M. (Jacqueline), Vollenweider, P. (Peter), Glaser, B. (Beate), Hengstenberg, C. (Christian), Ferrucci, L. (Luigi), Melzer, D. (David), Stark, K. (Klaus), Deanfield, J. (John), Winogradow, J. (Janina), Grassl, M. (Martina), Hall, A.S. (Alistair), Egan, J.M. (Josephine), Thompson, J.R. (John), Ricketts, S.L. (Sally), König, I.R. (Inke), Reinhard, W. (Wibke), Grundy, S.M. (Scott), Wichmann, H.E. (Heinz Erich), Barter, P. (Phil), Mahley, R. (Robert), Kesaniemi, Y.A. (Antero), Rader, D.J. (Daniel), Reilly, M.P. (Muredach), Epstein, S.E. (Stephen), Stewart, A.F.R. (Alexandre), Tikka-Kleemola, P. (Päivi), Schunkert, H. (Heribert), Burling, K.A. (Keith), Erdmann, J. (Jeanette), Deloukas, P. (Panagiotis), Pastinen, T. (Tomi), Samani, N.J. (Nilesh), McPherson, R. (Ruth), Smith, A.V. (Davey), Frayling, T.M. (Timothy), Wareham, N.J. (Nick), Meigs, J.B. (James), Mooser, V. (Vincent), Spector, T.D. (Timothy), Richards, J.B. (Brent), Waterworth, D. (Dawn), O'Rahilly, S. (Stephen), Hivert, M.-F. (Marie-France), Loos, R.J.F. (Ruth), Perry, J.R.B. (John), Tanaka, T. (Toshiko), Timpson, N.J. (Nicholas), Semple, R.K. (Robert), Soranzo, N. (Nicole), Song, K. (Kijoung), Rocha, N. (Nuno), Grundberg, E. (Elin), Dupuis, J. (Josée), Florez, J.C. (Jose), Langenberg, C. (Claudia), Prokopenko, I. (Inga), Saxena, R. (Richa), Sladek, R. (Rob), Aulchenko, Y.S. (Yurii), Evans, D.M. (David), Waeber, G. (Gérard), Burnett, M.S., Sattar, N. (Naveed), Devaney, J. (Joseph), Willenborg, C. (Christina), Hingorani, A. (Aroon), Witteman, J.C.M. (Jacqueline), Vollenweider, P. (Peter), Glaser, B. (Beate), Hengstenberg, C. (Christian), Ferrucci, L. (Luigi), Melzer, D. (David), Stark, K. (Klaus), Deanfield, J. (John), Winogradow, J. (Janina), Grassl, M. (Martina), Hall, A.S. (Alistair), Egan, J.M. (Josephine), Thompson, J.R. (John), Ricketts, S.L. (Sally), König, I.R. (Inke), Reinhard, W. (Wibke), Grundy, S.M. (Scott), Wichmann, H.E. (Heinz Erich), Barter, P. (Phil), Mahley, R. (Robert), Kesaniemi, Y.A. (Antero), Rader, D.J. (Daniel), Reilly, M.P. (Muredach), Epstein, S.E. (Stephen), Stewart, A.F.R. (Alexandre), Tikka-Kleemola, P. (Päivi), Schunkert, H. (Heribert), Burling, K.A. (Keith), Erdmann, J. (Jeanette), Deloukas, P. (Panagiotis), Pastinen, T. (Tomi), Samani, N.J. (Nilesh), McPherson, R. (Ruth), Smith, A.V. (Davey), Frayling, T.M. (Timothy), Wareham, N.J. (Nick), Meigs, J.B. (James), Mooser, V. (Vincent), and Spector, T.D. (Timothy)

Abstract

The adipocyte-derived protein adiponectin is highly heritable and inversely associated with risk of type 2 diabetes mellitus (T2D) and coronary heart disease (CHD). We meta-analyzed 3 genome-wide association studies for circulating adiponectin levels (n = 8,531) and sought validation of the lead single nucleotide polymorphisms (SNPs) in 5 additional cohorts (n = 6,202). Five SNPs were genome-wide significant in their relationship with adiponectin (P≤5×10-8). We then tested whether these 5 SNPs were associated with risk of T2D and CHD using a Bonferroni-corrected threshold of P≤0.011 to declare statistical significance for these disease associations. SNPs at the adiponectin-encoding ADIPOQ locus demonstrated the strongest associations with adiponectin levels (P-combined = 9.2×10-19for lead SNP, rs266717, n = 14,733). A novel variant in the ARL15 (ADP-ribosylation factor-like 15) gene was associated with lower circulating levels of adiponectin (rs4311394-G, P-combined = 2.9×10-8, n = 14,733). This same risk allele at ARL15 was also associated with a higher risk of CHD (odds ratio [OR] = 1.12, P = 8.5×10-6, n = 22,421) more nominally, an increased risk of T2D (OR = 1.11, P = 3.2×10-3, n = 10,128), and several metabolic traits. Expression studies in humans indicated that ARL15 is well-expressed in skeletal

Published
2009
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