315 results on '"Burkitt Lymphoma diagnostic imaging"'
Search Results
2. 2-[ 18 ]F FDG PET/CT dissemination features in adult burkitt lymphoma Are predictive of outcome.
- Author
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Albano D, Calabrò A, Talin A, Dondi F, Pagani C, Tucci A, Treglia G, and Bertagna F
- Subjects
- Humans, Male, Female, Adult, Middle Aged, Retrospective Studies, Aged, Prognosis, Young Adult, Aged, 80 and over, Adolescent, Radiopharmaceuticals, Follow-Up Studies, Burkitt Lymphoma diagnostic imaging, Positron Emission Tomography Computed Tomography, Fluorodeoxyglucose F18
- Abstract
This retrospective study investigated the prognostic role of disease dissemination features (Dmax and Dmax
bsa ) measured by 2-[18 F]FDG PET/CT in newly diagnosed Burkitt Lymphoma (BL) patients, comparing their performance with other metabolic parameters. We included 78 patients diagnosed with BL between 2010 and 2022 with an available baseline PET, interim PET/CT (iPET) and end of treatment PET/CT (eotPET) and with a minimum of two 2-[18 F]FDG avid lesions present at the baseline scan. Dmax was calculated from the three-dimensional coordinates of the baseline metabolic tumor volume (MTV) by using LIFEx software; Dmaxbsa was calculated as Dmax normalized for body surface area according to the Du Bois method. We evaluated their effect on metabolic treatment response evaluated by PET, on progression free survival (PFS) and on overall survival (OS). Dmaxbsa was significantly associated with tumor stage, bulky and extranodal disease, MTV and TLG. At a median follow-up of 49 months, the median PFS and OS were 45 and 48 months. Dmax and Dmaxbsa were significantly higher in not complete metabolic response than complete metabolic response group at iPET and eotPET.As far as PFS, parameters including iPET/CT, eotPET/CT outcomes, MTV and TLG showed to be independent prognostic factors while Dmax and Dmaxbsa were not significantly associated with the outcome. Dissemination features, together with eotPET/CT results, MTV and TLG, demonstrated to be significantly correlated with OS. In conclusion, in this study we demonstrated that dissemination features derived by 2[18 F]-FDG PET/CT were significantly correlated with response to treatment and long-term outcome, independently from other PET features., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)- Published
- 2024
- Full Text
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3. Refractory Burkitt Lymphoma With False-positive and False-negative Mass Detected on Positron Emission Tomography-computed Tomography After Chemotherapy.
- Author
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Shima H, Takaki T, Ito J, Iwabuchi Y, Nakazawa A, and Shimada H
- Subjects
- Male, Humans, Child, Preschool, Neoplasm, Residual diagnosis, Fluorodeoxyglucose F18, Positron-Emission Tomography methods, Radiopharmaceuticals, Positron Emission Tomography Computed Tomography methods, Burkitt Lymphoma diagnostic imaging, Burkitt Lymphoma drug therapy
- Abstract
A 4-year-old boy with an abdominal mass extending from the spleen to the lower umbilicus was diagnosed with Burkitt lymphoma stage III. Because the fluorodeoxyglucose uptake on positron emission tomography (PET)-computed tomography of the residual splenic tumor remained elevated, splenectomy was performed. The PET-positive area was composed of inflammatory infiltrates, whereas the PET-negative area was composed of a viable tumor surrounded by necrotic or dying tumor cells. The residual tumor may have been false-negative for PET because of its poor proliferative potential. In this case, the comparison of PET-computed tomography and pathologic findings demonstrates the simultaneous presence of a false-positive inflammatory lesion and a false-negative residual tumor., Competing Interests: The authors declare no conflict of interest., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2023
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4. Sporadic Burkitt Lymphoma Involving the Orbit - A Report of Two Cases and Review of Literature.
- Author
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Saxena S, Koka K, Scott JX, and Mukherjee B
- Subjects
- Child, Humans, Orbit pathology, Biopsy, Immunohistochemistry, Burkitt Lymphoma diagnostic imaging, Burkitt Lymphoma drug therapy, Exophthalmos diagnosis
- Abstract
Burkitt lymphoma (BL) is an aggressive, rapidly growing B-cell non-Hodgkin lymphoma found predominantly in children and has three clinical subtypes. The sporadic subtype, seen in non-endemic areas, typically presents as an abdominal mass. Primary orbital involvement is rarely reported. We report two cases of sporadic orbital BL manifesting as unilateral rapidly progressive proptosis with orbit being the initial site of presentation. Following an incision biopsy, BL was confirmed on histopathology and immunohistochemistry. Both patients demonstrated a remarkable improvement with systemic chemotherapy. Burkitt lymphomas grow rapidly with the potential for vision loss. Albeit rare, clinicians should be aware of this entity as timely diagnosis and initiation with chemotherapy display a dramatic response.
- Published
- 2023
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5. Burkitt's lymphoma in the adult as an unusual cause of large bowel obstruction.
- Author
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Díaz García A, García Niebla J, Reyes Correa B, Pérez Álvarez AD, and Barrera Gómez MÁ
- Subjects
- Humans, Adult, Burkitt Lymphoma complications, Burkitt Lymphoma diagnostic imaging, Intestinal Obstruction diagnostic imaging, Intestinal Obstruction etiology, Intussusception diagnostic imaging, Intussusception etiology
- Abstract
Bowel obstruction is an uncommon clinical presentation in Burkitt´s lymphoma, specially in adults. This type of lymphoma is classified within B-cell non-Hodgkin´s lymphomas, which is characterized by its aggressiveness and quickly tumoral growth. The clinical presentation related to the gastrointestinal tract is unusual, but it can be presented as intussusception, obstruction or ischemic perforation. Here we describe a case of Burkitt´s lymphoma with bowel obstruction as a clinical debut.
- Published
- 2023
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6. Case of HIV presenting as retinal artery occlusion with further complications of Burkitt's lymphoma and CMV retinitis.
- Author
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Karande S, Khalsa A, and Kelgaonkar A
- Subjects
- Humans, Burkitt Lymphoma diagnosis, Burkitt Lymphoma diagnostic imaging, Cytomegalovirus Retinitis complications, Cytomegalovirus Retinitis diagnosis, Cytomegalovirus Retinitis drug therapy, Retinal Artery Occlusion complications, HIV Infections complications, HIV Infections drug therapy
- Abstract
Competing Interests: Competing interests: None declared.
- Published
- 2023
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7. The Usefulness of Total Colonoscopy for Intussusception with Burkitt Lymphoma.
- Author
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Ito Y, Kakiuchi T, Hidaka H, Ikeuchi A, Miyahara K, and Tashiro K
- Subjects
- Humans, Tomography, X-Ray Computed, Colonoscopy, Burkitt Lymphoma diagnosis, Burkitt Lymphoma diagnostic imaging, Intussusception diagnostic imaging, Intussusception etiology
- Published
- 2023
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8. Primary gastric Burkitt lymphoma with multiple hepatic metastases.
- Author
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Mita H, Adachi Y, Ishii Y, and Endo T
- Subjects
- Humans, Burkitt Lymphoma diagnostic imaging, Burkitt Lymphoma pathology, Stomach Neoplasms pathology, Liver Neoplasms
- Abstract
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
- Published
- 2023
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9. Urgent Excision of Primary Intracardiac Burkitt Lymphoma in a Child.
- Author
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Ashry A, Tarmahomed A, Johns M, Samaddar A, Kutty R, Dhannapuneni R, Lotto A, Duong P, and Guerrero R
- Subjects
- Female, Humans, Child, Echocardiography, Heart Atria surgery, Heart Atria pathology, Dyspnea, Burkitt Lymphoma diagnostic imaging, Burkitt Lymphoma surgery, Atrial Appendage
- Abstract
A 9-year-old girl presented with a recent history of shortness of breath, fatigue, visual disturbances, and gastrointestinal symptoms. Echocardiography demonstrated three large intracardiac masses in the right and left atria protruding into the mitral and tricuspid valve orifices causing bilateral inflow obstruction. She underwent urgent surgical excision of the masses. Histology revealed rare intracardiac Burkitt's Lymphoma.
- Published
- 2023
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10. Intestinal occlusion due to Burkitt lymphoma: an unusual cause.
- Author
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Sierra Gabarda O, Aguirre Portu N, Casas Deza D, Lamuela Calvo LJ, Betoré Glaría E, Julián Gomara B, Abecia Martínez EI, and Fernández Bonilla EM
- Subjects
- Female, Humans, Adult, Abdominal Pain etiology, Burkitt Lymphoma complications, Burkitt Lymphoma diagnostic imaging, Lymphoma, B-Cell pathology, Intestinal Obstruction diagnostic imaging, Intestinal Obstruction etiology
- Abstract
We present the case of a 37-year-old Caucasian woman, with no history of interest, who came to the emergency room for an occlusive condition of 24 hours' evolution. The patient reported a weight loss of 12 kg in the last month, as well as the appearance of a lump in the left breast in the last week. A chest-abdominal CT scan revealed multiple solid-appearing nodules in the left breast, a metastatic liver lesion, and a tumor-like mass in the right iliac fossa measuring 90x60 mm. A biopsy of the breast lesion revealed a diffuse architectural pattern with destruction of the parenchyma and irregular medium-large cellularity with intense and diffuse expression of CD20, CD10 and Bcl6 and a proliferative index of practically 100%, consistent with lymphoma. Burkitt stage IV. Intestinal obstruction constitutes about 15% of hospital admissions for abdominal pain, representing a significant cause of hospital mortality. Although the most common causes of small bowel obstruction are benign (adhesions, hernias), intraluminal lesions such as inflammatory bowel disease or neoplasms are well-established causes associated with this clinical picture. Lymphomas constitute 25% of cases of intestinal obstruction of neoplastic origin; among them, Burkitt lymphoma is a rare type of B-cell lymphoma characterized by rapid and aggressive cell growth, the most common initial involvement of which is located at the abdominal and extra-nodal level.
- Published
- 2022
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11. Primary Burkitt lymphoma of the thyroid associated with Hashimoto's thyroiditis.
- Author
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Bergsma P, Riemenschnitter C, Gruber-Mösenbacher U, and Brand Y
- Subjects
- Aged, Female, Humans, Ultrasonography, Burkitt Lymphoma diagnostic imaging, Burkitt Lymphoma pathology, Burkitt Lymphoma surgery, Hashimoto Disease diagnostic imaging, Hashimoto Disease pathology, Hashimoto Disease surgery, Thyroid Neoplasms diagnostic imaging, Thyroid Neoplasms pathology, Thyroid Neoplasms surgery
- Abstract
Primary Burkitt lymphoma of the thyroid is an extremely rare entity with only a few reported cases. A female patient in her 70s with Hashimoto's thyroiditis presented with a 2-month history of progressive left-sided neck swelling. Ultrasound examination revealed a multinodular goitre and fine needle aspiration (FNA) showed no signs of malignancy. The rapid growth of the thyroid mass raised the concern of a lymphoproliferative process. After left thyroid lobectomy and histopathological examination, the diagnosis of Burkitt lymphoma was made and the patient was included in a randomised study providing chemotherapy following a dose adjusted EPOCH-R regimen. Clinical remission was reached after 6 cycles of chemotherapy. There were no signs of relapse on follow-up, 1.5 years after the end of the treatment. Fast growing thyroid nodules in HT warrant a high index of suspicion. Despite no signs of malignancy after FNA cytology, these nodules may need further investigations., Competing Interests: Competing interests: None declared., (© BMJ Publishing Group Limited 2022. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2022
- Full Text
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12. A Life-Saving Early Diagnosis of Burkitt Lymphoma: The Role of a Dentist.
- Author
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Sodnom-Ish B, Seo MH, Huh KH, Myoung H, and Kim SM
- Subjects
- Abscess, Adult, Dentists, Early Diagnosis, Humans, Male, Mandible pathology, Burkitt Lymphoma diagnostic imaging
- Abstract
Abstract: Burkitt lymphoma (BL) is a subtype of Non-Hodgkin lymphoma, considered one of the fastest growing human tumors. Due to the highly aggressive nature of BL, a prompt diagnosis and aggressive chemotherapeutic treatment are essential. However, the clinical features of BL often can mimic periodontal disease or dentoalveolar abscess. The aim of this study is to present a case of a 31-year-old male patient who was referred to the department of oral and maxillofacial surgery for severe neurosensory disturbance and pain in the lower jaw. He was misdiagnosed with periodontitis and dental abscess at the local clinic. Based on radiographic findings, he was suspected of hematopoietic malignancy. He was referred to the department of hemato-oncology and diagnosed with BL. This case highlights the essential life-saving role of a maxillofacial surgeon in the early diagnosis of a rare malignancy., Competing Interests: The authors report no conflicts of interest., (Copyright © 2021 by Mutaz B. Habal, MD.)
- Published
- 2022
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13. Gastroduodenal Burkitt's lymphoma: a rare cause of epigastric pain and diarrhea.
- Author
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Martínez-Acitores de la Mata D, Juanmartiñena Fernández JF, León Brito H, and Campillo Arregui A
- Subjects
- Abdominal Pain etiology, Biopsy, Diarrhea etiology, Humans, Male, Middle Aged, Burkitt Lymphoma complications, Burkitt Lymphoma diagnostic imaging
- Abstract
A 54-year-old male with a medical history of diabetes mellitus type 2 and tonsil cancer treated with radiochemotherapy years previously was admitted to hospital due to one-month progressive diarrhea, epigastric pain and 14-kg weight loss. Laboratory tests revealed mild anemia (Hb 10.8 g/dl). Upper endoscopy (UE) showed multiple ulcerated lesions with raised edges and a hard consistency on biopsy, being more evident at the duodenum and with a lower frequency and smaller diameter in the stomach.
- Published
- 2022
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14. Burkitt Lymphoma/Leukemia Presented on 68Ga-Pentixafor and 18F-FDG PET/CT.
- Author
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Chen Z, Xue Q, Huang C, Yao S, and Miao W
- Subjects
- Adolescent, Coordination Complexes, Fluorodeoxyglucose F18, Humans, Male, Peptides, Cyclic, Positron Emission Tomography Computed Tomography, Burkitt Lymphoma diagnostic imaging, Leukemia
- Abstract
Abstract: An 18-year-old man with newly diagnosed Burkitt lymphoma/leukemia was referred for 18F-FDG and 68Ga-Pentixafor PET/CT. 68Ga-Pentixafor PET/CT revealed similar radioactivity uptake pattern to the 18F-FDG PET/CT in superior phrenic lymph node, ascending colon, ileocecum, peritoneal, marrow, and spleen. This case highlighted that it might be interesting to further investigate the role of 68Ga-Pentixafor PET/CT imaging in staging, treatment evaluation, and especially the feasibility of CXCR4-directed radioligand therapy in Burkitt lymphoma with positive expression of CXCR4., Competing Interests: Conflicts of interest and sources of funding: This study was funded in part by the National Natural Science Foundation of China (81971651), Natural Science Foundation of Fujian (2019J01454, 2020J05249), and Fujian Provincial Health Commission Science and Technology Programme (2020GGA045, 2020QNA054). The authors declare no conflicts of interest., (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2022
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15. Clinical presentation of gastric Burkitt lymphoma presenting with paraplegia and acute pancreatitis: A case report.
- Author
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Lin Y, Pan YH, Li MK, Zong XD, Pan XM, Tan SY, and Guo YW
- Subjects
- Acute Disease, Humans, Male, Middle Aged, Paraplegia etiology, Burkitt Lymphoma complications, Burkitt Lymphoma diagnostic imaging, Burkitt Lymphoma drug therapy, Pancreatitis complications, Pancreatitis diagnostic imaging, Stomach Neoplasms complications, Stomach Neoplasms diagnostic imaging
- Abstract
Background: The incidence of gastric Burkitt lymphoma (BL), presenting as paraplegia and acute pancreatitis, is extremely low. BL is a great masquerader that presents in varied forms and in atypical locations, and it is prone to misdiagnosis and missed diagnosis. The prognosis of BL remains poor because of the difficulty in early diagnosis and the limited advances in chemotherapy., Case Summary: A 53-year-old man was referred to our hospital from the local county hospital due to abdominal pain for two weeks and weakness in the lower extremities for one day. Magnetic resonance imaging of the abdomen and lumbar spine showed a swollen pancreas and gallbladder, with peripancreatic exudation and liquid collection, indicating acute pancreatitis and acute cholecystitis. Additionally, we observed abnormally thickened lesions of the gastric wall, multiple enlarged retroperitoneal lymph nodes and a well-demarcated, posterolateral extradural mass lesion between T9 and T12, with extension through the spinal foramen and definite bony destruction, suggesting metastasis in gastric malignancy. Subsequent whole-body positron emission tomography/computed tomography examination showed multifocal malignant lesions in the stomach, pancreas, gallbladder, bone, bilateral supraclavicular fossa, anterior mediastinum, bilateral axillary and retroperitoneal lymph nodes. Gastroduodenal endoscopy revealed primary BL with massive involvement of the gastric body and duodenum. The patient refused chemotherapeutic treatment and died one week later due to upper gastrointestinal hemorrhage. Afterward, we reviewed the characteristics of 11 patients with BL involving the stomach, pancreas or spinal cord., Conclusion: Clinicians should be aware that BL can be the potential cause of acute pancreatitis or a rapidly progressive spinal tumor with accompanying paraplegia. For gastric BL, gastroscopy biopsies and pathology are necessary for a definite diagnosis., Competing Interests: Conflict-of-interest statement: The authors declare that they have no conflicts of interest., (©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.)
- Published
- 2021
- Full Text
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16. Value of baseline and end of chemotherapy 18 F-FDG PET/CT in pediatric patients with Burkitt lymphoma.
- Author
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Xiao Z, Mo Y, Long W, Li R, Li X, Wei Y, Fan W, and Zhang X
- Subjects
- Child, Glycolysis, Humans, Positron Emission Tomography Computed Tomography methods, Positron-Emission Tomography, Prognosis, Radiopharmaceuticals, Retrospective Studies, Tumor Burden, Burkitt Lymphoma diagnostic imaging, Burkitt Lymphoma drug therapy, Fluorodeoxyglucose F18
- Abstract
The aim of this study was to analyze whether the baseline metabolic parameters of
18 F-FDG PET/CT in pediatric patients with Burkitt lymphoma (BL) can predict treatment response and prognosis. We retrospectively analyzed 68 pediatric patients with BL who underwent PET/CT before treatment. PET images were analyzed semi-quantitatively by measuring the maximum standardized uptake (SUVmax), total metabolic tumor volume (tMTV), and total lesion glycolysis (TLG). Survival curves were plotted according to the Kaplan-Meier method. Univariate and multivariate Cox proportional hazards regression models were used to assess the relation between potential variables and outcomes. tMTV and TLG were significantly lower in patients with complete response compared with those with partial response at the end of treatment. PET metabolic parameters (tMTV and TLG) were the independent prognostic values for outcome. TMTV and TLG were significantly connected with treatment response and prognosis in pediatric with BL.- Published
- 2021
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17. Burkitt lymphoma of the nasopharynx causing life-threatening airway obstruction: A case report.
- Author
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Goel AN, Filimonov A, Teruya-Feldstein J, Salib C, Rousso JJ, Hackett AM, Rothschild MA, and Wanna GB
- Subjects
- Acute Disease, Airway Obstruction diagnostic imaging, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Burkitt Lymphoma diagnosis, Burkitt Lymphoma diagnostic imaging, Child, Cyclophosphamide administration & dosage, Doxorubicin administration & dosage, Dyspnea diagnostic imaging, Dyspnea etiology, Dyspnea surgery, Early Detection of Cancer, Emergencies, Humans, Male, Methotrexate administration & dosage, Nasopharyngeal Neoplasms diagnosis, Nasopharyngeal Neoplasms diagnostic imaging, Positron-Emission Tomography, Prednisone administration & dosage, Rituximab administration & dosage, Tomography, X-Ray Computed, Treatment Outcome, Vincristine administration & dosage, Airway Obstruction etiology, Airway Obstruction surgery, Burkitt Lymphoma complications, Burkitt Lymphoma drug therapy, Nasopharyngeal Neoplasms complications, Nasopharyngeal Neoplasms drug therapy, Tracheostomy methods
- Abstract
Objective: To describe a case of Burkitt lymphoma (BL) in a child manifesting with acute airway obstruction. To review available literature on the clinical features and characteristic presentation of this disease., Methods: Case report with literature review., Results: We present the case of an 8-year-old boy with nasopharyngeal BL manifesting initially as sore throat, nasal congestion, and snoring that progressed to dyspnea and, ultimately, acute airway obstruction requiring emergent tracheostomy. The child was treated with intensive chemotherapy and achieved complete response., Conclusion: This case highlights the importance of maintaining high clinical suspicion when evaluating common otolaryngologic symptoms and emphasizes the potential for Burkitt lymphoma to cause rapid patient deterioration., (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Published
- 2021
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18. Endoscopic detection of the lead-point of intussusception associated with ileal Burkitt's lymphoma.
- Author
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Kanamaru K, Hisamatsu C, Osuga T, and Ikura Y
- Subjects
- Burkitt Lymphoma complications, Burkitt Lymphoma diagnostic imaging, Child, Humans, Ileal Neoplasms complications, Ileal Neoplasms diagnostic imaging, Male, Tomography, X-Ray Computed, Burkitt Lymphoma pathology, Ileal Neoplasms pathology, Intussusception etiology
- Abstract
Competing Interests: Declaration of Competing Interest None declared.
- Published
- 2021
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19. A case of Burkitt's lymphoma detected with tumor cells clustering in urine.
- Author
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Orita M, Nakajima Y, Tajika Y, Yasuda K, Noguchi A, Kazama T, and Imura J
- Subjects
- Adult, Burkitt Lymphoma diagnostic imaging, Burkitt Lymphoma urine, Female, Humans, Burkitt Lymphoma pathology
- Published
- 2021
- Full Text
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20. Testicular FDG-PET/CT uptake threshold in aggressive lymphomas.
- Author
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Higgins A, Kim H, Harper L, Habermann TM, Nowakowski GS, Thompson CA, Johnston P, Witzig TE, Allmer C, Maurer MJ, Cerhan JR, Young JR, and Thanarajasingam G
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Burkitt Lymphoma diagnostic imaging, Burkitt Lymphoma pathology, Humans, Lymphoma, Large B-Cell, Diffuse pathology, Lymphoma, T-Cell, Peripheral diagnostic imaging, Lymphoma, T-Cell, Peripheral pathology, Male, Middle Aged, Neoplasm Invasiveness diagnostic imaging, Neoplasm Invasiveness pathology, Testis metabolism, Testis pathology, Young Adult, Fluorine Radioisotopes pharmacokinetics, Fluorodeoxyglucose F18 pharmacokinetics, Lymphoma, Large B-Cell, Diffuse diagnostic imaging, Positron Emission Tomography Computed Tomography, Radiopharmaceuticals pharmacokinetics, Testis diagnostic imaging
- Published
- 2021
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21. Wernicke encephalopathy in a patient with Burkitt lymphoma with typical and atypical findings on MRI.
- Author
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Barradas P, Esteireiro AS, Carvalho S, and Brito MJ
- Subjects
- Humans, Magnetic Resonance Imaging, Burkitt Lymphoma complications, Burkitt Lymphoma diagnostic imaging, Burkitt Lymphoma drug therapy, Korsakoff Syndrome, Wernicke Encephalopathy diagnostic imaging, Wernicke Encephalopathy etiology
- Abstract
Competing Interests: Competing interests: None declared.
- Published
- 2021
- Full Text
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22. Endoscopic ultrasound-guided diagnosis of Helicobacter pylori-associated gastric Burkitt's lymphoma in an adolescent patient: a rare case.
- Author
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Ruan W, Febo-Rodriguez L, Daignault C, Gulati N, Narine K, Sher AC, Elghetany MT, Cortes-Santiago N, Fishman DS, and Olive AP
- Subjects
- Adolescent, Female, Humans, Ultrasonography, Interventional, Burkitt Lymphoma diagnostic imaging, Burkitt Lymphoma microbiology, Helicobacter Infections complications, Helicobacter pylori, Stomach Neoplasms diagnostic imaging, Stomach Neoplasms microbiology
- Abstract
Primary gastric Burkitt's lymphoma (BL) is rare in the pediatric population. Furthermore, the association of Burkitt's lymphoma with Helicobacter pylori is not well defined. We report a case of primary gastric Burkitt's lymphoma associated with Helicobacter pylori diagnosed in a pediatric patient. This diagnosis was made with the aid of endoscopic ultrasound (EUS)-guided fine-needle biopsy (FNB). This is one of the first pediatric cases of EUS-guided FNB for the diagnosis of H. pylori-associated gastric BL.
- Published
- 2021
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23. Comparison between children and adults intussusception. Description of two cases and review of literature.
- Author
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Fiordaliso M, Panaccio P, Costantini R, and De Marco AF
- Subjects
- Adult, Age Factors, Child, Preschool, Colectomy, Humans, Ileocecal Valve diagnostic imaging, Ileocecal Valve surgery, Male, Burkitt Lymphoma complications, Burkitt Lymphoma diagnostic imaging, Burkitt Lymphoma surgery, Cecal Diseases complications, Cecal Diseases diagnostic imaging, Cecal Diseases surgery, Ileal Diseases complications, Ileal Diseases diagnostic imaging, Ileal Diseases surgery, Intussusception diagnostic imaging, Intussusception etiology, Intussusception surgery
- Abstract
Introduction: Intussusception is a common condition in children, it is rare in adults. Adult intussusception differs from pediatric intussusception in various respects, including etiology clinical characteristics and therapy., Methods: We present and discuss a new case of intussusception in children and adults., Results: In child the Barium Enema x-ray examination is identified an endoluminal filling defect to refer to the apex of the invaginated loop at the rectal level, with slow ascent during the progressive injection of the radiopaque contrast medium. At the end of the procedure, incomplete reduction of the picture is documented. The patient undergoes emergency surgery where the presence of an ileo-ceco-colic invagination is documented. Intussusception is reduced by taxis. In the adult laparoscopic right hemicolectomy was performed. High-grade B-cell Burkitt's lymphoma was confirmed by immunohistochemistry., Discussion: In contrast to intussusceptions in children, in the adult population, a demonstrable etiology is found in most of the cases. In adults surgery is always indicated. The non-invasive resolutive intervention most commonly used in the child and best known consists in the rectal introduction of a radiopaque contrast medium (air or barium) at controlled pressure until., Conclusions: Although intussusceptions occur at all ages, there are major differences in the clinical presentation, diagnostic approach, and management between pediatric and adult populations. Intussusception is remarkably different in these two age groups and it must be approached from a different clinical perspective., Key Words: Intussusception in children, Intussusception in adults, Intussusception symptoms, Radiology and treatment.
- Published
- 2021
24. Treatment response to idelalisib in a patient with immunodeficiency-associated Burkitt lymphoma harboring a PIK3CA H1047R mutation.
- Author
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Bleckmann A, Dierks S, Schildhaus HU, Hellige N, Bacher U, Trümper L, and Wulf G
- Subjects
- Aged, Burkitt Lymphoma diagnostic imaging, Burkitt Lymphoma virology, Comorbidity, HIV Infections complications, High-Throughput Screening Assays, Humans, Magnetic Resonance Imaging, Male, Mutation, Recurrence, Tumor Suppressor Protein p53 genetics, Antineoplastic Agents therapeutic use, Burkitt Lymphoma drug therapy, Burkitt Lymphoma genetics, Class I Phosphatidylinositol 3-Kinases genetics, Purines therapeutic use, Quinazolinones therapeutic use
- Published
- 2021
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25. Advanced Burkitt's lymphoma in a man presenting with a breast tumor: A case report.
- Author
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Lai CC, Sheen-Chen SM, Chang IW, and Wang WK
- Subjects
- Humans, Male, Breast Neoplasms diagnostic imaging, Burkitt Lymphoma diagnostic imaging, Burkitt Lymphoma drug therapy, Lymphoma
- Published
- 2020
- Full Text
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26. Visible and near-infrared hyperspectral imaging techniques allow the reliable quantification of prognostic markers in lymphomas: A pilot study using the Ki67 proliferation index as an example.
- Author
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Willenbacher E, Brunner A, Willenbacher W, Zelger B, Wolf D, Rogge D, Tappert M, and Pallua JD
- Subjects
- Burkitt Lymphoma diagnostic imaging, Burkitt Lymphoma pathology, Cell Proliferation, Cost-Benefit Analysis, Humans, Hyperspectral Imaging economics, Infrared Rays, Lymphoma, Follicular diagnostic imaging, Lymphoma, Follicular pathology, Lymphoma, Large B-Cell, Diffuse diagnostic imaging, Lymphoma, Large B-Cell, Diffuse pathology, Lymphoma, Non-Hodgkin mortality, Lymphoma, Non-Hodgkin pathology, Mitotic Index, Pilot Projects, Prognosis, Signal Processing, Computer-Assisted, Antigens, Neoplasm analysis, Hyperspectral Imaging methods, Ki-67 Antigen analysis, Lymphoma, Non-Hodgkin diagnostic imaging
- Abstract
In this study, we examined the suitability of visible and infrared (Vis-NIR) hyperspectral imaging (HSI) for the quantification of prognostic markers in non-Hodgkin lymphoma on the example of the Ki67 proliferation index. Ki67 quantification was done on six follicular lymphomas (FLs) and 12 diffuse large B-cell lymphomas (DLBCLs) by applying classic immunohistochemistry. The Ki67 index was comparatively assessed visually, using HSI-based quantification and a digital imaging analysis (DIA) platform. There was no significant difference between visual assessment (VA), DIA, and HSI in FLs. For DLBCLs, VA resulted in significantly higher Ki67 values than HSI (p = 0.023) and DIA (p = 0.006). No such difference was seen comparing analysis by HSI and DIA (p = 0.724). Cohen's κ revealed a "substantial correlation" of Ki67 values for HSI and DIA in FLs and DLBCLs (κ = 0.667 and 0.657). Here we provide the first evidence that, comparably to traditional DIA, HSI can be used reliably to quantify protein expression, as exemplified by the Ki67 proliferation index. By covering the near-infrared spectrum, HSI might offer additional information on the biochemical composition of pathological specimens, although our study could not show that HSI is clearly superior to conventional DIA. However, the analysis of multiplex immunohistochemistry might benefit from such an approach, especially if overlapping immunohistochemical reactions were possible. Further studies are needed to explore the impact of this method on the analysis and quantification of multiple marker expression in pathological specimens., (Copyright © 2020 ISEH -- Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.)
- Published
- 2020
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27. A 35-year-old woman with an atypical course of Burkitt lymphoma.
- Author
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Jarosińska A, Steinhof K, Wosiewicz P, Pająk J, Kajor M, and Holecki M
- Subjects
- Adult, Diagnosis, Differential, Female, Humans, Burkitt Lymphoma diagnostic imaging, Burkitt Lymphoma drug therapy
- Published
- 2020
- Full Text
- View/download PDF
28. A Case of Burkitt’s Lymphoma Mimicking Peritonitis Carcinomatosa
- Author
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Büyüktaş D, Örnek S, Tecimer T, and Ferhanoğlu B
- Subjects
- Adult, Burkitt Lymphoma drug therapy, Humans, Male, Peritoneal Neoplasms drug therapy, Positron Emission Tomography Computed Tomography, Burkitt Lymphoma diagnostic imaging, Peritoneal Neoplasms diagnostic imaging
- Published
- 2020
- Full Text
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29. Recurrent small bowel obstruction caused by Burkitt lymphoma in an elderly man: a case report and review of the literature.
- Author
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Kasparian S, Burns E, Shehabeldin A, Awar M, and Pingali SR
- Subjects
- Abdominal Pain, Aged, Child, Humans, Intestine, Small diagnostic imaging, Male, Neoplasm Recurrence, Local complications, Neoplasm Recurrence, Local diagnostic imaging, Burkitt Lymphoma complications, Burkitt Lymphoma diagnostic imaging, Intestinal Obstruction diagnostic imaging, Intestinal Obstruction etiology, Intestinal Obstruction surgery
- Abstract
Background: Acute small bowel obstruction is a common surgical emergency usually caused by abdominal adhesions, followed by intraluminal tumors from metastatic disease. Although lymphomas have been known to cause bowel obstruction, Burkitt lymphoma is seldom reported to induce an obstruction in the adult population., Case Presentation: A 78-year-old Hispanic man with a history of abdominal interventions presented to our hospital with abdominal pain. Computed tomography revealed a partial small bowel obstruction attributed to local inflammation or adhesions. Medical management with bowel rest and nasogastric decompression resulted in resolution of symptoms and quick discharge. He returned 2 days later with worsening abdominal pain. Repeat imaging showed progression of the partial small bowel obstruction, but with an additional 1.6-cm nodular density abutting the anterior aspect of the gastric antrum and lobulated anterior gastric antral wall thickening. He was taken to the operating room, where several masses were found. Intraoperative frozen sections were consistent with lymphoma, and pathology later revealed Burkitt lymphoma. Disease was found on both sides of the diaphragm by positron emission tomography. After the initial resection and adjuvant chemotherapy, the patient is alive and well about 14 months after resection., Conclusions: Small bowel obstruction is uncommonly due to Burkitt lymphoma in the geriatric population and is more frequently seen in the pediatric and young adult populations. Burkitt lymphoma is very aggressive with rapid cell turnover leading to significant morbidity. The rapid recurrence of an acute abdominal process should prompt an investigation for a more sinister cause such as malignancy.
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- 2020
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30. Giant primary breast Burkitt's lymphoma demonstrated on FDG PET/CT.
- Author
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Liu Y
- Subjects
- Female, Fluorodeoxyglucose F18, Humans, Positron Emission Tomography Computed Tomography, Positron-Emission Tomography, Breast Neoplasms diagnostic imaging, Burkitt Lymphoma diagnostic imaging
- Published
- 2020
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31. Gastrointestinal: Burkitt lymphoma showing multiple tumorous lesions in the gastrointestinal tract.
- Author
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Harada A, Torisu T, and Esaki M
- Subjects
- Adult, Burkitt Lymphoma therapy, Endoscopy, Digestive System, HIV Infections, Humans, Male, Positron-Emission Tomography, Burkitt Lymphoma diagnostic imaging, Burkitt Lymphoma pathology, Gastrointestinal Tract diagnostic imaging, Gastrointestinal Tract pathology
- Published
- 2020
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32. Rituximab conjugated iron oxide nanoparticles for targeted imaging and enhanced treatment against CD20-positive lymphoma.
- Author
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Song L, Chen Y, Ding J, Wu H, Zhang W, Ma M, Zang F, Wang Z, Gu N, and Zhang Y
- Subjects
- Animals, Burkitt Lymphoma diagnostic imaging, Cell Proliferation drug effects, Cell Survival drug effects, Drug Screening Assays, Antitumor, Female, Humans, Magnetic Resonance Imaging, Male, Materials Testing, Mice, Mice, Inbred NOD, Mice, SCID, Neoplasms, Experimental diagnostic imaging, Neoplasms, Experimental drug therapy, Particle Size, Rituximab chemistry, Surface Properties, Tumor Cells, Cultured, Burkitt Lymphoma drug therapy, Magnetic Iron Oxide Nanoparticles chemistry, Rituximab pharmacology
- Abstract
Since its launch in 1997, rituximab (RTX) has extensively improved the treatment of CD20-positive follicular and diffuse large B cell non-Hodgkin lymphoma (NHL). The application of RTX is limited usually by the failed therapy because of resistance. Iron oxide nanomaterials have been explored for cancer detection and treatment in recent years. In this study, a multivalent nanoprobe comprising one Fe
3 O4 nanoparticle and several RTX antibodies was constructed for the targeted imaging and enhanced treatment of NHL. Poly(ethylene glycol) (PEG)-coated Fe3 O4 nanoparticles were fabricated via a thermal decomposition method and ligand exchange. RTX was conjugated onto the surface of the Fe3 O4 -PEG nanoparticles to form Fe3 O4 -PEG-nAb (n = 2, 5 or 8) multivalent nanoprobes. These multivalent nanoprobes, with a core size of approximately 11 nm and a hydrodynamic diameter of about 22 nm, showed colloidal stability in buffer solution. The r2 relaxation rate of Fe3 O4 -PEG-nAb was similar to that of Fe3 O4 -PEG (309 ± 3.08 mM-1 s-1 ). The specificity of nanoprobes for CD20-positive Raji cells was assessed on a clinical magnetic resonance imaging scanner. The receptor binding site of one multivalent nanoprobe was more than that of one RTX, exhibiting valence-dependent induction of Raji cell apoptosis, and this effect could be enhanced by complement activation from blood serum added. A similar activity was observed in vivo in a NHL xenograft model. The multivalent nanoprobe treatment significantly reduced tumor burden and enhanced survival in comparison to the RTX group. Our studies demonstrate that the appropriate design and preparation of anticancer antibody-nanoparticle conjugates enable the generation of improved anticancer nanomedicines and could thus provide an efficient cancer theranostic strategy.- Published
- 2020
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33. Generation of Tumor Cells Expressing Firefly Luciferase (fLuc) to Evaluate the Effectiveness of CAR in a Murine Model.
- Author
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de Souza Fernandes Pereira M, Fantacini DMC, and Picanço-Castro V
- Subjects
- Animals, Burkitt Lymphoma diagnostic imaging, Burkitt Lymphoma etiology, Burkitt Lymphoma pathology, Burkitt Lymphoma therapy, Cell Line, Tumor, Disease Models, Animal, Humans, Luciferases, Firefly genetics, Mice, Molecular Imaging methods, Receptors, Antigen, T-Cell genetics, Receptors, Chimeric Antigen genetics, Transduction, Genetic, Treatment Outcome, Xenograft Model Antitumor Assays, Gene Expression, Genes, Reporter, Immunotherapy, Adoptive methods, Receptors, Antigen, T-Cell metabolism, Receptors, Chimeric Antigen metabolism, T-Lymphocytes immunology, T-Lymphocytes metabolism
- Abstract
Immunotherapy has been showed as a promisor treatment, in special for hematological diseases. Chimeric antigen receptor T cells (CARs) which are showing satisfactory results in early-phase cancer clinical trials can be highlighted. However, preclinical models are critical steps prior to clinical trial. In this way, a well-established preclinical model is an important key in order to confirm the proof of principle. For this purpose, in this chapter will be pointed the methods to generate tumor cells expressing firefly Luciferase. In turn, these modified cells will be used to create a subcutaneous and a systemic murine model of Burkitt's lymphoma in order to evaluate the effectiveness of CAR-T.
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- 2020
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34. A case series of unusual presentations of Burkitt's lymphoma.
- Author
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Dashottar S, Sunita BS, Singh RK, Rana V, Suhag V, and Singh AK
- Subjects
- Abdominal Neoplasms diagnostic imaging, Adult, Burkitt Lymphoma diagnostic imaging, Child, Preschool, Humans, Male, Prognosis, Retrospective Studies, Young Adult, Abdominal Neoplasms pathology, Burkitt Lymphoma pathology, Tomography, X-Ray Computed methods, Ultrasonography methods
- Abstract
Context: Burkitt's lymphoma (BL) is one of the fastest growing malignancies. It is the most common subtype of Non-Hodgkin's lymphoma in childhood. It has three major subtypes - endemic, sporadic, and immunodeficiency-associated types., Aims: This study aims to study the clinicomorphologic features of this disease entity and to find optimal imaging technique for such cases., Setting and Design: A retrospective observational study in a tertiary care center of academic and research potential., Subjects and Methods: We are presenting three unusual cases of sporadic type of BL who presented initially as localized right iliac fossa mass mimicking as acute appendicitis. Initially, localized presentation progressed to diffuse abdominal mass lesions causing intestinal obstruction., Results: These cases had emphasized the importance of accurate diagnosis by the ultrasonography (USG) or computed tomography (CT) scan for early diagnosis so as to manage such cases simply by early appropriate medical treatment., Conclusion: In this article, we will discuss the clinical and imaging features of BL with the role of USG, CT scan and positron emission tomography/CT in the abdominopelvic imaging of pediatric patients., Competing Interests: None
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- 2020
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35. A Review of Viral-Related Malignancies and the Associated Imaging Findings.
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Consul N, Menias CO, Lubner MG, Katabathina VS, Chahinian RA, Mansour J, and Elsayes KM
- Subjects
- Anus Neoplasms diagnostic imaging, Anus Neoplasms virology, Burkitt Lymphoma diagnostic imaging, Burkitt Lymphoma virology, Carcinoma, Hepatocellular diagnostic imaging, Carcinoma, Hepatocellular virology, Female, Hodgkin Disease diagnostic imaging, Hodgkin Disease virology, Humans, Liver Neoplasms diagnostic imaging, Liver Neoplasms virology, Male, Oropharyngeal Neoplasms diagnostic imaging, Oropharyngeal Neoplasms virology, Penile Neoplasms diagnostic imaging, Penile Neoplasms virology, Sarcoma, Kaposi diagnostic imaging, Sarcoma, Kaposi virology, Uterine Cervical Neoplasms diagnostic imaging, Uterine Cervical Neoplasms virology, Neoplasms diagnostic imaging, Neoplasms virology, Virus Diseases complications
- Abstract
OBJECTIVE. Imaging plays an important role in the diagnosis and staging of malignancies. Many common lymphoproliferative and other solid tumor malignancies can be viral-related. CONCLUSION. This review discusses the imaging findings that can be associated with common viral-induced malignancies. Knowledge of these imaging presentations can help narrow the differential diagnosis to reach a specific diagnosis through a precise workup and proper management.
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- 2020
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36. 18 F-FDG PET/CT in treatment response evaluation of Burkitt lymphoma: complete remission of a peritoneal super scan.
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Sachpekidis C, Exadaktylou P, Katsampoukas D, Moralidis E, and Arsos G
- Subjects
- Aged, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Cyclophosphamide therapeutic use, Doxorubicin therapeutic use, Humans, Male, Prednisone therapeutic use, Rituximab therapeutic use, Treatment Outcome, Vincristine therapeutic use, Burkitt Lymphoma diagnostic imaging, Burkitt Lymphoma drug therapy, Fluorodeoxyglucose F18, Peritoneum diagnostic imaging, Positron Emission Tomography Computed Tomography
- Abstract
Peritoneal lymphomatosis, defined as the disseminated intraperitoneal lymphomatous infiltration, is a rare presentation usually of non-Hodgkin lymphoma and is associated with aggressive histological subtypes of the malignancy. Recently, the term "peritoneal super scan" has been introduced in positron emission tomography/computed tomography (PET/CT) in a patient with Burkitt lymphoma to describe hypermetabolic lymphomatous involvement of the entire peritoneum, leading to suppression of tracer uptake in organs with otherwise normally increased fluorine-18-fluorodeoxyglucose (
18 F-FDG) uptake. Herein, we report on a patient with Burkitt lymphoma, initially presenting with a peritoneal super scan in PET/CT demonstrating complete metabolic response to R-CHOP (rituximab, cyclophosphamide, adriamycin, vincristine, and prednisolone) therapy.- Published
- 2020
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37. Ventricle-predominant primary CNS lymphomas: clinical, radiological and pathological evaluation of five cases and review of the literature.
- Author
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Ball MK, Morris JM, Wood AJ, Meyer FB, Kaszuba MC, and Raghunathan A
- Subjects
- Adult, Aged, Combined Modality Therapy, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Tomography, X-Ray Computed, Brain Neoplasms diagnostic imaging, Brain Neoplasms pathology, Brain Neoplasms therapy, Burkitt Lymphoma diagnostic imaging, Burkitt Lymphoma pathology, Burkitt Lymphoma therapy, Lymphoma, B-Cell diagnostic imaging, Lymphoma, B-Cell pathology, Lymphoma, B-Cell therapy, Lymphoma, B-Cell, Marginal Zone diagnostic imaging, Lymphoma, B-Cell, Marginal Zone pathology, Lymphoma, B-Cell, Marginal Zone therapy, Lymphoma, Large B-Cell, Diffuse diagnostic imaging, Lymphoma, Large B-Cell, Diffuse pathology, Lymphoma, Large B-Cell, Diffuse therapy
- Abstract
Primary central nervous system lymphomas (PCNSLs) are typically intraparenchymal. A subset of PCNSLs predominantly arises in the ventricles, with minimal parenchymal involvement. We review the clinical, radiological, and pathological features of ventricle-predominant PCNSLs (VP-PCNSLs) in 40 previously reported cases and report 5 additional cases. Including all cases of VP-PCNSLs (n = 45), 38% were diffuse large B-cell lymphomas (DLBCL), 11% were Burkitt lymphomas, 7% were MALT lymphomas, 4% were T-cell lymphomas, and 40% were lymphomas, not otherwise classified. VP-PCNSLs show rapid clinical progression. Patients present at a median age of 60.5 years. Unique clinical and radiological features distinguish them from other intraventricular tumors, including advanced age, edema, multifocality, hyperdensity, early and avid post-contrast enhancement, restricted diffusion, and positron emission tomography (PET) hypermetabolism. Including our cases, which were all DLBCL, and all previously reported DLBCL cases (n = 10), 8 of 10 show germinal center B-cell-like (GCB) phenotype, contrasting the high prevalence of non-germinal center B-cell-like (non-GCB) phenotype of parenchymal DLBCL PCNSLs. MYD88 L265P mutation was detected in three of our five cases. Ventricle-predominant PCNSLs are clinically and radiologically distinct, and the DLBCLs may be pathologically distinct. Further recognition of this entity may help to evaluate the role of therapies, possibly including surgical resection.
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- 2020
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38. The Early Results of Vertebral Pathological Compression Fracture of Extra- nodal Lymphoma with HIV-positive Patients Treated by Percutaneous Kyphoplasty.
- Author
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Sun S, Xu B, Zhang Q, Zhao CS, Ma R, He J, and Zhang Y
- Subjects
- Adult, Alkynes therapeutic use, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Antiretroviral Therapy, Highly Active methods, Benzoxazines therapeutic use, Burkitt Lymphoma diagnostic imaging, Burkitt Lymphoma drug therapy, Burkitt Lymphoma virology, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes drug effects, CD4-Positive T-Lymphocytes virology, Cyclophosphamide therapeutic use, Cyclopropanes therapeutic use, Doxorubicin therapeutic use, Female, Fractures, Compression diagnostic imaging, Fractures, Compression drug therapy, Fractures, Compression virology, HIV Infections diagnostic imaging, HIV Infections drug therapy, HIV Infections virology, Humans, Lamivudine therapeutic use, Lumbar Vertebrae diagnostic imaging, Lumbar Vertebrae drug effects, Lumbar Vertebrae surgery, Lumbar Vertebrae virology, Lymphoma, Large B-Cell, Diffuse diagnostic imaging, Lymphoma, Large B-Cell, Diffuse drug therapy, Lymphoma, Large B-Cell, Diffuse virology, Male, Middle Aged, Prednisone therapeutic use, Retrospective Studies, Rituximab therapeutic use, Spinal Fractures diagnostic imaging, Spinal Fractures drug therapy, Spinal Fractures virology, Tenofovir therapeutic use, Tomography, X-Ray Computed, Vincristine therapeutic use, Viral Load drug effects, Burkitt Lymphoma surgery, Cementoplasty methods, Fractures, Compression surgery, HIV Infections surgery, Kyphoplasty methods, Lymphoma, Large B-Cell, Diffuse surgery, Spinal Fractures surgery
- Abstract
Background: Vertebral pathological compression fracture involving extra-nodal lymphoma impacts negatively on the quality of life of HIV-positive patients. The choice of a safe and effective approach to palliative care in this condition remains a challenge., Objective: The purpose of this study was to investigate the safety and efficacy of percutaneous kyphoplasty (PKP) in the treatment of vertebral pathological compression fracture of extra-nodal lymphoma in HIV-positive patients., Methods: A retrospective analysis, from January 2016 to August 2019, was performed on 7 HIVpositive patients, 3 males and 4 females, with extra-nodal lymphoma with a vertebral pathological compression fracture. The patients were treated using percutaneous kyphoplasty in our hospital. Preoperative assessment of the patients was conducted regarding their hematological profile, biochemical indicators, liver and kidney function, blood coagulation function, CD4+T lymphocyte count and viral load. Subsequently, the patients were placed on highly active antiretroviral therapy (HAART) and rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (RCHOP) regimen. Besides, antibiotics, nutritional support and immune-modulating drugs were also administered, rationally. Postoperatively, the height of the anterior edge of the injured vertebrae, Visual Analogue Scale (VAS) and Oswestry Disability Index (ODI) values were evaluated. Patients were also monitored for any complications related to the operation., Results: The average CD4+T cell count for the patients was 164 (range 114 ~247 / ul), while the viral load was 26,269 (range 5,765 ~82,321 copies/ul). All patients received nutritional and immune support and registered significant improvements in the levels of ALB and Hb (P<0.05). In all cases, the operation was uneventful with neither cement leakage nor toxic reactions observed. Similarly, no opportunistic infections, other complications or deaths were reported. The height of the anterior vertebral body and the ODI score of the injured vertebrae were significantly improved immediately after surgery (P<0.05). Compared to the preoperative VAS (7.71±1.11), postoperative values were significantly reduced immediately after surgery (3.85±0.90) and at 2 weeks, 1 month and 6 months post-surgery: 2.71±0.76, 3.29±1.11, and 4.00±0.82, respectively (P<0.01)., Conclusion: Supported with appropriate perioperative treatment measures, PKP is safe and effective in the treatment of pathological vertebral compression fracture due to extra-nodal lymphoma in HIV-positive patients., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
- Published
- 2020
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39. Preparation and Preliminary Evaluation of 68Ga-Acridine: An Attempt to Study the Potential of Radiolabeled DNA Intercalator as a PET Radiotracer for Tumor Imaging.
- Author
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Ghosh S, Das T, Suman SK, Sarma HD, and Dash A
- Subjects
- Acridines chemical synthesis, Acridines pharmacokinetics, Animals, Cell Line, Tumor, Gallium Radioisotopes, Humans, Intercalating Agents chemical synthesis, Intercalating Agents pharmacokinetics, Mice, Molecular Structure, Neoplasms, Experimental diagnostic imaging, Radiopharmaceuticals chemical synthesis, Radiopharmaceuticals pharmacokinetics, Tissue Distribution, Acridines chemistry, Burkitt Lymphoma diagnostic imaging, Fibrosarcoma diagnostic imaging, Intercalating Agents chemistry, Positron-Emission Tomography, Radiopharmaceuticals chemistry
- Abstract
Introduction: Acridine is a well-known DNA intercalator and thereby gets easily inserted within DNA. As uncontrolled rapid cell division is one of the primary characteristics of the tumors, it is expected that acridine or its suitable derivatives will have preferential accumulation in the tumorous lesions. Therefore, an attempt was made to radiolabel an acridine derivative with 68Ga and study the potential of the 68Ga-acridine complex as a PET agent for tumor imaging., Methods: 9-aminoacridine was coupled with p-NCS-benzyl-DOTA to render it suitable for labeling with 68Ga. The purified acridine-DOTA conjugate was radiolabeled with 68Ga, eluted from a 68Ge/68Ga radionuclide generator. Various radiolabeling parameters were optimized and the stability of the radiolabeled preparation was studied. The biological behavior of the 68Ga-acridine complex was studied both in vitro and in vivo using Raji cell line and fibrosarcoma tumor bearing Swiss mice, respectively., Results: 68Ga-acridine complex was obtained with ~100% radiochemical purity under the optimized reaction conditions involving incubation of 2mg/mL of ligand at 100°C for 30 minutes. The complex maintained a radiochemical purity of >95% in normal saline and >65% in human blood serum at 3h post-incubation. In vitro cellular study showed (3.2±0.1)% uptake of the radiotracer in the Raji cells. Biodistribution study revealed significant tumor accumulation [(11.41±0.41)% injected activity in per gram] of the radiotracer within 1h postadministration along with uptake in other non-target organs such as, blood, liver, GIT kidney etc. Conclusion: The present study indicates the potential of 68Ga-acridine as a PET agent for imaging of tumorous lesions. However, further detailed evaluation of the agent is warranted to explore its actual potential., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
- Published
- 2020
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40. Diagnostic yield and safety of ultrasound-guided bowel mass biopsies in children.
- Author
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Minhas K, Roebuck DJ, Barnacle A, De Coppi P, Sebire N, and Patel PA
- Subjects
- Adolescent, Biopsy, Needle methods, Burkitt Lymphoma diagnostic imaging, Child, Child, Preschool, Cohort Studies, Colon diagnostic imaging, Databases, Factual, Female, Hospitals, Pediatric, Humans, Immunohistochemistry, Infant, Lymphoma, B-Cell diagnostic imaging, Male, Retrospective Studies, Risk Assessment, United States, Burkitt Lymphoma pathology, Colon pathology, Image-Guided Biopsy methods, Lymphoma, B-Cell pathology, Patient Safety, Ultrasonography, Interventional methods
- Abstract
Background: Traditionally, ultrasound (US)-guided bowel mass biopsies are avoided in favour of endoscopic or surgical biopsies. However, endoscopy cannot easily reach lesions between the duodenojejunal flexure and the terminal ileum and lesions not involving the mucosa may not be accessible via an endoscopic route., Objective: The aim of this study was to report our technique and to assess the diagnostic accuracy and safety of US-guided biopsy of bowel masses in children., Materials and Methods: We conducted a 14-year retrospective review of US-guided bowel mass biopsies at a single paediatric hospital., Results: Twenty US-guided bowel mass biopsies were performed in 19 patients (median age: 6 years and 6 months, range: 22 months-17 years, median weight: 22 kg, range: 10.2-48.4 kg). For 14 biopsies, there was no other lesion that could potentially be biopsied. A percutaneous coaxial technique was used for 19 biopsies and a transanal non-coaxial biopsy was performed in 1. A median of 9 (range: 2-15) cores of tissue was obtained at each biopsy. The technical success rate and adequacy of diagnostic yield were 100%. The most common diagnosis was lymphoma, which occurred in 16 biopsies. Three biopsies contained mucosa. There was one complication out of 20 biopsies (5%, 95% confidence interval 0-15%): a self-limiting, post biopsy pyrexia. Nineteen procedures were accompanied by a bone marrow aspirate and/or trephine within 2 weeks of the bowel biopsy, only one of which was diagnostic., Conclusion: US-guided bowel mass biopsy can be performed safely in children, with a high diagnostic yield and low complication rate.
- Published
- 2019
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41. Burkitt's Lymphoma Involving Multiple Hormone-Producing Organs on FDG PET/CT.
- Author
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Wen Z and Zhuang H
- Subjects
- Humans, Male, Young Adult, Burkitt Lymphoma diagnostic imaging, Burkitt Lymphoma metabolism, Fluorodeoxyglucose F18, Hormones biosynthesis, Positron Emission Tomography Computed Tomography
- Abstract
Lymphoma involving many different organs can be occasionally observed. However, lymphoma involvement of multiple hormone-producing organs is rare. In this report, we described our FDG PET/CT findings in a 21-year-old man whose Burkitt's lymphoma involved not only lymph nodes, the spleen, the brain, and the bones, but also 4 organs in the endocrine system, including the thyroid, right adrenal, the pancreas, and the right testicle.
- Published
- 2019
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42. Burkitt's lymphoma nodular cystic hepatosplenic, in HIV patient. Case report
- Author
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De la Cruz-Hernández I, Mejía-Martínez JC, Soberanes-Cerino CJ, and Mejía-Picasso CA
- Subjects
- Burkitt Lymphoma diagnostic imaging, Burkitt Lymphoma pathology, HIV Infections, Humans, Liver Neoplasms diagnostic imaging, Liver Neoplasms pathology, Lymphoma, AIDS-Related diagnostic imaging, Lymphoma, AIDS-Related pathology, Male, Splenic Neoplasms diagnostic imaging, Splenic Neoplasms pathology, Young Adult, Burkitt Lymphoma etiology, Liver Neoplasms etiology, Lymphoma, AIDS-Related etiology, Splenic Neoplasms etiology
- Abstract
Background: Patients with human immunodeficiency virus (HIV) are more likely to develop cancer. Malignant lymphomas are the main cancer group seen in these patients. Diffuse large B-cell lymphoma including central nervous system lymphoma and Burkitt's lymphoma account for 90% of HIV-related non-Hodgkin's lymphomas., Clinical Case: A 22-year-old man with fever up to 39 ° C, malaise, excessive tiredness and night sweats, loss of 8 kg of weight, abdominal pain in the right hypochondrium, all 5 months before hospitalization. Hemoglobin: 9.5 g/dL, leukocytes 5.13 x 103/mm3, platelets 124 000 cel/mm3; albumin 2.9 g/dL, alanine aminotransferase 28 IU/L, aspartate aminotransferase 105 IU/L; HIV reactive, beta 2 microglobulin: 20 000 ng/mL. Viral load for HIV 100 034 cp/mL, CD4: 76 cel/mcL (5%). It was performed abdominal ultrasound and denoted cysts in the liver and spleen. Abdominal-pelvic computed tomography with hepatosplenomegaly, retroperitoneal and inguinal adenopathies and free fluid in abdominal cavity. Splenectomy was performed and Burkitt's lymphoma was reported in the histopathological study., Conclusion: HIV predisposes patients to any type of cancer. Intra-abdominal findings should be a warning of lymphoma suspicious and may occur from infiltration of the small intestine, solid organ and soft tissues.
- Published
- 2019
43. Prognostic role of ΔMTV and ΔTLG in Burkitt lymphoma.
- Author
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Albano D, Re A, Tucci A, Giubbini R, and Bertagna F
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Burkitt Lymphoma diagnostic imaging, Burkitt Lymphoma pathology, Female, Humans, Image Interpretation, Computer-Assisted, Male, Middle Aged, Positron Emission Tomography Computed Tomography, Prognosis, Retrospective Studies, Young Adult, Burkitt Lymphoma diagnosis, Burkitt Lymphoma metabolism, Glycolysis, Tumor Burden
- Abstract
Objective: Burkitt's lymphoma (BL) is an aggressive lymphoma sub-type with high 18F-FDG avidity, but no well established evidence of PET/CT's role in treatment evaluation or prognosis is currently available. The prognostic role of visual analysis and Deauville criteria for BL have already been demonstrated, while the potential usefulness of semi-quantitative PET/CT features remains unclear, especially the value of the rate of reduction in metabolic tumor volume (MTV) and total lesion glycolysis (TLG). The aim of this retrospective study was to investigate whether ΔMTV and ΔTLG can predict treatment response at the end of therapy and prognosis in BL., Methods: We retrospectively included 61 patients (mean age 61; 40 male, 21 female) who underwent baseline, interim and end-of-treatment 18F-FDG PET/CT. The PET/CT images were analyzed visually and semi-quantitatively by measuring total metabolic tumor volume (MTV) and total lesion glycolysis (TLG) for every scan. Then we calculated volume changes based on the percentage of MTV and TLG reduction between the baseline and interim PET (ΔMTVi and ΔTLGi) and between baseline and end-of-treatment PET/CT (ΔMTVeot and ΔTLGeot) and correlated them with clinical response and progression-free survival (PFS) and overall survival (OS). Survival curves were plotted according to the Kaplan-Meier method., Results: Forty patients had a complete response and 21 patients a partial response on interim 18F-FDG PET/CT. At end of treatment, 45 had a complete response, 11 partial response and 5 disease progression. At a median follow-up of 43 months, relapse/progression occurred in 18 patients and death in 11. ΔMTV and ΔTLG values were significantly higher in patients with complete response compared to no complete response. ΔMTVeot and ΔTLGeot were demonstrated to be independent prognostic factors for both PFS and OS, while ΔMTVi and ΔTLGi were not related to survival., Conclusions: Metabolic tumor features (ΔMTV and ΔTLG) were significantly correlated with response to treatment and long-term outcome in BL.
- Published
- 2019
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44. Comprehensive approach to diagnosis and treatment of newly diagnosed primary CNS lymphoma.
- Author
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Grommes C, Rubenstein JL, DeAngelis LM, Ferreri AJM, and Batchelor TT
- Subjects
- Age Factors, Antineoplastic Agents, Alkylating administration & dosage, Burkitt Lymphoma diagnostic imaging, Burkitt Lymphoma epidemiology, Burkitt Lymphoma pathology, Burkitt Lymphoma therapy, Central Nervous System Neoplasms diagnostic imaging, Central Nervous System Neoplasms epidemiology, Central Nervous System Neoplasms pathology, Chemoradiotherapy, Cranial Irradiation adverse effects, Cytoreduction Surgical Procedures, Humans, Immunocompromised Host, Lymphoma, Large B-Cell, Diffuse diagnostic imaging, Lymphoma, Large B-Cell, Diffuse epidemiology, Lymphoma, Large B-Cell, Diffuse pathology, Lymphoma, T-Cell diagnostic imaging, Lymphoma, T-Cell epidemiology, Lymphoma, T-Cell pathology, Lymphoma, T-Cell therapy, Methotrexate administration & dosage, Neoplasm Staging, Neurosurgical Procedures, Prognosis, Rituximab administration & dosage, Survival Rate, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Central Nervous System Neoplasms therapy, Cranial Irradiation methods, Lymphoma, Large B-Cell, Diffuse therapy
- Abstract
Primary central nervous system lymphoma (PCNSL) is a rare form of non-Hodgkin lymphoma that affects the brain parenchyma, spinal cord, eyes, and cerebrospinal fluid without evidence of systemic, non-CNS involvement. PCNSL is uncommon and only a few randomized trials have been completed in the first-line setting. Over the past decades, the prognosis of PCNSL has improved, mainly due to the introduction and widespread use of high-dose methotrexate, which is now the backbone of all first-line treatment polychemotherapy regimens. Despite this progress, durable remission is recorded in only 50% of patients, and therapy can be associated with significant late neurotoxicity. Here, we overview the epidemiology, clinical presentation, staging evaluation, prognosis, and current up-to-date treatment of immunocompetent PCNSL patients., (© The Author(s) 2018. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2019
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45. Prognostic role of baseline 18F-FDG PET/CT metabolic parameters in Burkitt lymphoma.
- Author
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Albano D, Bosio G, Pagani C, Re A, Tucci A, Giubbini R, and Bertagna F
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Burkitt Lymphoma pathology, Female, Fluorodeoxyglucose F18, Glycolysis, Humans, Male, Middle Aged, Predictive Value of Tests, Prognosis, Radiopharmaceuticals, Burkitt Lymphoma diagnostic imaging, Positron Emission Tomography Computed Tomography standards
- Abstract
Purpose: Burkitt's lymphoma (BL) is an aggressive lymphoma subtype with high 18F-FDG avidity at 18F-FDG-PET/CT, but no validated criteria for PET/CT in treatment evaluation or prediction of outcome in BL are available. The aim of our study was to investigate whether the metabolic baseline PET/CT parameters can predict treatment response and prognosis in BL., Materials and Methods: We retrospectively enrolled 65 patients who underwent baseline 18F-FDG-PET/CT, interim and end of treatment PET/CT. The PET images were analyzed visually and semi-quantitatively by measuring the maximum standardized uptake value body weight (SUVbw), the maximum standardized uptake value lean body mass (SUVlbm), the maximum standardized uptake value body surface area (SUVbsa), lesion to liver SUVmax ratio (L-L SUV R), lesion to blood-pool SUVmax ratio (L-BP SUV R), total metabolic tumor volume (tMTV) and total lesion glycolysis (TLG). Survival curves were plotted according to the Kaplan-Meier method., Results: At a median follow-up of 40 months, the median PFS and OS were 34 and 39 months. MTV and TLG were significantly higher in patients with partial response compared to complete response group at end of treatment, while no significant differences were found at interim. Other metabolic PET/CT parameters were not related to treatment response. MTV and TLG were demonstrated to be independent prognostic factors for both PFS and OS; instead SUVbw, SUVlbm, SUVbsa, L-L SUV R and L-BP SUV R were not related to outcome survival., Conclusions: Metabolic tumour features (MTV and TLG) were significantly correlated with response to treatment and long-term outcome.
- Published
- 2019
- Full Text
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46. Skin involvement in Burkitt's lymphoma.
- Author
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Thakkar D, Lipi L, Misra R, and Yadav SP
- Subjects
- Burkitt Lymphoma diagnostic imaging, Burkitt Lymphoma pathology, Child, Cyclophosphamide administration & dosage, Doxorubicin administration & dosage, Humans, Male, Methotrexate administration & dosage, Prednisone administration & dosage, Skin Neoplasms diagnostic imaging, Skin Neoplasms pathology, Vincristine administration & dosage, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Burkitt Lymphoma drug therapy, Skin Neoplasms drug therapy
- Abstract
Skin involvement in Burkitt's lymphoma (BL) is rare, more so in the pediatric age group. There are very few cases of BL involving skin either at presentation or relapse reported in literature. We report a case of a 9-years old boy with stage 4 Burkitt's lymphoma with skin involvement who tested negative for human immune-deficiency virus., (Copyright © 2018 King Faisal Specialist Hospital & Research Centre. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2018
- Full Text
- View/download PDF
47. Usefulness of core needle biopsy for the diagnosis of thyroid Burkitt's lymphoma: a case report and review of the literature.
- Author
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Bernardi S, Michelli A, Bonazza D, Calabrò V, Zanconati F, Pozzato G, and Fabris B
- Subjects
- Antineoplastic Combined Chemotherapy Protocols administration & dosage, Biopsy, Large-Core Needle methods, Burkitt Lymphoma diagnostic imaging, Female, Humans, Middle Aged, Thyroid Gland diagnostic imaging, Thyroid Gland drug effects, Thyroid Neoplasms diagnostic imaging, Thyroid Neoplasms drug therapy, Thyroid Nodule diagnostic imaging, Thyroid Nodule drug therapy, Burkitt Lymphoma pathology, Thyroid Gland pathology, Thyroid Neoplasms pathology
- Abstract
Background: Thyroid lymphomas are an exceptional finding in patients with thyroid nodules. Burkitt's lymphoma is one of the rarest and most aggressive forms of thyroid lymphomas, and its prognosis depends on the earliness of medical treatment. Given the rarity of this disease, making a prompt diagnosis can be challenging. For instance, fine-needle aspiration (FNA) cytology, which is the first-line diagnostic test that is performed in patients with thyroid nodules, is often not diagnostic in cases of thyroid lymphomas, with subsequent delay of the start of therapy., Case Presentation: Here we report the case of a 52-year-old woman presenting with a rapidly enlarging thyroid mass. Thyroid ultrasonography demonstrated a solid hypoechoic nodule. FNA cytology was only suggestive of a lymphoproliferative disorder and did not provide a definitive diagnosis. It is core needle biopsy (CNB) that helped us to overcome the limitations of routine FNA cytology, showing the presence of thyroid Burkitt's lymphoma. Subsequent staging demonstrated bone marrow involvement. The early start of an intensive multi-agent chemotherapy resulted in complete disease remission. At 60 months after the diagnosis, the patient is alive and has not had any recurrence., Conclusions: Clinicians should be aware that thyroid Burkitt's lymphoma is an aggressive disease that needs to be treated with multi-agent chemotherapy as soon as possible. To diagnose it promptly, they should consider to order/perform a CNB in any patient with a rapidly enlarging thyroid mass that is suspicious for lymphoma.
- Published
- 2018
- Full Text
- View/download PDF
48. Ethmoidal and extranodal Burkitt lymphoma in a child with bilateral kidney Burkitt lymphoma lesions incidentally detected by 18 F-FDG PET/CT.
- Author
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Bonacina M, Bertoli M, Albano D, Bertagna F, Laffranchi F, and Giubbini R
- Subjects
- Burkitt Lymphoma pathology, Child, Preschool, Humans, Kidney Neoplasms pathology, Male, Burkitt Lymphoma diagnostic imaging, Ethmoid Sinus diagnostic imaging, Fluorodeoxyglucose F18, Kidney Neoplasms diagnostic imaging, Paranasal Sinus Neoplasms diagnostic imaging, Positron Emission Tomography Computed Tomography, Radiopharmaceuticals
- Published
- 2018
- Full Text
- View/download PDF
49. Burkitt lymphoma of the stomach in an immunocompetent patient.
- Author
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Dorra T, Norsaf B, Meriam S, Asma O, and Ehsen BB
- Subjects
- Abdominal Pain diagnosis, Abdominal Pain etiology, Adult, Biopsy, Needle, Burkitt Lymphoma diagnostic imaging, Burkitt Lymphoma drug therapy, Follow-Up Studies, Gastroscopy methods, Humans, Immunohistochemistry, Male, Stomach Neoplasms diagnostic imaging, Stomach Neoplasms drug therapy, Tomography, X-Ray Computed methods, Treatment Outcome, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Burkitt Lymphoma pathology, Immunocompetence, Stomach Neoplasms pathology
- Published
- 2018
- Full Text
- View/download PDF
50. Hepatobiliary and Pancreatic: Burkitt lymphoma mimicking IgG4-related disease.
- Author
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Azuma S, Kurita A, and Yazumi S
- Subjects
- Burkitt Lymphoma genetics, Diagnosis, Differential, Humans, Kidney diagnostic imaging, Macrophages pathology, Male, Middle Aged, Portal Vein diagnostic imaging, Proto-Oncogene Proteins c-myc genetics, Salivary Glands pathology, Burkitt Lymphoma diagnostic imaging, Burkitt Lymphoma pathology, Endosonography, Immunoglobulin G4-Related Disease, Pancreas diagnostic imaging, Pancreas pathology, Tomography, X-Ray Computed
- Published
- 2018
- Full Text
- View/download PDF
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