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To determine if milk composition, milk yield, live weight, live weight change, breed and heterosis are associated with reproductive performance in dairy cows from two dairy farms under New Zealand grazing conditions. Milk composition was determined in herd tests from 205 Holstein-Friesian (F), 77 Jersey (J) and 351 F × J crossbred cows from two Massey University dairy herds in the 2016 and 2017 production seasons. Mating occurred from October to December in each production season. The start of breeding to first service (SBFS), start of breeding to conception (SBCO), submission rate at 21 days (SR21), pregnancy rate at 21 (PR21) and 42 days (PR42) were calculated for each cow. These traits were analysed using mixed linear models that included fixed effects for herd, production season, regression coefficients of deviation from median calving date, lactation number, proportion of F, F × J heterosis, energy-corrected milk yield (ECMY), percentages of fat, protein and lactose, milk urea nitrogen (MUN), live weight and change in live weight, with random effects for cow and residual error. The variables with binomial distribution were analysed using logistic regression. Deviation from the herd's median calving date had a significant effect (p < 0.05) on all reproductive traits. Proportion of F was significant (p = 0.022) on PR21, and F × J heterosis effects were significant on PR21 (p = 0.049) and PR42 (p = 0.046). F cows had 17.8% higher PR21 than J cows, and F × J cows had higher reproductive performance than the mean of the two purebreeds. ECMY was negatively associated with SBFS (p = 0.001) and SBCO (p = 0.001) and positively associated with PR21 (p = 0.002) and PR42 (p = 0.001). Protein percentage was positively associated (p < 0.05) with PR21 and PR42, whereas lactose percentage was negatively associated (p < 0.05) with PR21 and PR42. Cows gaining live weight were more likely to become pregnant within 21 days of the start of breeding (p = 0.020). Milk urea nitrogen was negatively associated (p = 0.042) with SR21. This study confirms that breed, heterosis, ECMY, protein and lactose percentages, live weight change and calving date are associated with the reproductive performance of grazing cows. Results from this study contrast with the historical antagonism between milk production and reproductive performance in dairy cattle, demonstrating that well managed cows can achieve high levels of production and good reproductive performance. MUN was not associated with reproductive performance traits, except with SR21. [ABSTRACT FROM AUTHOR]

Objective: Racial biases exist in almost every aspect of the criminal legal system, resulting in disparities across all stages of legal procedures-before, during, and after a legal procedure. Building on expected utility theory, we propose an expected utility framework to organize and quantify racial disparities in legal procedures., Hypotheses: Corresponding to the parameteres involved in estimating expected utility, we hypothesized that racial biases would occur at different stages of legal procedures., Method: Using police interrogation procedures as an example, we obtained estimates from previous literature and demonstrated that racial disparities exist at each stage of legal procedures. We then used these estimates to compute and visualize expected utilities, which quantify the average long-term outcomes of interrogations for minority versus nonminority suspects., Results: Based on this hypothetical example, the expected utility analysis suggests that biases at various stages of interrogations could potentially lead to substantial disparities in legal outcomes between racial groups. In particular, the example shows that interrogations might yield notably worse outcomes for minority suspects than nonminority suspects because of cumulative biases that occur before, during, and after this legal procedure., Conclusions: The proposed expected utility approach not only offers a valuable tool for accounting the joint impacts of multiple stages of legal procedures to quantify racial disparities but also carries important implications for how the criminal legal system could reduce such disparities. That is, the criminal legal system must seek to reduce racial biases across all stages of legal procedures rather than focusing on just one aspect. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Study Objective: Investigate a low-cost, nasopharyngeal apnoeic oxygenation technique, establish its efficacy, and compare it to preoxygenation only in an obese population. The study's hypothesis was that nasopharyngeal apnoeic oxygenation at 18 l.min -1 would significantly prolong safe apnoea time compared to preoxygenation alone., Design: Randomised controlled study., Setting: Theatre complex of a resource constrained hospital., Patients: 30 adult, obese (BMI ≥ 35 kg.m -2 ) patients presenting for elective surgery. Patients with limiting cardio-respiratory disease, suspected difficult airway, risk of aspiration, and that were pregnant, were excluded. Patients were allocated by block randomisation in a 1:2 ratio to a preoxygenation-only (No-AO) and an intervention group (NPA-O 2 )., Interventions: All patients were preoxygenated to an Et-O2 > 80%, followed by a standardised induction. The intervention group received oxygen at 18 l.min -1 via the nasopharyngeal catheter intervention. The desaturation process was documented until an SpO 2 of 92% or 600 s was reached., Measurements: Baseline demographic and clinical characteristics were collected. The primary outcome was safe apnoea time, defined as the time taken to desaturate to an SpO 2 of 92%. Secondary outcomes were rate of carbon dioxide accumulation and factors affecting the risk of desaturation., Main Results: The study was conducted in a morbidly obese population (NoAO = 41,1 kg.m -2 ; NPA-O 2  = 42,5 kg.m -2 ). The risk of desaturation was signifantly lower in the intervention group (Hazzard Ratio = 0,072, 95% CI[0,019-0,283]) (Log-Rank test, p < 0.001). The median safe apnoea time was significantly longer in the intervention group (NoAO = 262 s [IQR 190-316]; NPA-O 2  = 600 s [IQR 600-600]) (Mann-Whitney-U test, p < 0.001). The mean rate of CO 2 accumalation was significantly slower in the intervention group (NoAO = 0,47 ± 0,14 kPa.min -1 ; NPA-O 2  = 0,3 ± 0,09 kPa.min -1 ) (t-test, p = 0.003). There were no statistically significant risk factors associated with an increased risk of desaturation found., Conclusions: Nasopharyngeal apnoeic oxygenation at 18 l/min prolongs safe apnoea time, compared to preoxygenation alone, and reduces the risk of desaturation in morbidly obese patients., Clinical Trial Registration: PACTR202202665252087; WC/202004/007., Competing Interests: Declaration of Competing Interest There were no conflict of interest of either authors in the production of this wok. The research was conducted for completion of Degree purposes. There was no funding, grants, stock ownership or patent applications made. There are no academic disclosures to mention., (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)

There is a growing interest in the use of yeast ( Saccharomyces cerevisiae ) culture (YC) for the enhancement of growth performance and general animal health. Grain-based pelleted total mixed rations (TMR) are emerging in intensive sheep farming systems, but it is uncertain if the process of pelleting results in YC becoming ineffective. This study aimed to examine the effects of YC supplemented to pelleted TMR at two proportions of corn in the diet on animal performance, feed digestion, blood parameters, rumen fermentation, and microbial community in fattening lambs. A 2 × 2 factorial design was adopted with two experimental factors and two levels in each factor, resulting in four treatments: (1) low proportion of corn in the diet (LC; 350 g corn/kg diet) without YC, (2) LC with YC (5 g/kg diet), (3) high proportion of corn in the diet (HC; 600 g corn/kg diet) without YC, and (4) HC with YC. Fifty-six 3-month-old male F2 hybrids of thin-tailed sheep and Northeast fine-wool sheep with a liveweight of 19.9 ± 2.7 kg were randomly assigned to the four treatment groups with an equal number of animals in each group. The results showed that live yeast cells could not survive during pelleting, and thus, any biological effects of the YC were the result of feeding dead yeast and the metabolites of yeast fermentation rather than live yeast cells. The supplementation of YC resulted in 31.1 g/day more average daily gain regardless of the proportion of corn in the diet with unchanged feed intake during the 56-day growth measurement period. The digestibility of neutral detergent fibre and acid detergent fibre was increased, but the digestibility of dry matter, organic matter, and crude protein was not affected by YC. The supplementation of YC altered the rumen bacterial population and species, but the most abundant phyla Bacteroidetes, Firmicutes , and Proteobacteria remained unchanged. This study indicates that YC products can be supplemented to pelleted TMR for improved lamb growth performance, although live yeast cells are inactive after pelleting. The improved performance could be attributed to improved fibre digestibility., Competing Interests: PY and WY were employed by Portal Agri-Industries Co., Ltd. HW and KK were employed by Angel Yeast Co., Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The funders of the study were not involved in the study design, the collection, analysis, and interpretation of data, the writing of this article or the decision to submit it for publication., (Copyright © 2021 Song, Wu, You, Wang, Burke, Kang, Yu, Wang, Li, He, Huo, Li, Tian, Li, Li, Wang and Sun.)

The objective of the present study was to investigate the phenotypic inter- and intra-relationships within and among alternative feed efficiency metrics across different stages of lactation and parities; the expected effect of genetic selection for feed efficiency on the resulting phenotypic lactation profiles was also quantified. A total of 8,199 net energy intake (NE I ) test-day records from 2,505 lactations on 1,290 cows were used. Derived efficiency traits were either ratio based or residual based; the latter were derived from least squares regression models. Residual energy intake (REI) was defined as NE I minus predicted energy requirements based on lactation performance; residual energy production (REP) was defined as net energy for lactation minus predicted energy requirements based on lactation performance. Energy conversion efficiency was defined as net energy for lactation divided by NE I . Pearson phenotypic correlations among traits were computed across lactation stages and parities, and the significance of the differences was determined using the Fisher r-to-z transformation. Sources of variation in the feed efficiency metrics were investigated using linear mixed models, which included the fixed effects of contemporary group, breed, parity, stage of lactation, and the 2-way interaction of parity by stage of lactation. With the exception of REI, parity was associated with all efficiency and production traits. Stage of lactation, as well as the 2-way interaction of parity by stage of lactation, were associated with all efficiency and production traits. Phenotypic correlations among the efficiency and production traits differed not only by stage of lactation but also by parity. For example, the strong phenotypic correlation between REI and energy balance (EB; 0.89) for cows in parity 3 or greater and early lactation was weaker for parity 1 cows at the same lactation stage (0.81), suggesting primiparous cows use the ingested energy for both milk production and growth. Nonetheless, these strong phenotypic correlations between REI and EB suggested negative REI animals (i.e., more efficient) are also in more negative EB. These correlations were further supported when assessing the effect on phenotypic performance of animals genetically divergent for feed intake and efficiency based on parental average. Animals genetically selected to have lower REI resulted in cows who consumed less NE I but were also in negative EB throughout the entire lactation. Nonetheless, such repercussions of negative EB do not imply that selection for negative REI (as defined here) should not be practiced, but instead should be undertaken within the framework of a balanced breeding objective, which includes traits such as reproduction and health., (Copyright © 2018 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.)

The objective of the present study was to estimate genetic parameters across lactation for measures of energy balance (EB) and a range of feed efficiency variables as well as to quantify the genetic inter-relationships between them. Net energy intake (NEI) from pasture and concentrate intake was estimated up to 8 times per lactation for 2,481 lactations from 1,274 Holstein-Friesian cows. A total of 8,134 individual feed intake measurements were used. Efficiency traits were either ratio based or residual based; the latter were derived from least squares regression models. Residual energy intake (REI) was defined as NEI minus predicted energy requirements [e.g., net energy of lactation (NE L ), maintenance, and body tissue anabolism] or supplied from body tissue mobilization; residual energy production was defined as the difference between actual NE L and predicted NE L based on NEI, maintenance, and body tissue anabolism/catabolism. Energy conversion efficiency was defined as NE L divided by NEI. Random regression animal models were used to estimate residual, additive genetic, and permanent environmental (co)variances across lactation. Heritability across lactation stages varied from 0.03 to 0.36 for all efficiency traits. Within-trait genetic correlations tended to weaken as the interval between lactation stages compared lengthened for EB, REI, residual energy production, and NEI. Analysis of eigenvalues and associated eigenfunctions for EB and the efficiency traits indicate the ability to genetically alter the profile of these lactation curves to potentially improve dairy cow efficiency differently at different stages of lactation. Residual energy intake and EB were moderately to strongly genetically correlated with each other across lactation (genetic correlations ranged from 0.45 to 0.90), indicating that selection for lower REI alone (i.e., deemed efficient cows) would favor cows with a compromised energy status; nevertheless, selection for REI within a holistic breeding goal could be used to overcome such antagonisms. The smallest (8.90% of genetic variance) and middle (11.22% of genetic variance) eigenfunctions for REI changed sign during lactation, indicating the potential to alter the shape of the REI lactation profile. Results from the present study suggest exploitable genetic variation exists for a range of efficiency traits, and the magnitude of this variation is sufficiently large to justify consideration of the feed efficiency complex in future dairy breeding goals. Moreover, it is possible to alter the trajectories of the efficiency traits to suit a particular breeding objective, although this relies on very precise across-parity genetic parameter estimates, including genetic correlations with health and fertility traits (as well as other traits)., (Copyright © 2017 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.)

Eruptive forest insects are highly influential agents of change in forest ecosystems, and their effects have increased with recent climate change. State-dependent life histories contribute significantly to the population dynamics of eruptive forest insect herbivores; however, the proximate mechanisms by which these species shift between states is poorly understood. Laboratory bioassays were conducted using the mountain pine beetle (Dendroctonus ponderosae) to determine the effect of maternal host selection on offspring host preferences, as they apply to population state-dependent behaviors. Female mountain pine beetles exhibited state-dependent preference for artificial host material amended with monoterpenes in the absence of other cues, such that individuals reared in high-density epidemic-state simulations rejected low monoterpene conditions, while low-density endemic-state beetles accepted low monoterpene conditions. State-specific behavior in offspring was dependent on rearing conditions, as a function of maternal host selection, and these effects were observed within one generation. Density-dependent host selection behaviors exhibited by female mountain pine beetle offspring is reinforced by context-dependent maternal effects arising from parental host selection, and in situ exposure to conspecifics. These results demonstrate potential proximate mechanisms that control population dynamics in eruptive forest insects, and will allow for more accurate predictions of continued impact and spread of these species.

International interest in feed efficiency, and in particular energy intake and residual energy intake (REI), is intensifying due to a greater global demand for animal-derived protein and energy sources. Feed efficiency is a trait of economic importance, and yet is overlooked in national dairy cow breeding goals. This is due primarily to a lack of accurate data on commercial animals, but also a lack of clarity on the most appropriate definition of the feed intake and utilization complex. The objective of the present study was to derive alternative definitions of energetic efficiency in grazing lactating dairy cows and to quantify the inter-relationships among these alternative definitions. Net energy intake (NEI) from pasture and concentrate intake was estimated up to 8 times per lactation for 2,693 lactations from 1,412 Holstein-Friesian cows. Energy values of feed were based on the French Net Energy system where 1 UFL is the net energy requirements for lactation equivalent of 1kg of air-dry barley. A total of 8,183 individual feed intake measurements were available. Energy balance was defined as the difference between NEI and energy expenditure. Efficiency traits were either ratio-based or residual-based; the latter were derived from least squares regression models. Residual energy intake was defined as NEI minus predicted energy to fulfill the requirements for the various energy sinks. The energy sinks (e.g., NEL, metabolic live weight) and additional contributors to energy kinetics (e.g., live weight loss) combined, explained 59% of the variation in NEI, implying that REI represented 41% of the variance in total NEI. The most efficient 10% of test-day records, as defined by REI (n=709), on average were associated with a 7.59 UFL/d less NEI (average NEI of the entire population was 16.23 UFL/d) than the least efficient 10% of test-day records based on REI (n=709). Additionally, the most efficient 10% of test-day records, as defined by REI, were associated with superior energy conversion efficiency (ECE, i.e., NEL divided by NEI; ECE=0.55) compared with the least efficient 10% of test-day records (ECE=0.33). Moreover, REI was positively correlated with energy balance, implying that more negative REI animals (i.e., deemed more efficient) are expected to be, on average, in greater negative energy balance. Many of the correlations among the 14 defined efficiency traits differed from unity, implying that each trait is measuring a different aspect of efficiency., (Copyright © 2016 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.)

Objective: We previously reported that a rationally designed biomimetic self-assembling peptide, P₁₁-4, nucleated hydroxyapatite de novo and was apparently capable of in situ enamel regeneration following infiltration into caries-like lesions. Our present aim was to determine the safety and potential clinical efficacy of a single application of P₁₁-4 on early enamel lesions., Materials and Methods: Fifteen healthy adults with Class V 'white spot' lesions received a single application of P₁₁-4. Adverse events and lesion appearances were recorded over 180 days., Results: Patients treated with P₁₁-4 experienced a total of 11 adverse events during the study, of which two were possibly related to the protocol. Efficacy evaluation suggested that treatment with P₁₁-4 significantly decreased lesion size (p = 0.02) after 30 days and shifted the apparent progression of the lesions from 'arrested/progressing' to 'remineralising' (p <0.001). A highly significant improvement in the global impression of change was recorded at day 30 compared with baseline (p <0.001)., Conclusions: The results suggest that treatment of early caries lesions with P₁₁-4 is safe, and that a single application is associated with significant enamel regeneration, presumably by promoting mineral deposition within the subsurface tissue.

Background: In the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST), the composite primary endpoint of stroke, myocardial infarction, or death during the periprocedural period or ipsilateral stroke thereafter did not differ between carotid artery stenting and carotid endarterectomy for symptomatic or asymptomatic carotid stenosis. A secondary aim of this randomised trial was to compare the composite endpoint of restenosis or occlusion., Methods: Patients with stenosis of the carotid artery who were asymptomatic or had had a transient ischaemic attack, amaurosis fugax, or a minor stroke were eligible for CREST and were enrolled at 117 clinical centres in the USA and Canada between Dec 21, 2000, and July 18, 2008. In this secondary analysis, the main endpoint was a composite of restenosis or occlusion at 2 years. Restenosis and occlusion were assessed by duplex ultrasonography at 1, 6, 12, 24, and 48 months and were defined as a reduction in diameter of the target artery of at least 70%, diagnosed by a peak systolic velocity of at least 3·0 m/s. Studies were done in CREST-certified laboratories and interpreted at the Ultrasound Core Laboratory (University of Washington). The frequency of restenosis was calculated by Kaplan-Meier survival estimates and was compared during a 2-year follow-up period. We used proportional hazards models to assess the association between baseline characteristics and risk of restenosis. Analyses were per protocol. CREST is registered with ClinicalTrials.gov, number NCT00004732., Findings: 2191 patients received their assigned treatment within 30 days of randomisation and had eligible ultrasonography (1086 who had carotid artery stenting, 1105 who had carotid endarterectomy). In 2 years, 58 patients who underwent carotid artery stenting (Kaplan-Meier rate 6·0%) and 62 who had carotid endarterectomy (6·3%) had restenosis or occlusion (hazard ratio [HR] 0·90, 95% CI 0·63-1·29; p=0·58). Female sex (1·79, 1·25-2·56), diabetes (2·31, 1·61-3·31), and dyslipidaemia (2·07, 1·01-4·26) were independent predictors of restenosis or occlusion after the two procedures. Smoking predicted an increased rate of restenosis after carotid endarterectomy (2·26, 1·34-3·77) but not after carotid artery stenting (0·77, 0·41-1·42)., Interpretation: Restenosis and occlusion were infrequent and rates were similar up to 2 years after carotid endarterectomy and carotid artery stenting. Subsets of patients could benefit from early and frequent monitoring after revascularisation., Funding: National Institute of Neurological Disorders and Stroke and Abbott Vascular Solutions., (Copyright © 2012 Elsevier Ltd. All rights reserved.)

Background: Tests were conducted on two insecticides (carbaryl and bifenthrin) for excluding subcortical beetles (Coleoptera: Curculionidae and Cerambycidae) from loblolly pine trees (Pinus taeda L.). Two trap designs (single- and double-pane windows) and two trapping heights (1.5 and 4 m) were also evaluated for maximizing beetle catches., Results: In July 2009, 15 loblolly pine trees were double girdled and were either left unsprayed or sprayed with carbaryl or bifenthrin. A total of 28 473 bark beetles were caught in window traps, including Ips avulsus Eichoff, I. grandicollis (Eichhoff), I. calligraphus (Germar) and Dendroctonus terebrans (Olivier). Both insecticides significantly reduced colonization of the trees by bark and woodboring beetles by 300-400%, with no differences in efficacy observed between the two insecticides. About 59% more I. avulsus were caught in double- than in single-pane window traps, with no differences for any other species. Traps at 4 m caught more I. avulsus and I. grandicollis (290 and 153% respectively), while traps at 1.5 m caught more D. terebrans (215%)., Conclusions: Either bifenthrin or carbaryl can be used to exclude subcortical beetles from loblolly pine trees. Trapping data reflect known vertical partitioning on the bole by these insects. Double-pane traps were slightly more effective than single-pane traps in catching subcortical beetles., (Copyright © 2012 Society of Chemical Industry.)

We report results from an initial small animal study designed to provide information on the biocompatibility of a novel biodegradable composite designed for craniomaxillofacial reconstruction. Rat calvarium was chosen as a clinically analogous model, which allowed comparison between experimental groups (PCL alone, PCL/phosphate glass, or PCL/bioglass implants) and control groups (empty defects or bone grafted defects). All animals recovered well from surgery and no clinical complications were observed. Histological assessment indicated a lack of inflammatory response. The amount of new bone formation at the dural aspect of the implant was statistically significantly higher in the PCL/phosphate glass group than the other experimental groups. This study confirms, in a clinically analogous model, the promise of the novel PCL/phosphate glass composite material. Work is planned toward manufacturing scale up and clinical trials., (Copyright © 2010 Wiley Periodicals, Inc.)

This study evaluated the effect of 4 criteria for determining the end-point of milking on milk yield, milk composition, completeness of milking-out, teat skin condition, somatic cell count (SCC), and the incidence of clinical mastitis (CM) in pasture-based dairy cows milked over 35 wk. The objective was to reduce milking duration without affecting milk production, SCC, or CM. Milking end-point treatments were as follows: cluster removed at a milk flow rate of 0.2 kg/min (ACR200); cluster removed at a milk flow rate of 0.4 kg/min (ACR400); cluster removed at a milk flow rate of 0.2 kg/min or at a maximum cluster attachment time from d 5 of lactation (MaxTEarly); and cluster removed at a milk flow rate of 0.2 kg/min until an average of 63+/-21 d in milk, then cluster removed at a milk flow rate of 0.2 kg/min or a maximum cluster attachment time (MaxTPeak). Maximum cluster attachment times were set at 7.5 min and 5.4 min for morning and afternoon milkings, respectively. Cows (approximately 94/treatment) were assigned to treatment at calving and milked twice daily at intervals of 9 and 15 h. Milking duration was shorter for ACR400, MaxTEarly, and MaxTPeak compared with ACR200. During wk 1 to 15, milk, protein, and lactose yields were less for MaxTEarly than for ACR400 and MaxTPeak, but not different from ACR200. During wk 16 to 35 and over the entire experiment, total milk, fat, protein, and lactose yields did not differ among treatments. Teat condition did not differ among the 4 treatments. Postmilking strip yield in wk 12 was greatest for MaxTEarly and least for ACR200; at wk 27, however, treatment had no effect on the completeness of milking-out. No differences were observed in either teat condition or the proportion of cows with at least 1 case of CM during the 35 wk. Somatic cell count was low across all treatments, but highest for ACR400. Increasing the automatic cluster remover threshold setting from 0.2 to 0.4 kg/min decreased milking duration without affecting milk production, CM, or teat condition. Combining a cluster removal milk flow threshold setting with a maximum cluster attachment time, when applied from either early lactation or from peak lactation, reduced milking duration without affecting milk production, CM, or SCC. Both strategies have potential to improve milking efficiency in dairy herds in which premilking preparation is minimal., (2010 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.)

Background: The testing of the implantable cardioverter-defibrillator (ICD), through the induction of repeated episodes of ventricular fibrillation, has been associated with disturbances in cerebral activity and increased levels of cytoplasmic enzymes. However, the neuropsychological outcomes of cerebral changes and their quality-of-life implications are unknown., Methods and Results: Fifty-two ICD recipients completed standardized validated neuropsychological tests 1 to 3 days before ICD surgery and then 6 weeks, 6 months, and 12 months after surgery. They also completed psychometric tests measuring anxiety, depression, and quality of life. Between 31% and 39% of patients showed a significant neuropsychological impairment from their baseline function 6 weeks, 6 months, and 12 months after surgery. Ten percent of patients had late-onset deficits at 12 months only. Frequent areas of impairment were auditory and visual memory and attention. Neuropsychological impairment was not related to mood or quality of life at follow-up, although anxiety and depression predicted reduced quality of life., Conclusions: ICD implantation is associated with neuropsychological impairment that dissipates for the majority of recipients after 12 months. Short-term memory function and attention are particularly vulnerable to changes in oxygen during ICD testing. Although anxiety and depression are prevalent, there is little evidence for the direct impact of mood on cognition, and deficits appear not to be associated with reduced quality of life. These results provide evidence for longitudinal outcomes of ICD surgery and have implications for patient rehabilitation and adjustment.

Background: The implantable cardioverter defibrillator (ICD) is a device used in the treatment of ventricular arrhythmias and the prevention of sudden cardiac death. However, the ICD has been associated with negative psychological outcomes such as anxiety, depression, panic, and poor quality of life (QoL). Recent studies suggest that the preimplantation psychology of patients, combined with their postimplantation perceptions about their cardiac condition, are greater contributory factors than their medical status to a poor outcome., Method: Our study employed an interview-based qualitative grounded theory methodology to explore whether medical history hetereogeneity and illness beliefs impact on the QoL of 13 ICD patients., Results: Perceived control emerged as the core category related to QoL with three subsystem themes related to control: (1) illness beliefs, attributions, and appraisals; (2) coping resources and strategies; and (3) the social world. Patients at risk for the poorest adaptation were younger (<45), unemployed, and with an acute onset cardiac history. These patients interpreted their illness as severe, utilized emotion-focused coping (e.g., avoidance of situations), and believed themselves to be socially excluded. Adjusted patients used proactive problem-focused coping (e.g., normalizing) and minimized consequences of the device., Conclusions: The data developed a theoretical model of QoL, which identified perceived control, illness beliefs, and coping impacting on adjustment. From our study, we have a wider understanding of the combination psychological issues relevant to ICD patients and are able to treat those at risk with interventions to promote adjustment in the context of a society that values health and well-being.

Reconstruction of craniomaxillofacial defects is a challenge for surgeons and has psychological and functional burdens for patients. Undoubtedly, there is a need for improved biomaterials and techniques for craniomaxillofacial reconstruction. We assessed the potential regeneration of bone using three modifications of a novel composite and explored the validity of a new measurement using microcomputed tomography (micro-CT). We placed three different composite samples in calvarial defects in rats and analysed healing with micro-CT. The results showed that polycaprolactone (PCL) with phosphate glass fibre is promising for non-load bearing applications in the craniomaxillofacial region. Also, the new micro-CT measurement of the temporal characterisation of the mineralisation of bone (TCBM) has the potential to evolve into a reliable predictor of bony healing and its quality.

Background: Large randomized clinical trials have demonstrated differences in the efficacy and safety of glycoprotein (GP) IIb/IIIa inhibitors, but little has been published regarding comparisons of these agents in a "real-world" setting., Purpose: This study evaluated the safety and efficacy of GP IIb/IIIa inhibitors in a large population of patients who underwent percutaneous coronary intervention (PCI) during a 5-year period., Methods: Patients undergoing PCI from 2000 through 2004 were eligible for inclusion if they received any single GP IIb/IIIa inhibitor. Patients with significant comorbidities were included. Patients were excluded if they received more than one GP IIb/IIIa inhibitor or underwent catheterization without PCI. Target activated clotting time was 200-250 seconds., Results: Of 5,055 patients undergoing PCI, 4,321 (85%) received a single GP IIb/IIIa inhibitor (abciximab, 1,178; eptifibatide, 1,698; tirofiban, 1,445). Major bleeding complications were rare, ranging from 1.9-3.1%, and transfusion rates were low, ranging from 0.8-2.1%, with no significant differences among the agents evaluated. No significant differences in 1-year mortality, myocardial infarction, urgent target vessel revascularization or composite endpoint rates were identified among the therapeutic agents., Conclusions: In this large study of PCI patients, GP IIb/IIIa inhibition was associated with a low incidence of major bleeding complications and requirement of transfusion. With appropriate management, GP IIb/IIIa inhibitor use can benefit patients undergoing PCI, with minimal risk of bleeding complications.

Our aim was to evaluate the effects of once-daily milking on the welfare of dairy cows in a pastoral-based farming system. There are concerns that cows milked only once daily may experience discomfort associated with udder distension. We evaluated the behavior, including lying time and postures, grazing patterns, and kicking behavior in the parlor, and measures of udder firmness in cows milked once daily in 2 experiments: 1) at peak lactation, comparing cows milked once (1x) or twice-daily (2x) from the time of calving (n = 4 groups; 1x and 2x treatments); and 2) during the transition from 2x to 1x milking at mid lactation (n = 12 groups; 1x, 2x, and 2x to 1x treatments or TRANS). At peak lactation, cows milked 1x were more likely to lie with their hind legs touching the body than cows milked 2x. There were no differences in udder firmness (1x: 10.0 vs. 2x: 9.9 +/- 0.13 g of force) or kicking (1x: 25 vs. 2x: 24 +/- 7.8%) behavior in the parlor. In the second experiment, milking frequency was reduced from 2x to 1x and this change resulted in an increase in udder firmness (1 x: 9.1, 2x: 9.3, and TRANS: 9.5 +/- 0.14 g of force). Despite these differences in udder firmness, lying time (1x: 10.1, 2x: 9.5, and TRANS: 9.6 +/- 0.38 h/24 h), postures, and concentrations of fecal glucocorticoid metabolites (1x: 10.0, 2x: 10.5, and TRANS: 10.4 +/- 0.49 ng/g of feces in the 3 d after transition) in cows milked 1x or 2x were similar. Although milking frequency did not influence total time spent grazing, the diurnal grazing pattern of cows milked 2x was disrupted by afternoon milking at both peak and mid lactation. Cows milked 2x were able to compensate for this by grazing more after the return to pasture (DIM 153 to 155, 1x: 52 vs. 2x: 66 +/- 6.2 min/90 min of grazing). Cows milked 1x had slightly longer strides than 2x cows at mid lactation (1x: 0.73, 2x: 0.70, and TRANS: 0.70 +/- 0.014 strides/m). In conclusion, under our experimental conditions, we found no overt changes in behavior or physiology to indicate that the welfare of cows milked 1x is impaired.

The production of bone-, dentine- and enamel-like biomaterials for the engineering of mineralized (hard) tissues is a high-priority in regenerative medicine and dentistry. An emerging treatment approach involves the use of short biomimetic peptides that self-assemble to form micrometer-long nanofibrils with well defined surface chemistry and periodicity that display specific arrays of functional groups capable of mineral nucleation. The fibrils also give rise to dynamically stable 3D scaffold gels for the potential control of crystal disposition and growth. Peptides can also be injected in their monomeric fluid state, with subsequent self-assembly and gelation in situ triggered by physiological conditions. In this way, they can infiltrate and self-assemble within irregular or microscopic cavities, for restorative treatment of bone defects, dentinal hypersensitivity or dental decay. Cell adhesion and proliferation is also supported by these scaffolds, offering further advantages for applications in hard tissue engineering. These self-assembling matrices also provide well defined model systems that can contribute greatly to the elucidation of the biological mechanisms of protein-mediated biomineralization.

Objective: The implantable cardioverter defibrillator (ICD) has become the treatment of choice for ventricular arrhythmia (VA; abnormal heart rhythms) and the prevention of sudden cardiac death (SCD). Recent clinical trials have shown the ICD to be superior to anti-arrhythmic medication in reducing mortality; however, research has suggested that ICD recipients experience poor psychosocial adjustment following implantation of the device. This aim of this study was to identify the key psychological characteristics associated with ICD implantation and to establish whether poor psychosocial outcome can be attributed directly to the device and its therapy., Method: Studies which reported valid and reliable measures of psychological functioning in ICD patients and appropriate comparison groups were considered for inclusion in a meta-analytic review. A systematic search of electronic databases and reference lists identified 20 studies which fulfilled the inclusion criteria., Results: There were no significant differences in psychosocial outcome between ICD patients and drug-maintained VA patients or between pre- and post-implant ICD patients. However, ICD patients reported significantly worse psychological functioning and physical functioning than other cardiac controls., Conclusion: These findings suggest that poor psychosocial outcome in ICD patients may occur as a result of variables associated with the underlying VA condition, rather than as a direct response to implantation of the device and its therapy. This holds important implications for the development and implementation of psychological interventions for patients experiencing VA, in preference to ICD-specific programmes.

In this article we try to determine how frequently emergency physicians (EPs) suspected the diagnosis in acute aortic dissection (AD). In this retrospective descriptive study, we identified all patients with the final diagnosis of AD initially evaluated in 1 of 3 emergency departments (EDs) over a 5-year period. Patients were included if AD was not suspected before ED evaluation. Patients undergoing thoracic aorta imaging as the initial ED study were defined as suspected AD. Forty-three patients totaling 44 presentations were identified. EPs suspected AD in 19 of 44 presentations. EPs suspected AD in 12 of 14 (86%) cases of chest and back pain and in 5 of 11 (45%) of chest pain. Thirteen of 39 (33%) painful presentations involved abdominal pain; EPs suspected AD in 1 of 13 (8%). EPs suspected the diagnosis in 43% of acute AD; location of pain was most predictive of a suspected diagnosis.

Spent hens containing hard-shelled eggs were obtained to study the influence of sample collection and sample preparation methodology on the detection of Salmonella in ovaries. Four hundred eighteen birds from 19 flocks were collected, and the carcasses were opened aseptically within 8-12 hours of collection. A sample set containing hard-shelled egg, ovary, and oviduct section were collected from each carcass, and surface contaminants were removed from ovaries with polyoxyethylene ether. Three of 19 flocks (15.8%) and six of 407 ovary samples were positive for Salmonella; two oviduct samples were positive (0.5%). No eggs were Salmonella-positive. Single and multiple serotypes were detected in ovaries. Results indicated that Salmonella recovery rates can be significantly affected by speed in processing samples after collection, by cleanliness of the tissue-collection environment (laboratory vs. slaughter plant), and by removal of surface contaminants.

A study was conducted to determine the frequency of Salmonella enteritidis (SE) and other Salmonella serovars in the cecal contents of spent laying hens at a hen-processing plant in the southeastern United States over a 4 1/2-month period, from October 1990 through February 1991. A total of 1920 pooled cecal samples (three ceca per sample) from 38 flocks representing 23 producers were obtained and tested for the presence of SE and other Salmonella serovars. A total of 359 samples (18.7%) from 37 of the 38 flocks (97.4%) showed characteristic reactions for salmonellae on triple sugar iron agar (TSIA) slants. Twenty-nine of the 359 Salmonella-positive samples (8.1%) were Group D-positive, all of which were found to be SE on further serotyping. The SE-positive samples were from seven of the 38 flocks (18.4%); four flocks originated from the USDA/APHIS-designated Northern Region of the United States, and three were from the Southeastern Region. Serotyping of the 330 TSIA-positive Group-D negative Salmonella revealed 37 different serovars. S. heidelberg, the predominant serovar, was identified in 49.1% of these isolates.

Children ages four to seven judged relative ages of unfamiliar adults from photographs and chose photographs of adults in response to sociometric items. Age discrimination was highly accurate by age six. Children identified older adults as sad, lonely and not busy, but older adults were bypassed on items like "knows a lot" and preferences for teachers. In interviews, most of the children accurately identified older people by relying on physiognomic cues. Most described their grandparents as examples of known older people and expressed positive views of the activities they share. Images of passivity, and of older people engaged in domestic, but not "outside" work were also present. Children's attitudes were found to parallel those held by older adults in recent polls; older children in the sample were more likely to hold stereotypical images. Two-thirds of the children preferred not to grow old. Contact of children with older adults other than their grandparents was limited, especially in work settings or schools. It was concluded that deliberate programming in preschools and elementary schools is important to offset early ageist attitude formation.

1. In this study, we examined the basal release of choriomammotropin (oCM) from monolayer cultures of cotyledonary cells obtained from ewes at different gestational ages. 2. oCM release increased with gestational age and displayed a similar profile to the concentration of oCM observed in maternal plasma. 3. Release of oCM was significantly (P less than 0.05; n = 9) increased in calcium-depleted medium, and by treatment with either phospholipase C (0.125 units/ml) or KCl (50 mM). 4. The calcium antagonist MgCl (12 mM) and the calcium channel-blocking agents verapamil (50 microM) and nefidipine (10 microM) all significantly stimulated oCM release. 5. These data are consistent with the suggestion that oCM release is inversely related to extracellular calcium concentration.