637 results on '"Burke, John E."'
Search Results
2. Free energy landscape of the PI3Kα C-terminal activation
3. Structure of calcineurin bound to PI4KA reveals dual interface in both PI4KA and FAM126A
4. Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket
5. Toxoplasma gondii mitochondrial association factor 1b interactome reveals novel binding partners including Ral GTPase accelerating protein α1
6. Beyond PI3Ks: targeting phosphoinositide kinases in disease
7. Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus
8. The middle lipin domain adopts a membrane-binding dimeric protein fold.
9. Accurate prediction of protein structures and interactions using a three-track neural network.
10. Structural basis for the conserved roles of PI4KA and its regulatory partners and their misregulation in disease
11. PI4KA and PIKfyve: Essential phosphoinositide signaling enzymes involved in myriad human diseases
12. Crystal structure of a lipin/Pah phosphatidic acid phosphatase
13. Publisher Correction: Crystal structure of a lipin/Pah phosphatidic acid phosphatase
14. Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs
15. ATP-competitive and allosteric inhibitors induce differential conformational changes at the autoinhibitory interface of Akt1
16. Molecular basis for the recruitment of the Rab effector protein WDR44 by the GTPase Rab11
17. Structure of autoinhibited Akt1 reveals mechanism of PIP₃-mediated activation
18. A previously uncharacterized O-glycopeptidase from Akkermansia muciniphila requires the Tn-antigen for cleavage of the peptide bond
19. Rapid, potent, and persistent covalent chemical probes to deconvolute PI3Kα signaling.
20. ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding.
21. Neolymphostin A Is a Covalent Phosphoinositide 3‑Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitor That Employs an Unusual Electrophilic Vinylogous Ester
22. Novel K‑Ras G12C Switch-II Covalent Binders Destabilize Ras and Accelerate Nucleotide Exchange
23. Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation
24. ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6-specific nanobody restricts M. tuberculosis growth in macrophages
25. Author response: ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6-specific nanobody restricts M. tuberculosis growth in macrophages
26. Structure of Calcineurin bound to PI4KA reveals dual interface in both PI4KA and FAM126A
27. Drugging the Phosphoinositide 3-Kinase (PI3K) and Phosphatidylinositol 4-Kinase (PI4K) Family of Enzymes for Treatment of Cancer, Immune Disorders, and Viral/Parasitic Infections
28. HDX-MS-optimized approach to characterize nanobodies as tools for biochemical and structural studies of class IB phosphoinositide 3-kinases
29. Biochemical Insight into Novel Rab-GEF Activity of the Mammalian TRAPPIII Complex
30. In vitro reconstitution of Sgk3 activation by phosphatidylinositol 3-phosphate
31. Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States
32. Expanding the Scope of Electrophiles Capable of Targeting K‑Ras Oncogenes
33. Integrated Structural Modeling of Full-Length LRH-1 Reveals Inter-domain Interactions Contribute to Receptor Structure and Function
34. Activation of Phospholipase C β by Gβγ and Gαq Involves C-Terminal Rearrangement to Release Autoinhibition
35. Novel roles of phosphoinositides in signaling, lipid transport, and disease
36. pH Biosensing by PI4P Regulates Cargo Sorting at the TGN
37. Defining How Oncogenic and Developmental Mutations of PIK3R1 Alter the Regulation of Class IA Phosphoinositide 3-Kinases
38. Class I phosphoinositide 3-kinase (PI3K) regulatory subunits and their roles in signaling and disease
39. Spartin-mediated lipid transfer facilitates lipid droplet turnover
40. Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ
41. Crystal structure of an archaeal CorB magnesium transporter
42. Palmitoylation targets the calcineurin phosphatase to the phosphatidylinositol 4-kinase complex at the plasma membrane
43. Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents
44. Probing Protein–Membrane Interactions and Dynamics Using Hydrogen–Deuterium Exchange Mass Spectrometry (HDX-MS)
45. The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzyme
46. A single discrete Rab5-binding site in phosphoinositide 3-kinase β is required for tumor cell invasion
47. Dynamic structural biology at the protein membrane interface
48. Structures of PI4KIIIβ complexes show simultaneous recruitment of Rab11 and its effectors
49. ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6 specific nanobody restricts M. tuberculosis growth in macrophages
50. Toxoplasma gondii Mitochondrial Association Factor 1b interactome reveals novel binding partners including Ral GTPase Accelerating Protein α1
Catalog
Books, media, physical & digital resources
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.