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4. A new measurement of the cross section of the inverse muon decay reaction νμ + e− → μ− + νe

Author

Geiregat, D., Vilain, P., Wilquet, G., Bergsma, F., Binder, U., Burkard, H., Eisenberg, Y., Flegel, W., Grote, H., Mouthuy, T., Øveras, H., Panman, J., Santacesaria, R., Winter, K., Zacek, G., Zacek, V., Beyer, R., Blobel, V., Büsser, F. W., Foos, C., Gerland, L., Layda, T., Niebergall, F., Raëdel, G., Stahëlin, P., Tadsen, A., Voss, T., Delbar, T., Favart, D., Gregoire, G., Knoops, E., Gorbunov, P., Grigoriev, E., Khovansky, V., Maslennikov, A., Rosanov, A., Lippich, W., Nathaniel, A., Staude, A., Caria, M., Eckart, B., Ereditato, A., Gorini, E., Grancagnolo, F., Iasevoli, R., Palladino, V., Strolin, P., Capone, Antonio, DE PEDIS, D., DI CAPUA, E., Dore, Ubaldo, Loverre, Pier Ferruccio, RAMBALDI FRENKEL, A., Piredda, G., and Zanello, D.

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, Muon, Large Hadron Collider, Physics::Instrumentation and Detectors, Electron, Standard Model, Nuclear physics, Cross section (physics), High Energy Physics::Experiment, Charm (quantum number), Neutrino, Particle Physics - Experiment, Beam (structure)
Abstract

We have measured the cross section for inverse muon decay in the CERN neutrino wide band beam. From 4808 events observed in the CHARM II detector we derived for the Born term of the asymptotic cross section slope the result (18.16±1.36) × 10 −42 cm 2 GeV −1 . This cross section is in good agreement with the standard model prediction and allows to constrain the scalar coupling of the electron and muon to their neutrinos to | g LL S | 2

Published
1990
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5. First observation of neutrino trident production

Author

Geiregat, D., Vilain, P., Wilquet, G., Bergsma, F., Binder, U., Burkard, H., Eisenberg, Y., Flegel, W., Grote, H., Mouthuy, T., Øveras, H., Panman, J., Santacesaria, R., Winter, K., Zacek, G., Zacek, V., Beyer, R., Blobel, V., Büsser, F. W., Foos, C., Gerland, L., Layda, T., Niebergall, F., Raëdel, G., Stahëlin, P., Tadsen, A., Voss, T., Delbar, T., Favart, D., Gregoire, G., Knoops, E., Gorbunov, P., Grigoriev, E., Khovansky, V., Maslennikov, A., Rosanov, A., Lippich, W., Nathaniel, A., Staude, A., Caria, M., Eckart, B., Ereditato, A., Gorini, E., Grancagnolo, F., Iasevoli, R., Palladino, V., Strolin, P., Capone, Antonio, DE PEDIS, D., DI CAPUA, E., Dore, Ubaldo, Loverre, Pier Ferruccio, RAMBALDI FRENKEL, A., Piredda, G., and Zanello, D.

Subjects
Electromagnetic field, Physics, Nuclear and High Energy Physics, Particle physics, Large Hadron Collider, Muon, Physics::Instrumentation and Detectors, Detector, Nuclear physics, Recoil, High Energy Physics::Experiment, Neutrino, Nuclear Experiment, Particle Physics - Experiment
Abstract

We report on the first observation of neutrino induced production of muon pairs in the electromagnetic field of a nucleus. The data has been obtained using the CHARM II detector exposed to the CERN wideband neutrino and antineutrino beams. A clear signal of 55 ± 16 events is seen in a sample of dimuons of opposite charge without visible recoil at the vertex. The cross section is determined and found to be in agreement with the standard model prediction.

Published
1990
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14. Calibration and performance of the CHARM-II detector

Author

Geiregat, D., primary, Vilain, P., additional, Wilquet, G., additional, Binder, U., additional, Burkard, H., additional, Flegel, W., additional, Grote, H., additional, Mouthuy, T., additional, Øverås, H., additional, Panman, J., additional, Rozanov, A., additional, Winter, K., additional, Zacek, G., additional, Zacek, V., additional, Beyer, R., additional, Büsser, F.W., additional, Foos, C., additional, Gerland, L., additional, Layda, T., additional, Niebergall, F., additional, Rädel, G., additional, Stähelin, P., additional, Tadsen, A., additional, Voss, T., additional, Favart, D., additional, Grégoire, G., additional, Knoops, E., additional, Lemaître, V., additional, Gorbunov, P., additional, Grigoriev, E., additional, Khovansky, V., additional, Maslennikov, A., additional, Lippich, W., additional, Nathaniel, A., additional, Neumeyer, H., additional, Staude, A., additional, Vogt, J., additional, Caria, M., additional, Cicalò, C., additional, Eckart, B., additional, Cocco, A.G., additional, Ereditato, A., additional, Fiorillo, G., additional, Mennella, S., additional, Palladino, V., additional, Paolucci, P., additional, Strolin, P., additional, Capone, A., additional, De Pedis, D., additional, Di Capua, E., additional, Dore, U., additional, Frenkel-Rambaldi, A., additional, Loverre, P.F., additional, Macina, D., additional, Piredda, G., additional, Santacesaria, R., additional, and Zanello, D., additional

Published
1993
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16. An improved determination of the electroweak mixing angle from muon-neutrino electron scattering

Author

Geiregat, D., primary, Vilain, P., additional, Wilquet, G., additional, Binder, U., additional, Burkard, H., additional, Dore, U., additional, Flegel, W., additional, Grote, H., additional, Mouthuy, T., additional, Øveras, H., additional, Panman, J., additional, Santacesaria, R., additional, Winter, K., additional, Zacek, G., additional, Zacek, V., additional, Beyer, R., additional, Büsser, F.W., additional, Foos, C., additional, Gerland, L., additional, Layda, T., additional, Niebergall, F., additional, Rädel, G., additional, Stähelin, P., additional, Tadsen, A., additional, Voss, T., additional, Delbar, Th., additional, Favart, D., additional, Grègoire, G., additional, Knoops, E., additional, Gorbunov, P., additional, Grigoriev, E., additional, Khovansky, V., additional, Maslennikov, A., additional, Rozanov, A., additional, Lippich, W., additional, Nathaniel, A., additional, Staude, A., additional, Caria, M., additional, Eckart, B., additional, Ereditato, A., additional, Gorini, E., additional, Grancagnolo, F., additional, Iasevoli, R., additional, Palladino, V., additional, Strolin, P., additional, Capone, A., additional, De Pedis, D., additional, Di Capua, E., additional, Frenkel-Rambaldi, A., additional, Loverre, P.F., additional, Piredda, G., additional, and Zanello, D., additional

Published
1991
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20. Neutrino-electron scattering: progress with the CHARM II detector

Author

De Winter, K, Geiregat, D, Vilain, P, Wilquet, G, Bergsma, F, Binder, U, Burkard, H, Capone, A, Ereditato, A, Flegel, Wilfried, Grote, H, Nieuwenhuis, C, Øverås, H, Palladino, Vittorio, Panman, J, Piredda, G, Winter, Klaus, Zacek, G, Zacek, V, Bauche, T, Beyer, R, Blobel, Volker, Büsser, F W, Foos, C, Gerland, L, Niebergall, F, Stähelin, P, Tadsen, A, Delbar, T, Emsens, B, Favart, D, Grégoire, G, Knoops, E, Mouthuy, T, Gorbunov, P, Grigoriev, E A, Khovanskii, V D, Maslennikov, A M, Rosanov, A, Lippich, W, Meyer-Berkhout, U, Nathaniel, A, Staude, A, Caria, M, Gorini, E, Grancagnolo, F, Iasevoli, R, Strolin, P, De Pedis, D, Di Capua, E, Dore, U, Loverre, P F, Rambaldi-Frenkel, A, Santacesaria, R, and Zanello, D

Subjects
Particle Physics - Experiment
Published
1988

24. A new determination of the electroweak mixing angle from muon-neutrino-electron scattering

Author

Geiregat, D., primary, Vilain, P., additional, Wilquet, G., additional, Bergsma, F., additional, Binder, U., additional, Burkard, H., additional, Eisenberg, Y., additional, Flegel, W., additional, Grote, H., additional, Mouthuy, T., additional, Øveras, H., additional, Panman, J., additional, Santacesaria, R., additional, Winter, K., additional, Zacek, G., additional, Zacek, V., additional, Beyer, R., additional, Blobel, V., additional, Büsser, F.W., additional, Foos, C., additional, Gerland, L., additional, Layda, T., additional, Niebergall, F., additional, Rädel, G., additional, Stähelin, P., additional, Tadsen, A., additional, Voss, T., additional, Delbar, Th., additional, Favart, D., additional, Grégoire, G., additional, Knoops, E., additional, Gorbunov, P., additional, Grigoriev, E., additional, Khovansky, V., additional, Maslennikov, A., additional, Rosanov, A., additional, Lippich, W., additional, Nathaniel, A., additional, Staude, A., additional, Caria, M., additional, Eckart, B., additional, Ereditato, A., additional, Gorini, E., additional, Grancagnolo, F., additional, Iasevoli, R., additional, Palladino, V., additional, Strolin, P., additional, Capone, A., additional, De Pedis, D., additional, Di Capua, E., additional, Dore, U., additional, Frenkel-Rambaldi, A., additional, Loverre, P.F., additional, Piredda, G., additional, and Zanello, D., additional

Published
1989
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25. A detector for the study of neutrino-electron scattering

Author

De Winter, K., primary, Dewulf, J.P., additional, Geiregat, D., additional, Vilain, P., additional, Wilquet, G., additional, Bergsma, F., additional, Binder, U., additional, Burkard, H., additional, Capone, A., additional, Flegel, W., additional, Friend, B., additional, Grote, H., additional, King, A., additional, Nieuwenhuis, C., additional, Øverås, H., additional, Palladino, V., additional, Panman, J., additional, Piredda, G., additional, Seiden, A., additional, Winter, K., additional, Zacek, G., additional, Zacek, V., additional, Bauche, T., additional, Beyer, R., additional, Blobel, V., additional, Büsser, F.W., additional, Foos, C., additional, Gerland, L., additional, Niebergall, F., additional, Riege, H., additional, Schütt, J., additional, Stähelin, P., additional, Tadsen, A., additional, Delbar, T., additional, Favart, D., additional, Grégoire, G., additional, Knoops, E., additional, Mouthuy, T., additional, Gorbunov, P., additional, Grigoriev, E., additional, Jemanov, V., additional, Khovansky, V., additional, Maslennikov, A., additional, Rosanov, A., additional, Braun, D., additional, Lippich, W., additional, Nathaniel, A., additional, Staude, A., additional, Caria, M., additional, Ereditato, A., additional, Gorini, E., additional, Grancagnolo, F., additional, Iasevoli, R., additional, Strolin, P., additional, Basti, G., additional, De Pedis, D., additional, Di Capua, E., additional, Dore, U., additional, Frenkel-Rambaldi, A., additional, Guerra, S., additional, Loverre, P.F., additional, Santacesaria, R., additional, and Zanello, D., additional

Published
1989
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26. Experimental results obtained from a low-Z, fine-grained electromagnetic calorimeter

Author

de Winter, K., primary, Geiregat, D., additional, Vilain, P., additional, Wilquet, G., additional, Bergsma, F., additional, Binder, U., additional, Burkard, H., additional, Capone, A., additional, Ereditato, A., additional, Flegel, W., additional, Grote, H., additional, Nieuwenhuis, C., additional, Øverås, H., additional, Palladino, V., additional, Panman, J., additional, Piredda, G., additional, Winter, K., additional, Zacek, G., additional, Zacek, V., additional, Bauche, T., additional, Beyer, R., additional, Blobel, V., additional, Büsser, F.W., additional, Foos, C., additional, Gerland, L., additional, Niebergall, F., additional, Stähelin, P., additional, Tadsen, A., additional, Delbar, T., additional, Emsens, B., additional, Favart, D., additional, Grégoire, G., additional, Knoops, E., additional, Mouthuy, T., additional, Gorbunov, P., additional, Grigoriev, E., additional, Khovansky, V., additional, Maslennikov, A., additional, Rosanov, A., additional, Lippich, W., additional, Nathaniel, A., additional, Staude, A., additional, Caria, M., additional, Gorini, E., additional, Grancagnolo, F., additional, Iasevoli, R., additional, Strolin, P., additional, de Pedis, D., additional, di Capua, E., additional, Dore, U., additional, Loverre, P.F., additional, Rambaldi-Frenkel, A., additional, Santacesaria, R., additional, and Zanello, D., additional

Published
1989
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28. An electron-hadron separator for digital sampling calorimeters

Author

De Winter, K., primary, Geiregat, D., additional, Vilain, P., additional, Wilquet, G., additional, Bergsma, F., additional, Binder, U., additional, Burkard, H., additional, Capone, A., additional, Ereditato, A., additional, Flegel, W., additional, Grote, H., additional, Nieuwenhuis, C., additional, Øverås, H., additional, Palladino, V., additional, Panman, J., additional, Piredda, G., additional, Winter, K., additional, Zacek, G., additional, Zacek, V., additional, Bauche, T., additional, Beyer, R., additional, Blobel, V., additional, Büsser, F.W., additional, Foos, C., additional, Gerland, L., additional, Niebergall, F., additional, Stähelin, P., additional, Tadsen, A., additional, Delbar, T., additional, Emsens, B., additional, Favart, D., additional, Grégoire, G., additional, Knoops, E., additional, Mouthuy, T., additional, Gorbunov, P., additional, Grigoriev, E., additional, Khovansky, V., additional, Maslennikov, A., additional, Rosanov, A., additional, Lippich, W., additional, Nathaniel, A., additional, Staude, A., additional, Caria, M., additional, Gorini, E., additional, Grancagnolo, F., additional, Iasevoli, R., additional, Strolin, P., additional, De Pedis, D., additional, Di Capua, E., additional, Dore, U., additional, Loverre, P.F., additional, Rambaldi-Frenkel, A., additional, Santacesaria, R., additional, and Zanello, D., additional

Published
1989
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31. The Neuroprotective Effects of Caffeine in a Neonatal Hypoxia-Ischemia Model are Regulated through the AMPK/mTOR Pathway.

Author

Bernis ME, Burkard H, Bremer AS, Grzelak K, Zweyer M, Maes E, Nacarkucuk E, Kaibel H, Hakvoort C, Müller A, and Sabir H

Subjects
Animals, Rats, Rats, Sprague-Dawley, AMP-Activated Protein Kinases metabolism, Signal Transduction drug effects, Disease Models, Animal, Caffeine pharmacology, Caffeine therapeutic use, Neuroprotective Agents therapeutic use, Neuroprotective Agents pharmacology, TOR Serine-Threonine Kinases metabolism, Hypoxia-Ischemia, Brain metabolism, Hypoxia-Ischemia, Brain drug therapy, Animals, Newborn
Abstract

Neonatal hypoxic-ischemic encephalopathy (HIE) is the most common cause of death and long-term disabilities in term neonates. Caffeine exerts anti-inflammatory effects and has been used in neonatal intensive care units in recent decades. In our neonatal rat model of hypoxic-ischemic (HI) brain injury, we demonstrated that a single daily dose of caffeine (40 mg/kg) for 3 days post-HI reduced brain tissue loss and microgliosis compared to the vehicle group. The AMPK/mTOR pathway plays an important role in sensing the stress responses following brain injury. However, the role of mTOR in HI-associated brain damage remains unclear. A detailed analysis of the AMPK/mTOR pathway in our model revealed that this pathway plays a key role in hypoxia-regulated neuroprotection and can be significantly influenced by caffeine treatment. Targeting HI with caffeine might offer effective neuroprotection, reduce mortality, and improve functional outcomes in patients with HIE, especially in low- and middle-income countries, where neuroprotective treatment is urgently needed., Competing Interests: Competing Interests: MEB and HS planned and designed the study. MEB, HS, MZ, and EM performed the animal surgery. MEB, HB, ASB, and EN performed the behavior tests. EN performed the MRI analysis. MEB, HS, MZ, and EM performed the isolation and purification of the samples. MEB and KG performed western blot analysis. MEB, MZ and EM performed tissue analysis. MEB, and HS analysed the data. MEB, and HS wrote and corrected the manuscript., (© The author(s).)

Published
2025
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32. Neuroprotective Effect of Melatonin in a Neonatal Hypoxia-Ischemia Rat Model Is Regulated by the AMPK/mTOR Pathway.

Author

Nacarkucuk E, Bernis ME, Bremer AS, Grzelak K, Zweyer M, Maes E, Burkard H, and Sabir H

Subjects
Animals, Oligodendroglia drug effects, Oligodendroglia metabolism, Oligodendroglia pathology, Brain drug effects, Brain metabolism, Brain pathology, Rats, Behavior, Animal drug effects, Melatonin pharmacology, Hypoxia-Ischemia, Brain metabolism, Hypoxia-Ischemia, Brain drug therapy, Hypoxia-Ischemia, Brain pathology, TOR Serine-Threonine Kinases metabolism, Animals, Newborn, Rats, Wistar, Neuroprotective Agents pharmacology, Disease Models, Animal, Signal Transduction drug effects, AMP-Activated Protein Kinases metabolism, AMP-Activated Protein Kinases drug effects, Autophagy drug effects
Abstract

Background: Melatonin has been shown to be neuroprotective in different animal models of neonatal hypoxic-ischemic brain injury. However, its exact molecular mechanism of action remains unknown. Our aim was to prove melatonin's short- and long-term neuroprotection and investigate its role on the AMPK (AMP-activated protein kinase)/mTOR (mammalian target of rapamycin) pathway following neonatal hypoxic-ischemic brain injury., Methods and Results: Seven-day-old Wistar rat pups were exposed to hypoxia-ischemia, followed by melatonin or vehicle treatment. Detailed analysis of the AMPK/mTOR/autophagy pathway, short- and long-term neuroprotection, myelination, and oligodendrogenesis was performed at different time points. At 7 days after hypoxia-ischemia, melatonin-treated animals showed a significant decrease in tissue loss, increased oligodendrogenesis, and myelination. Long-term neurobehavioral results showed significant motor improvement following melatonin treatment. Molecular pathway analysis showed a decrease in the AMPK expression, with a significant increase at mTOR's downstream substrates, and a significant decrease at the autophagy marker levels in the melatonin group compared with the vehicle group., Conclusions: Melatonin treatment reduced brain area loss and promoted oligodendrogenesis with a clear improvement of motor function. We found that melatonin associated neuroprotection is regulated via the AMPK/mTOR/autophagy pathway. Considering the beneficial effects of melatonin and the results of our study, melatonin seems to be an optimal candidate for the treatment of newborns with hypoxic-ischemic brain injury in high- as well as in low- and middle-income countries.

Published
2024
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33. Neuroprotective Effect of Clemastine Improved Oligodendrocyte Proliferation through the MAPK/ERK Pathway in a Neonatal Hypoxia Ischemia Rat Model.

Author

Bernis ME, Hakvoort C, Nacarkucuk E, Burkard H, Bremer AS, Zweyer M, Maes E, Grzelak KA, and Sabir H

Subjects
Animals, Rats, Rats, Sprague-Dawley, Oligodendroglia drug effects, Oligodendroglia metabolism, Neuroprotective Agents pharmacology, Neuroprotective Agents therapeutic use, Hypoxia-Ischemia, Brain drug therapy, Hypoxia-Ischemia, Brain metabolism, Hypoxia-Ischemia, Brain pathology, Clemastine pharmacology, MAP Kinase Signaling System drug effects, Animals, Newborn, Disease Models, Animal, Cell Proliferation drug effects
Abstract

Neonatal hypoxic-ischemic encephalopathy is the most common cause of long-term disability in term neonates, and white matter injury is the primary cause of cerebral palsy. Therapies that focus on the neuroprotection of myelination and oligodendrocyte proliferation could potentially ameliorate long-lasting neurological impairments after hypoxic-ischemic encephalopathy. Clemastine, a histamine H1 antagonist, has been shown to exert neuroprotective effects in multiple sclerosis and spinal cord injury by promoting oligodendrogenesis and re-myelination. In this study, we demonstrated the neuroprotective effects of clemastine in our rat model of neonatal hypoxic-ischemic brain injury. Animals received a single intraperitoneal injection of either vehicle or clemastine (10 mg/kg) for 6 consecutive days. Our results showed a significant reduction in white matter loss after treatment, with a clear effect of clemastine on oligodendrocytes, showing a significant increase in the number of Olig2+ cells. We characterized the MAPK/ERK pathway as a potential mechanistic pathway underlying the neuroprotective effects of clemastine. Altogether, our results demonstrate that clemastine is a potential compound for the treatment of hypoxic-ischemic encephalopathy, with a clear neuroprotective effect on white matter injury by promoting oligodendrogenesis.

Published
2024
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34. Peroral Endoscopic Myotomy for the Treatment of Achalasia in a 10-Year-Old Male Patient.

Author

Filser J, Dick A, Meyer T, Germer CT, and von Rahden BH

Abstract

Peroral endoscopic myotomy (POEM) is a new endoscopic treatment for achalasia with very good short-term results in adults. Data about POEM in pediatric patients are missing. We present the case of a 10-year-old male patient with type I (classic) achalasia, successfully treated with POEM. The procedure was accomplished in a similar fashion to the technique used in adults. Short-term results were fine, with a complete control of dysphagia and absence of reflux. We suggest that POEM is a suitable option in pediatric patients-similar to adults-but long-term results must be awaited.

Published
2015
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