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1. Vitamin D opposes multilineage cell differentiation induced by Notch inhibition and BMP4 pathway activation in human colon organoids

Author

Bustamante-Madrid, Pilar, Barbáchano, Antonio, Albandea-Rodríguez, David, Rodríguez-Cobos, Javier, Rodríguez-Salas, Nuria, Prieto, Isabel, Burgos, Aurora, Martínez de Villarreal, Jaime, Real, Francisco X., González-Sancho, José Manuel, Larriba, María Jesús, Lafarga, Miguel, Muñoz, Alberto, and Fernández-Barral, Asunción

Published
2024
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3. Accuracy of the Narrow-Band Imaging International Colorectal Endoscopic Classification System in Identification of Deep Invasion in Colorectal Polyps

Author

Muñoz, Guillermo, Peligros, Isabel, Tardio Baiges, Antoni, Elbouayadl, Liliam, Carames, Nuria, Iglesias, Mar, del Carmen, Sofía, González-Lois, Carmen, Núñez, Henar, García Hernández, Sonia, Guerra Pastrián, Laura, López Carreira, Montserrat, Casalots, Álex, Caminoa, Alejandra, Solano, Marina, López-Ibáñez, María, Llaó, Jordina, Estévez, Pamela, Rodríguez-Alcalde, Daniel, Soto, Santiago, Pantaleón, Miguel, Álvarez, Alberto, Zamora Martínez, Tomás, Pascual, Juan Manuel, Ducóns, Julio, García-Lledó, Javier, Porta, Francesc, Hernández, Vicent, Cubiella, Joaquin, Riu, Faust, Simón, Miguel Ángel, Martínez, David, Seoane, Agustín, Gomollón, Fernando, Cid, Lucía, Sostres, Carlos, Domínguez, Fulgencio, Macenlle, Ramiro Manuel, de la Revilla, Juan, Isava, Álvaro, Campo, Rafael, de la Poza, Gema, Martínez, Alfonso, Quintas, Paola, Sánchez, Eloy, Foruny, Jose Ramón, Marín, Eva, Martínez, José Luis, Castro, Maria Inés, González, Juan Ángel, Llop, Elba, Martín, Eduardo, Rey, Rafael, Sort, Pau, Montesinos, Jesús, Fornells, Marta, Ascon, Nadia, Puig, Ignasi, López-Cerón, María, Arnau, Anna, Rosiñol, Òria, Cuatrecasas, Miriam, Herreros-de-Tejada, Alberto, Ferrández, Ángel, Serra-Burriel, Miquel, Nogales, Óscar, Vida, Francesc, de Castro, Luisa, López-Vicente, Jorge, Vega, Pablo, Álvarez-González, Marco A., González-Santiago, Jesús, Hernández-Conde, Marta, Díez-Redondo, Pilar, Rivero-Sánchez, Liseth, Gimeno-García, Antonio Z., Burgos, Aurora, García-Alonso, Francisco Javier, Bustamante-Balén, Marco, Martínez-Bauer, Eva, Peñas, Beatriz, and Pellise, Maria

Published
2019
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4. Clinico-Pathological Features, Outcomes and Impacts of COVID-19 Pandemic on Patients with Early-Onset Colorectal Cancer: A Single-Institution Experience

Author

Martinez-Perez, Daniel, primary, Viñal, David, additional, Peña-Lopez, Jesús, additional, Jimenez-Bou, Diego, additional, Ruiz-Gutierrez, Iciar, additional, Martinez-Recio, Sergio, additional, Alameda-Guijarro, María, additional, Rueda-Lara, Antonio, additional, Martin-Montalvo, Gema, additional, Ghanem, Ismael, additional, Custodio, Ana Belén, additional, Trilla-Fuertes, Lucia, additional, Gamez-Pozo, Angelo, additional, Barbachano, Antonio, additional, Rodriguez-Cobos, Javier, additional, Bustamante-Madrid, Pilar, additional, Fernandez-Barral, Asuncion, additional, Burgos, Aurora, additional, Prieto-Nieto, Maria Isabel, additional, Pastrian, Laura Guerra, additional, González-Sancho, José Manuel, additional, Muñoz, Alberto, additional, Feliu, Jaime, additional, and Rodríguez-Salas, Nuria, additional

Published
2023
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10. Impact of COVID-19 pandemic on diagnosis, staging and outcomes of patients with early-onset colorectal cancer

Author

Martínez-Pérez, Daniel, Viñal, David, García Cuesta, Jose Ángel, Rueda-Lara, A., Ruiz Gutiérrez, Iciar, Jiménez-Bou, Diego, Peña-López, Jesús, Martín-Montalvo, Gema, Alameda-Guijarro, María, Gutiérrez-Sainz, Laura, Barbáchano, Antonio, Rodríguez-Cobos, Javier, Bustamante-Madrid, Pilar, Larriba, María Jesús, Fernández-Barral, Asunción, Burgos, Aurora, Prieto-Nieto, María Isabel, Guerra-Pastrián, Laura, González-Sancho, José Manuel, Rodríguez-Salas, Nuria, Martínez-Pérez, Daniel, Viñal, David, García Cuesta, Jose Ángel, Rueda-Lara, A., Ruiz Gutiérrez, Iciar, Jiménez-Bou, Diego, Peña-López, Jesús, Martín-Montalvo, Gema, Alameda-Guijarro, María, Gutiérrez-Sainz, Laura, Barbáchano, Antonio, Rodríguez-Cobos, Javier, Bustamante-Madrid, Pilar, Larriba, María Jesús, Fernández-Barral, Asunción, Burgos, Aurora, Prieto-Nieto, María Isabel, Guerra-Pastrián, Laura, González-Sancho, José Manuel, and Rodríguez-Salas, Nuria

Abstract

[Background]: Although we seem to be recovering from COVID-19, we are now facing the long-term consequence of the pandemic on vulnerable subgroup of patients such as patients with early-onset colorectal cancer (EOCRC). We aim to study how the COVID-19 pandemic affected the diagnosis and clinic-pathological characteristics, treatment and outcomes of patients with EOCRC., [Methods]: This is an observational retrospective study including patients with EOCRC diagnosed between September 2016 and August 2021 at Hospital Universitario La Paz, Madrid, Spain. Two cohorts were stablished: before and after March 14, 2020, the day of the first lockdown in Spain., [Results]: A total of 1409 patients with CRC were included. Of those, 5,2% were EOCRC (n=75). Fifty-five (73%) and 20 (27%) were diagnosed pre, and post pandemic. The rate of EOCRC diagnosis per month was 1,8 and 1,1 in the pre and postpandemic group, respectively. Fifty percent of patients in the postpandemic group were diagnosed with metastatic disease, while only 29% had stage IV at diagnosis in the prepandemic subgroup (P = 0,09). High tumor budding, surgical margins affected, lymphovascular, and perineural invasion were also pathological features more observed in the postpandemic subgroup, although results are not statistically significant. The differences between both groups are depicted. After a median follow-up of 23 months (33 and 14 months in the pre and postpandemic group, respectively), 11 patients have died (15%). Median overall survival (OS) was not reached in either group. At 12 months, 94% and 89% of patients were alive in the pre and postpandemic group, respectively., [Conclusions]: COVID-19 has influenced the diagnosis and staging of patients with EOCRC. Long-term follow-up is needed to assess the survival in this population. The role of primary care in the diagnosis and early referral of these patients is, more than ever, crucial.

Published
2023

11. Clinico-Pathological Features, Outcomes and Impacts of COVID-19 Pandemic on Patients with Early-Onset Colorectal Cancer: A Single-Institution Experience

Author

Instituto de Salud Carlos III, European Commission, Comunidad de Madrid, Martínez-Pérez, Daniel, Viñal, David, Peña-Lopez, Jesús, Jiménez-Bou, Diego, Ruiz-Gutiérrez, Iciar, Martínez-Recio, S., Alameda-Guijarro, María, Rueda-Lara, A., Martin-Montalvo, G., Ghanem, Ismael, Custodio, Ana Belén, Trilla-Fuertes, Lucía, Gámez, Ángelo, Barbáchano, Antonio, Rodríguez-Cobos, Javier, Bustamante-Madrid, Pilar, Fernández-Barral, Asunción, Burgos, Aurora, Prieto-Nieto, María Isabel, Pastrián, L. G., González-Sancho, José Manuel, Muñoz Terol, Alberto, Feliu, Jaime, Rodríguez-Salas, Nuria, Instituto de Salud Carlos III, European Commission, Comunidad de Madrid, Martínez-Pérez, Daniel, Viñal, David, Peña-Lopez, Jesús, Jiménez-Bou, Diego, Ruiz-Gutiérrez, Iciar, Martínez-Recio, S., Alameda-Guijarro, María, Rueda-Lara, A., Martin-Montalvo, G., Ghanem, Ismael, Custodio, Ana Belén, Trilla-Fuertes, Lucía, Gámez, Ángelo, Barbáchano, Antonio, Rodríguez-Cobos, Javier, Bustamante-Madrid, Pilar, Fernández-Barral, Asunción, Burgos, Aurora, Prieto-Nieto, María Isabel, Pastrián, L. G., González-Sancho, José Manuel, Muñoz Terol, Alberto, Feliu, Jaime, and Rodríguez-Salas, Nuria

Abstract

[Background]: The rising incidence of colorectal cancer (CRC) among young patients is alarming. We aim to characterize the clinico-pathological features and outcomes of patients with early-onset CRC (EOCRC), as well as the impacts of COVID-19 pandemic., [Methods]: We included all patients with pathologically confirmed diagnoses of CRC at Hospital Universitario La Paz from October 2016 to December 2021. The EOCRC cut-off age was 50 years old., [Results]: A total of 1475 patients diagnosed with CRC were included, eighty (5.4%) of whom had EOCRC. Significant differences were found between EOCRC and later-onset patients regarding T, N stage and metastatic presentation at diagnosis; perineural invasion; tumor budding; high-grade tumors; and signet ring cell histology, with all issues having higher prevalence in the early-onset group. More EOCRC patients had the RAS/ BRAF wild type. Chemotherapy was administered more frequently to patients with EOCRC. In the metastatic setting, the EOCRC group presented a significantly longer median OS. Regarding the COVID-19 pandemic, more patients with COVID-19 were diagnosed with metastatic disease (61%) in the year after the lockdown (14 March 2020) than in the pre-pandemic EOCRC group (29%)., [Conclusions]: EOCRC is diagnosed at a more advanced stage and with worse survival features in localized patients. More patients with EOCRC were diagnosed with metastatic disease in the year after the COVID-19 pandemic lockdown. The long-term consequences of COVID-19 are yet to be determined.

Published
2023

12. Impact of COVID-19 pandemic on diagnosis, staging, and outcomes of patients with early-onset colorectal cancer.

Author

Martinez-Perez, Daniel, primary, Viñal, David, additional, García Cuesta, Jose Ángel, additional, Rueda-Lara, Antonio, additional, Ruiz-Gutierrez, Iciar, additional, Jiménez-Bou, Diego, additional, Peña-Lopez, Jesus, additional, Martin-Montalvo, Gema, additional, Alameda-Guijarro, Maria, additional, Gutiérrez-Sainz, Laura, additional, Barbachano, Antonio, additional, Rodriguez-Cobos, Javier, additional, Bustamante-Madrid, Pilar, additional, Larriba, Maria Jesús, additional, Fernandez-Barral, Asuncion, additional, Burgos, Aurora, additional, Prieto-Nieto, Maria Isabel, additional, Pastrian, Laura Guerra, additional, Gonzalez-Sancho, Jose Manuel, additional, and Rodriguez Salas, Nuria, additional

Published
2023
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15. Clinico-pathological characteristics and outcomes of patients with early-onset colorectal cancer

Author

Viñal, David, Martínez-Recio, S., Ruiz, I., Jimenez-Bou, D., Peña, J., Martin-Montalvo, G., Rueda-Lara, A., Alameda, M., Prieto, Isabel, Muñoz, Alberto, Rodríguez-Cobos, Javier, Bustamante-Madrid, Pilar, Larriba, María Jesús, Ghanem, Ismael, Fernández-Barral, Asunción, Feliu, Jaime, Barbáchano, Antonio, González-Sancho, José Manuel, Burgos, Aurora, Pastrián, L. G., and Rodríguez-Salas, Nuria

Abstract

[Background]: The rising incidence of colorectal cancer (CRC) among young patients is alarming. We aim to characterize the clinico-pathological features and outcomes of patients with early-onset CRC (EOCRC)., [Methods]: We included all of the patients with pathologically confirmed diagnosis of CRC at Hospital Universitario La Paz from October 2016 to September 2020. EOCRC age cut-off was 50 years. All statistical analyses were carried out using SPSS v.25. [Results]: A total of 1152 patients were diagnosed with CRC, fifty-nine (5,1%) of them were After a median follow-up of 24 months, 279 patients have died. Median overall survival (OS) was not reached in either group (p ¼ 0,06). Three-year OS was 80% (95% CI: 73-87) and 67 (95%CI: 65-69) in the younger and older group, respectively. In patients with localized disease that underwent surgery or other antineoplastic treatment ( n ¼ 856), 159 events for disease-free survival (DFS) were observed. Median DFS was not reached in either group (p ¼0,144). Three-year DFS was 86% (95%CI: 79-93) and 73% (95%CI: 71-75, respectively). In patients with metastatic disease (n ¼ 332; synchronous or metachronic), median OS was not reach in the EOCRC group vs 18,1 (95%CI: 13,8-22,4), p ¼ 0,05). In those patients with metastatic EOCRC with mutational status assessed (n ¼23), no difference in OS according to RAS was observed (p ¼ 0,55)., [Conclusions]: Patients with EOCRC are diagnosed at a more advanced stage and display distinct biological features (more prevalence of dMMR and WT tumors among others). Studies focusing on screening in this population and deeper molecular profiling are needed.

Published
2022

16. P-40 Clinico-pathological characteristics and outcomes of patients with early-onset colorectal cancer

Author

Viñal, David, Martínez-Recio, S., Ruiz, I., Jiménez-Bou, Diego, Peña, J., Martin-Montalvo, G., Rueda-Lara, A., Alameda, M., Prieto, Isabel, Muñoz, Alberto, Rodríguez-Cobos, Javier, Bustamante-Madrid, Pilar, Larriba, María Jesús, Ghanem, Ismael, Fernández-Barral, Asunción, Feliu, Jaime, Barbáchano, Antonio, González-Sancho, José Manuel, Burgos, Aurora, Pastrián, L. G., Rodríguez-Salas, Nuria, Viñal, David, Martínez-Recio, S., Ruiz, I., Jiménez-Bou, Diego, Peña, J., Martin-Montalvo, G., Rueda-Lara, A., Alameda, M., Prieto, Isabel, Muñoz, Alberto, Rodríguez-Cobos, Javier, Bustamante-Madrid, Pilar, Larriba, María Jesús, Ghanem, Ismael, Fernández-Barral, Asunción, Feliu, Jaime, Barbáchano, Antonio, González-Sancho, José Manuel, Burgos, Aurora, Pastrián, L. G., and Rodríguez-Salas, Nuria

Abstract

[Background]: The rising incidence of colorectal cancer (CRC) among young patients is alarming. We aim to characterize the clinico-pathological features and outcomes of patients with early-onset CRC (EOCRC)., [Methods]: We included all of the patients with pathologically confirmed diagnosis of CRC at Hospital Universitario La Paz from October 2016 to September 2020. EOCRC age cut-off was 50 years. All statistical analyses were carried out using SPSS v.25. [Results]: A total of 1152 patients were diagnosed with CRC, fifty-nine (5,1%) of them were After a median follow-up of 24 months, 279 patients have died. Median overall survival (OS) was not reached in either group (p ¼ 0,06). Three-year OS was 80% (95% CI: 73-87) and 67 (95%CI: 65-69) in the younger and older group, respectively. In patients with localized disease that underwent surgery or other antineoplastic treatment ( n ¼ 856), 159 events for disease-free survival (DFS) were observed. Median DFS was not reached in either group (p ¼0,144). Three-year DFS was 86% (95%CI: 79-93) and 73% (95%CI: 71-75, respectively). In patients with metastatic disease (n ¼ 332; synchronous or metachronic), median OS was not reach in the EOCRC group vs 18,1 (95%CI: 13,8-22,4), p ¼ 0,05). In those patients with metastatic EOCRC with mutational status assessed (n ¼23), no difference in OS according to RAS was observed (p ¼ 0,55)., [Conclusions]: Patients with EOCRC are diagnosed at a more advanced stage and display distinct biological features (more prevalence of dMMR and WT tumors among others). Studies focusing on screening in this population and deeper molecular profiling are needed.

Published
2022

17. Compound Endoscopic Morphological Features for Identifying Non-Pedunculated Lesions ≥20 mm with Intramucosal Neoplasia

Author

da Costa-Seixas, João Pedro, primary, López-Cerón, María, additional, Arnau, Anna, additional, Rosiñol, Òria, additional, Cuatrecasas, Miriam, additional, Herreros-de-Tejada, Alberto, additional, Ferrández, Ángel, additional, Serra-Burriel, Miquel, additional, Nogales, Óscar, additional, de Castro, Luisa, additional, López-Vicente, Jorge, additional, Vega, Pablo, additional, Álvarez-González, Marco A., additional, González-Santiago, Jesús M., additional, Hernández-Conde, Marta, additional, Diez-Redondo, Pilar, additional, Rivero-Sánchez, Liseth, additional, Gimeno-García, Antonio Z., additional, Burgos, Aurora, additional, García-Alonso, Francisco Javier, additional, Bustamante-Balén, Marco, additional, Martínez-Bauer, Eva, additional, Peñas, Beatriz, additional, Rodríguez-Alcalde, Daniel, additional, Pellisé, Maria, additional, and Puig, Ignasi, additional

Published
2021
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19. Comparative study of organoids from patient-derived normal and tumor colon and rectal tissue

Author

Fernández-Barral, A., Costales-Carrera, Alba, Bustamante-Madrid, Pilar, Domínguez, Orlando, Guerra-Pastrián, Laura, Peso, Luis del, Burgos, Aurora, Barbáchano, Antonio, and Muñoz Terol, Alberto

Abstract

Trabajo presentado en el III Young Researchers Meeting from CIBERONC, celebrado en modalidad virutal del 14 al 15 de diciembre de 2020.

Published
2020

22. Comparative study of organoids from patient-derived normal and tumor colon and rectal tissue

Author

Fernández-Barral, Asunción, Costales-Carrera, Alba, Bustamante-Madrid, Pilar, Domínguez, Orlando, Guerra-Pastrián, Laura, Peso, Luis del, Burgos, Aurora, Barbáchano, Antonio, Muñoz Terol, Alberto, Fernández-Barral, Asunción, Costales-Carrera, Alba, Bustamante-Madrid, Pilar, Domínguez, Orlando, Guerra-Pastrián, Laura, Peso, Luis del, Burgos, Aurora, Barbáchano, Antonio, and Muñoz Terol, Alberto

Published
2020

23. Patient-derived organoids from normal and tumoral colorectal tissue

Author

Costales-Carrera, Alba, Bustamante-Madrid, Pilar, Burgos, Aurora, Barbáchano, Antonio, Muñoz Terol, Alberto, and Fernández-Barral, A.

Subjects
digestive system diseases
Abstract

Resumen del póster presentado al 42nd Congress of the Spanish Society of Biochemistry and Molecular Biology (SEBBM), celebrado en Madrid del 16 al 19 de julio de 2019., Colon and rectum are part of the same organ but have different embryological, anatomical and physiological characteristics. Although cancers from these two regions are often referred to as “colorectal cancer or CRC”, colon and rectal tumors differ in risk factors and mutational landscapes, which are analysed from complex heterotypic tumor biopsies. Accordingly, patients with colon or rectal tumors are managed differently in the clinic. Organoid technology allows the isolation and culture of normal and tumor stem cells, giving rise to structures that resemble functions and architecture of origin tissue or tumor. To gain further insight the transcriptomic and functional differences between colon and rectal cancers, we have generated two living biobank of 3D organoid cultures derived from human epithelial stem cells: a) the colon biobank from matched normal and tumor surgical samples of colon cancer patients; and b) a rectum biobank from endoscopy samples of normal rectum and rectal tumors, and when possible also from normal colon tissue, of rectal cancer patients. Endoscopy biopsies were obtained at diagnosis and so, they had never been exposed to radio- or chemotherapy. The study of functional behaviour and gene expression profiles of organoid cultures from colon and rectum will allow us to understand the possible differences between these two tissues in normal and tumoral conditions.

Published
2019

24. Transformacion lineal

Author

Espol, Yagual Burgos, Aurora C, and Zurita Herrera, Gaudencio Manfredo

Subjects
ALGEBRA LINEAL
Abstract

DENTRO DEL ESTUDIO DEL ÁLGEBRA LINEAL, TRATAMOS ACERCA DE UN TEMA ESPECIAL DE FUNCIONES LLAMADA TRANSFORMACIÓN LINEAL, PARA LO CUAL DAMOS UNA PEQUEÑA BIOGRAFÍA DE ARTHUR CAYLEY, QUIEN FUÉ UNO DE LOS MATEMÁTICOS QUE DIÓ A CONOCER ESTAS FUNCIONES. ARTHUR CAYLEY (1821 - 1895) NACIÓ EN RICHMOND, SURREY; ARTHUR FUÉ ENVIADO A UNA ESCUELA PRIVADA DE BLACKHEATH, A LOS 14 AÑOS AL KING`S COLLEGE SCHOOL DE LONDRES. Guayaquil MAGISTER EN EDUCACIÓN MATEMÁTICA

Published
2018

25. Accuracy of the Narrow-Band Imaging International Colorectal Endoscopic Classification System in Identification of Deep Invasion in Colorectal Polyps

Author

Puig, Ignasi, primary, López-Cerón, María, additional, Arnau, Anna, additional, Rosiñol, Òria, additional, Cuatrecasas, Miriam, additional, Herreros-de-Tejada, Alberto, additional, Ferrández, Ángel, additional, Serra-Burriel, Miquel, additional, Nogales, Óscar, additional, Vida, Francesc, additional, de Castro, Luisa, additional, López-Vicente, Jorge, additional, Vega, Pablo, additional, Álvarez-González, Marco A., additional, González-Santiago, Jesús, additional, Hernández-Conde, Marta, additional, Díez-Redondo, Pilar, additional, Rivero-Sánchez, Liseth, additional, Gimeno-García, Antonio Z., additional, Burgos, Aurora, additional, García-Alonso, Francisco Javier, additional, Bustamante-Balén, Marco, additional, Martínez-Bauer, Eva, additional, Peñas, Beatriz, additional, Pellise, Maria, additional, Muñoz, Guillermo, additional, Peligros, Isabel, additional, Tardio Baiges, Antoni, additional, Elbouayadl, Liliam, additional, Carames, Nuria, additional, Iglesias, Mar, additional, del Carmen, Sofía, additional, González-Lois, Carmen, additional, Núñez, Henar, additional, García Hernández, Sonia, additional, Guerra Pastrián, Laura, additional, López Carreira, Montserrat, additional, Casalots, Álex, additional, Caminoa, Alejandra, additional, Solano, Marina, additional, López-Ibáñez, María, additional, Llaó, Jordina, additional, Estévez, Pamela, additional, Rodríguez-Alcalde, Daniel, additional, Soto, Santiago, additional, Pantaleón, Miguel, additional, Álvarez, Alberto, additional, Zamora Martínez, Tomás, additional, Pascual, Juan Manuel, additional, Ducóns, Julio, additional, García-Lledó, Javier, additional, Porta, Francesc, additional, Hernández, Vicent, additional, Cubiella, Joaquin, additional, Riu, Faust, additional, Simón, Miguel Ángel, additional, Martínez, David, additional, Seoane, Agustín, additional, Gomollón, Fernando, additional, Cid, Lucía, additional, Sostres, Carlos, additional, Domínguez, Fulgencio, additional, Macenlle, Ramiro Manuel, additional, de la Revilla, Juan, additional, Isava, Álvaro, additional, Campo, Rafael, additional, de la Poza, Gema, additional, Martínez, Alfonso, additional, Quintas, Paola, additional, Sánchez, Eloy, additional, Foruny, Jose Ramón, additional, Marín, Eva, additional, Martínez, José Luis, additional, Castro, Maria Inés, additional, González, Juan Ángel, additional, Llop, Elba, additional, Martín, Eduardo, additional, Rey, Rafael, additional, Sort, Pau, additional, Montesinos, Jesús, additional, Fornells, Marta, additional, and Ascon, Nadia, additional

Published
2019
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26. Su1702 Diagnostic Accuracy of the Nice Classification for Predicting Deep Submucosal Invasion in Colon Lesions Assessed In Vivo

Author

Puig, Ignasi, primary, Lopez-Ceron, Maria, additional, Rosiñol, Oria, additional, Cuatrecasas, Miriam, additional, Arnau, Anna, additional, Herreros-de-Tejada, Alberto, additional, Ferrandez, Angel, additional, Vida, Francesc, additional, Nogales Rincon, Oscar, additional, De Castro, Luisa, additional, López-Vicente, Jorge, additional, Vega, Pablo, additional, Alvarez-Gonzalez, Marco A., additional, Gonzalez-Santiago, Jesus M., additional, Hernandez-Conde, Marta, additional, Diez-Redondo, Pilar, additional, Sanchez, Liseth Rivero, additional, Gimeno-García, Antonio Z., additional, Burgos, Aurora, additional, Garcia-Alonso, Javier, additional, Martinez-Bauer, Eva, additional, Peñas, Beatriz, additional, Muñoz, Guillermo, additional, Peligros, Isabel, additional, Tardio Baiges, Antonio, additional, Gonzalez Lois, Carmen, additional, Pastrian, Laura Guerra, additional, Garcia Hernandez, Sonia, additional, Caminoa, Alejandra, additional, Zamora Martinez, Tomas, additional, El Bouayadi, Liliam, additional, Lopez Carreira, Montserrat, additional, Casalots Casado, Alex, additional, Carames Diaz, Nuria Maria, additional, Iglesias, Mar, additional, del Carmen, Sofía, additional, López-Ibáñez, Maria, additional, Pantaleón, Miguel Ángel, additional, Solano, Marina, additional, Alvarez, Alberto, additional, Soto, Santiago, additional, Estévez, Pamela, additional, Alcalde, Daniel Rodríguez, additional, Bustamante, Marco, additional, and Pellise, Maria, additional

Published
2017
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27. Su1708 Diagnostic Accuracy of the Nice Classification for Predicting Deep Submucosal Invasion in Colon Lesions Assessed In Vivo Preliminary Results

Author

Puig, Ignasi, primary, Lopez-Ceron, Maria, additional, Pellise, Maria, additional, Herreros-de-Tejada, Alberto, additional, Arnau, Anna, additional, Rosiñol, Òria, additional, Cuatrecasas, Miriam, additional, Ascon, Nàdia, additional, López-Vicente, Jorge, additional, De-Castro, Luisa, additional, Vega, Pablo, additional, Rincon, Oscar Nogales, additional, Nuñez, Henar, additional, Hernández-Conde, Marta, additional, Gimeno-García, Antonio Z., additional, Ferrández, Ángel, additional, Burgos, Aurora, additional, Sanchez, Liseth Rivero, additional, García-Alonso, Javier, additional, Martinez-Bauer, Eva, additional, Mendoza, Jorge, additional, Rodríguez-Alcalde, Daniel, additional, Diez-Redondo, Pilar, additional, Estévez, Pamela, additional, Hernandez, Vicent, additional, Llao, Jordina, additional, Soto, Santiago, additional, Ducóns, Julio, additional, Martínez-Ares, David, additional, Pascual, Juan Manuel, additional, Porta, Francesc, additional, Cubiella, Joaquín, additional, Domínguez, Fulgencio, additional, Cid, Lucía, additional, and Vida, Francesc, additional

Published
2016
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28. Su1707 Diagnostic Accuracy of the NICE Classification for Predicting Deep Submucosal Invasion in Colon Lesions Assessed Ex Vivo

Author

Puig, Ignasi, primary, Lopez-Ceron, Maria, additional, Pellise, Maria, additional, Herreros-de-Tejada, Alberto, additional, Arnau, Anna, additional, López-Vicente, Jorge, additional, De-Castro, Luisa, additional, Vega, Pablo, additional, Rincon, Oscar Nogales, additional, Nuñez, Henar, additional, Hernández-Conde, Marta, additional, Gimeno-García, Antonio Z., additional, Ferrández, Ángel, additional, Burgos, Aurora, additional, Sanchez, Liseth Rivero, additional, García-Alonso, Javier, additional, Martinez-Bauer, Eva, additional, Mendoza, Jorge, additional, Rodríguez-Alcalde, Daniel, additional, Diez-Redondo, Pilar, additional, Estévez, Pamela, additional, Hernandez, Vicent, additional, Llao, Jordina, additional, Soto, Santiago, additional, Ducóns, Julio, additional, Martínez-Ares, David, additional, Pascual, Juan Manuel, additional, Porta, Francesc, additional, Cubiella, Joaquín, additional, Domínguez, Fulgencio, additional, Cid, Lucía, additional, Isava, Álvaro, additional, Alvarez-Gonzalez, Marco A., additional, Peñas, Beatriz, additional, and Vida, Francesc, additional

Published
2016
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32. Diagnostic Accuracy of the Nice Classification for Predicting Deep Submucosal Invasion in Colon Lesions Assessed In Vivo Preliminary Results

Author

Puig, Ignasi, Lopez-Ceron, Maria, Pellise, Maria, Herreros-De-Tejada, Alberto, Arnau, Anna, Rosinol, Oria, Cuatrecasas, Miriam, Ascon, Nadia, Lopez-Vicente, Jorge, De-Castro, Luisa, Vega, Pablo, Nogales Rincon, Oscar, Nunez, Henar, Hernandez-Conde, Marta, Gimeno-Garcia, Antonio Z., Ferrandez, Angel, Burgos, Aurora, Rivero Sanchez, Liseth, Garcia-Alonso, Javier, Martinez-Bauer, Eva, Mendoza, Jorge, Daniel Rodriguez-Alcalde, Diez-Redondo, Pilar, Estevez, Pamela, Hernandez, Vicent, Llao, Jordina, Soto, Santiago, Ducons, Julio, Martinez-Ares, David, Manuel Pascual, Juan, Porta, Francesc, Cubiella, Joaquin, Dominguez, Fulgencio, Cid, Lucia, and Vida, Francesc

33. Diagnostic Accuracy of the NICE Classification for Predicting Deep Submucosal Invasion in Colon Lesions Assessed Ex Vivo

Author

Puig, Ignasi, Lopez-Ceron, Maria, Pellise, Maria, Herreros-De-Tejada, Alberto, Arnau, Anna, Lopez-Vicente, Jorge, De-Castro, Luisa, Vega, Pablo, Nogales Rincon, Oscar, Nunez, Henar, Hernandez-Conde, Marta, Gimeno-Garcia, Antonio Z., Ferrandez, Angel, Burgos, Aurora, Rivero Sanchez, Liseth, Garcia-Alonso, Javier, Martinez-Bauer, Eva, Mendoza, Jorge, Daniel Rodriguez-Alcalde, Diez-Redondo, Pilar, Estevez, Pamela, Hernandez, Vicent, Llao, Jordina, Soto, Santiago, Ducons, Julio, Martinez-Ares, David, Manuel Pascual, Juan, Porta, Francesc, Cubiella, Joaquin, Dominguez, Fulgencio, Cid, Lucia, Isava, Alvaro, Alvarez-Gonzalez, Marco A., Penas, Beatriz, and Vida, Francesc

35. [Neurological complications of Wilson's disease].

Author

Burgos A and Bermejo PE

Subjects
Animals, Basal Ganglia Diseases etiology, Basal Ganglia Diseases pathology, Central Nervous System metabolism, Central Nervous System pathology, Chelating Agents therapeutic use, Chelation Therapy, Copper pharmacokinetics, Epilepsy etiology, Epilepsy physiopathology, Hepatolenticular Degeneration drug therapy, Hepatolenticular Degeneration metabolism, Hepatolenticular Degeneration psychology, Hepatolenticular Degeneration surgery, Humans, Liver Transplantation, Models, Animal, Necrosis, Zinc therapeutic use, Hepatolenticular Degeneration complications, Mental Disorders etiology, Movement Disorders etiology
Published
2011
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36. [Neurological complications of inflammatory bowel disease].

Author

Bermejo PE and Burgos A

Subjects
Brain physiopathology, Brain Ischemia physiopathology, Cognition Disorders physiopathology, Epilepsy epidemiology, Epilepsy physiopathology, Hearing Loss, Sensorineural epidemiology, Hearing Loss, Sensorineural physiopathology, Humans, Mental Disorders epidemiology, Mental Disorders psychology, Multiple Sclerosis epidemiology, Myasthenia Gravis epidemiology, Papilledema epidemiology, Spinal Cord Diseases epidemiology, Vasculitis, Central Nervous System physiopathology, Brain Ischemia epidemiology, Cognition Disorders epidemiology, Inflammatory Bowel Diseases complications, Inflammatory Bowel Diseases epidemiology, Nervous System Diseases etiology, Vasculitis, Central Nervous System epidemiology
Abstract

Although ulcerative colitis and Crohn's disease have traditionally been considered to be inflammatory diseases limited to the gastrointestinal tract, it has been shown that both pathologies are frequently accompanied by various extraintestinal disorders. There is an increasing evidence that they may also manifest in the nervous system, including the peripheral and the central parts. Although some of these neurological complications have been known for a long time, such as cerebrovascular disease, vasculitis and autoinmune processes including neuropathies and cerebral demyelination, others have been recently described. With the exception of some of this complications such as the thromboembolism, evidence for a casual relationship relies merely on single case reports or case series. In this article, we try to review the existing evidence on neurological manifestations of both variants of inflammatory bowel disease.

Published
2008
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37. [Whipple's disease and central nervous system].

Author

Bermejo P and Burgos A

Subjects
Anti-Bacterial Agents therapeutic use, Central Nervous System Diseases diagnosis, Central Nervous System Diseases drug therapy, Clinical Trials as Topic, Humans, Whipple Disease diagnosis, Whipple Disease drug therapy, Central Nervous System Diseases etiology, Whipple Disease complications
Published
2006
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