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6. Supplementary Figures from In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models

Author

Hughes, Paul E., primary, Rex, Karen, primary, Caenepeel, Sean, primary, Yang, Yajing, primary, Zhang, Yihong, primary, Broome, Martin A., primary, Kha, Hue T., primary, Burgess, Teresa L., primary, Amore, Benny, primary, Kaplan-Lefko, Paula J., primary, Moriguchi, Jodi, primary, Werner, Jonathan, primary, Damore, Michael A., primary, Baker, Daniel, primary, Choquette, Deborah M., primary, Harmange, Jean-Christophe, primary, Radinsky, Robert, primary, Kendall, Richard, primary, Dussault, Isabelle, primary, and Coxon, Angela, primary

Published
2023
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7. Supplementary Table S1 from In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models

Author

Hughes, Paul E., primary, Rex, Karen, primary, Caenepeel, Sean, primary, Yang, Yajing, primary, Zhang, Yihong, primary, Broome, Martin A., primary, Kha, Hue T., primary, Burgess, Teresa L., primary, Amore, Benny, primary, Kaplan-Lefko, Paula J., primary, Moriguchi, Jodi, primary, Werner, Jonathan, primary, Damore, Michael A., primary, Baker, Daniel, primary, Choquette, Deborah M., primary, Harmange, Jean-Christophe, primary, Radinsky, Robert, primary, Kendall, Richard, primary, Dussault, Isabelle, primary, and Coxon, Angela, primary

Published
2023
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8. Supplementary Data File 1 from In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models

Author

Hughes, Paul E., primary, Rex, Karen, primary, Caenepeel, Sean, primary, Yang, Yajing, primary, Zhang, Yihong, primary, Broome, Martin A., primary, Kha, Hue T., primary, Burgess, Teresa L., primary, Amore, Benny, primary, Kaplan-Lefko, Paula J., primary, Moriguchi, Jodi, primary, Werner, Jonathan, primary, Damore, Michael A., primary, Baker, Daniel, primary, Choquette, Deborah M., primary, Harmange, Jean-Christophe, primary, Radinsky, Robert, primary, Kendall, Richard, primary, Dussault, Isabelle, primary, and Coxon, Angela, primary

Published
2023
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9. Supplementary Data File 2 from In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models

Author

Hughes, Paul E., primary, Rex, Karen, primary, Caenepeel, Sean, primary, Yang, Yajing, primary, Zhang, Yihong, primary, Broome, Martin A., primary, Kha, Hue T., primary, Burgess, Teresa L., primary, Amore, Benny, primary, Kaplan-Lefko, Paula J., primary, Moriguchi, Jodi, primary, Werner, Jonathan, primary, Damore, Michael A., primary, Baker, Daniel, primary, Choquette, Deborah M., primary, Harmange, Jean-Christophe, primary, Radinsky, Robert, primary, Kendall, Richard, primary, Dussault, Isabelle, primary, and Coxon, Angela, primary

Published
2023
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10. Supplementary methods from In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models

Author

Hughes, Paul E., primary, Rex, Karen, primary, Caenepeel, Sean, primary, Yang, Yajing, primary, Zhang, Yihong, primary, Broome, Martin A., primary, Kha, Hue T., primary, Burgess, Teresa L., primary, Amore, Benny, primary, Kaplan-Lefko, Paula J., primary, Moriguchi, Jodi, primary, Werner, Jonathan, primary, Damore, Michael A., primary, Baker, Daniel, primary, Choquette, Deborah M., primary, Harmange, Jean-Christophe, primary, Radinsky, Robert, primary, Kendall, Richard, primary, Dussault, Isabelle, primary, and Coxon, Angela, primary

Published
2023
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11. Supplementary Data from Safety, Pharmacokinetics, and Pharmacodynamics of AMG 102, a Fully Human Hepatocyte Growth Factor–Neutralizing Monoclonal Antibody, in a First-in-Human Study of Patients with Advanced Solid Tumors

Author

Gordon, Michael S., primary, Sweeney, Christopher J., primary, Mendelson, David S., primary, Eckhardt, S. Gail, primary, Anderson, Abraham, primary, Beaupre, Darrin M., primary, Branstetter, Daniel, primary, Burgess, Teresa L., primary, Coxon, Angela, primary, Deng, Hongjie, primary, Kaplan-Lefko, Paula, primary, Leitch, Ian M., primary, Oliner, Kelly S., primary, Yan, Lucy, primary, Zhu, Min, primary, and Gore, Lia, primary

Published
2023
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12. Supplementary Data from Selective and Potent Raf Inhibitors Paradoxically Stimulate Normal Cell Proliferation and Tumor Growth

Author

Carnahan, Josette, primary, Beltran, Pedro J., primary, Babij, Carol, primary, Le, Quynh, primary, Rose, Mark J., primary, Vonderfecht, Steven, primary, Kim, Joseph L., primary, Smith, Adrian L., primary, Nagapudi, Karthik, primary, Broome, Martin A., primary, Fernando, Manory, primary, Kha, Hue, primary, Belmontes, Brian, primary, Radinsky, Robert, primary, Kendall, Richard, primary, and Burgess, Teresa L., primary

Published
2023
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13. Supplementary Tables 1-2 from Biochemical Characterization of AMG 102: A Neutralizing, Fully Human Monoclonal Antibody to Human and Nonhuman Primate Hepatocyte Growth Factor

Author

Burgess, Teresa L., primary, Sun, Jan, primary, Meyer, Susanne, primary, Tsuruda, Trace S., primary, Sun, Jilin, primary, Elliott, Gary, primary, Chen, Qing, primary, Haniu, Mitsuru, primary, Barron, Will F., primary, Juan, Todd, primary, Zhang, Ke, primary, Coxon, Angela, primary, and Kendall, Richard L., primary

Published
2023
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14. Supplementary Figure 1 from Biochemical Characterization of AMG 102: A Neutralizing, Fully Human Monoclonal Antibody to Human and Nonhuman Primate Hepatocyte Growth Factor

Author

Burgess, Teresa L., primary, Sun, Jan, primary, Meyer, Susanne, primary, Tsuruda, Trace S., primary, Sun, Jilin, primary, Elliott, Gary, primary, Chen, Qing, primary, Haniu, Mitsuru, primary, Barron, Will F., primary, Juan, Todd, primary, Zhang, Ke, primary, Coxon, Angela, primary, and Kendall, Richard L., primary

Published
2023
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15. Supplementary Figure Legend from Biochemical Characterization of AMG 102: A Neutralizing, Fully Human Monoclonal Antibody to Human and Nonhuman Primate Hepatocyte Growth Factor

Author

Burgess, Teresa L., primary, Sun, Jan, primary, Meyer, Susanne, primary, Tsuruda, Trace S., primary, Sun, Jilin, primary, Elliott, Gary, primary, Chen, Qing, primary, Haniu, Mitsuru, primary, Barron, Will F., primary, Juan, Todd, primary, Zhang, Ke, primary, Coxon, Angela, primary, and Kendall, Richard L., primary

Published
2023
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16. Supplementary Methods and Tables 1 - 3 from Safety, Pharmacokinetics, and Pharmacodynamics of AMG 102, a Fully Human Hepatocyte Growth Factor–Neutralizing Monoclonal Antibody, in a First-in-Human Study of Patients with Advanced Solid Tumors

Author

Gordon, Michael S., primary, Sweeney, Christopher J., primary, Mendelson, David S., primary, Eckhardt, S. Gail, primary, Anderson, Abraham, primary, Beaupre, Darrin M., primary, Branstetter, Daniel, primary, Burgess, Teresa L., primary, Coxon, Angela, primary, Deng, Hongjie, primary, Kaplan-Lefko, Paula, primary, Leitch, Ian M., primary, Oliner, Kelly S., primary, Yan, Lucy, primary, Zhu, Min, primary, and Gore, Lia, primary

Published
2023
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17. Supplementary Figure Legends 1-3 from Identification of a Novel Recepteur d'Origine Nantais/c-Met Small-Molecule Kinase Inhibitor with Antitumor Activity In vivo

Author

Zhang, Yihong, primary, Kaplan-Lefko, Paula J., primary, Rex, Karen, primary, Yang, Yajing, primary, Moriguchi, Jodi, primary, Osgood, Tao, primary, Mattson, Bethany, primary, Coxon, Angela, primary, Reese, Monica, primary, Kim, Tae-Seong, primary, Lin, Jasmine, primary, Chen, April, primary, Burgess, Teresa L., primary, and Dussault, Isabelle, primary

Published
2023
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18. Supplementary Figure 1 from Identification of a Novel Recepteur d'Origine Nantais/c-Met Small-Molecule Kinase Inhibitor with Antitumor Activity In vivo

Author

Zhang, Yihong, primary, Kaplan-Lefko, Paula J., primary, Rex, Karen, primary, Yang, Yajing, primary, Moriguchi, Jodi, primary, Osgood, Tao, primary, Mattson, Bethany, primary, Coxon, Angela, primary, Reese, Monica, primary, Kim, Tae-Seong, primary, Lin, Jasmine, primary, Chen, April, primary, Burgess, Teresa L., primary, and Dussault, Isabelle, primary

Published
2023
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19. Supplementary Figure 2 from Identification of a Novel Recepteur d'Origine Nantais/c-Met Small-Molecule Kinase Inhibitor with Antitumor Activity In vivo

Author

Zhang, Yihong, primary, Kaplan-Lefko, Paula J., primary, Rex, Karen, primary, Yang, Yajing, primary, Moriguchi, Jodi, primary, Osgood, Tao, primary, Mattson, Bethany, primary, Coxon, Angela, primary, Reese, Monica, primary, Kim, Tae-Seong, primary, Lin, Jasmine, primary, Chen, April, primary, Burgess, Teresa L., primary, and Dussault, Isabelle, primary

Published
2023
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22. Supplementary Figure 3 from Identification of a Novel Recepteur d'Origine Nantais/c-Met Small-Molecule Kinase Inhibitor with Antitumor Activity In vivo

Author

Zhang, Yihong, primary, Kaplan-Lefko, Paula J., primary, Rex, Karen, primary, Yang, Yajing, primary, Moriguchi, Jodi, primary, Osgood, Tao, primary, Mattson, Bethany, primary, Coxon, Angela, primary, Reese, Monica, primary, Kim, Tae-Seong, primary, Lin, Jasmine, primary, Chen, April, primary, Burgess, Teresa L., primary, and Dussault, Isabelle, primary

Published
2023
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24. Data from Identification of a Novel Recepteur d'Origine Nantais/c-Met Small-Molecule Kinase Inhibitor with Antitumor Activity In vivo

Author

Zhang, Yihong, primary, Kaplan-Lefko, Paula J., primary, Rex, Karen, primary, Yang, Yajing, primary, Moriguchi, Jodi, primary, Osgood, Tao, primary, Mattson, Bethany, primary, Coxon, Angela, primary, Reese, Monica, primary, Kim, Tae-Seong, primary, Lin, Jasmine, primary, Chen, April, primary, Burgess, Teresa L., primary, and Dussault, Isabelle, primary

Published
2023
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25. β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Author

Vassar, Robert, Bennett, Brian D, Babu-Khan, Safura, Kahn, Steve, Mendiaz, Elizabeth A, Denis, Paul, Teplow, David B, Ross, Sandra, Amarante, Patricia, Loeloff, Richard, Luo, Yi, Fisher, Seth, Fuller, Janis, Edenson, Steven, Lile, Jackson, Jarosinski, Mark A, Biere, Anja Leona, Curran, Eileen, Burgess, Teresa, Louis, Jean-Claude, Collins, Frank, Treanor, James, Rogers, Gary, and Citron, Martin

Subjects
Dementia, Acquired Cognitive Impairment, Neurodegenerative, Alzheimer's Disease, Aging, Brain Disorders, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Biotechnology, Neurosciences, Neurological, Alzheimer Disease, Amino Acid Motifs, Amino Acid Sequence, Amyloid Precursor Protein Secretases, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Animals, Aspartic Acid Endopeptidases, Binding Sites, Brain, Cell Line, Cloning, Molecular, Endopeptidases, Endosomes, Gene Expression, Gene Library, Golgi Apparatus, Humans, Hydrogen-Ion Concentration, Molecular Sequence Data, Oligonucleotides, Antisense, Peptides, Protease Inhibitors, RNA, Messenger, Recombinant Fusion Proteins, Transfection, General Science & Technology
Abstract

Cerebral deposition of amyloid beta peptide (Abeta) is an early and critical feature of Alzheimer's disease. Abeta generation depends on proteolytic cleavage of the amyloid precursor protein (APP) by two unknown proteases: beta-secretase and gamma-secretase. These proteases are prime therapeutic targets. A transmembrane aspartic protease with all the known characteristics of beta-secretase was cloned and characterized. Overexpression of this protease, termed BACE (for beta-site APP-cleaving enzyme) increased the amount of beta-secretase cleavage products, and these were cleaved exactly and only at known beta-secretase positions. Antisense inhibition of endogenous BACE messenger RNA decreased the amount of beta-secretase cleavage products, and purified BACE protein cleaved APP-derived substrates with the same sequence specificity as beta-secretase. Finally, the expression pattern and subcellular localization of BACE were consistent with that expected for beta-secretase. Future development of BACE inhibitors may prove beneficial for the treatment of Alzheimer's disease.

Published
1999

31. Developing and Evaluating the GriefLink Web Site: Processes, Protocols, Dilemmas and Lessons Learned

Author

Clark, Sheila, Burgess, Teresa, and Laven, Gillian

Abstract

Despite a profusion of recommendations regarding the quality of web sites and guidelines related to ethical issues surrounding health-related sites, there is little guidance for the design and evaluation of sites relating to loss and grief. This article, which addresses these deficiencies, results from a community consultation process of designing and evaluating a web site--GriefLink--for bereaved consumers and for the professionals who help them. It presents the literature review that informed the project, the recommendations for design and content, the lessons learned through the process itself, and the difficulties of evaluating the benefits of a grief-related web site. Some ethical and legal dilemmas in developing grief-related web sites are discussed and issues of design, content, process, evaluation, and general features are addressed, which may also be applied to other communication forms for loss and grief matters, such as the print media.

Published
2004

40. Developing and evaluating the GriefLink Web site: processes, protocols, dilemmas and lessons learned

Author

Clark, Sheila, Burgess, Teresa, Laven, Gillian, Bull, Michael, Marker, Julie, and Browne, Eric

Subjects
Web sites -- Usage, Grief, Bereavement, Web site/Web page development, Company Web site/Web page, Psychology and mental health, Sociology and social work
Abstract

Despite a profusion of recommendations regarding the quality of web sites and guidelines related to ethical issues surrounding health-related sites, there is little guidance for the design and evaluation of sites relating to loss and grief . This article, which addresses these deficiencies, results from a community consultation process of designing and evaluating a web site--GriefLink--for bereaved consumers and for the professionals who help them. It presents the literature review that informed the project, the recommendations for design and content, the lessons learned through the process itself, and the difficulties of evaluating the benefits of a grief-related web site. Some ethical and legal dilemmas in developing grief-related web sites are discussed and issues of design, content, process, evaluation, and general features are addressed, which may also be applied to other communication forms for loss and grief matters, such as the print media.

Published
2004

41. Electronic medical records may be inadequate for improving population health status through general practice: cervical smears as a case study

Author

Laurence, Caroline O.M., Burgess, Teresa, Beilby, Justin, Symon, Brian, and Wilkinson, David

Subjects
Family medicine, Health care reform, Medical records, Health
Abstract

Objective: To determine whether routine electronic records are an accurate source of population health data in general practice through reviewing cervical smears rates in four South Australian practices. Methods: The cervical screening rate in a purposive sample of four general practices (three rural and one urban) was obtained using an audit of medical records and a telephone follow-up. Results: The cervical screening rate using only immediately available electronic medical records indicated an overall low rate for the participating practices (44.9%). However, telephone follow-up and adjustments to the denominator indicated the real rate to be 85.7%. The offer of appointments during the telephone follow-up further improved this rate for eligible women (93.8%). Conclusions and implications: Electronic medical records may be inadequate in preventive screening in general practice, without ensuring their accuracy. Updating records by telephone or personal follow-up produces a much more accurate denominator.

Published
2004

47. Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors

Author

Miller, Thomas W., primary, Amason, Joshua D., additional, Garcin, Elsa D., additional, Lamy, Laurence, additional, Dranchak, Patricia K., additional, Macarthur, Ryan, additional, Braisted, John, additional, Rubin, Jeffrey S., additional, Burgess, Teresa L., additional, Farrell, Catherine L., additional, Roberts, David D., additional, and Inglese, James, additional

Published
2019
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48. Optimizing intersectoral collaboration between health and education: the Health Bridges study

Author

Burgess, Teresa, Braunack-Mayer, Annette J, Tooher, Rebecca, Collins, Joanne, O'Keefe, Michael, O'Keefe, Maree, Skinner, S R, Watson, Maureen, Ashmeade, H, Proeve, C, Marshall, Helen S, Burgess, Teresa, Braunack-Mayer, Annette J, Tooher, Rebecca, Collins, Joanne, O'Keefe, Michael, O'Keefe, Maree, Skinner, S R, Watson, Maureen, Ashmeade, H, Proeve, C, and Marshall, Helen S

Abstract

Background Schools are increasingly asked to participate in a range of public health programs, but there has been little consideration of the impact of these programs on policy and/or implementation. We investigated intersectoral collaboration between the health and education sectors using a case study of a school-based immunization program (SBIP). Methods The study was undertaken in South Australia. We undertook an ethnographic review examining health and education system functioning at a variety of levels using a mixed methods approach, informed by an interactive and multidirectional knowledge transfer framework. Results Facilitators for intersectoral collaboration included: explicit responsibilities for specific activities; clear communication channels; including the core values of each sector in planning and implementation; and collaborative development of health educational programs. Including consumers as key stakeholders in planning and implementing intersectoral programs is important. While the SBIP itself is currently successful, threats to its sustainability were identified. Conclusions Outcomes included: (i) a clearer understanding of the functioning of the SBIP in SA including wide-ranging and practical recommendations to facilitate the implementation of the program in both sectors, including revisions to enhance the experience for students; (ii) a broader outcome focusing on identification of barriers and facilitators for intersectoral collaboration and suggestions for enhancing such collaborations.

Published
2016

50. In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models

Author

Hughes, Paul E., primary, Rex, Karen, additional, Caenepeel, Sean, additional, Yang, Yajing, additional, Zhang, Yihong, additional, Broome, Martin A., additional, Kha, Hue T., additional, Burgess, Teresa L., additional, Amore, Benny, additional, Kaplan-Lefko, Paula J., additional, Moriguchi, Jodi, additional, Werner, Jonathan, additional, Damore, Michael A., additional, Baker, Daniel, additional, Choquette, Deborah M., additional, Harmange, Jean-Christophe, additional, Radinsky, Robert, additional, Kendall, Richard, additional, Dussault, Isabelle, additional, and Coxon, Angela, additional

Published
2016
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