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2. Cost-effectiveness of robotic vs laparoscopic distal pancreatectomy. Results from the national prospective trial ROBOCOSTES

Author

Guerrero-Ortiz, María Alejandra, Sánchez-Velazquez, Patricia, Burdío, Fernando, Gimeno, Marta, Podda, Mauro, Pellino, Gianluca, Toledano, Miguel, Nuñez, Javier, Bellido, Juan, Acosta-Mérida, María Asunción, Vicente, Emilio, Lopez-Ben, Santiago, Pacheco, David, Pando, Elizabeth, Jorba, Rosa, Trujillo, Juan Pablo Arjona, Ausania, Fabio, Alvarez, Mario, Fernandes, Nair, Castro-Boix, Sandra, Gantxegi, Amaia, Carré, Miquel Kraft-, Pinto-Fuentes, Pilar, Bueno-Cañones, Alejandro, Valdes-Hernandez, Javier, Tresierra, Luis, Caruso, Riccardo, Ferri, Valentina, Tio, Berta, Babiloni-Simon, Sonia, Lacasa-Martin, David, González-Abós, Carolina, Guevara-Martinez, Jenny, Gutierrez-Iscar, Eduardo, Sanchez-Santos, Raquel, Cano-Valderrama, Oscar, Nogueira-Sixto, Manuel, Alvarez-Garrido, Nicolas, Martinez-Cortijo, Sagrario, Lasaia, Manuel Alberto, Linacero, Santiago, Morante, Ana Pilar, Rotellar, Fernando, Arredondo, Jorge, Marti, Pablo, Sabatella, Lucas, Zozaya, Gabriel, and Ielpo, Benedetto

Published
2024
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3. Correction: Cost-efectiveness of robotic vs laparoscopic distal pancreatectomy. Results from the national prospective trial ROBOCOSTES

Author

Guerrero-Ortiz, María Alejandra, Sánchez-Velazquez, Patricia, Burdío, Fernando, Gimeno, Marta, Podda, Mauro, Pellino, Gianluca, Toledano, Miguel, Nuñez, Javier, Bellido, Juan, Acosta-Mérida, María Asunción, Vicente, Emilio, Lopez-Ben, Santiago, Pacheco, David, Pando, Elizabeth, Jorba, Rosa, Trujillo, Juan Pablo Arjona, Ausania, Fabio, Alvarez, Mario, Fernandes, Nair, Castro-Boix, Sandra, Gantxegi, Amaia, Carré, Miquel Kraft-, Pinto-Fuentes, Pilar, Bueno-Cañones, Alejandro, Valdes-Hernandez, Javier, Tresierra, Luis, Caruso, Riccardo, Ferri, Valentina, Tio, Berta, Babiloni-Simon, Sonia, Lacasa-Martin, David, González-Abós, Carolina, Guevara-Martinez, Jenny, Gutierrez-Iscar, Eduardo, Sanchez-Santos, Raquel, Cano-Valderrama, Oscar, Nogueira-Sixto, Manuel, Alvarez-Garrido, Nicolas, Martinez-Cortijo, Sagrario, Lasaia, Manuel Alberto, Linacero, Santiago, Morante, Ana Pilar, Rotellar, Fernando, Arredondo, Jorge, Marti, Pablo, Sabatella, Lucas, Zozaya, Gabriel, and Ielpo, Benedetto

Published
2024
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4. Focused transhepatic electroporation mediated by hypersaline infusion through the portal vein in rat model. Preliminary results on differential conductivity

Author

Pañella Clara, Castellví Quim, Moll Xavier, Quesada Rita, Villanueva Alberto, Iglesias Mar, Naranjo Dolores, Sánchez-Velázquez Patricia, Andaluz Anna, Grande Luís, Ivorra Antoni, and Burdío Fernando

Subjects
irreversible electroporation, liver tumour, electrical conductivity, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Spread hepatic tumours are not suitable for treatment either by surgery or conventional ablation methods. The aim of this study was to evaluate feasibility and safety of selectively increasing the healthy hepatic conductivity by the hypersaline infusion (HI) through the portal vein. We hypothesize this will allow simultaneous safe treatment of all nodules by irreversible electroporation (IRE) when applied in a transhepatic fashion.

Published
2017
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6. IRON: A retrospective international multicenter study on robotic versus laparoscopic versus open approach in gallbladder cancer

Author

Ielpo, Benedetto, Vittoria d’Addetta, Maria, Burdio, Fernando, Sanchez-Velazquez, Patricia, Vellalta, Gemma, Cremona, Simone, Villamonte, Maria, Morelli, Luca, Furbetta, Niccoló, Di Franco, Gregorio, Comandatore, Annalisa, Mastrangelo, Mattia, Mazzone, Chiara, Masetti, Michele, Offi, Maria Fortuna, Geraldi, Eleonora, Aldrighetti, Luca, Ingallinella, Sara, Ratti, Francesca, Rosso, Edoardo, De Blasi, Vito, Anselmo, Alessandro, Conte, Luigi Eduardo, Memeo, Riccardo, Delvecchio, Antonella, Sukandy, Iswanto, Moraldi, Luca, Grazi, Gian Luca, Spampinato, Marcello G., D'Ugo, Stefano, Heng Chiow, Adrian Kah, Yi Yee, Francis Zheng, Tan, Hiang Jin, Thiruchelvam, Nita, Lancellotti, Francesco, Satyadas, Thomas, Fedi, Massimo, De Vincenti, Rosita, Leo, Francesca, Pesi, Benedetta, Belli, Andrea, Izzo, Francesco, Cutolo, Carmen, Romano, Fabrizio, Scotti, Mauro Alessandro, Carissimi, Francesca, Garancini, Mattia, Ciulli, Cristina, Mazzola, Michele, Ferrari, Giovanni, Zironda, Andrea, Giani, Alessandro, Giuliani, Giuseppe, Federica Dorma, Maria Pia, Guerra, Francesco, Di Marino, Michele, Coratti, Andrea, Mina, Elisa, Romanzi, Andrea, Prieto, Mikel, Perfecto, Arkaitz, Ioannidis, Orestis, Lombardeas, Odysseas, Ardito, Francesco, Giuliante, Felice, Lopez-Lopez, Victor, Robles-Campos, Ricardo, Martinie, John, Mccarron, Frances, Romito, Raffaele, Nicolosi, Filadelfio Massimiliano, Ben Dhaou, Anis, Chamekh, Atef, Rezgui, Bochra, Pacilli, Mario, Pavone, Giovanna, Tartaglia, Nicola, Gupta, Rahul, Grego, Davide Giovanni, Ricci, Claudio, Pata, Francesco, Nardo, Bruno, Facundo, Helena, Guevara, Oscar, Lorenzin, Dario, Guglielmi, Alfredo, Ruzzenente, Andrea, Valle, Valentina, Alberto, Mangano, Giulianotti, PierCristoforo, Vicente, Emilio, Ferri, Valentina, Avella, Pasquale, Calise, Fulvio, Rocca, Aldo, Bianchi, Paolo, Rompianesi, Gianluca, Troisi, Roberto I., Donadon, Matteo, di Martino, Marcello, Podda, Mauro, Pisanu, Adolfo, Torzilli, Guido, Vittoria d'Addetta, Maria, Di Martino, Marcello, and Giulianotti, Pier Cristoforo

Published
2024
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7. A machine learning predictive model for recurrence of resected distal cholangiocarcinoma: Development and validation of predictive model using artificial intelligence

Author

Perez, Marc, Palnaes Hansen, Carsten, Burdio, Fernando, Sanchez-Velázquez, Patricia, Giuliani, Antonio, Lancellotti, Francesco, de Liguori-Carino, Nicola, Malleo, Giuseppe, Marchegiani, Giovanni, Podda, Mauro, Pisanu, Adolfo, De Luca, Giuseppe Massimiliano, Anselmo, Alessandro, Siragusa, Leandro, Kobbelgaard Burgdorf, Stefan, Tschuor, Christoph, Cacciaguerra, Andrea Benedetti, Koh, Ye Xin, Masuda, Yoshio, Hao Xuan, Mark Yeo, Seeger, Nico, Breitenstein, Stefan, Grochola, Filip Lukasz, Di Martino, Marcello, Secanella, Luis, Busquets, Juli, Dorcaratto, Dimitri, Mora-Oliver, Isabel, Ingallinella, Sara, Salvia, Roberto, Abu Hilal, Mohammad, Aldrighetti, Luca, and Ielpo, Benedetto

Published
2024
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9. Repeated pancreatic resection for pancreatic metastases from renal cell Carcinoma: A Spanish multicenter study (PANMEKID)

Author

Rojas-Holguín, Adela, Fondevila-Campo, Constantino, Sanjuanbenito, Alfonso, Fabregat-Prous, Joan, Secanella-Medayo, Luís, Rotellar-Sastre, Fernando, Pardo-Sánchez, Fernando, Prieto-Calvo, Mikel, Marín-Ortega, Héctor, Sánchez-Cabús, Santiago, Diez-Valladares, Luis, Alonso-Casado, Óscar, González-Serrano, Carmen, Rodríguez-Sanjuan, Juan Carlos, García-Plaza, Gabriel, Jaén-Torrejimeno, Isabel, Suárez-Muñoz, Miguel Ángel, Becerra-Massare, Antonio, Rio, Paula Senra-del, Pando, Elizabeth, López-Andújar, Rafael, Muñoz-Forner, Elena, Rodriguez-López, Mario, Pereira, Fernando, Serrablo-Requejo, Alejandro, Turrión, Víctor Sánchez, Garrido, Manuel Jiménez, Burdío, Fernando, Martín-Pérez, Elena, Estevan-Estevan, Rafael, López-Guerra, Diego, Castell-Gómez, José, Salinas-Gómez, Javier, López-Baena, José Ángel, López-Ben, Santiago, Solar-García, Lorena, Pérez-Alonso, Alejandro J., Martínez-Insfran, Luis Alberto, Blas, Juan Luis, Cornejo, Marian, Gutierrez-Calvo, Alberto, Pozo, Carlos Domingo-del, Ochando-Cerdan, Federico, Muñoz-Bellvís, Luis, Rebollar-Saenz, José, Sánchez, Belinda, Jover, José María, Gómez-Bravo, Miguel Ángel, Ramia, José M., and Blanco-Fernández, Gerardo

Published
2024
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10. Pre-operative evaluation of spontaneous portosystemic shunts as a predictor of post-hepatectomy liver failure in patients undergoing liver resection for hepatocellular carcinoma

Author

Rompianesi, Gianluca, Han, Ho-Seong, Fusai, Giuseppe, Lopez-Ben, Santiago, Maestri, Marcello, Ercolani, Giorgio, Di Martino, Marcello, Diaz-Nieto, Rafael, Ielpo, Benedetto, Perez-Alonso, Alejandro, Morare, Nolitha, Casellas, Margarida, Gallotti, Anna, de la Hoz Rodriguez, Angela, Burdio, Fernando, Ravaioli, Federico, Venetucci, Pietro, Lo Bianco, Emanuela, Ceriello, Arianna, Montalti, Roberto, and Troisi, Roberto Ivan

Published
2024
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11. Research and development of a new RF-assisted device for bloodless rapid transection of the liver: Computational modeling and in vivo experiments

Author

Subirá Jorge, Sousa Ramón, Güemes Antonio, Cruz Ignacio, Gonzalez Ana, Grande Luis, Burdío José M, Navarro Ana, Berjano Enrique J, Burdío Fernando, Castiella Tomás, Poves Ignasi, and Lequerica Juan L

Subjects
Medical technology, R855-855.5
Abstract

Abstract Background Efficient and safe transection of biological tissue in liver surgery is strongly dependent on the ability to address both parenchymal division and hemostasis simultaneously. In addition to the conventional clamp crushing or finger fracture methods other techniques based on radiofrequency (RF) currents have been extensively employed to reduce intraoperative blood loss. In this paper we present our broad research plan for a new RF-assisted device for bloodless, rapid resection of the liver. Methods Our research plan includes computer modeling and in vivo studies. Computer modeling was based on the Finite Element Method (FEM) and allowed us to estimate the distribution of electrical power deposited in the tissue, along with assessing the effect of the characteristics of the device on the temperature profiles. Studies based on in vivo pig liver models provided a comparison of the performance of the new device with other techniques (saline-linked technology) currently employed in clinical practice. Finally, the plan includes a pilot clinical trial, in which both the new device and the accessory equipment are seen to comply with all safety requirements. Results The FEM results showed a high electrical gradient around the tip of the blade, responsible for the maximal increase of temperature at that point, where temperature reached 100°C in only 3.85 s. Other hot points with lower temperatures were located at the proximal edge of the device. Additional simulations with an electrically insulated blade produced more uniform and larger lesions (assessed as the 55°C isotherm) than the electrically conducting blade. The in vivo study, in turn, showed greater transection speed (3 ± 0 and 3 ± 1 cm2/min for the new device in the open and laparoscopic approaches respectively) and also lower blood loss (70 ± 74 and 26 ± 34 mL) during transection of the liver, as compared to saline-linked technology (2 ± 1 cm2/min with P = 0.002, and 527 ± 273 mL with P = 0.001). Conclusion A new RF-assisted device for bloodless, rapid liver resection was designed, built and tested. The results demonstrate the potential advantages of this device over others currently employed.

Published
2009
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12. RF tumor ablation with internally cooled electrodes and saline infusion: what is the optimal location of the saline infusion?

Author

Cruz Ignacio, Gonzalez Ana, Subiró Jorge, Sousa Ramón, Grande Luis, Güemes Antonio, Burdío José M, Navarro Ana, Berjano Enrique J, Burdío Fernando, Castiella Tomás, Tejero Eloy, Lozano Ricardo, and de Gregorio Miguel A

Subjects
Medical technology, R855-855.5
Abstract

Abstract Background Radiofrequency ablation (RFA) of tumors by means of internally cooled electrodes (ICE) combined with interstitial infusion of saline may improve clinical results. To date, infusion has been conducted through outlets placed on the surface of the cooled electrode. However, the effect of infusion at a distance from the electrode surface is unknown. Our aim was to assess the effect of perfusion distance (PD) on the coagulation geometry and deposited power during RFA using ICE. Methods Experiments were performed on excised bovine livers. Perfusion distance (PD) was defined as the shortest distance between the infusion outlet and the surface of the ICE. We considered three values of PD: 0, 2 and 4 mm. Two sets of experiments were considered: 1) 15 ablations of 10 minutes (n ≥ 4 for each PD), in order to evaluate the effect of PD on volume and diameters of coagulation; and 2) 20 additional ablations of 20 minutes. The effect of PD on deposited power and relative frequency of uncontrolled impedance rises (roll-off) was evaluated using the results from the two sets of experiments (n ≥ 7 for each PD). Comparisons between PD were performed by analysis of variance or Kruskal-Wallis test. Additionally, non-linear regression models were performed to elucidate the best PD in terms of coagulation volume and diameter, and the occurrence of uncontrolled impedance rises. Results The best-fit least square functions were always obtained with quadratic curves where volume and diameters of coagulation were maximum for a PD of 2 mm. A thirty per cent increase in volume coagulation was observed for this PD value compared to other values (P < 0.05). Likewise, the short coagulation diameter was nearly twenty five per cent larger for a 2 mm PD than for 0 mm. Regarding deposited power, the best-fit least square function was obtained by a quadratic curve with a 2 mm PD peak. This matched well with the higher relative frequency of uncontrolled impedance rises for PD of 0 and 4 mm. Conclusion Saline perfusion at around 2 mm from the electrode surface while using an ICE in RFA improves deposition of energy and enlarges coagulation volume.

Published
2007
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14. Use and outcome of minimally invasive pancreatic surgery in the European E-MIPS registry

Author

Vilhav, Caroline, Hartman, Vera, Kirkegård, Jakob, Sergeant, Gregory, Kleeff, Jörg, Coolsen, Marielle, Coppola, Roberto, Pauletti, Bruno, Mittermair, Christof, Tingstedt, Bobby, Erkan, Mert, Tomazic, Ales, Korkolis, Dimitris, van der Heijde, Nicky, Vissers, Frederique L., Manzoni, Alberto, Zimmitti, Giuseppe, Balsells, Joaquim, Berrevoet, Frederik, Bjornsson, Bergthor, van den Boezem, Peter, Boggi, Ugo, Bratlie, Svein O., Burdio, Fernando, Coratti, Andrea, D'Hondt, Mathieu, Del Pozo, Carlos D., Dokmak, Safi, Fara, Regis, Can, Mehmet F., Festen, Sebastiaan, Forgione, Antonello, Fristrup, Claus, Gaujoux, Sebastien, Groot Koerkamp, Bas, Hackert, Thilo, Khatkov, Igor E., Keck, Tobias, Seppänen, Hanna, Lips, Daan, Luyer, Misha, Pittau, Gabriella, Maglione, Manuel, Molenaar, I. Quintus, Pessaux, Patrick, Roeyen, Geert, Saint-Marc, Olivier, Cabus, Santiago S., van Santvoort, Hjalmar, van der Schelling, George, Serradilla-Martin, Mario, Souche, Francois-regis, Suarez Muñoz, Miguel Á., Marino, Marco V., Besselink, Marc G., and Abu Hilal, Mohammed

Published
2023
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17. Pancreatic metastases from renal cell carcinoma. Postoperative outcome after surgical treatment in a Spanish multicenter study (PANMEKID)

Author

Blanco-Fernández, Gerardo, Fondevila-Campo, Constantino, Sanjuanbenito, Alfonso, Fabregat-Prous, Joan, Secanella-Medayo, Luís, Rotellar-Sastre, Fernando, Pardo-Sánchez, Fernando, Prieto-Calvo, Mikel, Marín-Ortega, Héctor, Sánchez-Cabús, Santiago, Diez-Valladares, Luis, Alonso-Casado, Óscar, González-Serrano, Carmen, Rodríguez-Sanjuan, Juan Carlos, García-Plaza, Gabriel, Jaén-Torrejimeno, Isabel, Suárez-Muñoz, Miguel Ángel, Becerra-Massare, Antonio, Rio, Paula Senra-del, Pando, Elizabeth, López-Andújar, Rafael, Muñoz-Forner, Elena, Rodriguez-López, Mario, Pereira, Fernando, Serrablo-Requejo, Alejandro, Turrión, Víctor Sánchez, Garrido, Manuel Jiménez, Burdío, Fernando, Martín-Pérez, Elena, Estevan-Estevan, Rafael, López-Guerra, Diego, Castell-Gómez, José, Salinas-Gómez, Javier, López-Baena, José Ángel, López-Ben, Santiago, Solar-García, Lorena, Pérez-Alonso, Alejandro J., Martínez-Insfran, Luis Alberto, Blas, Juan Luis, Cornejo, Marian, Gutierrez-Calvo, Alberto, Pozo, Carlos Domingo-del, Ochando-Cerdan, Federico, Muñoz-Bellvís, Luis, Rebollar-Saenz, José, Sánchez, Belinda, Jover, José María, Gómez-Bravo, Miguel Ángel, Ramia, José M., and Rojas-Holguín, Adela

Published
2022
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19. Computational modeling of radiofrequency ablation with an internally cooled wet electrode

Author

Ewertowska, Elzbieta, Quesada-Diez, Rita, Radosevic, Aleksandar, Andaluz, Anna, Moll, Xavier, Berjano, Enrique, Burdio, Fernando, Trujillo, Macarena, Magjarevic, Ratko, Editor-in-chief, Ładyżyński, Piotr, Series editor, Ibrahim, Fatimah, Series editor, Lacković, Igor, Series editor, Rock, Emilio Sacristan, Series editor, Eskola, Hannu, editor, Väisänen, Outi, editor, Viik, Jari, editor, and Hyttinen, Jari, editor

Published
2018
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25. Defining Benchmark Outcomes for Pancreatoduodenectomy With Portomesenteric Venous Resection

Author

Raptis, Dimitri A., Sánchez-Velázquez, Patricia, Machairas, Nikolaos, Sauvanet, Alain, Rueda de Leon, Alexandra, Oba, Atsushi, Groot Koerkamp, Bas, Lovasik, Brendan, Chan, Carlos, Yeo, Charles J., Bassi, Claudio, Ferrone, Cristina R., Kooby, David, Moskal, David, Tamburrino, Domenico, Yoon, Dong-Sup, Barroso, Eduardo, de Santibañes, Eduardo, Kauffmann, Emanuele F., Vigia, Emanuel, Robin, Fabien, Casciani, Fabio, Burdío, Fernando, Belfiori, Giulio, Malleo, Giuseppe, Lavu, Harish, Hartog, Hermien, Hwang, Ho Kyuong, Han, Ho-Seong, Poves, Ignasi, Rosado, Ismael Domínguez, Park, Joon-Seong, Lillemoe, Keith D., Roberts, Keith J., Sulpice, Laurent, Besselink, Marc G., Abuawwad, Mahmoud, Del Chiaro, Marco, de Santibañes, Martin, Falconi, Massimo, DʼSilva, Mizelle, Silva, Michael, Abu Hilal, Mohammed, Qadan, Motaz, Sell, Naomi M., Beghdadi, Nassiba, Napoli, Niccolò, Busch, Olivier R. C., Mazza, Oscar, Muiesan, Paolo, Müller, Philip C., Ravikumar, Reena, Schulick, Richard, Powell-Brett, Sarah, Abbas, Syed Hussain, Mackay, Tara M., Stoop, Thomas F., Gallagher, Tom K., Boggi, Ugo, van Eijck, Casper, Clavien, Pierre-Alain, Conlon, Kevin C. P., and Fusai, Giuseppe Kito

Published
2020
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27. Computational Study to Assess Whether the Heat Sink Effect of Blood Flow Inside the Portal Vein Could Thermally Protect Its Wall during RF-Assisted Resection

Author

González-Suárez, Ana, Trujillo, Macarena, Burdío, Fernando, Andaluz, Anna, Berjano, Enrique, MAGJAREVIC, Ratko, Editor-in-chief, Ładyzynsk, Piotr, Series editor, Ibrahim, Fatimah, Series editor, Lacković, Igor, Series editor, Rock, Emilio Sacristan, Series editor, and Vasic, Darko, editor

Published
2015
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40. The Impact of Neoadjuvant Treatment on Survival in Patients Undergoing Pancreatoduodenectomy With Concomitant Portomesenteric Venous Resection: An International Multicenter Analysis

Author

Machairas, Nikolaos, Raptis, Dimitri A, Velázquez, Patricia Sánchez, Sauvanet, Alain, Rueda de Leon, Alexandra, Oba, Atsushi, Koerkamp, Bas Groot, Lovasik, Brendan, Chan, Carlos, Yeo, Charles J, Bassi, Claudio, Ferrone, Cristina R, Kooby, David, Moskal, David, Tamburrino, Domenico, Yoon, Dong-Sup, Barroso, Eduardo, de Santibañes, Eduardo, Kauffmann, Emanuele F, Vigia, Emanuel, Robin, Fabien, Casciani, Fabio, Burdío, Fernando, Belfiori, Giulio, Malleo, Giuseppe, Lavu, Harish, Hartog, Hermien, Hwang, Ho-Kyoung, Han, Ho-Seong, Marques, Hugo P, et al, and University of Zurich

Subjects
610 Medicine & health, Surgery, 10217 Clinic for Visceral and Transplantation Surgery, 2746 Surgery
Published
2021

41. Towards Zero Postoperative Pancreatic Fistula After Distal Pancreatectomy: A Propensity Score Matching Analysis of Pancreatic Stump Closure With Radiofrequency Vs Stapler

Author

Périz, Eva María Pueyo, primary, Téllez-Marquès, Clara, additional, Radosevic, Alexander, additional, Morató, Olga, additional, Visa, Laura, additional, Ilzarbe, Lucas, additional, Berjano, Enrique Berjano, additional, Vicente, Emilio, additional, Poves, Ignasi, additional, Grande, Luis, additional, Burdío, Fernando, additional, and Sánchez-Velázquez, Patricia, additional

Published
2021
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43. The Impact of Neoadjuvant Treatment on Survival in Patients Undergoing Pancreatoduodenectomy With Concomitant Portomesenteric Venous Resection: An International Multicenter Analysis

Author

Machairas, Nikolaos, primary, Raptis, Dimitri A, additional, Velázquez, Patricia Sánchez, additional, Sauvanet, Alain, additional, Rueda de Leon, Alexandra, additional, Oba, Atsushi, additional, Koerkamp, Bas Groot, additional, Lovasik, Brendan, additional, Chan, Carlos, additional, Yeo, Charles J., additional, Bassi, Claudio, additional, Ferrone, Cristina R., additional, Kooby, David, additional, Moskal, David, additional, Tamburrino, Domenico, additional, Yoon, Dong-Sup, additional, Barroso, Eduardo, additional, de Santibañes, Eduardo, additional, Kauffmann, Emanuele F., additional, Vigia, Emanuel, additional, Robin, Fabien, additional, Casciani, Fabio, additional, Burdío, Fernando, additional, Belfiori, Giulio, additional, Malleo, Giuseppe, additional, Lavu, Harish, additional, Hartog, Hermien, additional, Hwang, Ho-Kyoung, additional, Han, Ho-Seong, additional, Marques, Hugo P., additional, Poves, Ignasi, additional, Domínguez-Rosado, Ismael, additional, Park, Joon-Seong, additional, Lillemoe, Keith D., additional, Roberts, Keith, additional, Sulpice, Laurent, additional, Besselink, Marc G., additional, Abuawwad, Mahmoud, additional, Del Chiaro, Marco, additional, de Santibañes, Martin, additional, Falconi, Massimo, additional, D'Silva, Mizelle, additional, Silva, Michael, additional, Hilal, Mohammed Abu, additional, Qadan, Motaz, additional, Sell, Naomi M., additional, Beghdadi, Nassiba, additional, Napoli, Niccolò, additional, Busch, Olivier R. C., additional, Mazza, Oscar, additional, Muiesan, Paolo, additional, Müller, Philip C., additional, Ravikumar, Reena, additional, Schulick, Richard, additional, Powell-Brett, Sarah, additional, Abbas, Syed Hussain, additional, Mackay, Tara M., additional, Stoop, Thomas F., additional, Gallagher, Tom K., additional, Boggi, Ugo, additional, van Eijck, Casper, additional, Clavien, Pierre-Alain, additional, Conlon, Kevin C. P., additional, and Fusai, Giuseppe Kito, additional

Published
2021
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44. Clinical case report: endoluminal thermal ablation of main pancreatic duct for patients at high risk of postoperative pancreatic fistula after pancreaticoduodenectomy

Author

Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica, AGENCIA ESTATAL DE INVESTIGACION, Agencia Estatal de Investigación, Ielpo, Benedetto, Pueyo-Périz, Eva M., Radosevic, Aleksandar, Andaluz, Anna, Berjano, Enrique, Grande, Luis, Sánchez-Velázquez, Patricia, Burdío, Fernando, Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica, AGENCIA ESTATAL DE INVESTIGACION, Agencia Estatal de Investigación, Ielpo, Benedetto, Pueyo-Périz, Eva M., Radosevic, Aleksandar, Andaluz, Anna, Berjano, Enrique, Grande, Luis, Sánchez-Velázquez, Patricia, and Burdío, Fernando

Abstract

[EN] Purpose Multiple attempts have been made to manage the pancreatic stump and the pancreatic duct in order to reduce the rate of postoperative pancreatic fistula (POPF) after pancreaticoduodenectomy (PD), however radiofrequency-based technologies could help to achieve this goal. Previous encouraging clinical and experimental results support the use of endoluminal thermal ablation (ETHA) of the main pancreatic duct to reduce pancreatic exocrine secretion and hence POPF. We here describe our initial clinical experience with ETHA of the main pancreatic duct in two cases at high risk of POPF. Methods Two cases underwent PD for malignancy with a high risk of POPF (adenocarcinoma, obese patients, surgical difficulties with heavy intraoperative blood loss, soft pancreas or walled-off pancreatitis and a tight small pancreatic main duct). In both cases, ETHA of the main pancreatic duct was conducted intraoperatively just before Blumgart-type pancreatic-jejunal anastomosis using a ClosureFast catheter (Medtronic, Mansfield, MA, USA) normally used for varicose vein treatment (therefore an off-label use). Results Although a clear radiological POPF was detected in the second case, the clinical postoperative course in both cases was uneventful. Little pancreatic fluid collected in the abdominal drainage with low levels of amylase enzyme, confirming low exocrine pancreatic function. No other procedure-related complications were detected. Conclusion Endoluminal thermal ablation of the main pancreatic duct may be a feasible and safe technique to reduce the adverse effects of POPF after PD.

Published
2021

45. Short pulsed microwave ablation: computer modeling and ex vivo experiments

Author

Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica, Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada, AGENCIA ESTATAL DE INVESTIGACION, Radosevic, Aleksandar, Prieto, Diego, Burdío, Fernando, Berjano, Enrique, Prakash, Punit, Trujillo Guillen, Macarena, Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica, Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada, AGENCIA ESTATAL DE INVESTIGACION, Radosevic, Aleksandar, Prieto, Diego, Burdío, Fernando, Berjano, Enrique, Prakash, Punit, and Trujillo Guillen, Macarena

Abstract

[EN] Purpose To study the differences between continuous and short-pulse mode microwave ablation (MWA). Methods We built a computational model for MWA including a 200 mm long and 14 G antenna from Amica-Gen and solved an electromagnetic-thermal coupled problem using COMSOL Multiphysics. We compared the coagulation zone (CZ) sizes created with pulsed and continuous modes under ex vivo and in vivo conditions. The model was used to compare long vs. short pulses, and 1000 W high-powered short pulses. Ex vivo experiments were conducted to validate the model. Results The computational models predicted the axial diameter of the CZ with an error of 2-3% and overestimated the transverse diameter by 9-11%. For short pulses, the ex vivo computer modeling results showed a trend toward larger CZ when duty cycles decreases. In general, short pulsed mode yielded higher CZ diameters and volumes than continuous mode, but the differences were not significant (<5%), as in terms of CZ sphericity. The same trends were observed in the simulations mimicking in vivo conditions. Both CZ diameter and sphericity were similar with short and long pulses. Short 1000 W pulses produced smaller sphericity and similar CZ sizes under in vivo and ex vivo conditions. Conclusions The characteristics of the CZ created by continuous and pulsed MWA show no significant differences from ex vivo experiments and computer simulations. The proposed idea of enlarging coagulation zones and improving their sphericity in pulsed mode was not evident in this study.

Published
2021

50. Defining Benchmark Outcomes for Pancreatoduodenectomy With Portomesenteric Venous Resection

Author

Raptis, Dimitri A, Sánchez-Velázquez, Patricia, Machairas, Nikolaos, Sauvanet, Alain, Rueda de Leon, Alexandra, Oba, Atsushi, Groot Koerkamp, Bas, Lovasik, Brendan, Chan, Carlos, Yeo, Charles J, Bassi, Claudio, Ferrone, Cristina R, Kooby, David, Moskal, David, Tamburrino, Domenico, Yoon, Dong-Sup, Barroso, Eduardo, de Santibañes, Eduardo, Kauffmann, Emanuele F, Vigia, Emanuel, Robin, Fabien, Casciani, Fabio, Burdío, Fernando, Belfiori, Giulio, Malleo, Giuseppe, Lavu, Harish, Hartog, Hermien, Hwang, Ho Kyuong, Han, Ho-Seong, Poves, Ignasi, et al, and University of Zurich

Subjects
610 Medicine & health, Surgery, 10217 Clinic for Visceral and Transplantation Surgery, 2746 Surgery
Published
2020
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