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4. Endothelial dysfunction and pulmonary hypertension

Author

Burchenal, J.E.B. and Loscalzo, Joseph

Subjects
Pulmonary hypertension -- Causes of, Vascular endothelium -- Abnormalities, Health
Abstract

Pulmonary hypertension is associated with a variety of underlying disorders. Either as a cause or a consequence of increasing pulmonary pressure, the pulmonary vascular endothelium is believed to behave abnormally in persons with this disorder Evidence suggests that a relationship exists between endothelial dysfunction and pulmonary hypertension.

Published
1994

13. Coronary Angioplasty.

Author

Green NE, Maddux JT, and Burchenal JE

Abstract

Percutaneous revascularization is a widely accepted procedure to treat patients with coronary artery disease. Since its first description in the 1970s, significant technological and pharmaceutical advances have occurred and subsequently reduced the complications associated with the procedure. Large, randomized controlled trials have provided additional evidence that percutaneous revascularization improves morbidity and mortality in patients with coronary artery disease. Over the last decade, devices designed to treat patients with more complex coronary artery disease have expanded the available therapeutic options and will likely contribute to a further decline in adverse events. Despite these advances, the management of patients with acute myocardial infarction, in-stent restenosis, and multivessel coronary artery disease remains challenging. The majority of evidence supports an early, aggressive approach in patients with acute ST-elevation and non-ST-elevation myocardial infarction. Ongoing clinical trials should help to further define the role of percutaneous interventions in the optimal management of patients with coronary artery disease.

Published
2003
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