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2. Lactobacillus brevis CD2 for Prevention of Oral Mucositis in Patients With Head and Neck Tumors: A Multicentric Randomized Study.

Author

DE Sanctis V, Belgioia L, Cante D, LA Porta MR, Caspiani O, Guarnaccia R, Argenone A, Muto P, Musio D, DE Felice F, Maurizi F, Bunkhelia F, Ruo Redda MG, Reali A, Valeriani M, Osti MF, Alterio D, Bacigalupo A, and Russi EG

Subjects
Administration, Oral, Adult, Aged, Female, Head and Neck Neoplasms diagnosis, Humans, Italy, Male, Middle Aged, Mouthwashes adverse effects, Prospective Studies, Saliva microbiology, Sodium Bicarbonate adverse effects, Stomatitis diagnosis, Stomatitis microbiology, Time Factors, Treatment Outcome, Chemoradiotherapy adverse effects, Head and Neck Neoplasms therapy, Levilactobacillus brevis physiology, Mouth microbiology, Mouthwashes administration & dosage, Probiotics administration & dosage, Sodium Bicarbonate administration & dosage, Stomatitis prevention & control
Abstract

Background: Oropharyngeal mucositis occurs in virtually all patients with head and neck cancer receiving radiochemotherapy. The manipulation of the oral cavity microbiota represents an intriguing and challenging target., Patients and Methods: A total of 75 patients were enrolled to receive Lactobacillus brevis CD2 lozenges or oral care regimen with sodium bicarbonate mouthwashes. The primary endpoint was the incidence of grade 3 or 4 oropharyngeal mucositis during radiotherapy treatment., Results: There was no statistical difference in the incidence of grade 3-4 oropharyngeal mucositis between the intervention and control groups (40.6% vs. 41.6% respectively, p=0.974). The incidence of pain, dysphagia, body weight loss and quality of life were not different between the experimental and standard arm., Conclusion: Our study was not able to demonstrate the efficacy of L. brevis CD2 lozenges in preventing radiation-induced mucositis in patients with head and neck cancer. Although modulating homeostasis of the salivary microbiota in the oral cavity seems attractive, it clearly needs further study., (Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Published
2019
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