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4. Native left atrial tachycardias clinical and electrophysiological characteristics: Insights from a National survey.

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Bun, S.-S., Even, J., Lellouche, N., Waldmann, V., Marijon, E., Taghji, P., Deharo, J.C., Moceri, P., Scarlatti, D., Squara, F., Charton, J., de Guillebon, M., Maluski, A., Garret, G., and Ferrari, E.

Abstract

Native left atrial tachycardias (ATs), — in the absence of atriotomy or previous left atrial (LA) ablations — are rare observations. We aimed to analyze the clinical and electrophysiological characteristics of native left ATs from a National survey, especially the occurrence of atrial fibrillation (AF) in these patients during the follow-up. From Jan 2023 to Dec 2023, a questionnaire was electronically sent to French electrophysiologists in order to analyze the characteristics of native left ATs. Patients with previous history of AF, and/or previous atriotomy, and/or previous LA ablation were excluded from this study. 39 patients were included (Fig. 1): 71 ± 10 years; male 66.7%, structural heart disease 61.5%. The culprit circuit was localized in 30.7% and macroreentrant in 61.5% of the cases, around an anterior scar present in 53.8%. The initial ablation strategy consisted in pulmonary vein isolation in the majority of the cases (23/39), and LA lines creation in 30/39 (76.9%). Initial ablation procedure was considered successful in all. 8/39 (20.5%) patients underwent a second procedure. After a mean follow-up of 21 ± 22 months, 13/39 (33.4%) patients presented AT recurrences with infrequent AF recurrence (1 patient out of 39). In this specific group of patients with native left ATs, ablation strategy is associated with a high acute success rate, with 33% AT recurrences during the follow-up, but without significant AF recurrences. [ABSTRACT FROM AUTHOR]

Published
2025
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24. Poster Session 3

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Fabbri, G. M. 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A., additional, Iitsuka, K., additional, Kondo, T., additional, Goebbert, K., additional, Karossiene, Z., additional, Goldman, D., additional, Kallen, B., additional, Kerpi, E., additional, Sardo, J., additional, Arsenos, P., additional, Gatzoulis, K., additional, Manis, G., additional, Dilaveris, P., additional, Tsiachris, D., additional, Mytas, D., additional, Asimakopoulos, S., additional, Stefanadis, C., additional, Sideris, S., additional, Kartsagoulis, E., additional, Barbosa, O., additional, Marocolo Junior, M., additional, Silva Cortes, R., additional, Moraes Brandolis, R. A., additional, Oliveira, L. F., additional, Pertili Rodrigues De Resende, L. A., additional, Vieira Da Silva, M. A., additional, Dias Da Silva, V. J., additional, Hegazy, R. A., additional, Sharaf, I. A., additional, Fadel, F., additional, Bazaraa, H., additional, Esam, R., additional, Deshko, M. S., additional, Snezhitsky, V. A., additional, Stempen, T. P., additional, Kuroki, K., additional, Igawa, M., additional, Kuga, K., additional, Ferreira Santos, L., additional, Dionisio, T., additional, Nunes, L., additional, Machado, J., additional, Castedo, S., additional, Henriques, C., additional, Matos, A., additional, Oliveira Santos, J., additional, Kraaier, K., additional, Olimulder, M. A. G. M., additional, Galjee, M. A., additional, Van Dessel, P. F. H. M., additional, Van Der Palen, J., additional, Wilde, A. A. M., additional, Scholten, M. F., additional, Chouchou, F., additional, Poupard, L., additional, Philippe, C., additional, Court-Fortune, I., additional, Barthelemy, J.- C., additional, Roche, F., additional, Dolgoshey, T. S., additional, Madekina, G. 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Published
2011
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29. Effect of green tea extracts on liver functions in Wistar rats.

Author

Bun SS, Bun H, Guédon D, Rosier C, and Ollivier E

Subjects
Animals, Chemical and Drug Induced Liver Injury enzymology, Enzymes blood, Female, Liver Function Tests, Plant Extracts chemistry, Plant Extracts pharmacology, Rats, Rats, Wistar, Liver drug effects, Tea chemistry
Abstract

An herbal medicinal product (Exolise) containing as active ingredient an hydro-alcoholic extract of green tea named AR25 (standardized to 25% catechins) has been implicated in hepatic failures, leading to the withdrawal of the marketing authorization. The active ingredient of Exolise being manufactured with 80% ethanol, the question to know whether the extraction solvent could introduce some toxic components was hypothesized. Two investigations were conducted in Wistar rats to determine if repeated oral administration of different green tea extracts could corroborate the reported hepatotoxicity in humans. In a preliminary 6 week-study, experimental groups (n=9/group) received either the vehicle or a methylene chloride extract (2500 mg/kg body weight) where potential non-polar hepatotoxin(s) could be concentrated. In a second experiment (12 week-study), rats were divided in three groups (n=10/group) and treated with either the vehicle, or an aqueous extract (1400 mg/kg) or AR25 green tea extract (2000 mg/kg). Rat liver functions were assessed by serum biochemistry of hepatotoxicity markers. No sign of evidence of characteristic hepatotoxicity was found in rats treated with very high amount of different green tea extracts in these two experiments (respectively a daily dosage, which was about 900 and 80 times higher to the therapeutic daily dosage of Exolise.

Published
2006
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30. Drug interactions of paclitaxel metabolism in human liver microsomes.

Author

Bun SS, Ciccolini J, Bun H, Aubert C, and Catalin J

Subjects
Adult, Biological Availability, Cells, Cultured, Chromatography, High Pressure Liquid, Dose-Response Relationship, Drug, Drug Interactions, Female, Humans, Male, Observer Variation, Sensitivity and Specificity, Antineoplastic Agents metabolism, Antineoplastic Agents pharmacology, Microsomes, Liver drug effects, Paclitaxel metabolism, Paclitaxel pharmacology
Abstract

The human liver metabolism of paclitaxel (Taxol), an anticancer drug, leads to three metabolites: 6alpha-hydroxypaclitaxel, 3'-p-hydroxypaclitaxel and 6alpha,3'-p-dihydroxypaclitaxel. The inter-individual variability of paclitaxel metabolism was investigated first in vitro using 22 human liver microsomes. Three metabolites have been detected by HPLC. This preliminary work revealed marked inter-individual differences in paclitaxel metabolism. The amount of major metabolite 6alpha-hydroxypaclitaxel formed varied 16-fold (0.7 to 11.5 nmol/mg/h). We next studied the effect of 29 compounds (antineoplastics, antiemetics, histamine-2 receptor antagonist, antalgics, antifungals, antivirals, psychotropics, antibiotic, corticoid, antiarrhythmic, calcium channel blocker) on paclitaxel metabolism in human liver microsomes. Among the compounds studied, quercetin, antifungal drugs such as ketoconazole and miconazole, and the antineoplastic drug doxorubicin inhibited formation of 6alpha-hydroxypaclitaxel. Dixon plots indicated that quercetin and doxorubicin inhibited 6alpha-hydroxypaclitaxel formation through a competitive mechanism with a Ki of 10.1 microM and 64.8 microM, respectively. The inhibition of this metabolite by ketoconazole was through a noncompetitive mechanism with a Ki of 11.8 microM. Our data thus suggest that special attention should be paid when these drugs are combined in clinical practice.

Published
2003
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