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We report on X-ray (NICER/NuSTAR/MAXI/Swift) and radio (MeerKAT) timing and spectroscopic analysis from a three-month monitoring campaign in 2022 of a high-intensity outburst of the dipping neutron star low-mass X-ray binary 1A 1744-361. The 0.5-6.8 keV NICER X-ray hardness-intensity and color-color diagrams of the observations throughout the outburst suggests that 1A 1744-361 spent most of its outburst in an atoll-state, but we show that the source exhibited Z-state-like properties at the peak of the outburst, similar to a small sample of other atoll-state sources. A timing analysis with NICER data revealed several instances of an $\approx8$ Hz quasi-periodic oscillation (QPO; fractional rms amplitudes of ~5%) around the peak of the outburst, the first from this source, which we connect to the normal branch QPOs (NBOs) seen in the Z-state. Our observations of 1A 1744-361 are fully consistent with the idea of the mass accretion rate being the main distinguishing parameter between atoll- and Z-states. Radio monitoring data by MeerKAT suggests that the source was at its radio-brightest during the outburst peak, and that the source transitioned from the 'island' spectral state to the 'banana' state within ~3 days of the outburst onset, launching transient jet ejecta. The observations present the strongest evidence for radio flaring, including jet ejecta, during the island-to-banana spectral state transition at low accretion rates (atoll-state). The source also exhibited Fe XXV, Fe XXVI K$\alpha$, and K$\beta$ X-ray absorption lines, whose origins likely lie in an accretion disk atmosphere., Comment: 30 pages, 13 figures, and 8 tables. Accepted by ApJ (before proofs)

We present temporal and time-resolved spectral analyses of all the thermonuclear X-ray bursts observed from the neutron star low-mass X-ray binary (LMXB) 4U 1728-34 with NICER from June 2017 to September 2019. In total, we detected 11 X-ray bursts from the source and performed time-resolved spectroscopy. Unlike some of the earlier results for other bursting sources from NICER, our spectral results indicate that the use of a scaling factor for the persistent emission is not statistically necessary. This is primarily a result of the strong interstellar absorption in the line of sight towards 4U 1728-34, which causes the count rates to be significantly lower at low energies. We also searched for burst oscillations and detected modulations in six different bursts at around the previously known burst oscillation frequency of 363 Hz. Finally, we report the detection of oscillations prior to two bursts at 356 and 359 Hz, respectively. This is the first time in the literature where burst oscillations are detected before the rapid rise in X-ray flux, from any known burster. These oscillations disappear as soon as the burst rise starts and occur at a somewhat lower frequency than the oscillations we detect during the bursts., Comment: Accepted for publication in the Astrophysical Journal

Multiplexed Assays of Variant Effect (MAVEs) have emerged as a powerful approach for interrogating thousands of genetic variants in a single experiment. The flexibility and widespread adoption of these techniques across diverse disciplines has led to a heterogeneous mix of data formats and descriptions, which complicates the downstream use of the resulting datasets. To address these issues and promote reproducibility and reuse of MAVE data, we define a set of minimum information standards for MAVE data and metadata and outline a controlled vocabulary aligned with established biomedical ontologies for describing these experimental designs.

Swift J1749.4-2807 is the only known eclipsing accreting millisecond X-ray pulsar. In this paper, we report on 7 thermonuclear (Type-I) X-ray bursts observed by NICER during its 2021 outburst. The first 6 bursts show slow rises and long decays, indicative of mixed H/He fuel, whereas the last burst shows fast rise and decay, suggesting He-rich fuel. Time-resolved spectroscopy of the bursts revealed typical phenomenology (i.e., an increase in black body temperature during the burst rise, and steady decrease in the decay), however they required a variable $N_\mathrm{H}$. We found that the values of $N_\mathrm{H}$ during the bursts were roughly double those found in the fits of the persistent emission prior to each burst. We interpret this change in absorption as evidence of burst-disc interaction, which we observe due to the high inclination of the system. We searched for burst oscillations during each burst and detected a signal in the first burst at the known spin frequency of the neutron star (517.92 Hz). This is the first time burst oscillations have been detected from Swift J1749.4-2807. We further find that each X-ray burst occurs on top of an elevated persistent count rate. We performed time-resolved spectroscopy on the combined data of the bursts with sufficient statistics (i.e., the clearest examples of this phenomenon) and found that the black body parameters evolve to hotter temperatures closer to the onset of the bursts. We interpret this as a consequence of an unusual marginally stable burning process similar to that seen through mHz QPOs., Comment: accepted for publication in MNRAS, 12 pages, 11 figures

We report the discovery of millihertz quasi-periodic oscillations (mHz QPOs) from the neutron star (NS) low-mass X-ray binary 4U 1730--22 using the Neutron Star Interior Composition Explorer (NICER). After being inactive for almost 50 years, 4U 1730--22 went into outburst twice between June and August 2021, and between February and July 2022. We analyse all the NICER observations of this source, and detect mHz QPOs with a significance > $4\sigma$ in 35 observations. The QPO frequency of the full data set ranged between ~4.5 and ~8.1 mHz with an average fractional rms amplitude of the order of ~2%. The X-ray colour analysis strongly suggests that 4U 1730--22 was in a soft spectral state during the QPO detections. Our findings are consistent with those reported for other sources where the mHz QPOs have been interpreted as the result of a special mode of He burning on the NS surface called marginally stable nuclear burning (MSNB). We conclude that the mHz QPOs reported in this work are also associated with the MSNB, making 4U 1730--22 the eighth source that shows this phenomenology. We discuss our findings in the context of the heat flux from the NS crust., Comment: 9 pages, 6 figures. Accepted for publication in MNRAS

We present a study of weak, thermonuclear X-ray bursts from the accreting millisecond X-ray pulsar SAX J1808.4-3658. We focus on a burst observed with the Neutron Star Interior Composition Explorer on 2019 August 9, and describe a similar burst observed with the Rossi X-ray Timing Explorer in 2005 June. These bursts occurred soon after outburst onset, $2.9$ and $1.1$ days, after the first indications of fresh accretion. We measure peak burst bolometric fluxes of $6.98 \pm 0.50 \times 10^{-9}$ and $1.54 \pm 0.10 \times 10^{-8}$ erg cm$^{-2}$ s$^{-1}$, respectively, which are factors of $\approx 30$ and $15$ less than the peak flux of the brightest, helium-powered bursts observed from this source. From spectral modeling we estimate accretion rates and accreted columns at the time of each burst. For the 2019 burst we estimate an accretion rate of $\dot M \approx 1.4-1.6 \times 10^{-10}$ $M_{\odot}$ yr$^{-1}$, and a column in the range $3.9-5.1 \times 10^7$ g cm$^{-2}$. For the 2005 event the accretion rate was similar, but the accreted column was half of that estimated for the 2019 burst. The low accretion rates, modest columns, and evidence for a cool neutron star in quiescence, suggest these bursts are triggered by thermally unstable CNO cycle hydrogen-burning. The post-burst flux level in the 2019 event appears offset from the pre-burst level by an amount consistent with quasi-stable hydrogen-burning due to the temperature-insensitive, hot-CNO cycle, further suggesting hydrogen-burning as the primary fuel source. This provides strong observational evidence for hydrogen-triggered bursts. We discuss our results in the context of previous theoretical modeling., Comment: 14 pages, 6 figures, 2 tables

We present a pulse timing analysis of NICER observations of the accreting millisecond X-ray pulsar SAX J1808.4$-$3658 during the outburst that started on 2022 August 19. Similar to previous outbursts, after decaying from a peak luminosity of $\simeq 1\times10^{36} \, \mathrm{erg \, s^{-1}}$ in about a week, the pulsar entered in a $\sim 1$ month-long reflaring stage. Comparison of the average pulsar spin frequency during the outburst with those previously measured confirmed the long-term spin derivative of $\dot{\nu}_{\textrm{SD}}=-(1.15\pm0.06)\times 10^{-15} \, \mathrm{Hz\,s^{-1}}$, compatible with the spin-down torque of a $\approx 10^{26} \, \mathrm{G \, cm^3}$ rotating magnetic dipole. For the first time in the last twenty years, the orbital phase evolution shows evidence for a decrease of the orbital period. The long-term behaviour of the orbit is dominated by a $\sim 11 \, \mathrm{s}$ modulation of the orbital phase epoch consistent with a $\sim 21 \, \mathrm{yr}$ period. We discuss the observed evolution in terms of a coupling between the orbit and variations in the mass quadrupole of the companion star., Comment: 11 pages, 3 figures, 1 table. Accepted for publication in ApJ Letters

We present observations of the historic transient 4U 1730-22 as observed with the Neutron Star Interior Composition Explorer (NICER). After remaining in quiescence since its 1972 discovery, this X-ray binary showed renewed outburst activity in 2021 and 2022. We observed 4U 1730-22 extensively with NICER, detecting a total of 17 thermonuclear X-ray bursts. From a spectroscopic analysis, we find that these X-ray bursts can be divided into a group of bright and weak bursts. All bright bursts showed $1\sim2$ second rise times and a photospheric radius expansion phase, while the weak bursts showed a slower $\sim5$ second rise with a tendency for concave shapes. From the photospheric radius expansion flux, we estimate the source distance at $6.9\pm0.2$ kpc. We consider various interpretations for our observations and suggest that they may be explained if accreted material is burning stably at the stellar equator, and unstable ignition occurs at a range of higher latitudes., Comment: 13 pages, 6 figures, 2 tables. Accepted for publication in ApJ

The detection of coherent X-ray pulsations at ~314 Hz (3.2 ms) classifies MAXI J1957+032 as a fast-rotating, accreting neutron star. We present the temporal and spectral analysis performed using NICER observations collected during the latest outburst of the source. Doppler modulation of the X-ray pulsation revealed the ultra-compact nature of the binary system characterised by an orbital period of ~1 hour and a projected semi-major axis of 14 lt-ms. The neutron star binary mass function suggests a minimum donor mass of 1.7e-2 Msun, assuming a neutron star mass of 1.4 Msun and a binary inclination angle lower than 60 degrees. This assumption is supported by the lack of eclipses or dips in the X-ray light curve of the source. We characterised the 0.5-10 keV energy spectrum of the source in outburst as the superposition of a relatively cold black-body-like thermal emission compatible with the emission from the neutron star surface and a Comptonisation component with photon index consistent with a typical hard state. We did not find evidence for iron K-alpha lines or reflection components., Comment: 5 pages, 4 figures. Accepted for publication in MNRAS

We present the discovery of 528.6 Hz pulsations in the new X-ray transient MAXI J1816-195. Using NICER, we observed the first recorded transient outburst from the neutron star low-mass X-ray binary MAXI J1816-195 over a period of 28 days. From a timing analysis of the 528.6 Hz pulsations, we find that the binary system is well described as a circular orbit with an orbital period of 4.8 hours and a projected semi-major axis of 0.26 light-seconds for the pulsar, which constrains the mass of the donor star to $0.10-0.55 M_\odot$. Additionally, we observed 15 thermonuclear X-ray bursts showing a gradual evolution in morphology over time, and a recurrence time as short as 1.4 hours. We did not detect evidence for photospheric radius expansion, placing an upper limit on the source distance of 8.6 kpc., Comment: 8 pages, 3 figures, 2 tables. Accepted for publication in ApJ Letters

The neutron star low-mass X-ray binary SWIFT J1749.4-2807 is the only known eclipsing accreting millisecond X-ray pulsar. In this manuscript we perform a spectral characterization of the system throughout its 2021, two-week-long outburst, analyzing 11 NICER observations and quasi-simultaneous XMM-Newton and NuSTAR single observations at the outburst peak. The broadband spectrum is well-modeled with a black body component with a temperature of $\sim$0.6 keV, most likely consistent with a hot spot on the neutron star surface, and a Comptonisation spectrum with power-law index $\Gamma \sim 1.9$, arising from a hot corona at $\sim$12 keV. No direct emission from the disc was found, possibly due to it being too cool. A high truncation radius for the disc, i.e., at $\sim$20--30 R$_{G}$ , was obtained from the analysis of the broadened profile of the Fe line in the reflection component. The significant detection of a blue-shifted Fe XXVI absorption line at $\sim$7 keV indicates weakly relativistic X-ray disc winds, which are typically absent in the hard state of X-ray binaries. By comparing the low flux observed during the outburst and the one expected in a conservative mass-transfer, we conclude that mass-transfer in the system is highly non-conservative, as also suggested by the wind detection. Finally, using the Nicer spectra alone, we followed the system while it was fading to quiescence. During the outburst decay, as the spectral shape hardened, the hot spot on the neutron star surface cooled down and shrank, a trend which could be consistent with the pure power-law spectrum observed during quiescence., Comment: 15 pages, 9 figure; accepted for publication on MNRAS

We present the detection of 51 thermonuclear X-ray bursts observed from 4U 1636-536 by the Neutron Star Interior Composition Explorer (NICER) over the course of a three year monitoring campaign. We performed time resolved spectroscopy for 40 of these bursts and showed the existence of a strong soft excess in all the burst spectra. The excess emission can be characterized by the use of a scaling factor (f_a method) to the persistent emission of the source, which is attributed to the increased mass accretion rate on to the neutron star due to Poynting-Robertson drag. The soft excess emission can also be characterized by the use of a model taking into account the reflection of the burst emission off of the accretion disk. We also present time resolved spectral analysis of 5 X-ray bursts simultaneously observed by NICER and AstroSat, which confirm the main results with even greater precision. Finally, we present evidence for Compton cooling using 7 X-ray bursts observed contemporaneously with \nustar, by means of a correlated decrease in the hard X-ray lightcurve of 4U 1636-536 as the bursts start., Comment: Accepted for publication in the Astrophysical Journal

We present the pulsar timing analysis of the accreting millisecond X-ray pulsar SWIFT J1749.4-2807 monitored by NICER and XMM-Newton during its latest outburst after almost eleven years of quiescence. From the coherent timing analysis of the pulse profiles, we updated the orbital ephemerides of the system. Large phase jumps of the fundamental frequency phase of the signal are visible during the outburst, consistent with what was observed during the previous outburst. Moreover, we report on the marginally significant evidence for non-zero eccentricity ($e\simeq 4\times 10^{-5}$) obtained independently from the analysis of both the 2021 and 2010 outbursts and we discuss possible compatible scenarios. Long-term orbital evolution of SWIFT J1749.4-2807 suggests a fast expansion of both the NS projected semi-major axis $(x)$, and the orbital period $(P_{\rm orb})$, at a rate of $\dot{x}\simeq 2.6\times 10^{-13}\,\text{lt-s}\,\text{s}^{-1}$ and $\dot{P}_{\rm orb}\simeq 4 \times 10^{-10}\,\text{s}\,\text{s}^{-1}$, respectively. SWIFT J1749.4-2807 is the only accreting millisecond X-ray pulsar, so far, from which the orbital period derivative has been directly measured from appreciable changes on the observed orbital period. Finally, no significant secular deceleration of the spin frequency of the compact object is detected, which allowed us to set a constraint on the magnetic field strength at the polar caps of $B_{PC}<1.3\times 10^{8}~\text{G}$, in line with typical values reported for AMXPs., Comment: 13 pages, 3 figures, 1 table. Accepted for publication in MNRAS

The brightest Fast Blue Optical Transients (FBOTs) are mysterious extragalactic explosions that may represent a new class of astrophysical phenomena. Their fast time to maximum brightness of less than a week and decline over several months and atypical optical spectra and evolution are difficult to explain within the context of core-collapse of massive stars which are powered by radioactive decay of Nickel-56 and evolve more slowly. AT2018cow (at redshift of 0.014) is an extreme FBOT in terms of rapid evolution and high luminosities. Here we present evidence for a high-amplitude quasi-periodic oscillation (QPO) of AT2018cow's soft X-rays with a frequency of 224 Hz (at 3.7$\sigma$ significance level or false alarm probability of 0.02%) and fractional root-mean-squared amplitude of >30%. This signal is found in the average power density spectrum taken over the entire 60-day outburst and suggests a highly persistent signal that lasts for a billion cycles. The high frequency (rapid timescale) of 224 Hz (4.4 ms) argues for a compact object in AT2018cow, which can be a neutron star or black hole with a mass less than 850 solar masses. If the QPO is the spin period of a neutron star, we can set limits on the star's magnetic field strength. Our work highlights a new way of using high time-resolution X-ray observations to study FBOTs., Comment: Published in Nature astronomy on 13th December 2021

We present spectral and temporal properties of all the thermonuclear X-ray bursts observed from Aql X-1 by the Neutron Star Interior and Composition Explorer (NICER) between 2017 July and 2021 April. This is the first systematic investigation of a large sample of type I X-ray bursts from Aql X-1 with improved sensitivity at low energies. We detect 22 X-ray bursts including two short recurrence burst events in which the separation was only 451 s and 496 s. We perform time resolved spectroscopy of the bursts using the fixed and scaled background (f_a method) approaches. We show that the use of a scaling factor to the pre-burst emission is the statistically preferred model in about 68% of all the spectra compared to the fixed background approach. Typically the f_a values are clustered around 1-3, but can reach up to 11 in a burst where photospheric radius expansion is observed. Such f_a values indicate a very significant increase in the pre-burst emission especially at around the peak flux moments of the bursts. We show that the use of the f_a factor alters the best fit spectral parameters of the burst emission. Finally, we employed a reflection model instead of scaling the pre-burst emission. We show that reflection models also do fit the spectra and improve the goodness of the fits. In all cases we see that the disc is highly ionized by the burst emission and the fraction of the reprocessed emission to the incident burst flux is typically clustered around 20%., Comment: Accepted for publication in Monthly Notices of the Royal Astronomical Society

Results are presented of searches for continuous gravitational waves from 20 accreting millisecond X-ray pulsars with accurately measured spin frequencies and orbital parameters, using data from the third observing run of the Advanced LIGO and Advanced Virgo detectors. The search algorithm uses a hidden Markov model, where the transition probabilities allow the frequency to wander according to an unbiased random walk, while the $\mathcal{J}$-statistic maximum-likelihood matched filter tracks the binary orbital phase. Three narrow sub-bands are searched for each target, centered on harmonics of the measured spin frequency. The search yields 16 candidates, consistent with a false alarm probability of 30% per sub-band and target searched. These candidates, along with one candidate from an additional target-of-opportunity search done for SAX J1808.4$-$3658, which was in outburst during one month of the observing run, cannot be confidently associated with a known noise source. Additional follow-up does not provide convincing evidence that any are a true astrophysical signal. When all candidates are assumed non-astrophysical, upper limits are set on the maximum wave strain detectable at 95% confidence, $h_0^{95\%}$. The strictest constraint is $h_0^{95\%} = 4.7\times 10^{-26}$ from IGR J17062$-$6143. Constraints on the detectable wave strain from each target lead to constraints on neutron star ellipticity and $r$-mode amplitude, the strictest of which are $\epsilon^{95\%} = 3.1\times 10^{-7}$ and $\alpha^{95\%} = 1.8\times 10^{-5}$ respectively. This analysis is the most comprehensive and sensitive search of continuous gravitational waves from accreting millisecond X-ray pulsars to date., Comment: 40 pages, 6 figures. This version contains minor typographical revisions to match published article

This work presents an investigation of the stochastic X-ray variability from the 164 Hz accreting millisecond pulsar IGR J17062-6143, based on regular observations collected with the Neutron Star Interior Composition Explorer between 2017 July and 2020 August. Over this period, the power density spectrum showed a stable morphology, with broad $\sim25\%$ rms band-limited noise below 16 Hz. Quasi-periodic oscillations (QPOs) were occasionally observed, with the most notably detections including a low-frequency QPO centered at 2.7 Hz and a sharp QPO centered at 115 Hz that may be a 2:3 resonance with the spin frequency. Further, the energy dependence of the band-limited noise is studied through a spectroscopic analysis of the complex covariance in two frequency intervals. It is found that the power law continuum is the primary driver for the observed variability, although the thermal (blackbody) emission also appears to be intrinsically variable in area ($5\%$ rms) and temperature ($1\%$ rms). Notably, the 1 keV emission feature seen in all X-ray spectra of IGR J17062-6143 varies with the same amplitude as the power law, but systematically lags behind that continuum emission. These results appear consistent with a scenario in which a time variable Compton-scattering corona is the primary source for the observed stochastic variability, with the variability observed in the emission feature and at the lowest photon energies being due to the disk reflection of the power law continuum., Comment: 13 pages, 5 figures, 3 tables. Accepted for publication in ApJ

We report on a spectroscopic analysis of the X-ray emission from IGR J17062-6143 in the aftermath of its June 2020 intermediate duration Type I X-ray burst. Using the Neutron Star Interior Composition Explorer, we started observing the source three hours after the burst was detected with MAXI/GSC, and monitored the source for the subsequent twelve days. We observed the tail end of the X-ray burst cooling phase, and find that the X-ray flux is severely depressed relative to its historic value for a three day period directly following the burst. We interpret this intensity dip as the inner accretion disk gradually restoring itself after being perturbed by the burst irradiation. Superimposed on this trend we observed a $1.5$ d interval during which the X-ray flux is sharply lower than the wider trend. This drop in flux could be isolated to the non-thermal components in the energy spectrum, suggesting that it may be caused by an evolving corona. Additionally, we detected a 3.4 keV absorption line at $6.3\sigma$ significance in a single $472$ s observation while the burst emission was still bright. We tentatively identify the line as a gravitationally redshifted absorption line from burning ashes on the stellar surface, possibly associated with ${}^{40}{\rm Ca}$ or ${}^{44}{\rm Ti}$., Comment: 14 pages, 7 figures, 3 tables. Accepted for publication in ApJ

We present the discovery of eclipses in the X-ray light curves of the X-ray binary Swift J1858.6-0814. From these, we find an orbital period of $P=76841.3_{-1.4}^{+1.3}$ s ($\approx21.3$ hours) and an eclipse duration of $t_{\rm ec}=4098_{-18}^{+17}$ s ($\approx1.14$ hours). We also find several absorption dips during the pre-eclipse phase. From the eclipse duration to orbital period ratio, the inclination of the binary orbit is constrained to $i>70^\circ$. The most likely range for the companion mass suggests that the inclination is likely to be closer to this value than $90^\circ$. The eclipses are also consistent with earlier data, in which strong variability ('flares') and the long orbital period prevent clear detection of the period or eclipses. We also find that the bright flares occurred preferentially in the post-eclipse phase of the orbit, likely due to increased thickness at the disc-accretion stream interface preventing flares being visible during the pre-eclipse phase. This supports the notion that variable obscuration is responsible for the unusually strong variability in Swift J1858.6-0814., Comment: 12 pages, 11 figures, MNRAS accepted

We report on a coherent timing analysis of the 163 Hz accreting millisecond X-ray pulsar IGR J17062-6143. Using data collected with the Neutron Star Interior Composition Explorer and XMM-Newton, we investigated the pulsar evolution over a timespan of four years. We obtained a unique phase-coherent timing solution for the stellar spin, finding the source to be spinning up at a rate of $(3.77\pm0.09)\times 10^{-15}$ Hz/s. We further find that the $0.4-6$ keV pulse fraction varies gradually between 0.5% and 2.5% following a sinusoidal oscillation with a $1210\pm40$ day period. Finally, we supplemented this analysis with an archival Rossi X-ray Timing Explorer observation, and obtained a phase coherent model for the binary orbit spanning 12 years, yielding an orbital period derivative measurement of $(8.4\pm2.0) \times 10^{-12}$ s/s. This large orbital period derivative is inconsistent with a binary evolution that is dominated by gravitational wave emission, and is suggestive of highly non-conservative mass transfer in the binary system., Comment: 16 pages, 7 figures, 5 tables. Accepted for publication in ApJ

We introduce a method to estimate continuum percolation thresholds and illustrate its usefulness by investigating geometric percolation of non-interacting line segments and disks in two spatial dimensions. These examples serve as models for electrical percolation of elongated and flat nanofillers in thin film composites. While the standard contact volume argument and extensions thereof in connectedness percolation theory yield accurate predictions for slender nanofillers in three dimensions, they fail to do so in two dimensions, making our test a stringent one. In fact, neither a systematic order-by-order correction to the standard argument nor invoking the connectedness version of the Percus-Yevick approximation yield significant improvements for either type of particle. Making use of simple geometric considerations, our new method predicts a percolation threshold of $\rho_c l^2 \approx 5.83$ for segments of length $l$, which is close to the $\rho_c l^2 \approx 5.64$ found in Monte Carlo simulations. For disks of area $a$ we find $\rho_c a \approx 1.00$, close to the Monte Carlo result of $\rho_c a \approx 1.13$. We discuss the shortcomings of the conventional approaches and explain how usage of the nearest-neighbor distribution in our new method bypasses those complications.

We report the temporal and spectral analysis of three thermonuclear X-ray bursts from 4U 1608-52, observed by the Neutron Star Interior Composition Explorer (NICER) during and just after the outburst observed from the source in 2020. In two of the X-ray bursts, we detect secondary peaks, 30 and 18 seconds after the initial peaks. The secondary peaks show a fast rise exponential decay-like shape resembling a thermonuclear X-ray burst. Time-resolved X-ray spectral analysis reveals that the peak flux, blackbody temperature, and apparent emitting radius values of the initial peaks are in agreement with X-ray bursts previously observed from 4U 1608-52, while the same values for the secondary peaks tend toward the lower end of the distribution of bursts observed from this source. The third X-ray burst, which happened during much lower accretion rates did not show any evidence for a deviation from an exponential decay and was significantly brighter than the previous bursts. We present the properties of the secondary peaks and discuss the events within the framework of short recurrence time bursts or bursts with secondary peaks. We find that the current observations do not fit in standard scenarios and challenge our understanding of flame spreading., Comment: Accepted for publication in the Astrophysical Journal

We report the detection of 376.05 Hz (2.66 ms) coherent X-ray pulsations in NICER observations of a transient outburst of the low-mass X-ray binary IGR J17494-3030 in 2020 October/November. The system is an accreting millisecond X-ray pulsar in a 75 minute ultracompact binary. The mass donor is most likely a $\simeq 0.02 M_\odot$ finite-entropy white dwarf composed of He or C/O. The fractional rms pulsed amplitude is 7.4%, and the soft (1-3 keV) X-ray pulse profile contains a significant second harmonic. The pulsed amplitude and pulse phase lag (relative to our mean timing model) are energy-dependent, each having a local maximum at 4 keV and 1.5 keV, respectively. We also recovered the X-ray pulsations in archival 2012 XMM-Newton observations, allowing us to measure a long-term pulsar spin-down rate of $\dot\nu = -2.1(7)\times10^{-14}$ Hz/s and to infer a pulsar surface dipole magnetic field strength of $\simeq 10^9$ G. We show that the mass transfer in the binary is likely non-conservative, and we discuss various scenarios for mass loss from the system., Comment: 10 pages, 3 figures, and 1 table; accepted for publication in ApJL

In this work we report on observations with the Neutron Star Interior Composition Explorer of the known neutron star X-ray transient XTE J1739-285. We observed the source in 2020 February and March, finding it in a highly active bursting state. Across a 20-day period, we detected 32 thermonuclear X-ray bursts, with an average burst recurrence time of $2.0^{+0.4}_{-0.3}$ hr. A timing and spectral analysis of the ensemble of X-ray bursts reveals homogeneous burst properties, evidence for short-recurrence time bursts, and the detection of a 386.5 Hz burst oscillation candidate. The latter is especially notable, given that a previous study of this source claimed a 1122 Hz burst oscillation candidate. We did not find any evidence of variability near 1122 Hz, and instead find that the 386.5 Hz oscillation is the more prominent signal of the two burst oscillation candidates. Hence, we conclude it is unlikely that XTE J1739-285 has a sub-millisecond rotation period., Comment: 15 pages, 9 figures, 2 tables. Accepted for publication in ApJ

Nuclear pleomorphism, defined herein as the extent of abnormalities in the overall appearance of tumor nuclei, is one of the components of the three-tiered breast cancer grading. Given that nuclear pleomorphism reflects a continuous spectrum of variation, we trained a deep neural network on a large variety of tumor regions from the collective knowledge of several pathologists, without constraining the network to the traditional three-category classification. We also motivate an additional approach in which we discuss the additional benefit of normal epithelium as baseline, following the routine clinical practice where pathologists are trained to score nuclear pleomorphism in tumor, having the normal breast epithelium for comparison. In multiple experiments, our fully-automated approach could achieve top pathologist-level performance in select regions of interest as well as at whole slide images, compared to ten and four pathologists, respectively., Comment: 16 pages, 11 figures