Search

Your search keyword '"Bult A"' showing total 6,458 results
Start Over Author "Bult A"
6,458 results on '"Bult A"'

1. Supplementation With B. Infantis for Mitigation of Type 1 Diabetes Autoimmunity (SINT1A)

Author

Technical University of Munich, Kinderkrankenhaus auf der Bult, University Hospital Carl Gustav Carus, Skane University Hospital, Universitaire Ziekenhuizen KU Leuven, Medical University of Warsaw, Cambridge Biomedical Campus, Cambridge, UK, Royal Victoria Infirmary, Newcastle upon Tyne, UK, and Anette-Gabriele Ziegler, Director - Institute of Diabetes Research

Published
2024

7. Anti-viral Action Against Type 1 Diabetes Autoimmunity

Author

Helmholtz Zentrum München, University Hospital Carl Gustav Carus, Kinderkrankenhaus auf der Bult, Skane University Hospital, Universitaire Ziekenhuizen KU Leuven, Newcastle-upon-Tyne Hospitals NHS Trust, Cambridge University Hospitals NHS Foundation Trust, and Birmingham Women's and Children's NHS Foundation Trust

Published
2024

8. Bridging the gap: reflections on co-creation in knowledge translation

Author

Marjolijn Ketelaar, Maureen Bult, Marike Willems-op Het Veld, Karen van Meeteren, Marij Roebroeck, and Jeanine Voorman

Subjects
Knowledge translation, Co-creation, PPI, Experts by experience, Health care professionals, Cerebral palsy, Medicine, Medicine (General), R5-920
Abstract

Abstract Background To address the research-practice gap, knowledge translation is a crucial step in which co-creation, including patient and public involvement (PPI), is key. We performed a knowledge translation project in co-creation with all stakeholders as equal partners in the design and decision-making process. The project was based on scientific knowledge of a large research program on development of children and young adults with cerebral palsy (CP). It aimed to synthesize the knowledge on development of children and youth with CP, and to develop tools that are useful for health care professionals, persons with CP, and families. This paper describes the knowledge translation process applied in the project, specifically how the ‘key principles’ employed to ensure co-creation were operationalised, including reflections on the process and lessons learned. Main body Three key principles were defined to guarantee involvement of all stakeholders as equal partners in the design and decision-making process: a shared vision on collaboration and partnership, transparency: open and honest communication, and co-creation as a stepwise, iterative process. These key principles are based on literature and earlier experiences. They are described in more detail and are illustrated with examples from the knowledge translation project. The iterative co-creation process can be regarded as a cyclical process, including planning, conducting, reflection, evaluation, and refining the product and the process. This means that there was a continuous learning cycle in which we learned from the challenges and successes, now and then taking a step back. Based on our reflections the most important lessons learned are summarized. Conclusion The key principles were helpful in this knowledge translation process. Reflecting on these principles during the joint journey secured co-creation with all stakeholders as equal partners in the design and decision-making process. By sharing experiences, key principles, examples and lessons learned we intend to advance knowledge in PPI, and to inspire others.

Published
2024
Full Text
View/download PDF

9. X-ray and Radio Monitoring of the Neutron Star Low Mass X-ray Binary 1A 1744-361: Quasi Periodic Oscillations, Transient Ejections, and a Disk Atmosphere

Author

Ng, Mason, Hughes, Andrew K., Homan, Jeroen, Miller, Jon M., Pike, Sean N., Altamirano, Diego, Bult, Peter, Chakrabarty, Deepto, Buisson, D. J. K., Coughenour, Benjamin M., Fender, Rob, Guillot, Sebastien, Güver, Tolga, Jaisawal, Gaurava K., Jaodand, Amruta D., Malacaria, Christian, Miller-Jones, James C. A., Sanna, Andrea, Sivakoff, Gregory R., Strohmayer, Tod E., Tomsick, John A., and Eijnden, Jakob van den

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We report on X-ray (NICER/NuSTAR/MAXI/Swift) and radio (MeerKAT) timing and spectroscopic analysis from a three-month monitoring campaign in 2022 of a high-intensity outburst of the dipping neutron star low-mass X-ray binary 1A 1744-361. The 0.5-6.8 keV NICER X-ray hardness-intensity and color-color diagrams of the observations throughout the outburst suggests that 1A 1744-361 spent most of its outburst in an atoll-state, but we show that the source exhibited Z-state-like properties at the peak of the outburst, similar to a small sample of other atoll-state sources. A timing analysis with NICER data revealed several instances of an $\approx8$ Hz quasi-periodic oscillation (QPO; fractional rms amplitudes of ~5%) around the peak of the outburst, the first from this source, which we connect to the normal branch QPOs (NBOs) seen in the Z-state. Our observations of 1A 1744-361 are fully consistent with the idea of the mass accretion rate being the main distinguishing parameter between atoll- and Z-states. Radio monitoring data by MeerKAT suggests that the source was at its radio-brightest during the outburst peak, and that the source transitioned from the 'island' spectral state to the 'banana' state within ~3 days of the outburst onset, launching transient jet ejecta. The observations present the strongest evidence for radio flaring, including jet ejecta, during the island-to-banana spectral state transition at low accretion rates (atoll-state). The source also exhibited Fe XXV, Fe XXVI K$\alpha$, and K$\beta$ X-ray absorption lines, whose origins likely lie in an accretion disk atmosphere., Comment: 30 pages, 13 figures, and 8 tables. Accepted by ApJ (before proofs)

Published
2023

10. NICER observations of thermonuclear bursts from 4U 1728-34: Detection of oscillations prior to the onset of two bursts

Author

Bostanci, Funda, Boztepe, Tugba, Guver, Tolga, Strohmayer, Tod E., Cavecchi, Yuri, Gogus, Ersin, Altamirano, Diego, Bult, Peter, Chakrabarty, Deepto, Guillot, Sebastien, Jaisawal, Gaurava K., Malacaria, Christian, Mancuso, Giulio C., Sanna, Andrea, and Swank, Jean H.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We present temporal and time-resolved spectral analyses of all the thermonuclear X-ray bursts observed from the neutron star low-mass X-ray binary (LMXB) 4U 1728-34 with NICER from June 2017 to September 2019. In total, we detected 11 X-ray bursts from the source and performed time-resolved spectroscopy. Unlike some of the earlier results for other bursting sources from NICER, our spectral results indicate that the use of a scaling factor for the persistent emission is not statistically necessary. This is primarily a result of the strong interstellar absorption in the line of sight towards 4U 1728-34, which causes the count rates to be significantly lower at low energies. We also searched for burst oscillations and detected modulations in six different bursts at around the previously known burst oscillation frequency of 363 Hz. Finally, we report the detection of oscillations prior to two bursts at 356 and 359 Hz, respectively. This is the first time in the literature where burst oscillations are detected before the rapid rise in X-ray flux, from any known burster. These oscillations disappear as soon as the burst rise starts and occur at a somewhat lower frequency than the oscillations we detect during the bursts., Comment: Accepted for publication in the Astrophysical Journal

Published
2023

11. Preoperative breast MRI positively impacts surgical outcomes of needle biopsy–diagnosed pure DCIS: a patient-matched analysis from the MIPA study

Author

Cozzi, Andrea, Di Leo, Giovanni, Houssami, Nehmat, Gilbert, Fiona J., Helbich, Thomas H., Álvarez Benito, Marina, Balleyguier, Corinne, Bazzocchi, Massimo, Bult, Peter, Calabrese, Massimo, Camps Herrero, Julia, Cartia, Francesco, Cassano, Enrico, Clauser, Paola, de Lima Docema, Marcos F., Depretto, Catherine, Dominelli, Valeria, Forrai, Gábor, Girometti, Rossano, Harms, Steven E., Hilborne, Sarah, Ienzi, Raffaele, Lobbes, Marc B. I., Losio, Claudio, Mann, Ritse M., Montemezzi, Stefania, Obdeijn, Inge-Marie, Aksoy Ozcan, Umit, Pediconi, Federica, Pinker, Katja, Preibsch, Heike, Raya Povedano, José L., Rossi Saccarelli, Carolina, Sacchetto, Daniela, Scaperrotta, Gianfranco P., Schlooz, Margrethe, Szabó, Botond K., Taylor, Donna B., Ulus, Sila Ö., Van Goethem, Mireille, Veltman, Jeroen, Weigel, Stefanie, Wenkel, Evelyn, Zuiani, Chiara, and Sardanelli, Francesco

Published
2024
Full Text
View/download PDF

13. Minimum information and guidelines for reporting a Multiplexed Assay of Variant Effect

Author

Claussnitzer, Melina, Parikh, Victoria N., Wagner, Alex H., Arbesfeld, Jeremy A., Bult, Carol J., Firth, Helen V., Muffley, Lara A., Ba, Alex N. Nguyen, Riehle, Kevin, Roth, Frederick P., Tabet, Daniel, Bolognesi, Benedetta, Glazer, Andrew M., and Rubin, Alan F.

Subjects
Quantitative Biology - Other Quantitative Biology
Abstract

Multiplexed Assays of Variant Effect (MAVEs) have emerged as a powerful approach for interrogating thousands of genetic variants in a single experiment. The flexibility and widespread adoption of these techniques across diverse disciplines has led to a heterogeneous mix of data formats and descriptions, which complicates the downstream use of the resulting datasets. To address these issues and promote reproducibility and reuse of MAVE data, we define a set of minimum information standards for MAVE data and metadata and outline a controlled vocabulary aligned with established biomedical ontologies for describing these experimental designs.

Published
2023

14. Thermonuclear Type-I X-ray Bursts and Burst Oscillations from the Eclipsing AMXP Swift J1749.4-2807

Author

Albayati, A. C., Bult, P., Altamirano, D., Chenevez, J., Guillot, S., Güver, T., Jaisawal, G. K., Malacaria, C., Mancuso, G. C., Marino, A., Ng, M., Sanna, A., and Strohmayer, T. E.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Swift J1749.4-2807 is the only known eclipsing accreting millisecond X-ray pulsar. In this paper, we report on 7 thermonuclear (Type-I) X-ray bursts observed by NICER during its 2021 outburst. The first 6 bursts show slow rises and long decays, indicative of mixed H/He fuel, whereas the last burst shows fast rise and decay, suggesting He-rich fuel. Time-resolved spectroscopy of the bursts revealed typical phenomenology (i.e., an increase in black body temperature during the burst rise, and steady decrease in the decay), however they required a variable $N_\mathrm{H}$. We found that the values of $N_\mathrm{H}$ during the bursts were roughly double those found in the fits of the persistent emission prior to each burst. We interpret this change in absorption as evidence of burst-disc interaction, which we observe due to the high inclination of the system. We searched for burst oscillations during each burst and detected a signal in the first burst at the known spin frequency of the neutron star (517.92 Hz). This is the first time burst oscillations have been detected from Swift J1749.4-2807. We further find that each X-ray burst occurs on top of an elevated persistent count rate. We performed time-resolved spectroscopy on the combined data of the bursts with sufficient statistics (i.e., the clearest examples of this phenomenon) and found that the black body parameters evolve to hotter temperatures closer to the onset of the bursts. We interpret this as a consequence of an unusual marginally stable burning process similar to that seen through mHz QPOs., Comment: accepted for publication in MNRAS, 12 pages, 11 figures

Published
2023
Full Text
View/download PDF

15. The use of echocardiography compared to electrocardiogram when screening for left ventricular hypertrophy in hypertensive patients: A cross‐sectional study

Author

Marijn Marc Bult, Thomas Flint van deRee, Anna Maria Wind, Kai Morris Hurley, and Marcel Allard van deRee

Subjects
clinical management of high blood pressure (HBP), left ventricular hypertrophy (LVH) hypertension/arrhythmias, resistant hypertension, secondary high blood pressure (HBP), treatment and diagnosis/guidelines, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Left ventricular hypertrophy (LVH) is often used as an indicator to assess hypertension‐mediated organ damage (HMOD), alongside hypertensive retinopathy (HR) and nephropathy. Assessment of HMOD is crucial when making decisions about treatment optimization. Despite longstanding debate over its reliability to detect LVH, it is common practice to perform an electrocardiogram (ECG) instead of directly assessing left ventricular mass with echocardiography. In this study, the presence of LVH was evaluated using both ECG and echocardiography among consecutive patients suspected of therapy‐resistant hypertension or secondary hypertension in the outpatient clinic of the Department of Internal Medicine at the Diakonessen Hospital, Utrecht, the Netherlands, between July 15, 2017, and July 31, 2020. The primary endpoints were the specificity and sensitivity of ECG as a diagnostic tool for LVH, with echocardiography serving as the reference method. Among the 329 participants, we identified 70 individuals (21.3%) with true LVH based on echocardiography. The ECG displayed a sensitivity of 47.9% and a specificity of 75.3%. Moreover, the area under the receiver operating characteristics curve was 0.604. In conclusion, ECG demonstrates limited value in identifying LVH. Considering the importance of accurately assessing HMOD for treatment optimization of hypertension, the role of ECG as a diagnostic tool for LVH is, therefore, questionable. Instead, we recommend employing standard echocardiography as a more reliable diagnostic.

Published
2024
Full Text
View/download PDF

16. PLS3 missense variants affecting the actin-binding domains cause X-linked congenital diaphragmatic hernia and body-wall defects.

Author

Petit, Florence, Longoni, Mauro, Wells, Julie, Maser, Richard, Bogenschutz, Eric, Dysart, Matthew, Contreras, Hannah, Frénois, Frederic, Pober, Barbara, Clark, Robin, Giampietro, Philip, Ropers, Hilger, Hu, Hao, Loscertales, Maria, Wagner, Richard, Ai, Xingbin, Brand, Harrison, Jourdain, Anne-Sophie, Delrue, Marie-Ange, Gilbert-Dussardier, Brigitte, Devisme, Louise, Keren, Boris, McCulley, David, Qiao, Lu, Hernan, Rebecca, Wynn, Julia, Scott, Tiana, Calame, Daniel, Coban-Akdemir, Zeynep, Hernandez, Patricia, Hernandez-Garcia, Andres, Yonath, Hagith, Lupski, James, Shen, Yufeng, Chung, Wendy, Scott, Daryl, Bult, Carol, Donahoe, Patricia, and High, Frances

Subjects
PLS3, plastin, X-linked, abdominal hernia, actin-binding protein, congenital diaphragmatic hernia, fimbrin, omphalocele, umbilical hernia, Adult, Humans, Male, Animals, Mice, Hernias, Diaphragmatic, Congenital, Actins, Mutation, Missense, Osteoporosis
Abstract

Congenital diaphragmatic hernia (CDH) is a relatively common and genetically heterogeneous structural birth defect associated with high mortality and morbidity. We describe eight unrelated families with an X-linked condition characterized by diaphragm defects, variable anterior body-wall anomalies, and/or facial dysmorphism. Using linkage analysis and exome or genome sequencing, we found that missense variants in plastin 3 (PLS3), a gene encoding an actin bundling protein, co-segregate with disease in all families. Loss-of-function variants in PLS3 have been previously associated with X-linked osteoporosis (MIM: 300910), so we used in silico protein modeling and a mouse model to address these seemingly disparate clinical phenotypes. The missense variants in individuals with CDH are located within the actin-binding domains of the protein but are not predicted to affect protein structure, whereas the variants in individuals with osteoporosis are predicted to result in loss of function. A mouse knockin model of a variant identified in one of the CDH-affected families, c.1497G>C (p.Trp499Cys), shows partial perinatal lethality and recapitulates the key findings of the human phenotype, including diaphragm and abdominal-wall defects. Both the mouse model and one adult human male with a CDH-associated PLS3 variant were observed to have increased rather than decreased bone mineral density. Together, these clinical and functional data in humans and mice reveal that specific missense variants affecting the actin-binding domains of PLS3 might have a gain-of-function effect and cause a Mendelian congenital disorder.

Published
2023

17. Detection of millihertz quasi-periodic oscillations in the low-mass X-ray binary 4U 1730--22 with NICER

Author

Mancuso, G. C., Altamirano, D., Bult, P., Chenevez, J., Guillot, S., Guver, T., Jaisawal, G. K., Malacaria, C., Ng, M., Sanna, A., and Strohmayer, T. E.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We report the discovery of millihertz quasi-periodic oscillations (mHz QPOs) from the neutron star (NS) low-mass X-ray binary 4U 1730--22 using the Neutron Star Interior Composition Explorer (NICER). After being inactive for almost 50 years, 4U 1730--22 went into outburst twice between June and August 2021, and between February and July 2022. We analyse all the NICER observations of this source, and detect mHz QPOs with a significance > $4\sigma$ in 35 observations. The QPO frequency of the full data set ranged between ~4.5 and ~8.1 mHz with an average fractional rms amplitude of the order of ~2%. The X-ray colour analysis strongly suggests that 4U 1730--22 was in a soft spectral state during the QPO detections. Our findings are consistent with those reported for other sources where the mHz QPOs have been interpreted as the result of a special mode of He burning on the NS surface called marginally stable nuclear burning (MSNB). We conclude that the mHz QPOs reported in this work are also associated with the MSNB, making 4U 1730--22 the eighth source that shows this phenomenology. We discuss our findings in the context of the heat flux from the NS crust., Comment: 9 pages, 6 figures. Accepted for publication in MNRAS

Published
2023
Full Text
View/download PDF

18. Hydrogen-triggered X-ray Bursts from SAX J1808.4-3658? The Onset of Nuclear Burning

Author

Casten, Sierra, Strohmayer, Tod, and Bult, Peter

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We present a study of weak, thermonuclear X-ray bursts from the accreting millisecond X-ray pulsar SAX J1808.4-3658. We focus on a burst observed with the Neutron Star Interior Composition Explorer on 2019 August 9, and describe a similar burst observed with the Rossi X-ray Timing Explorer in 2005 June. These bursts occurred soon after outburst onset, $2.9$ and $1.1$ days, after the first indications of fresh accretion. We measure peak burst bolometric fluxes of $6.98 \pm 0.50 \times 10^{-9}$ and $1.54 \pm 0.10 \times 10^{-8}$ erg cm$^{-2}$ s$^{-1}$, respectively, which are factors of $\approx 30$ and $15$ less than the peak flux of the brightest, helium-powered bursts observed from this source. From spectral modeling we estimate accretion rates and accreted columns at the time of each burst. For the 2019 burst we estimate an accretion rate of $\dot M \approx 1.4-1.6 \times 10^{-10}$ $M_{\odot}$ yr$^{-1}$, and a column in the range $3.9-5.1 \times 10^7$ g cm$^{-2}$. For the 2005 event the accretion rate was similar, but the accreted column was half of that estimated for the 2019 burst. The low accretion rates, modest columns, and evidence for a cool neutron star in quiescence, suggest these bursts are triggered by thermally unstable CNO cycle hydrogen-burning. The post-burst flux level in the 2019 event appears offset from the pre-burst level by an amount consistent with quasi-stable hydrogen-burning due to the temperature-insensitive, hot-CNO cycle, further suggesting hydrogen-burning as the primary fuel source. This provides strong observational evidence for hydrogen-triggered bursts. We discuss our results in the context of previous theoretical modeling., Comment: 14 pages, 6 figures, 2 tables

Published
2023
Full Text
View/download PDF

21. Timing analysis of the 2022 outburst of the accreting millisecond X-ray pulsar SAX J1808.4$-$3658: hints of an orbital shrinking

Author

Illiano, Giulia, Papitto, Alessandro, Sanna, Andrea, Bult, Peter, Ambrosino, Filippo, Zanon, Arianna Miraval, Zelati, Francesco Coti, Stella, Luigi, Altamirano, Diego, Baglio, Maria Cristina, Bozzo, Enrico, Burderi, Luciano, de Martino, Domitilla, Di Marco, Alessandro, di Salvo, Tiziana, Ferrigno, Carlo, Loktev, Vladislav, Marino, Alessio, Ng, Mason, Pilia, Maura, Poutanen, Juri, and Salmi, Tuomo

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We present a pulse timing analysis of NICER observations of the accreting millisecond X-ray pulsar SAX J1808.4$-$3658 during the outburst that started on 2022 August 19. Similar to previous outbursts, after decaying from a peak luminosity of $\simeq 1\times10^{36} \, \mathrm{erg \, s^{-1}}$ in about a week, the pulsar entered in a $\sim 1$ month-long reflaring stage. Comparison of the average pulsar spin frequency during the outburst with those previously measured confirmed the long-term spin derivative of $\dot{\nu}_{\textrm{SD}}=-(1.15\pm0.06)\times 10^{-15} \, \mathrm{Hz\,s^{-1}}$, compatible with the spin-down torque of a $\approx 10^{26} \, \mathrm{G \, cm^3}$ rotating magnetic dipole. For the first time in the last twenty years, the orbital phase evolution shows evidence for a decrease of the orbital period. The long-term behaviour of the orbit is dominated by a $\sim 11 \, \mathrm{s}$ modulation of the orbital phase epoch consistent with a $\sim 21 \, \mathrm{yr}$ period. We discuss the observed evolution in terms of a coupling between the orbit and variations in the mass quadrupole of the companion star., Comment: 11 pages, 3 figures, 1 table. Accepted for publication in ApJ Letters

Published
2022
Full Text
View/download PDF

23. The thermonuclear X-ray bursts of 4U 1730-22

Author

Bult, Peter, Mancuso, Giulio C., Strohmayer, Tod E., Albayati, Arianna C., Altamirano, Diego, Buisson, Douglas J. K., Chenevez, Jérôme, Guillot, Sebastien, Güver, Tolga, Iwakiri, Wataru, Jaisawal, Gaurava K., Ng, Mason, Sanna, Andrea, and Swank, Jean H.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We present observations of the historic transient 4U 1730-22 as observed with the Neutron Star Interior Composition Explorer (NICER). After remaining in quiescence since its 1972 discovery, this X-ray binary showed renewed outburst activity in 2021 and 2022. We observed 4U 1730-22 extensively with NICER, detecting a total of 17 thermonuclear X-ray bursts. From a spectroscopic analysis, we find that these X-ray bursts can be divided into a group of bright and weak bursts. All bright bursts showed $1\sim2$ second rise times and a photospheric radius expansion phase, while the weak bursts showed a slower $\sim5$ second rise with a tendency for concave shapes. From the photospheric radius expansion flux, we estimate the source distance at $6.9\pm0.2$ kpc. We consider various interpretations for our observations and suggest that they may be explained if accreted material is burning stably at the stellar equator, and unstable ignition occurs at a range of higher latitudes., Comment: 13 pages, 6 figures, 2 tables. Accepted for publication in ApJ

Published
2022
Full Text
View/download PDF

24. MAXI J1957+032: a new accreting millisecond X-ray pulsar in an ultra-compact binary

Author

Sanna, A., Bult, P., NG, M., Ray, P. S., Jaisawal, G. K., Burderi, L., Di Salvo, T., Riggio, A., Altamirano, D., Strohmayer, T. E., Manca, A., Gendreau, K. C., Chakrabarty, D., Iwakiri, W., and Iaria, R.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The detection of coherent X-ray pulsations at ~314 Hz (3.2 ms) classifies MAXI J1957+032 as a fast-rotating, accreting neutron star. We present the temporal and spectral analysis performed using NICER observations collected during the latest outburst of the source. Doppler modulation of the X-ray pulsation revealed the ultra-compact nature of the binary system characterised by an orbital period of ~1 hour and a projected semi-major axis of 14 lt-ms. The neutron star binary mass function suggests a minimum donor mass of 1.7e-2 Msun, assuming a neutron star mass of 1.4 Msun and a binary inclination angle lower than 60 degrees. This assumption is supported by the lack of eclipses or dips in the X-ray light curve of the source. We characterised the 0.5-10 keV energy spectrum of the source in outburst as the superposition of a relatively cold black-body-like thermal emission compatible with the emission from the neutron star surface and a Comptonisation component with photon index consistent with a typical hard state. We did not find evidence for iron K-alpha lines or reflection components., Comment: 5 pages, 4 figures. Accepted for publication in MNRAS

Published
2022
Full Text
View/download PDF

25. The discovery of the 528.6 Hz accreting millisecond X-ray pulsar MAXI J1816-195

Author

Bult, Peter, Altamirano, Diego, Arzoumanian, Zaven, Chakrabarty, Deepto, Chenevez, Jérôme, Ferrara, Elizabeth C., Gendreau, Keith C., Guillot, Sebastien, Güver, Tolga, Iwakiri, Wataru, Jaisawal, Gaurava K., Mancuso, Giulio C., Malacaria, Christian, Ng, Mason, Sanna, Andrea, Strohmayer, Tod E., Wadiasingh, Zorawar, and Wolff, Michael T.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We present the discovery of 528.6 Hz pulsations in the new X-ray transient MAXI J1816-195. Using NICER, we observed the first recorded transient outburst from the neutron star low-mass X-ray binary MAXI J1816-195 over a period of 28 days. From a timing analysis of the 528.6 Hz pulsations, we find that the binary system is well described as a circular orbit with an orbital period of 4.8 hours and a projected semi-major axis of 0.26 light-seconds for the pulsar, which constrains the mass of the donor star to $0.10-0.55 M_\odot$. Additionally, we observed 15 thermonuclear X-ray bursts showing a gradual evolution in morphology over time, and a recurrence time as short as 1.4 hours. We did not detect evidence for photospheric radius expansion, placing an upper limit on the source distance of 8.6 kpc., Comment: 8 pages, 3 figures, 2 tables. Accepted for publication in ApJ Letters

Published
2022
Full Text
View/download PDF

26. Higher prevalence of dupilumab‐induced ocular adverse events in atopic dermatitis compared to asthma: A daily practice analysis

Author

Anne R. Schlösser, Lotte Bult, John C. Thelen, Alberta A. H. J. Thiadens, Renske Schappin, Tamar E. C. Nijsten, Johannes C. C. M. in 't Veen, Gerrit J. Braunstahl, and DirkJan Hijnen

Subjects
atopic dermatitis, dupilumab, dupilumab ocular surface disease, severe asthma, T2‐inflammation, Immunologic diseases. Allergy, RC581-607
Abstract

Abstract Background Dupilumab has been shown to be an effective treatment in moderate‐to‐severe atopic dermatitis (AD) and severe asthma (SA). However, comparative real‐world analyses of adverse events (AE), particularly dupilumab‐associated ocular surface disease (DAOSD), are lacking. Objective This is the first real‐world study to provide insight into the prevalence of AEs associated with dupilumab in AD compared with SA. Secondary objectives were to assess the prevalence, onset and therapeutic strategies of DAOSD and evaluate dupilumab discontinuation rates. Methods Data from two daily practice registries including AD and SA patients receiving dupilumab treatment were analyzed. Adverse events, including DAOSD, were evaluated. Results In total, 322 AD and 148 SA patients were included. Headaches (23.6%), injection site reactions (10.1%), and influenza‐like symptoms (13.5%) were more prevalent in SA patients. Interestingly, ocular AEs were significantly more prevalent in AD patients (62.1%, p

Published
2024
Full Text
View/download PDF

27. Outflows and spectral evolution in the eclipsing AMXP SWIFT J1749.4-2807 with NICER, XMM-Newton and NuSTAR

Author

Marino, A., Anitra, A., Mazzola, S. M., Di Salvo, T., Sanna, A., Bult, P., Guillot, S., Mancuso, G., Ng, M., Riggio, A., Albayati, A. C., Altamirano, D., Arzoumanian, Z., Burderi, L., Cabras, C., Chakrabarty, D., Deiosso, N., Gendreau, K. C., Iaria, R., Manca, A., and Strohmayer, T. E.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The neutron star low-mass X-ray binary SWIFT J1749.4-2807 is the only known eclipsing accreting millisecond X-ray pulsar. In this manuscript we perform a spectral characterization of the system throughout its 2021, two-week-long outburst, analyzing 11 NICER observations and quasi-simultaneous XMM-Newton and NuSTAR single observations at the outburst peak. The broadband spectrum is well-modeled with a black body component with a temperature of $\sim$0.6 keV, most likely consistent with a hot spot on the neutron star surface, and a Comptonisation spectrum with power-law index $\Gamma \sim 1.9$, arising from a hot corona at $\sim$12 keV. No direct emission from the disc was found, possibly due to it being too cool. A high truncation radius for the disc, i.e., at $\sim$20--30 R$_{G}$ , was obtained from the analysis of the broadened profile of the Fe line in the reflection component. The significant detection of a blue-shifted Fe XXVI absorption line at $\sim$7 keV indicates weakly relativistic X-ray disc winds, which are typically absent in the hard state of X-ray binaries. By comparing the low flux observed during the outburst and the one expected in a conservative mass-transfer, we conclude that mass-transfer in the system is highly non-conservative, as also suggested by the wind detection. Finally, using the Nicer spectra alone, we followed the system while it was fading to quiescence. During the outburst decay, as the spectral shape hardened, the hot spot on the neutron star surface cooled down and shrank, a trend which could be consistent with the pure power-law spectrum observed during quiescence., Comment: 15 pages, 9 figure; accepted for publication on MNRAS

Published
2022
Full Text
View/download PDF

28. Burst-Disk Interaction in 4U 1636-536 as observed by NICER

Author

Guver, Tolga, Bostanci, Funda, Boztepe, Tugba, Gogus, Ersin, Bult, Peter, Kashyap, Unnati, Chakraborty, Manoneeta, Ballantyne, David R., Ludlam, Renee, Malacaria, Christian, Jaisawal, Gaurava K., Strohmayer, Tod E., and Guillot, Sebastien

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Solar and Stellar Astrophysics
Abstract

We present the detection of 51 thermonuclear X-ray bursts observed from 4U 1636-536 by the Neutron Star Interior Composition Explorer (NICER) over the course of a three year monitoring campaign. We performed time resolved spectroscopy for 40 of these bursts and showed the existence of a strong soft excess in all the burst spectra. The excess emission can be characterized by the use of a scaling factor (f_a method) to the persistent emission of the source, which is attributed to the increased mass accretion rate on to the neutron star due to Poynting-Robertson drag. The soft excess emission can also be characterized by the use of a model taking into account the reflection of the burst emission off of the accretion disk. We also present time resolved spectral analysis of 5 X-ray bursts simultaneously observed by NICER and AstroSat, which confirm the main results with even greater precision. Finally, we present evidence for Compton cooling using 7 X-ray bursts observed contemporaneously with \nustar, by means of a correlated decrease in the hard X-ray lightcurve of 4U 1636-536 as the bursts start., Comment: Accepted for publication in the Astrophysical Journal

Published
2022
Full Text
View/download PDF

29. On the peculiar long-term orbital evolution of the eclipsing accreting millisecond X-ray pulsar SWIFT J1749.4-2807

Author

Sanna, A., Burderi, L., Di Salvo, T., Riggio, A., Altamirano, D., Marino, A., Bult, P., Strohmayer, T. E., Guillot, S., Malacaria, C., Ng, M., Mancuso, G., Mazzola, S. M., Albayati, A. C., Iaria, R., Manca, A., Cabras, C., and Anitra, A.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

We present the pulsar timing analysis of the accreting millisecond X-ray pulsar SWIFT J1749.4-2807 monitored by NICER and XMM-Newton during its latest outburst after almost eleven years of quiescence. From the coherent timing analysis of the pulse profiles, we updated the orbital ephemerides of the system. Large phase jumps of the fundamental frequency phase of the signal are visible during the outburst, consistent with what was observed during the previous outburst. Moreover, we report on the marginally significant evidence for non-zero eccentricity ($e\simeq 4\times 10^{-5}$) obtained independently from the analysis of both the 2021 and 2010 outbursts and we discuss possible compatible scenarios. Long-term orbital evolution of SWIFT J1749.4-2807 suggests a fast expansion of both the NS projected semi-major axis $(x)$, and the orbital period $(P_{\rm orb})$, at a rate of $\dot{x}\simeq 2.6\times 10^{-13}\,\text{lt-s}\,\text{s}^{-1}$ and $\dot{P}_{\rm orb}\simeq 4 \times 10^{-10}\,\text{s}\,\text{s}^{-1}$, respectively. SWIFT J1749.4-2807 is the only accreting millisecond X-ray pulsar, so far, from which the orbital period derivative has been directly measured from appreciable changes on the observed orbital period. Finally, no significant secular deceleration of the spin frequency of the compact object is detected, which allowed us to set a constraint on the magnetic field strength at the polar caps of $B_{PC}<1.3\times 10^{8}~\text{G}$, in line with typical values reported for AMXPs., Comment: 13 pages, 3 figures, 1 table. Accepted for publication in MNRAS

Published
2022
Full Text
View/download PDF

31. The Effect of Frequent Continuous Glucose Monitoring Use on Glucose Variability in Preschoolers With Type 1 Diabetes

Author

International Society for Pediatric and Adolescent Diabetes, Kinderkrankenhaus auf der Bult, Hannover, Germany, Department of Pediatrcs, Endocrinology and Diabetes Medical University of Silesia in Katowice, Poland, Pediatric Diabetes and Metabolic Disorders Unit, Regional Center for Pediatric Diabetes, University City Hospital of Verona, Verona, Italy, Yale University School of Medicine, Department of Pediatrics, New Haven, Connecticut, United States, Pediatric Endocrinology Unit, Paediatrics Department, Maternal and Paediatrics Centre, São João University and Hospital Centre, Porto, Porto, Portugal, Department of Pediatrics, Section on Diabetes and Metabolism, V. Buzzi Children's Hospital, University of Milan, Milan, Italy, Pediatric Endocrinology Unit. Hospital Pediátrico. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal, Diaboss, Amsterdam, Netherlands, Medical School, University of Valparaiso, San Felipe, Chile., Department of Pediatric Endocrinology and Diabetes, Koç University Hospital, İstanbul, Turkey., University of Roma La Sapienza, and Department of Pediatrics, San Raffaele Scientific Institute , Milan, Italy

Published
2023

32. Lessons learned from 20 years of preclinical testing in pediatric cancers

Author

Smith, Malcolm A., Houghton, Peter J., Lock, Richard B., Maris, John M., Gorlick, Richard, Kurmasheva, Raushan T., Li, Xiao-Nan, Teicher, Beverly A., Chuang, Jeffrey H., Dela Cruz, Filemon S., Dyer, Michael A., Kung, Andrew L., Lloyd, Michael W., Mossé, Yael P., Stearns, Timothy M., Stewart, Elizabeth A., Bult, Carol J., and Erickson, Stephen W.

Published
2024
Full Text
View/download PDF

33. Mouse models of NADK2 deficiency analyzed for metabolic and gene expression changes to elucidate pathophysiology

Author

Murray, GC, Bais, P, Hatton, CL, Tadenev, ALD, Hoffmann, BR, Stodola, TJ, Morelli, KH, Pratt, SL, Schroeder, D, Doty, R, Fiehn, O, John, SWM, Bult, CJ, Cox, GA, and Burgess, RW

Subjects
Biological Sciences, Bioinformatics and Computational Biology, Neurosciences, Human Genome, Rare Diseases, Pediatric, Neurodegenerative, Genetics, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Musculoskeletal, Neurological, Animals, Mice, Humans, Hyperlysinemias, NAD, Neuroaxonal Dystrophies, Disease Models, Animal, Gene Expression, Phosphotransferases (Alcohol Group Acceptor), Mitochondrial Proteins, Group VI Phospholipases A2, Medical and Health Sciences, Genetics & Heredity
Abstract

NADK2 encodes the mitochondrial form of nicotinamide adenine dinucleotide (NAD) kinase, which phosphorylates NAD. Rare recessive mutations in human NADK2 are associated with a syndromic neurological mitochondrial disease that includes metabolic changes, such as hyperlysinemia and 2,4 dienoyl CoA reductase (DECR) deficiency. However, the full pathophysiology resulting from NADK2 deficiency is not known. Here, we describe two chemically induced mouse mutations in Nadk2-S326L and S330P-which cause severe neuromuscular disease and shorten lifespan. The S330P allele was characterized in detail and shown to have marked denervation of neuromuscular junctions by 5 weeks of age and muscle atrophy by 11 weeks of age. Cerebellar Purkinje cells also showed progressive degeneration in this model. Transcriptome profiling on brain and muscle was performed at early and late disease stages. In addition, metabolomic profiling was performed on the brain, muscle, liver and spinal cord at the same ages and on plasma at 5 weeks. Combined transcriptomic and metabolomic analyses identified hyperlysinemia, DECR deficiency and generalized metabolic dysfunction in Nadk2 mutant mice, indicating relevance to the human disease. We compared findings from the Nadk model to equivalent RNA sequencing and metabolomic datasets from a mouse model of infantile neuroaxonal dystrophy, caused by recessive mutations in Pla2g6. This enabled us to identify disrupted biological processes that are common between these mouse models of neurological disease, as well as those processes that are gene-specific. These findings improve our understanding of the pathophysiology of neuromuscular diseases and describe mouse models that will be useful for future preclinical studies.

Published
2022

34. A Genomically and Clinically Annotated Patient-Derived Xenograft (PDX) Resource for Preclinical Research in Non-Small Cell Lung Cancer

Author

Woo, Xing Yi, Srivastava, Anuj, Mack, Philip C, Graber, Joel H, Sanderson, Brian J, Lloyd, Michael W, Chen, Mandy, Domanskyi, Sergii, Gandour-Edwards, Regina, Tsai, Rebekah A, Keck, James, Cheng, Mingshan, Bundy, Margaret, Jocoy, Emily L, Riess, Jonathan W, Holland, William, Grubb, Stephen C, Peterson, James G, Stafford, Grace A, Paisie, Carolyn, Neuhauser, Steven B, Karuturi, R Krishna Murthy, George, Joshy, Simons, Allen K, Chavaree, Margaret, Tepper, Clifford G, Goodwin, Neal, Airhart, Susan D, Lara, Primo N, Openshaw, Thomas H, Liu, Edison T, Gandara, David R, and Bult, Carol J

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Genetics, Lung, Orphan Drug, Precision Medicine, Human Genome, Cancer Genomics, Women's Health, Rare Diseases, Lung Cancer, Cancer, Biotechnology, 5.1 Pharmaceuticals, 5.9 Resources and infrastructure (treatment development), Good Health and Well Being, Humans, Animals, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Heterografts, Xenograft Model Antitumor Assays, Adenocarcinoma of Lung, Disease Models, Animal, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

Patient-derived xenograft (PDX) models are an effective preclinical in vivo platform for testing the efficacy of novel drugs and drug combinations for cancer therapeutics. Here we describe a repository of 79 genomically and clinically annotated lung cancer PDXs available from The Jackson Laboratory that have been extensively characterized for histopathologic features, mutational profiles, gene expression, and copy-number aberrations. Most of the PDXs are models of non-small cell lung cancer (NSCLC), including 37 lung adenocarcinoma (LUAD) and 33 lung squamous cell carcinoma (LUSC) models. Other lung cancer models in the repository include four small cell carcinomas, two large cell neuroendocrine carcinomas, two adenosquamous carcinomas, and one pleomorphic carcinoma. Models with both de novo and acquired resistance to targeted therapies with tyrosine kinase inhibitors are available in the collection. The genomic profiles of the LUAD and LUSC PDX models are consistent with those observed in patient tumors from The Cancer Genome Atlas and previously characterized gene expression-based molecular subtypes. Clinically relevant mutations identified in the original patient tumors were confirmed in engrafted PDX tumors. Treatment studies performed in a subset of the models recapitulated the responses expected on the basis of the observed genomic profiles. These models therefore serve as a valuable preclinical platform for translational cancer research.SignificancePatient-derived xenografts of lung cancer retain key features observed in the originating patient tumors and show expected responses to treatment with standard-of-care agents, providing experimentally tractable and reproducible models for preclinical investigations.

Published
2022

35. Detection of circulating tumor DNA in plasma of patients with primary CNS lymphoma by digital droplet PCR

Author

Yujie Zhong, Geok Wee Tan, Johanna Bult, Nick Veltmaat, Wouter Plattel, Joost Kluiver, Roelien Enting, Arjan Diepstra, Anke van den Berg, and Marcel Nijland

Subjects
Circulating tumor DNA, Primary central nervous system lymphoma, MYD88, CD79B, Liquid biopsy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Primary central nervous system lymphoma (PCNSL) are rare mature B-cell lymphoproliferative diseases characterized by a high incidence of MYD88 L265P and CD79B Y196 hotspot mutations. Diagnosis of PCNSL can be challenging. The aim of the study was to analyze the detection rate of the MYD88 L265P and CD79B Y196 mutation in cell free DNA (cfDNA) in plasma of patients with PCNSL. Methods We analyzed by digital droplet PCR (ddPCR) to determine presence of the MYD88 L265P and CD79B Y196 hotspot mutations in cfDNA isolated from plasma of 24 PCNSL patients with active disease. Corresponding tumor samples were available for 14 cases. Based on the false positive rate observed in 8 healthy control samples, a stringent cut-off for the MYD88 L265P and CD79B Y196 mutation were set at 0.3% and 0.5%, respectively. Results MYD88 L265P and CD79B Y196 mutations were detected in 9/14 (64%) and 2/13 (15%) tumor biopsies, respectively. In cfDNA samples, the MYD88 L265P mutation was detected in 3/24 (12.5%), while the CD79B Y196 mutation was not detected in any of the 23 tested cfDNA samples. Overall, MYD88 L265P and/or CD79B Y196 were detected in cfDNA in 3/24 cases (12.5%). The detection rate of the combined analysis did not improve the single detection rate for either MYD88 L265P or CD79B Y196. Conclusion The low detection rate of MYD88 L265P and CD79B Y196 mutations in cfDNA in the plasma of PCNSL patients argues against its use in routine diagnostics. However, detection of MYD88 L265P by ddPCR in cfDNA in the plasma could be considered in challenging cases.

Published
2024
Full Text
View/download PDF

36. Minimum information and guidelines for reporting a multiplexed assay of variant effect

Author

Melina Claussnitzer, Victoria N. Parikh, Alex H. Wagner, Jeremy A. Arbesfeld, Carol J. Bult, Helen V. Firth, Lara A. Muffley, Alex N. Nguyen Ba, Kevin Riehle, Frederick P. Roth, Daniel Tabet, Benedetta Bolognesi, Andrew M. Glazer, and Alan F. Rubin

Subjects
Genomics, Standards, Genetic variants, Multiplexed assays of variant effect, MAVE, Deep mutational scanning, Biology (General), QH301-705.5, Genetics, QH426-470
Abstract

Abstract Multiplexed assays of variant effect (MAVEs) have emerged as a powerful approach for interrogating thousands of genetic variants in a single experiment. The flexibility and widespread adoption of these techniques across diverse disciplines have led to a heterogeneous mix of data formats and descriptions, which complicates the downstream use of the resulting datasets. To address these issues and promote reproducibility and reuse of MAVE data, we define a set of minimum information standards for MAVE data and metadata and outline a controlled vocabulary aligned with established biomedical ontologies for describing these experimental designs.

Published
2024
Full Text
View/download PDF

37. Consistent patterns of common species across tropical tree communities

Author

Cooper, Declan L. M., Lewis, Simon L., Sullivan, Martin J. P., Prado, Paulo I., ter Steege, Hans, Barbier, Nicolas, Slik, Ferry, Sonké, Bonaventure, Ewango, Corneille E. N., Adu-Bredu, Stephen, Affum-Baffoe, Kofi, de Aguiar, Daniel P. P., Ahuite Reategui, Manuel Augusto, Aiba, Shin-Ichiro, Albuquerque, Bianca Weiss, de Almeida Matos, Francisca Dionízia, Alonso, Alfonso, Amani, Christian A., do Amaral, Dário Dantas, do Amaral, Iêda Leão, Andrade, Ana, de Andrade Miranda, Ires Paula, Angoboy, Ilondea B., Araujo-Murakami, Alejandro, Arboleda, Nicolás Castaño, Arroyo, Luzmila, Ashton, Peter, Aymard C, Gerardo A., Baider, Cláudia, Baker, Timothy R., Balinga, Michael Philippe Bessike, Balslev, Henrik, Banin, Lindsay F., Bánki, Olaf S., Baraloto, Chris, Barbosa, Edelcilio Marques, Barbosa, Flávia Rodrigues, Barlow, Jos, Bastin, Jean-Francois, Beeckman, Hans, Begne, Serge, Bengone, Natacha Nssi, Berenguer, Erika, Berry, Nicholas, Bitariho, Robert, Boeckx, Pascal, Bogaert, Jan, Bonyoma, Bernard, Boundja, Patrick, Bourland, Nils, Boyemba Bosela, Faustin, Brambach, Fabian, Brienen, Roel, Burslem, David F. R. P., Camargo, José Luís, Campelo, Wegliane, Cano, Angela, Cárdenas, Sasha, Cárdenas López, Dairon, de Sá Carpanedo, Rainiellen, Carrero Márquez, Yrma Andreina, Carvalho, Fernanda Antunes, Casas, Luisa Fernanda, Castellanos, Hernán, Castilho, Carolina V., Cerón, Carlos, Chapman, Colin A., Chave, Jerome, Chhang, Phourin, Chutipong, Wanlop, Chuyong, George B., Cintra, Bruno Barçante Ladvocat, Clark, Connie J., Coelho de Souza, Fernanda, Comiskey, James A., Coomes, David A., Cornejo Valverde, Fernando, Correa, Diego F., Costa, Flávia R. C., Costa, Janaina Barbosa Pedrosa, Couteron, Pierre, Culmsee, Heike, Cuni-Sanchez, Aida, Dallmeier, Francisco, Damasco, Gabriel, Dauby, Gilles, Dávila, Nállarett, Dávila Doza, Hilda Paulette, De Alban, Jose Don T., de Assis, Rafael L., De Canniere, Charles, De Haulleville, Thales, de Jesus Veiga Carim, Marcelo, Demarchi, Layon O., Dexter, Kyle G., Di Fiore, Anthony, Din, Hazimah Haji Mohammad, Disney, Mathias I., Djiofack, Brice Yannick, Djuikouo, Marie-Noël K., Do, Tran Van, Doucet, Jean-Louis, Draper, Freddie C., Droissart, Vincent, Duivenvoorden, Joost F., Engel, Julien, Estienne, Vittoria, Farfan-Rios, William, Fauset, Sophie, Feeley, Kenneth J., Feitosa, Yuri Oliveira, Feldpausch, Ted R., Ferreira, Cid, Ferreira, Joice, Ferreira, Leandro Valle, Fletcher, Christine D., Flores, Bernardo Monteiro, Fofanah, Alusine, Foli, Ernest G., Fonty, Émile, Fredriksson, Gabriella M., Fuentes, Alfredo, Galbraith, David, Gallardo Gonzales, George Pepe, Garcia-Cabrera, Karina, García-Villacorta, Roosevelt, Gomes, Vitor H. F., Gómez, Ricardo Zárate, Gonzales, Therany, Gribel, Rogerio, Guedes, Marcelino Carneiro, Guevara, Juan Ernesto, Hakeem, Khalid Rehman, Hall, Jefferson S., Hamer, Keith C., Hamilton, Alan C., Harris, David J., Harrison, Rhett D., Hart, Terese B., Hector, Andy, Henkel, Terry W., Herbohn, John, Hockemba, Mireille B. N., Hoffman, Bruce, Holmgren, Milena, Honorio Coronado, Euridice N., Huamantupa-Chuquimaco, Isau, Hubau, Wannes, Imai, Nobuo, Irume, Mariana Victória, Jansen, Patrick A., Jeffery, Kathryn J., Jimenez, Eliana M., Jucker, Tommaso, Junqueira, André Braga, Kalamandeen, Michelle, Kamdem, Narcisse G., Kartawinata, Kuswata, Kasongo Yakusu, Emmanuel, Katembo, John M., Kearsley, Elizabeth, Kenfack, David, Kessler, Michael, Khaing, Thiri Toe, Killeen, Timothy J., Kitayama, Kanehiro, Klitgaard, Bente, Labrière, Nicolas, Laumonier, Yves, Laurance, Susan G. W., Laurance, William F., Laurent, Félix, Le, Tinh Cong, Le, Trai Trong, Leal, Miguel E., Leão de Moraes Novo, Evlyn Márcia, Levesley, Aurora, Libalah, Moses B., Licona, Juan Carlos, Lima Filho, Diógenes de Andrade, Lindsell, Jeremy A., Lopes, Aline, Lopes, Maria Aparecida, Lovett, Jon C., Lowe, Richard, Lozada, José Rafael, Lu, Xinghui, Luambua, Nestor K., Luize, Bruno Garcia, Maas, Paul, Magalhães, José Leonardo Lima, Magnusson, William E., Mahayani, Ni Putu Diana, Makana, Jean-Remy, Malhi, Yadvinder, Maniguaje Rincón, Lorena, Mansor, Asyraf, Manzatto, Angelo Gilberto, Marimon, Beatriz S., Marimon-Junior, Ben Hur, Marshall, Andrew R, Martins, Maria Pires, Mbayu, Faustin M., de Medeiros, Marcelo Brilhante, Mesones, Italo, Metali, Faizah, Mihindou, Vianet, Millet, Jerome, Milliken, William, Mogollón, Hugo F., Molino, Jean-François, Mohd. Said, Mohd. Nizam, Monteagudo Mendoza, Abel, Montero, Juan Carlos, Moore, Sam, Mostacedo, Bonifacio, Mozombite Pinto, Linder Felipe, Mukul, Sharif Ahmed, Munishi, Pantaleo K. T., Nagamasu, Hidetoshi, Nascimento, Henrique Eduardo Mendonça, Nascimento, Marcelo Trindade, Neill, David, Nilus, Reuben, Noronha, Janaína Costa, Nsenga, Laurent, Núñez Vargas, Percy, Ojo, Lucas, Oliveira, Alexandre A., de Oliveira, Edmar Almeida, Ondo, Fidèle Evouna, Palacios Cuenca, Walter, Pansini, Susamar, Pansonato, Marcelo Petratti, Paredes, Marcos Ríos, Paudel, Ekananda, Pauletto, Daniela, Pearson, Richard G., Pena, José Luis Marcelo, Pennington, R. Toby, Peres, Carlos A., Permana, Andrea, Petronelli, Pascal, Peñuela Mora, Maria Cristina, Phillips, Juan Fernando, Phillips, Oliver L., Pickavance, Georgia, Piedade, Maria Teresa Fernandez, Pitman, Nigel C. A., Ploton, Pierre, Popelier, Andreas, Poulsen, John R., Prieto, Adriana, Primack, Richard B., Priyadi, Hari, Qie, Lan, Quaresma, Adriano Costa, de Queiroz, Helder Lima, Ramirez-Angulo, Hirma, Ramos, José Ferreira, Reis, Neidiane Farias Costa, Reitsma, Jan, Revilla, Juan David Cardenas, Riutta, Terhi, Rivas-Torres, Gonzalo, Robiansyah, Iyan, Rocha, Maira, Rodrigues, Domingos de Jesus, Rodriguez-Ronderos, M. Elizabeth, Rovero, Francesco, Rozak, Andes H., Rudas, Agustín, Rutishauser, Ervan, Sabatier, Daniel, Sagang, Le Bienfaiteur, Sampaio, Adeilza Felipe, Samsoedin, Ismayadi, Satdichanh, Manichanh, Schietti, Juliana, Schöngart, Jochen, Scudeller, Veridiana Vizoni, Seuaturien, Naret, Sheil, Douglas, Sierra, Rodrigo, Silman, Miles R., Silva, Thiago Sanna Freire, da Silva Guimarães, José Renan, Simo-Droissart, Murielle, Simon, Marcelo Fragomeni, Sist, Plinio, Sousa, Thaiane R., de Sousa Farias, Emanuelle, de Souza Coelho, Luiz, Spracklen, Dominick V., Stas, Suzanne M., Steinmetz, Robert, Stevenson, Pablo R., Stropp, Juliana, Sukri, Rahayu S., Sunderland, Terry C. H., Suzuki, Eizi, Swaine, Michael D., Tang, Jianwei, Taplin, James, Taylor, David M., Tello, J. Sebastián, Terborgh, John, Texier, Nicolas, Theilade, Ida, Thomas, Duncan W., Thomas, Raquel, Thomas, Sean C., Tirado, Milton, Toirambe, Benjamin, de Toledo, José Julio, Tomlinson, Kyle W., Torres-Lezama, Armando, Tran, Hieu Dang, Tshibamba Mukendi, John, Tumaneng, Roven D., Umaña, Maria Natalia, Umunay, Peter M., Urrego Giraldo, Ligia Estela, Valderrama Sandoval, Elvis H., Valenzuela Gamarra, Luis, Van Andel, Tinde R., van de Bult, Martin, van de Pol, Jaqueline, van der Heijden, Geertje, Vasquez, Rodolfo, Vela, César I. A., Venticinque, Eduardo Martins, Verbeeck, Hans, Veridiano, Rizza Karen A., Vicentini, Alberto, Vieira, Ima Célia Guimarães, Vilanova Torre, Emilio, Villarroel, Daniel, Villa Zegarra, Boris Eduardo, Vleminckx, Jason, von Hildebrand, Patricio, Vos, Vincent Antoine, Vriesendorp, Corine, Webb, Edward L., White, Lee J. T., Wich, Serge, Wittmann, Florian, Zagt, Roderick, Zang, Runguo, Zartman, Charles Eugene, Zemagho, Lise, Zent, Egleé L., and Zent, Stanford

Published
2024
Full Text
View/download PDF

39. Evidence for a Compact Object in the Aftermath of the Extra-Galactic Transient AT2018cow

Author

Pasham, Dheeraj R., Ho, Wynn C. G., Alston, William, Remillard, Ronald, Ng, Mason, Gendreau, Keith, Metzger, Brian D., Altamirano, Diego, Chakrabarty, Deepto, Fabian, Andrew, Miller, Jon, Bult, Peter, Arzoumanian, Zaven, Steiner, James F., Strohmayer, Tod, Tombesi, Francesco, Homan, Jeroen, Cackett, Edward M., and Harding, Alice

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The brightest Fast Blue Optical Transients (FBOTs) are mysterious extragalactic explosions that may represent a new class of astrophysical phenomena. Their fast time to maximum brightness of less than a week and decline over several months and atypical optical spectra and evolution are difficult to explain within the context of core-collapse of massive stars which are powered by radioactive decay of Nickel-56 and evolve more slowly. AT2018cow (at redshift of 0.014) is an extreme FBOT in terms of rapid evolution and high luminosities. Here we present evidence for a high-amplitude quasi-periodic oscillation (QPO) of AT2018cow's soft X-rays with a frequency of 224 Hz (at 3.7$\sigma$ significance level or false alarm probability of 0.02%) and fractional root-mean-squared amplitude of >30%. This signal is found in the average power density spectrum taken over the entire 60-day outburst and suggests a highly persistent signal that lasts for a billion cycles. The high frequency (rapid timescale) of 224 Hz (4.4 ms) argues for a compact object in AT2018cow, which can be a neutron star or black hole with a mass less than 850 solar masses. If the QPO is the spin period of a neutron star, we can set limits on the star's magnetic field strength. Our work highlights a new way of using high time-resolution X-ray observations to study FBOTs., Comment: Published in Nature astronomy on 13th December 2021

Published
2021
Full Text
View/download PDF

40. A NICER look at thermonuclear X-ray bursts from Aql X-1

Author

Guver, Tolga, Boztepe, Tugba, Ballantyne, David R., Bostanci, Z. Funda, Bult, Peter, Jaisawal, Gaurava K., Gogus, Ersin, Strohmayer, Tod E., Altamirano, Diego, Guillot, Sebastien, and Chakrabarty, Deepto

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We present spectral and temporal properties of all the thermonuclear X-ray bursts observed from Aql X-1 by the Neutron Star Interior and Composition Explorer (NICER) between 2017 July and 2021 April. This is the first systematic investigation of a large sample of type I X-ray bursts from Aql X-1 with improved sensitivity at low energies. We detect 22 X-ray bursts including two short recurrence burst events in which the separation was only 451 s and 496 s. We perform time resolved spectroscopy of the bursts using the fixed and scaled background (f_a method) approaches. We show that the use of a scaling factor to the pre-burst emission is the statistically preferred model in about 68% of all the spectra compared to the fixed background approach. Typically the f_a values are clustered around 1-3, but can reach up to 11 in a burst where photospheric radius expansion is observed. Such f_a values indicate a very significant increase in the pre-burst emission especially at around the peak flux moments of the bursts. We show that the use of the f_a factor alters the best fit spectral parameters of the burst emission. Finally, we employed a reflection model instead of scaling the pre-burst emission. We show that reflection models also do fit the spectra and improve the goodness of the fits. In all cases we see that the disc is highly ionized by the burst emission and the fraction of the reprocessed emission to the incident burst flux is typically clustered around 20%., Comment: Accepted for publication in Monthly Notices of the Royal Astronomical Society

Published
2021
Full Text
View/download PDF

43. The Effect of Post‐Treatment Combined Lifestyle Interventions on Quality of Life in Colorectal Cancer Patients – A Systematic Review

Author

Anke H. C. Gielen, Britt J. M. Thomassen, Tim J. Bult, Jarno Melenhorst, Merel L. Kimman, and Stephanie O. Breukink

Subjects
colorectal cancer, combined lifestyle interventions, quality of life, Public aspects of medicine, RA1-1270
Abstract

ABSTRACT Background Colorectal cancer is identified as a lifestyle‐related type of cancer. There is an increasing emphasis on lifestyle interventions targeting pivotal lifestyle factors such as excess weight, cigarette smoking, alcohol consumption, poor diet and physical inactivity as primary and tertiary prevention. Furthermore, modifying these lifestyle factors has the potential to improve quality of life for cancer patients. We aim to identify, appraise and synthesise the available evidence regarding the effect of combined lifestyle interventions on quality of life in colorectal cancer survivors. Methods Pubmed, Ovid Embase and the Cochrane Library were searched for studies reporting on quality of life in post‐treatment colorectal cancer patients. The systematic literature search was performed according to the Preferred Reporting Items for systematic reviews and meta‐analysis (PRISMA) guidelines. Results Five articles reporting on 719 individual patients were included. Two studies reported significantly better results in (cancer‐specific) quality‐of‐life questionnaires for patients after combined lifestyle interventions. Conclusion We conclude that there is some evidence that combined lifestyle interventions could have beneficial effects on the quality of life of colorectal cancer survivors. Future randomised controlled trials reporting on quality of life of combined lifestyle interventions in colorectal cancer survivors are warranted.

Published
2024
Full Text
View/download PDF

44. Search for continuous gravitational waves from 20 accreting millisecond X-ray pulsars in O3 LIGO data

Author

The LIGO Scientific Collaboration, the Virgo Collaboration, the KAGRA Collaboration, Abbott, R., Abbott, T. D., Acernese, F., Ackley, K., Adams, C., Adhikari, N., Adhikari, R. X., Adya, V. B., Affeldt, C., Agarwal, D., Agathos, M., Agatsuma, K., Aggarwal, N., Aguiar, O. D., Aiello, L., Ain, A., Akutsu, T., Albanesi, S., Allocca, A., Altin, P. A., Amato, A., Anand, C., Anand, S., Ananyeva, A., Anderson, S. B., Anderson, W. G., Ando, M., Andrade, T., Andres, N., Andrić, T., Angelova, S. V., Ansoldi, S., Antelis, J. M., Antier, S., Appert, S., Arai, Koji, Arai, Koya, Arai, Y., Araki, S., Araya, A., Araya, M. C., Areeda, J. S., Arène, M., Aritomi, N., Arnaud, N., Aronson, S. M., Arun, K. G., Asada, H., Asali, Y., Ashton, G., Aso, Y., Assiduo, M., Aston, S. M., Astone, P., Aubin, F., Austin, C., Babak, S., Badaracco, F., Bader, M. K. M., Badger, C., Bae, S., Bae, Y., Baer, A. M., Bagnasco, S., Bai, Y., Baiotti, L., Baird, J., Bajpai, R., Ball, M., Ballardin, G., Ballmer, S. W., Balsamo, A., Baltus, G., Banagiri, S., Bankar, D., Barayoga, J. C., Barbieri, C., Barish, B. C., Barker, D., Barneo, P., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartlett, J., Barton, M. A., Bartos, I., Bassiri, R., Basti, A., Bawaj, M., Bayley, J. C., Baylor, A. C., Bazzan, M., Bécsy, B., Bedakihale, V. M., Bejger, M., Belahcene, I., Benedetto, V., Beniwal, D., Bennett, T. F., Bentley, J. D., BenYaala, M., Bergamin, F., Berger, B. K., Bernuzzi, S., Bersanetti, D., Bertolini, A., Betzwieser, J., Beveridge, D., Bhandare, R., Bhardwaj, U., Bhattacharjee, D., Bhaumik, S., Bilenko, I. A., Billingsley, G., Bini, S., Birney, R., Birnholtz, O., Biscans, S., Bischi, M., Biscoveanu, S., Bisht, A., Biswas, B., Bitossi, M., Bizouard, M. -A., Blackburn, J. K., Blair, C. D., Blair, D. G., Blair, R. M., Bobba, F., Bode, N., Boer, M., Bogaert, G., Boldrini, M., Bonavena, L. D., Bondu, F., Bonilla, E., Bonnand, R., Booker, P., Boom, B. A., Bork, R., Boschi, V., Bose, N., Bose, S., Bossilkov, V., Boudart, V., Bouffanais, Y., Bozzi, A., Bradaschia, C., Brady, P. R., Bramley, A., Branch, A., Branchesi, M., Brau, J. E., Breschi, M., Briant, T., Briggs, J. H., Brillet, A., Brinkmann, M., Brockill, P., Brooks, A. F., Brooks, J., Brown, D. D., Brunett, S., Bruno, G., Bruntz, R., Bryant, J., Bulik, T., Bulten, H. J., Buonanno, A., Buscicchio, R., Buskulic, D., Buy, C., Byer, R. L., Cadonati, L., Cagnoli, G., Cahillane, C., Bustillo, J. Calderón, Callaghan, J. D., Callister, T. A., Calloni, E., Cameron, J., Camp, J. B., Canepa, M., Canevarolo, S., Cannavacciuolo, M., Cannon, K. C., Cao, H., Cao, Z., Capocasa, E., Capote, E., Carapella, G., Carbognani, F., Carlin, J. B., Carney, M. F., Carpinelli, M., Carrillo, G., Carullo, G., Carver, T. L., Diaz, J. Casanueva, Casentini, C., Castaldi, G., Caudill, S., Cavaglià, M., Cavalier, F., Cavalieri, R., Ceasar, M., Cella, G., Cerdá-Durán, P., Cesarini, E., Chaibi, W., Chakravarti, K., Subrahmanya, S. Chalathadka, Champion, E., Chan, C. -H., Chan, C., Chan, C. L., Chan, K., Chan, M., Chandra, K., Chanial, P., Chao, S., Charlton, P., Chase, E. A., Chassande-Mottin, E., Chatterjee, C., Chatterjee, Debarati, Chatterjee, Deep, Chaturvedi, M., Chaty, S., Chen, C., Chen, H. Y., Chen, J., Chen, K., Chen, X., Chen, Y. -B., Chen, Y. -R., Chen, Z., Cheng, H., Cheong, C. K., Cheung, H. Y., Chia, H. Y., Chiadini, F., Chiang, C-Y., Chiarini, G., Chierici, R., Chincarini, A., Chiofalo, M. L., Chiummo, A., Cho, G., Cho, H. S., Choudhary, R. K., Choudhary, S., Christensen, N., Chu, H., Chu, Q., Chu, Y-K., Chua, S., Chung, K. W., Ciani, G., Ciecielag, P., Cieślar, M., Cifaldi, M., Ciobanu, A. A., Ciolfi, R., Cipriano, F., Cirone, A., Clara, F., Clark, E. N., Clark, J. A., Clarke, L., Clearwater, P., Clesse, S., Cleva, F., Coccia, E., Codazzo, E., Cohadon, P. -F., Cohen, D. E., Cohen, L., Colleoni, M., Collette, C. G., Colombo, A., Colpi, M., Compton, C. M., Constancio Jr., M., Conti, L., Cooper, S. J., Corban, P., Corbitt, T. R., Cordero-Carrión, I., Corezzi, S., Corley, K. R., Cornish, N., Corre, D., Corsi, A., Cortese, S., Costa, C. A., Cotesta, R., Coughlin, M. W., Coulon, J. -P., Countryman, S. T., Cousins, B., Couvares, P., Coward, D. M., Cowart, M. J., Coyne, D. C., Coyne, R., Creighton, J. D. E., Creighton, T. D., Criswell, A. W., Croquette, M., Crowder, S. G., Cudell, J. R., Cullen, T. J., Cumming, A., Cummings, R., Cunningham, L., Cuoco, E., Curyło, M., Dabadie, P., Canton, T. Dal, Dall'Osso, S., Dálya, G., Dana, A., DaneshgaranBajastani, L. M., D'Angelo, B., Danilishin, S., D'Antonio, S., Danzmann, K., Darsow-Fromm, C., Dasgupta, A., Datrier, L. E. H., Datta, S., Dattilo, V., Dave, I., Davier, M., Davies, G. S., Davis, D., Davis, M. C., Daw, E. J., Dean, R., DeBra, D., Deenadayalan, M., Degallaix, J., De Laurentis, M., Deléglise, S., Del Favero, V., De Lillo, F., De Lillo, N., Del Pozzo, W., DeMarchi, L. M., De Matteis, F., D'Emilio, V., Demos, N., Dent, T., Depasse, A., De Pietri, R., De Rosa, R., De Rossi, C., DeSalvo, R., De Simone, R., Dhurandhar, S., Díaz, M. C., Diaz-Ortiz Jr., M., Didio, N. A., Dietrich, T., Di Fiore, L., Di Fronzo, C., Di Giorgio, C., Di Giovanni, F., Di Giovanni, M., Di Girolamo, T., Di Lieto, A., Ding, B., Di Pace, S., Di Palma, I., Di Renzo, F., Divakarla, A. K., Dmitriev, A., Doctor, Z., D'Onofrio, L., Donovan, F., Dooley, K. L., Doravari, S., Dorrington, I., Drago, M., Driggers, J. C., Drori, Y., Ducoin, J. -G., Dupej, P., Durante, O., D'Urso, D., Duverne, P. -A., Dwyer, S. E., Eassa, C., Easter, P. J., Ebersold, M., Eckhardt, T., Eddolls, G., Edelman, B., Edo, T. B., Edy, O., Effler, A., Eguchi, S., Eichholz, J., Eikenberry, S. S., Eisenmann, M., Eisenstein, R. A., Ejlli, A., Engelby, E., Enomoto, Y., Errico, L., Essick, R. C., Estellés, H., Estevez, D., Etienne, Z., Etzel, T., Evans, M., Evans, T. M., Ewing, B. E., Fafone, V., Fair, H., Fairhurst, S., Farah, A. M., Farinon, S., Farr, B., Farr, W. M., Farrow, N. W., Fauchon-Jones, E. J., Favaro, G., Favata, M., Fays, M., Fazio, M., Feicht, J., Fejer, M. M., Fenyvesi, E., Ferguson, D. L., Fernandez-Galiana, A., Ferrante, I., Ferreira, T. A., Fidecaro, F., Figura, P., Fiori, I., Fishbach, M., Fisher, R. P., Fittipaldi, R., Fiumara, V., Flaminio, R., Floden, E., Fong, H., Font, J. A., Fornal, B., Forsyth, P. W. F., Franke, A., Frasca, S., Frasconi, F., Frederick, C., Freed, J. P., Frei, Z., Freise, A., Frey, R., Fritschel, P., Frolov, V. V., Fronzé, G. G., Fujii, Y., Fujikawa, Y., Fukunaga, M., Fukushima, M., Fulda, P., Fyffe, M., Gabbard, H. A., Gadre, B. U., Gair, J. R., Gais, J., Galaudage, S., Gamba, R., Ganapathy, D., Ganguly, A., Gao, D., Gaonkar, S. G., Garaventa, B., García-Núñez, C., García-Quirós, C., Garufi, F., Gateley, B., Gaudio, S., Gayathri, V., Ge, G. -G., Gemme, G., Gennai, A., George, J., Gerberding, O., Gergely, L., Gewecke, P., Ghonge, S., Ghosh, Abhirup, Ghosh, Archisman, Ghosh, Shaon, Ghosh, Shrobana, Giacomazzo, B., Giacoppo, L., Giaime, J. A., Giardina, K. D., Gibson, D. R., Gier, C., Giesler, M., Giri, P., Gissi, F., Glanzer, J., Gleckl, A. E., Godwin, P., Goetz, E., Goetz, R., Gohlke, N., Goncharov, B., González, G., Gopakumar, A., Gosselin, M., Gouaty, R., Gould, D. W., Grace, B., Grado, A., Granata, M., Granata, V., Grant, A., Gras, S., Grassia, P., Gray, C., Gray, R., Greco, G., Green, A. C., Green, R., Gretarsson, A. M., Gretarsson, E. M., Griffith, D., Griffiths, W., Griggs, H. L., Grignani, G., Grimaldi, A., Grimm, S. J., Grote, H., Grunewald, S., Gruning, P., Guerra, D., Guidi, G. M., Guimaraes, A. R., Guixé, G., Gulati, H. K., Guo, H. -K., Guo, Y., Gupta, Anchal, Gupta, Anuradha, Gupta, P., Gustafson, E. K., Gustafson, R., Guzman, F., Ha, S., Haegel, L., Hagiwara, A., Haino, S., Halim, O., Hall, E. D., Hamilton, E. Z., Hammond, G., Han, W. -B., Haney, M., Hanks, J., Hanna, C., Hannam, M. D., Hannuksela, O., Hansen, H., Hansen, T. J., Hanson, J., Harder, T., Hardwick, T., Haris, K., Harms, J., Harry, G. M., Harry, I. W., Hartwig, D., Hasegawa, K., Haskell, B., Hasskew, R. K., Haster, C. -J., Hattori, K., Haughian, K., Hayakawa, H., Hayama, K., Hayes, F. J., Healy, J., Heidmann, A., Heidt, A., Heintze, M. C., Heinze, J., Heinzel, J., Heitmann, H., Hellman, F., Hello, P., Helmling-Cornell, A. F., Hemming, G., Hendry, M., Heng, I. S., Hennes, E., Hennig, J., Hennig, M. H., Hernandez, A. G., Vivanco, F. Hernandez, Heurs, M., Hild, S., Hill, P., Himemoto, Y., Hines, A. S., Hiranuma, Y., Hirata, N., Hirose, E., Ho, W. C. G., Hochheim, S., Hofman, D., Hohmann, J. N., Holcomb, D. G., Holland, N. A., Hollows, I. J., Holmes, Z. J., Holt, K., Holz, D. E., Hong, Z., Hopkins, P., Hough, J., Hourihane, S., Howell, E. J., Hoy, C. G., Hoyland, D., Hreibi, A., Hsieh, B-H., Hsu, Y., Huang, G-Z., Huang, H-Y., Huang, P., Huang, Y-C., Huang, Y. -J., Huang, Y., Hübner, M. T., Huddart, A. D., Hughey, B., Hui, D. C. Y., Hui, V., Husa, S., Huttner, S. H., Huxford, R., Huynh-Dinh, T., Ide, S., Idzkowski, B., Iess, A., Ikenoue, B., Imam, S., Inayoshi, K., Ingram, C., Inoue, Y., Ioka, K., Isi, M., Isleif, K., Ito, K., Itoh, Y., Iyer, B. R., Izumi, K., JaberianHamedan, V., Jacqmin, T., Jadhav, S. J., Jadhav, S. P., James, A. L., Jan, A. Z., Jani, K., Janquart, J., Janssens, K., Janthalur, N. N., Jaranowski, P., Jariwala, D., Jaume, R., Jenkins, A. C., Jenner, K., Jeon, C., Jeunon, M., Jia, W., Jin, H. -B., Johns, G. R., Jones, A. W., Jones, D. I., Jones, J. D., Jones, P., Jones, R., Jonker, R. J. G., Ju, L., Jung, P., Jung, K., Junker, J., Juste, V., Kaihotsu, K., Kajita, T., Kakizaki, M., Kalaghatgi, C. V., Kalogera, V., Kamai, B., Kamiizumi, M., Kanda, N., Kandhasamy, S., Kang, G., Kanner, J. B., Kao, Y., Kapadia, S. J., Kapasi, D. P., Karat, S., Karathanasis, C., Karki, S., Kashyap, R., Kasprzack, M., Kastaun, W., Katsanevas, S., Katsavounidis, E., Katzman, W., Kaur, T., Kawabe, K., Kawaguchi, K., Kawai, N., Kawasaki, T., Kéfélian, F., Keitel, D., Key, J. S., Khadka, S., Khalili, F. Y., Khan, S., Khazanov, E. A., Khetan, N., Khursheed, M., Kijbunchoo, N., Kim, C., Kim, J. C., Kim, J., Kim, K., Kim, W. S., Kim, Y. -M., Kimball, C., Kimura, N., Kinley-Hanlon, M., Kirchhoff, R., Kissel, J. S., Kita, N., Kitazawa, H., Kleybolte, L., Klimenko, S., Knee, A. M., Knowles, T. D., Knyazev, E., Koch, P., Koekoek, G., Kojima, Y., Kokeyama, K., Koley, S., Kolitsidou, P., Kolstein, M., Komori, K., Kondrashov, V., Kong, A. K. H., Kontos, A., Koper, N., Korobko, M., Kotake, K., Kovalam, M., Kozak, D. B., Kozakai, C., Kozu, R., Kringel, V., Krishnendu, N. V., Królak, A., Kuehn, G., Kuei, F., Kuijer, P., Kumar, A., Kumar, P., Kumar, Rahul, Kumar, Rakesh, Kume, J., Kuns, K., Kuo, C., Kuo, H-S., Kuromiya, Y., Kuroyanagi, S., Kusayanagi, K., Kuwahara, S., Kwak, K., Lagabbe, P., Laghi, D., Lalande, E., Lam, T. L., Lamberts, A., Landry, M., Lane, B. B., Lang, R. N., Lange, J., Lantz, B., La Rosa, I., Lartaux-Vollard, A., Lasky, P. D., Laxen, M., Lazzarini, A., Lazzaro, C., Leaci, P., Leavey, S., Lecoeuche, Y. K., Lee, H. K., Lee, H. M., Lee, H. W., Lee, J., Lee, K., Lee, R., Lehmann, J., Lemaître, A., Leonardi, M., Leroy, N., Letendre, N., Levesque, C., Levin, Y., Leviton, J. N., Leyde, K., Li, A. K. Y., Li, B., Li, J., Li, K. L., Li, T. G. F., Li, X., Lin, C-Y., Lin, F-K., Lin, F-L., Lin, H. L., Lin, L. C. -C., Linde, F., Linker, S. D., Linley, J. N., Littenberg, T. B., Liu, G. C., Liu, J., Liu, K., Liu, X., Llamas, F., Llorens-Monteagudo, M., Lo, R. K. L., Lockwood, A., London, L. T., Longo, A., Lopez, D., Portilla, M. Lopez, Lorenzini, M., Loriette, V., Lormand, M., Losurdo, G., Lott, T. P., Lough, J. D., Lousto, C. O., Lovelace, G., Lucaccioni, J. F., Lück, H., Lumaca, D., Lundgren, A. P., Luo, L. -W., Lynam, J. E., Macas, R., MacInnis, M., Macleod, D. M., MacMillan, I. A. O., Macquet, A., Hernandez, I. Magaña, Magazzù, C., Magee, R. M., Maggiore, R., Magnozzi, M., Mahesh, S., Majorana, E., Makarem, C., Maksimovic, I., Maliakal, S., Malik, A., Man, N., Mandic, V., Mangano, V., Mango, J. L., Mansell, G. L., Manske, M., Mantovani, M., Mapelli, M., Marchesoni, F., Marchio, M., Marion, F., Mark, Z., Márka, S., Márka, Z., Markakis, C., Markosyan, A. S., Markowitz, A., Maros, E., Marquina, A., Marsat, S., Martelli, F., Martin, I. W., Martin, R. M., Martinez, M., Martinez, V. A., Martinez, V., Martinovic, K., Martynov, D. V., Marx, E. J., Masalehdan, H., Mason, K., Massera, E., Masserot, A., Massinger, T. J., Masso-Reid, M., Mastrogiovanni, S., Matas, A., Mateu-Lucena, M., Matichard, F., Matiushechkina, M., Mavalvala, N., McCann, J. J., McCarthy, R., McClelland, D. E., McClincy, P. K., McCormick, S., McCuller, L., McGhee, G. I., McGuire, S. C., McIsaac, C., McIver, J., McRae, T., McWilliams, S. T., Meacher, D., Mehmet, M., Mehta, A. K., Meijer, Q., Melatos, A., Melchor, D. A., Mendell, G., Menendez-Vazquez, A., Menoni, C. S., Mercer, R. A., Mereni, L., Merfeld, K., Merilh, E. L., Merritt, J. D., Merzougui, M., Meshkov, S., Messenger, C., Messick, C., Meyers, P. M., Meylahn, F., Mhaske, A., Miani, A., Miao, H., Michaloliakos, I., Michel, C., Michimura, Y., Middleton, H., Milano, L., Miller, A. L., Miller, A., Miller, B., Millhouse, M., Mills, J. C., Milotti, E., Minazzoli, O., Minenkov, Y., Mio, N., Mir, Ll. M., Miravet-Tenés, M., Mishra, C., Mishra, T., Mistry, T., Mitra, S., Mitrofanov, V. P., Mitselmakher, G., Mittleman, R., Miyakawa, O., Miyamoto, A., Miyazaki, Y., Miyo, K., Miyoki, S., Mo, Geoffrey, Moguel, E., Mogushi, K., Mohapatra, S. R. P., Mohite, S. R., Molina, I., Molina-Ruiz, M., Mondin, M., Montani, M., Moore, C. J., Moraru, D., Morawski, F., More, A., Moreno, C., Moreno, G., Mori, Y., Morisaki, S., Moriwaki, Y., Mours, B., Mow-Lowry, C. M., Mozzon, S., Muciaccia, F., Mukherjee, Arunava, Mukherjee, D., Mukherjee, Soma, Mukherjee, Subroto, Mukherjee, Suvodip, Mukund, N., Mullavey, A., Munch, J., Muñiz, E. A., Murray, P. G., Musenich, R., Muusse, S., Nadji, S. L., Nagano, K., Nagano, S., Nagar, A., Nakamura, K., Nakano, H., Nakano, M., Nakashima, R., Nakayama, Y., Napolano, V., Nardecchia, I., Narikawa, T., Naticchioni, L., Nayak, B., Nayak, R. K., Negishi, R., Neil, B. F., Neilson, J., Nelemans, G., Nelson, T. J. N., Nery, M., Neubauer, P., Neunzert, A., Ng, K. Y., Ng, S. W. S., Nguyen, C., Nguyen, P., Nguyen, T., Quynh, L. Nguyen, Ni, W. -T., Nichols, S. A., Nishizawa, A., Nissanke, S., Nitoglia, E., Nocera, F., Norman, M., North, C., Nozaki, S., Nuttall, L. K., Oberling, J., O'Brien, B. D., Obuchi, Y., O'Dell, J., Oelker, E., Ogaki, W., Oganesyan, G., Oh, J. J., Oh, K., Oh, S. H., Ohashi, M., Ohishi, N., Ohkawa, M., Ohme, F., Ohta, H., Okada, M. A., Okutani, Y., Okutomi, K., Olivetto, C., Oohara, K., Ooi, C., Oram, R., O'Reilly, B., Ormiston, R. G., Ormsby, N. D., Ortega, L. F., O'Shaughnessy, R., O'Shea, E., Oshino, S., Ossokine, S., Osthelder, C., Otabe, S., Ottaway, D. J., Overmier, H., Pace, A. E., Pagano, G., Page, M. A., Pagliaroli, G., Pai, A., Pai, S. A., Palamos, J. R., Palashov, O., Palomba, C., Pan, H., Pan, K., Panda, P. K., Pang, H., Pang, P. T. H., Pankow, C., Pannarale, F., Pant, B. C., Panther, F. H., Paoletti, F., Paoli, A., Paolone, A., Parisi, A., Park, H., Park, J., Parker, W., Pascucci, D., Pasqualetti, A., Passaquieti, R., Passuello, D., Patel, M., Pathak, M., Patricelli, B., Patron, A. S., Patrone, S., Paul, S., Payne, E., Pedraza, M., Pegoraro, M., Pele, A., Arellano, F. E. Peña, Penn, S., Perego, A., Pereira, A., Pereira, T., Perez, C. J., Périgois, C., Perkins, C. C., Perreca, A., Perriès, S., Petermann, J., Petterson, D., Pfeiffer, H. P., Pham, K. A., Phukon, K. S., Piccinni, O. J., Pichot, M., Piendibene, M., Piergiovanni, F., Pierini, L., Pierro, V., Pillant, G., Pillas, M., Pilo, F., Pinard, L., Pinto, I. M., Pinto, M., Piotrzkowski, K., Pirello, M., Pitkin, M. D., Placidi, E., Planas, L., Plastino, W., Pluchar, C., Poggiani, R., Polini, E., Pong, D. Y. T., Ponrathnam, S., Popolizio, P., Porter, E. K., Poulton, R., Powell, J., Pracchia, M., Pradier, T., Prajapati, A. K., Prasai, K., Prasanna, R., Pratten, G., Principe, M., Prodi, G. A., Prokhorov, L., Prosposito, P., Prudenzi, L., Puecher, A., Punturo, M., Puosi, F., Puppo, P., Pürrer, M., Qi, H., Quetschke, V., Quitzow-James, R., Raab, F. J., Raaijmakers, G., Radkins, H., Radulesco, N., Raffai, P., Rail, S. X., Raja, S., Rajan, C., Ramirez, K. E., Ramirez, T. D., Ramos-Buades, A., Rana, J., Rapagnani, P., Rapol, U. D., Ray, A., Raymond, V., Raza, N., Razzano, M., Read, J., Rees, L. A., Regimbau, T., Rei, L., Reid, S., Reid, S. W., Reitze, D. H., Relton, P., Renzini, A., Rettegno, P., Rezac, M., Ricci, F., Richards, D., Richardson, J. W., Richardson, L., Riemenschneider, G., Riles, K., Rinaldi, S., Rink, K., Rizzo, M., Robertson, N. A., Robie, R., Robinet, F., Rocchi, A., Rodriguez, S., Rolland, L., Rollins, J. G., Romanelli, M., Romano, R., Romel, C. L., Romero-Rodríguez, A., Romero-Shaw, I. M., Romie, J. H., Ronchini, S., Rosa, L., Rose, C. A., Rosińska, D., Ross, M. P., Rowan, S., Rowlinson, S. J., Roy, S., Roy, Santosh, Roy, Soumen, Rozza, D., Ruggi, P., Ryan, K., Sachdev, S., Sadecki, T., Sadiq, J., Sago, N., Saito, S., Saito, Y., Sakai, K., Sakai, Y., Sakellariadou, M., Sakuno, Y., Salafia, O. S., Salconi, L., Saleem, M., Salemi, F., Samajdar, A., Sanchez, E. J., Sanchez, J. H., Sanchez, L. E., Sanchis-Gual, N., Sanders, J. R., Sanuy, A., Saravanan, T. R., Sarin, N., Sassolas, B., Satari, H., Sato, S., Sato, T., Sauter, O., Savage, R. L., Sawada, T., Sawant, D., Sawant, H. L., Sayah, S., Schaetzl, D., Scheel, M., Scheuer, J., Schiworski, M., Schmidt, P., Schmidt, S., Schnabel, R., Schneewind, M., Schofield, R. M. S., Schönbeck, A., Schulte, B. W., Schutz, B. F., Schwartz, E., Scott, J., Scott, S. M., Seglar-Arroyo, M., Sekiguchi, T., Sekiguchi, Y., Sellers, D., Sengupta, A. S., Sentenac, D., Seo, E. G., Sequino, V., Sergeev, A., Setyawati, Y., Shaffer, T., Shahriar, M. S., Shams, B., Shao, L., Sharma, A., Sharma, P., Shawhan, P., Shcheblanov, N. S., Shibagaki, S., Shikauchi, M., Shimizu, R., Shimoda, T., Shimode, K., Shinkai, H., Shishido, T., Shoda, A., Shoemaker, D. H., Shoemaker, D. M., ShyamSundar, S., Sieniawska, M., Sigg, D., Singer, L. P., Singh, D., Singh, N., Singha, A., Sintes, A. M., Sipala, V., Skliris, V., Slagmolen, B. J. J., Slaven-Blair, T. J., Smetana, J., Smith, J. R., Smith, R. J. E., Soldateschi, J., Somala, S. N., Somiya, K., Son, E. J., Soni, K., Soni, S., Sordini, V., Sorrentino, F., Sorrentino, N., Sotani, H., Soulard, R., Souradeep, T., Sowell, E., Spagnuolo, V., Spencer, A. P., Spera, M., Srinivasan, R., Srivastava, A. K., Srivastava, V., Staats, K., Stachie, C., Steer, D. A., Steinlechner, J., Steinlechner, S., Stops, D. J., Stover, M., Strain, K. A., Strang, L. C., Stratta, G., Strunk, A., Sturani, R., Stuver, A. L., Sudhagar, S., Sudhir, V., Sugimoto, R., Suh, H. G., Summerscales, T. Z., Sun, H., Sun, L., Sunil, S., Sur, A., Suresh, J., Sutton, P. J., Suzuki, Takamasa, Suzuki, Toshikazu, Swinkels, B. L., Szczepańczyk, M. J., Szewczyk, P., Tacca, M., Tagoshi, H., Tait, S. C., Takahashi, H., Takahashi, R., Takamori, A., Takano, S., Takeda, H., Takeda, M., Talbot, C. J., Talbot, C., Tanaka, H., Tanaka, Kazuyuki, Tanaka, Kenta, Tanaka, Taiki, Tanaka, Takahiro, Tanasijczuk, A. J., Tanioka, S., Tanner, D. B., Tao, D., Tao, L., Martín, E. N. Tapia San, Taranto, C., Tasson, J. D., Telada, S., Tenorio, R., Terhune, J. E., Terkowski, L., Thirugnanasambandam, M. P., Thomas, M., Thomas, P., Thompson, J. E., Thondapu, S. R., Thorne, K. A., Thrane, E., Tiwari, Shubhanshu, Tiwari, Srishti, Tiwari, V., Toivonen, A. M., Toland, K., Tolley, A. E., Tomaru, T., Tomigami, Y., Tomura, T., Tonelli, M., Torres-Forné, A., Torrie, C. I., Melo, I. Tosta e, Töyrä, D., Trapananti, A., Travasso, F., Traylor, G., Trevor, M., Tringali, M. C., Tripathee, A., Troiano, L., Trovato, A., Trozzo, L., Trudeau, R. J., Tsai, D. S., Tsai, D., Tsang, K. W., Tsang, T., Tsao, J-S., Tse, M., Tso, R., Tsubono, K., Tsuchida, S., Tsukada, L., Tsuna, D., Tsutsui, T., Tsuzuki, T., Turbang, K., Turconi, M., Tuyenbayev, D., Ubhi, A. S., Uchikata, N., Uchiyama, T., Udall, R. P., Ueda, A., Uehara, T., Ueno, K., Ueshima, G., Unnikrishnan, C. S., Uraguchi, F., Urban, A. L., Ushiba, T., Utina, A., Vahlbruch, H., Vajente, G., Vajpeyi, A., Valdes, G., Valentini, M., Valsan, V., van Bakel, N., van Beuzekom, M., Brand, J. F. J. van den, Broeck, C. Van Den, Vander-Hyde, D. C., van der Schaaf, L., van Heijningen, J. V., Vanosky, J., van Putten, M. H. P. M., van Remortel, N., Vardaro, M., Vargas, A. F., Varma, V., Vasúth, M., Vecchio, A., Vedovato, G., Veitch, J., Veitch, P. J., Venneberg, J., Venugopalan, G., Verkindt, D., Verma, P., Verma, Y., Veske, D., Vetrano, F., Viceré, A., Vidyant, S., Viets, A. D., Vijaykumar, A., Villa-Ortega, V., Vinet, J. -Y., Virtuoso, A., Vitale, S., Vo, T., Vocca, H., von Reis, E. R. G., von Wrangel, J. S. A., Vorvick, C., Vyatchanin, S. P., Wade, L. E., Wade, M., Wagner, K. J., Walet, R. C., Walker, M., Wallace, G. S., Wallace, L., Walsh, S., Wang, J., Wang, J. Z., Wang, W. H., Ward, R. L., Warner, J., Was, M., Washimi, T., Washington, N. Y., Watchi, J., Weaver, B., Webster, S. A., Weinert, M., Weinstein, A. J., Weiss, R., Weller, C. M., Wellmann, F., Wen, L., Weßels, P., Wette, K., Whelan, J. T., White, D. D., Whiting, B. F., Whittle, C., Wilken, D., Williams, D., Williams, M. J., Williamson, A. R., Willis, J. L., Willke, B., Wilson, D. J., Winkler, W., Wipf, C. C., Wlodarczyk, T., Woan, G., Woehler, J., Wofford, J. K., Wong, I. C. F., Wu, C., Wu, D. S., Wu, H., Wu, S., Wysocki, D. M., Xiao, L., Xu, W-R., Yamada, T., Yamamoto, H., Yamamoto, Kazuhiro, Yamamoto, Kohei, Yamamoto, T., Yamashita, K., Yamazaki, R., Yang, F. W., Yang, L., Yang, Y., Yang, Yang, Yang, Z., Yap, M. J., Yeeles, D. W., Yelikar, A. B., Ying, M., Yokogawa, K., Yokoyama, J., Yokozawa, T., Yoo, J., Yoshioka, T., Yu, Hang, Yu, Haocun, Yuzurihara, H., Zadrożny, A., Zanolin, M., Zeidler, S., Zelenova, T., Zendri, J. -P., Zevin, M., Zhan, M., Zhang, H., Zhang, J., Zhang, L., Zhang, T., Zhang, Y., Zhao, C., Zhao, G., Zhao, Y., Zhao, Yue, Zhou, R., Zhou, Z., Zhu, X. J., Zhu, Z. -H., Zucker, M. E., Zweizig, J., Albayati, A. C., Altamirano, D., Bult, P., Chakrabarty, D., Ng, M., Ray, P. S., Sanna, A., and Strohmayer, T. E.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, General Relativity and Quantum Cosmology
Abstract

Results are presented of searches for continuous gravitational waves from 20 accreting millisecond X-ray pulsars with accurately measured spin frequencies and orbital parameters, using data from the third observing run of the Advanced LIGO and Advanced Virgo detectors. The search algorithm uses a hidden Markov model, where the transition probabilities allow the frequency to wander according to an unbiased random walk, while the $\mathcal{J}$-statistic maximum-likelihood matched filter tracks the binary orbital phase. Three narrow sub-bands are searched for each target, centered on harmonics of the measured spin frequency. The search yields 16 candidates, consistent with a false alarm probability of 30% per sub-band and target searched. These candidates, along with one candidate from an additional target-of-opportunity search done for SAX J1808.4$-$3658, which was in outburst during one month of the observing run, cannot be confidently associated with a known noise source. Additional follow-up does not provide convincing evidence that any are a true astrophysical signal. When all candidates are assumed non-astrophysical, upper limits are set on the maximum wave strain detectable at 95% confidence, $h_0^{95\%}$. The strictest constraint is $h_0^{95\%} = 4.7\times 10^{-26}$ from IGR J17062$-$6143. Constraints on the detectable wave strain from each target lead to constraints on neutron star ellipticity and $r$-mode amplitude, the strictest of which are $\epsilon^{95\%} = 3.1\times 10^{-7}$ and $\alpha^{95\%} = 1.8\times 10^{-5}$ respectively. This analysis is the most comprehensive and sensitive search of continuous gravitational waves from accreting millisecond X-ray pulsars to date., Comment: 40 pages, 6 figures. This version contains minor typographical revisions to match published article

Published
2021
Full Text
View/download PDF

45. The stochastic X-ray variability of the accreting millisecond pulsar IGR J17062-6143

Author

Bult, Peter

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

This work presents an investigation of the stochastic X-ray variability from the 164 Hz accreting millisecond pulsar IGR J17062-6143, based on regular observations collected with the Neutron Star Interior Composition Explorer between 2017 July and 2020 August. Over this period, the power density spectrum showed a stable morphology, with broad $\sim25\%$ rms band-limited noise below 16 Hz. Quasi-periodic oscillations (QPOs) were occasionally observed, with the most notably detections including a low-frequency QPO centered at 2.7 Hz and a sharp QPO centered at 115 Hz that may be a 2:3 resonance with the spin frequency. Further, the energy dependence of the band-limited noise is studied through a spectroscopic analysis of the complex covariance in two frequency intervals. It is found that the power law continuum is the primary driver for the observed variability, although the thermal (blackbody) emission also appears to be intrinsically variable in area ($5\%$ rms) and temperature ($1\%$ rms). Notably, the 1 keV emission feature seen in all X-ray spectra of IGR J17062-6143 varies with the same amplitude as the power law, but systematically lags behind that continuum emission. These results appear consistent with a scenario in which a time variable Compton-scattering corona is the primary source for the observed stochastic variability, with the variability observed in the emission feature and at the lowest photon energies being due to the disk reflection of the power law continuum., Comment: 13 pages, 5 figures, 3 tables. Accepted for publication in ApJ

Published
2021
Full Text
View/download PDF

46. A MYC-rearrangement is a negative prognostic factor in stage II, but not in stage I diffuse large B-cell lymphoma

Author

A. V. de Jonge, J. A. A. Bult, D. F. E. Karssing, M. Nijland, M. E. D. Chamuleau, and M. Brink

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract MYC oncogene rearrangements (MYC-R) negatively affect survival in patients with Ann Arbor stage III–IV diffuse large B-cell lymphoma (DLBCL), but their impact in limited stage (LS) I–II is unclear. Therefore, we assessed the impact of MYC-R on progression-free survival (PFS) and overall survival (OS) in LS DLBCL patients at the population level. We identified 1,434 LS DLBCL patients with known MYC-R status diagnosed between 2014 and 2020, who received R-CHOP(-like) regimens using the Netherlands Cancer Registry, with survival follow-up until February 2022. Stage I patients with (n = 83, 11%) and without (n = 650, 89%) a MYC-R had similar 2-years PFS (89% and 93%, p = 0.63) and OS (both 95%, p = 0.22). Conversely, stage II DLBCL patients with a MYC-R (n = 90, 13%) had inferior survival outcomes compared to stage II patients without a MYC-R (n = 611, 87%) (PFS 70% vs. 89%, p = 0.001; OS 79% vs. 94%, p

Published
2024
Full Text
View/download PDF

47. Screening and diagnostic breast MRI: how do they impact surgical treatment? Insights from the MIPA study

Author

Cozzi, Andrea, Di Leo, Giovanni, Houssami, Nehmat, Gilbert, Fiona J., Helbich, Thomas H., Álvarez Benito, Marina, Balleyguier, Corinne, Bazzocchi, Massimo, Bult, Peter, Calabrese, Massimo, Camps Herrero, Julia, Cartia, Francesco, Cassano, Enrico, Clauser, Paola, de Lima Docema, Marcos F., Depretto, Catherine, Dominelli, Valeria, Forrai, Gábor, Girometti, Rossano, Harms, Steven E., Hilborne, Sarah, Ienzi, Raffaele, Lobbes, Marc B. I., Losio, Claudio, Mann, Ritse M., Montemezzi, Stefania, Obdeijn, Inge-Marie, Ozcan, Umit A., Pediconi, Federica, Pinker, Katja, Preibsch, Heike, Raya Povedano, José L., Rossi Saccarelli, Carolina, Sacchetto, Daniela, Scaperrotta, Gianfranco P., Schlooz, Margrethe, Szabó, Botond K., Taylor, Donna B., Ulus, Özden S., Van Goethem, Mireille, Veltman, Jeroen, Weigel, Stefanie, Wenkel, Evelyn, Zuiani, Chiara, and Sardanelli, Francesco

Published
2023
Full Text
View/download PDF

48. Harmonizing model organism data in the Alliance of Genome Resources

Author

Agapite, Julie, Albou, Laurent-Philippe, Aleksander, Suzanne A, Alexander, Micheal, Anagnostopoulos, Anna V, Antonazzo, Giulia, Argasinska, Joanna, Arnaboldi, Valerio, Attrill, Helen, Becerra, Andrés, Bello, Susan M, Blake, Judith A, Blodgett, Olin, Bradford, Yvonne M, Bult, Carol J, Cain, Scott, Calvi, Brian R, Carbon, Seth, Chan, Juancarlos, Chen, Wen J, Cherry, J Michael, Cho, Jaehyoung, Christie, Karen R, Crosby, Madeline A, Davis, Paul, da Veiga Beltrame, Eduardo, De Pons, Jeffrey L, D’Eustachio, Peter, Diamantakis, Stavros, Dolan, Mary E, dos Santos, Gilberto, Douglass, Eric, Dunn, Barbara, Eagle, Anne, Ebert, Dustin, Engel, Stacia R, Fashena, David, Foley, Saoirse, Frazer, Ken, Gao, Sibyl, Gibson, Adam C, Gondwe, Felix, Goodman, Josh, Gramates, L Sian, Grove, Christian A, Hale, Paul, Harris, Todd, Hayman, G Thomas, Hill, David P, Howe, Douglas G, Howe, Kevin L, Hu, Yanhui, Jha, Sagar, Kadin, James A, Kaufman, Thomas C, Kalita, Patrick, Karra, Kalpana, Kishore, Ranjana, Kwitek, Anne E, Laulederkind, Stanley JF, Lee, Raymond, Longden, Ian, Luypaert, Manuel, MacPherson, Kevin A, Martin, Ryan, Marygold, Steven J, Matthews, Beverley, McAndrews, Monica S, Millburn, Gillian, Miyasato, Stuart, Motenko, Howie, Moxon, Sierra, Muller, Hans-Michael, Mungall, Christopher J, Muruganujan, Anushya, Mushayahama, Tremayne, Nalabolu, Harika S, Nash, Robert S, Ng, Patrick, Nuin, Paulo, Paddock, Holly, Paulini, Michael, Perrimon, Norbert, Pich, Christian, Quinton-Tulloch, Mark, Raciti, Daniela, Ramachandran, Sridhar, Richardson, Joel E, Gelbart, Susan Russo, Ruzicka, Leyla, Schaper, Kevin, Schindelman, Gary, Shimoyama, Mary, Simison, Matt, Shaw, David R, Shrivatsav, Ajay, Singer, Amy, Skrzypek, Marek, Smith, Constance M, and Smith, Cynthia L

Subjects
Biological Sciences, Bioinformatics and Computational Biology, Genetics, Human Genome, Biotechnology, 1.5 Resources and infrastructure (underpinning), 1.1 Normal biological development and functioning, Generic health relevance, Alleles, Animals, Caenorhabditis elegans, Databases, Genetic, Drosophila, Gene Ontology, Humans, Internet, Mice, Molecular Sequence Annotation, Rats, Saccharomycetales, Zebrafish, Alliance of Genome Resources Consortium, biocuration, data mining, gene expression, gene function, gene interaction, genome, knowledgebase, phenotype, variants, Developmental Biology, Biochemistry and cell biology
Abstract

The Alliance of Genome Resources (the Alliance) is a combined effort of 7 knowledgebase projects: Saccharomyces Genome Database, WormBase, FlyBase, Mouse Genome Database, the Zebrafish Information Network, Rat Genome Database, and the Gene Ontology Resource. The Alliance seeks to provide several benefits: better service to the various communities served by these projects; a harmonized view of data for all biomedical researchers, bioinformaticians, clinicians, and students; and a more sustainable infrastructure. The Alliance has harmonized cross-organism data to provide useful comparative views of gene function, gene expression, and human disease relevance. The basis of the comparative views is shared calls of orthology relationships and the use of common ontologies. The key types of data are alleles and variants, gene function based on gene ontology annotations, phenotypes, association to human disease, gene expression, protein-protein and genetic interactions, and participation in pathways. The information is presented on uniform gene pages that allow facile summarization of information about each gene in each of the 7 organisms covered (budding yeast, roundworm Caenorhabditis elegans, fruit fly, house mouse, zebrafish, brown rat, and human). The harmonized knowledge is freely available on the alliancegenome.org portal, as downloadable files, and by APIs. We expect other existing and emerging knowledge bases to join in the effort to provide the union of useful data and features that each knowledge base currently provides.

Published
2022

49. On the impact of an intermediate duration X-ray burst on the accretion environment in IGR J17062-6143

Author

Bult, Peter, Altamirano, Diego, Arzoumanian, Zaven, Ballantyne, David R., Chenevez, Jerome, Fabian, Andrew C., Gendreau, Keith C., Homan, Jeroen, Jaisawal, Gaurava K., Malacaria, Christian, Miller, Jon M., Parker, Michael L., and Strohmayer, Tod E.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We report on a spectroscopic analysis of the X-ray emission from IGR J17062-6143 in the aftermath of its June 2020 intermediate duration Type I X-ray burst. Using the Neutron Star Interior Composition Explorer, we started observing the source three hours after the burst was detected with MAXI/GSC, and monitored the source for the subsequent twelve days. We observed the tail end of the X-ray burst cooling phase, and find that the X-ray flux is severely depressed relative to its historic value for a three day period directly following the burst. We interpret this intensity dip as the inner accretion disk gradually restoring itself after being perturbed by the burst irradiation. Superimposed on this trend we observed a $1.5$ d interval during which the X-ray flux is sharply lower than the wider trend. This drop in flux could be isolated to the non-thermal components in the energy spectrum, suggesting that it may be caused by an evolving corona. Additionally, we detected a 3.4 keV absorption line at $6.3\sigma$ significance in a single $472$ s observation while the burst emission was still bright. We tentatively identify the line as a gravitationally redshifted absorption line from burning ashes on the stellar surface, possibly associated with ${}^{40}{\rm Ca}$ or ${}^{44}{\rm Ti}$., Comment: 14 pages, 7 figures, 3 tables. Accepted for publication in ApJ

Published
2021
Full Text
View/download PDF

50. Dips and eclipses in the X-ray binary Swift J1858.6-0814 observed with NICER

Author

Buisson, D. J. K., Altamirano, D., Padilla, M. Armas, Arzoumanian, Z., Bult, P., Segura, N. Castro, Charles, P. A., Degenaar, N., Trigo, M. Díaz, Eijnden, J. van den, Fogantini, F., Gandhi, P., Gendreau, K., Hare, J., Homan, J., Knigge, C., Malacaria, C., Mendez, M., Darias, T. Muñoz, Ng, M., Arabacı, M. Özbey, Remillard, R., Strohmayer, T. E., Tombesi, F., Tomsick, J. A., Vincentelli, F., and Walton, D. J.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We present the discovery of eclipses in the X-ray light curves of the X-ray binary Swift J1858.6-0814. From these, we find an orbital period of $P=76841.3_{-1.4}^{+1.3}$ s ($\approx21.3$ hours) and an eclipse duration of $t_{\rm ec}=4098_{-18}^{+17}$ s ($\approx1.14$ hours). We also find several absorption dips during the pre-eclipse phase. From the eclipse duration to orbital period ratio, the inclination of the binary orbit is constrained to $i>70^\circ$. The most likely range for the companion mass suggests that the inclination is likely to be closer to this value than $90^\circ$. The eclipses are also consistent with earlier data, in which strong variability ('flares') and the long orbital period prevent clear detection of the period or eclipses. We also find that the bright flares occurred preferentially in the post-eclipse phase of the orbit, likely due to increased thickness at the disc-accretion stream interface preventing flares being visible during the pre-eclipse phase. This supports the notion that variable obscuration is responsible for the unusually strong variability in Swift J1858.6-0814., Comment: 12 pages, 11 figures, MNRAS accepted

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results