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34. IFPA Meeting 2012 Workshop Report III: Trophoblast deportation, gestational trophoblastic disease, placental insufficiency and fetal growth restriction, trophoblast over-invasion and accreta-related pathologies, placental thrombosis and fibrinolysis

Author

Al-Khan, A., Bulmer, J. N., Chantraine, F., Chen, C. P., Chen, Q., Collins, S., Cotechini, T., Fitzgerald, J. S., He, M., Holland, O., Hung, T. H., Illsley, N. P., Ino, K., Iwaki, T., Kanayama, N., Kaneki, E., Katabuchi, H., Kobayashi, Y., Kondo, A., Masuzaki, H., Matjila, M., Miura, K., Mori, A., Murthi, P., Nagahashi, K., Nie, G., Ohba, T., Sood, R., Sugimura, M., Takizawa, T., Usui, H., Velicky, P., Lash, G. E., Al-Khan, A., Bulmer, J. N., Chantraine, F., Chen, C. P., Chen, Q., Collins, S., Cotechini, T., Fitzgerald, J. S., He, M., Holland, O., Hung, T. H., Illsley, N. P., Ino, K., Iwaki, T., Kanayama, N., Kaneki, E., Katabuchi, H., Kobayashi, Y., Kondo, A., Masuzaki, H., Matjila, M., Miura, K., Mori, A., Murthi, P., Nagahashi, K., Nie, G., Ohba, T., Sood, R., Sugimura, M., Takizawa, T., Usui, H., Velicky, P., and Lash, G. E.

Abstract

Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialized topics. At IFPA meeting 2012 there were twelve themed workshops, five of which are summarized in this report. These workshops related to various aspects of placental biology but collectively covered areas of clinical research and pregnancy disorders: 1) trophoblast deportation; 2) gestational trophoblastic disease; 3) placental insufficiency and fetal growth restriction; 4) trophoblast overinvasion and accreta-related pathologies; 5) placental thrombosis and fibrinolysis.

Published
2013

35. IFPA Meeting 2011 workshop report III : Placental immunology; Epigenetic and microRNA-dependent gene regulation; Comparative placentation; Trophoblast differentiation; Stem cells

Author

Ackerman IV, W. E., Bulmer, J. N., Carter, A. M., Chaillet, J. R., Chamley, L., Chen, C. P., Chuong, E. B., Coleman, S. J., Collet, G. P., Croy, B. A., De Mestre, A. M., Dickinson, H., Ducray, J., Enders, A. C., Fogarty, N. M.E., Gauster, M., Golos, T., Haider, S., Heazell, A. E., Holland, O. J., Huppertz, B., Husebekk, A., John, R. M., Johnsen, G. M., Jones, C. J.P., Kalionis, B., König, J., Lorenzon, A. R., Moffett, A., Moreira De Mello, J. C., Nuzzo, A. M., Parham, P., Parolini, O., Petroff, M. G., Pidoux, G., Ramírez-Pinilla, M. P., Robinson, W. P., Rolfo, A., Sadovsky, Y., Soma, H., Southcombe, J. H., Tilburgs, T., Lash, G. E., Ackerman IV, W. E., Bulmer, J. N., Carter, A. M., Chaillet, J. R., Chamley, L., Chen, C. P., Chuong, E. B., Coleman, S. J., Collet, G. P., Croy, B. A., De Mestre, A. M., Dickinson, H., Ducray, J., Enders, A. C., Fogarty, N. M.E., Gauster, M., Golos, T., Haider, S., Heazell, A. E., Holland, O. J., Huppertz, B., Husebekk, A., John, R. M., Johnsen, G. M., Jones, C. J.P., Kalionis, B., König, J., Lorenzon, A. R., Moffett, A., Moreira De Mello, J. C., Nuzzo, A. M., Parham, P., Parolini, O., Petroff, M. G., Pidoux, G., Ramírez-Pinilla, M. P., Robinson, W. P., Rolfo, A., Sadovsky, Y., Soma, H., Southcombe, J. H., Tilburgs, T., and Lash, G. E.

Abstract

Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialised topics. At IFPA meeting 2011 there were twelve themed workshops, five of which are summarized in this report. These workshops related to various aspects of placental biology: 1) immunology; 2) epigenetics; 3) comparative placentation; 4) trophoblast differentiation; 5) stem cells.

Published
2012

36. IFPA Meeting 2011 workshop report III: Placental immunology; epigenetic and microRNA-dependent gene regulation; comparative placentation; trophoblast differentiation; stem cells

Author

Ackerman, W. E, Bulmer, J. N, Carter, A. M, Chaillet, J. R, Chamley, L, Chen, C. P, Chuong, E. B, Coleman, S. J, Collet, G. P, Croy, B. A, de Mestre, A. M, Dickinson, H, Ducray, J, Enders, A. C, Fogarty, N. M. E, Gauster, M, Golos, T, Haider, S, Heazell, A. E, Holland, O. J, Huppertz, B, Husebekk, A, John, R. M, Johnsen, G. M, Jones, C. J. P, Kalionis, B, König, J, Lorenzon, A. R, Moffett, A, Moreira de Mello, J. C, Nuzzo, A. M, Parham, P, Parolini, Ornella, Petroff, M. G, Pidoux, G, Ramírez Pinilla, M. P, Robinson, W. P, Rolfo, A, Sadovsky, Y, Soma, H, Southcombe, J. H, Tilburgs, T, Lash, G. E., Parolini, Ornella (ORCID:0000-0002-5211-6430), Ackerman, W. E, Bulmer, J. N, Carter, A. M, Chaillet, J. R, Chamley, L, Chen, C. P, Chuong, E. B, Coleman, S. J, Collet, G. P, Croy, B. A, de Mestre, A. M, Dickinson, H, Ducray, J, Enders, A. C, Fogarty, N. M. E, Gauster, M, Golos, T, Haider, S, Heazell, A. E, Holland, O. J, Huppertz, B, Husebekk, A, John, R. M, Johnsen, G. M, Jones, C. J. P, Kalionis, B, König, J, Lorenzon, A. R, Moffett, A, Moreira de Mello, J. C, Nuzzo, A. M, Parham, P, Parolini, Ornella, Petroff, M. G, Pidoux, G, Ramírez Pinilla, M. P, Robinson, W. P, Rolfo, A, Sadovsky, Y, Soma, H, Southcombe, J. H, Tilburgs, T, Lash, G. E., and Parolini, Ornella (ORCID:0000-0002-5211-6430)

Abstract

Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialised topics. At IFPA meeting 2011 there were twelve themed workshops, five of which are summarized in this report. These workshops related to various aspects of placental biology: 1) immunology; 2) epigenetics; 3) comparative placentation; 4) trophoblast differentiation; 5) stem cells.

Published
2012

37. Expression of thyroid hormone transporters in the human placenta and changes associated with intrauterine growth restriction

Author

Loubière, L S, Vasilopoulou, E, Bulmer, J N, Taylor, P M, Stieger, B, Verrey, F, McCabe, C J, Franklyn, J A, Kilby, M D, Chan, S-Y, Loubière, L S, Vasilopoulou, E, Bulmer, J N, Taylor, P M, Stieger, B, Verrey, F, McCabe, C J, Franklyn, J A, Kilby, M D, and Chan, S-Y

Abstract

Thyroid hormones (TH) are important for the development of the human fetus and placenta from very early gestation. The transplacental passage of TH from mother to fetus and the supply of TH into trophoblasts require the expression of placental TH plasma membrane transporters. We describe the ontogeny of the TH transporters MCT8, MCT10, LAT1, LAT2, OATP1A2 and OATP4A1 in a large series (n = 110) of normal human placentae across gestation and describe their expression changes with intrauterine fetal growth restriction (IUGR n = 22). Quantitative RT-PCR revealed that all the mRNAs encoding TH transporters are expressed in human placenta from 6 weeks gestation and throughout pregnancy. MCT8, MCT10, OATP1A2 and LAT1 mRNA expression increased with gestation. OATP4A1 and CD98 (LATs obligatory associated protein) mRNA expression reached a nadir in mid-gestation before increasing towards term. LAT2 mRNA expression did not alter throughout gestation. Immunohistochemistry localised MCT10 and OATP1A2 to villous cytotrophoblasts and syncytiotrophoblasts, and extravillous trophoblasts while OATP4A1 was preferentially expressed in the villous syncytiotrophoblasts. Whilst MCT8 protein expression was increased, MCT10 mRNA expression was decreased in placentae from IUGR pregnancies delivered in the early 3rd trimester compared to age matched appropriately grown for gestational age controls. No significant change was found in the mRNA expression of the other transporters with IUGR. In conclusion, several TH transporters are present in the human placenta from early 1st trimester with varying patterns of expression throughout gestation. Their coordinated effects may regulate both transplacental TH passage and TH supply to trophoblasts, which are critical for the normal development of the fetus and placenta. Increased MCT8 and decreased MCT10 expression within placentae of pregnancies complicated by IUGR may contribute to aberrant development of the fetoplacental unit.

Published
2010

39. Endometriosis, endometrium, implantation and fallopian tube

Author

Tan, C. W., primary, Lee, Y. H., additional, Choolani, M., additional, Tan, H. H., additional, Griffith, L., additional, Chan, J., additional, Chuang, P. C., additional, Wu, M. H., additional, Lin, Y. J., additional, Tsai, S. J., additional, Rahmati, M., additional, Petitbarat, M., additional, Dubanchet, S., additional, Bensussan, A., additional, Chaouat, G., additional, Ledee, N., additional, Bissonnette, L., additional, Haouzi, D., additional, Monzo, C., additional, Traver, S., additional, Bringer, S., additional, Faidherbe, J., additional, Perrochia, H., additional, Ait-Ahmed, O., additional, Dechaud, H., additional, Hamamah, S., additional, Ibrahim, M. G., additional, de Arellano, M. L. B., additional, Sachtleben, M., additional, Chiantera, V., additional, Frangini, S., additional, Younes, S., additional, Schneider, A., additional, Plendl, J., additional, Mechsner, S., additional, Ono, M., additional, Hamai, H., additional, Chikawa, A., additional, Teramura, S., additional, Takata, R., additional, Sugimoto, T., additional, Iwahashi, K., additional, Ohhama, N., additional, Nakahira, R., additional, Shigeta, M., additional, Park, I. H., additional, Lee, K. H., additional, Sun, H. G., additional, Kim, S. G., additional, Lee, J. H., additional, Kim, Y. Y., additional, Kim, H. J., additional, Jeon, G. H., additional, Kim, C. M., additional, Bocca, S., additional, Wang, H., additional, Anderson, S., additional, Yu, L., additional, Horcajadas, J., additional, Oehninger, S., additional, Bastu, E., additional, Mutlu, M. F., additional, Celik, C., additional, Yasa, C., additional, Dural, O., additional, Buyru, F., additional, Quintana, F., additional, Cobo, A., additional, Remohi, J., additional, Ferrando, M., additional, Matorras, R., additional, Bermejo, A., additional, Iglesias, C., additional, Cerrillo, M., additional, Ruiz, M., additional, Blesa, D., additional, Simon, C., additional, Garcia-Velasco, J. A., additional, Chamie, L., additional, Ribeiro, D. M. F., additional, Riboldi, M., additional, Pereira, R., additional, Rosa, M. B., additional, Gomes, C., additional, de Mello, P. H., additional, Fettback, P., additional, Domingues, T., additional, Cambiaghi, A., additional, Soares, A. C. P., additional, Kimati, C., additional, Motta, E. L. A., additional, Serafini, P., additional, Hapangama, D. K., additional, Valentijn, A. J., additional, Al-Lamee, H., additional, Palial, K., additional, Drury, J. A., additional, von Zglinicki, T., additional, Saretzki, G., additional, Gargett, C. E., additional, Liao, C. Y., additional, Sung, Y. J., additional, Li, H. Y., additional, Morotti, M., additional, Remorgida, V., additional, Venturini, P. L., additional, Ferrero, S., additional, Nabeta, M., additional, Iki, A., additional, Hashimoto, H., additional, Koizumi, M., additional, Matsubara, Y., additional, Hamada, K., additional, Fujioka, T., additional, Matsubara, K., additional, Kusanagi, Y., additional, Nawa, A., additional, Zanatta, A., additional, da Rocha, A. M., additional, Guerra, J. L., additional, Cogliati, B., additional, Bianchi, P. d. M., additional, Prieto, B., additional, Exposito, A., additional, Mendoza, R., additional, Rabanal, A., additional, Bedaiwy, M., additional, Yi, L., additional, Dahoud, W., additional, Liu, J., additional, Hurd, W., additional, Falcone, T., additional, Biscotti, C., additional, Mesiano, S., additional, Sugiyama, R., additional, Nakagawa, K., additional, Nishi, Y., additional, Kuribayashi, Y., additional, Akira, S., additional, Germeyer, A., additional, Rosner, S., additional, Jauckus, J., additional, Strowitzki, T., additional, von Wolff, M., additional, Khan, K. N., additional, Kitajima, M., additional, Fujishita, A., additional, Nakashima, M., additional, Masuzaki, H., additional, Kajihara, T., additional, Ishihara, O., additional, Brosens, J., additional, Vezmar, K., additional, Savournin, V., additional, Balet, R., additional, Loh, S. F., additional, Tannenbaum, S. R., additional, Chan, J. K. Y., additional, Scarella, A., additional, Chamy, V., additional, Devoto, L., additional, Abrao, M., additional, Sovino, H., additional, Krasnopolskaya, K., additional, Popov, A., additional, Kabanova, D., additional, Beketova, A., additional, Ivakhnenko, V., additional, Shohayeb, A., additional, Wahba, A., additional, Abousetta, A., additional, al-inany, H., additional, El Daly, A., additional, Zayed, M., additional, Kvaskoff, M., additional, Han, J., additional, Missmer, S. A., additional, Navarro, P., additional, Meola, J., additional, Ribas, C. P., additional, Paz, C. P., additional, Ferriani, R. A., additional, Donabela, F. C., additional, Tafi, E., additional, Maggiore, U. L. R., additional, Scala, C., additional, Hackl, J., additional, Strehl, J., additional, Wachter, D., additional, Dittrich, R., additional, Cupisti, S., additional, Hildebrandt, T., additional, Lotz, L., additional, Attig, M., additional, Hoffmann, I., additional, Renner, S., additional, Hartmann, A., additional, Beckmann, M. W., additional, Urquiza, F., additional, Ferrer, C., additional, Incera, E., additional, Azpiroz, A., additional, Junovich, G., additional, Pappalardo, C., additional, Guerrero, G., additional, Pasqualini, S., additional, Gutierrez, G., additional, Corti, L., additional, Sanchez, A. M., additional, Bordignon, P. P., additional, Santambrogio, P., additional, Levi, S., additional, Persico, P., additional, Vigano, P., additional, Papaleo, E., additional, Ferrari, S., additional, Candiani, M., additional, van der Houwen, L. E. E., additional, Schreurs, A. M. F., additional, Lambalk, C. B., additional, Schats, R., additional, Hompes, P. G. A., additional, Mijatovic, V., additional, Xu, S. Y., additional, Li, J., additional, Chen, X. Y., additional, Chen, S. Q., additional, Guo, L. Y., additional, Mathew, D., additional, Nunes, Q., additional, Lane, B., additional, Fernig, D., additional, Hapangama, D., additional, Lind, T., additional, Hammarstrom, M., additional, Golmann, D., additional, Rodriguez-Wallberg, K., additional, Hestiantoro, A., additional, Cakra, A., additional, Aulia, A., additional, Al-Inany, H., additional, Houston, B., additional, Farquhar, C., additional, Tagliaferri, V., additional, Gagliano, D., additional, Immediata, V., additional, Tartaglia, C., additional, Zumpano, A., additional, Campagna, G., additional, Lanzone, A., additional, Guido, M., additional, Matsuzaki, S., additional, Darcha, C., additional, Botchorishvili, R., additional, Pouly, J. L., additional, Mage, G., additional, Canis, M., additional, Shivhare, S. B., additional, Bulmer, J. N., additional, Innes, B. A., additional, Lash, G. E., additional, de Graaff, A. A., additional, Zandstra, H., additional, Smits, L. J., additional, Van Beek, J. J., additional, Dunselman, G. A. J., additional, Bozdag, G., additional, Calis, P. T., additional, Demiralp, D. O., additional, Ayhan, B., additional, Igci, N., additional, Yarali, H., additional, Acar, N., additional, Er, H., additional, Ozmen, A., additional, Ustunel, I., additional, Korgun, E. T., additional, Kuroda, K., additional, Kuroda, M., additional, Arakawa, A., additional, Kitade, M., additional, Brosens, A. I., additional, Brosens, J. J., additional, Takeda, S., additional, and Yao, T., additional

Published
2013
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40. Lectin histochemistry of pregnant rat uterine tissues

Author

Peel, S and Bulmer, J N

Subjects
animal structures, Histocytochemistry, Uterus, Metrial Gland, Rats, Pregnancy, Lectins, embryonic structures, Decidua, Animals, Pregnancy, Animal, Female, Rats, Wistar, Glycoconjugates, Research Article
Abstract

Glycoconjugate residues were examined in the rat uterus at days 10, 12 and 15 of pregnancy using 17 biotinylated lectins with specificities for a variety of carbohydrate moieties. A wide variety of glycoconjugate residues were detected in the cytoplasm of some antimesometrial and mesometrial decidual cells with lectins from Canavalia ensiformis (Con A), Lens culinaris (LcH) culinaris (LcH), Pisum sativum (PSA), Griffonia simplicifolia II (GS-II), Triticum vulgaris (WGA), Griffonia simplicifolia I (GS-I), Maclura pomifera (MPA) and Phaseolus vulgaris (PHA-E and PHA-L). Reactivity with some of these lectins was also pericellular and the glycoconjugate residues detected may be related to extracelluar matrix produced by decidual cells. Reactivity with PHA-E, demonstrating complex carbohydrates, was most intense in the mesometrial decidua closest to the trophoblastic giant cells and may demonstrate glycoconjugates involved in maintaining integrity at this maternotrophoblast interface. Lectins derived from Helix pomatia (HPA), Vicia villosa (VVA), Glycine max (SBA) and Arachis hypogaea (PNA) reacted only with occasional small cells in antimesometrial or mesometrial decidua, probably demonstrating alpha and/ or beta-linked N-acetylgalactosamine residues on lymphocytes or monocytes. The glycoprotein granules of granulated metrial gland (GMG) cells in the decidua basalis and the metrial gland reacted strongly with WGA, MPA and PHA-L demonstrating complex carbohydrates including sialic acid residues and tri/tetra-antennary, nonbisected N-linked glycans. GMG cell cytoplasm reacted diffusely with Con A, LcH, PSA, WGA, PHA-E and PHA-L. In some GMG cells reactivity with WGA was apparently localised to the Golgi region indicating involvement in granule formation. Pericellular reactivity of some GMG cells with WGA may relate to migratory activity. The lectin reactivity of fibroblast-like stromal cells in the material gland was similar to that of the extracellular matrix and it is likely that many matrix molecules are produced by the stromal cells. A range of lectins (Con A, LcH, PSA, GS-II GS-I and PHA-L) reacted with some blood vessels in the metrial gland at day 12 of pregnancy: this may indicate activation changes associated with the transendothelial passage of GMG cells at this stage. Lectins derived from Dolichos biflorus (DBA), Bauhinia purpurea (BPA), Lotus tetragonolobus (LTA) and Ulex europaeus-I (UEA-I) did not react with decidual and metrial gland regions. Lectin binding profile studies can provide further information on the events occurring in the uterus in pregnancy: investigations at the ultrastructural level are required to resolve further intra and extracellular changes.

Published
1996

41. SESSION 05: EARLY PREGNANCY

Author

Mignini Renzini, M., primary, Dal Canto, M., additional, Coticchio, G., additional, Novara, P., additional, Turchi, D., additional, Lain, M., additional, Guarnieri, T., additional, Brambillasca, F., additional, Fadini, R., additional, Lash, G. E., additional, Innes, B. A., additional, Drury, J. A., additional, Quenby, S., additional, Bulmer, J. N., additional, Goddijn, M., additional, Boogaard van den, E., additional, Scheenjes, E., additional, Kremer, J. A. M., additional, Veen van der, F., additional, Hermens, R. P. M. G., additional, Vansenne, F., additional, De Borgie, C. A. J. M., additional, Snijder, S., additional, Redeker, E. J. W., additional, Van Maarle, M. C., additional, Wouters, C. H., additional, Bruggenwirth, H. T., additional, Van der Veen, F., additional, Bossuyt, P. M. M., additional, Ledger, W., additional, Alsbjerg, B., additional, Tomas, C., additional, Martikainen, H., additional, and Humaidan, P., additional

Published
2012
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