Search

Your search keyword '"Bulkow, Lisa R."' showing total 275 results
Start Over Author "Bulkow, Lisa R."
275 results on '"Bulkow, Lisa R."'

1. The relative invasive disease potential of Streptococcus pneumoniae among children after PCV introduction: A systematic review and meta-analysis

Author

Balsells, Evelyn, Dagan, Ron, Yildirim, Inci, Gounder, Prabhu P., Steens, Anneke, Muñoz-Almagro, Carmen, Mameli, Chiara, Kandasamy, Rama, Givon Lavi, Noga, Daprai, Laura, van der Ende, Arie, Trzciński, Krzysztof, Nzenze, Susan A., Meiring, Susan, Foster, Dona, Bulkow, Lisa R., Rudolph, Karen, Valero-Rello, Ana, Ducker, Struan, Vestrheim, Didrik Frimann, von Gottberg, Anne, Pelton, Stephen I., Zuccotti, GianVincenzo, Pollard, Andrew J., Sanders, Elisabeth A.M., Campbell, Harry, Madhi, Shabir A., Nair, Harish, and Kyaw, Moe H.

Published
2018
Full Text
View/download PDF

14. Invasive pneumococcal disease caused by nonvaccine serotypes among Alaska native children with high levels of 7-valent pneumococcal conjugate vaccine coverage

Author

Singleton, Rosalyn J., Hennessey, Thomas W., Bulkow, Lisa R, Hammitt, Laura L., Zulz, Tammy, Hurlburt, Debby A., Butler, Jay C., Rudolph, Karen, and Parkinson, Alan

Subjects
Pneumococcal infections -- Care and treatment, Conjugate vaccines -- Research, Conjugate vaccines -- Usage, Children -- Diseases, Children -- Care and treatment
Abstract

The association between the replacement disease and the overall decline in invasive pneumococcal disease among Alaska Native children is investigated. The results have shown that Alaska Native children are experiencing replacement invasive pneumococcal disease with serotypes not covered by heptavalent pneumococcal conjugate vaccine.

Published
2007

18. Risk factors for severe respiratory syncytial virus infection among Alaska Native children

Author

Bulkow, Lisa R., Singleton, Rosalyn J., Karron, Ruth A., and Harrison, Lee H.

Subjects
Respiratory syncytial virus infection -- Risk factors, Native Americans -- Alaska
Abstract

Objective. The incidence of hospitalization for respiratory syncytial virus (RSV) infection among Alaska Native children is much higher than among non-Native populations in the United States. We conducted this study to better understand factors associated with hospitalization attributable to RSV infection in this high-risk population. Design. Case-control study, including collection of cord blood for RSV-neutralizing antibody measurement. Setting. Remote region of southwest Alaska served by 1 regional hospital and 2 referral hospitals. Subjects. Case-patients identified through surveillance for RSV infection and matched control subjects without acute respiratory infection hospitalization. Results. Breastfeeding was associated with a lower risk of RSV hospitalization (odds ratio: 0.34), whereas underlying medical conditions (primarily prematurity) were associated with increased risk (odds ratio: 6.25). Environmental factors associated with a higher risk of hospitalization included household crowding (4 or more children in the household and crowding index [greater than or equal to] 2). The level of maternal RSV-neutralizing antibody was not associated with the risk of hospitalization. Conclusions. In this region with extremely high risk of RSV hospitalization, several measures, such as encouraging breastfeeding and reducing household crowding, could reduce the risk of hospitalization attributable to RSV. Pediatrics 2002;109:210-216; respiratory syncytial virus, Alaska Natives, breastfeeding., ABBREVIATIONS. RSV, respiratory syncytial virus; ARI, acute respiratory infection; YK, Yukon Kuskokwim; YKDRH, YK Delta Regional Hospital; JHU, Johns Hopkins University; OR, odds ratio; BPD, bronchopulmonary dysplasia; LRI, lower respiratory [...]

Published
2002

22. Transplacental Respiratory Syncytial Virus and Influenza Virus Antibody Transfer in Alaska Native and Seattle Mother–Infant Pairs

Author

Chu, Helen Y, primary, Newman, Kira L, additional, Englund, Janet A, additional, Cho, Shari, additional, Bull, Catherine, additional, Lacombe, Kirsten, additional, Carlin, Kristen, additional, Bulkow, Lisa R, additional, Rudolph, Karen, additional, DeByle, Carolynn, additional, Berner, James, additional, Klejka, Joseph, additional, and Singleton, Rosalyn, additional

Published
2020
Full Text
View/download PDF

29. Dietary change and obesity associated with glucose intolerance in Alaska natives

Author

Murphy, Neil J., Schraer, Cynthia D., Thiele, Maureen C., Boyko, Edward J., Bulkow, Lisa R., Doty, Barbara J., and Lanier, Anne P.

Subjects
Obesity -- Causes of -- Research, Dextrose -- Research -- Health aspects, Glucose -- Research -- Health aspects, Inuit -- Health aspects -- Research, Food/cooking/nutrition, Research, Causes of, Health aspects
Abstract

The precontact (ie, before contact with Western civilization) Alaska Native diet was primarily limited to protein from fish, moose, caribou, and marine mammals (1). Carbohydrate content increased from 3% to [...]

Published
1995

30. Pneumococcal vaccination in a remote population of high-risk Alaska natives

Author

Davidson, Michael, Chamblee, Carol, Campbell, Henry G., Bulkow, Lisa R., Taylor, Grady E., Lanier, Anne P., Berner, James, Spika, John S., Williams, Walter W., and Middaugh, John P.

Subjects
Streptococcus pneumoniae -- Prevention, Pneumococcal vaccine -- Usage, Inuit -- Alaska
Abstract

Among the 10 most common causes of hospitalization and death, pneumonia and influenza are the only disorders for which efficacious vaccines are available. Besides causing both lobar and bronchopneumonia, Streptococcus […]

Published
1993

36. Transplacental Respiratory Syncytial Virus and Influenza Virus Antibody Transfer in Alaska Native and Seattle Mother–Infant Pairs.

Author

Chu, Helen Y, Newman, Kira L, Englund, Janet A, Cho, Shari, Bull, Catherine, Lacombe, Kirsten, Carlin, Kristen, Bulkow, Lisa R, Rudolph, Karen, DeByle, Carolynn, Berner, James, Klejka, Joseph, and Singleton, Rosalyn

Subjects
INFLUENZA prevention, INFLUENZA vaccines, HEMAGGLUTINATION tests, IMMUNIZATION, MATERNAL-fetal exchange, RURAL conditions, MOTHER-infant relationship, POPULATION geography, COMPARATIVE studies, CORD blood, RESPIRATORY syncytial virus infections, VIRAL antibodies, PREGNANCY, FETUS
Abstract

Background Alaska Native (AN) infants are at risk for severe disease due to respiratory syncytial virus (RSV) and influenza. Maternal immunization protects young infants through transplacental antibody transfer. RSV- and influenza-specific transplacental antibody transfer in mother–infant pairs has not previously been evaluated in the AN population. Methods Serum samples collected during pregnancy and at birth from AN mother–infant pairs in the Yukon-Kuskokwim Delta region (YKD) of Alaska (2000–2011; n = 75) and predominantly white pairs in Seattle, Washington (2014–2016; n = 57), were tested for RSV and influenza antibody using a microneutralization and hemagglutination inhibition assay, respectively, and compared between sites. Results Mean RSV antibody concentrations in pregnant women in YKD and Seattle were similar (log2 RSV antibody 10.6 vs 10.7, P =.86), but cord blood RSV antibody concentrations were significantly lower in infants born to mothers in YKD compared with Seattle (log2 RSV antibody 11.0 vs 12.2, P <.001). Maternal and cord blood influenza antibody concentrations were lower for women and infants in YKD compared with Seattle for all 4 influenza antigens tested (all P <.05). The mean cord to maternal RSV antibody transfer ratio was 1.15 (standard deviation [SD], 0.13) in mother–infant pairs in Seattle compared with 1.04 (SD, 0.08) in YKD. Mean cord blood to maternal antibody transfer ratios for influenza antigens ranged from 1.22 to 1.42 in Seattle and from 1.05 to 1.59 in YKD. Conclusions Though the transplacental antibody transfer ratio was high (>1.0) for both groups, transfer ratios for RSV antibody were significantly lower in AN mother–infant pairs. Further studies are needed to elucidate the impact of lower transplacental antibody transfer on infant disease risk in rural Alaska. Alaska Native and continental US mother-infant pairs have high transplacental antibody transfer ratios (>1.0) for influenza and respiratory syncytial virus, but anti-respiratory syncytial virus antibody levels are significantly lower in Alaska Native pairs than in those from the continental US. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

37. Immunogenicity of pneumococcal revaccination in patients with chronic disease

Author

Davidson, Michael, Bulkow, Lisa R., Grabman, James, Parkinson, Alan J., Chamblee, Carol, Williams, Walter W., Lanier, Anne P., and Schiffman, Gerald

Subjects
Pneumococcal vaccine -- Evaluation, Vaccination -- Physiological aspects, Chronic diseases -- Physiological aspects, Health
Abstract

Background: To prevent serious pneumococcal infections, 23-valent pneumococcal polysaccharide vaccine is recommended for individuals over 24 months of age with chronic predisposing diseases and for healthy older adults. This nonrandomized controlled study in rural Alaska assessed the immunogenicity of revaccination in adults. Methods: Twenty-six adults, 33 to 88 years of age, vaccinated a mean of 7.4 years before this study, were matched to 26 previously unvaccinated subjects by age, number of chronic diseases, sex, and ethnicity. One or more chronic diseases were validated in 62% of subjects (32 of 52). All received a first or second intramuscular dose of pneumococcal vaccine. Antibody levels were determined by radioimmunoassay for 12 pneumococcal capsular serotypes immediately before and 20 to 84 days after vaccination. Results: Six to 9 years after primary vaccination, over one third of serotype-specific antibody levels were below 500 ng of antibody nitrogen per milliliter, equal to the percentage in unvaccinated subjects of similar age. Antibody levels against all pneumococcal serotypes rose to similar levels after primary vaccination and revaccination, and 54% and 55%, respectively, of subjects who received primary vaccination and revaccination had at least a 1.4-fold increase in antibody levels. Only the antibody level for serotype 4 remained low. Neither gender nor age affected peak response. For those with chronic diseases, there was a trend toward fewer low antibody levels against three or more serotypes after revaccination (two subjects [13%]) than after primary vaccination (five subjects [31%]). Conclusions: Following the initial immunization of high-risk and elderly patients with pneumococcal polysaccharide, pneumococcal antibody levels appear to wane with time. Primary vaccination and revaccination 6 or more years after a first dose of pneumococcal vaccine stimulate comparable mean antibody levels. (Arch Intern Med. 1994;154:2209-2214)

Published
1994

38. Elevated concentrations of plasma omega-3 polyunsaturated fatty acids among Alaskan Eskimos

Author

Parkinson, Alan J., Cruz, Aurea L., Heyward, William L., Bulkow, Lisa R., Hall, David, Barstaed, Louise, and Connor, William E.

Subjects
Inuit -- Food and nutrition, Omega-3 fatty acids -- Health aspects, Blood platelets -- Aggregation, Food/cooking/nutrition, Health
Abstract

Eskimos living in rural southwestern Alaska depend on fish and marine mammals as major sources of subsistence food. Fatty acid concentrations in 80 Yupik Eskimos living in either a coastal or river village of southwestern Alaska were compared with those of non-Native control subjects. Concentrations of total plasma [omega]-3 fatty acids, eicosapentaenoic acid (20:5[omega]-3), and docosahexaenoic acid (22:6[omega])-3) were 4.3, 13, and 6.8 times higher, respectively, in Native participants than in non-Native control subjects. Concentrations of these fatty acids were higher in coastal-village than in river-village participants; concentrations paralleled consumption of marine mammal oil and marine fish. The ratios of eicosapentaenoic to arachidonic acid for adult coastal- and river-village participants were 1.16 and 0.70, respectively, 14 and 9 times those of non-Native adults, respectively. There was no increase in the mean bleeding times of Native participants of either village.

Published
1994

39. Prevalence ofHelicobacter pyloriamong Alaskans: Factors associated with infection and comparison of urea breath test and anti-Helicobacter pyloriIgG antibodies

Author

Miernyk, Karen M., primary, Bulkow, Lisa R., additional, Gold, Benjamin D., additional, Bruce, Michael G., additional, Hurlburt, Debby H., additional, Griffin, Patricia M., additional, Swerdlow, David L., additional, Cook, Kim, additional, Hennessy, Thomas W., additional, and Parkinson, Alan J., additional

Published
2018
Full Text
View/download PDF

40. The relative invasive disease potential of Streptococcus pneumoniae among children after PCV introduction: A systematic review and meta-analysis

Author

Immuno/reuma onderzoek 8 (Trzcinski), Child Health, Infection & Immunity, Immuno/reuma onderzoek 7 (Montfrans), Immuno/reuma patientenzorg, Balsells, Evelyn, Dagan, Ron, Yildirim, Inci, Gounder, Prabhu P., Steens, Anneke, Muñoz-Almagro, Carmen, Mameli, Chiara, Kandasamy, Rama, Givon Lavi, Noga, Daprai, Laura, van der Ende, Arie, Trzciński, Krzysztof, Nzenze, Susan A., Meiring, Susan, Foster, Dona, Bulkow, Lisa R., Rudolph, Karen, Valero-Rello, Ana, Ducker, Struan, Vestrheim, Didrik Frimann, von Gottberg, Anne, Pelton, Stephen I., Zuccotti, Gian Vincenzo, Pollard, Andrew J., Sanders, Elisabeth A.M., Campbell, Harry, Madhi, Shabir A., Nair, Harish, Kyaw, Moe H., Immuno/reuma onderzoek 8 (Trzcinski), Child Health, Infection & Immunity, Immuno/reuma onderzoek 7 (Montfrans), Immuno/reuma patientenzorg, Balsells, Evelyn, Dagan, Ron, Yildirim, Inci, Gounder, Prabhu P., Steens, Anneke, Muñoz-Almagro, Carmen, Mameli, Chiara, Kandasamy, Rama, Givon Lavi, Noga, Daprai, Laura, van der Ende, Arie, Trzciński, Krzysztof, Nzenze, Susan A., Meiring, Susan, Foster, Dona, Bulkow, Lisa R., Rudolph, Karen, Valero-Rello, Ana, Ducker, Struan, Vestrheim, Didrik Frimann, von Gottberg, Anne, Pelton, Stephen I., Zuccotti, Gian Vincenzo, Pollard, Andrew J., Sanders, Elisabeth A.M., Campbell, Harry, Madhi, Shabir A., Nair, Harish, and Kyaw, Moe H.

Published
2018

46. Protection provided by hepatitis B vaccine in a Yupik Eskimo population

Author

Wainwright, Robert B., McMahon, Brian J., Bulkow, Lisa R., Parkinson, Alan J., and Harpster, Annette P.

Subjects
Hepatitis B vaccine -- Evaluation, Hepatitis B vaccine -- Physiological aspects, Yupiks -- Health aspects, Hepatitis B -- Prevention, Health
Abstract

Hepatitis B is an inflammatory condition affecting the liver that is caused by hepatitis B virus (HBV), which is transmitted mainly by blood and blood products. Protection against this chronic, sometimes fatal disease can often be afforded by immunization with a vaccine specific for HBV. To determine the efficacy and duration of protection that HBV immunization might confer on a large group of Yupik Eskimos (an Eskimo population with a high endemic HBV infection rate), a study was carried out in which 1,581 susceptible persons were immunized with the manufacturer-recommended three-dose regimen. Blood levels of HBV antibodies (molecules produced by the immune system to combat potential HBV infection) were measured annually for seven years. Antibody levels dropped off moderately for the first two years after immunization and were fairly constant for the remaining five years. An arbitrary standard was suggested as a first approximation of adequate HBV antibody levels for the purpose of indicating protection from HBV infection (10 milli-International Units per milliliter of blood); between 52 and 87 percent of the immunized subjects maintained these levels for the seven-year period, depending on age (older subjects showed a more rapid decline than younger). During the seven years following the first dose of vaccine, five responders (subjects who showed an increase in HBV antibody level) and three other persons showed blood changes suggestive of infection with HBV. No subjects developed overt symptoms of HBV, or showed evidence of HBV in the blood when tested by direct measurement. Hence, HBV immunization confers significant protection against infection by HBV. These results suggest that boosting the initial inoculation is not necessary for at least seven years. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1991

49. Prevalence of Helicobacter pylori among Alaskans: Factors associated with infection and comparison of urea breath test and anti‐Helicobacter pylori IgG antibodies.

Author

Miernyk, Karen M., Bulkow, Lisa R., Gold, Benjamin D., Bruce, Michael G., Hurlburt, Debby H., Griffin, Patricia M., Swerdlow, David L., Cook, Kim, Hennessy, Thomas W., and Parkinson, Alan J.

Subjects
*HELICOBACTER pylori infections, *PUBLIC health, *HELICOBACTER pylori, *DISEASE prevalence
Abstract

Abstract: Background: Helicobacter pylori is one of the most common human infections in the world, and studies in Alaska Native people, as well as other Indigenous peoples, have shown a high prevalence of this gastric infection. This study was undertaken to determine the prevalence of H. pylori infection by urea breath test (UBT) and anti‐ H. pylori IgG among Alaskans living in four regions of the state and to identify factors associated with infection. Methods: A convenience sample of persons > 6 months old living in five rural and one urban Alaskan community were recruited from 1996 to 1997. Participants were asked about factors possibly associated with infection. Sera were collected and tested for anti‐ H. pylori IgG antibodies; a UBT was administered to participants > 5 years old. Results: We recruited 710 people of whom 571 (80%) were Alaska Native and 467 (66%) were from rural communities. Rural residents were more likely to be Alaska Native compared with urban residents (P < .001). Of the 710 people, 699 (98%) had a serum sample analyzed, and 634 (97%) persons > 5 years old had a UBT performed. H. pylori prevalence was 69% by UBT and 68% by anti‐ H. pylori IgG. Among those with a result for both tests, there was 94% concordance. Factors associated with H. pylori positivity were Alaska Native racial status, age ≥ 20 years, rural region of residence, living in a crowded home, and drinking water that was not piped or delivered. Conclusions: Helicobacter pylori prevalence is high in Alaska, especially in Alaska Native persons and rural residents. Concordance between UBT and serology was also high in this group. Two socioeconomic factors, crowding and drinking water that was not piped or delivered, were found to be associated with H. pylori positivity. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results