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6 results on '"Bulgarelli, Simona"'

3. Detection of Myocardial Iron Overload with Magnetic Resonance By Native T1 and T2* Mapping Using a Segmental Approach

Author

Pepe, Alessia, primary, Pistoia, Laura, additional, Martini, Nicola, additional, De Marchi, Daniele, additional, Barison, Andrea, additional, Maggio, Aurelio, additional, Giovangrossi, Piera, additional, Bulgarelli, Simona, additional, Pasin, F. Mehtap, additional, Sarli, Roberto, additional, Massa, Antonella, additional, Roccamo, Gaetano, additional, Caini, Mauro, additional, Positano, Vincenzo, additional, and Meloni, Antonella, additional

Published
2018
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4. PRV-1, erythroid colonies and platelet Mpl are unrelated to thrombosis in essential thrombocythaemia.

Author

Vannucchi, Alessandro M, Pancrazzi, Alessandro, Antonioli, Elisabetta, Guglielmelli, Paola, Balestri, Francesca, Biscardi, Monica, Bulgarelli, Simona, Longo, Giovanni, Graziano, Claudio, Gugliotta, Luigi, Bosi, Alberto, Vannucchi, Alessandro M, Pancrazzi, Alessandro, Antonioli, Elisabetta, Guglielmelli, Paola, Balestri, Francesca, Biscardi, Monica, Bulgarelli, Simona, Longo, Giovanni, Graziano, Claudio, Gugliotta, Luigi, and Bosi, Alberto

Abstract

Udgivelsesdato: 2004-Oct, Females with the monoclonal type of essential thrombocythaemia (ET), based on the X-chromosome inactivation pattern (XCIP), have previously been shown to present a higher incidence of thrombosis than polyclonal ones. We aimed to assess correlations between XCIP, thrombosis, and three epigenetic markers of ET, namely PRV-1 overexpression, endogenous erythroid colony (EEC) formation, and reduced platelet Mpl content. Fifty-three (60%) of 88 subjects studied had monoclonal myelopoiesis and presented a 32% incidence of major thrombosis compared with 6% of polyclonal subjects (P = 0.009). The frequency of abnormalities of PRV-1, EEC, or Mpl was similar in monoclonal and polyclonal subjects (respectively, 28%, 48%, 75%, and 37%, 27%, 63%), and none of them correlated with thrombosis. We conclude that the exploited epigenetic markers constitute independent phenotypic variations and are not clustered according to monoclonality of myelopoiesis in ET; none of them could serve as a surrogate marker of thrombotic risk in male subjects with ET.

Published
2004

6. PRV-1, erythroid colonies and platelet Mpl are unrelated to thrombosis in essential thrombocythaemia.

Author

Vannucch, Alessandro M., Grossi, Alberto, Pancrazzi, Alessandro, Antonioli, Elisabetta, Guglielmelli, Paola, Balestri, Francesca, Biscardi, Monica, Bulgarelli, Simona, Longo, Giovanni, Graziano, Claudio, Gugliotta, Luigi, and Bosi, Alberto

Subjects
THROMBOSIS, THROMBOCYTOPENIA, CARDIOVASCULAR diseases, BLOOD platelets, X chromosome, SEX chromosomes
Abstract

Females with the monoclonal type of essential thrombocythaemia (ET), based on the X-chromosome inactivation pattern (XCIP), have previously been shown to present a higher incidence of thrombosis than polyclonal ones. We aimed to assess correlations between XCIP, thrombosis, and three epigenetic markers of ET, namelyPRV-1overexpression, endogenous erythroid colony (EEC) formation, and reduced platelet Mpl content. Fifty-three (60%) of 88 subjects studied had monoclonal myelopoiesis and presented a 32% incidence of major thrombosis compared with 6% of polyclonal subjects (P = 0·009). The frequency of abnormalities ofPRV-1, EEC, or Mpl was similar in monoclonal and polyclonal subjects (respectively, 28%, 48%, 75%, and 37%, 27%, 63%), and none of them correlated with thrombosis. We conclude that the exploited epigenetic markers constitute independent phenotypic variations and are not clustered according to monoclonality of myelopoiesis in ET; none of them could serve as a surrogate marker of thrombotic risk in male subjects with ET. [ABSTRACT FROM AUTHOR]

Published
2004
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