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Background: The aim of the study was to assess the association of physical activity (PA) with the presence of diabetes related complications among Bangladeshi type 2 diabetic subjects., Methods: This cross-sectional study was conducted in the Out Patient Department (OPD) of BIRDEM, Bangladesh. A group of 977 subjects were randomly selected and followed up. Diabetes was diagnosed following the WHO study group criteria. The level of PA was categorized into inactive/low (<150 min/week) and moderate-to-vigorous (≥150 min/week). The WHO recommended Asian criteria was used to identify general obesity. Retinopathy was detected by fundal photography, CKD by serum creatinine and hypertension was diagnosed clinically. Univariate and multivariate analyses were used to assess the associations of PA with diabetes related complications., Results: Out of the 977 subjects investigated, 468 were male and 509 were female (mean ± SD of age, 56 ± 8 years). In the study subjects, 74% were either inactive or in low PA and of them 65.1% were overweight/obese. Analysis showed that inactive/low PA was associated with all the three diabetes related complications (p < 0.001)-hypertension, retinopathy, and nephropathy. Multivariate analysis showed that inactive/low level of PA was strongly associated with complications like retinopathy (p < 0.001) and hypertension (p = 0.01) in the female patients. It was also found to be highly associated with retinopathy (p < 0.001) among the male patients., Conclusion: A large number of urban Bangladeshi population are involved only in low PA or remain inactive themselves, which is leading to obesity and it seems to have a strong association with diabetes related complications in this population., (Copyright © 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.)

Dyslipidemia is a major risk factor for macro-vascular complications in patients with type 2 diabetes mellitus (T2DM). Present study explored pattern and predictors of dyslipidemia in Bangladeshi T2DM patients. The cross-sectional study is conducted among 366 consecutive eligible T2DM patients aged >30 years, BIRDEM diabetic hospital, during July-to-December 2010. Physical examination, diabetic profile, lipid profile and serum createnine was performed. Adjusted odds ratio and confidence limit were generated through binary logistic regression. Most frequent form (59.3%) of dyslipidemia is low HDL. Duration of T2DM is significantly correlated with TC (P<0.05), HDL (P<0.05) and LDL (P<0.05) in both male and female. Glycemic control in terms of HbA1c >7% appeared as predictor of dyslipidemia (P<0.01). Duration T2DM is associated with increased risk of having higher TC (P<0.05), LDL (P<0.05) and lower HDL (P<0.01) and does not seem to affect triglyceride (P>0.05). T2DM with comorbid hypertension seems to predict hyper tri-glyceridemia and lower HDL. Both TC-HDL ratio and LDL-HDL ratio appeared as good predictor of all four parameters of dyslipidemia (P<0.01). The characteristic features of diabetic dyslipidemia are low HDL, high triglyceride and LDL cholesterol level. Low HDL level is the most frequent type of abnormality. Poor glycemic control, prolonged duration, coexisting hypertension predicts dyslipidemia in T2DM., (Copyright © 2013 Diabetes India. Published by Elsevier Ltd. All rights reserved.)

Background: The aim of the present study was to estimate the incidence of diabetic retinopathy (DR) among type 2 diabetic (T2D) subjects in Bangladesh., Methods: A random sample of 977 patients with T2D was recruited retrospectively in 2008 from newly diagnosed T2D patients who had attended the Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorder (BIRDEM) in 1993. Baseline information for the cohort was collected for 1993 from hospital records. The mean time until development of DR in newly diagnosed T2D patients was calculated using survival analysis. Cox's proportional hazards model was used to assess factors affecting the time until development of DR., Results: The cumulative incidence of DR over the 15-year period was 50.6% (95% confidence interval [CI] 47.5%-53.8%). The incidence density (per 100 person-years) of DR was similar in the overall cohort (4.1; 95% CI 3.7-4.5) and in men (4.2; 95% CI 3.7-4.7) and women (4.1; 95% CI 3.6-4.6) separately. The mean time (in years) until development of DR in the cohort was 9.72 (95% CI 9.38-10.06), with similar times in men (9.8; 95% CI 9.3-10.3) and women (9.6; 95% CI 9.5-10.1) analyzed separately. Age, sex, hypertension, lipid profile, HbA1c, and serum creatinine were entered into the hazards model simultaneously. However, only age (hazard ratio [HR] 0.75; 95% CI 0.61-0.92) and HbA1c (HR 0.52; 95% CI 0.33-0.82) had a significant effect on the time until development of DR., Conclusions: Glucose deregulation is the most important factor in the development of DR., (© 2012 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.)

Aims: To determine the risk factors associated with diabetic retinopathy (DR) in Bangladeshi type 2 diabetic subjects., Methods: A cohort of 977 type-2 diabetic patients was recruited retrospectively based on hospital records in 2008, who were naïve type-2 diabetes during 1993. Data on diabetes and lipid profile with serum creatinine and biophysical measures were obtained at baseline, 5, 10 and 15 years. DR was diagnosed by retinal color photography. Generalized linear models were used to assess the associations of clinical, biochemical and anthropometric variables with retinopathy at three follow-up. Cumulative exposures were determined based on average exposure to individual attribute. IRR and 95% CI were generated through Poisson regression model, adjusting for age-at-diagnosis of diabetes, baseline BMI, end-line waist-to-hip ratio and present physical activity status., Results: DR patients had significantly poorer glycemic control at all three follow-ups. Age, residence, physical activity, serum creatinine and hypertension appeared as independent risk factors for DR in all three follow-up points. Poisson regression model identified glucose deregulation (IRR 1.8; CI 1.5-2.1), hypertension (IRR 1.5; CI 1.2-1.8) and raised serum creatinine (IRR 1.9; CI 1.5-2.3) as significant predictors for DR adjusted for possible confounders. Work related moderate-to-heavy physical activity (IRR 0.2; CI 0.1-0.3) appeared as protective., Conclusions: Along with poor glycemic control, hypertension, nephropathy are independent risk factor retinopathy., (Copyright © 2012. Published by Elsevier Ltd.)