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7. Characteristics and treatment regimens across ERS SHARP severe asthma registries

Author

van Bragt, JJMH, Adcock, IM, Bel, EHD, Braunstahl, G-J, ten Brinke, A, Busby, J, Canonica, GW, Cao, H, Chung, KF, Csoma, Z, Dahlen, B, Davin, E, Hansen, S, Heffler, E, Horvath, I, Korn, S, Kots, M, Kuna, P, Kwon, N, Louis, R, Plaza, V, Porsbjerg, C, Ramos-Barbon, D, Richards, LB, Skrgat, S, Sont, JK, Vijverberg, SJH, Weersink, EJM, Yasinska, V, Wagers, SS, Djukanovic, R, Maitland-van der Zee, AH, Abenhardt, B, Adler, J, Alfonso, R, Ali, R, Alkameh, S, Almonacid Sanchez, C, Alvares, L, Anderson, G, Assing, K, Ayre, S, Becker, J, Bergmann, K, Bieksiene, K, Bjerring, N, Blasi, F, Bloemen, P, Blum, H, Boeing, S, Bonavia, M, Bossios, A, Bourdin, A, Brons, A, Brusselle, G, Buis, J, Caiaffa, M, Calabrese, C, Camiciottoli, G, Caruso, C, Castilla Martinez, M, Centanni, S, Cisneros Serrano, C, Corsico, A, Cosmi, L, Costantino, M, Costello, R, Crimi, N, Dahlen, S, D'Amato, M, Davies, D, Garcia-Cosio Piqueras, FDB, Decarlo, G, Deimling, A, Del Giacco, S, Diaz Campos, R, Djandji, M, Doberer, D, Dupont, L, Dyett, K, Edelbaher, N, Edelmann, M, Ehmann, R, Ekberg-Jansson, A, Farsi, A, Favero, E, Feimer, J, Fletcher, M, Foschino, B, Frankemolle, B, Gaga, M, Gappa, M, Garcia de Pedro, J, Garcia Rivero, J, Gasplmayr, M, Gebhardt, R, Geldmacher, H, Geltner, C, Gerstlauer, M, Gibson, T, Giuseppe, G, Gogoll, C, Grimm-Sachs, V, Grisle, I, Gruen, B, Gruenewaldt, A, Guarnieri, G, Gullon Blanco, J, Hamelmann, E, Hamerlijnck, D, Hammers-Reinhard, A, Hanon, S, Harzheim, D, Heaney, L, Hellmich, S, Herden, M, Hering, T, Herth, F, Hilberg, O, Howarth, P, Hubatsch, M, Humbert, M, Husemann, K, Idzko, M, Jackson, D, Jandl, M, Jaumont, X, Joos, G, Joest, M, Juech, M, Kabesch, M, Kaiser-Labusch, P, Kardos, P, Kaessner, F, Keeley, T, Kerr, W, Kirschner, J, Klimek, L, Koca, M, Koczulla, R, Koerner-Rettberg, C, Kopac, P, Kronsbein, J, Lipinska, IK, Langer, M, Langeveld, B, Lantz, A, Lazarinis, N, Lazic, Z, Lehtimaki, L, Leuppi, J, Lombardi, C, Lommatzsch, M, Lopez-Vina, A, Luca, R, Ludviksdottir, D, Luettecke-Hecht, C, Macchia, L, Magni, T, Martinez Rivera, C, Mastoridis, P, Mazza, F, Menzella, F, Menzies-Gow, A, Michils, A, Mihaltan, F, Milanese, M, Milger-Kneidinger, K, Molinska, J, Montagna, I, Montuschi, P, Muelleneisen, N, Munoz Esquerre, M, Nanzer-Kelly, A, Nenasheva, N, Neurohr, C, Nucera, E, Otker, J, Oud, K, Paggiaro, P, Parente, R, Parkinson, J, Passalacqua, G, Patberg, N, Patella, V, Patino, O, Paulsson, T, Peche, R, Pelaia, G, Peress, E, Perez de Llano, L, Pfeffer, P, Pfister, P, Pilette, C, Pinedo Sierra, C, Pini, L, Powitz, F, Ranger, T, Rasmussen, L, Rasmussen, K, Rezelj, M, Ricciardi, L, Ricciardolo, F, Ridolo, E, Rijssenbeek-Nouwens, L, Rolla, G, Romero Ribate, D, Ruediger, S, Safioti, G, Sandstrom, T, Santus, P, Sauer, R, Schauerte, G, Schipmann, R, Schleich, F, Schmid, J, Schmidt, F, Schmidt, O, Schmitz, M, Schrag, T, Schroeer, S, Schultz, K, Schulz, C, Scichilone, N, Sedlak, V, Selb, J, Senna, G, Sergejeva, S, Serrano Pariente, J, Sichau, M, Simona, D, Singer, A, Skowasch, D, Smeenk, F, Smith, S, Solidoro, P, Spadaro, G, Spanevello, A, Stefansdottir, M, Steinmetz, K, Steiss, J, Stephan, M, Stieglitz, S, Suhling, H, Taube, C, Yavuz, ST, Tudoric, N, Ulrik, C, van de Ven, M, van den Elshout, F, Van Dyke, M, Van Nederveen-Bendien, S, van Veen, I, Vandenplas, O, Velthove, K, Vianello, A, Vogelberg, C, Wallen-Nielsen, E, Weersink, EJ, Wisskirchen, T, Yacoub, M, Yancey, S, Zappa, M, Zielen, S, Zimmermann, C, Zimmermann, R, van Bragt, JJMH, Adcock, IM, Bel, EHD, Braunstahl, G-J, ten Brinke, A, Busby, J, Canonica, GW, Cao, H, Chung, KF, Csoma, Z, Dahlen, B, Davin, E, Hansen, S, Heffler, E, Horvath, I, Korn, S, Kots, M, Kuna, P, Kwon, N, Louis, R, Plaza, V, Porsbjerg, C, Ramos-Barbon, D, Richards, LB, Skrgat, S, Sont, JK, Vijverberg, SJH, Weersink, EJM, Yasinska, V, Wagers, SS, Djukanovic, R, Maitland-van der Zee, AH, Abenhardt, B, Adler, J, Alfonso, R, Ali, R, Alkameh, S, Almonacid Sanchez, C, Alvares, L, Anderson, G, Assing, K, Ayre, S, Becker, J, Bergmann, K, Bieksiene, K, Bjerring, N, Blasi, F, Bloemen, P, Blum, H, Boeing, S, Bonavia, M, Bossios, A, Bourdin, A, Brons, A, Brusselle, G, Buis, J, Caiaffa, M, Calabrese, C, Camiciottoli, G, Caruso, C, Castilla Martinez, M, Centanni, S, Cisneros Serrano, C, Corsico, A, Cosmi, L, Costantino, M, Costello, R, Crimi, N, Dahlen, S, D'Amato, M, Davies, D, Garcia-Cosio Piqueras, FDB, Decarlo, G, Deimling, A, Del Giacco, S, Diaz Campos, R, Djandji, M, Doberer, D, Dupont, L, Dyett, K, Edelbaher, N, Edelmann, M, Ehmann, R, Ekberg-Jansson, A, Farsi, A, Favero, E, Feimer, J, Fletcher, M, Foschino, B, Frankemolle, B, Gaga, M, Gappa, M, Garcia de Pedro, J, Garcia Rivero, J, Gasplmayr, M, Gebhardt, R, Geldmacher, H, Geltner, C, Gerstlauer, M, Gibson, T, Giuseppe, G, Gogoll, C, Grimm-Sachs, V, Grisle, I, Gruen, B, Gruenewaldt, A, Guarnieri, G, Gullon Blanco, J, Hamelmann, E, Hamerlijnck, D, Hammers-Reinhard, A, Hanon, S, Harzheim, D, Heaney, L, Hellmich, S, Herden, M, Hering, T, Herth, F, Hilberg, O, Howarth, P, Hubatsch, M, Humbert, M, Husemann, K, Idzko, M, Jackson, D, Jandl, M, Jaumont, X, Joos, G, Joest, M, Juech, M, Kabesch, M, Kaiser-Labusch, P, Kardos, P, Kaessner, F, Keeley, T, Kerr, W, Kirschner, J, Klimek, L, Koca, M, Koczulla, R, Koerner-Rettberg, C, Kopac, P, Kronsbein, J, Lipinska, IK, Langer, M, Langeveld, B, Lantz, A, Lazarinis, N, Lazic, Z, Lehtimaki, L, Leuppi, J, Lombardi, C, Lommatzsch, M, Lopez-Vina, A, Luca, R, Ludviksdottir, D, Luettecke-Hecht, C, Macchia, L, Magni, T, Martinez Rivera, C, Mastoridis, P, Mazza, F, Menzella, F, Menzies-Gow, A, Michils, A, Mihaltan, F, Milanese, M, Milger-Kneidinger, K, Molinska, J, Montagna, I, Montuschi, P, Muelleneisen, N, Munoz Esquerre, M, Nanzer-Kelly, A, Nenasheva, N, Neurohr, C, Nucera, E, Otker, J, Oud, K, Paggiaro, P, Parente, R, Parkinson, J, Passalacqua, G, Patberg, N, Patella, V, Patino, O, Paulsson, T, Peche, R, Pelaia, G, Peress, E, Perez de Llano, L, Pfeffer, P, Pfister, P, Pilette, C, Pinedo Sierra, C, Pini, L, Powitz, F, Ranger, T, Rasmussen, L, Rasmussen, K, Rezelj, M, Ricciardi, L, Ricciardolo, F, Ridolo, E, Rijssenbeek-Nouwens, L, Rolla, G, Romero Ribate, D, Ruediger, S, Safioti, G, Sandstrom, T, Santus, P, Sauer, R, Schauerte, G, Schipmann, R, Schleich, F, Schmid, J, Schmidt, F, Schmidt, O, Schmitz, M, Schrag, T, Schroeer, S, Schultz, K, Schulz, C, Scichilone, N, Sedlak, V, Selb, J, Senna, G, Sergejeva, S, Serrano Pariente, J, Sichau, M, Simona, D, Singer, A, Skowasch, D, Smeenk, F, Smith, S, Solidoro, P, Spadaro, G, Spanevello, A, Stefansdottir, M, Steinmetz, K, Steiss, J, Stephan, M, Stieglitz, S, Suhling, H, Taube, C, Yavuz, ST, Tudoric, N, Ulrik, C, van de Ven, M, van den Elshout, F, Van Dyke, M, Van Nederveen-Bendien, S, van Veen, I, Vandenplas, O, Velthove, K, Vianello, A, Vogelberg, C, Wallen-Nielsen, E, Weersink, EJ, Wisskirchen, T, Yacoub, M, Yancey, S, Zappa, M, Zielen, S, Zimmermann, C, and Zimmermann, R

Abstract

Little is known about the characteristics and treatments of patients with severe asthma across Europe, but both are likely to vary. This is the first study in the European Respiratory Society Severe Heterogeneous Asthma Research collaboration, Patient-centred (SHARP) Clinical Research Collaboration and it is designed to explore these variations. Therefore, we aimed to compare characteristics of patients in European severe asthma registries and treatments before starting biologicals.This was a cross-sectional retrospective analysis of aggregated data from 11 national severe asthma registries that joined SHARP with established patient databases.Analysis of data from 3236 patients showed many differences in characteristics and lifestyle factors. Current smokers ranged from 0% (Poland and Sweden) to 9.5% (Belgium), mean body mass index ranged from 26.2 (Italy) to 30.6 kg·m-2 (the UK) and the largest difference in mean pre-bronchodilator forced expiratory volume in 1 s % predicted was 20.9% (the Netherlands versus Hungary). Before starting biologicals patients were treated differently between countries: mean inhaled corticosteroid dose ranged from 700 to 1335 µg·day-1 between those from Slovenia versus Poland when starting anti-interleukin (IL)-5 antibody and from 772 to 1344 µg·day-1 in those starting anti-IgE (Slovenia versus Spain). Maintenance oral corticosteroid use ranged from 21.0% (Belgium) to 63.0% (Sweden) and from 9.1% (Denmark) to 56.1% (the UK) in patients starting anti-IL-5 and anti-IgE, respectively.The severe asthmatic population in Europe is heterogeneous and differs in both clinical characteristics and treatment, often appearing not to comply with the current European Respiratory Society/American Thoracic Society guidelines definition of severe asthma. Treatment regimens before starting biologicals were different from inclusion criteria in clinical trials and varied between countries.

Published
2020

13. Inleiding

Author

de Jongh, T.O.H., primary, Buis, J., additional, Daelmans, H.E.M., additional, Dekker, M.J., additional, and de Loor, J.D., additional

Published
2012
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17. Characteristics and treatment regimens across ERS SHARP severe asthma registries

Author

van Bragt, JJMH, Adcock, IM, Bel, EHD, Braunstahl, GJ, ten Brinke, A, Busby, J, Canonica, GW, Cao, H, Chung, KF, Csoma, Z, Dahlen, B, Davin, E, Hansen, S, Heffler, E, Horvath, I, Korn, S, Kots, M, Kuna, P, Kwon, N, Louis, R, Plaza, V, Porsbjerg, C, Ramos-Barbon, D, Richards, LB, Skrgat, S, Sont, JK, Vijverberg, SJH, Weersink, EJM, Yasinska, V, Wagers, SS, Djukanovic, R, Maitland-van der Zee, AH, Abenhardt, B, Adler, J, Alfonso, R, Ali, R, Alkameh, S, Sanchez, CA, Alvares, L, Anderson, G, Assing, K, Ayre, S, Becker, J, Bergmann, K, Bieksiene, K, Bjerring, N, Blasi, F, Bloemen, P, Blum, H, Boing, S, Bonavia, M, Bossios, A, Bourdin, A, Brons, A, Brusselle, G, Buis, J, Caiaffa, M, Calabrese, C, Camiciottoli, G, Caruso, C, Martinez, MC, Centanni, S, Serrano, CC, Corsico, A, Cosmi, L, Costantino, M, Costello, R, Crimi, N, Dahlen, S, D'Amato, M, Davies, D, Piqueras, FDGC, Decarlo, G, Deimling, A, Del Giacco, S, Campos, RD, Djandji, M, Doberer, D, Dupont, L, Dyett, K, Edelbaher, N, Edelmann, M, Ehmann, R, Ekberg-Jansson, A, Farsi, A, Favero, E, Feimer, J, Fletcher, M, Foschino, B, Frankemolle, B, Gaga, M, Gappa, M, de Pedro, JG, Rivero, JG, Gasplmayr, M, Gebhardt, R, Geldmacher, H, Geltner, C, Gerstlauer, M, Gibson, T, Giuseppe, G, Gogoll, C, Grimm-Sachs, V, Grisle, I, Grun, B, Grunewaldt, A, Guarnieri, G, Blanco, JG, Hamelmann, E, Hamerlijnck, D, Hammers-Reinhard, A, Hanon, S, Harzheim, D, Heaney, L, Hellmich, S, Herden, M, Hering, T, Herth, F, Hilberg, O, Howarth, P, Hubatsch, M, Humbert, M, Husemann, K, Idzko, M, Jackson, D, Jandl, M, Jaumont, X, Joos, G, Jost, M, Juch, M, Kabesch, M, Kaiser-Labusch, P, Kardos, P, Kassner, F, Keeley, T, Kerr, W, Kirschner, J, Klimek, L, Koca, M, Koczulla, R, Koerner-Rettberg, C, Kopac, P, Kronsbein, J, Lipinska, IK, Langer, M, Langeveld, B, Lantz, A, Lazarinis, N, Lazic, Z, Lehtimaki, L, Leuppi, J, Lombardi, C, Lommatzsch, M, Lopez-Vina, A, Luca, R, Ludviksdottir, D, Luttecke-Hecht, C, Macchia, L, Magni, T, Rivera, CM, Mastoridis, P, Mazza, F, Menzella, F, Menzies-Gow, A, Michils, A, Mihaltan, F, Milanese, M, Milger-Kneidinger, K, Molinska, J, Montagna, I, Montuschi, P, Mulleneisen, N, Esquerre, MM, Nanzer-Kelly, A, Nenasheva, N, Neurohr, C, Nucera, E, Otker, J, Oud, K, Paggiaro, P, Parente, R, Parkinson, J, Passalacqua, G, Patberg, N, Patella, V, Patino, O, Paulsson, T, Peche, R, Pelaia, G, Peress, E, de Llano, LP, Pfeffer, P, Pfister, P, Pilette, C, Sierra, CP, Pini, L, Powitz, F, Ranger, T, Rasmussen, L, Rasmussen, K, Rezelj, M, Ricciardi, L, Ricciardolo, F, Ridolo, E, Rijssenbeek-Nouwens, L, Rolla, G, Ribate, DR, Rudiger, S, Safioti, G, Sandstrom, T, Santus, P, Sauer, R, Schauerte, G, Schipmann, R, Schleich, F, Schmid, J, Schmidt, F, Schmidt, O, Schmitz, M, Schrag, T, Schroer, S, Schultz, K, Schulz, C, Scichilone, N, Sedlak, V, Selb, J, Senna, G, Sergejeva, S, Pariente, JS, Sichau, M, Simona, D, Singer, A, Skowasch, D, Smeenk, F, Smith, S, Solidoro, P, Spadaro, G, Spanevello, A, Stefansdottir, M, Steinmetz, K, Steiss, J, Stephan, M, Stieglitz, S, Suhling, H, Taube, C, Yavuz, ST, Tudoric, N, Ulrik, C, van de Ven, M, van den Elshout, F, Van Dyke, M, Van Nederveen-Bendien, S, van Veen, I, Vandenplas, O, Velthove, K, Vianello, A, Vogelberg, C, Wallen-Nielsen, E, Weersink, EJ, Wisskirchen, T, Yacoub, M, Yancey, S, Zappa, M, Zielen, S, Zimmermann, C, Zimmermann, R, Graduate School, AII - Inflammatory diseases, APH - Personalized Medicine, Pulmonology, Paediatric Pulmonology, van Bragt, J. J. M. H., Adcock, I. M., Bel, E. H. D., Braunstahl, G. -J., ten Brinke, A., Busby, J., Canonica, G. W., Cao, H., Chung, K. F., Csoma, Z., Dahlen, B., Davin, E., Hansen, S., Heffler, E., Horvath, I., Korn, S., Kots, M., Kuna, P., Kwon, N., Louis, R., Plaza, V., Porsbjerg, C., Ramos-Barbon, D., Richards, L. B., Skrgat, S., Sont, J. K., Vijverberg, S. J. H., Weersink, E. J. M., Yasinska, V., Wagers, S. S., Djukanovic, R., Maitland-Van der Zee, A. H., Abenhardt, B., Adler, J., Alfonso, R., Ali, R., Alkameh, S., Almonacid Sanchez, C., Alvares, L., Anderson, G., Assing, K., Ayre, S., Becker, J., Bergmann, K., Bieksiene, K., Bjerring, N., Blasi, F., Bloemen, P., Blum, H., Boing, S., Bonavia, M., Bossios, A., Bourdin, A., Brons, A., Brusselle, G., Buis, J., Caiaffa, M., Calabrese, C., Camiciottoli, G., Caruso, C., Castilla Martinez, M., Centanni, S., Cisneros Serrano, C., Corsico, A., Cosmi, L., Costantino, M., Costello, R., Crimi, N., Dahlen, S., D'Amato, M., Davies, D., de Borja Garcia-Cosio Piqueras, F., Decarlo, G., Deimling, A., Del Giacco, S., Diaz Campos, R., Djandji, M., Doberer, D., Dupont, L., Dyett, K., Edelbaher, N., Edelmann, M., Ehmann, R., Ekberg-Jansson, A., Farsi, A., Favero, E., Feimer, J., Fletcher, M., Foschino, B., Frankemolle, B., Gaga, M., Gappa, M., Garcia de Pedro, J., Garcia Rivero, J., Gasplmayr, M., Gebhardt, R., Geldmacher, H., Geltner, C., Gerstlauer, M., Gibson, T., Giuseppe, G., Gogoll, C., Grimm-Sachs, V., Grisle, I., Grun, B., Grunewaldt, A., Guarnieri, G., Gullon Blanco, J., Hamelmann, E., Hamerlijnck, D., Hammers-Reinhard, A., Hanon, S., Harzheim, D., Heaney, L., Hellmich, S., Herden, M., Hering, T., Herth, F., Hilberg, O., Howarth, P., Hubatsch, M., Humbert, M., Husemann, K., Idzko, M., Jackson, D., Jandl, M., Jaumont, X., Joos, G., Jost, M., Juch, M., Kabesch, M., Kaiser-Labusch, P., Kardos, P., Kassner, F., Keeley, T., Kerr, W., Kirschner, J., Klimek, L., Koca, M., Koczulla, R., Koerner-Rettberg, C., Kopac, P., Kronsbein, J., Kuprys Lipinska, I., Langer, M., Langeveld, B., Lantz, A., Lazarinis, N., Lazic, Z., Lehtimaki, L., Leuppi, J., Lombardi, C., Lommatzsch, M., Lopez-Vina, A., Luca, R., Ludviksdottir, D., Luttecke-Hecht, C., Macchia, L., Magni, T., Martinez Rivera, C., Mastoridis, P., Mazza, F., Menzella, F., Menzies-Gow, A., Michils, A., Mihalthan, F., Milanese, M., Milger-Kneidinger, K., Molinska, J., Montagna, I., Montuschi, P., Mulleneisen, N., Munoz Esquerre, M., Nanzer-Kelly, A., Nenasheva, N., Neurohr, C., Nucera, E., Otker, J., Oud, K., Paggiaro, P., Parente, R., Parkinson, J., Passalacqua, G., Patberg, N., Patella, V., Patino, O., Paulsson, T., Peche, R., Pelaia, G., Peress, E., Perez de Llano, L., Pfeffer, P., Pfister, P., Pilette, C., Pinedo Sierra, C., Pini, L., Powitz, F., Ranger, T., Rasmussen, L., Rasmussen, K., Rezelj, M., Ricciardi, L., Ricciardolo, F., Ridolo, E., Rijssenbeek-Nouwens, L., Rolla, G., Romero Ribate, D., Rudiger, S., Safioti, G., Sandstrom, T., Santus, P., Sauer, R., Schauerte, G., Schipmann, R., Schleich, F., Schmid, J., Schmidt, F., Schmidt, O., Schmitz, M., Schrag, T., Schroer, S., Schultz, K., Schulz, C., Scichilone, N., Sedlak, V., Selb, J., Senna, G., Sergejeva, S., Serrano Pariente, J., Sichau, M., Simona, D., Singer, A., Skowasch, D., Smeenk, F., Smith, S., Solidoro, P., Spadaro, G., Spanevello, A., Stefansdottir, M., Steinmetz, K., Steiss, J., Stephan, M., Stieglitz, S., Suhling, H., Taube, C., Tolga Yavuz, S., Tudoric, N., Ulrik, C., van de Ven, M., van den Elshout, F., van Dyke, M., van Nederveen-Bendien, S., van Veen, I., Vandenplas, O., Velthove, K., Vianello, A., Vogelberg, C., Wallen-Nielsen, E., Wisskirchen, T., Yacoub, M., Yancey, S., Zappa, M., Zielen, S., Zimmermann, C., Zimmermann, R., UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, van Bragt J.J.M.H., Adcock I.M., Bel E.H.D., Braunstahl G.-J., ten Brinke A., Busby J., Canonica G.W., Cao H., Chung K.F., Csoma Z., Dahlen B., Davin E., Hansen S., Heffler E., Horvath I., Korn S., Kots M., Kuna P., Kwon N., Louis R., Plaza V., Porsbjerg C., Ramos-Barbon D., Richards L.B., Skrgat S., Sont J.K., Vijverberg S.J.H., Weersink E.J.M., Yasinska V., Wagers S.S., Djukanovic R., Maitland-Van der Zee A.H., Abenhardt B., Adler J., Alfonso R., Ali R., Alkameh S., Almonacid Sanchez C., Alvares L., Anderson G., Assing K., Ayre S., Becker J., Bergmann K., Bieksiene K., Bjerring N., Blasi F., Bloemen P., Blum H., Boing S., Bonavia M., Bossios A., Bourdin A., Brons A., Brusselle G., Buis J., Caiaffa M., Calabrese C., Camiciottoli G., Caruso C., Castilla Martinez M., Centanni S., Cisneros Serrano C., Corsico A., Cosmi L., Costantino M., Costello R., Crimi N., Dahlen S., D'Amato M., Davies D., de Borja Garcia-Cosio Piqueras F., Decarlo G., Deimling A., Del Giacco S., Diaz Campos R., Djandji M., Doberer D., Dupont L., Dyett K., Edelbaher N., Edelmann M., Ehmann R., Ekberg-Jansson A., Farsi A., Favero E., Feimer J., Fletcher M., Foschino B., Frankemolle B., Gaga M., Gappa M., Garcia de Pedro J., Garcia Rivero J., Gasplmayr M., Gebhardt R., Geldmacher H., Geltner C., Gerstlauer M., Gibson T., Giuseppe G., Gogoll C., Grimm-Sachs V., Grisle I., Grun B., Grunewaldt A., Guarnieri G., Gullon Blanco J., Hamelmann E., Hamerlijnck D., Hammers-Reinhard A., Hanon S., Harzheim D., Heaney L., Hellmich S., Herden M., Hering T., Herth F., Hilberg O., Howarth P., Hubatsch M., Humbert M., Husemann K., Idzko M., Jackson D., Jandl M., Jaumont X., Joos G., Jost M., Juch M., Kabesch M., Kaiser-Labusch P., Kardos P., Kassner F., Keeley T., Kerr W., Kirschner J., Klimek L., Koca M., Koczulla R., Koerner-Rettberg C., Kopac P., Kronsbein J., Kuprys Lipinska I., Langer M., Langeveld B., Lantz A., Lazarinis N., Lazic Z., Lehtimaki L., Leuppi J., Lombardi C., Lommatzsch M., Lopez-Vina A., Luca R., Ludviksdottir D., Luttecke-Hecht C., Macchia L., Magni T., Martinez Rivera C., Mastoridis P., Mazza F., Menzella F., Menzies-Gow A., Michils A., Mihalthan F., Milanese M., Milger-Kneidinger K., Molinska J., Montagna I., Montuschi P., Mulleneisen N., Munoz Esquerre M., Nanzer-Kelly A., Nenasheva N., Neurohr C., Nucera E., Otker J., Oud K., Paggiaro P., Parente R., Parkinson J., Passalacqua G., Patberg N., Patella V., Patino O., Paulsson T., Peche R., Pelaia G., Peress E., Perez de Llano L., Pfeffer P., Pfister P., Pilette C., Pinedo Sierra C., Pini L., Powitz F., Ranger T., Rasmussen L., Rasmussen K., Rezelj M., Ricciardi L., Ricciardolo F., Ridolo E., Rijssenbeek-Nouwens L., Rolla G., Romero Ribate D., Rudiger S., Safioti G., Sandstrom T., Santus P., Sauer R., Schauerte G., Schipmann R., Schleich F., Schmid J., Schmidt F., Schmidt O., Schmitz M., Schrag T., Schroer S., Schultz K., Schulz C., Scichilone N., Sedlak V., Selb J., Senna G., Sergejeva S., Serrano Pariente J., Sichau M., Simona D., Singer A., Skowasch D., Smeenk F., Smith S., Solidoro P., Spadaro G., Spanevello A., Stefansdottir M., Steinmetz K., Steiss J., Stephan M., Stieglitz S., Suhling H., Taube C., Tolga Yavuz S., Tudoric N., Ulrik C., van de Ven M., van den Elshout F., van Dyke M., van Nederveen-Bendien S., van Veen I., Vandenplas O., Velthove K., Vianello A., Vogelberg C., Wallen-Nielsen E., Wisskirchen T., Yacoub M., Yancey S., Zappa M., Zielen S., Zimmermann C., Zimmermann R., Amsterdam UMC, National Heart and Lung Institute [London] (NHLI), Imperial College London-Royal Brompton and Harefield NHS Foundation Trust, Department of Medical Microbiology and Infection Control, Franciscus Gasthuis & Vlietland, Kleiweg 500, 3045 PM, Rotterdam, The Netherlands., Medical Centre Leeuwarden, Queen's University [Belfast] (QUB), Humanitas University [Milan] (Hunimed), Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA, Korányi National Institute of Pulmonology (OKPI), Karolinska University Hospital [Stockholm], The European Lung Foundation (ELF), Bispebjerg and Frederiksberg Hospitals, Humanitas Clinical and Research Center [Rozzano, Milan, Italy], University Medical Center of the Johannes Gutenberg-University Mainz, Chiesi Farmaceutici, Medical University of Łódź (MUL), GlaxoSmithKline, Brentford, Middlesex, Centre Hospitalier Universitaire de Liège (CHU-Liège), Hospital de la Santa Creu i Sant Pau, Copenhagen University Hospital, Respiratory and Allergic Diseases [Golnik, Slovenia], University Clinic of Respiratory and Allergic Diseases Golnik, Leiden University Medical Center (LUMC), Biosci Consulting, University Hospital Southampton NHS Foundation Trust, SHARP Clinical Research, Hôpital Arnaud de Villeneuve [CHRU Montpellier], and Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)

Subjects
Severe asthma, Pediatrics, MESH: Registries, MESH: Asthma, Cross-sectional study, Respiratory System, Medizin, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, 0302 clinical medicine, MESH: Belgium, Belgium, Medicine research, Anti-Asthmatic Agents, Registries, 030212 general & internal medicine, [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology, 10. No inequality, 11 Medical and Health Sciences, Netherlands, 2. Zero hunger, education.field_of_study, SHARP CRC, MESH: Administration, Inhalation, MESH: Anti-Asthmatic Agents, 3. Good health, Europe, Italy, MESH: Poland, MESH: Sweden, medicine.drug, Pulmonary and Respiratory Medicine, medicine.medical_specialty, MESH: Hungary, Population, Investigació mèdica, Settore MED/10 - Malattie Dell'Apparato Respiratorio, 03 medical and health sciences, MESH: Cross-Sectional Studies, Administration, Inhalation, MESH: Spain, medicine, Humans, education, Asma, Retrospective Studies, Asthma, Sweden, Hungary, MESH: Humans, business.industry, Settore MED/09 - MEDICINA INTERNA, MESH: Italy, MESH: Retrospective Studies, Retrospective cohort study, Original Articles, asthma, medicine.disease, Clinical trial, Cross-Sectional Studies, Clinical research, 030228 respiratory system, Spain, MESH: Netherlands, MESH: Europe, Poland, business, Body mass index, Mepolizumab
Abstract

Little is known about the characteristics and treatments of patients with severe asthma across Europe, but both are likely to vary. This is the first study in the European Respiratory Society Severe Heterogeneous Asthma Research collaboration, Patient-centred (SHARP) Clinical Research Collaboration and it is designed to explore these variations. Therefore, we aimed to compare characteristics of patients in European severe asthma registries and treatments before starting biologicals.This was a cross-sectional retrospective analysis of aggregated data from 11 national severe asthma registries that joined SHARP with established patient databases.Analysis of data from 3236 patients showed many differences in characteristics and lifestyle factors. Current smokers ranged from 0% (Poland and Sweden) to 9.5% (Belgium), mean body mass index ranged from 26.2 (Italy) to 30.6 kg·m−2 (the UK) and the largest difference in mean pre-bronchodilator forced expiratory volume in 1 s % predicted was 20.9% (the Netherlands versus Hungary). Before starting biologicals patients were treated differently between countries: mean inhaled corticosteroid dose ranged from 700 to 1335 µg·day−1 between those from Slovenia versus Poland when starting anti-interleukin (IL)-5 antibody and from 772 to 1344 µg·day−1 in those starting anti-IgE (Slovenia versus Spain). Maintenance oral corticosteroid use ranged from 21.0% (Belgium) to 63.0% (Sweden) and from 9.1% (Denmark) to 56.1% (the UK) in patients starting anti-IL-5 and anti-IgE, respectively.The severe asthmatic population in Europe is heterogeneous and differs in both clinical characteristics and treatment, often appearing not to comply with the current European Respiratory Society/American Thoracic Society guidelines definition of severe asthma. Treatment regimens before starting biologicals were different from inclusion criteria in clinical trials and varied between countries.

Published
2019

21. Multi-band automatic sun and sky scanning radiometer system for measurement of aerosols

Author

Holben, B. N, Eck, T. F, Slutsker, I, Tanre, D, Buis, J. P, Setzer, A, Vermote, E, Reagan, J. A, and Kaufman, Y. A

Subjects
Earth Resources And Remote Sensing
Abstract

A weather resistant automatic scanning Sun photometer system is assessed and demonstrated as practical for measurements of aerosol concentrations and properties at remote sites. Interfaced with a transmitter using the Geostationary Data Collection System (GDCS), the data are processed in near real time. The processing allows a time dependence of the aerosols and water vapor and an ongoing assessment of the health and calibration of the instruments. The system's automatic data acquisition, transmission, and processing offer immediate application to atmospheric monitoring and modeling on a regional to global scale and validation of satellite retrievals. It is estimated that under normal circumstances the retrieved aerosol optical thickness has a network wide accuracy of +/- 0.02 from 340 nm to 1020 nm, water vapor +/- 0.2 cm and size distribution from 0.1 to 3 micrometers.

Published
1994

22. Intrinsic limits on resolutions in muon and electron-neutrino charged-current events in the KM3NeT/ORCA detector

Author

The KM3NeT collaboration, Adrián, Martínez, Ageron, S., Aiello, M., Albert, S., Ameli, A., Anassontzis, F., E. G., Andre, Androulakis, M., Anghinolfi, G., Anton, M., Ardid, G., Avgitas, M., Barbarino, T., Barbarito, G., Baret, E., Barrios, Mart, Belias, J., Berbee, A., van den Berg, Bertin, A., Beurthey, V., Van, Beveren, Beverini, V., Biagi, N., Biagioni, S., Billault, A., Bondì, M., Bormuth, M., Bouhadef, R., Bourlis, B., Bourret, G., Boutonnet, S., Bouwhuis, C., Bozza, M., Bruijn, C., Brunner, R., Buis, J., Buompane, E., Busto, R., Cacopardo, J., Caillat, G., Calamai, L., Calvo, M., Capone, D., Caramete, A., Cecchini, L., Celli, S., Champion, S., Cherubini, Silvio, Chiarella, V., Chiarelli, L., Chiarusi, T., Circella, M., Classen, L., Cobas, D., Cocimano, R., Coelho, J. A. B., Coleiro, A., Colonges, S., Coniglione, R., Cordelli, M., Cosquer, A., Coyle, P., Creusot, A., Cuttone, G., D’Amato, C., D’Amico, A., D’Onofrio, A., Bonis, De, Sio, De, Palma, Di, Díaz, I., A. F., Distefano, Donzaud, C., Dornic, C., Dorosti, Hasankiadeh, Drakopoulou, Q., Drouhin, E., Durocher, D., Eberl, M., Eichie, T., Van, Eijk, Bojaddaini, El, Elsaesser, I., Enzenhöfer, D., Favaro, A., Fermani, M., Ferrara, P., Frascadore, G., Furini, G., Fusco, M., L. A., Gal, Galatà, T., Garufi, S., Gay, F., Gebyehu, P., Giacomini, M., Gialanella, F., Giordano, L., Gizani, V., Gracia, N., Graf, R., Grégoire, K., Grella, T., Grmek, G., Guerzoni, A., Habel, M., Hallmann, R., Van, Haren, Harissopulos, H., Heid, S., Heijboer, T., Heine, A., Henry, E., Hernández, Rey, J. J., Hevinga, Hofestädt, M., Hugon, J., C. M. F., Illuminati, James, G., C. W., Jansweijerf, Jongen, P., Jong, De, Kadler, M., Kalekin, M., Kappes, O., Katz, A., U. F., Keller, Kieft, P., Kießling, G., Koffeman, D., E. N., Kooijman, Kouchner, P., Kreter, A., Kulikovskiy, M., Lahmann, V., Lamare, R., Larosa, P., Leisos, G., Leone, Francesco, Leonora, E., Lindsey, Clark, Liolios, M., Llorens, Alvarez, C. D., LO PRESTI, Domenico, Löhner, H., Lonardo, A., Lotze, M., Loucatos, S., Maccioni, E., Mannheim, K., Manzali, M., Margiotta, A., Margotti, A., Marinelli, A., Maris, O., Markou, C., Martínez, Mora, J. A., Martini, Marzaioli, A., Mele, F., Melis, R., K. W., Michael, Migliozzi, T., Migneco, P., Mijakowski, E., Miraglia, P., Mollo, A., C. M., Mongelli, Morganti, M., Moussa, M., Musico, A., Musumeci, P., Navas, M., Nicolau, S., C. A., Olcina, Olivetto, I., Orlando, C., Orzelli, A., Pancaldi, A., Papaikonomou, G., Papaleo, A., Păvălas, R., G. E., Peek, Pellegrini, H., Pellegrino, G., Perrina, C., Pfutzner, C., Piattelli, M., Pikounis, P., Pleinert, K., M. O., Poma, G. E., Popa, Pradier, V., Pratolongo, T., Pühlhofer, F., Pulvirenti, G., Quinn, S., Racca, L., Raffaelli, C., Randazzo, F., Rauch, N., Real, T., Resvanis, D., Reubelt, L., Riccobene, J., Rossi, G., Rovelli, C., Saldaña, A., Salvadori, M., Samtleben, I., D. F. E., Sánchez, García, Sánchez, Losa, Sanguineti, A., Santangelo, M., Santonocito, A., Sapienza, D., Schimmel, P., Schmelling, F., Schnabel, J., Sciacca, J., Sedita, V., Seitz, M., Sgura, T., Simeone, I., Sipala, F., Spisso, V., Spurio, B., Stavropoulos, M., Steijger, G., Stellacci, J., S. M., Stransky, Taiuti, D., Tayalati, M., Terrasi, Y., Tézier, F., Theraube, D., Timmer, S., Tönnis, P., Trasatti, C., Travaglini, L., Trovato, R., Tsirigotis, A., Tzamarias, A., Tzamariudaki, S., Vallage, E., Van, Elewyck, Vermeulen, V., Versari, J., Vicini, F., Viola, P., Vivolo, S., Volkert, D., Wiggers, M., Wilms, L., Wolf, De, Zachariadou, E., Zani, K., Zornoza, S., J. D., Zúñiga, KM3NeT (IHEF, IoP, FNWI), ATLAS (IHEF, IoP, FNWI), Research unit Astroparticle Physics, Research unit Nuclear & Hadron Physics, Adrian-Martinez, S, Ageron, M, Aiello, S, Albert, A, Ameli, F, Anassontzis, Eg, Andre, M, Androulakis, G, Anghinolfi, M, Anton, G, Ardid, M, Avgitas, T, Barbarino, G, Barbarito, E, Baret, B, Barrios-Marti, J, Belias, A, Berbee, E, van den Berg, A, Bertin, V, Beurthey, S, van Beveren, V, Beverini, N, Biagi, S, Biagioni, A, Billault, M, Bondi, M, Bormuth, R, Bouhadef, B, Bourlis, G, Bourret, S, Boutonnet, C, Bouwhuis, M, Bozza, C, Bruijn, R, Brunner, J, Buis, E, Buompane, R, Busto, J, Cacopardo, G, Caillat, L, Calamai, M, Calvo, D, Capone, A, Caramete, L, Cecchini, S, Celli, S, Champion, C, Cherubini, S, Chiarella, V, Chiarelli, L, Chiarusi, T, Circella, M, Classen, L, Cobas, D, Cocimano, R, Coelho, Jab, Coleiro, A, Colonges, S, Coniglione, R, Cordelli, M, Cosquer, A, Coyle, P, Creusot, A, Cuttone, G, D'Amato, C, D'Amico, A, D'Onofrio, A, De Bonis, G, De Sio, C, Di Palma, I, Diaz, Af, Distefano, C, Donzaud, C, Dornic, D, Dorosti-Hasankiadeh, Q, Drakopoulou, E, Drouhin, D, Durocher, M, Eberl, T, Eichie, S, van Eijk, D, El Bojaddaini, I, Elsaesser, D, Enzenhofer, A, Favaro, M, Fermani, P, Ferrara, G, Frascadore, G, Furini, M, Fusco, La, Gal, T, Galata, S, Garufi, F, Gay, P, Gebyehu, M, Giacomini, F, Gialanella, L, Giordano, V, Gizani, N, Gracia, R, Graf, K, Gregoire, T, Grella, G, Grmek, A, Guerzoni, M, Habel, R, Hallmann, S, van Haren, H, Harissopulos, S, Heid, T, Heijboer, A, Heine, E, Henry, S, Hernandez-Rey, Jj, Hevinga, M, Hofestadt, J, Hugon, Cmf, Illuminati, G, James, Cw, Jansweijer, P, Jongen, M, de Jong, M, Kadler, M, Kalekin, O, Kappes, A, Katz, Uf, Keller, P, Kieft, G, Kiessling, D, Koffeman, En, Kooijman, P, Kouchner, A, Kreter, M, Kulikovskiy, V, Lahmann, R, Lamare, P, Larosa, G, Leisos, A, Leone, F, Leonora, E, Clark, Ml, Liolios, A, Alvarez, Cdl, Lo Presti, D, Lohner, H, Lonardo, A, Lotze, M, Loucatos, S, Maccioni, E, Mannheim, K, Manzali, M, Margiotta, A, Margotti, A, Marinelli, A, Maris, O, Markou, C, Martinez-Mora, Ja, Martini, A, Marzaioli, F, Mele, R, Melis, Kw, Michael, T, Migliozzi, P, Migneco, E, Mijakowski, P, Miraglia, A, Mollo, Cm, Mongelli, M, Morganti, M, Moussa, A, Musico, P, Musumeci, M, Navas, S, Nicolau, Ca, Olcina, I, Olivetto, C, Orlando, A, Orzelli, A, Pancaldi, G, Papaikonomou, A, Papaleo, R, Pavalas, Ge, Peek, H, Pellegrini, G, Pellegrino, C, Perrina, C, Pfutzner, M, Piattelli, P, Pikounis, K, Pleinert, Mo, Poma, Ge, Popa, V, Pradier, T, Pratolongo, F, Puhlhofer, G, Pulvirenti, S, Quinn, L, Racca, C, Raffaelli, F, Randazzo, N, Rauch, T, Real, D, Resvanis, L, Reubelt, J, Riccobene, G, Rossi, C, Rovelli, A, Saldana, M, Salvadori, I, Samtleben, Dfe, Garcia, A, Losa, A, Sanguineti, M, Santangelo, A, Santonocito, D, Sapienza, P, Schimmel, F, Schmelling, J, Schnabel, J, Sciacca, V, Sedita, M, Seitz, T, Sgura, I, Simeone, F, Sipala, V, Spisso, B, Spurio, M, Stavropoulos, G, Steijger, J, Stellacci, Sm, Stransky, D, Taiuti, M, Tayalati, Y, Terrasi, F, Tezier, D, Theraube, S, Timmer, P, Tonnis, C, Trasatti, L, Travaglini, R, Trovato, A, Tsirigotis, A, Tzamarias, S, Tzamariudaki, E, Vallage, B, Van Elewyck, V, Vermeulen, J, Versari, F, Vicini, P, Viola, S, Vivolo, D, Volkert, M, Wiggers, L, Wilms, J, de Wolf, E, Zachariadou, K, Zani, S, Zornoza, Jd, Zuniga, J, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), KM3NeT, Centre Tecnològic de Vilanova i la Geltrú, Universitat Politècnica de Catalunya. LAB - Laboratori d'Aplicacions Bioacústiques, Adrián Martínez, S., Ageron, M., Aiello, S., Albert, A., Ameli, F., Anassontzis, E. G., Andre, M., Androulakis, G., Anghinolfi, M., Anton, G., Ardid, M., Avgitas, T., Barbarino, G., Barbarito, E., Baret, B., Barrios Mart, J., Belias, A., Berbee, E., van den Berg, A., Bertin, V., Beurthey, S., van Beveren, V., Beverini, N., Biagi, S., Biagioni, A., Billault, M., Bondì, M., Bormuth, R., Bouhadef, B., Bourlis, G., Bourret, S., Boutonnet, C., Bouwhuis, M., Bozza, C., Bruijn, R., Brunner, J., Buis, E., Buompane, R., Busto, J., Cacopardo, G., Caillat, L., Calamai, M., Calvo, D., Capone, A., Caramete, L., Cecchini, S., Celli, S., Champion, C., Cherubini, S., Chiarella, V., Chiarelli, L., Chiarusi, T., Circella, M., Classen, L., Cobas, D., Cocimano, R., Coelho, J. A. B., Coleiro, A., Colonges, S., Coniglione, R., Cordelli, M., Cosquer, A., Coyle, P., Creusot, A., Cuttone, G., D’Amato, C., D’Amico, A., D'Onofrio, Antonio, De Bonis, G., De Sio, C., Di Palma, I., Díaz, A. F., Distefano, C., Donzaud, C., Dornic, D., Dorosti Hasankiadeh, Q., Drakopoulou, E., Drouhin, D., Durocher, M., Eberl, T., Eichie, S., van Eijk, D., El Bojaddaini, I., Elsaesser, D., Enzenhöfer, A., Favaro, M., Fermani, P., Ferrara, G., Frascadore, G., Furini, M., Fusco, L. A., Gal, T., Galatà, S., Garufi, F., Gay, P., Gebyehu, M., Giacomini, F., Gialanella, Lucio, Giordano, V., Gizani, N., Gracia, R., Graf, K., Grégoire, T., Grella, G., Grmek, A., Guerzoni, M., Habel, R., Hallmann, S., van Haren, H., Harissopulos, S., Heid, T., Heijboer, A., Heine, E., Henry, S., Hernández Rey, J. J., Hevinga, M., Hofestädt, J, Hugon, C. M. F., Illuminati, G., James, C. W., Jansweijerf, P., Jongen, M., de Jong, M., Kadler, M., Kalekin, O., Kappes, A., Katz, U. F., Keller, P., Kieft, G., Kießling, D., Koffeman, E. N., Kooijman, P., Kouchner, A., Kreter, M., Kulikovskiy, V., Lahmann, R., Lamare, P., Larosa, G., Leisos, A., Leone, F., Leonora, E., Lindsey Clark, M., Liolios, A., Llorens Alvarez, C. D., Lo Presti, D., Löhner, H., Lonardo, A., Lotze, M., Loucatos, S., Maccioni, E., Mannheim, K., Manzali, M., Margiotta, A., Margotti, A., Marinelli, A., Maris, O., Markou, C., Martínez Mora, J. A., Martini, A., Marzaioli, Fabio, Mele, R., Melis, K. W., Michael, T., Migliozzi, P., Migneco, E., Mijakowski, P., Miraglia, A., Mollo, C. M., Mongelli, M., Morganti, M., Moussa, A., Musico, P., Musumeci, M., Navas, S., Nicolau, C. A., Olcina, I., Olivetto, C., Orlando, Antonio, Orzelli, A., Pancaldi, G., Papaikonomou, A., Papaleo, R., Păvălas, G. E., Peek, H., Pellegrini, G., Pellegrino, C., Perrina, C., Pfutzner, M., Piattelli, P., Pikounis, K., Pleinert, M. O., Poma, G. E., Popa, V., Pradier, T., Pratolongo, F., Pühlhofer, G., Pulvirenti, S., Quinn, L., Racca, C., Raffaelli, F., Randazzo, N., Rauch, T., Real, D., Resvanis, L., Reubelt, J., Riccobene, G., Rossi, C., Rovelli, A., Saldaña, M., Salvadori, I., Samtleben, D. F. E., Sánchez García, A., Sánchez Losa, A., Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schimmel, F., Schmelling, J., Schnabel, J., Sciacca, V., Sedita, M., Seitz, T., Sgura, I., Simeone, F., Sipala, V., Spisso, B., Spurio, M., Stavropoulos, G., Steijger, J., Stellacci, S. M., Stransky, D., Taiuti, M., Tayalati, Y., Terrasi, Filippo, Tézier, D., Theraube, S., Timmer, P., Tönnis, C., Trasatti, L., Travaglini, R., Trovato, A., Tsirigotis, A., Tzamarias, S., Tzamariudaki, E., Vallage, B., Van Elewyck, V., Vermeulen, J., Versari, F., Vicini, P., Viola, S., Vivolo, D., Volkert, M., Wiggers, L., Wilms, J., de Wolf, E., Zachariadou, K., Zani, S., Zornoza, J. D., Zúñiga, J., Barbarino, Giancarlo, D’Onofrio, A., Garufi, Fabio, Gialanella, L., Hofestädt, J., Marzaioli, F., Orlando, A., Terrasi, F., Vivolo, Daniele, Adrián-Martínez, S., Barrios-Mart, J., Dorosti-Hasankiadeh, Q., Hernández-Rey, J. J., Martínez-Mora, J. A., and Pleinert, M.-O.

Subjects
Astrofísica, Photon, Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, High Tech Systems & Materials, 01 natural sciences, law.invention, High Energy Physics - Experiment, ENERGY, High Energy Physics - Experiment (hep-ex), High Energy Physics - Phenomenology (hep-ph), law, neutrino Telescopes, Charged current, OPT - Optics, Physics, TS - Technical Sciences, Industrial Innovation, SEA, Detector, Instrumentation and Detectors (physics.ins-det), OPTICAL-PROPERTIES, High Energy Physics - Phenomenology, Astronomy--Observations, Neutrino Detectors, Nano Technology, Neutrino, Nuclear and High Energy Physics, TELESCOPE, Cherenkov detector, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Nuclear physics, 0103 physical sciences, lcsh:Nuclear and particle physics. Atomic energy. Radioactivity, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 14. Life underwater, Neutrins, Neutrinos, 010306 general physics, Muon, 010308 nuclear & particles physics, GENERATOR, Neutrino Detectors and Telescopes (experiments), Neutrino astrophysics, KM3NeT, Física::Astronomia i astrofísica [Àrees temàtiques de la UPC], FISICA APLICADA, lcsh:QC770-798, High Energy Physics::Experiment, Electronics, Electron neutrino
Abstract

Studying atmospheric neutrino oscillations in the few-GeV range with a multimegaton detector promises to determine the neutrino mass hierarchy. This is the main science goal pursued by the future KM3NeT/ORCA water Cherenkov detector in the Mediterranean Sea. In this paper, the processes that limit the obtainable resolution in both energy and direction in charged-current neutrino events in the ORCA detector are investigated. These processes include the composition of the hadronic fragmentation products, the subsequent particle propagation and the photon-sampling fraction of the detector. GEANT simulations of neutrino interactions in seawater produced by GENIE are used to study the effects in the 1 - 20 GeV range. It is found that fluctuations in the hadronic cascade in conjunction with the variation of the inelasticity y are most detrimental to the resolutions. The effect of limited photon sampling in the detector is of significantly less importance. These results will therefore also be applicable to similar detectors/media, such as those in ice., 37 pages, 28 figures, JHEP published version

Published
2017

23. Giftig Goud: Kwikvervuiling in Suriname

Author

Aly, S., Bijleveld, B., Buis, J., Edelenbosch, N., van der Meer, T., Rijsdijk, K.F., Institute of Interdisciplinary Studies, and Computational Geo-Ecology (IBED, FNWI)

Abstract

‘Ik zal niet ontkennen dat kwik giftig is; het is gevaarlijk’, aldus Jimmy, een lokale gouddelver in de Brokopondo-provincie. De kleinschalige goudwinning in Suriname brengt grote hoeveelheden kwik in het milieu, met alle gevolgen voor mens en natuur van dien. Constructieve oplossingen - bijvoorbeeld vanuit overheid en mvo - worden niet geboden.

Published
2014

27. Underwater radiance distributions measured with miniaturized multispectral radiance cameras

Author

Antoine, David, Morel, A., Leymarie, E., Houyou, A., Gentili, B., Victori, S., Buis, J., Buis, N., Meunier, S., Canini, M., Crozel, D., Fougnie, B., Henry, P., Antoine, David, Morel, A., Leymarie, E., Houyou, A., Gentili, B., Victori, S., Buis, J., Buis, N., Meunier, S., Canini, M., Crozel, D., Fougnie, B., and Henry, P.

Abstract

Miniaturized radiance cameras measuring underwater multispectral radiances in all directions at high-radiometric accuracy (CE600) are presented. The camera design is described, as well as the main steps of its optical and radiometric characterization and calibration. The results show the excellent optical quality of the specifically designed fish-eye objective. They also show the low noise and excellent linearity of the complementary metal oxide semiconductor (CMOS) detector array that is used. Initial results obtained in various oceanic environments demonstrate the potential of this instrument to provide new measurements of the underwater radiance distribution from the sea surface to dimly lit layers at depth. Excellent agreement is obtained between nadir radiances measured with the camera and commercial radiometers. Comparison of the upwelling radiance distributions measured with the CE600 and those obtained with another radiance camera also shows a very close agreement. The CE600 measurements allow all apparent optical properties (AOPs) to be determined from integration of the radiance distributions and inherent optical properties (IOPs) to be determined from inversion of the AOPs. This possibility represents a significant advance for marine optics by tying all optical properties to the radiometric standard and avoiding the deployment of complex instrument packages to collect AOPs and IOPs simultaneously (except when it comes to partitioning IOPs into their component parts).

Published
2013

30. De factor 20 en de stromenanalyse

Author

Teunissen, A., Buis, J., Canters, K.J., Dijkstra, A.J., and Tjallingii, S.P.

Subjects
Institute for Forestry and Nature Research, Instituut voor Bos- en Natuuronderzoek, Life Science
Published
1999

32. Kortste route zoeken in hybride netwerken: Een routeplanner voor multimodaal goederenvervoer

Author

Buis, J.

Subjects
goederendistributie, wiskundige modellen, planning, goederenvervoer
Abstract

Afstudeerrapport Faculteit der Civiele Techniek, Vakgroep Infrastructuur. Transportweerstanden bestaan vaak uit tijd- en kostenelementen die tijdstipafhankelijk zijn (dienstregelingen, waterhoogten, venstertijden, etc). De vervoerwijzekeuze in het goederentransport is hiervan sterk afhankelijk. In het afstudeerontwerp is een model ontwikkeld om optimale alternatieven te zoeken in het tijd-ruimte-domein van multimodale transportnetwerken. Met dit model is voor de relatie Dortmund-Cambridge onderzocht hoe de water-alternatieven (zeeriviervaart/ kustvaart/binnenvaart) attractiever kunnen worden gemaakt door aanpassing van tijdstipafhankelijke factoren.

Published
1996

33. 'Fata Morgana' - het is niet alleen hout dat er blinkt [Bomen over 2150 ; essay]

Author

Buis, J. and Buis, J.

Abstract

Essay in de categorie 'professionals' uit de wedstrijd "bomen over 2150" die in 2002 werd uitgeschreven door de Stichting Koningsschool. Een uittreksel uit de dagboeken van Jonkheer W. van C. (2105-2193), betrekking hebbend op het beheer van zijn twee landgoederen anno 2150. Houtproductie staat centraal; natuur en recreatie zijn ondergeschikt

Published
2003

35. Evaluation of Thematic Mapper interband registration and noise characteristics

Author

Wrigley, R. C, Hlavka, C. A, Card, D. H, and Buis, J. S

Subjects
Earth Resources And Remote Sensing
Abstract

It is pointed out that the Thematic Mapper (TM) instruments aboard the Landsat-4 and Landsat-5 spacecraft have provided the first digital imagery of the earth's surface with a resolution sufficient to distinguish cultural features easily. The present paper provides a description of the results of studies designed to investigate the band-to-band registration, geodetic registration to a map base, and periodic noise. In the eight TM scenes analyzed, the band-to-band registration accuracy was high even before correction, and the correction for the shift between focal planes brought all bands into registration according to tight specifications.

Published
1985

36. Measurement of Thematic Mapper data quality

Author

Wrigley, R. C, Hlavka, C. A, Card, D. H, Buis, J. S, and Schowengerdt, R. A

Subjects
Earth Resources And Remote Sensing
Abstract

Thematic Mapper data from Landsat-4 and Landsat-5 were examined for band-to-band registration, absolute geodetic registration, periodic noise and spatial resolution. Between focal planes, appreciable misregistrations existed in early data products but were corrected in later data products. The analysis of absolute geodetic registration used only system-corrected data because ground control point-corrected data were unavailable. Geodetic registration errors averaged only 9.7 pixels, less than expected for system-corrected data. Periodic noise at four spatial frequencies was observed in Landsat-5 Thematic Mapper data by using Fourier analysis on small areas over water. Magnitudes of periodic noise components were consistent within a scene. The modulation transfer function was determined for two Landsat-4 scenes. The effective instantaneous field of view was 40.8 meters in one case, and 48.6 meters in the other.

Published
1985

37. Changes in classification accuracy due to varying Thematic Mapper and multispectral scanner spatial, spectral, and radiometric resolution

Author

Acevedo, W, Buis, J. S, and Wrigley, R. C

Subjects
Earth Resources And Remote Sensing
Abstract

The present paper provides the results of a factorial experiment designed to study the classification differences resulting from varying TM and MSS sensor resolution. Eight simulated data sets of various TM and MSS spatial, spectral, and radiometric resolutions were generated on the basis of Daedalus aircraft scanner data. It is pointed out that the current study provides more precise results than previous work, because more exact methods of data simulation with regard to the three factors were emphasized. Two methods of analysis are considered in the paper. To improve on earlier studies, efforts were made to collect an extensive amount of ground reference data. The summaries of classification accuracies for the training sites in the factorial analysis are presented in a table.

Published
1985

38. The effect of spatial, spectral and radiometric factors on classification accuracy using Thematic Mapper data

Author

Wrigley, R. C, Acevedo, W, Alexander, D, Buis, J, and Card, D

Subjects
Earth Resources And Remote Sensing
Abstract

An experiment of a factorial design was conducted to test the effects on classification accuracy of land cover types due to the improved spatial, spectral and radiometric characteristics of the LANDSAT Thematic Mapper (TM) in comparison to the Multispectral Scanner (MSS). High altitude aircraft scanner data from the Airborne Thematic Mapper instrument was used to simulate TM data as well as all combinations of the three characteristics for eight data sets in all. Results for the training sites (field-center pixels) show better classification accuracies for MSS spatial resolution, TM spectral bands and TM radiometry in order of importance.

Published
1984

39. Information content comparison of Thematic Mapper, multispectral scanner and airborne Thematic Mapper data

Author

Buis, J. S, Acevedo, W, Alexander, D. A, and Wrigley, R. C

Subjects
Earth Resources And Remote Sensing
Abstract

It is pointed out that on August 12, 1983 a test of the Tracking and Data Relay Satellite System in conjunction with the operation of Landsat 4 provided both Thematic Mapper (TM) and Multispectral Scanner (MSS) data over Central California. In addition, on August 12, NASA Ames Research Center (ARC) acquired Airborne Thematic Mapper (ATM) data with the high altitude U-2 aircraft. Attention is given to the procedures and results of a study which is currently being conducted at ARC to take full advantage of the data collected on August 12, 1983. Use is made of a series of degradations which should provide a very close approximation of TM and MSS data.

Published
1984

40. A comparative evaluation of simulated SPOT, Thematic Mapper, and simulated Thematic Mapper data in a western ecozone

Author

Buis, J. S

Subjects
Earth Resources And Remote Sensing
Abstract

Spectral information content was quantitatively measured for simulated SPOT, Thematic Mapper, and simulated Thematic Mapper data acquired over Santa Cruz County, California. Two techniques were employed: spectral separability summarized through optimal wave band evaluation, and histogram cluster analysis. Using data from the three sources it is shown that three spectral bands can provide separability nearly as high as six bands provide, if the three bands are optimally chosen for the cover type. Analysis of the Santa Cruz scene emphasizes the importance of TM bands 1 and 5 in particular. The three bands of the SPOT scanner are shown to provide sufficient separability for cover types within the study area. The higher spatial resolution data (20 meters) provided by SPOT contain more distinct distributions than data from the other sources studied. Techniques should be developed to exploit this additional information.

Published
1984

41. The role of spatial, spectral and radiometric resolution on information content

Author

Buis, J. S, Acevedo, W, Wrigley, R. C, and Alexander, D. A

Subjects
Earth Resources And Remote Sensing
Abstract

The results of a factorial experiment to evaluate the effects of spatial, spectral, and radiometric resolution on training-data spectral separability and classification accuracy are reported. Aircraft scanner data from five flightlines at 19.8 km over California including croplands, rangeland, forest, water, and urban areas were systematically degraded over a range approximately from Landsat MSS to Thematic Mapper specifications. Reference data were collected on the ground and from aerial photography. The degradations, training-site delineation, data-analysis procedures, and accuracy-assessment techniques are described; the results are presented in tables and graphs and discussed. It is found that while accuracy was increased by higher spectral resolution in 70 percent of the cases and uniformly by increased radiometric resolution, it was decreased by higher spatial resolution. This phenomenon is attributed to classification methods.

Published
1983

42. Spectral, spatial and radiometric factors in cover type discrimination

Author

Alexander, D, Buis, J, Acevedo, W, and Wrigley, R

Subjects
Earth Resources And Remote Sensing
Abstract

The influence of spatial, spectral, and radiometric resolutions on the utilization of Thematic Mapper (TM) and Multispectral Scanner (MSS) data is assessed quantitatively using a 2 x 2 x 2 factorial design experiment. Eight possible factor combinations were examined for agricultural, urban, forestry, range, and water types of land covers for three levels of information. Spectral bandwidths were configured to simulate all four Landsat MSS channels and Landsat TM channels 1, 2, 3, 4, and 7. By means of bar charts and tables it is shown that the 8-bit radiometric and 75-meter spatial resolutions provide a higher overall accuracy than the 6-bit radiometric and 25-meter spatial resolutions. Spectrally, the difference between the four MSS channels and five TM channel configurations is noted to be insignificant.

Published
1983

47. Metaforen voor de wildernis : eik, hazelaar, rund en paard

Author

Vera, F.W.M., Buis, J., Bottema, S., Miedema, R., Rogaar, H., Vera, F.W.M., Buis, J., Bottema, S., Miedema, R., and Rogaar, H.

Abstract

Dit nummer van het Nederlands Bosbouw Tijdschrift is voornamelijk gewijd aan het proefschrift "Metaforen voor de wildernis : eik, hazelaar, rund en paard," van Frans Vera. Visie van o.a. Miedema en Rogaar, onder de titel "Grasland- en bosbodems...". Vervolgens wordt de reeks artikelen afgesloten met een interview met Vera, waarin hij reageert op de reacties

Published
1998

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