139 results on '"Bugno, Ryszard"'
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2. Unraveling psilocybin’s therapeutic potential: behavioral and neuroplasticity insights in Wistar-Kyoto and Wistar male rat models of treatment-resistant depression
3. Assessing health risks in bottled water: chemical compounds and their impact on human health
4. Effects of ketamine optical isomers, psilocybin, psilocin and norpsilocin on time estimation and cognition in rats
5. Uncovering the unique characteristics of different groups of 5-HT5AR ligands with reference to their interaction with the target protein.
6. Tuning the activity of known drugs via the introduction of halogen atoms, a case study of SERT ligands – Fluoxetine and fluvoxamine
7. Inhibition of PDE5A1 guanosine cyclic monophosphate (cGMP) hydrolysing activity by sildenafil analogues that inhibit cellular cGMP efflux.
8. Rationally designed N-phenylsulfonylindoles as a tool for the analysis of the non-basic 5-HT6R ligands binding mode
9. Virtual screening-driven discovery of dual 5-HT6/5-HT2A receptor ligands with pro-cognitive properties
10. 2-Aminoimidazole-based antagonists of the 5-HT6 receptor – A new concept in aminergic GPCR ligand design
11. Fluorinated indole-imidazole conjugates: Selective orally bioavailable 5-HT7 receptor low-basicity agonists, potential neuropathic painkillers
12. The Differential Influence of PZM21, A Nonrewarding μ-opioid Receptor Agonist With G Protein Bias, on Behavioural Despair and Fear Response in Mice
13. Design and Synthesis of New Quinazolin-4-one Derivatives with Negative mGlu7 Receptor Modulation Activity and Antipsychotic-Like Properties
14. Zinc Deficiency Blunts the Effectiveness of Antidepressants in the Olfactory Bulbectomy Model of Depression in Rats
15. Zinc Deficiency Blunts the Effectiveness of Antidepressants in the Olfactory Bulbectomy Model of Depression in Rats
16. Design and Synthesis of New Quinazolin-4-one Derivatives with Negative mGlu 7 Receptor Modulation Activity and Antipsychotic-Like Properties.
17. Comparison of an Addictive Potential of μ-Opioid Receptor Agonists with G Protein Bias: Behavioral and Molecular Modeling Studies
18. New 1,2,4-oxadiazole derivatives with positive mGlu4 receptor modulation activity and antipsychotic-like properties
19. New 1,2,4-oxadiazole derivatives with positive mGlu4 receptor modulation activity and antipsychotic-like properties.
20. SAR studies on new bis-aryls 5-HT 7 ligands: Synthesis and molecular modeling
21. Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT3 and 5-HT6 Receptor Antagonist with Antipsychotic and Procognitive Properties
22. N-Skatyltryptamines—Dual 5-HT6R/D2R Ligands with Antipsychotic and Procognitive Potential
23. The influence of modifications in imide fragment structure on 5-HT 1A and 5-HT 7 receptor affinity and in vivo pharmacological properties of some new 1-( m-trifluoromethylphenyl)piperazines
24. Low Basicity as a Characteristic for Atypical Ligands of Serotonin Receptor 5-HT2
25. Structure–intrinsic activity relationship studies in the group of 1-imido/amido substituted 4-(4-arylpiperazin-1-yl)cyclohexane derivatives; new, potent 5-HT 1A receptor agents with anxiolytic- like activity
26. Molecular Modeling of µ Opioid Receptor Ligands with Various Functional Properties: PZM21, SR-17018, Morphine, and Fentanyl—Simulated Interaction Patterns Confronted with Experimental Data
27. Functional characterization of a novel opioid, PZM21, and its effects on the behavioural responses to morphine
28. Novel, flexible, and conformationally defined analogs of gepirone: synthesis and 5-HT 1A, 5-HT 2A, and D 2 receptor activity
29. 2-Aminoimidazole-based antagonists of the 5-HT6 receptor - A new concept in aminergic GPCR ligand design
30. Pharmaceuticals and personal care products in the urban groundwater – preliminary monitoring (case study: Kraków, Southern Poland).
31. Serotonin type 5A receptor antagonists inhibit D-lysergic acid diethylamide discriminatory cue in rats
32. Design and synthesis of novel metabotropic glutamate receptor allosteric modulators
33. Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT3and 5-HT6Receptor Antagonist with Antipsychotic and Procognitive Properties
34. Oncotoxic Properties of Serotonin Transporter Inhibitors and 5-HT1A Receptor Ligands
35. Effects of a novel G protein-biased opioid, PZM21, on nociceptive and addiction-like behavior in mice
36. 5-HT1A receptor ligands and their therapeutic applications: review of new patents
37. Synthesis and characterization of novel metabotropic glutamate receptor 2/3 (mGluR2/3) positive allosteric modulator (PAM)
38. Low-basicity 5-HT7 Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol
39. Halogen bonding enhances activity in a series of dual 5-HT6/D2 ligands designed in a hybrid bioisostere generation/virtual screening protocol
40. IP562083 a novel mGluR7 negative allosteric modulator
41. Halogen bonding enhances activity in a series of dual 5-HT6/D2 ligands designed in a hybrid bioisostere generation/virtual screening protocol.
42. IF270750: Synthesis and pharmacology of novel mGluR4 positive allosteric modulator
43. SAR studies on new bis-aryls 5-HT7 ligands: Synthesis and molecular modeling
44. The influence of modifications in imide fragment structure on 5-HT1A and 5-HT7 receptor affinity and in vivo pharmacological properties of some new 1-(m-trifluoromethylphenyl)piperazines
45. Conformational Restriction in Novel NAN-190 and MP3022 Analogs and Their 5-HT1A Receptor Activity
46. Structure–intrinsic activity relationship studies in the group of 1-imido/amido substituted 4-(4-arylpiperazin-1-yl)cyclohexane derivatives; new, potent 5-HT1A receptor agents with anxiolytic- like activity
47. Novel, flexible, and conformationally defined analogs of gepirone: synthesis and 5-HT1A, 5-HT2A, and D2 receptor activity
48. A study on application of impregnated synthetic peptide TLC stationary phases for the screening of 5-HT1A ligands. Part 2
49. New Imide 5-HT1A Receptor Ligands – Modification of Terminal Fragment Geometry
50. Modification of the Structure of 4, 6‐Disubstituted 2‐(4‐Alkyl‐1‐piperazinyl)pyridines: Synthesis and Their 5‐HT2A Receptor Activity
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