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20 results on '"Buffin-Meyer, Benedicte"'

1. Renal and Extrarenal Phenotypes in Patients With HNF1B Variants and Chromosome 17q12 Microdeletions

Author

Ariceta, Gema, Benetti, Elisa, Benz, Marcus R., Bjerre, Anna, Boudailliez, Bernard R., Bouts, Antonia, Drube, Jens, Gjerstad, Ann Christin, Jankauskiene, Augustina, Jávorszky, Eszter, Jay, Nadine, Kirschstein, Martin, Varda, Nataša Marčun, Niel, Olivier, Nobili, François, Pietrement, Christine, Ruzgiene, Dovile, Schild, Raphael, Staude, Hagen, Tory, Kálmán, Tsimaratos, Michel, Walden, Ulrike, Zappel, Hildegard, Buffin-Meyer, Bénédicte, Richard, Juliette, Guigonis, Vincent, Weber, Stefanie, König, Jens, Heidet, Laurence, Moussaoui, Nabila, Vu, Jeanne-Pierrette, Faguer, Stanislas, Casemayou, Audrey, Prakash, Richa, Baudouin, Véronique, Hogan, Julien, Alexandrou, Demi, Bockenhauer, Detlef, Bacchetta, Justine, Ranchin, Bruno, Pruhova, Stepanka, Zieg, Jakub, Lahoche, Annie, Okorn, Christine, Antal-Kónya, Violetta, Morin, Denis, Becherucci, Francesca, Habbig, Sandra, Liebau, Max C., Mauras, Mathilde, Nijenhuis, Tom, Llanas, Brigitte, Mekahli, Djalila, Thumfart, Julia, Tönshoff, Burkhard, Massella, Laura, Eckart, Philippe, Cloarec, Sylvie, Cruz, Alejandro, Patzer, Ludwig, Roussey, Gwenaelle, Vrillon, Isabelle, Dunand, Olivier, Bessenay, Lucie, Taroni, Francesca, Zaniew, Marcin, Louillet, Ferielle, Bergmann, Carsten, Schaefer, Franz, van Eerde, Albertien M., Schanstra, Joost P., and Decramer, Stéphane

Published
2024
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3. Amniotic fluid peptides predict postnatal kidney survival in developmental kidney disease

Author

Allegaert, Karel, Aubard, Yves, Basmaison, Odile, Benevent, Jean-Baptiste, Biquard, Florence, Champion, Gérard, Delbosc, Jean-Marie, Eckart, Philippe, Froute, Marie-Françoise, Gaucherand, Pascal, Groussolles, Marion, Guigonis, Vincent, Hougas, Blandine, Le Bouar, Gwenaelle, Martin, Alain, Martin, Sophie, Maupin-Hyvonnet, Mariannick, Merveille, Marina, Mousty, Eve, Nobili, François, Ryckewaert, Amelie, Sartor, Agnes, Taque, Sophie, Winer, Norbert, Klein, Julie, Buffin-Meyer, Bénédicte, Boizard, Franck, Moussaoui, Nabila, Lescat, Ophélie, Breuil, Benjamin, Fedou, Camille, Feuillet, Guylène, Casemayou, Audrey, Neau, Eric, Hindryckx, An, Decatte, Luc, Levtchenko, Elena, Raaijmakers, Anke, Vayssière, Christophe, Goua, Valérie, Lucas, Charlotte, Perrotin, Franck, Cloarec, Sylvie, Benachi, Alexandra, Manca-Pellissier, Marie-Christine, Delmas, Hélène Laurichesse, Bessenay, Lucie, Le Vaillant, Claudine, Allain-Launay, Emma, Gondry, Jean, Boudailliez, Bernard, Simon, Elisabeth, Prieur, Fabienne, Lavocat, Marie-Pierre, Saliou, Anne-Hélène, De Parscau, Loic, Bidat, Laurent, Noel, Catherine, Floch, Corinne, Bourdat-Michel, Guylène, Favre, Romain, Weingertner, Anne-Sophie, Oury, Jean-François, Baudouin, Véronique, Bory, Jean-Paul, Pietrement, Christine, Fiorenza, Maryse, Massardier, Jérôme, Kessler, Sylvie, Lounis, Nadia, Auriol, Françoise Conte, Marcorelles, Pascale, Collardeau-Frachon, Sophie, Zürbig, Petra, Mischak, Harald, Magalhães, Pedro, Batut, Julie, Blader, Patrick, Saulnier Blache, Jean-Sebastien, Bascands, Jean-Loup, Schaefer, Franz, Decramer, Stéphane, and Schanstra, Joost P.

Published
2021
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5. Mapping of the amniotic fluid proteome of fetuses with congenital anomalies of the kidney and urinary tract identifies plastin 3 as a protein involved in glomerular integrity

Author

Fedou, Camille, Camus, Mylene, Lescat, Ophelie, Feuillet, Guylene, Mueller, Ilka, Ross, Bryony, Buleon, Marie, Neau, Eric, Alves, Melinda, Goudouneche, Dominique, Breuil, Benjamin, Boizard, Franck, Bardou, Quentin, Casemayou, Audrey, Tack, Ivan, Dreux, Sophie, Batut, Julie, Blader, Patrick, Burlet-Schiltz, Odile, Decramer, Stephane, Wirth, Brunhilde, Klein, Julie, Saulnier-Blache, Jean Sebastien, Buffin-Meyer, Benedicte, Schanstra, Joost P., Fedou, Camille, Camus, Mylene, Lescat, Ophelie, Feuillet, Guylene, Mueller, Ilka, Ross, Bryony, Buleon, Marie, Neau, Eric, Alves, Melinda, Goudouneche, Dominique, Breuil, Benjamin, Boizard, Franck, Bardou, Quentin, Casemayou, Audrey, Tack, Ivan, Dreux, Sophie, Batut, Julie, Blader, Patrick, Burlet-Schiltz, Odile, Decramer, Stephane, Wirth, Brunhilde, Klein, Julie, Saulnier-Blache, Jean Sebastien, Buffin-Meyer, Benedicte, and Schanstra, Joost P.

Abstract

Congenital anomalies of the kidney and the urinary tract (CAKUT) are the first cause of chronic kidney disease in childhood. Several genetic and environmental origins are associated with CAKUT, but most pathogenic pathways remain elusive. Considering the amniotic fluid (AF) composition as a proxy for fetal kidney development, we analyzed the AF proteome from non-severe CAKUT (n = 19), severe CAKUT (n = 14), and healthy control (n = 22) fetuses using LC-MS/MS. We identified 471 significant proteins that discriminated the three AF groups with 81% precision. Among them, eight proteins independent of gestational age (CSPG4, LMAN2, ENDOD1, ANGPTL2, PRSS8, NGFR, ROBO4, PLS3) were associated with both the presence and the severity of CAKUT. Among those, five were part of a protein-protein interaction network involving proteins previously identified as being potentially associated with CAKUT. The actin-bundling protein PLS3 (plastin 3) was the only protein displaying a gradually increased AF abundance from control, via non-severe, to severe CAKUT. Immunohistochemistry experiments showed that PLS3 was expressed in the human fetal as well as in both the fetal and the postnatal mouse kidney. In zebrafish embryos, depletion of PLS3 led to a general disruption of embryonic growth including reduced pronephros development. In postnatal Pls3-knockout mice, kidneys were macroscopically normal, but the glomerular ultrastructure showed thickening of the basement membrane and fusion of podocyte foot processes. These structural changes were associated with albuminuria and decreased expression of podocyte markers including Wilms' tumor-1 protein, nephrin, and podocalyxin. In conclusion, we provide the first map of the CAKUT AF proteome that will serve as a reference for future studies. Among the proteins strongly associated with CAKUT, PLS3 did surprisingly not specifically affect nephrogenesis but was found as a new contributor in the maintenance of normal kidney function, at least in p

Published
2021

8. MO441CALPROTECTIN IS A NOVEL CONTRIBUTING FACTOR IN VASCULAR CALCIFICATION AND A PREDICTOR OF CARDIOVASCULAR OUTCOME IN CKD PATIENTS*

Author

Amaya Garrido, Ana, primary, Valdivielso, José M, additional, Faguer, Stanislas, additional, Del Bello, Arnaud, additional, Buffin-Meyer, Benedicte, additional, Piedrafita, Alexis, additional, Camus, Mylene, additional, Schiltz, Odile, additional, Bascands, Jean-Loup, additional, HOBSON, SAM, additional, Kublickiene, Karolina, additional, Stenvinkel, Peter, additional, Schanstra, Joost, additional, and Klein, Julie, additional

Published
2021
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9. The ANTENATAL multicentre study to predict postnatal renal outcome in fetuses with posterior urethral valves: objectives and design

Author

Buffin-Meyer, Benedicte, Klein, Julie, Zanden, L.F.M. van der, Levtchenko, E.N., Moulos, Panogiotis, Lounis, Nadia, Schreuder, M.F., Feitz, W.F.J., Decramer, Stephane, Schanstra, Joost P., Buffin-Meyer, Benedicte, Klein, Julie, Zanden, L.F.M. van der, Levtchenko, E.N., Moulos, Panogiotis, Lounis, Nadia, Schreuder, M.F., Feitz, W.F.J., Decramer, Stephane, and Schanstra, Joost P.

Abstract

Contains fulltext : 226154.pdf (Publisher’s version ) (Open Access)

Published
2020

12. NA-K-ATPase along rat nephron after subtotal nephrectomy: effect of enalapril

Author

Terzi, Fabiola, Cheval, Lydie, Barlet-Bas, Catherine, Younes-Ibrahim, Mauricio, Buffin-Meyer, Benedicte, Burtin, Martine, Beaufils, Helene, Marsy, Sophie, Girolami, Jean-Pierre, Kleinknecht, Claire, and Doucet, Alain

Subjects
Adenosine triphosphatase -- Physiological aspects, Kidney tubules -- Physiological aspects, Nephrectomy -- Physiological aspects, Enalapril -- Health aspects, Biological sciences
Abstract

Sodium-potassium-adenosinetriphosphatase (Na-K-ATPase) activity significantly increases after a 70% renal mass reduction. A marked tubular hypertrophy also occurs within a six week period. A selective prevention of an increase in Na-K-ATPase along the collecting duct occurs on chronic administration of the angiotensin-converting enzyme inhibitor enalapril. A study investigates NA-K-ATPase activity along rat nephron after subtotal nephrectomy and the effect of enalapril on hypertrophy.

Published
1996

14. Additional file 9: of Systems biology combining human- and animal-data miRNA and mRNA data identifies new targets in ureteropelvic junction obstruction

Author

Papadopoulos, Theofilos, Casemayou, Audrey, Neau, Eric, Breuil, Benjamin, CÊcile Caubet, Calise, Denis, Thornhill, Barbara, Bachvarova, Magdalena, Belliere, Julie, Chevalier, Robert, Moulos, Panagiotis, Bachvarov, Dimcho, Buffin-Meyer, Benedicte, StÊphane Decramer, FrançOise Auriol, Jean-Loup Bascands, Schanstra, Joost, and Klein, Julie

Abstract

Sequences of primers used. (DOCX 11Â kb)

Published
2017
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15. Systems biology combining human- and animal-data miRNA and mRNA data identifies new targets in ureteropelvic junction obstruction

Author

Papadopoulos, Theofilos, Casemayou, Audrey, Neau, Eric, Breuil, Benjamin, Caubet, Cécile, Calise, Denis, Thornhill, Barbara A., Bachvarova, Magdalena, Belliere, Julie, Chevalier, Robert L., Moulos, Panagiotis, Bachvarov, Dimcho, Buffin-Meyer, Benedicte, Decramer, Stéphane, Auriol, Françoise Conte, Bascands, Jean-Loup, Schanstra, Joost P., Klein, Julie, BMC, BMC, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Molecular Medicine [Québec], Université Laval [Québec] (ULaval), Department of Pediatrics [Charlottesville, USA], University of Virginia School of Medicine [US], Centre de recherche du CHU de Québec, Medical Biology, Medicine / Université de Laval-Hôtel-Dieu de Québec [Canada]-CHU de Québec–Université Laval, Université Laval [Québec] (ULaval)-Université Laval [Québec] (ULaval), Bioscience [Athens, Greece], HybridStat Predictive Analytics [Athens, Greece], Institute of Molecular Biology and Genetics [Vari, Greece], Biomedical Sciences Research Centre Alexander Fleming [Vari, Greece] (BSRC), Service de Pédiatrie - Néphrologie, Médecine interne, Hypertension, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre de Référence du Sud Ouest des Maladies Rénales Rares, Centre d'investigation clinique de Toulouse (CIC 1436), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Pôle Santé publique et médecine publique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Diabète athérothrombose et thérapies Réunion Océan Indien (DéTROI), Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), This work was supported in part by the 'Clinical and system-omics for the identification of the Molecular Determinants of established Chronic Kidney Disease' (iMODE-CKD, PEOPLE-ITN-GA-2013–608332) project for TP, by the French 'Programme Hospitalier de Recherche Clinique' (PHRC) number N° 06 223 01–N° RCB 2007-A00854-49 for SD and the «Fondation du Rein sous égide de la Fondation pour la Recherche Médicale et ses partenaires », grant number GENZYME 2014 FDR-SdN/FRM for JK., Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, CHU Toulouse [Toulouse]-Hôpital des Enfants, CHU Toulouse [Toulouse], Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de La Réunion (UR)

Subjects
Male, Microarrays, [SDV]Life Sciences [q-bio], urologic and male genital diseases, Cell Line, Pelvis, Mice, let-7a-5p and miR-29b-3p, Structural Biology, Modelling and Simulation, Animals, Humans, Obstructive nephropathy, Molecular Targeted Therapy, RNA, Messenger, Molecular Biology, Applied Mathematics, Gene Expression Profiling, Systems Biology, Infant, Newborn, Infant, [SDV] Life Sciences [q-bio], MicroRNAs, Case-Control Studies, DTX4 and NAV1, miRNAs/microRNAs, Ureteral Obstruction, Research Article
Abstract

Background Although renal fibrosis and inflammation have shown to be involved in the pathophysiology of obstructive nephropathies, molecular mechanisms underlying evolution of these processes remain undetermined. In an attempt towards improved understanding of obstructive nephropathy and improved translatability of the results to clinical practice we have developed a systems biology approach combining omics data of both human and mouse obstructive nephropathy. Results We have studied in parallel the urinary miRNome of infants with ureteropelvic junction obstruction and the kidney tissue miRNome and transcriptome of the corresponding neonatal partial unilateral ureteral obstruction (UUO) mouse model. Several hundreds of miRNAs and mRNAs displayed changed abundance during disease. Combination of miRNAs in both species and associated mRNAs let to the prioritization of five miRNAs and 35 mRNAs associated to disease. In vitro and in vivo validation identified consistent dysregulation of let-7a-5p and miR-29-3p and new potential targets, E3 ubiquitin-protein ligase (DTX4) and neuron navigator 1 (NAV1), potentially involved in fibrotic processes, in obstructive nephropathy in both human and mice that would not be identified otherwise. Conclusions Our study is the first to correlate a mouse model of neonatal partial UUO with human UPJ obstruction in a comprehensive systems biology analysis. Our data revealed let-7a and miR-29b as molecules potentially involved in the development of fibrosis in UPJ obstruction via the control of DTX4 in both man and mice that would not be identified otherwise. Electronic supplementary material The online version of this article (doi:10.1186/s12918-017-0411-7) contains supplementary material, which is available to authorized users.

Published
2016
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16. Systems biology combining human- and animal-data miRNA and mRNA data identifies new targets in ureteropelvic junction obstruction

Author

Papadopoulos, Theofilos, primary, Casemayou, Audrey, additional, Neau, Eric, additional, Breuil, Benjamin, additional, Caubet, Cécile, additional, Calise, Denis, additional, Thornhill, Barbara A., additional, Bachvarova, Magdalena, additional, Belliere, Julie, additional, Chevalier, Robert L., additional, Moulos, Panagiotis, additional, Bachvarov, Dimcho, additional, Buffin-Meyer, Benedicte, additional, Decramer, Stéphane, additional, Auriol, Françoise Conte, additional, Bascands, Jean-Loup, additional, Schanstra, Joost P., additional, and Klein, Julie, additional

Published
2017
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