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3. Contributors

Author

Abzug, Mark J., primary, Adderson, Elisabeth E., additional, Agwu, Allison L., additional, Alby, Kevin, additional, Aldrovandi, Grace M., additional, Allen, Upton D., additional, Alvarez-Hernández, Gerardo, additional, Ampofo, Krow, additional, Anderson, Evan J., additional, Anderson, Margot, additional, Antonara, Stella, additional, Ardura, Monica I., additional, Arguin, Paul M., additional, Arnold, John C., additional, Aronson, Naomi E., additional, Arvin, Ann M., additional, Ashkenazi, Shai, additional, Asturias, Edwin J., additional, Badalyan, Vahe, additional, Baker, Carol J., additional, Balakrishnan, Karthik, additional, Barros, Brittany S., additional, Barson, William J., additional, Bausch, Daniel G., additional, Bechtel, Kirsten, additional, Benjamin, Daniel K., additional, Berman, David M., additional, Blanco, David A., additional, Bloch, Karen C., additional, Blythe, Margaret J., additional, Bocchini, Joseph A., additional, Bowen, Anna, additional, Bowie, William R., additional, Boyce, Thomas G., additional, Bradley, John S., additional, Brady, Michael T., additional, Bratcher, Denise F., additional, Braverman, Paula K., additional, Bresee, Joseph, additional, Brook, Itzhak, additional, Brown, Kevin E., additional, Bryant, Kristina, additional, Buescher, E. Stephen, additional, Burns, Jane L., additional, Byington, Carrie L., additional, Camacho-Gonzalez, Andres F., additional, Cantey, Paul, additional, Carter, Bryan D., additional, Caserta, Mary T., additional, Castagnini, Luis A., additional, Cerini, Chiara, additional, Chadwick, Ellen Gould, additional, Chiang, Silvia S., additional, Christenson, John C., additional, Coffin, Susan E., additional, Collier, Melissa G., additional, Collins, Jennifer P., additional, Conklin, Laurie S., additional, Connelly, Beverly L., additional, Contopoulos-Ioannidis, Despina, additional, Conway, James H., additional, Cortese, Margaret M., additional, Cox, Elaine G., additional, Creech, C. Buddy, additional, Crews, Jonathan D., additional, Cunningham, Dennis J., additional, Curtis, Nigel, additional, Dailey, Natalie J.M., additional, Danziger-Isakov, Lara A., additional, Darville, Toni, additional, Dasch, Gregory A., additional, Daskalaki, Irini, additional, Daum, Robert S., additional, Davenport, Michael, additional, Davies, H. Dele, additional, Dawood, Fatimah S., additional, Day, J. Christopher, additional, de la Morena, Maite, additional, Demmler-Harrison, Gail J., additional, DeMuri, Gregory P., additional, Despommier, Dickson D., additional, Diefenbach, Karen A., additional, Edwards, Kathryn M., additional, Edwards, Morven S., additional, Eichenfield, Lawrence F., additional, Elston, Dirk M., additional, Emerson, Beth, additional, Ephros, Moshe, additional, Erdem, Guliz, additional, Eremeeva, Marina E., additional, Ericson, Jessica E., additional, Esposito, Douglas H., additional, Farley, Monica M., additional, Feingold, Anat R., additional, Feja, Kristina N., additional, Finn, Adam, additional, Fischer, Marc, additional, Flynn, Patricia M., additional, Fox, LeAnne M., additional, Frank, Michael M., additional, Fredrick, Douglas R., additional, Frenck, Robert W., additional, Friedlander, Sheila Fallon, additional, Gans, Hayley A., additional, Gauthier, Gregory M., additional, Gerber, Jeffrey S., additional, Gigliotti, Francis, additional, Gilger, Mark A., additional, Glaser, Carol A., additional, Goddard, Amanda F., additional, Gold, Benjamin D., additional, Gould, Jane M., additional, Green, Michael, additional, Greenberg, David, additional, Greywal, Tanya, additional, Griffin, Daniel, additional, Griffin, Patricia M., additional, Grom, Alexei A., additional, Gutierrez, Kathleen, additional, Gutman, Julie, additional, Guzman-Cottrill, Judith A., additional, Hall, Aron J., additional, Han, Jin-Young, additional, Harper, Marvin B., additional, Harris, Julie R., additional, Harrison, Christopher J., additional, Haslam, David B., additional, Hawkes, Sarah J., additional, Hendley, J. Owen, additional, Henry, Marion C.W., additional, Hilinski, Joseph A., additional, Hills, Susan L., additional, Holmberg, Scott D., additional, Holtzman, Deborah, additional, Hong, David K., additional, Hotez, Peter J., additional, Hsu, Katherine K., additional, Hunstad, David A., additional, Hwang, Loris Y., additional, Jackson, Mary Anne, additional, Jacobs, Richard F., additional, Jhaveri, Ravi, additional, Jirků-Pomajbíková, Kateřina, additional, Jones, Jeffrey L., additional, Karki, Mahima, additional, Karlowicz, M. Gary, additional, Katz, Ben Z., additional, Kaur, Ishminder, additional, Kersh, Gilbert J., additional, Keystone, Jay S., additional, Khan, Muhammad Ali, additional, Kimberlin, David W., additional, Kleiman, Martin B., additional, Klein, Bruce S., additional, Klontz, Karl, additional, Knust, Barbara, additional, Koh, Andrew Y., additional, Korgenski, E. Kent, additional, Krogstad, Paul, additional, Kutty, Preeta Krishnan, additional, Lauren, Christine T., additional, Lawrence, Hillary S., additional, Leber, Amy, additional, Lee, Grace M., additional, Leibovitz, Eugene, additional, Leshem, Eyal, additional, Levasseur, Stéphanie, additional, Lewis, David B., additional, Livingston, Robyn A., additional, Llata, Eloisa, additional, Long, Sarah S., additional, Lopman, Ben A., additional, Lucero, Yalda C., additional, Luján-Zilbermann, Jorge, additional, Luzuriaga, Katherine, additional, MacDonald, Noni E., additional, Maldonado, Yvonne A., additional, Manaloor, John, additional, Mani, Chitra S., additional, Manthiram, Kalpana, additional, Marshall, Gary S., additional, Martin, Stacey W., additional, Matanock, Almea, additional, Matiz, Catalina, additional, Mawle, Alison C., additional, Mazzulli, Tony, additional, McGann, Kathleen A., additional, McIntosh, Kenneth, additional, McNamara, Lucy A., additional, Meir, Michal, additional, Meislich, Debrah, additional, Meissner, H. Cody, additional, Meites, Elissa, additional, Mejías, Asunción, additional, Mertsola, Jussi, additional, Messacar, Kevin, additional, Mhaissen, Mohammed Nael, additional, Michaels, Marian G., additional, Miller, Melissa B., additional, Mintz, Eric D., additional, Modlin, John F., additional, Mohan, Parvathi, additional, Montgomery, Susan P., additional, Montoya, José G., additional, Moro, Pedro L., additional, Moscicki, Anna-Barbara, additional, Moss, R. Lawrence, additional, Myers, Angela L., additional, Nadel, Simon, additional, Neely, Michael N., additional, Neil, Karen P., additional, Nelson, Joanna, additional, Nelson, Noele P., additional, Nicholson, William L., additional, Nizet, Victor, additional, Nopper, Amy Jo, additional, Ochoa, Theresa J., additional, Orenstein, Walter A., additional, O'Ryan, Miguel, additional, Paddock, Christopher D., additional, Pall, Harpreet, additional, Panuganti, Suresh Kumar, additional, Pappas, Diane E., additional, Pass, Robert F., additional, Patterson, Thomas F., additional, Patton, Monica E., additional, Pelton, Stephen I., additional, Petersen, Brett W., additional, Pickering, Larry K., additional, Pinninti, Swetha, additional, Planet, Paul J., additional, Pollard, Andrew J., additional, Posfay-Barbe, Klara M., additional, Poulsen, Casper S., additional, Poutanen, Susan M., additional, Powers, Ann M., additional, Prober, Charles G., additional, Ramilo, Octavio, additional, Rangel, Shawn J., additional, Rao, Suchitra, additional, Rawstron, Sarah A., additional, Read, Jennifer S., additional, Reed, Michael D., additional, Relich, Ryan F., additional, Reller, Megan E., additional, Rellosa, Neil, additional, Rempe, Katherine A., additional, Reyes, Melissa A., additional, Rice-Townsend, Samuel E., additional, Richards, Frank O., additional, Romero, José R., additional, Rosen, David A., additional, Rostad, Christina A., additional, Rours, G. Ingrid J.G., additional, Routh, Janell A., additional, Rowley, Anne H., additional, Rubin, Lorry G., additional, Ryan, Edward T., additional, Saiman, Lisa, additional, Sammons, Julia S., additional, Sass, Laura, additional, Sauberan, Jason B., additional, Schillie, Sarah, additional, Schulert, Grant S., additional, Schuster, Jennifer E., additional, Schwartz, Kevin L., additional, Sederdahl, Bethany K., additional, Serpa, Jose A., additional, Shah, Kara N., additional, Shah, Samir S., additional, Shane, Andi L., additional, Shapiro, Eugene D., additional, Shaw, Jana, additional, Shetty, Avinash K., additional, Dairiki, Linda M., additional, Siberry, George Kelly, additional, Siegel, Jane D., additional, Siegel, Robert David, additional, Simonsen, Kari A., additional, Singh, Nalini, additional, Singh, Upinder, additional, Smith, P. Brian, additional, Snyder, John D., additional, Song, Eunkyung, additional, Sorrell, Jennifer L., additional, Souder, Emily, additional, St. Geme, Joseph W., additional, Staat, Mary Allen, additional, Staples, J. Erin, additional, Starke, Jeffrey R., additional, Steinbach, William J., additional, Stensvold, Christen R., additional, Stoner, Bradley P., additional, Strikas, Raymond A., additional, Strober, Jonathan B., additional, Sue, Paul K., additional, Sutton, Deanna A., additional, Swanson, Douglas, additional, Tate, Jacqueline E., additional, Tebruegge, Marc, additional, Teshale, Eyasu H., additional, Thompson, Amelia B., additional, Thompson, George R., additional, Thompson-Stone, Robert, additional, Thomson, Richard B., additional, Thorell, Emily A., additional, Tobin, Nicole H., additional, Toltzis, Philip, additional, Treat, James, additional, Troy, Stephanie B., additional, Van, Russell B., additional, Vaz, Louise Elaine, additional, Vodzak, Jennifer, additional, Wald, Ellen R., additional, Wallihan, Rebecca, additional, Wangu, Zoon, additional, Washam, Matthew, additional, Watson, Joshua R., additional, Wattier, Rachel L., additional, Weinberg, Geoffrey A., additional, White, A. Clinton, additional, Wiesenfeld, Harold C., additional, Williams, John V., additional, Willoughby, Rodney E., additional, Wingerter, Sarah L., additional, Wittler, Robert R., additional, Wong, Karen K., additional, Workowski, Kimberly A., additional, Wright, Terry W., additional, Yagupsky, Pablo, additional, Yen, Catherine, additional, Yi, Jumi, additional, Yoder, Jonathan S., additional, Young, Edward J., additional, Zaenglein, Andrea L., additional, and Zimmerman, Kanecia, additional

Published
2018
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10. Contributors

Author

Adderson, Elisabeth E., primary, Agarwal, Aarti, additional, Aldrovandi, Grace M., additional, Allen, Upton D., additional, Amieva, Manuel R., additional, Ampofo, Krow, additional, Anderson, Alicia D., additional, Anderson, Margot, additional, Arguin, Paul M., additional, Arnold, John C., additional, Arvin, Ann M., additional, Ashkenazi, Shai, additional, Baker, Carol J., additional, Barson, William J., additional, Bausch, Daniel G., additional, Bechtel, Kirsten, additional, Benjamin, Daniel K., additional, Berkowitz, Frank E., additional, Blythe, Margaret J., additional, Bocchini, Joseph A., additional, Boeckh, Michael, additional, Bowen, Anna, additional, Bowie, William R., additional, Boyce, Thomas G., additional, Bradley, John S., additional, Brady, Michael T., additional, Bratcher, Denise F., additional, Braverman, Paula K., additional, Hall, Caroline Breese, additional, Bresee, Joseph S., additional, Brook, Itzhak, additional, Bryant, Kristina, additional, Buescher, E. Stephen, additional, Burns, Jane L., additional, Burstein, Gale R., additional, Byington, Carrie L., additional, Byrd, Kathy K., additional, Cappello, Michael, additional, Carter, Bryan D., additional, Cartwright, Emily J., additional, Caserta, Mary T., additional, Cerini, Chiara, additional, Chadwick, Ellen Gould, additional, Cheesebrough, Beth, additional, Chesney, P. Joan, additional, Christenson, John C., additional, Cleary, Thomas G., additional, Coffin, Susan E., additional, Conklin, Laura M., additional, Conklin, Laurie S., additional, Connelly, Beverly L., additional, Contopoulos-Ioannidis, Despina, additional, Conway, James H., additional, Cortese, Margaret M., additional, Cotten, C. Michael, additional, Cox, Elaine, additional, Crockett, Maryanne E., additional, Crowe, James E., additional, Curtis, Nigel, additional, Cunningham, Dennis J., additional, Shortliffe, Linda Marie Dairiki, additional, Darville, Toni, additional, Dasch, Gregory A., additional, Daskalaki, Irini, additional, Daum, Robert S., additional, Dawood, Fatimah S., additional, Demmler, Gail J., additional, Despommier, Dickson D., additional, Diefenbach, Karen A., additional, Dvorak, Christopher C., additional, Edwards, Kathryn M., additional, Edwards, Morven S., additional, Eichenfield, Lawrence F., additional, Elston, Dirk M., additional, Englund, Janet A., additional, Erard, Veronique, additional, Eremeeva, Marina E., additional, Feingold, Anat R., additional, Finn, Adam, additional, Fiore, Anthony E., additional, Fischer, Marc, additional, Fitch, Sarah J., additional, Flynn, Patricia M., additional, Fox, LeAnne M., additional, Frank, Michael M., additional, Fredrick, Douglas R., additional, Friedlander, Sheila Fallon, additional, Gans, Hayley A., additional, Garcia, Carla G., additional, Garzon, Maria C., additional, Gerber, Jeffrey S., additional, Geschwind, Michael D., additional, Gieraltowski, Laura B., additional, Gigliotti, Francis, additional, Gilligan, Peter H., additional, Glaser, Carol, additional, Gold, Benjamin D., additional, Goldstein, Brahm, additional, Gould, Jane M., additional, Green, Michael, additional, Greenberg, David, additional, Griffin, Patricia M., additional, Grom, Alexei A., additional, Gutierrez, Kathleen, additional, Guzman-Cottrill, Judith A., additional, Hall, Aron J., additional, Harper, Marvin B., additional, Harrison, Christopher J., additional, Haslam, David B., additional, Hawkes, Sarah J., additional, Hayes, Edward B., additional, Hazra, Rohan, additional, Heilig, Sara Jane, additional, Hendley, J. Owen, additional, Henry, Marion C.W., additional, Hilinski, Joseph A., additional, Holmberg, Scott D., additional, Holtzman, Deborah, additional, Hotez, Peter J., additional, Hsu, Katherine K., additional, Hu, Dale J., additional, Hwang, Loris Y., additional, Hyun, David Y., additional, Jackson, Mary Anne, additional, Jacobs, Richard F., additional, Jones, Jeffrey L., additional, Kamili, Saleem, additional, Karlowicz, M. Gary, additional, Katz, Ben Z., additional, Kersh, Gilbert J., additional, Kester, Laura M., additional, Keystone, Jay S., additional, Kimberlin, David W., additional, Kleiman, Martin B., additional, Kline, Mark W., additional, Koh, Andrew Y., additional, Konstantopoulos, Andreas, additional, Koranyi, Katalin I., additional, Korgenski, E. Kent, additional, Kroger, Andrew T., additional, Krogstad, Paul, additional, Lauren, Christine T., additional, Lawrence, Hillary S., additional, Leibovitz, Eugene, additional, Levasseur, Stéphanie, additional, Lewis, David B., additional, Lieberman, Jay M., additional, Liu, Jen-Jane, additional, Livingston, Robyn A., additional, Llata, Eloisa, additional, Loharikar, Anagha R., additional, Long, Sarah S., additional, Lopman, Ben A., additional, Lorber, Bennett, additional, Low, Donald E., additional, Lucero, Yalda C., additional, Luján-Zilbermann, Jorge, additional, Luzuriaga, Katherine, additional, MacDonald, Noni E., additional, MacNeil, Adam, additional, Maldonado, Yvonne A., additional, Mani, Chitra S., additional, Marcon, Mario J., additional, Marshall, Gary S., additional, Martin, Stacey W., additional, Matiz, Catalina, additional, Mawle, Alison C., additional, Mazzulli, Tony, additional, McCracken, George H., additional, McDonald, Matthew B., additional, McGregor, Robert S., additional, McIntosh, Kenneth, additional, McMorrow, Meredith, additional, McNeil, Candice, additional, McQuiston, Jennifer H., additional, Meislich, Debrah, additional, Meissner, H. Cody, additional, Mejías, Asunción, additional, Menon, Manoj P., additional, Mertsola, Jussi, additional, Michaels, Marian G., additional, Miller, Melissa B., additional, Mintz, Eric D., additional, Modlin, John F., additional, Mohan, Parvathi, additional, Montgomery, Susan P., additional, Montoya, Jose G., additional, Moore, Zack S., additional, de la Morena, Maite, additional, Moro, Pedro L., additional, Moscicki, Anna-Barbara, additional, Moss, R. Lawrence, additional, Murphy, Trudy V., additional, Murray, Dennis L., additional, Myers, Angela L., additional, Nadel, Simon, additional, Nataro, James P., additional, Neely, Michael N., additional, Nicholson, William L., additional, Nizet, Victor, additional, Nopper, Amy Jo, additional, Norrby-Teglund, Anna, additional, Ochoa, Theresa J., additional, O’Ryan, Miguel, additional, Orenstein, Walter A., additional, Paddock, Christopher D., additional, Pappas, Diane E., additional, Pass, Robert F., additional, Patterson, Thomas F., additional, Pelton, Stephen I., additional, Pickering, Larry K., additional, Piggott, Caroline Diane Sarah, additional, Pizzo, Philip A., additional, Pollard, Andrew J., additional, Posfay-Barbe, Klara M., additional, Poutanen, Susan M., additional, Powell, Dwight A., additional, Prince, Alice S., additional, Prober, Charles G., additional, Ramilo, Octavio, additional, Rangel, Shawn J., additional, Rawstron, Sarah A., additional, Read, Jennifer S., additional, Reed, Michael D., additional, Regan, Joanna J., additional, Reller, Megan E., additional, Reyes, Melissa A., additional, Rice, Peter A., additional, Rice-Townsend, Samuel E., additional, Richards, Frank O., additional, Rodgers, Gail L., additional, Rollin, Pierre E., additional, Romero, José R., additional, Rours, G. Ingrid J.G., additional, Rowley, Anne H., additional, Roy, Sharon L., additional, Rubin, Lorry G., additional, Ruiz-Palacios, Guillermo M., additional, Saiman, Lisa, additional, Sass, Laura, additional, Sauberan, Jason B., additional, Schantz, Peter M., additional, Schneider, Eileen, additional, Schutze, Gordon E., additional, Schwartz, Benjamin, additional, Schwarzwald, Heidi, additional, Shah, Kara N., additional, Shah, Samir S., additional, Shane, Andi L., additional, Shapiro, Craig A., additional, Shapiro, Eugene D., additional, Sharapov, Umid M., additional, Shaw, Jana, additional, Siberry, George Kelly, additional, Siegel, Jane D., additional, Siegel, Robert David, additional, Singh, Nalini, additional, Singh, Upinder, additional, Smith, P. Brian, additional, Snyder, John D., additional, Soper, David E., additional, Staat, Mary Allen, additional, Staples, J. Erin, additional, Starke, Jeffrey R., additional, Steinbach, William J., additional, Stephens, Ina, additional, St. Geme, Joseph W., additional, Stoner, Bradley P., additional, Strober, Jonathan B., additional, Subbarao, Kanta, additional, Sutton, Deanna A., additional, Swanson, Douglas, additional, Takada, Leonel T., additional, Tate, Jacqueline E., additional, Tauxe, Robert V., additional, Tebruegge, Marc, additional, Teshale, Eyasu H., additional, Thompson, George R., additional, Thompson, Herbert A., additional, Thomson, Richard B., additional, Thorell, Emily A., additional, Tohme, Rania A., additional, Tolan, Robert W., additional, Toltzis, Philip, additional, Treat, James, additional, Troy, Stephanie B., additional, Van Dyke, Russell B., additional, Velarde, Jorge J., additional, Vodzak, Jennifer, additional, Wald, Ellen R., additional, Weinberg, Geoffrey A., additional, White, A. Clinton, additional, Widdowson, Marc-Alain, additional, Wiesenfeld, Harold C., additional, Williams, John V., additional, Williams, Roxanne E., additional, Willoughby, Rodney E., additional, Wilson, Craig M., additional, Wingerter, Sarah L., additional, Winkelstein, Jerry A., additional, Workowski, Kimberly A., additional, Wright, Terry W., additional, Yagupsky, Pablo, additional, Yazigi, Nada, additional, Yen, Catherine, additional, Young, Edward J., additional, Zaenglein, Andrea L., additional, and Zaoutis, Theoklis E., additional

Published
2012
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11. Submicrosecond intense pulsed electric field effects on intracellular free calcium: mechanisms and effects

Author

Buescher, E. Stephen, Smith, Rachel R., and Schoenbach, Karl H.

Subjects
Neutrophils -- Research, Business, Chemistry, Electronics, Electronics and electrical industries
Abstract

Application of submicrosecond intense pulsed electric fields (sm/i-PEF) to cells results in rapid, transient rises in intracellular free calcium concentrations ([[[Ca.sup.++]].sub.i]) in human blood neutrophils, human promyelocytic leukemia cells (HL60), and human T-cell leukemia cells (Jurkat cells). The magnitude of the rise in [[[Ca.sup.++]].sub.i] in human neutrophils is related to the intensity of applied sm/i-PEF. Some 10-50% of the rise in [[[Ca.sup.++]].sub.i] triggered by 300-ns pulses is due to release of [[Ca.sup.++]] from intracellular sources, while maximally 10% of the rise in [[[Ca.sup.++]].sub.i] triggered by 60-ns pulses is due to release from intracellular sources. Repetition of a sm/i-PEF application of lesser intensity than the first pulse fails to induce a rise in [[[Ca.sup.++]].sub.i], while a second pulse of equal or greater intensity elicits a small or moderate rise, respectively. When sm/i-PEF applications were examined for effects on cellular function, no effect was observed on neutrophil phagocytosis. Suppression of spontaneous H202 production was observed after a 300-ns, 60-kV/cm pulse, and transient suppression of neutrophil chemotaxis was observed following a 300-ns and 60-ns, 60-kV/cm pulse. No evidence of proton influx/efflux was found following sm/i-PEF application, sm/i-PEF applications may allow manipulation of selected cell behaviors/function based on their ability to initiate changes in [[[Ca.sup.++]].sub.i]. Index Terms--Intense pulsed electric field, intracellular calcium, submicrosecond.

Published
2004

13. Contributors

Author

Abramson, Jon S., primary, Abzug, Mark J., additional, Aiken, John J., additional, A-kader, H. Hesham, additional, Akdis, Cezmi A., additional, Alderman, Harold, additional, Alemzadeh, Ramin, additional, Alessandrini, Evaline A., additional, Ali, Omar, additional, Ambalavanan, Namasivayam, additional, Anderson, Karl E., additional, Anderson, Peter M., additional, Anthony, Kelly K., additional, Antoon, Alia Y., additional, Ardoin, Stacy P., additional, Arndt, Carola A.S., additional, Arnon, Stephen S., additional, Aronoff, Stephen C., additional, Asher, David M., additional, Asselin, Barbara L., additional, Ater, Joann L., additional, Atkins, Dan, additional, Augustine, Erika F., additional, Augustyn, Marilyn, additional, Avner, Ellis D., additional, Azimi, Parvin H., additional, Bacino, Carlos A., additional, Baldassano, Robert N., additional, Bales, Christina, additional, Balistreri, William F., additional, Baltimore, Robert S., additional, Balwani, Manisha, additional, Baqar, Shahida, additional, Barron, Christine E., additional, Bass, Dorsey M., additional, Batshaw, Mark L., additional, Behrman, Richard E., additional, Bell, Michael J., additional, Belmont, John W., additional, Benjamin, Daniel K., additional, Bennett, Michael J., additional, Bernstein, Daniel, additional, Bhatia, Jatinder, additional, Bhutta, Zulfiqar Ahmed, additional, Biesecker, Leslie G., additional, Birmingham, James, additional, Blanchard, Samra S., additional, Blanton, Ronald, additional, Bleyer, Archie, additional, Boamah, C.D.R. Lynelle M., additional, Boas, Steven R., additional, Boat, Thomas F., additional, Bockting, Walter, additional, Boguniewicz, Mark, additional, Bonthius, Daniel J., additional, Boxer, Laurence A., additional, Brandow, Amanda M., additional, Branski, David, additional, Breault, David T., additional, Buckley, Rebecca H., additional, Budek, Cynthia Etzler, additional, Buescher, E. Stephen, additional, Burstein, Gale R., additional, Bustinduy, Amaya Lopez, additional, Cairo, Mitchell S., additional, Camitta, Bruce M., additional, Campbell, Angela Jean Peck, additional, Carey, Rebecca G., additional, Carlo, Waldemar A., additional, Carrigan, Robert B., additional, Caserta, Mary T., additional, Chadwick, Ellen Gould, additional, Chamberlain, Lisa J., additional, Chapman, Jennifer I., additional, Cheifetz, Ira M., additional, Chemaitilly, Wassim, additional, Chen, Sharon F., additional, Chen, Yuan-Tsong, additional, Chesney, Russell W., additional, Chiriboga, Jennifer A., additional, Christensen, Robert D., additional, Chu, Andrew, additional, Chusid, Michael J., additional, Cieslak, Theodore J., additional, Clark, Jeff A., additional, Cleary, Thomas G., additional, Clemens, John David, additional, Cohen, Joanna S., additional, Cohen, Mitchell B., additional, Cohen, Pinchas, additional, Cohen-Wolkowiez, Michael, additional, Colbert, Robert A., additional, Cole, F. Sessions, additional, Cole, Joanna C.M., additional, Colombo, John L., additional, Cooper, Amber R., additional, Covar, Ronina A., additional, Cromer, Barbara, additional, Crowe, James E., additional, Cunningham, Natoshia Raishevich, additional, Czinn, Steven J., additional, Darville, Toni, additional, Daum, Robert S., additional, Davidson, Richard S., additional, Davies, H. Dele, additional, Dayan, Peter S., additional, DeBaun, Michael R., additional, Degaffe, Guenet H., additional, DeMaso, David R., additional, Denison, Mark R., additional, Dent, Arlene E., additional, DeSilva, Nirupama K., additional, Desnick, Robert J., additional, deVeber, Gabrielle, additional, DeWitt, Esi Morgan, additional, Dhamne, Chetan Anil, additional, Dhawan, Anil, additional, Dietz, Harry, additional, Donoghue, Lydia J., additional, Donohoue, Patricia A., additional, Donovan, Mary K., additional, Dormans, John P., additional, Doyle, Daniel A., additional, Doyle, Jefferson, additional, Dreskin, Stephen C., additional, Drummond, Denis S., additional, Dubowitz, Howard, additional, Dumler, J. Stephen, additional, Duncan, Janet, additional, Duncan, Paula M., additional, Dyner, LauraLe, additional, Earing, Michael G., additional, Edgerton, Elizabeth A., additional, Egan, Marie, additional, Elder, Jack S., additional, Eleoff, Sara B., additional, Elfenbein, Dianne S., additional, Eppes, Stephen C., additional, Ewald, Michele Burns, additional, Fairley, Jessica K., additional, Feigelman, Susan, additional, Felice, Marianne E., additional, Felner, Eric I., additional, Fels, Edward, additional, Ferkol, Thomas, additional, Finder, Jonathan D., additional, Fiorino, Kristin N., additional, Fleece, David M., additional, Flynn, Patricia M., additional, Forman, Joel A., additional, Frank, Michael M., additional, Freedman, Melvin H., additional, Frei-Jones, Melissa, additional, Friedman, Jared E., additional, Gahagan, Sheila, additional, Gardiner, Paula, additional, Garibaldi, Luigi, additional, Gauthier, Gregory M., additional, Gedalia, Abraham, additional, Gelmini, Matthew J., additional, Gerber, Michael A., additional, Gibson, K. Michael, additional, Gibson, Mark, additional, Gigliotti, Francis, additional, Gilliam, Walter S., additional, Gilsdorf, Janet R., additional, Ginsburg, Charles M., additional, Glascoe, Frances P., additional, Goldmann, Donald A., additional, Goodman, Denise M., additional, Gorelick, Marc H., additional, Gosselin, Gary J., additional, Gould, Jane M., additional, Goulet, Olivier, additional, Granoff, Dan M., additional, Green, Michael, additional, Green, Thomas P., additional, Greenbaum, Larry A., additional, Grino, Marie Michelle, additional, Grossman, Andrew B., additional, Grossman, David C., additional, Guarino, Alfredo, additional, Hackney, Lisa R., additional, Haddad, Gabriel G., additional, Haddad, Joseph, additional, Hagan, Joseph F., additional, Halstead, Scott B., additional, Hammerschlag, Margaret R., additional, Hamvas, Aaron, additional, Harris, James C., additional, Hartman, Mary E., additional, Haslam, David B., additional, Hauck, Fern R., additional, Hayden, Gregory F., additional, Hecht, Jacqueline T., additional, Heidemann, Sabrina M., additional, Hendley, J. Owen, additional, Henretig, Fred M., additional, Heresi, Gloria P., additional, Hershey, Andrew D., additional, Herzog, Cynthia E., additional, Hochberg, Jessica, additional, Holinger, Lauren D., additional, Hord, Jeffrey D., additional, Horn, B. David, additional, Horton, William A., additional, Hosalkar, Harish S., additional, Hosono, Hidekazu, additional, Hotez, Peter J., additional, Howenstine, Michelle S., additional, Huddleston, Heather G., additional, Huff, Vicki, additional, Hug, Denise, additional, Huh, Winston W., additional, Hunt, Carl E., additional, Hunter, Anna Klaudia, additional, Ibeziako, Patricia, additional, Jacobs, Richard F., additional, Jensen, Peter, additional, Jenson, Hal B., additional, John, Chandy C., additional, Johnston, Michael V., additional, Johnston, Richard B., additional, Jones, Bridgette L., additional, Jones, James F., additional, Joselow, Marsha, additional, Kalaskar, Anupama, additional, Kaljee, Linda, additional, Kamat, Deepak, additional, Kansra, Alvina R., additional, Kaplan, Sheldon L., additional, Katz, Emily R., additional, Kazura, James W., additional, Keane, Virginia, additional, Kearns, Gregory L., additional, Kelly, Desmond P., additional, Kelsen, Judith, additional, Kemper, Kathi J., additional, Kennedy, Melissa, additional, Kerem, Eitan, additional, Kerschner, Joseph E., additional, Khan, Seema, additional, Kim, Young-Jee, additional, King, Charles H., additional, Kinsman, Stephen L., additional, Kirton, Adam, additional, Kishnani, Priya S., additional, Kizer, Nora T., additional, Kleiman, Martin B., additional, Klein, Bruce L., additional, Klein, Bruce S., additional, Klein, Michael D., additional, Kliegman, Robert M., additional, Koch, William C., additional, Kochanek, Patrick M., additional, Kodish, Eric, additional, Kohlhoff, Stephan A., additional, Krane, Elliot J., additional, Krause, Peter J., additional, Kreipe, Richard E., additional, Krug, Steven E., additional, Kuttesch, John F., additional, Kwon, Jennifer M., additional, Lachenauer, Catherine S., additional, Ladisch, Stephan, additional, LaFranchi, Stephen, additional, Lakser, Oren, additional, Lande, Marc B., additional, Landrigan, Philip J., additional, Landry, Gregory L., additional, Lane, Wendy G., additional, LaRussa, Philip S., additional, Lee, Brendan, additional, Lee, Chul, additional, Lee, K. Jane, additional, Leeder, J. Steven, additional, Lehman, Rebecca K., additional, Lentze, Michael J., additional, Lerner, Norma B., additional, Lestrud, Steven, additional, Leung, Donald Y.M., additional, Liacouras, Chris A., additional, Liewer, Susanne, additional, Liu, Andrew H., additional, Lo, Stanley F., additional, Locatelli, Franco, additional, Long, Sarah S., additional, Lopez, Anna Lena, additional, Lossef, Steven V., additional, Lowry, Jennifer A., additional, Lucco, Kerith, additional, Lyon, G. Reid, additional, Mahajan, Prashant V., additional, Maheshwari, Akhil, additional, Majzoub, Joseph A., additional, Maqbool, Asim, additional, Maranich, Ashley M., additional, Marin, Mona, additional, Marini, Joan C., additional, Markowitz, Morri, additional, Marks, Kevin P., additional, Maroushek, Stacene R., additional, Mason, Wilbert H., additional, Mastropietro, Christopher, additional, Matalon, Kimberlee M., additional, Matalon, Reuben K., additional, Mazor, Robert, additional, McColley, Susanna A., additional, McGovern, Margaret M., additional, McLean, Heather S., additional, McLeod, Rima, additional, Melby, Peter C., additional, Melvin, Joseph John, additional, Merritt, Diane F., additional, Mezoff, Ethan A., additional, Michaels, Marian G., additional, Miethke, Alexander G., additional, Mikati, Mohamad A., additional, Milgrom, Henry, additional, Miller, E. Kathryn, additional, Mink, Jonathan W., additional, Mitchell, Grant A., additional, Montgomery, Robert R., additional, Morelli, Joseph G., additional, Moscicki, Anna-Barbara, additional, Moser, Hugo W., additional, Moyer, Kathryn D., additional, Murphy, James R., additional, Murphy, Timothy F., additional, Murray, Thomas S., additional, Natale, Mindo J., additional, Neal, William A., additional, Ness, Jayne, additional, Neville, Kathleen A., additional, Nevin, Mary A., additional, Newburger, Jane W., additional, Newburger, Peter E., additional, Nield, Linda S., additional, Noah, Zehava, additional, Nogee, Lawrence M., additional, Norris, Robert L., additional, Obaro, Stephen K., additional, Obeid, Makram, additional, Ochoa, Theresa J., additional, O'Donnell, Katherine A., additional, Ohls, Robin K., additional, Okwo-Bele, Jean-Marie, additional, Oldham, Keith T., additional, Olitsky, Scott E., additional, Olsson, John, additional, Orenstein, Susan R., additional, Orenstein, Walter A., additional, Owens, Judith A., additional, Packman, Charles H., additional, Painter, Michael J., additional, Pais, Priya, additional, Pan, Cynthia G., additional, Pannikar, Vijay, additional, Pappas, Diane E., additional, Parish, Anjali, additional, Parks, John S., additional, Parks, Laura A., additional, Patterson, Maria Jevitz, additional, Patwari, Pallavi P., additional, Peters, Timothy R., additional, Pickering, Larry K., additional, Pless, Misha L., additional, Plummer, Laura S., additional, Porter, Craig C., additional, Powell, Dwight A., additional, Price, David T., additional, Prober, Charles G., additional, Quan, Linda, additional, Quint, Elisabeth H., additional, Rabinovich, C. Egla, additional, Raffini, Leslie J., additional, Ramirez-Montealegre, Denia, additional, Raviola, Giuseppe, additional, Reed, Ann M., additional, Rekate, Harold L., additional, Reller, Megan E., additional, Remafedi, Gary, additional, Reyes, Jorge D., additional, Rezvani, Geoffrey, additional, Rezvani, Iraj, additional, Ritchey, A. Kim, additional, Rivara, Frederick P., additional, Robinson, Angela Byun, additional, Rogg, Luise E., additional, Roosevelt, Genie E., additional, Rosenberg, David R., additional, Rosenberg, Melissa Beth, additional, Rosenblatt, David S., additional, Roskind, Cindy Ganis, additional, Rotar, Mary M., additional, Rozenfeld, Ranna A., additional, Rush, Sarah Zieber, additional, Ryan, Colleen A., additional, Sachdev, H.P.S., additional, Sachdeva, Ramesh C., additional, Sahin, Mustafa, additional, Salata, Robert A., additional, Salerno, Denise A., additional, Salvana, Edsel Maurice T., additional, Sampson, Hugh A., additional, Sandora, Thomas J., additional, Sandritter, Tracy, additional, Sankar, Wudbhav N., additional, Sarnaik, Ajit Ashok, additional, Sarnaik, Ashok P., additional, Sarnat, Harvey B., additional, Sarwal, Minnie M., additional, Saunders, Mary, additional, Schanberg, Laura E., additional, Schleiss, Mark R., additional, Schor, Nina F., additional, Schroeder, Bill J., additional, Schum, Robert L., additional, Schutze, Gordon E., additional, Scott, Daryl A., additional, Scott, J. Paul, additional, Sectish, Theodore C., additional, Segel, George B., additional, Sehgal, Kriti, additional, Seidman, Ernest G., additional, Serwint, Janet R., additional, Shah, Dheeraj, additional, Shamir, Raanan, additional, Shapiro, Bruce K., additional, Shaw, Richard J., additional, Shaywitz, Bennett A., additional, Shaywitz, Sally E., additional, Shekar, Meera, additional, Shephard, Elena, additional, Sherman, Philip M., additional, Shneider, Benjamin L., additional, Sicherer, Scott H., additional, Sills, Richard, additional, Simms, Mark D., additional, Simões, Eric A.F., additional, Slovis, Thomas L., additional, Smith, P. Brian, additional, Son, Mary Beth F., additional, Sosinsky, Laura Stout, additional, Spahn, Joseph D., additional, Sperling, Mark A., additional, Spicer, Robert, additional, Spiegel, David A., additional, Spoudeas, Helen, additional, Spranger, Jürgen, additional, Sreedharan, Rajasree, additional, Sreedharan, Raman, additional, Stafford, Shawn J., additional, Stager, Margaret M., additional, Stagno, Sergio, additional, Stallings, Virginia A., additional, Stanberry, Lawrence R., additional, Stanley, Charles A., additional, Stanton, Bonita F., additional, Starke, Jeffrey R., additional, Stass-Isern, Merrill, additional, Stechenberg, Barbara W., additional, Stein, Leonard D., additional, Steinbach, William J., additional, Stettler, Nicolas, additional, Stoll, Barbara J., additional, Storch, Gregory A., additional, Strauss, Ronald G., additional, Suchy, Frederick J., additional, Summar, Karen, additional, Szilagyi, Moira, additional, Tinanoff, Norman, additional, Todd, James K., additional, Tompkins, Lucy S., additional, Tower, Richard L., additional, Troncone, Riccardo, additional, Trott, Amanda A., additional, Tubergen, David G., additional, Turner, David A., additional, Turner, Ronald B., additional, Ullrich, Christina, additional, Van Hare, George F., additional, van Ingen, Jakko, additional, Van Mater, Heather A., additional, van Soolingen, Dick, additional, Van Why, Scott K., additional, Vandana, Pankhuree, additional, Vanderbilt, Douglas, additional, Vanderhoof, Jon A., additional, Velardi, Andrea, additional, Vichinsky, Elliott, additional, Waggoner-Fountain, Linda A., additional, Waguespack, Steven G., additional, Walker, David M., additional, Walter, Heather J., additional, Ware, Stephanie, additional, Watts, Kimberly Danieli, additional, Waxman, Ian M., additional, Weese-Mayer, Debra E., additional, Weise, Kathryn, additional, Weisse, Martin E., additional, Wells, Lawrence, additional, Wen, Jessica, additional, Werlin, Steven L., additional, Wessels, Michael R., additional, Wetmore, Ralph F., additional, Wetzel, Randall C., additional, Wexler, Isaiah D., additional, White, Perrin C., additional, Williams, John V., additional, Willoughby, Rodney E., additional, Wilson, Samantha L., additional, Winnie, Glenna B., additional, Wise, Paul H., additional, Woc-Colburn, Laila, additional, Wolfe, Joanne, additional, Wong, Cynthia J., additional, Worth, Laura L., additional, Wright, Joseph L., additional, Wright, Peter F., additional, Wright, Terry W., additional, Wu, Eveline Y., additional, Wynshaw-Boris, Anthony, additional, Yazigi, Nada, additional, Yogev, Ram, additional, Yudkoff, Marc, additional, Zage, Peter E., additional, Zaidi, Anita K.M., additional, Zeltzer, Lonnie K., additional, Zile, Maija H., additional, Zimmer, Peter, additional, and Zuckerman, Barry, additional

Published
2011
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14. Effects of submicrosecond, high intensity pulsed electric fields on living cells--intracellular electromanipulation

Author

Buescher, E. Stephen and Schoenbach, Karl H.

Subjects
Electric fields -- Research, Dielectrics -- Research, Business, Electronics, Electronics and electrical industries
Abstract

Development of technology to produce nanosecond duration pulsed electric fields has allowed examination of the effects of ultrashort duration, high intensity electric fields on living cells. Theoretically, high intensity (MV/m) electric field applications with durations of less than one microsecond, when shortened toward nanoseconds, should increasingly affect intracellular rather than surface membranes of living cells. Experimentally, square-wave, 60 ns duration, high energy (36-53 kV/cm) pulses applied in trains of 1-10 pulses result in progressive increases in the numbers of permeabilized intracellular granules in a human eosinophil cell model--without large surface membrane effects. Electron micrographic examination of cells treated in this way demonstrates alteration of intracellular granule morphology consistent with permeabilization of granule membrane, i.e., intracellular electromanipulation. Continuous microscopic examination of individual living cells exposed to long or short duration pulsed electric field applications shows that permeabilization of surface membrane (median 5 minutes) with anodic preference (electroporation) and prompt cellular swelling follow a single, long duration (100 microsecond) pulse. In contrast, after a single short duration (60 ns) pulse, onset of surface membrane permeability is delayed (median 17 minutes), the increased permeability shows no anodic preference, and cellular swelling is absent suggesting that these effects are due to intracellular electro-manipulation rather than direct effects on the surface membrane. Submicrosecond, intense pulsed electric fields applied to living cells achieve preferential effects on intracellular rather than surface membranes, potentially providing new approaches for selective/generalized cell or tissue ablation, growth stimulation and tissue remodeling. Index Terms--Pulsed electric field applications, submicrosecond, intracellular effects

Published
2003

15. Clinical experience with linezolid for the treatment of Nocardia infection. (Major Article)

Author

Moylett, Edina H., Pacheco, Susan E., Brown-Elliott, Barbara A., Perry, Tracy R., Buescher, E. Stephen, Birmingham, Mary C., Schentag, Jerome J., Gimbel, Joseph F., Apodaca, Aaron, Schwartz, Margot A., Rakita, Robert M., and Wallace, Richard J., Jr.

Subjects
Nocardia asteroides -- Drug therapy, Antibiotics -- Product information, Antibiotics -- Usage, Pharmaceutical industry -- Product information, Communicable diseases -- Research, Health, Health care industry
Published
2003

16. Bioelectrics--new applications for pulsed power technology

Author

Schoenbach, Karl H., Katsuki, Sunao, Stark, Robert H., Buescher, E. Stephen, and Beebe, Stephen J.

Subjects
Electrophysiology -- Research, Pulse techniques (Electronics) -- Usage, Biological systems -- Analysis, Business, Chemistry, Electronics, Electronics and electrical industries
Abstract

The possibility to control functions and membrane transport processes in biological cells by external pulsed electric fields offers new applications for pulsed power technology. One such application is prevention of biofouling, an effect that is based on reversible electroporation of cell membranes. Pulsed electric fields of several kilovolts per centimeter amplitude and submicrosecond duration have been found to prevent the growth of aquatic nuisance species on surfaces. Reversible electroporation is also used for medical applications, e.g., for delivery of chemotherapeutic drugs into tumor cells, for gene therapy and for transdermal drug delivery. Higher electric fields cause irreversible membrane damage. Pulses in the microsecond range with electric field intensities in the tens of kilovolts per centimeter are used for bacterial decontamination of water and liquid food. A new type of field-cell interaction utilizing nanosecond pulses with electric fields exceeding 50 kV/cm has been recently added to known bioelectric effects. Based on capacitive coupling to cell substructures, it has the potential to affect transport processes across subcellular membranes and may be used for gene transfer into cell nuclei. Other studies indicate that it triggers intracellular processes such as programmed cell death that can be used for cancer treatment. In order to generate the required electric fields for these processes, high-voltage high-current sources are required. The pulse duration needs to be short to prevent thermal effects. Pulse power technology is the enabling technology for this new field of bioengineering, which we have termed 'bioelectrics.' Index Terms--Electroporation, pulsed electric field methods, subcellular effects.

Published
2002

20. Contributors

Author

Adderson, Elisabeth E., primary, Adler-Shohet, Felice C., additional, Amieva, Manuel R., additional, Armstrong, Gregory L., additional, Arvelo, Wences, additional, Arvin, Ann M., additional, Asher, David M., additional, Ashkenazi, Shai, additional, Ault, Kevin A., additional, Baker, Carol J., additional, Barson, William J., additional, Bell, Beth P., additional, Bell, Michael J., additional, Benjamin, Daniel K., additional, Bialek, Stephanie R., additional, Blythe, Margaret J., additional, Bocchini, Joseph A., additional, Boeckh, Michael, additional, Bower, William A., additional, Boyer, Kenneth M., additional, Braden, Christopher R., additional, Bradley, John S., additional, Brady, Michael T., additional, Bratcher, Denise, additional, Braverman, Paula K., additional, Bresee, Joseph S., additional, Brook, Itzhak, additional, Brown, Kevin E., additional, Browning, John C., additional, Buckingham, Steven C., additional, Buescher, E. Stephen, additional, Burns, Jane L., additional, Cappello, Michael, additional, Carter, Bryan D., additional, Chadwick, Ellen Gould, additional, Chesney, Patricia Joan, additional, Childs, James E., additional, Christenson, John C., additional, Cleary, Thomas G., additional, Coffin, Susan E., additional, Connelly, Beverly L., additional, Cotton, C. Michael, additional, Cox, Elaine, additional, Cramer, Robert Andrew, additional, Crockett, Maryanne E., additional, Crowe, James E., additional, Cunningham, Dennis J., additional, Darville, Toni, additional, Dasch, Gregory A., additional, Daum, Robert S., additional, de la Morena, Maite, additional, Demmler, Gail J., additional, Despommier, Dickson D., additional, Diefenbach, Karen A., additional, Dominguez, Elidia, additional, Downs, Stephen M., additional, Dvorak, Christopher C., additional, Edwards, Kathryn, additional, Edwards, Morven S., additional, Englund, Janet A., additional, Erard, Véronique, additional, Eremeeva, Marina E., additional, Finelli, Lyn, additional, Finn, Adam, additional, Fiore, Anthony E., additional, Fischer, Marc, additional, Fitch, Sarah J., additional, Flynn, Patricia M., additional, Fortenberry, J. Dennis, additional, Fox, LeAnne M., additional, Freedman, David O., additional, Gans, Hayley A., additional, Gerber, Michael A., additional, Gigliotti, Francis, additional, Gilligan, Peter, additional, Gold, Benjamin D., additional, Goldman, David L., additional, Goldstein, Brahm, additional, Goldstein, Susan T., additional, Gould, Jane M., additional, Green, Michael, additional, Greene, Sharon K., additional, Greenwald, Mark J., additional, Grom, Alexei A., additional, Grossman, Leigh B., additional, Guerra, Marta A., additional, Gutierrez, Kathleen, additional, Guzman-Cottrill, Judith A., additional, Hall, Caroline Breese, additional, Harper, Marvin B., additional, Haslam, David B., additional, Hayes, Edward B., additional, Hendley, J. Owen, additional, Henrickson, Kelly J., additional, Henry, Marion C.W., additional, Hilinski, Joseph A., additional, Hotez, Peter J., additional, Ingram, David L., additional, Jackson, Mary Anne, additional, Jacobs, Richard F., additional, Karlowicz, M. Gary, additional, Katz, Ben Z., additional, Keystone, Jay S., additional, Kimberlin, David W., additional, Kleiman, Martin B., additional, Klein, Jerome O., additional, Kline, Mark W., additional, Koh, Andrew Y., additional, Koranyi, Katalin I., additional, Korgenski, E. Kent, additional, Leggiadro, Robert J., additional, Levy, Moise L., additional, Lewis, David B., additional, Lieberman, Jay M., additional, Limaye, Abhijit, additional, Lohr, Jacob A., additional, Lorber, Bennett, additional, Long, Sarah S., additional, Low, Donald E., additional, Lowell, Gina, additional, Lowenthal, Elizabeth, additional, Lujan-Zilbermann, Jorge, additional, Luzuriaga, Katherine, additional, MacDonald, Noni E., additional, Maldonado, Yvonne A., additional, Mani, Chitra S., additional, Marcinak, John F., additional, Marcon, Mario J., additional, Marshall, Gary S., additional, Martin, Stacey W., additional, Massung, Robert F., additional, Mast, Eric E., additional, Mazzulli, Tony, additional, McCracken, George H., additional, McGregor, Robert S., additional, McIntosh, Kenneth, additional, McLean, Catherine A., additional, McLeod, Rima, additional, McMillan, Julia A., additional, McQuiston, Jennifer H., additional, Meissner, H. Cody, additional, Menon, Manoj P., additional, Michaels, Marian G., additional, Miller, Melissa B., additional, Millon, Juan Carlos, additional, Modlin, John F., additional, Moore, Matthew R., additional, Moore, Zack S., additional, Moran, Mary M., additional, Moro, Pedro L., additional, Moss, R. Lawrence, additional, Murray, Dennis L., additional, Nadel, Simon, additional, Nataro, James P., additional, Neely, Michael N., additional, Nizet, Victor, additional, Norrby-Teglund, Anna, additional, Nyquist, Ann-Christine, additional, Ochoa, Theresa J., additional, O'Hara, Sara M., additional, Orenstein, Walter A., additional, Ortega-Barria, Eduardo, additional, Overturf, Gary D., additional, Paddock, Christopher D., additional, Painter, John A., additional, Pappas, Diane E., additional, Parise, Monica E., additional, Pass, Robert F., additional, Patterson, Thomas F., additional, Pavia, Andrew T., additional, Pelton, Stephen I., additional, Peter, Georges, additional, Peters, Timothy R., additional, Petri, William A., additional, Pickering, Larry K., additional, Pizzo, Philip A., additional, Pollard, Andrew J., additional, Poutanen, Susan M., additional, Powell, Dwight A., additional, Prince, Alice S., additional, Prober, Charles G., additional, Rangel, Shawn J., additional, Rawstron, Sarah Anne, additional, Reed, Michael D., additional, Reller, Megan E., additional, Richards, Frank O., additional, Rodgers, Gail L., additional, Romero, Luz I., additional, Rotbart, Harley A., additional, Rowley, Anne H., additional, Rubin, Lorry G., additional, Ruiz-Palacios, Guillermo M., additional, Sáez-Llorens, Xavier, additional, Saiman, Lisa, additional, Sauberan, Jason B., additional, Sawyer, Mark H., additional, Schantz, Peter M., additional, Schlager, Theresa A., additional, Schutze, Gordon E., additional, Schwartz, Benjamin, additional, Schwartz, Richard H., additional, Schwarzwald, Heidi, additional, Shah, Samir S., additional, Shane, Andi L., additional, Shapiro, Eugene D., additional, Shetty, Avinash K., additional, Siegel, Jane D., additional, Siegel, Robert D., additional, Sipe, Walter E.B., additional, Skarbinski, Jacek, additional, Smith, P. Brian, additional, Snyder, John D., additional, Solaymani-Mohammadi, Shahram, additional, Staat, Mary Allen, additional, Starke, Jeffrey R., additional, Steinbach, William J., additional, Stephens, Ina, additional, St. Geme, Joseph W., additional, Subbarao, Kanta, additional, Sullivan, John L., additional, Sutton, Deanna A., additional, Sutton, Madeline Y., additional, Swerdlow, David L., additional, Tauxe, Robert V., additional, Thompson, Herbert A., additional, Thomson, Richard B., additional, Thorell, Emily A., additional, Todd, James K., additional, Toltzis, Philip, additional, Tsai, Theodore F., additional, Wald, Ellen R., additional, Wallace, Richard J., additional, Weinberg, Geoffrey A., additional, Weiss, Avery H., additional, White, A. Clinton, additional, Widdowson, Marc-Alain, additional, Williams, Ian T., additional, Williams, John V., additional, Willoughby, Rodney E., additional, Wilson, Craig M., additional, Winkelstein, Jerry A., additional, Workowski, Kimberly, additional, Wright, Terry W., additional, Yazigi, Nada, additional, Yogev, Ram, additional, Young, Edward J., additional, and Zaoutis, Theoklis E., additional

Published
2008
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41. FULMINANT LATE-ONSET SEPSIS IN A NEONATAL INTENSIVE CARE UNIT

Author

Surka, Aqil E., Buescher, E. Stephen, and Karlowicz, M. Gary

Subjects
Pediatrics -- Research
Abstract

Background: The distribution of pathogens causing fulminant late-onset sepsis in the neonatal intensive care unit (NICU) may differ significantly from that causing late-onset sepsis, in general. The difference may be important in selection of empiric antibiotic therapy when fulminant sepsis is suspected. Objective: To determine the pathogens and clinical features associated with fulminant late-onset sepsis in a NICU. Methods: A retrospective study was conducted of sepsis in infants in a NICU over a ten-year period (1988-97). Late-onset sepsis was defined as one or more positive blood cultures obtained after 3 days of age in the presence of clinical features of sepsis. Cultures with the same organism within 30 days of first isolation were considered one episode. Sepsis was defined as fulminant if death occurred within 48 hours of initial blood cultures. Coagulase-negative staphylococcal sepsis was defined as at least two positive blood cultures. Polymicrobial sepsis was counted as multiple individual episodes of sepsis. Cases were identified from a computerized microbiology database. Demographic data were provided by a computerized neonatal database. Clinical features were determined by examination of medical records. Results: There were 6,275 admissions to the NICU over the ten-year study period (1988-97). There were 831 episodes of late-onset sepsis occurring in 542 infants. The most common pathogens were coagulase-negative staphylococci 278 (33%), Candida sp. 143 (17%), Enterococcus sp. 83 (10%), S. aureus 69 (8%), S. agalactiae 36 (4%), and Pseudomonas sp. 36 (4%). There were 49 cases of fulminant late-onset sepsis in 43 infants. Six cases were polymicrobial. Infants with fulminant sepsis had median birth weight = 870 g (range: 437-3515), median gestational age = 26 wk (range: 23-40), and median age of sepsis = 19 days (range: 6-304). The most common causes of fulminant late-onset sepsis were Pseudomonas sp. 20 (40%), E. coli 5 (10%), Enterobacter sp. 4 (8%), Candida sp. 4 (8%), S. aureus 4 (8%), and coagulase-negative staphylococci 4 (8%). Thirty-four of 49 (69%; 95%CI: 55%-82%) cases of fulminant late-onset sepsis were due to gram-negative organisms. The fulminant case fatality rate was highest for Pseudomonas sp., 20 of 36 (56%; 95%CI: 38%-72%) and lowest for coagulase-negative staphylococci, 4 of 278 (1%; 95%CI: 0-4%), odds ratio 86; 95%CI: 26-280. Conclusions: The distribution of pathogens causing fulminant late-onset sepsis in the NICU differed significantly from that causing late-onset sepsis, especially concerning the predominance of Pseudomonas sp. and other gram-negative organisms. When fulminant sepsis is suspected, the selection of empiric antibiotic therapy should account for these differences., Aqil E. Surka, MD E. Stephen Buescher, MD, M. Gary Karlowicz, MD, FAAP; Department of Pediatrics, Eastern Virginia Medical School, Norfolk, [...]

Published
1999

49. Colaboradores

Author

Abzug, Mark J., Adams, David R., Adelson, Stewart L., Aiken, John J., Akay, Begum, Akdis, Cezmi A., Alessandrini, Evaline A., Alexander, Michael A., Ali, Omar, Ambalavanan, Namasivayam, Anderson, Karl E., Anderson, Peter M., Anthony, Kelly K., Antoon, Alia Y., Apkon, Susan D., Ardoin, Stacy P., Ardura, Monica I., Ariss, Michelle M., Armangué, Thaís, Arndt, Carola A.S., Arnon, Stephen S., Aronoff, Stephen C., Asher, David M., Ashworth, Ann, Asselin, Barbara L., Ater, Joann L., Augustine, Erika F., Augustyn, Marilyn C., Avner, Ellis D., Bacino, Carlos A., Baldassano, Robert N., Baldwin, Keith D., Bales, Christina, Balistreri, William F., Baltimore, Robert S., Balwani, Manisha, Barron, Christine E., Barron, Karyl S., Bass, Dorsey M., Batshaw, Mark L., Bauer, Nerissa S., Bayer, Michelle L., Behrman, Richard E., Bell, Michael J., Belmont, John W., Benjamin, Daniel K., Jr., Bennett, Michael J., Benseler, Susanne M., Bernstein, Daniel, Bhutta, Zulfiqar Ahmed, Blanchard, Samra S., Blatter, Joshua A., Bleyer, Archie, Boas, Steven R., Bockting, Walter O., Boerkoel, Neal F., Bogdanovic, Natalija, Boguniewicz, Mark, Bonthius, Daniel J., Bordini, Brett J., Boyer, Kenneth M., Brandow, Amanda M., Branski, David, Breault, David T., Britt, William J., Bryan, Angela R., Buckley, Rebecca H., Budek, Cynthia Etzler, Buescher, E. Stephen, Bunyavanich, Supinda, Burnham, Carey-Ann D., Burstein, Gale R., Bustinduy, Amaya L., Cabada, Miguel M., Caglar, Derya, Cairo, Mitchell S., Camarda, Lauren E., Camitta, Bruce M., Campbell, Angela J.P., Carlo, Waldemar A., Carrigan, Robert B., Caserta, Mary T., Casey, Denise, Chadwick, Ellen Gould, Chamberlain, Lisa J., Chapman, Jennifer I., Cheifetz, Ira M., Chemaitilly, Wassim, Chen, Yuan-Tsong, Chesney, Russell W., Chiriboga, Jennifer A., Chiu, Yvonne E., Cho, Christine B., Christensen, Robert D., Chu, Andrew, Chusid, Michael J., Cieslak, Col. Theodore J., Clark, Jeff A., Cleary, Thomas G., Clemens, John David, Coates, Bria M., Coates, Thomas D., Cohen, Joanna S., Cohen, Mitchell B., Cohen-Wolkowiez, Michael, Colbert, Robert A., Cole, F. Sessions, III, Colombo, John L., Congeni, Joseph A., Conroy, Christine M., Cooper, Amber R., Covar, Ronina A., Crowe, James E., Jr., Czinn, Steve J., Dalmau, Josep O., Darville, Toni, Daum, Robert S., Davidson, Loren T., Davidson, Richard S., Davies, H. Dele, Daw, Najat C., Dayan, Peter S., DeBaun, Michael R., DeMaso, David R., Denison, Mark R., Dent, Arlene E., Desnick, Robert J., deVeber, Gabrielle A., Dhawan, Anil, Dick, André A.S., Dickey, Brianne Z., Dietz, Harry C., III, Donoghue, Lydia J., Donohoue, Patricia A., Donovan, Mary K., Dormans, John P., Dougherty, Kelly A., Doyle, Alexander, Doyle, Daniel A., Doyle, Jefferson J., Drayna, Patrick C., Dreskin, Stephen C., Drolet, Beth A., Dror, Yigal, Dubowitz, Howard, Dumler, J. 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Owen, Henretig, Frederick M., Heresi, Gloria P., Hershey, Andrew D., Herzog, Cynthia E., Hochberg, Jessica, Hoefgen, Holly R., Holinger, Lauren D., Holland-Hall, Cynthia, Hord, Jeffrey D., Horn, B. David, Horstmann, Helen M., Horton, William A., Hotez, Peter J., Hsu, Evelyn, Huang, Stephen A., Huddleston, Heather G., Huff, Vicki, Hug, Denise, Hughes, Dennis P.M., Huh, Winston W., Humphrey, Stephen R., Hunstad, David A., Hunt, Carl E., Hunter, Anna K., Huppert, Stacey S., Ibeziako, Patricia I., Ibrahim, Samar H., Jacobs, Richard F., Jatlaoui, Tara, Jensen, M. Kyle, Jenson, Hal B., John, Chandy C., John, Collin C., Johnston, Michael V., Johnston, Richard B., Jr., Jones, Bridgette L., Jones, James F., Joselow, Marsha, Jospe, Nicholas, Joyce, Joel C., Juern, Anna M., Kabbouche, Marielle A., Kaljee, Linda, Kamat, Deepak, Kansra, Alvina R., Kaplan, Sheldon L., Karlin, Aaron M., Kastner, Daniel L., Katz, Emily R., Kazura, James W., Keane, Virginia A., Kearns, Gregory L., Keesecker, Sarah E., Kelly, Desmond P., Kelly, Kevin J., Kelly, Matthew S., Kelsen, Judith R., Kemper, Kathi J., Kennedy, Melissa, Kerem, Eitan, Kerschner, Joseph E., Khan, Seema, Kim, Jennifer S., King, Charles H., Kinsman, Stephen L., Kirton, Adam, Kishnani, Priya S., Kitts, Robert L., Kleiman, Martin B., Klein, Bruce L., Klein, Bruce S., Klein, Michael D., Kliegman, Robert M., Koch, William C., Kochanek, Patrick M., Kodish, Eric, Kohlhoff, Stephan A., Kostic, Mark A., Krach, Linda E., Krane, Elliot J., Krause, Peter J., Kreipe, Richard E., Krug, Steven E., Kuttesch, John F., Jr., Kwon, Jennifer M., Lachenauer, Catherine S., Ladisch, Stephan, LaFranchi, Stephen H., Lakser, Oren J., Lande, Marc B., Landrigan, Philip J., Landry, Gregory L., Lane, Wendy G., LaRussa, Phillip S., Lawrence, J. Todd R., Lee, Brendan, Lee, K. Jane, Leeder, J. Steven, Lehman, Rebecca K., Lentze, Michael J., Lerner, Norma B., Lestrud, Steven O., Leung, Donald Y.M., Liacouras, Chris A., Liebig, Christopher W., Lindquist, Timothy P., Liu, Andrew H., Lo, Stanley F., Locatelli, Franco, Lockhart, John H., Long, Sarah S., Lopez, Anna Lena, Lossef, Steven V., Lowry, Jennifer A., MacZura, Nora T., Mahajan, Prashant V., Maheshwari, Akhil, Majzoub, Joseph A., Maqbool, Asim, Maranich, Ashley M., Marin, Mona, Marini, Joan C., Markello, Thomas C., Markowitz, Morri, Marks, Kevin P., Maroushek, Stacene R., Martin, Kari L., Mason, Wilbert H., Jr., Mastropietro, Christopher, Matalon, Kimberlee M., Matalon, Reuben K., Mathew, Roshni, Matthews, Dennis J., Mazor, Robert L., McCabe, Megan E., McColley, Susanna A., McGovern, Margaret M., McLean, Heather S., McLeod, Rima, McMahon, Mary A., Mejias, Asuncion, Melby, Peter C., Menchise, Alexandra N., Merritt, Diane F., Mezoff, Ethan A., Michaels, Marian G., Mikati, Mohamad A., Milgrom, Henry, Miller, E. Kathryn, Mink, Jonathan W., Mistovich, R. Justin, Mitchell, Grant A., Morgan-DeWitt, Esi, Moscicki, Anna-Barbara, Moseley, Lovern R., Moughan, Beth, Murphy, James R., Murphy, Kevin P., Murphy, Timothy F., Murray, Thomas S., Myers, René P., Natale, Mindo J., Neal, William A., Nelson, Maureen R., Ness, Jayne M., Neville, Kathleen A., Nevin, Mary A., Newburger, Jane W., Newburger, Peter E., Nield, Linda S., Niermeyer, Susan, Noah, Zehava L., Nogee, Lawrence M., Norris, Robert L., Nowak-Wȩgrzyn, Anna, Obaro, Stephen K., Obeid, Makram M., O’ Brien, Hope L., Ochoa, Theresa J., Ohls, Robin K., Okwo-Bele, Jean-Marie, Oldham, Keith T., Oleszek, Joyce L., Olitsky, Scott E., Olsson, John M., Ombrello, Amanda K., Orenstein, Susan R., Orenstein, Walter A., Osorio, Marisa, Toole, Patrick O’, Owens, Judith A., Özen, Seza, Packman, Charles H., Pais, Priya, Palermo, Tonya M., Pan, Cynthia G., Pappas, Diane E., Parks, Elizabeth P., Parks, John S., Patterson, Maria Jevitz, Peters, Timothy R., Pickering, Larry K., Pless, Misha L., Plummer, Laura S., Pollard, Andrew J., Porter, Craig C., Preciado, Diego, Price, David T., Prober, Charles G., Pruitt, David W., Quan, Linda, Quint, Elisabeth H., Rabinovich, C. Egla, Raffini, Leslie J., Ramilo, Octavio, Ramirez-Montealegre, Denia, Rashid, Asma, Raviola, Giuseppe J., Raymond, Gerald V., Reed, Ann M., Rekate, Harold L., Reller, Megan E., Reyes, Jorges D., Rezvani, Geoffrey A., Rezvani, Iraj, Ritchey, A. Kim, Rivara, Frederick P., Robilotti, Elizabeth V., Robinson, Angela Byun, Roosevelt, Genie E., Rosenberg, David R., Rosenblatt, David S., Roskind, Cindy Ganis, Ross, A. Catharine, Rotar, Mary M., Rozenfeld, Ranna A., Ryan, Colleen A., Sachdev, H.P.S., Sachdeva, Ramesh C., Sadarangani, Manish, Sadun, Rebecca E., Sahin, Mustafa, Salata, Robert A., Salerno, Denise A., Salvana, Edsel Maurice T., Sampson, Hugh A., Sandora, Thomas J., Sandritter, Tracy L., Sankar, Wudbhav N., Sarkissian, Eric J., Sarnaik, Ajit A., Sarnaik, Ashok P., Sarnat, Harvey B., Sarwal, Minnie M., Schanberg, Laura E., Schleiss, Mark R., Schor, Nina F., Schroeder, Bill J., Schroeder, James W., Jr., Schuster, Mark A., Schutze, Gordon E., Scott, Daryl A., Scott, J. Paul, Seed, Patrick C., Segel, George B., Seidman, Ernest G., Serwint, Janet R., Shah, Dheeraj, Shaikhkhalil, Ala, Shamir, Raanan, Shane, Andi L., Shapiro, Bruce K., Shaw, Amanda N., Shaywitz, Bennett A., Shaywitz, Sally E., Sherman, Philip M., Shneider, Benjamin L., Shulman, Stanford T., Sicherer, Scott H., Sills, Richard, Simms, Mark D., Simões, Eric A.F., Simonsen, Kari A., Slavotinek, Anne, Slovis, Thomas L., Smith, P. Brian, Son, Mary Beth F., Sosinsky, Laura Stout, Spahn, Joseph D., Spalter, Rivkie, Sperling, Mark A., Spicer, Robert L., Spiegel, David A., Spoudeas, Helen, Spranger, Jürgen W., Squires, James E., Sreedharan, Rajasree, Sreedharan, Raman, Srinivas, Nivedita, Stager, Margaret M., Stahl, Erin D., Stallings, Amy P., Stallings, Virginia A., Stambough, Kathryn C., Stanberry, Lawrence R., Stanley, Charles A., Stanton, Bonita F., Starke, Jeffrey R., Stechenberg, Barbara W., Steinbach, William J., Stewart, Janet, Stoll, Barbara J., Storch, Gregory A., Strauss, Ronald G., Sucato, Gina S., Suchy, Frederick J., Svoren, Britta M., Swanson, Stephen J., Szilagyi, Moira, Tan, Libo, Tanz, Robert R., Tarek, Nidale, Tifft, Cynthia J., Tinanoff, Norman, Todd, James K., Tompkins, Lucy S., Tower, Richard L., II, Trieu, Michael L., Troncone, Riccardo, Tubergen, David G., Turk, Margaret A., Turner, David A., Ullrich, Christina, Urion, David K., Vanderbilt, Douglas, Vanderhoof, Jon A., Van Hare, George F., van Ingen, Jakko, Van Mater, Heather A., van Soolingen, Dick, VanTubbergen, Christine, Van Why, Scott K., Velardi, Andrea, Vichinsky, Elliott P., Vickery, Brian P., Vitola, Bernadette E., Voynow, Judith A., Waggoner-Fountain, Linda A., Waguespack, Steven G., Walker, David M., Walkovich, Kelly J., Wallihan, Rebecca, Walter, Heather J., Wang, Julie, Ware, Stephanie M., Weese-Mayer, Debra E., Weinberg, Jason B., Weise, Kathryn L., Weiss, Pamela F., Weisse, Martin E., Wells, Lawrence, Wen, Jessica W., Wendel, Danielle, Werlin, Steven L., Wessels, Michael R., Wetmore, Ralph F., Wetzel, Randall C., Wexler, Isaiah D., Wharff, Elizabeth A., White, A. Clinton, Jr., White, Perrin C., Williams, John V., Willoughby, Rodney E., Jr., Wilschanski, Michael, Wilson, Pamela, Wilson, Samantha L., Winell, Jennifer J., Winnie, Glenna B., Winter, Harland S., Wise, Paul H., Wolf, Joshua, Wolfe, Joanne, Wood, James B., Worth, Laura L., Wright, Joseph L., Wright, Terry W., Wu, Eveline Y., Yagupsky, Pablo, Yaron, Michael, Yogev, Ram, Yu, JiaDe, Yudkoff, Marc, Zage, Peter E., Zakhour, Ramia, Zeltzer, Lonnie K., Zimmer, Klaus-Peter, Zoran, Naama, and Zuckerman, Barry S.

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2018
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