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5. [Antitumor effect of joint action of low intensity electromagnetic fields and ultra low doses of doxorubicin].

Author

Ostrovskaia LA, Budnik MI, Korman DB, Bliukhterova NV, Fomina MM, Rykova VA, and Burlakova EB

Subjects
Animals, Cell Division drug effects, Cell Division radiation effects, Dose-Response Relationship, Drug, Dose-Response Relationship, Radiation, Mice, Mice, Inbred Strains, Antineoplastic Agents pharmacology, Carcinoma, Lewis Lung drug therapy, Carcinoma, Lewis Lung radiotherapy, Doxorubicin pharmacology, Electromagnetic Fields, Radiation
Abstract

Combined action of a low intensive physical factor and a chemotherapeutic agent in ultralow doses against Lewis lung carcinoma was studied. Antitumor activity of low intensiwe electromagnetic field was expressed as inhibition of tumor growth at 60% compare to control. Ultra low doses of doxorubicin as well as its standard dose resulted in inhibition of tumor growth by 60-70% in comparison with control. Joint action of both factors leaded to increasing in the antitumor effect that reached such level of tumor growth inhibition as 85% relative to control.

Published
2003

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