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1. Klinische Entscheidungsfindung mit Künstlicher Intelligenz

Author

Samhammer, David, Beck, Susanne, Budde, Klemens, Burchardt, Aljoscha, Faber, Michelle, Gerndt, Simon, Möller, Sebastian, Osmanodja, Bilgin, Roller, Roland, and Dabrock, Peter

Subjects
Künstliche Intelligenz, Maschinelles Lernen, Medizin, Klinik, Entscheidungsfindung, Meaningful Human Control, Bedeutsame menschliche Kontrolle, Governance, Medizinische Unterstützungssysteme, thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine, thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCV Economics of specific sectors::KCVJ Health economics, thema EDItEUR::M Medicine and Nursing::MQ Nursing and ancillary services::MQC Nursing, thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTQ Ethics and moral philosophy, thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJR Renal medicine and nephrology
Abstract

​Dieses Open-Access-essential schafft Orientierung, wenn Künstliche Intelligenz im klinischen Alltag eingesetzt wird. Die Herausforderungen werden anhand zweier Beispiele aus dem Bereich der Nephrologie erläutert, die ethisch und rechtlich reflektiert werden. Ein umfangreicher Empfehlungsteil schließt diesen durchweg interdisziplinär erarbeiteten Band ab.

Published
2023
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7. A Medical Information Extraction Workbench to Process German Clinical Text

Author

Roller, Roland, Seiffe, Laura, Ayach, Ammer, Möller, Sebastian, Marten, Oliver, Mikhailov, Michael, Alt, Christoph, Schmidt, Danilo, Halleck, Fabian, Naik, Marcel, Duettmann, Wiebke, and Budde, Klemens

Subjects
Computer Science - Computation and Language
Abstract

Background: In the information extraction and natural language processing domain, accessible datasets are crucial to reproduce and compare results. Publicly available implementations and tools can serve as benchmark and facilitate the development of more complex applications. However, in the context of clinical text processing the number of accessible datasets is scarce -- and so is the number of existing tools. One of the main reasons is the sensitivity of the data. This problem is even more evident for non-English languages. Approach: In order to address this situation, we introduce a workbench: a collection of German clinical text processing models. The models are trained on a de-identified corpus of German nephrology reports. Result: The presented models provide promising results on in-domain data. Moreover, we show that our models can be also successfully applied to other biomedical text in German. Our workbench is made publicly available so it can be used out of the box, as a benchmark or transferred to related problems., Comment: Paper under review since 2021

Published
2022

8. When Performance is not Enough -- A Multidisciplinary View on Clinical Decision Support

Author

Roller, Roland, Budde, Klemens, Burchardt, Aljoscha, Dabrock, Peter, Möller, Sebastian, Osmanodja, Bilgin, Ronicke, Simon, Samhammer, David, and Schmeier, Sven

Subjects
Computer Science - Machine Learning, Computer Science - Computers and Society
Abstract

Scientific publications about machine learning in healthcare are often about implementing novel methods and boosting the performance - at least from a computer science perspective. However, beyond such often short-lived improvements, much more needs to be taken into consideration if we want to arrive at a sustainable progress in healthcare. What does it take to actually implement such a system, make it usable for the domain expert, and possibly bring it into practical usage? Targeted at Computer Scientists, this work presents a multidisciplinary view on machine learning in medical decision support systems and covers information technology, medical, as well as ethical aspects. Along with an implemented risk prediction system in nephrology, challenges and lessons learned in a pilot project are presented., Comment: Paper currently under review

Published
2022

9. Evaluation of non-invasive biomarkers of kidney allograft rejection in a prospective multicenter unselected cohort study (EU-TRAIN)

Author

Goutaudier, Valentin, Danger, Richard, Catar, Rusan Ali, Racapé, Maud, Philippe, Aurélie, Elias, Michelle, Raynaud, Marc, Aubert, Olivier, Bouton, Didier, Girardin, François, Vicaut, Éric, Yaiche, Sarhan, Demotes, Jacques, Heidecke, Harald, Taupin, Jean-Luc, Randoux-Lebrun, Christine, Zaidan, Mohamad, Papuchon, Emmanuelle, Le Mai, Hoa, Nguyen, Thi-Van-Ha, Moreso, Francesc, Berney, Thierry, Villard, Jean, Legendre, Christophe, Dragun, Duska, Papalois, Vassilios, Potena, Luciano, Giral, Magali, Gourraud, Pierre-Antoine, Brouard, Sophie, Crespo, Elena, Halleck, Fabian, Budde, Klemens, Bestard, Oriol, Loupy, Alexandre, and Lefaucheur, Carmen

Published
2024
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10. Möglichkeiten der Gestaltung

Author

Samhammer, David, Beck, Susanne, Budde, Klemens, Burchardt, Aljoscha, Faber, Michelle, Gerndt, Simon, Möller, Sebastian, Osmanodja, Bilgin, Roller, Roland, Dabrock, Peter, Samhammer, David, Beck, Susanne, Budde, Klemens, Burchardt, Aljoscha, Faber, Michelle, Gerndt, Simon, Möller, Sebastian, Osmanodja, Bilgin, Roller, Roland, and Dabrock, Peter

Published
2023
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11. Rechtliche Konkretisierung

Author

Samhammer, David, Beck, Susanne, Budde, Klemens, Burchardt, Aljoscha, Faber, Michelle, Gerndt, Simon, Möller, Sebastian, Osmanodja, Bilgin, Roller, Roland, Dabrock, Peter, Samhammer, David, Beck, Susanne, Budde, Klemens, Burchardt, Aljoscha, Faber, Michelle, Gerndt, Simon, Möller, Sebastian, Osmanodja, Bilgin, Roller, Roland, and Dabrock, Peter

Published
2023
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12. Ethische Reflexion

Author

Samhammer, David, Beck, Susanne, Budde, Klemens, Burchardt, Aljoscha, Faber, Michelle, Gerndt, Simon, Möller, Sebastian, Osmanodja, Bilgin, Roller, Roland, Dabrock, Peter, Samhammer, David, Beck, Susanne, Budde, Klemens, Burchardt, Aljoscha, Faber, Michelle, Gerndt, Simon, Möller, Sebastian, Osmanodja, Bilgin, Roller, Roland, and Dabrock, Peter

Published
2023
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13. Perspektiven von Patient:innen und des medizinischen Personals – Anwendungsfälle von KI in der Nephrologie

Author

Samhammer, David, Beck, Susanne, Budde, Klemens, Burchardt, Aljoscha, Faber, Michelle, Gerndt, Simon, Möller, Sebastian, Osmanodja, Bilgin, Roller, Roland, Dabrock, Peter, Samhammer, David, Beck, Susanne, Budde, Klemens, Burchardt, Aljoscha, Faber, Michelle, Gerndt, Simon, Möller, Sebastian, Osmanodja, Bilgin, Roller, Roland, and Dabrock, Peter

Published
2023
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15. A multicentre, patient- and assessor-blinded, non-inferiority, randomised and controlled phase II trial to compare standard and torque teno virus-guided immunosuppression in kidney transplant recipients in the first year after transplantation: TTVguideIT

Author

Haupenthal, Frederik, Rahn, Jette, Maggi, Fabrizio, Gelas, Fanny, Bourgeois, Philippe, Hugo, Christian, Jilma, Bernd, Böhmig, Georg A., Herkner, Harald, Wolzt, Michael, Doberer, Konstantin, Vossen, Matthias, Focosi, Daniele, Neuwirt, Hannes, Banas, Miriam, Banas, Bernhard, Budde, Klemens, Viklicky, Ondrej, Malvezzi, Paolo, Rostaing, Lionel, Rotmans, Joris I., Bakker, Stephan J. L., Eller, Kathrin, Cejka, Daniel, Pérez, Alberto Molina, Rodriguez-Arias, David, König, Franz, and Bond, Gregor

Published
2023
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16. The Banff 2022 Kidney Meeting Work Plan: Data-driven refinement of the Banff Classification for renal allografts

Author

Roufosse, Candice, Naesens, Maarten, Haas, Mark, Lefaucheur, Carmen, Mannon, Roslyn B., Afrouzian, Marjan, Alachkar, Nada, Aubert, Olivier, Bagnasco, Serena M., Batal, Ibrahim, Bellamy, Chris O.C., Broecker, Verena, Budde, Klemens, Clahsen-Van Groningen, Marian, Coley, Shana M., Cornell, Lynn D., Dadhania, Darshana, Demetris, Anthony J., Einecke, Gunilla, Farris, Alton B., Fogo, Agnes B., Friedewald, John, Gibson, Ian W., Horsfield, Catherine, Huang, Edmund, Husain, Syed A., Jackson, Annette M., Kers, Jesper, Kikić, Željko, Klein, Amanda, Kozakowski, Nicolas, Liapis, Helen, Mangiola, Massima, Montgomery, Robert A., Nankinvell, Brian, Neil, Desley A.H., Nickerson, Peter, Rabant, Marion, Randhawa, Parmjeet, Riella, Leonardo V., Rosales, Ivy, Royal, Virginie, Sapir-Pichhadze, Ruth, Sarder, Pinaki, Sarwal, Minnie, Schinstock, Carrie, Stegall, Mark, Solez, Kim, van der Laak, Jeroen, Wiebe, Chris, Colvin, Robert B., Loupy, Alexandre, and Mengel, Michael

Published
2024
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17. Clinical Outcome Prediction from Admission Notes using Self-Supervised Knowledge Integration

Author

van Aken, Betty, Papaioannou, Jens-Michalis, Mayrdorfer, Manuel, Budde, Klemens, Gers, Felix A., and Löser, Alexander

Subjects
Computer Science - Computation and Language
Abstract

Outcome prediction from clinical text can prevent doctors from overlooking possible risks and help hospitals to plan capacities. We simulate patients at admission time, when decision support can be especially valuable, and contribute a novel admission to discharge task with four common outcome prediction targets: Diagnoses at discharge, procedures performed, in-hospital mortality and length-of-stay prediction. The ideal system should infer outcomes based on symptoms, pre-conditions and risk factors of a patient. We evaluate the effectiveness of language models to handle this scenario and propose clinical outcome pre-training to integrate knowledge about patient outcomes from multiple public sources. We further present a simple method to incorporate ICD code hierarchy into the models. We show that our approach improves performance on the outcome tasks against several baselines. A detailed analysis reveals further strengths of the model, including transferability, but also weaknesses such as handling of vital values and inconsistencies in the underlying data., Comment: EACL 2021

Published
2021

18. Deceased donor urinary Dickkopf-3 associates with future allograft function following kidney transplantation

Author

Fallois, Jonathan de, Günzel, Anna, Daniel, Christoph, Stumpf, Julian, Busch, Martin, Pein, Ulrich, Paliege, Alexander, Amann, Kerstin, Wiech, Thorsten, Hantmann, Elena, Wolf, Gunter, Pfeifer, Felix, Girndt, Matthias, Lindner, Tom H., Weimann, Antje, Seehofer, Daniel, Bachmann, Anette, Budde, Klemens, Biemann, Ronald, Isermann, Berend, Engel, Christoph, Dittrich, Katalin, Hugo, Christian, and Halbritter, Jan

Published
2024
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19. Subthreshold rejection activity in many kidney transplants currently classified as having no rejection

Author

Halloran, Philip F., Madill-Thomsen, Katelynn S., Böhmig, Georg, Bromberg, Jonathan, Budde, Klemens, Barner, Meagan, Mackova, Martina, Chang, Jessica, Einecke, Gunilla, Eskandary, Farsad, Gupta, Gaurav, Myślak, Marek, Viklicky, Ondrej, Akalin, Enver, Alhamad, Tarek, Anand, Sanjiv, Arnol, Miha, Baliga, Rajendra, Banasik, Mirosław, Bingaman, Adam, Blosser, Chris, Brennan, Daniel, Chamienia, Andrzej, Chow, Kevin, Ciszek, Michał, de Freitas, Declan, Dęborska-Materkowska, Dominika, Debska-Ślizień, Alicja, Djamali, Arjang, Domański, Leszek, Durlik, Magdalena, Fatica, Richard, Francis, Iman, Fryc, Justyna, Gill, John, Gill, Jagbir, Glyda, Maciej, Gourishankar, Sita, Grenda, Ryszard, Gryczman, Marta, Hruba, Petra, Hughes, Peter, Jittirat, Arskarapurk, Jurekovic, Zeljka, Kamal, Layla, Kamel, Mahmoud, Kant, Sam, Kasiske, Bertram, Kojc, Nika, Konopa, Joanna, Lan, James, Mannon, Roslyn, Matas, Arthur, Mazurkiewicz, Joanna, Miglinas, Marius, Mueller, Thomas, Narins, Seth, Naumnik, Beata, Patel, Anita, Perkowska-Ptasińska, Agnieszka, Picton, Michael, Piecha, Grzegorz, Poggio, Emillio, Rajnochová Bloudíčkova, Silvie, Samaniego-Picota, Milagros, Schachtner, Thomas, Shin, Sung, Shojai, Soroush, Sikosana, Majid, Slatinská, Janka, Smykal-Jankowiak, Katarzyna, Solanki, Ashish, Veceric Haler, Željka, Vucur, Ksenija, Weir, Matthew R., Wiecek, Andrzej, Włodarczyk, Zbigniew, Yang, Harold, and Zaky, Ziad

Published
2024
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20. Fixed low dose versus concentration-controlled initial tacrolimus dosing with reduced target levels in the course after kidney transplantation: results from a prospective randomized controlled non-inferiority trial (Slow & Low study)

Author

Girndt, Matthias, Wolf, Gunter, Kurschat, Christine, Lopau, Kai, Lutz, Jens, Stumpf, Julian, Budde, Klemens, Witzke, Oliver, Sommerer, Claudia, Vogel, Thomas, Schenker, Peter, Woitas, Rainer Peter, Opgenoorth, Mirian, Trips, Evelyn, Schrezenmeier, Eva, and Hugo, Christian

Published
2024
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21. An automated histological classification system for precision diagnostics of kidney allografts

Author

Yoo, Daniel, Goutaudier, Valentin, Divard, Gillian, Gueguen, Juliette, Astor, Brad C., Aubert, Olivier, Raynaud, Marc, Demir, Zeynep, Hogan, Julien, Weng, Patricia, Smith, Jodi, Garro, Rouba, Warady, Bradley A., Zahr, Rima S., Sablik, Marta, Twombley, Katherine, Couzi, Lionel, Berney, Thierry, Boyer, Olivia, Duong-Van-Huyen, Jean-Paul, Giral, Magali, Alsadi, Alaa, Gourraud, Pierre A., Morelon, Emmanuel, Le Quintrec, Moglie, Brouard, Sophie, Legendre, Christophe, Anglicheau, Dany, Villard, Jean, Zhong, Weixiong, Kamar, Nassim, Bestard, Oriol, Djamali, Arjang, Budde, Klemens, Haas, Mark, Lefaucheur, Carmen, Rabant, Marion, and Loupy, Alexandre

Published
2023
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22. Challenges in the management of the kidney allograft: from decline to failure: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Author

Ahn, Curie, Alberú, Josefina, Baliker, Mary, Bamgboye, Ebun L., Barber, Thelma, Bensouda, Melissa, Chadban, Steve J., Dadhania, Darshana M., Dębska-Ślizień, Alicja, Devresse, Arnaud, Ditzen, Beate, Fowler, Kevin, Gill, John S., Jha, Vivekanand, Khairallah, Pascale, Knoll, Greg A., Korst, Uwe, Lee, Austin, Legendre, Christophe, Lentine, Krista L., Lerma, Edgar V., Lorenz, Elizabeth C., Matas, Arthur J., Mohan, Sumit, Nazarewski, Sławomir, Noronha, Irene L., Obrador, Gregorio T., Parekh, Rulan S., Pavlakis, Martha, Pascual, Julio, Pilmore, Helen L., Rosenkranz, Alexander R., Rozen-Zvi, Benaya, Roy-Chaudhury, Prabir, Tanabe, Kazunari, Wanner, Christoph, Wasse, Haimanot, Yang, Chul-Woo, Josephson, Michelle A., Becker, Yolanda, Budde, Klemens, Kasiske, Bertram L., Kiberd, Bryce A., Loupy, Alexandre, Małyszko, Jolanta, Mannon, Roslyn B., Tönshoff, Burkhard, Cheung, Michael, Jadoul, Michel, Winkelmayer, Wolfgang C., and Zeier, Martin

Published
2023
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23. Using Regression Equations to Enhance Interpretation of Histology Lesions of Kidney Transplant Rejection

Author

Sikosana, Majid L.N., Reeve, Jeff, Madill-Thomsen, Katelynn S., Halloran, Philip F., Mannon, Roslyn, Serón, Daniel, Sellares, Joanna, Akalin, Enver, de Freitas, Declan, Picton, Michael, Bromberg, Jonathan, Weir, Matt, Budde, Klemens, Heinbokel, Timm, Einecke, Gunilla, Yang, Harold, Narins, Seth, Samaniego-Picota, Milagros, Myslak, Marek, Perkowska-Ptasinska, Agnieszka, Bingaman, Adam, Brennan, Daniel, Malone, Andrew, Kasiske, Bertram, Matas, Arthur, Djamali, Arjang, Böhmig, Georg, Eskandary, Farsad, and Gupta, Gaurav

Published
2024
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26. Novel transcriptomic signatures associated with premature kidney allograft failure

Author

Hruba, Petra, Klema, Jiri, Le, Anh Vu, Girmanova, Eva, Mrazova, Petra, Massart, Annick, Maixnerova, Dita, Voska, Ludek, Piredda, Gian Benedetto, Biancone, Luigi, Puga, Ana Ramirez, Seyahi, Nurhan, Sever, Mehmet Sukru, Weekers, Laurent, Muhfeld, Anja, Budde, Klemens, Watschinger, Bruno, Miglinas, Marius, Zahradka, Ivan, Abramowicz, Marc, Abramowicz, Daniel, and Viklicky, Ondrej

Published
2023
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27. A paired-kidney allocation study found superior survival with HLA-DR compatible kidney transplants in the Eurotransplant Senior Program

Author

Tieken, I., Haasnoot, G., van Meel, M., Rump, L.C., Rosenkranz, A., Horn, S., Margreiter, R., Schneeberger, S., Oberbauer, R., Pohanka, E., Függer, F., Mühlbacher, F., Berlakovich, G., Meurisse, M., Weekers, L., Ysebaert, D., Wissing, K.M., Mikhalski, D., Mourad, M., van Biesen, W., Kuypers, D., Floege, J., Anthuber, M., Viebahn, R., Schenker, P., Budde, K., Pratschke, J., Zidek, W., Melchior, S., Woitas, R., Strassburg, C.H., Hugo, C., Wirth, M., Schiffer, M., Kribben, A., Pisarski, P., Fichtner-Feigl, S., Haubitz, M., Weimer, R., Weithofer, P., Fornara, P., Fisher, L., Sester, U., Zeier, M., Kliem, V., Klempnauer, l, Grimm, M.O., Kunzendorf, U., Stippel, D., Arns, W., Mönch, C., Nitschke, M., Bartels, M., Krämer, B., Kruger, B., Heemann, U., Werner, J., Hoyer, J., Wolters, H.H., Suwelack, B., Lutz, J., Banas, B., Hakenberg, O., Olbricht, C.J., Kalus, M., Schwenger, V., Nadalin, S., Schröppel, B., Lopau, K., Seelen, M.A.J., Berger, S.P., de Fijter, J.W., van der Linden, S.J., Christiaans, M.H.L., van de Wetering, J., van Zuilen, A.D., Bemelman, F., Nurmohamed, A., Hilbrands, L., de Fijter, Johan, Dreyer, Geertje, Mallat, Marko, Budde, Klemens, Pratschke, Johann, Klempnauer, Jürgen, Zeier, Martin, Arns, Wolfgang, Hugo, Christian, Rump, Lars-Christian, Hauser, Ingeborg, Schenker, Peter, Schiffer, Mario, Grimm, Marc-Oliver, Kliem, Volker, Olbricht, Christoph J., Pisarski, Przemyslaw, Banas, Bernhard, Suwelack, Barbara, Hakenberg, Oliver, Berlakovich, Gabriela, Schneeberger, Stefan, van de Wetering, Jacqueline, Berger, Stefan, Bemelman, Frederike, Kuypers, Dirk, Heidt, Sebastiaan, Rahmel, Axel, Claas, Frans, Peeters, Patrick, Oberbauer, Rainer, Heemann, Uwe, and Krämer, Bernhard K.

Published
2023
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28. Using Regression Equations to Enhance Interpretation of Histology Lesions of Kidney Transplant Rejection

Author

Sikosana, Majid L.N., Reeve, Jeff, Madill-Thomsen, Katelynn S., Halloran, Philip F., Mannon, Roslyn, Serón, Daniel, Sellares, Joanna, Akalin, Enver, de Freitas, Declan, Picton, Michael, Bromberg, Jonathan, Weir, Matt, Budde, Klemens, Heinbokel, Timm, Einecke, Gunilla, Yang, Harold, Narins, Seth, Samaniego-Picota, Milagros, Myslak, Marek, Perkowska-Ptasinska, Agnieszka, Bingaman, Adam, Brennan, Daniel, Malone, Andrew, Kasiske, Bertram, Matas, Arthur, Djamali, Arjang, Böhmig, Georg, Eskandary, Farsad, and Gupta, Gaurav

Published
2023
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29. Novel approaches to sarcopenic obesity and weight management before and after kidney transplantation.

Author

Tantisattamo, Ekamol, Kalantar-Zadeh, Kamyar, Halleck, Fabian, Duettmann, Wiebke, Naik, Marcel, and Budde, Klemens

Subjects
Humans, Kidney Failure, Chronic, Obesity, Weight Loss, Treatment Outcome, Exercise, Perioperative Care, Kidney Transplantation, Living Donors, Waiting Lists, Bariatric Surgery, Renal Insufficiency, Chronic, Muscle Strength, Sarcopenia, Nutrition, Transplantation, Clinical Research, Prevention, Organ Transplantation, Kidney Disease, Stroke, Cancer, Renal and urogenital, Cardiovascular, Oral and gastrointestinal, Metabolic and endocrine, Generic health relevance, epidemiology, kidney transplantation, obesity, obesity paradox, outcome, reverse epidemiology, sarcopenia, sarcopenic obesity, waitlist candidate, Clinical Sciences, Urology & Nephrology
Abstract

Purpose of reviewAlthough a widely recognized and complex pathophysiological condition, sarcopenic obesity remains less appreciated and may elude diagnosis and workup in both kidney transplant waitlisted candidates and kidney transplant recipients. The lack of consensus definition, and practical diagnostic tools for evaluating waitlisted candidates and transplant recipients are barriers to early detect and initiate therapeutic management for sarcopenic obesity. Although sarcopenia leads to poor clinical outcomes, posttransplant obesity yields conflicting results. Exercise and nutritional managements are common therapies for sarcopenic obese patients; however, surgery weight loss or bariatric surgery in both transplant candidates and potential living kidney donors shows promising benefits for kidney transplant access in waitlist obese candidates but may require to be selected for appropriate patients.Recent findingsPathogenesis and management for sarcopenia and obesity are interconnected. The benefits of exercise to improve muscle mass and function is clear in waitlist kidney transplant candidates and transplant recipients. However, there are several barriers for those to increase exercise and improve physical activity including patient, provider, and healthcare or environmental factors. The advantages of fat mass reduction to lose weight can promote muscle mass and strength. However, epidemiological data regarding the obesity paradox in dialysis-dependent patients when overnutrition provides survival benefits for this population should be taken into account when performing weight loss especially bariatric surgery.SummaryBarriers in providing optimal care to kidney transplant waitlisted candidates and transplant recipients may partly result from underdiagnosis of sarcopenic obesity; notwithstanding that this entity has increasingly been more recognized. Mechanistic studies to better understand pathogenesis of sarcopenic obesity will help determine pathogenesis and clinical tools for diagnosis of this entity, which can facilitate further studies related to the outcomes and weight management to ultimately improve kidney transplant outcomes.

Published
2021

30. Recommended Treatment for Antibody-mediated Rejection After Kidney Transplantation: The 2019 Expert Consensus From the Transplantion Society Working Group.

Author

Schinstock, Carrie, Mannon, Roslyn, Budde, Klemens, Chong, Anita, Haas, Mark, Knechtle, Stuart, Lefaucheur, Carmen, Montgomery, Robert, Nickerson, Peter, Tullius, Stefan, Ahn, Curie, Askar, Medhat, Crespo, Marta, Chadban, Steven, Jordan, Stanley, Man, Kwan, Mengel, Michael, Morris, Randall, ODoherty, Inish, Ozdemir, Binnaz, Seron, Daniel, Tambur, Anat, Tanabe, Kazunari, Taupin, Jean-Luc, OConnell, Philip, and Feng, Sandy

Subjects
Antilymphocyte Serum, Consensus, Graft Rejection, Humans, Immunosuppression Therapy, Isoantibodies, Kidney Transplantation, Societies, Medical, Tissue Donors
Abstract

With the development of modern solid-phase assays to detect anti-HLA antibodies and a more precise histological classification, the diagnosis of antibody-mediated rejection (AMR) has become more common and is a major cause of kidney graft loss. Currently, there are no approved therapies and treatment guidelines are based on low-level evidence. The number of prospective randomized trials for the treatment of AMR is small, and the lack of an accepted common standard for care has been an impediment to the development of new therapies. To help alleviate this, The Transplantation Society convened a meeting of international experts to develop a consensus as to what is appropriate treatment for active and chronic active AMR. The aim was to reach a consensus for standard of care treatment against which new therapies could be evaluated. At the meeting, the underlying biology of AMR, the criteria for diagnosis, the clinical phenotypes, and outcomes were discussed. The evidence for different treatments was reviewed, and a consensus for what is acceptable standard of care for the treatment of active and chronic active AMR was presented. While it was agreed that the aims of treatment are to preserve renal function, reduce histological injury, and reduce the titer of donor-specific antibody, there was no conclusive evidence to support any specific therapy. As a result, the treatment recommendations are largely based on expert opinion. It is acknowledged that properly conducted and powered clinical trials of biologically plausible agents are urgently needed to improve patient outcomes.

Published
2020

34. Klinische Entscheidungsfindung mit Künstlicher Intelligenz

Author

Samhammer, David, primary, Beck, Susanne, additional, Budde, Klemens, additional, Burchardt, Aljoscha, additional, Faber, Michelle, additional, Gerndt, Simon, additional, Möller, Sebastian, additional, Osmanodja, Bilgin, additional, Roller, Roland, additional, and Dabrock, Peter, additional

Published
2023
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36. Immunsuppression

Author

Budde, Klemens, Naik, Marcel, Rahmel, Axel, editor, Hahnenkamp, Klaus, editor, and Middel, Claus-Dieter, editor

Published
2022
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37. Results from part A of the multi-center, double-blind, randomized, placebo-controlled NefIgArd trial, which evaluated targeted-release formulation of budesonide for the treatment of primary immunoglobulin A nephropathy

Author

Fragale, Guillermo, Karl, Alejandra, Losisolo, Patricia, Trimarchi, Hernán, Hoyos, Ivan Gonzalez, Lampo, Mauro Guillermo, Monkowski, Matias, De La Fuente, Jorge, Alvarez, Magdalena, Stoppa, Daniela, Chiurchiu, Carlos, Novoa, Pablo Antonio, Orias, Marcelo, Barron, Maria Belen, Giotto, Ana, Arriola, Mariano, Cassini, Evelin, Maldonado, Rafael, Dionisi, Maria Paula, Ryan, Jessica, Toussaint, Nigel, Luxton, Grant, Peh, Chen Au, Levidiotis, Vicki, Francis, Ross, Phoon, Richard, Fedosiuk, Elena, Toropilov, Dmitry, Yakubtsevich, Ruslan, Mikhailova, Elena, Bovy, Christophe, Demoulin, Nathalie, Hougardy, Jean-Michel, Maes, Bart, Speeckaert, Marijn, Laurin, Louis-Philippe, Barbour, Sean, Masse, Melanie, Hladunewich, Michelle, Reich, Heather, Cournoyer, Serge, Tennankore, Karthik, Lv, Jicheng, Liu, Zhangsuo, Wang, Caili, Li, Shaomei, Luo, Qun, Ni, Zhaohui, Yan, Tiekun, Fu, Ping, Cheng, Hong, Liu, Bicheng, Lu, Wanhong, Wang, Jianqin, Chen, Qinkai, Wang, DeGuang, Xiong, Zuying, Chen, Menghua, Xu, Yan, Wei, Jiali, Pai, Pearl, Chen, Lianhua, Rehorova, Jitka, Maixnerova, Dita, Safranek, Roman, Rychlik, Ivan, Hruby, Miroslav, Makela, Satu, Vaaraniemi, Kati, Ortiz, Fernanda, Alamartine, Eric, Daroux, Maite, Cartery, Claire, Vrtovsnik, Francois, Serre, Jean-Emmanuel, Stamellou, Eleni, Vielhauer, Volker, Hugo, Christian, Budde, Klemens, Otte, Britta, Nitschke, Martin, Ntounousi, Evangelia, Boletis, Ioannis, Papagianni, Aikaterini, Goumenos, Dimitrios, Stylianou, Konstantinos, Zermpala, Synodi, Esposito, Ciro, Cozzolino, Mario Gennaro, Viganò, Sara Maria, Gesualdo, Loreto, Nowicki, Michal, Stompor, Tomasz, Kurnatowska, Ilona, Kim, Sung Gyun, Kim, Yong-Lim, Na, Ki-Ryang, Kim, Dong Ki, Kim, Su-Hyun, Porras, Luis Quintana, Garcia, Eva Rodriguez, Pamplona, Irene Agraz, Segarra, Alfons, Goicoechea, Marian, Fellstrom, Bengt, Lundberg, Sigrid, Hemmingsson, Peter, Guron, Gregor, Sandell, Anna, Chen, Cheng-Hsu, Tokgoz, Bulent, Duman, Soner, Altiparmak, Mehmet Riza, Ergul, Metin, Maxwell, Peter, Mark, Patrick, McCafferty, Kieran, Khwaja, Arif, Cheung, Chee Kay, Hall, Matthew, Power, Albert, Kanigicherla, Durga, Baker, Richard, Moriarty, Jim, Mohamed, Amr, Aiello, Joseph, Canetta, Pietro, Ayoub, Isabelle, Robinson, Derrick, Thakar, Surabhi, Mottl, Amy, Sachmechi, Isaac, Fischbach, Bernard, Singh, Harmeet, Mulhern, Jeffrey, Kamal, Fahmeedah, Linfert, Douglas, Rizk, Dana, Wadhwani, Shikha, Sarav, Menaka, Campbell, Kirk, Coppock, Gaia, Luciano, Randy, Sedor, John, Avasare, Rupali, Lau, Wai Lang, Barratt, Jonathan, Lafayette, Richard, Kristensen, Jens, Stone, Andrew, Cattran, Daniel, Floege, Jürgen, Tesar, Vladimir, Zhang, Hong, Eren, Necmi, Paliege, Alexander, and Rovin, Brad H.

Published
2023
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39. Body Mass Index Thresholds and the Use of Bariatric Surgery in the Field of Kidney Transplantation in Germany

Author

Dziodzio, Tomasz, Hillebrandt, Karl Herbert, Knitter, Sebastian, Nösser, Maximilian, Globke, Brigitta, Ritschl, Paul Viktor, Biebl, Matthias, Denecke, Christian, Raakow, Jonas, Lurje, Georg, Schöning, Wenzel, Schmelzle, Moritz, Kahl, Andreas, Fütterer, Markus, Budde, Klemens, Eckardt, Kai-Uwe, Halleck, Fabian, Pratschke, Johann, and Öllinger, Robert

Published
2022
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40. Safety, tolerability, and efficacy of monoclonal CD38 antibody felzartamab in late antibody-mediated renal allograft rejection: study protocol for a phase 2 trial

Author

Mayer, Katharina A., Budde, Klemens, Halloran, Philip F., Doberer, Konstantin, Rostaing, Lionel, Eskandary, Farsad, Christamentl, Anna, Wahrmann, Markus, Regele, Heinz, Schranz, Sabine, Ely, Sarah, Firbas, Christa, Schörgenhofer, Christian, Kainz, Alexander, Loupy, Alexandre, Härtle, Stefan, Boxhammer, Rainer, Jilma, Bernd, and Böhmig, Georg A.

Published
2022
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41. Results of the prospective multicenter SoLKiD cohort study indicate bio-psycho-social outcome risks to kidney donors 12 months after donation

Author

Koch, Martina, Kröncke, Sylvia, Weimer, Rolf, Rainer, Lucy, Sommerer, Claudia, Zeier, Martin, Budde, Klemens, Halleck, Fabian, Ivens, Katrin, Hansen, Anita, Reinke, Petra, Pascher, Andreas, Mühlfeld, Anja, Floege, Jürgen, Wahba, Roger, Vitinius, Frank, Kribben, Andreas, Eisenberger, Ute, Hugo, Christian, Quick, Carmen, Nitschke, Martin, Derad, Inge, Rath, Thomas, Mönch, Christian, Schiffer, Mario, Güler, Faikal, Krüger, Bernd, Bönnighoff, Roderich, Hauser, Ingeborg, Platschek, Steffen, Lopau, Kai, Pein, Ulrich, Weigand, Karl, Feldkamp, Thorsten, Kunzendorf, Ulrich, Suwelack, Barbara, Berger, Klaus, Wolters, Heiner, Gerß, Joachim W.O., Bormann, Eike, Wörmann, Viktorya, and Burgmer, Markus

Published
2022
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42. Office or home versus 24-h blood pressure measurement in stable kidney transplant recipients.

Author

Eleftheriadis, Georgios, Naik, Marcel G, Osmanodja, Bilgin, Halleck, Fabian, Schrezenmeier, Eva, Liefeldt, Lutz, Choi, Mira, Bachmann, Friederike, Avaniadi, Despina Parthenopi, Hoerschelmann, Ellen von, Lücht, Christian, Zaks, Marina, Duettmann, Wiebke, and Budde, Klemens

Subjects
AMBULATORY blood pressure monitoring, PEARSON correlation (Statistics), MEDICAL offices, BLOOD pressure measurement, BLOOD pressure
Abstract

Background The aim of this study was to quantify hypertension control and evaluate concordance between all commonly available blood pressure (BP) modalities in kidney transplant recipients (KTRs). Methods For this prospective cross-sectional study, 89 stable KTRs were recruited at the Charité Transplant Outpatient Clinic. For each study participant office [manual office BP (MOBP) and automated office BP (AOBP)], 7-day home (HBPM) and 24-hour ambulatory BP (24h-ABPM) measurements were performed. Results 80 of the 89 patients recruited had sufficient BP recordings. The mean BP for MOBP, AOBP, HBPM and 24h-ABPM was 129/73, 126/71, 131/85 and 130/81 mmHg, respectively. Uncontrolled hypertension, as defined by 24h-ABPM (mean ≥130/80 mmHg), was present in 53 (66%) patients. MOBP, AOBP and HBPM classified 19 (24%), 22 (28%) and 41 (51%) patients, respectively, as 'uncontrolled hypertensive'. The Bland–Altman plot showed good agreement between systolic MOBP, AOBP, HBPM and daytime-ABPM (mean bias: −1 ± 13 mmHg, −4 ± 13 mmHg, 1 ± 10 mmHg, respectively). Uncontrolled night-time hypertension was present in 74 (93%) KTRs, with 71 (89%) patients showing a non-physiological dipping pattern. Moderate positive correlation between daytime-ABPM/HBPM and night-time-ABPM (Pearson correlation coefficients: 0.62–0.73), followed by MOBP/AOBP (Pearson correlation coefficients: 0.49–0.59) was noted. Estimated eGFR and proteinuria displayed weak correlation with 24h-, daytime- and night-time-ABPM (absolute values of Pearson correlation coefficients: 0.04–0.41). No robust association with either 24h-, daytime- or night-time-ABPM was observed for volume status exams. Conclusions Masked hypertension is highly prevalent in KTRs, especially due to high rates of uncontrolled night-time hypertension. HBPM shows the narrowest limits of agreement with daytime-ABPM. Daytime-ABPM and HBPM show the highest, albeit clinically insufficient, correlation with night-time-ABPM. Systematic integration of 24h-ABPM into clinical practice, as proposed by the 2023 ESH guidelines for the management of arterial hypertension, should not be withheld for the KTR population. Clinical trials evaluating the treatment of hypertension in KTRs are urgently needed. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Risk Stratification Before Living Donor Kidney Transplantation in Patients With Preformed Donor-specific Antibodies by Different Crossmatch Methods.

Author

Ziemann, Malte, Lindemann, Monika, Hallensleben, Michael, Altermann, Wolfgang, Althaus, Karina, Budde, Klemens, Einecke, Gunilla, Eisenberger, Ute, Ender, Andrea, Feldkamp, Thorsten, Grahammer, Florian, Guthoff, Martina, Holzmann-Littig, Christopher, Hugo, Christian, Kauke, Teresa, Kemmner, Stephan, Koch, Martina, Lachmann, Nils, Marget, Matthias, and Morath, Christian

Published
2024
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46. Aspect-Based Passage Retrieval with Contextualized Discourse Vectors

Author

Papaioannou, Jens-Michalis, Mayrdorfer, Manuel, Arnold, Sebastian, Gers, Felix A., Budde, Klemens, Löser, Alexander, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Hiemstra, Djoerd, editor, Moens, Marie-Francine, editor, Mothe, Josiane, editor, Perego, Raffaele, editor, Potthast, Martin, editor, and Sebastiani, Fabrizio, editor

Published
2021
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47. A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection

Author

Mayer, Katharina A., primary, Schrezenmeier, Eva, additional, Diebold, Matthias, additional, Halloran, Philip F., additional, Schatzl, Martina, additional, Schranz, Sabine, additional, Haindl, Susanne, additional, Kasbohm, Silke, additional, Kainz, Alexander, additional, Eskandary, Farsad, additional, Doberer, Konstantin, additional, Patel, Uptal D., additional, Dudani, Jaideep S., additional, Regele, Heinz, additional, Kozakowski, Nicolas, additional, Kläger, Johannes, additional, Boxhammer, Rainer, additional, Amann, Kerstin, additional, Puchhammer-Stöckl, Elisabeth, additional, Vietzen, Hannes, additional, Beck, Julia, additional, Schütz, Ekkehard, additional, Akifova, Aylin, additional, Firbas, Christa, additional, Gilbert, Houston N., additional, Osmanodja, Bilgin, additional, Halleck, Fabian, additional, Jilma, Bernd, additional, Budde, Klemens, additional, and Böhmig, Georg A., additional

Published
2024
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49. #1658 Association of blood dd-cfDNA levels with Banff scores and histopathological lesions in kidney allograft biopsies: results from an observational trial

Author

Akifova, Aylin, primary, Osmanodja, Bilgin, additional, Budde, Klemens, additional, Choi, Mira, additional, Halleck, Fabian, additional, Schrezenmeier, Eva, additional, Beck, Julia, additional, Bornemann-Kolatzki, Kirsten, additional, Schütz, Ekkehard, additional, and Oellerich, Michael, additional

Published
2024
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