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2. (201) Genetic and environment influences on pain, sleep, and depression symptoms in a community sample of twins

Author

Gasperi, M, Herbert, M, Schur, E, Buchwald, D, and Afari, N

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Biological Psychology, Psychology, Behavioral and Social Science, Chronic Pain, Sleep Research, Neurosciences, Mental Health, Brain Disorders, Genetics, Depression, Pain Research, Adult, Aged, Environment, Female, Humans, Male, Middle Aged, Pain, Registries, Sleep Wake Disorders, Young Adult, Clinical Research, Mental health, depression, genetics, pain, sleep, twins, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology
Abstract

We used quantitative genetic methods to evaluate whether sleep quality, pain, and depression symptoms share a common genetic diathesis, to estimate the genetic and environmental sources of covariance among these symptoms, and to test for possible causal relationships.A community sample of 400 twins from the University of Washington Twin Registry completed standardized self-report questionnaires. We used biometric modeling to assess genetic and environmental contribution to the association between sleep quality measured by the Pittsburgh Sleep Quality Index (PSQI), pain measured by the Brief Pain Inventory (BPI), and depression symptoms measured by the Brief Symptom Inventory (BSI-dep). Trivariate Cholesky structural equation models were used to decompose correlations among the phenotypes.Heritability was estimated at 37% (95% CI: 20, 51%) for sleep quality, 25% (9, 41%) for pain, and 39% (22, 53%) for depression. Non-shared environmental influences accounted for the remaining variance. The genetic correlation between sleep quality and pain was rg = 0.69 (95%CI: 0.33, 0.97), rg = 0.56 (0.55, 0.98) between pain and depression, and rg = 0.61 (0.44, 0.88) between depression and sleep quality. Non-shared environmental overlap was present between pain and sleep quality and depression and sleep quality.The link between sleep quality, pain, and depression was primarily explained by shared genetic influences. The genetic factors influencing sleep quality and pain were highly correlated even when accounting for depression. Findings support the hypothesis of a genetic link between sleep quality and pain and potential causality for the association of sleep quality with pain and depression.

Published
2016

5. New Collaborative Research on Suicide Prevention, Practice, and Policy With American Indian and Alaska Native Communities Holds Promise for All Peoples

Author

Barlow, A., primary, Haroz, E. E., additional, O’Keefe, V. M., additional, Brockie, T., additional, Manson, S. M., additional, Allen, J., additional, Wexler, L., additional, Buchwald, D., additional, Rasmus, S., additional, Goklish, N., additional, Ivanich, J., additional, Stifter, M., additional, and Cwik, M., additional

Published
2023
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8. Changing genetic architecture of body mass index from infancy to early adulthood: an individual based pooled analysis of 25 twin cohorts

Author

Silventoinen, K, Li, W, Jelenkovic, A, Sund, R, Yokoyama, Y, Aaltonen, S, Piirtola, M, Sugawara, M, Tanaka, M, Matsumoto, S, Baker, LA, Tuvblad, C, Tynelius, P, Rasmussen, F, Craig, JM, Saffery, R, Willemsen, G, Bartels, M, van Beijsterveldt, CEM, Martin, NG, Medland, SE, Montgomery, GW, Lichtenstein, P, Krueger, RF, McGue, M, Pahlen, S, Christensen, K, Skytthe, A, Kyvik, KO, Saudino, KJ, Dubois, L, Boivin, M, Brendgen, M, Dionne, G, Vitaro, F, Ullemar, V, Almqvist, C, Magnusson, PKE, Corley, RP, Huibregtse, BM, Knafo-Noam, A, Mankuta, D, Abramson, L, Haworth, CMA, Plomin, R, Bjerregaard-Andersen, M, Beck-Nielsen, H, Sodemann, M, Duncan, GE, Buchwald, D, Burt, SA, Klump, KL, Llewellyn, CH, Fisher, A, Boomsma, D, Sorensen, TIA, Kaprio, J, Silventoinen, K, Li, W, Jelenkovic, A, Sund, R, Yokoyama, Y, Aaltonen, S, Piirtola, M, Sugawara, M, Tanaka, M, Matsumoto, S, Baker, LA, Tuvblad, C, Tynelius, P, Rasmussen, F, Craig, JM, Saffery, R, Willemsen, G, Bartels, M, van Beijsterveldt, CEM, Martin, NG, Medland, SE, Montgomery, GW, Lichtenstein, P, Krueger, RF, McGue, M, Pahlen, S, Christensen, K, Skytthe, A, Kyvik, KO, Saudino, KJ, Dubois, L, Boivin, M, Brendgen, M, Dionne, G, Vitaro, F, Ullemar, V, Almqvist, C, Magnusson, PKE, Corley, RP, Huibregtse, BM, Knafo-Noam, A, Mankuta, D, Abramson, L, Haworth, CMA, Plomin, R, Bjerregaard-Andersen, M, Beck-Nielsen, H, Sodemann, M, Duncan, GE, Buchwald, D, Burt, SA, Klump, KL, Llewellyn, CH, Fisher, A, Boomsma, D, Sorensen, TIA, and Kaprio, J

Abstract

BACKGROUND: Body mass index (BMI) shows strong continuity over childhood and adolescence and high childhood BMI is the strongest predictor of adult obesity. Genetic factors strongly contribute to this continuity, but it is still poorly known how their contribution changes over childhood and adolescence. Thus, we used the genetic twin design to estimate the genetic correlations of BMI from infancy to adulthood and compared them to the genetic correlations of height. METHODS: We pooled individual level data from 25 longitudinal twin cohorts including 38,530 complete twin pairs and having 283,766 longitudinal height and weight measures. The data were analyzed using Cholesky decomposition offering genetic and environmental correlations of BMI and height between all age combinations from 1 to 19 years of age. RESULTS: The genetic correlations of BMI and height were stronger than the trait correlations. For BMI, we found that genetic correlations decreased as the age between the assessments increased, a trend that was especially visible from early to middle childhood. In contrast, for height, the genetic correlations were strong between all ages. Age-to-age correlations between environmental factors shared by co-twins were found for BMI in early childhood but disappeared altogether by middle childhood. For height, shared environmental correlations persisted from infancy to adulthood. CONCLUSIONS: Our results suggest that the genes affecting BMI change over childhood and adolescence leading to decreasing age-to-age genetic correlations. This change is especially visible from early to middle childhood indicating that new genetic factors start to affect BMI in middle childhood. Identifying mediating pathways of these genetic factors can open possibilities for interventions, especially for those children with high genetic predisposition to adult obesity.

Published
2022

9. Notfall- und Intensivmedizin/Anästhesiologie

Author

Post, S., Buchwald, A. B., Buchwald, D., Ludwig, H. C., Brüssel, T., Welte, M., Scharrer, I., Kirchmaier, C., Rathgeber, med. J., Burchardi, H., Schreiber, H.-L., Eisenbart, B., Sefrin, P., Ulsenheimer, Klaus, Linares, T., Schmucker, P., Schramm, W., Spannagl, M., Diefenbach, C., Martin, E., Metzger, M., Schiffner, Helga, Kilger, E., Ritter, M. M., and Hiddemann, Wolfgang, editor

Published
2000
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16. Long COVID and Post-infective Fatigue Syndrome: A Review

Author

Sandler, C.X., Wyller, V.B.B., Moss-Morris, R., Buchwald, D., Crawley, E., Hautvast, J.L.A., Katz, B.Z., Knoop, H., Little, P., Taylor, R., Wensaas, K.A., Lloyd, A.R., Sandler, C.X., Wyller, V.B.B., Moss-Morris, R., Buchwald, D., Crawley, E., Hautvast, J.L.A., Katz, B.Z., Knoop, H., Little, P., Taylor, R., Wensaas, K.A., and Lloyd, A.R.

Abstract

Contains fulltext : 245464.pdf (Publisher’s version ) (Open Access), Fatigue is a dominant feature of both acute and convalescent coronavirus disease 2019 (COVID-19) (sometimes termed "long-COVID"), with up to 46% of patients reporting fatigue that lasts from weeks to months. The investigators of the international Collaborative on Fatigue Following Infection (COFFI) conducted a systematic review of post-COVID fatigue and a narrative review on fatigue after other infections, and made recommendations for clinical and research approaches to assessing fatigue after COVID-19. In the majority of COVID-19 cohort studies, persistent fatigue was reported by a significant minority of patients, ranging from 13% to 33% at 16-20 weeks post-symptom onset. Data from the prospective cohort studies in COFFI and others indicate that fatigue is also a prevalent outcome from many acute systemic infections, notably infectious mononucleosis, with a case rate for clinically significant Post-infective fatigue after exclusion of recognized medical and psychiatric causes, ranging from 10%-35% at 6 months. To better characterize post-COVID fatigue, the COFFI investigators recommend the following: application of validated screening questionnaires for case detection; standardized interviews encompassing fatigue, mood, and other symptoms; and investigative approaches to identify end-organ damage and mental health conditions.

Published
2021

17. The Incidence of Stroke in Indigenous Populations of Countries With a Very High Human Development Index: A Systematic Review Protocol.

Author

Balabanski A.H., Dos Santos A., Woods J.A., Thrift A.G., Kleinig T.J., Suchy-Dicey A., Siri S.R., Boden-Albala B., Krishnamurthi R., Feigin V.L., Buchwald D., Ranta A., Mienna C.S., Zavaleta C., Churilov L., Burchill L., Zion D., Longstreth W.T., Tirschwell D.L., Anand S., Parsons M.W., Brown A., Warne D.K., Harwood M., Katzenellenbogen J.M., Balabanski A.H., Dos Santos A., Woods J.A., Thrift A.G., Kleinig T.J., Suchy-Dicey A., Siri S.R., Boden-Albala B., Krishnamurthi R., Feigin V.L., Buchwald D., Ranta A., Mienna C.S., Zavaleta C., Churilov L., Burchill L., Zion D., Longstreth W.T., Tirschwell D.L., Anand S., Parsons M.W., Brown A., Warne D.K., Harwood M., and Katzenellenbogen J.M.

Abstract

Background and Aims: Despite known Indigenous health and socioeconomic disadvantage in countries with a Very High Human Development Index, data on the incidence of stroke in these populations are sparse. With oversight from an Indigenous Advisory Board, we will undertake a systematic review of the incidence of stroke in Indigenous populations of developed countries or regions, with comparisons between Indigenous and non-Indigenous populations of the same region, though not between different Indigenous populations. Method(s): Using PubMed, OVID-EMBASE, and Global Health databases, we will examine population-based incidence studies of stroke in Indigenous adult populations of developed countries published 1990-current, without language restriction. Non-peer-reviewed sources, studies including <10 Indigenous People, or with insufficient data to determine incidence, will be excluded. Two reviewers will independently validate the search strategies, screen titles and abstracts, and record reasons for rejection. Relevant articles will undergo full-text screening, with standard data extracted for all studies included. Quality assessment will include Sudlow and Warlow's criteria for population-based stroke incidence studies, the Newcastle-Ottawa Scale for risk of bias, and the CONSIDER checklist for Indigenous research. Result(s): Primary outcomes include crude, age-specific and/or age-standardized incidence of stroke. Secondary outcomes include overall stroke rates, incidence rate ratio and case-fatality. Results will be synthesized in figures and tables, describing data sources, populations, methodology, and findings. Within-population meta-analysis will be performed if, and where, methodologically sound and comparable studies allow this. Conclusion(s): We will undertake the first systematic review assessing disparities in stroke incidence in Indigenous populations of developed countries. Data outputs will be disseminated to relevant Indigenous stakeholders to inform publi

Published
2021

18. The Incidence of Stroke in Indigenous Populations of Countries With a Very High Human Development Index: A Systematic Review Protocol

Author

Balabanski, AH, Dos Santos, A, Woods, JA, Thrift, AG, Kleinig, TJ, Suchy-Dicey, A, Siri, SR, Boden-Albala, B, Krishnamurthi, R, Feigin, VL, Buchwald, D, Ranta, A, Mienna, CS, Zavaleta, C, Churilov, L, Burchill, L, Zion, D, Longstreth, WT, Tirschwell, DL, Anand, S, Parsons, MW, Brown, A, Warne, DK, Harwood, M, Katzenellenbogen, JM, Balabanski, AH, Dos Santos, A, Woods, JA, Thrift, AG, Kleinig, TJ, Suchy-Dicey, A, Siri, SR, Boden-Albala, B, Krishnamurthi, R, Feigin, VL, Buchwald, D, Ranta, A, Mienna, CS, Zavaleta, C, Churilov, L, Burchill, L, Zion, D, Longstreth, WT, Tirschwell, DL, Anand, S, Parsons, MW, Brown, A, Warne, DK, Harwood, M, and Katzenellenbogen, JM

Abstract

Background and Aims: Despite known Indigenous health and socioeconomic disadvantage in countries with a Very High Human Development Index, data on the incidence of stroke in these populations are sparse. With oversight from an Indigenous Advisory Board, we will undertake a systematic review of the incidence of stroke in Indigenous populations of developed countries or regions, with comparisons between Indigenous and non-Indigenous populations of the same region, though not between different Indigenous populations. Methods: Using PubMed, OVID-EMBASE, and Global Health databases, we will examine population-based incidence studies of stroke in Indigenous adult populations of developed countries published 1990-current, without language restriction. Non-peer-reviewed sources, studies including <10 Indigenous People, or with insufficient data to determine incidence, will be excluded. Two reviewers will independently validate the search strategies, screen titles and abstracts, and record reasons for rejection. Relevant articles will undergo full-text screening, with standard data extracted for all studies included. Quality assessment will include Sudlow and Warlow's criteria for population-based stroke incidence studies, the Newcastle-Ottawa Scale for risk of bias, and the CONSIDER checklist for Indigenous research. Results: Primary outcomes include crude, age-specific and/or age-standardized incidence of stroke. Secondary outcomes include overall stroke rates, incidence rate ratio and case-fatality. Results will be synthesized in figures and tables, describing data sources, populations, methodology, and findings. Within-population meta-analysis will be performed if, and where, methodologically sound and comparable studies allow this. Conclusion: We will undertake the first systematic review assessing disparities in stroke incidence in Indigenous populations of developed countries. Data outputs will be disseminated to relevant Indigenous stakeholders to inform public healt

Published
2021

21. Genetic and environmental variation in educational attainment: an individual-based analysis of 28 twin cohorts

Author

Silventoinen, K, Jelenkovic, A, Sund, R, Latvala, A, Honda, C, Inui, F, Tomizawa, R, Watanabe, M, Sakai, N, Rebato, E, Busjahn, A, Tyler, J, Hopper, JL, Ordonana, JR, Sanchez-Romera, JF, Colodro-Conde, L, Calais-Ferreira, L, Oliveira, VC, Ferreira, PH, Medda, E, Nistico, L, Toccaceli, V, Derom, CA, Vlietinck, RF, Loos, RJF, Siribaddana, SH, Hotopf, M, Sumathipala, A, Rijsdijk, F, Duncan, GE, Buchwald, D, Tynelius, P, Rasmussen, F, Tan, Q, Zhang, D, Pang, Z, Magnusson, PKE, Pedersen, NL, Aslan, AKD, Hwang, AE, Mack, TM, Krueger, RF, McGue, M, Pahlen, S, Brandt, I, Nilsen, TS, Harris, JR, Martin, NG, Medland, SE, Montgomery, GW, Willemsen, G, Bartels, M, van Beijsterveldt, CEM, Franz, CE, Kremen, WS, Lyons, MJ, Silberg, JL, Maes, HH, Kandler, C, Nelson, TL, Whitfield, KE, Corley, RP, Huibregtse, BM, Gatz, M, Butler, DA, Tarnoki, AD, Tarnoki, DL, Park, HA, Lee, J, Lee, SJ, Sung, J, Yokoyama, Y, Sorensen, TIA, Boomsma, D, Kaprio, J, Silventoinen, K, Jelenkovic, A, Sund, R, Latvala, A, Honda, C, Inui, F, Tomizawa, R, Watanabe, M, Sakai, N, Rebato, E, Busjahn, A, Tyler, J, Hopper, JL, Ordonana, JR, Sanchez-Romera, JF, Colodro-Conde, L, Calais-Ferreira, L, Oliveira, VC, Ferreira, PH, Medda, E, Nistico, L, Toccaceli, V, Derom, CA, Vlietinck, RF, Loos, RJF, Siribaddana, SH, Hotopf, M, Sumathipala, A, Rijsdijk, F, Duncan, GE, Buchwald, D, Tynelius, P, Rasmussen, F, Tan, Q, Zhang, D, Pang, Z, Magnusson, PKE, Pedersen, NL, Aslan, AKD, Hwang, AE, Mack, TM, Krueger, RF, McGue, M, Pahlen, S, Brandt, I, Nilsen, TS, Harris, JR, Martin, NG, Medland, SE, Montgomery, GW, Willemsen, G, Bartels, M, van Beijsterveldt, CEM, Franz, CE, Kremen, WS, Lyons, MJ, Silberg, JL, Maes, HH, Kandler, C, Nelson, TL, Whitfield, KE, Corley, RP, Huibregtse, BM, Gatz, M, Butler, DA, Tarnoki, AD, Tarnoki, DL, Park, HA, Lee, J, Lee, SJ, Sung, J, Yokoyama, Y, Sorensen, TIA, Boomsma, D, and Kaprio, J

Abstract

We investigated the heritability of educational attainment and how it differed between birth cohorts and cultural-geographic regions. A classical twin design was applied to pooled data from 28 cohorts representing 16 countries and including 193,518 twins with information on educational attainment at 25 years of age or older. Genetic factors explained the major part of individual differences in educational attainment (heritability: a2 = 0.43; 0.41-0.44), but also environmental variation shared by co-twins was substantial (c2 = 0.31; 0.30-0.33). The proportions of educational variation explained by genetic and shared environmental factors did not differ between Europe, North America and Australia, and East Asia. When restricted to twins 30 years or older to confirm finalized education, the heritability was higher in the older cohorts born in 1900-1949 (a2 = 0.44; 0.41-0.46) than in the later cohorts born in 1950-1989 (a2 = 0.38; 0.36-0.40), with a corresponding lower influence of common environmental factors (c2 = 0.31; 0.29-0.33 and c2 = 0.34; 0.32-0.36, respectively). In conclusion, both genetic and environmental factors shared by co-twins have an important influence on individual differences in educational attainment. The effect of genetic factors on educational attainment has decreased from the cohorts born before to those born after the 1950s.

Published
2020

22. The Value of Twins for Health and Medical Research: A Third of a Century of Progress

Author

Craig, JM, Calais-Ferreira, L, Umstad, MP, Buchwald, D, Craig, JM, Calais-Ferreira, L, Umstad, MP, and Buchwald, D

Abstract

In 1984, Hrubec and Robinette published what was arguably the first review of the role of twins in medical research. The authors acknowledged a growing distinction between two categories of twin studies: those aimed at assessing genetic contributions to disease and those aimed at assessing environmental contributions while controlling for genetic variation. They concluded with a brief section on recently founded twin registries that had begun to provide unprecedented access to twins for medical research. Here we offer an overview of the twin research that, in our estimation, best represents the field has progress since 1984. We start by summarizing what we know about twinning. We then focus on the value of twin study designs to differentiate between genetic and environmental influences on health and on emerging applications of twins in multiple areas of medical research. We finish by describing how twin registries and networks are accelerating twin research worldwide.

Published
2020

23. Genetic and environmental variation in educational attainment : an individual-based analysis of 28 twin cohorts

Author

Silventoinen, K., Jelenkovic, A., Sund, R., Latvala, A., Honda, C., Inui, F., Tomizawa, R., Watanabe, M., Sakai, N., Rebato, E., Busjahn, A., Tyler, J., Hopper, J. L., Ordoñana, J. R., Sánchez-Romera, J. F., Colodro-Conde, L., Calais-Ferreira, L., Oliveira, V. C., Ferreira, P. H., Medda, E., Nisticò, L., Toccaceli, V., Derom, C. A., Vlietinck, R. F., Loos, R. J. F., Siribaddana, S. H., Hotopf, M., Sumathipala, A., Rijsdijk, F., Duncan, G. E., Buchwald, D., Tynelius, P., Rasmussen, F., Tan, Q., Zhang, D., Pang, Z., Magnusson, P. K. E., Pedersen, N. L., Dahl Aslan, Anna K., Hwang, A. E., Mack, T. M., Krueger, R. F., McGue, M., Pahlen, S., Brandt, I., Nilsen, T. S., Harris, J. R., Martin, N. G., Medland, S. E., Montgomery, G. W., Willemsen, G., Bartels, M., van Beijsterveldt, C. E. M., Franz, C. E., Kremen, W. S., Lyons, M. J., Silberg, J. L., Maes, H. H., Kandler, C., Nelson, T. L., Whitfield, K. E., Corley, R. P., Huibregtse, B. M., Gatz, M., Butler, D. A., Tarnoki, A. D., Tarnoki, D. L., Park, H. A., Lee, J., Lee, S. J., Sung, J., Yokoyama, Y., Sørensen, T. I. A., Boomsma, D. I., Kaprio, J., Silventoinen, K., Jelenkovic, A., Sund, R., Latvala, A., Honda, C., Inui, F., Tomizawa, R., Watanabe, M., Sakai, N., Rebato, E., Busjahn, A., Tyler, J., Hopper, J. L., Ordoñana, J. R., Sánchez-Romera, J. F., Colodro-Conde, L., Calais-Ferreira, L., Oliveira, V. C., Ferreira, P. H., Medda, E., Nisticò, L., Toccaceli, V., Derom, C. A., Vlietinck, R. F., Loos, R. J. F., Siribaddana, S. H., Hotopf, M., Sumathipala, A., Rijsdijk, F., Duncan, G. E., Buchwald, D., Tynelius, P., Rasmussen, F., Tan, Q., Zhang, D., Pang, Z., Magnusson, P. K. E., Pedersen, N. L., Dahl Aslan, Anna K., Hwang, A. E., Mack, T. M., Krueger, R. F., McGue, M., Pahlen, S., Brandt, I., Nilsen, T. S., Harris, J. R., Martin, N. G., Medland, S. E., Montgomery, G. W., Willemsen, G., Bartels, M., van Beijsterveldt, C. E. M., Franz, C. E., Kremen, W. S., Lyons, M. J., Silberg, J. L., Maes, H. H., Kandler, C., Nelson, T. L., Whitfield, K. E., Corley, R. P., Huibregtse, B. M., Gatz, M., Butler, D. A., Tarnoki, A. D., Tarnoki, D. L., Park, H. A., Lee, J., Lee, S. J., Sung, J., Yokoyama, Y., Sørensen, T. I. A., Boomsma, D. I., and Kaprio, J.

Abstract

We investigated the heritability of educational attainment and how it differed between birth cohorts and cultural–geographic regions. A classical twin design was applied to pooled data from 28 cohorts representing 16 countries and including 193,518 twins with information on educational attainment at 25 years of age or older. Genetic factors explained the major part of individual differences in educational attainment (heritability: a2 = 0.43; 0.41–0.44), but also environmental variation shared by co-twins was substantial (c2 = 0.31; 0.30–0.33). The proportions of educational variation explained by genetic and shared environmental factors did not differ between Europe, North America and Australia, and East Asia. When restricted to twins 30 years or older to confirm finalized education, the heritability was higher in the older cohorts born in 1900–1949 (a2 = 0.44; 0.41–0.46) than in the later cohorts born in 1950–1989 (a2 = 0.38; 0.36–0.40), with a corresponding lower influence of common environmental factors (c2 = 0.31; 0.29–0.33 and c2 = 0.34; 0.32–0.36, respectively). In conclusion, both genetic and environmental factors shared by co-twins have an important influence on individual differences in educational attainment. The effect of genetic factors on educational attainment has decreased from the cohorts born before to those born after the 1950s.

Published
2020
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33. The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins

Author

Silventoinen, K., Jelenkovic, A., Yokoyama, Y., Sund, R., Sugawara, M., Tanaka, M., Matsumoto, S., Bogl, L. H., Freitas, D. L., Maia, J. A., Hjelmborg, J. v. B., Aaltonen, S., Piirtola, M., Latvala, A., Calais-Ferreira, L., Oliveira, V. C., Ferreira, P. H., Ji, F., Ning, F., Pang, Z., Ordonana, J. R., Sanchez-Romera, J. F., Colodro-Conde, L., Burt, S. A., Klump, K. L., Martin, N. G., Medland, S. E., Montgomery, G. W., Kandler, C., McAdams, T. A., Eley, T. C., Gregory, A. M., Saudino, K. J., Dubois, L., Boivin, M., Brendgen, M., Dionne, G., Vitaro, F., Tarnoki, A. D., Tarnoki, D. L., Haworth, C. M. A., Plomin, R., Oncel, S. Y., Aliev, F., Medda, E., Nistico, L., Toccaceli, V., Craig, J. M., Saffery, R., Siribaddana, S. H., Hotopf, M., Sumathipala, A., Rijsdijk, F., Jeong, H. -U., Spector, T., Mangino, M., Lachance, G., Gatz, M., Butler, D. A., Gao, W., Yu, C., Li, L., Bayasgalan, G., Narandalai, D., Harden, K. P., Tucker-Drob, E. M., Christensen, K., Skytthe, A., Kyvik, K. O., Derom, C. A., Vlietinck, R. F., Loos, R. J. F., Cozen, W., Hwang, A. E., Mack, T. M., He, M., Ding, X., Silberg, J. L., Maes, H. H., Cutler, T. L., Hopper, J. L., Magnusson, P. K. E., Pedersen, N. L., Dahl Aslan, A. K., Baker, L. A., Tuvblad, C., Bjerregaard-Andersen, M., Beck-Nielsen, H., Sodemann, M., Ullemar, V., Almqvist, C., Tan, Q., Zhang, D., Swan, G. E., Krasnow, R., Jang, K. L., Knafo-Noam, A., Mankuta, D., Abramson, L., Lichtenstein, P., Krueger, R. F., McGue, M., Pahlen, S., Tynelius, P., Rasmussen, F., Duncan, G. E., Buchwald, D., Corley, R. P., Huibregtse, B. M., Nelson, T. L., Whitfield, K. E., Franz, C. E., Kremen, W. S., Lyons, M. J., Ooki, S., Brandt, I., Nilsen, T. S., Harris, J. R., Sung, J., Park, H. A., Lee, J., Lee, S. J., Willemsen, G., Bartels, M., Van Beijsterveldt, C. E. M., Llewellyn, C. H., Fisher, A., Rebato, E., Busjahn, A., Tomizawa, R., Inui, F., Watanabe, M., Honda, C., Sakai, N., Hur, Y. -M., Sørensen, T. I. A., Boomsma, D. I., Kaprio, J., Silventoinen, K., Jelenkovic, A., Yokoyama, Y., Sund, R., Sugawara, M., Tanaka, M., Matsumoto, S., Bogl, L. H., Freitas, D. L., Maia, J. A., Hjelmborg, J. v. B., Aaltonen, S., Piirtola, M., Latvala, A., Calais-Ferreira, L., Oliveira, V. C., Ferreira, P. H., Ji, F., Ning, F., Pang, Z., Ordonana, J. R., Sanchez-Romera, J. F., Colodro-Conde, L., Burt, S. A., Klump, K. L., Martin, N. G., Medland, S. E., Montgomery, G. W., Kandler, C., McAdams, T. A., Eley, T. C., Gregory, A. M., Saudino, K. J., Dubois, L., Boivin, M., Brendgen, M., Dionne, G., Vitaro, F., Tarnoki, A. D., Tarnoki, D. L., Haworth, C. M. A., Plomin, R., Oncel, S. Y., Aliev, F., Medda, E., Nistico, L., Toccaceli, V., Craig, J. M., Saffery, R., Siribaddana, S. H., Hotopf, M., Sumathipala, A., Rijsdijk, F., Jeong, H. -U., Spector, T., Mangino, M., Lachance, G., Gatz, M., Butler, D. A., Gao, W., Yu, C., Li, L., Bayasgalan, G., Narandalai, D., Harden, K. P., Tucker-Drob, E. M., Christensen, K., Skytthe, A., Kyvik, K. O., Derom, C. A., Vlietinck, R. F., Loos, R. J. F., Cozen, W., Hwang, A. E., Mack, T. M., He, M., Ding, X., Silberg, J. L., Maes, H. H., Cutler, T. L., Hopper, J. L., Magnusson, P. K. E., Pedersen, N. L., Dahl Aslan, A. K., Baker, L. A., Tuvblad, C., Bjerregaard-Andersen, M., Beck-Nielsen, H., Sodemann, M., Ullemar, V., Almqvist, C., Tan, Q., Zhang, D., Swan, G. E., Krasnow, R., Jang, K. L., Knafo-Noam, A., Mankuta, D., Abramson, L., Lichtenstein, P., Krueger, R. F., McGue, M., Pahlen, S., Tynelius, P., Rasmussen, F., Duncan, G. E., Buchwald, D., Corley, R. P., Huibregtse, B. M., Nelson, T. L., Whitfield, K. E., Franz, C. E., Kremen, W. S., Lyons, M. J., Ooki, S., Brandt, I., Nilsen, T. S., Harris, J. R., Sung, J., Park, H. A., Lee, J., Lee, S. J., Willemsen, G., Bartels, M., Van Beijsterveldt, C. E. M., Llewellyn, C. H., Fisher, A., Rebato, E., Busjahn, A., Tomizawa, R., Inui, F., Watanabe, M., Honda, C., Sakai, N., Hur, Y. -M., Sørensen, T. I. A., Boomsma, D. I., and Kaprio, J.

Published
2019

34. The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins

Author

Silventoinen, K, Jelenkovic, A, Yokoyama, Y, Sund, R, Sugawara, M, Tanaka, M, Matsumoto, S, Bogl, L H, Freitas, D L, Maia, J A, Hjelmborg, J V B, Aaltonen, S, Piirtola, M, Latvala, A, Calais-Ferreira, L, Oliveira, V C, Ferreira, P H, Ji, F, Ning, F, Pang, Z, Ordoñana, J R, Sánchez-Romera, J F, Colodro-Conde, L, Burt, S A, Klump, K L, Martin, N G, Medland, S E, Montgomery, G W, Kandler, C, McAdams, T A, Eley, T C, Gregory, A M, Saudino, K J, Dubois, L, Boivin, M, Brendgen, M, Dionne, G, Vitaro, F, Tarnoki, A D, Tarnoki, D L, Haworth, C M A, Plomin, R, Öncel, S Y, Aliev, F, Medda, E, Nisticò, L, Toccaceli, V, Craig, J M, Saffery, R, Siribaddana, S H, Hotopf, M, Sumathipala, A, Rijsdijk, F, Jeong, H-U, Spector, T, Mangino, M, Lachance, G, Gatz, M, Butler, D A, Gao, W, Yu, C, Li, L, Bayasgalan, G, Narandalai, D, Harden, K P, Tucker-Drob, E M, Christensen, K, Skytthe, A, Kyvik, K O, Derom, C A, Vlietinck, R F, Loos, R J F, Cozen, W, Hwang, A E, Mack, T M, He, M, Ding, X, Silberg, J L, Maes, H H, Cutler, T L, Hopper, J L, Magnusson, P K E, Pedersen, N L, Dahl Aslan, A K, Baker, L A, Tuvblad, C, Bjerregaard-Andersen, M, Beck-Nielsen, H, Sodemann, M, Ullemar, V, Almqvist, C, Tan, Q, Zhang, D, Swan, G E, Krasnow, R, Jang, K L, Knafo-Noam, A, Mankuta, D, Abramson, L, Lichtenstein, P, Krueger, R F, McGue, M, Pahlen, S, Tynelius, P, Rasmussen, F, Duncan, G E, Buchwald, D, Corley, R P, Huibregtse, B M, Nelson, T L, Whitfield, K E, Franz, C E, Kremen, W S, Lyons, M J, Ooki, S, Brandt, I, Nilsen, T S, Harris, J R, Sung, J, Park, H A, Lee, J, Lee, S J, Willemsen, Gonneke, Bartels, Meike, van Beijsterveldt, C.E.M., Llewellyn, C H, Fisher, A, Rebato, E, Busjahn, A, Tomizawa, R, Inui, F, Watanabe, M, Honda, C, Sakai, N, Hur, Y-M, Sørensen, T I A, Boomsma, D.I., Kaprio, J, Silventoinen, K, Jelenkovic, A, Yokoyama, Y, Sund, R, Sugawara, M, Tanaka, M, Matsumoto, S, Bogl, L H, Freitas, D L, Maia, J A, Hjelmborg, J V B, Aaltonen, S, Piirtola, M, Latvala, A, Calais-Ferreira, L, Oliveira, V C, Ferreira, P H, Ji, F, Ning, F, Pang, Z, Ordoñana, J R, Sánchez-Romera, J F, Colodro-Conde, L, Burt, S A, Klump, K L, Martin, N G, Medland, S E, Montgomery, G W, Kandler, C, McAdams, T A, Eley, T C, Gregory, A M, Saudino, K J, Dubois, L, Boivin, M, Brendgen, M, Dionne, G, Vitaro, F, Tarnoki, A D, Tarnoki, D L, Haworth, C M A, Plomin, R, Öncel, S Y, Aliev, F, Medda, E, Nisticò, L, Toccaceli, V, Craig, J M, Saffery, R, Siribaddana, S H, Hotopf, M, Sumathipala, A, Rijsdijk, F, Jeong, H-U, Spector, T, Mangino, M, Lachance, G, Gatz, M, Butler, D A, Gao, W, Yu, C, Li, L, Bayasgalan, G, Narandalai, D, Harden, K P, Tucker-Drob, E M, Christensen, K, Skytthe, A, Kyvik, K O, Derom, C A, Vlietinck, R F, Loos, R J F, Cozen, W, Hwang, A E, Mack, T M, He, M, Ding, X, Silberg, J L, Maes, H H, Cutler, T L, Hopper, J L, Magnusson, P K E, Pedersen, N L, Dahl Aslan, A K, Baker, L A, Tuvblad, C, Bjerregaard-Andersen, M, Beck-Nielsen, H, Sodemann, M, Ullemar, V, Almqvist, C, Tan, Q, Zhang, D, Swan, G E, Krasnow, R, Jang, K L, Knafo-Noam, A, Mankuta, D, Abramson, L, Lichtenstein, P, Krueger, R F, McGue, M, Pahlen, S, Tynelius, P, Rasmussen, F, Duncan, G E, Buchwald, D, Corley, R P, Huibregtse, B M, Nelson, T L, Whitfield, K E, Franz, C E, Kremen, W S, Lyons, M J, Ooki, S, Brandt, I, Nilsen, T S, Harris, J R, Sung, J, Park, H A, Lee, J, Lee, S J, Willemsen, Gonneke, Bartels, Meike, van Beijsterveldt, C.E.M., Llewellyn, C H, Fisher, A, Rebato, E, Busjahn, A, Tomizawa, R, Inui, F, Watanabe, M, Honda, C, Sakai, N, Hur, Y-M, Sørensen, T I A, Boomsma, D.I., and Kaprio, J

Abstract

The COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) project is a large international collaborative effort to analyze individual-level phenotype data from twins in multiple cohorts from different environments. The main objective is to study factors that modify genetic and environmental variation of height, body mass index (BMI, kg/m2) and size at birth, and additionally to address other research questions such as long-term consequences of birth size. The project started in 2013 and is open to all twin projects in the world having height and weight measures on twins with information on zygosity. Thus far, 54 twin projects from 24 countries have provided individual-level data. The CODATwins database includes 489,981 twin individuals (228,635 complete twin pairs). Since many twin cohorts have collected longitudinal data, there is a total of 1,049,785 height and weight observations. For many cohorts, we also have information on birth weight and length, own smoking behavior and own or parental education. We found that the heritability estimates of height and BMI systematically changed from infancy to old age. Remarkably, only minor differences in the heritability estimates were found across cultural-geographic regions, measurement time and birth cohort for height and BMI. In addition to genetic epidemiological studies, we looked at associations of height and BMI with education, birth weight and smoking status. Within-family analyses examined differences within same-sex and opposite-sex dizygotic twins in birth size and later development. The CODATwins project demonstrates the feasibility and value of international collaboration to address gene-by-exposure interactions that require large sample sizes and address the effects of different exposures across time, geographical regions and socioeconomic status.

Published
2019
Full Text
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42. The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins

Author

Silventoinen, K., primary, Jelenkovic, A., additional, Yokoyama, Y., additional, Sund, R., additional, Sugawara, M., additional, Tanaka, M., additional, Matsumoto, S., additional, Bogl, L. H., additional, Freitas, D. L., additional, Maia, J. A., additional, Hjelmborg, J. v. B., additional, Aaltonen, S., additional, Piirtola, M., additional, Latvala, A., additional, Calais-Ferreira, L., additional, Oliveira, V. C., additional, Ferreira, P. H., additional, Ji, F., additional, Ning, F., additional, Pang, Z., additional, Ordoñana, J. R., additional, Sánchez-Romera, J. F., additional, Colodro-Conde, L., additional, Burt, S. A., additional, Klump, K. L., additional, Martin, N. G., additional, Medland, S. E., additional, Montgomery, G. W., additional, Kandler, C., additional, McAdams, T. A., additional, Eley, T. C., additional, Gregory, A. M., additional, Saudino, K. J., additional, Dubois, L., additional, Boivin, M., additional, Brendgen, M., additional, Dionne, G., additional, Vitaro, F., additional, Tarnoki, A. D., additional, Tarnoki, D. L., additional, Haworth, C. M. A., additional, Plomin, R., additional, Öncel, S. Y., additional, Aliev, F., additional, Medda, E., additional, Nisticò, L., additional, Toccaceli, V., additional, Craig, J. M., additional, Saffery, R., additional, Siribaddana, S. H., additional, Hotopf, M., additional, Sumathipala, A., additional, Rijsdijk, F., additional, Jeong, H.-U., additional, Spector, T., additional, Mangino, M., additional, Lachance, G., additional, Gatz, M., additional, Butler, D. A., additional, Gao, W., additional, Yu, C., additional, Li, L., additional, Bayasgalan, G., additional, Narandalai, D., additional, Harden, K. P., additional, Tucker-Drob, E. M., additional, Christensen, K., additional, Skytthe, A., additional, Kyvik, K. O., additional, Derom, C. A., additional, Vlietinck, R. F., additional, Loos, R. J. F., additional, Cozen, W., additional, Hwang, A. E., additional, Mack, T. M., additional, He, M., additional, Ding, X., additional, Silberg, J. L., additional, Maes, H. H., additional, Cutler, T. L., additional, Hopper, J. L., additional, Magnusson, P. K. E., additional, Pedersen, N. L., additional, Dahl Aslan, A. K., additional, Baker, L. A., additional, Tuvblad, C., additional, Bjerregaard-Andersen, M., additional, Beck-Nielsen, H., additional, Sodemann, M., additional, Ullemar, V., additional, Almqvist, C., additional, Tan, Q., additional, Zhang, D., additional, Swan, G. E., additional, Krasnow, R., additional, Jang, K. L., additional, Knafo-Noam, A., additional, Mankuta, D., additional, Abramson, L., additional, Lichtenstein, P., additional, Krueger, R. F., additional, McGue, M., additional, Pahlen, S., additional, Tynelius, P., additional, Rasmussen, F., additional, Duncan, G. E., additional, Buchwald, D., additional, Corley, R. P., additional, Huibregtse, B. M., additional, Nelson, T. L., additional, Whitfield, K. E., additional, Franz, C. E., additional, Kremen, W. S., additional, Lyons, M. J., additional, Ooki, S., additional, Brandt, I., additional, Nilsen, T. S., additional, Harris, J. R., additional, Sung, J., additional, Park, H. A., additional, Lee, J., additional, Lee, S. J., additional, Willemsen, G., additional, Bartels, M., additional, van Beijsterveldt, C. E. M., additional, Llewellyn, C. H., additional, Fisher, A., additional, Rebato, E., additional, Busjahn, A., additional, Tomizawa, R., additional, Inui, F., additional, Watanabe, M., additional, Honda, C., additional, Sakai, N., additional, Hur, Y.-M., additional, Sørensen, T. I. A., additional, Boomsma, D. I., additional, and Kaprio, J., additional

Published
2019
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