1. Planning a Return to Normal after the COVID-19 Pandemic: Identifying Safe Contact Levels via Online Optimization
- Author
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Bianchin, Gianluca, Dall'Anese, Emiliano, Poveda, Jorge I., Jacobson, David, Carlton, Elizabeth J., and Buchwald, Andrea G.
- Subjects
Mathematics - Optimization and Control ,Electrical Engineering and Systems Science - Systems and Control - Abstract
Since the early months of 2020, non-pharmaceutical interventions (NPIs) -- implemented at varying levels of severity and based on widely-divergent perspectives of risk tolerance -- have been the primary means to control SARS-CoV-2 transmission. We seek to identify how risk tolerance and vaccination rates impact the rate at which a population can return to pre-pandemic contact behavior. To this end, we develop a novel feedback control method for data-driven decision-making to identify optimal levels of NPIs across geographical regions in order to guarantee that hospitalizations will not exceed a given risk tolerance. Results are shown for the state of Colorado, and they suggest that: coordination in decision-making across regions is essential to maintain the daily number of hospitalizations below the desired limits; increasing risk tolerance can decrease the number of days required to discontinue NPIs, at the cost of an increased number of deaths; and if vaccination uptake is less than 70\%, at most levels of risk tolerance, return to pre-pandemic contact behaviors before the early months of 2022 may newly jeopardize the healthcare system., Comment: A preliminary version of this work appeared on medrXiv on April 1, 2021. Available at: https://www.medrxiv.org/content/10.1101/2021.04.20.21255350v1
- Published
- 2021