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1. COVID-19 et transplantation d’organes, les leçons du recensement national de la Société francophone de transplantation

Author

Caillard, S., Moulin, B., Fafi-Kremer, S., Hazzan, M., Anglicheau, D., Hertig, A., Tourret, J., Barrou, B., Morelon, E., Thaunat, O., Couzi, L., Merville, P., Moal, V., Legris, T., Westeel, P.-F., Jaureguy, M., Frimat, L., Ducloux, D., Bamoulid, J., Bertrand, D., Tsimaratos, M., Garaix-Gilardo, F., Dumortier, J., Mussot, S., Roux, A., Sebbag, L., Le Meur, Y., Blancho, G., Masset, C., Kamar, N., Francois, H., Rondeau, E., Bouvier, N., Mousson, C., Buchler, M., Gatault, P., Augusto, J.-F., Duveau, A., Vigneau, C., Morin, M.-C., Chemouny, J., Golbin, L., Grimbert, P., Matignon, M., Durrbach, A., Greze, C., Snanoudj, R., Colosio, C., Schvartz, B., Malvezzi, P., Mariat, C., Thierry, A., Le Quintrec, M., Sicard, A., Rerolle, J.P., Heng, A.-É., Garrouste, C., Coponat, H.V., Epailly, É., Brugiere, O., Dharancy, S., Salame, É., Saliba, F., and Caillard, Sophie

Published
2022
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2. Diagnosis and treatment of pancreatic duct disruption or disconnection: an international expert survey and case vignette study

Author

Albert, J., Arvanitakis, M., Badaoui, A., Barthet, M., van Biervliet, G., Bradley, E., Boermeester, M., Buchler, M., Cappendijk, V., Charnley, R., Connor, S., Dejong, C., Dellinger, P., Dervenis, C., Deviere, J., Dumonceau, J., van Eijck, C., Fagenholz, P., Castillo, C.Fernandez-del, Forsmark, C., Freeman, M., French, J., van Goor, H., Haveman, J.W., van Hooft, J., Hucl, T., Isaji, S., Jagielski, M., Karjula, H., Lerch, M., Lévy, P., Lillemoe, K., Löhr, M., Mayerle, J., Mittal, A., Morgan, D., Moon, S., Nieuwenhuijs, V., Sarr, M., Seewald, S., Sherman, S., Singh, V., Siriwardena, A., Stommel, M., Tann, M., Téllez-Avina, F., Timmer, R., Traverso, W., Radenkovic, D., Rana, S., Rebours, V., Pelaez-Luna, M., Poley, J.W., Windsor, J., Zaheer, A., Zyromski, N., Boxhoorn, Lotte, Timmerhuis, Hester C., Verdonk, Robert C., Besselink, Marc G., Bollen, Thomas L., Bruno, Marco J., Elmunzer, B. Joseph, Fockens, Paul, Horvath, Karen D., van Santvoort, Hjalmar C., and Voermans, Rogier P.

Published
2021
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5. Dispersive Treatment of K --> Pi Pi

Author

Buchler, M.

Subjects
High Energy Physics - Phenomenology
Abstract

We propose a new method to obtain the K -> pi pi amplitude from K -> pi which allows one to fully account for the effects of final state interactions. The method is based on a set of dispersion relations for the K -> pi pi amplitude in which the weak Hamiltonian carries momentum. The soft pion theorem, which relates this amplitude to the K -> pi amplitude, can be used to determine one of the two subtraction constants - the second constant is at present known only to leading order in chiral perturbation theory., Comment: Latex, 4 pages, 1 figure

Published
2002

6. Design and Operation of Front-End Electronics for the HERA-B Muon Detector

Author

Buchler, M., Funk, W., Gutierrez, A., Harr, R. F., Karchin, P. E., Liu, P., Nam, S., Shiu, J. G., Takach, S. F., Atiya, M., Padrazo, D., Arefiev, A., Barsuk, S., Khasanov, F., Laptin, L., Tchoudakov, V., Tichimirov, I., Titov, M., and Zaitsev, Y.

Subjects
Physics - Instrumentation and Detectors
Abstract

We have implemented a cost-effective design for the readout electronics of both the anode wires and the cathode pads of large area proportional wire chambers for the HERA-B muon system based on the ASD-08 integrated circuit. To control and monitor the large number of readout channels, we have built a distributed control system based on Philips Semiconductors' I2C bus and microcontrollers. To date we have installed about 10800 channels of muon chambers and electronics. The average single channel noise occupancy is less than 10**-5, and the detectors have been operated with target interaction rates as high as 70 MHz., Comment: 9 pages, 13 figures; submitted to IEEE Transactions on Nuclear Science; to appear in Conference Record of 1998 IEEE NSS in Toronto

Published
1998
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9. Evidence Map of Pancreatic Surgery–A living systematic review with meta-analyses by the International Study Group of Pancreatic Surgery (ISGPS)

Author

Probst, P, Huttner, F, Meydan, O, Abu Hilal, M, Adham, M, Barreto, S, Besselink, M, Busch, O, Bockhorn, M, Del Chiaro, M, Conlon, K, Castillo, C, Friess, H, Fusai, G, Gianotti, L, Hackert, T, Halloran, C, Izbicki, J, Kalkum, E, Kelemen, D, Kenngott, H, Kretschmer, R, Landre, V, Lillemoe, K, Miao, Y, Marchegiani, G, Mihaljevic, A, Radenkovich, D, Salvia, R, Sandini, M, Serrablo, A, Shrikhande, S, Shukla, P, Siriwardena, A, Strobel, O, Uzunoglu, F, Vollmer, C, Weitz, J, Wolfgang, C, Zerbi, A, Bassi, C, Dervenis, C, Neoptolemos, J, Buchler, M, Diener, M, Probst P., Huttner F. J., Meydan O., Abu Hilal M., Adham M., Barreto S. G., Besselink M. G., Busch O. R., Bockhorn M., Del Chiaro M., Conlon K., Castillo C. F. -D., Friess H., Fusai G. K., Gianotti L., Hackert T., Halloran C., Izbicki J., Kalkum E., Kelemen D., Kenngott H. G., Kretschmer R., Landre V., Lillemoe K. D., Miao Y., Marchegiani G., Mihaljevic A., Radenkovich D., Salvia R., Sandini M., Serrablo A., Shrikhande S., Shukla P. J., Siriwardena A. K., Strobel O., Uzunoglu F. G., Vollmer C., Weitz J., Wolfgang C. L., Zerbi A., Bassi C., Dervenis C., Neoptolemos J., Buchler M. W., Diener M. K., Probst, P, Huttner, F, Meydan, O, Abu Hilal, M, Adham, M, Barreto, S, Besselink, M, Busch, O, Bockhorn, M, Del Chiaro, M, Conlon, K, Castillo, C, Friess, H, Fusai, G, Gianotti, L, Hackert, T, Halloran, C, Izbicki, J, Kalkum, E, Kelemen, D, Kenngott, H, Kretschmer, R, Landre, V, Lillemoe, K, Miao, Y, Marchegiani, G, Mihaljevic, A, Radenkovich, D, Salvia, R, Sandini, M, Serrablo, A, Shrikhande, S, Shukla, P, Siriwardena, A, Strobel, O, Uzunoglu, F, Vollmer, C, Weitz, J, Wolfgang, C, Zerbi, A, Bassi, C, Dervenis, C, Neoptolemos, J, Buchler, M, Diener, M, Probst P., Huttner F. J., Meydan O., Abu Hilal M., Adham M., Barreto S. G., Besselink M. G., Busch O. R., Bockhorn M., Del Chiaro M., Conlon K., Castillo C. F. -D., Friess H., Fusai G. K., Gianotti L., Hackert T., Halloran C., Izbicki J., Kalkum E., Kelemen D., Kenngott H. G., Kretschmer R., Landre V., Lillemoe K. D., Miao Y., Marchegiani G., Mihaljevic A., Radenkovich D., Salvia R., Sandini M., Serrablo A., Shrikhande S., Shukla P. J., Siriwardena A. K., Strobel O., Uzunoglu F. G., Vollmer C., Weitz J., Wolfgang C. L., Zerbi A., Bassi C., Dervenis C., Neoptolemos J., Buchler M. W., and Diener M. K.

Abstract

Background: Pancreatic surgery is associated with considerable morbidity and, consequently, offers a large and complex field for research. To prioritize relevant future scientific projects, it is of utmost importance to identify existing evidence and uncover research gaps. Thus, the aim of this project was to create a systematic and living Evidence Map of Pancreatic Surgery. Methods: PubMed, the Cochrane Central Register of Controlled Trials, and Web of Science were systematically searched for all randomized controlled trials and systematic reviews on pancreatic surgery. Outcomes from every existing randomized controlled trial were extracted, and trial quality was assessed. Systematic reviews were used to identify an absence of randomized controlled trials. Randomized controlled trials and systematic reviews on identical subjects were grouped according to research topics. A web-based evidence map modeled after a mind map was created to visualize existing evidence. Meta-analyses of specific outcomes of pancreatic surgery were performed for all research topics with more than 3 randomized controlled trials. For partial pancreatoduodenectomy and distal pancreatectomy, pooled benchmarks for outcomes were calculated with a 99% confidence interval. The evidence map undergoes regular updates. Results: Out of 30,860 articles reviewed, 328 randomized controlled trials on 35,600 patients and 332 systematic reviews were included and grouped into 76 research topics. Most randomized controlled trials were from Europe (46%) and most systematic reviews were from Asia (51%). A living meta-analysis of 21 out of 76 research topics (28%) was performed and included in the web-based evidence map. Evidence gaps were identified in 11 out of 76 research topics (14%). The benchmark for mortality was 2% (99% confidence interval: 1%–2%) for partial pancreatoduodenectomy and <1% (99% confidence interval: 0%–1%) for distal pancreatectomy. The benchmark for overall complications was 53% (99%co

Published
2021

11. Étude PROspective, Multicentrique, randomisée, en ouvert, évaluant le bénéfice sur la fonction rénale à 12 mois post-transplantation, d’une immunosuppression avec sevrage de l’inhibiteur de la calcineurine à 3 mois et associant mycophénolate sodique-Evérolimus versus Tacrolimus-Evérolimus chez des patients transplantés rénaux de novo

Author

Thierry, A., primary, Anglicheau, D., additional, Buchler, M., additional, Lemoine, M., additional, Ohlmann, S., additional, Colosio, C., additional, Ecotière, L., additional, Touchard, G., additional, Goujon, J.M., additional, and Ragot, S., additional

Published
2022
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12. Standards for reporting on surgery for chronic pancreatitis: a report from the International Study Group for Pancreatic Surgery (ISGPS)

Author

Siriwardena, A, Windsor, J, Zyromski, N, Marchegiani, G, Radenkovic, D, Morgan, C, Passas, I, Olah, A, Conlon, K, Smith, M, Busch, O, Baltatzis, M, Besselink, M, Vollmer, C, Castillo, C, Friess, H, Garcea, G, Burmeister, S, Hackert, T, Lillemoe, K, Schulick, R, Shrikhande, S, Smith, A, Gianotti, L, Falconi, M, Adams, D, Adham, M, Andersson, R, Del Chiaro, M, Devar, J, Jegatheeswaran, S, van Santvoort, H, Khatkov, I, Izbicki, J, Buchler, M, Neoptolemos, J, Bassi, C, Dervenis, C, Siriwardena A. K., Windsor J., Zyromski N., Marchegiani G., Radenkovic D., Morgan C., Passas I., Olah A., Conlon K. C., Smith M., Busch O., Baltatzis M., Besselink M. G., Vollmer C., Castillo C. F. -D., Friess H., Garcea G., Burmeister S., Hackert T., Lillemoe K. D., Schulick R., Shrikhande S. V., Smith A., Gianotti L., Falconi M., Adams D., Adham M., Andersson R., Del Chiaro M., Devar J., Jegatheeswaran S., van Santvoort H., Khatkov I., Izbicki J., Buchler M., Neoptolemos J. P., Bassi C., Dervenis C., Siriwardena, A, Windsor, J, Zyromski, N, Marchegiani, G, Radenkovic, D, Morgan, C, Passas, I, Olah, A, Conlon, K, Smith, M, Busch, O, Baltatzis, M, Besselink, M, Vollmer, C, Castillo, C, Friess, H, Garcea, G, Burmeister, S, Hackert, T, Lillemoe, K, Schulick, R, Shrikhande, S, Smith, A, Gianotti, L, Falconi, M, Adams, D, Adham, M, Andersson, R, Del Chiaro, M, Devar, J, Jegatheeswaran, S, van Santvoort, H, Khatkov, I, Izbicki, J, Buchler, M, Neoptolemos, J, Bassi, C, Dervenis, C, Siriwardena A. K., Windsor J., Zyromski N., Marchegiani G., Radenkovic D., Morgan C., Passas I., Olah A., Conlon K. C., Smith M., Busch O., Baltatzis M., Besselink M. G., Vollmer C., Castillo C. F. -D., Friess H., Garcea G., Burmeister S., Hackert T., Lillemoe K. D., Schulick R., Shrikhande S. V., Smith A., Gianotti L., Falconi M., Adams D., Adham M., Andersson R., Del Chiaro M., Devar J., Jegatheeswaran S., van Santvoort H., Khatkov I., Izbicki J., Buchler M., Neoptolemos J. P., Bassi C., and Dervenis C.

Abstract

Background: The International Study Group for Pancreatic Surgery provides globally accepted definitions for reporting of complications after pancreatic surgery. This International Study Group for Pancreatic Surgery project aims to provide a standardized framework for reporting of the results of operative treatment for chronic pancreatitis. Methods: An International Study Group for Pancreatic Surgery project circulation list was created with pre-existing and new members and including gastroenterologists in addition to surgeons. A computerized search of the literature was undertaken for articles reporting the operative treatment of chronic pancreatitis. The results of the literature search were presented at the first face-to-face meeting of this International Study Group for Pancreatic Surgery project group. A document outlining proposed reporting standards was produced by discussion during an initial meeting of the International Study Group for Pancreatic Surgery. An electronic questionnaire was then sent to all current members of the International Study Group for Pancreatic Surgery. Responses were collated and further discussed at international meetings in North America, Europe, and at the International Association of Pancreatology World Congress in 2019. A final consensus document was produced by integration of multiple iterations. Results: The International Study Group for Pancreatic Surgery consensus standards for reporting of surgery in chronic pancreatitis recommends 4 core domains and the necessary variables needed for reporting of results: clinical baseline before operation; the morphology of the diseased gland; a new, standardized, operative terminology; and a minimum outcome dataset. The 4 domains combine to give a comprehensive framework for reports. Conclusion: Adoption of the 4 domains of the International Study Group for Pancreatic Surgery reporting standards for surgery for chronic pancreatitis will facilitate comparison of results between centers and

Published
2020

13. Management of the pancreatic transection plane after left (distal) pancreatectomy: Expert consensus guidelines by the International Study Group of Pancreatic Surgery (ISGPS)

Author

Miao, Y, Lu, Z, Yeo, C, Vollmer, C, Fernandez-del Castillo, C, Ghaneh, P, Halloran, C, Kleeff, J, de Rooij, T, Werner, J, Falconi, M, Friess, H, Zeh, H, Izbicki, J, He, J, Laukkarinen, J, Dejong, C, Lillemoe, K, Conlon, K, Takaori, K, Gianotti, L, Besselink, M, Del Chiaro, M, Montorsi, M, Tanaka, M, Bockhorn, M, Adham, M, Olah, A, Salvia, R, Shrikhande, S, Hackert, T, Shimosegawa, T, Zureikat, A, Ceyhan, G, Peng, Y, Wang, G, Huang, X, Dervenis, C, Bassi, C, Neoptolemos, J, Buchler, M, Miao Y., Lu Z., Yeo C. J., Vollmer C. M., Fernandez-del Castillo C., Ghaneh P., Halloran C. M., Kleeff J., de Rooij T., Werner J., Falconi M., Friess H., Zeh H. J., Izbicki J. R., He J., Laukkarinen J., Dejong C. H., Lillemoe K. D., Conlon K., Takaori K., Gianotti L., Besselink M. G., Del Chiaro M., Montorsi M., Tanaka M., Bockhorn M., Adham M., Olah A., Salvia R., Shrikhande S. V., Hackert T., Shimosegawa T., Zureikat A. H., Ceyhan G. O., Peng Y., Wang G., Huang X., Dervenis C., Bassi C., Neoptolemos J. P., Buchler M. W., Miao, Y, Lu, Z, Yeo, C, Vollmer, C, Fernandez-del Castillo, C, Ghaneh, P, Halloran, C, Kleeff, J, de Rooij, T, Werner, J, Falconi, M, Friess, H, Zeh, H, Izbicki, J, He, J, Laukkarinen, J, Dejong, C, Lillemoe, K, Conlon, K, Takaori, K, Gianotti, L, Besselink, M, Del Chiaro, M, Montorsi, M, Tanaka, M, Bockhorn, M, Adham, M, Olah, A, Salvia, R, Shrikhande, S, Hackert, T, Shimosegawa, T, Zureikat, A, Ceyhan, G, Peng, Y, Wang, G, Huang, X, Dervenis, C, Bassi, C, Neoptolemos, J, Buchler, M, Miao Y., Lu Z., Yeo C. J., Vollmer C. M., Fernandez-del Castillo C., Ghaneh P., Halloran C. M., Kleeff J., de Rooij T., Werner J., Falconi M., Friess H., Zeh H. J., Izbicki J. R., He J., Laukkarinen J., Dejong C. H., Lillemoe K. D., Conlon K., Takaori K., Gianotti L., Besselink M. G., Del Chiaro M., Montorsi M., Tanaka M., Bockhorn M., Adham M., Olah A., Salvia R., Shrikhande S. V., Hackert T., Shimosegawa T., Zureikat A. H., Ceyhan G. O., Peng Y., Wang G., Huang X., Dervenis C., Bassi C., Neoptolemos J. P., and Buchler M. W.

Abstract

Background: The aim was to evaluate the various operative techniques and outcomes used to manage the pancreatic transection plane (or stump) during a left (distal) pancreatectomy and to develop expert consensus guidelines. Methods: Evidence-based, clinically relevant questions were discussed and then were circulated among members of the International Study Group of Pancreatic Surgery. After agreement on the questions and statements, voting in a 9-point Likert scale was used to gauge the level of objective support for each. Results: Studies using the International Study Group of Pancreatic Surgery definition of postoperative pancreatic fistula including 16 randomized trials were reviewed to generate a series of statements set into 14 domains. There was strong consensus in the following statements: there was no difference in the postoperative pancreatic fistula rate after left pancreatectomy between the handsewn and stapler techniques; a stapling technique could not be used in all cases of left pancreatectomy; the use of an energy-based tissue sealant or a chemical sealant device or combinations of these did not impact the postoperative pancreatic fistula rate; there was no difference in the postoperative pancreatic fistula rate between the open, laparoscopic, or robotic approaches; and there are 1 or more clinically important, patient-related risk factors associated with the postoperative pancreatic fistula rate. There was weak or conditional agreement on the use of prophylactic somatostatin analogs, stents, stump closure, stump anastomosis, and the role of abdominal drains. Conclusion: Areas of strong consensus suggests a change in clinical practice and priority setting. Eight domains with lower agreement will require novel approaches and large multicenter studies to determine future key areas of practice.

Published
2020

14. Education Scholarship in Higher Education in South Africa, 1995-2006

Author

Deacon, R., Osman, R., and Buchler, M.

Abstract

This article reports on findings pertaining to education scholarship in higher education drawn from a wider study on all education research in South Africa from 1995 to 2006. After briefly outlining pertinent aspects of the wider study, it offers a preliminary and descriptive account of what were found to be primary research themes in higher education studies, including the socio-political implications of higher education transformation, the debate over the "Africanisation" of higher education, the promotion of indigenous knowledges, equity and excellence in higher education policy, increasing participation and access though academic development and the recognition of prior learning, the acquisition of academic literacy, assessment, and accountability and autonomy. (Contains 5 notes.)

Published
2009

17. Diagnostic strategy and timing of intervention in infected necrotizing pancreatitis: an international expert survey and case vignette study

Author

van Grinsven, Janneke, van Brunschot, Sandra, Bakker, Olaf J., Bollen, Thomas L., Boermeester, Marja A., Bruno, Marco J., Dejong, Cornelis H., Dijkgraaf, Marcel G., van Eijck, Casper H., Fockens, Paul, van Goor, Harry, Gooszen, Hein G., Horvath, Karen D., van Lienden, Krijn P., van Santvoort, Hjalmar C., Besselink, Marc G., Abdelhafez, M, Andersson, R, Andren-Sandberg, A, Ashley, S, van Baal, M, Baron, T, Bassi, C, Bradley, E, Buchler, M, Cappendijk, V, Carter, R, Charnley, R, Coelho, D, Connor, S, Dellinger, P, Dervenis, C, Deviere, J, Doctor, N, Dudeja, V, En-qiang, M, Escourrou, J, Fagenholz, P, Farkas, G, Forsmark, C, Freeman, M, Freeny, P, French, J, Friess, H, Gardner, T, Goetzinger, P, Haveman, J, Hofker, S, Imrie, C, Isaji, S, Isenmann, R, Klar, E, Laméris, J, Lerch, M, Lévy, P, Lillemoe, K, Löhr, M, Mayerle, J, Mayumi, T, Mittal, A, Moessner, J, Morgan, D, Mortele, K, Nealon, W, Neoptolemos, J, Nieuwenhuijs, V, Nordback, I, Olah, A, Oppong, K, Padbury, R, Papachristou, G, Parks, R, Poley, J, Radenkovic, D, Raraty, M, Rau, B, Rebours, V, Rische, S, Runzi, M, Sainani, N, Sarr, M, Schaapherder, S, Seewald, S, Seifert, H, Shimosegawa, T, Silverman, S, Singh, V, Siriwardena, A, Steinberg, W, Sutton, R, Takeda, K, Timmer, R, Vege, S, Voermans, R, de Waele, J, Wang, Ch, Warshaw, A, Werner, J, Weusten, B, Whitcomb, D, Wig, J, Windsor, J, and Zyromski, N

Published
2015
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28. Diagnosis and treatment of pancreatic duct disruption or disconnection: an international expert survey and case vignette study

Author

Boxhoorn, Lotte, primary, Timmerhuis, Hester C., additional, Verdonk, Robert C., additional, Besselink, Marc G., additional, Bollen, Thomas L., additional, Bruno, Marco J., additional, Elmunzer, B. Joseph, additional, Fockens, Paul, additional, Horvath, Karen D., additional, van Santvoort, Hjalmar C., additional, Voermans, Rogier P., additional, Albert, J., additional, Arvanitakis, M., additional, Badaoui, A., additional, Barthet, M., additional, van Biervliet, G., additional, Bradley, E., additional, Boermeester, M., additional, Buchler, M., additional, Cappendijk, V., additional, Charnley, R., additional, Connor, S., additional, Dejong, C., additional, Dellinger, P., additional, Dervenis, C., additional, Deviere, J., additional, Dumonceau, J., additional, van Eijck, C., additional, Fagenholz, P., additional, Castillo, C.Fernandez-del, additional, Forsmark, C., additional, Freeman, M., additional, French, J., additional, van Goor, H., additional, Haveman, J.W., additional, van Hooft, J., additional, Hucl, T., additional, Isaji, S., additional, Jagielski, M., additional, Karjula, H., additional, Lerch, M., additional, Lévy, P., additional, Lillemoe, K., additional, Löhr, M., additional, Mayerle, J., additional, Mittal, A., additional, Morgan, D., additional, Moon, S., additional, Nieuwenhuijs, V., additional, Sarr, M., additional, Seewald, S., additional, Sherman, S., additional, Singh, V., additional, Siriwardena, A., additional, Stommel, M., additional, Tann, M., additional, Téllez-Avina, F., additional, Timmer, R., additional, Traverso, W., additional, Radenkovic, D., additional, Rana, S., additional, Rebours, V., additional, Pelaez-Luna, M., additional, Poley, J.W., additional, Windsor, J., additional, Zaheer, A., additional, and Zyromski, N., additional

Published
2021
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29. Benchmarking plant diversity of Palaearctic grasslands and other open habitats

Author

Biurrun, I. (Idoia), Pielech, R. (Remigiusz), Dembicz, I. (Iwona), Gillet, F. (Francois), Kozub, L. (Lukasz), Marceno, C. (Corrado), Reitalu, T. (Triin), Van Meerbeek, K. (Koenraad), Guarino, R. (Riccardo), Chytry, M. (Milan), Pakeman, R. J. (Robin J.), Preislerova, Z. (Zdenka), Axmanova, I. (Irena), Burrascano, S. (Sabina), Bartha, S. (Sandor), Boch, S. (Steffen), Bruun, H. H. (Hans Henrik), Conradi, T. (Timo), De Frenne, P. (Pieter), Essl, F. (Franz), Filibeck, G. (Goffredo), Hajek, M. (Michal), Jimenez-Alfaro, B. (Borja), Kuzemko, A. (Anna), Molnar, Z. (Zsolt), Partel, M. (Meelis), Patsch, R. (Ricarda), Prentice, H. C. (Honor C.), Rolecek, J. (Jan), Sutcliffe, L. M. (Laura M. E.), Terzi, M. (Massimo), Winkler, M. (Manuela), Wu, J. (Jianshuang), Acic, S. (Svetlana), Acosta, A. T. (Alicia T. R.), Afif, E. (Elias), Akasaka, M. (Munemitsu), Alatalo, J. M. (Juha M.), Aleffi, M. (Michele), Aleksanyan, A. (Alla), Ali, A. (Arshad), Apostolova, I. (Iva), Ashouri, P. (Parvaneh), Batori, Z. (Zoltan), Baumann, E. (Esther), Becker, T. (Thomas), Belonovskaya, E. (Elena), Benito Alonso, J. L. (Jose Luis), Berastegi, A. (Asun), Bergamini, A. (Ariel), Bhatta, K. P. (Kuber Prasad), Bonini, I. (Ilaria), Buchler, M.-O. (Marc-Olivier), Budzhak, V. (Vasyl), Bueno, A. (Alvaro), Buldrini, F. (Fabrizio), Campos, J. A. (Juan Antonio), Cancellieri, L. (Laura), Carboni, M. (Marta), Ceulemans, T. (Tobias), Chiarucci, A. (Alessandro), Chocarro, C. (Cristina), Conti, L. (Luisa), Csergo, A. M. (Anna Maria), Cykowska-Marzencka, B. (Beata), Czarniecka-Wiera, M. (Marta), Czarnocka-Cieciura, M. (Marta), Czortek, P. (Patryk), Danihelka, J. (Jiri), Bello, F. (Francesco), Deak, B. (Balazs), Demeter, L. (Laszlo), Deng, L. (Lei), Diekmann, M. (Martin), Dolezal, J. (Jiri), Dolnik, C. (Christian), Drevojan, P. (Pavel), Dupre, C. (Cecilia), Ecker, K. (Klaus), Ejtehadi, H. (Hamid), Erschbamer, B. (Brigitta), Etayo, J. (Javier), Etzold, J. (Jonathan), Farkas, T. (Tunde), Farzam, M. (Mohammad), Fayvush, G. (George), Fernandez Calzado, M. R. (Maria Rosa), Finckh, M. (Manfred), Fjellstad, W. (Wendy), Fotiadis, G. (Georgios), Garcia-Magro, D. (Daniel), Garcia-Mijangos, I. (Itziar), Gavilan, R. G. (Rosario G.), Germany, M. (Markus), Ghafari, S. (Sahar), del Galdo, G. P. (Gian Pietro Giusso), Grytnes, J.-A. (John-Arvid), Guler, B. (Behlul), Gutierrez-Giron, A. (Alba), Helm, A. (Aveliina), Herrera, M. (Mercedes), Hullbusch, E. M. (Elisabeth M.), Ingerpuu, N. (Nele), Jaegerbrand, A. K. (Annika K.), Jandt, U. (Ute), Janisova, M. (Monika), Jeanneret, P. (Philippe), Jeltsch, F. (Florian), Jensen, K. (Kai), Jentsch, A. (Anke), Kacki, Z. (Zygmunt), Kakinuma, K. (Kaoru), Kapfer, J. (Jutta), Kargar, M. (Mansoureh), Kelemen, A. (Andras), Kiehl, K. (Kathrin), Kirschner, P. (Philipp), Koyama, A. (Asuka), Langer, N. (Nancy), Lazzaro, L. (Lorenzo), Leps, J. (Jan), Li, C.-F. (Ching-Feng), Li, F. Y. (Frank Yonghong), Liendo, D. (Diego), Lindborg, R. (Regina), Loebel, S. (Swantje), Lomba, A. (Angela), Lososova, Z. (Zdenka), Lustyk, P. (Pavel), Luzuriaga, A. L. (Arantzazu L.), Ma, W. (Wenhong), Maccherini, S. (Simona), Magnes, M. (Martin), Malicki, M. (Marek), Manthey, M. (Michael), Mardari, C. (Constantin), May, F. (Felix), Mayrhofer, H. (Helmut), Meier, E. S. (Eliane Seraina), Memariani, F. (Farshid), Merunkova, K. (Kristina), Michelsen, O. (Ottar), Molero Mesa, J. (Joaquin), Moradi, H. (Halime), Moysiyenko, I. (Ivan), Mugnai, M. (Michele), Naqinezhad, A. (Alireza), Natcheva, R. (Rayna), Ninot, J. M. (Josep M.), Nobis, M. (Marcin), Noroozi, J. (Jalil), Nowak, A. (Arkadiusz), Onipchenko, V. (Vladimir), Palpurina, S. (Salza), Pauli, H. (Harald), Pedashenko, H. (Hristo), Pedersen, C. (Christian), Peet, R. K. (Robert K.), Perez-Haase, A. (Aaron), Peters, J. (Jan), Pipenbaher, N. (Natasa), Pirini, C. (Chrisoula), Pladevall-Izard, E. (Eulalia), Pleskova, Z. (Zuzana), Potenza, G. (Giovanna), Rahmanian, S. (Soroor), Rodriguez-Rojo, M. P. (Maria Pilar), Ronkin, V. (Vladimir), Rosati, L. (Leonardo), Ruprecht, E. (Eszter), Rusina, S. (Solvita), Sabovljevic, M. (Marko), Sanaei, A. (Anvar), Sanchez, A. M. (Ana M.), Santi, F. (Francesco), Savchenko, G. (Galina), Teresa Sebastia, M. (Maria), Shyriaieva, D. (Dariia), Silva, V. (Vasco), Skornik, S. (Sonja), Smerdova, E. (Eva), Sonkoly, J. (Judit), Sperandii, M. G. (Marta Gaia), Staniaszek-Kik, M. (Monika), Stevens, C. (Carly), Stifter, S. (Simon), Suchrow, S. (Sigrid), Swacha, G. (Grzegorz), Swierszcz, S. (Sebastian), Talebi, A. (Amir), Teleki, B. (Balazs), Tichy, L. (Lubomir), Tolgyesi, C. (Csaba), Torca, M. (Marta), Torok, P. (Peter), Tsarevskaya, N. (Nadezda), Tsiripidis, I. (Ioannis), Turisova, I. (Ingrid), Ushimaru, A. (Atushi), Valko, O. (Orsolya), Van Mechelen, C. (Carmen), Vanneste, T. (Thomas), Vasheniak, I. (Iuliia), Vassilev, K. (Kiril), Viciani, D. (Daniele), Villar, L. (Luis), Virtanen, R. (Risto), Vitasovic-Kosic, I. (Ivana), Vojtko, A. (Andras), Vynokurov, D. (Denys), Walden, E. (Emelie), Wang, Y. (Yun), Weiser, F. (Frank), Wen, L. (Lu), Wesche, K. (Karsten), White, H. (Hannah), Widmer, S. (Stefan), Wolfrum, S. (Sebastian), Wrobel, A. (Anna), Yuan, Z. (Zuoqiang), Zeleny, D. (David), Zhao, L. (Liqing), Dengler, J. (Jurgen), Biurrun, I. (Idoia), Pielech, R. (Remigiusz), Dembicz, I. (Iwona), Gillet, F. (Francois), Kozub, L. (Lukasz), Marceno, C. (Corrado), Reitalu, T. (Triin), Van Meerbeek, K. (Koenraad), Guarino, R. (Riccardo), Chytry, M. (Milan), Pakeman, R. J. (Robin J.), Preislerova, Z. (Zdenka), Axmanova, I. (Irena), Burrascano, S. (Sabina), Bartha, S. (Sandor), Boch, S. (Steffen), Bruun, H. H. (Hans Henrik), Conradi, T. (Timo), De Frenne, P. (Pieter), Essl, F. (Franz), Filibeck, G. (Goffredo), Hajek, M. (Michal), Jimenez-Alfaro, B. (Borja), Kuzemko, A. (Anna), Molnar, Z. (Zsolt), Partel, M. (Meelis), Patsch, R. (Ricarda), Prentice, H. C. (Honor C.), Rolecek, J. (Jan), Sutcliffe, L. M. (Laura M. E.), Terzi, M. (Massimo), Winkler, M. (Manuela), Wu, J. (Jianshuang), Acic, S. (Svetlana), Acosta, A. T. (Alicia T. R.), Afif, E. (Elias), Akasaka, M. (Munemitsu), Alatalo, J. M. (Juha M.), Aleffi, M. (Michele), Aleksanyan, A. (Alla), Ali, A. (Arshad), Apostolova, I. (Iva), Ashouri, P. (Parvaneh), Batori, Z. (Zoltan), Baumann, E. (Esther), Becker, T. (Thomas), Belonovskaya, E. (Elena), Benito Alonso, J. L. (Jose Luis), Berastegi, A. (Asun), Bergamini, A. (Ariel), Bhatta, K. P. (Kuber Prasad), Bonini, I. (Ilaria), Buchler, M.-O. (Marc-Olivier), Budzhak, V. (Vasyl), Bueno, A. (Alvaro), Buldrini, F. (Fabrizio), Campos, J. A. (Juan Antonio), Cancellieri, L. (Laura), Carboni, M. (Marta), Ceulemans, T. (Tobias), Chiarucci, A. (Alessandro), Chocarro, C. (Cristina), Conti, L. (Luisa), Csergo, A. M. (Anna Maria), Cykowska-Marzencka, B. (Beata), Czarniecka-Wiera, M. (Marta), Czarnocka-Cieciura, M. (Marta), Czortek, P. (Patryk), Danihelka, J. (Jiri), Bello, F. (Francesco), Deak, B. (Balazs), Demeter, L. (Laszlo), Deng, L. (Lei), Diekmann, M. (Martin), Dolezal, J. (Jiri), Dolnik, C. (Christian), Drevojan, P. (Pavel), Dupre, C. (Cecilia), Ecker, K. (Klaus), Ejtehadi, H. (Hamid), Erschbamer, B. (Brigitta), Etayo, J. (Javier), Etzold, J. (Jonathan), Farkas, T. (Tunde), Farzam, M. (Mohammad), Fayvush, G. (George), Fernandez Calzado, M. R. (Maria Rosa), Finckh, M. (Manfred), Fjellstad, W. (Wendy), Fotiadis, G. (Georgios), Garcia-Magro, D. (Daniel), Garcia-Mijangos, I. (Itziar), Gavilan, R. G. (Rosario G.), Germany, M. (Markus), Ghafari, S. (Sahar), del Galdo, G. P. (Gian Pietro Giusso), Grytnes, J.-A. (John-Arvid), Guler, B. (Behlul), Gutierrez-Giron, A. (Alba), Helm, A. (Aveliina), Herrera, M. (Mercedes), Hullbusch, E. M. (Elisabeth M.), Ingerpuu, N. (Nele), Jaegerbrand, A. K. (Annika K.), Jandt, U. (Ute), Janisova, M. (Monika), Jeanneret, P. (Philippe), Jeltsch, F. (Florian), Jensen, K. (Kai), Jentsch, A. (Anke), Kacki, Z. (Zygmunt), Kakinuma, K. (Kaoru), Kapfer, J. (Jutta), Kargar, M. (Mansoureh), Kelemen, A. (Andras), Kiehl, K. (Kathrin), Kirschner, P. (Philipp), Koyama, A. (Asuka), Langer, N. (Nancy), Lazzaro, L. (Lorenzo), Leps, J. (Jan), Li, C.-F. (Ching-Feng), Li, F. Y. (Frank Yonghong), Liendo, D. (Diego), Lindborg, R. (Regina), Loebel, S. (Swantje), Lomba, A. (Angela), Lososova, Z. (Zdenka), Lustyk, P. (Pavel), Luzuriaga, A. L. (Arantzazu L.), Ma, W. (Wenhong), Maccherini, S. (Simona), Magnes, M. (Martin), Malicki, M. (Marek), Manthey, M. (Michael), Mardari, C. (Constantin), May, F. (Felix), Mayrhofer, H. (Helmut), Meier, E. S. (Eliane Seraina), Memariani, F. (Farshid), Merunkova, K. (Kristina), Michelsen, O. (Ottar), Molero Mesa, J. (Joaquin), Moradi, H. (Halime), Moysiyenko, I. (Ivan), Mugnai, M. (Michele), Naqinezhad, A. (Alireza), Natcheva, R. (Rayna), Ninot, J. M. (Josep M.), Nobis, M. (Marcin), Noroozi, J. (Jalil), Nowak, A. (Arkadiusz), Onipchenko, V. (Vladimir), Palpurina, S. (Salza), Pauli, H. (Harald), Pedashenko, H. (Hristo), Pedersen, C. (Christian), Peet, R. K. (Robert K.), Perez-Haase, A. (Aaron), Peters, J. (Jan), Pipenbaher, N. (Natasa), Pirini, C. (Chrisoula), Pladevall-Izard, E. (Eulalia), Pleskova, Z. (Zuzana), Potenza, G. (Giovanna), Rahmanian, S. (Soroor), Rodriguez-Rojo, M. P. (Maria Pilar), Ronkin, V. (Vladimir), Rosati, L. (Leonardo), Ruprecht, E. (Eszter), Rusina, S. (Solvita), Sabovljevic, M. (Marko), Sanaei, A. (Anvar), Sanchez, A. M. (Ana M.), Santi, F. (Francesco), Savchenko, G. (Galina), Teresa Sebastia, M. (Maria), Shyriaieva, D. (Dariia), Silva, V. (Vasco), Skornik, S. (Sonja), Smerdova, E. (Eva), Sonkoly, J. (Judit), Sperandii, M. G. (Marta Gaia), Staniaszek-Kik, M. (Monika), Stevens, C. (Carly), Stifter, S. (Simon), Suchrow, S. (Sigrid), Swacha, G. (Grzegorz), Swierszcz, S. (Sebastian), Talebi, A. (Amir), Teleki, B. (Balazs), Tichy, L. (Lubomir), Tolgyesi, C. (Csaba), Torca, M. (Marta), Torok, P. (Peter), Tsarevskaya, N. (Nadezda), Tsiripidis, I. (Ioannis), Turisova, I. (Ingrid), Ushimaru, A. (Atushi), Valko, O. (Orsolya), Van Mechelen, C. (Carmen), Vanneste, T. (Thomas), Vasheniak, I. (Iuliia), Vassilev, K. (Kiril), Viciani, D. (Daniele), Villar, L. (Luis), Virtanen, R. (Risto), Vitasovic-Kosic, I. (Ivana), Vojtko, A. (Andras), Vynokurov, D. (Denys), Walden, E. (Emelie), Wang, Y. (Yun), Weiser, F. (Frank), Wen, L. (Lu), Wesche, K. (Karsten), White, H. (Hannah), Widmer, S. (Stefan), Wolfrum, S. (Sebastian), Wrobel, A. (Anna), Yuan, Z. (Zuoqiang), Zeleny, D. (David), Zhao, L. (Liqing), and Dengler, J. (Jurgen)

Abstract

Aims: Understanding fine-grain diversity patterns across large spatial extents is fundamental for macroecological research and biodiversity conservation. Using the GrassPlot database, we provide benchmarks of fine-grain richness values of Palaearctic open habitats for vascular plants, bryophytes, lichens and complete vegetation (i.e., the sum of the former three groups). Location: Palaearctic biogeographic realm. Methods: We used 126,524 plots of eight standard grain sizes from the GrassPlot database: 0.0001, 0.001, 0.01, 0.1, 1, 10, 100 and 1,000 m² and calculated the mean richness and standard deviations, as well as maximum, minimum, median, and first and third quartiles for each combination of grain size, taxonomic group, biome, region, vegetation type and phytosociological class. Results: Patterns of plant diversity in vegetation types and biomes differ across grain sizes and taxonomic groups. Overall, secondary (mostly semi-natural) grasslands and natural grasslands are the richest vegetation type. The open-access file ”GrassPlot Diversity Benchmarks” and the web tool “GrassPlot Diversity Explorer” are now available online (https://edgg.org/databases/GrasslandDiversityExplorer) and provide more insights into species richness patterns in the Palaearctic open habitats. Conclusions: The GrassPlot Diversity Benchmarks provide high-quality data on species richness in open habitat types across the Palaearctic. These benchmark data can be used in vegetation ecology, macroecology, biodiversity conservation and data quality checking. While the amount of data in the underlying GrassPlot database and their spatial coverage are smaller than in other extensive vegetation-plot databases, species recordings in GrassPlot are on average more complete, making it a valuable complementary data source in macroecology.

Published
2021

35. The Spiesser Study: Results at 8 Years.: Abstract# B983

Author

Gatault, P., Snanoudj, R., Toupance, O., Weestel, F., de Ligny, Hurault B., Buchler, M., Rerolle, J., Thierry, A., Moulin, B., Subra, J., Heng, A., Etienne, I., LePogamp, P., Sautenet, B., and Lebranchu, Y.

Published
2014

37. Duodenum erhaltende Pankreaskopfresektion versus Pankreatikoduodenektomie bei der Behandlung der chronischen Pankreatitis — eine systematische Übersichtsarbeit mit Meta-Analyse

Author

Diener, Markus K., Rahbari, N. N., Fischer, L., Antes, G., Buchler, M. W., Seiler, C. M., Bruch, H. P., editor, Büchler, M. W., editor, Buhr, H. J., editor, Hohenberger, W., editor, Klar, E., editor, Post, S., editor, Schilling, M., editor, Schumpelick, V., editor, Siewert, J. R., editor, Thiede, A., editor, Becker, H., editor, Bittner, R., editor, Függer, R., editor, Köckerling, F., editor, Saeger, H. D., editor, Zornig, C., editor, Hölscher, A., editor, Izbicki, J. R., editor, Jauch, K. W., editor, Senninger, N., editor, Allgayer, H., editor, Bruns, C. J., editor, Celik, I., editor, Fries, H., editor, Kalthoff, H., editor, Schackert, H. K., editor, Brückner, U. B., editor, Ertel, W., editor, Faist, E., editor, Holzheimer, R. G., editor, Holzmann, B., editor, Schade, U. F., editor, Vollmar, B., editor, Heidecke, C. D., editor, Menger, M. D., editor, Neugebauer, E., editor, Spiegel, H. U., editor, Germann, G., editor, Haas, N., editor, Langer, S., editor, Machens, H. G., editor, Stark, G. B., editor, Steinau, H. U., editor, Haverich, A., editor, Heberer, M., editor, Fitze, G., editor, Roth, H., editor, von Schweinitz, D., editor, Waag, K. L., editor, Altendorf-Hofmann, A., editor, Lehnert, T., editor, Lorenz, W., editor, Ohmann, C., editor, Bechstein, W. O., editor, Broelsch, C., editor, Hopt, U., editor, Klempnauer, J., editor, Fändrich, F., editor, Markus, B., editor, Minor, T., editor, Neuhaus, P., editor, Wonigeit, K., editor, Dralle, H., editor, Goretzki, P. E., editor, Rothmund, M., editor, Bühren, V., editor, Josten, C., editor, Muhr, G., editor, Nast-Kolb, D., editor, Stürmer, K. M., editor, Trentz, O., editor, Brunkwall, J., editor, Sandmann, W., editor, Schmitz-Rixen, T., editor, Storck, M., editor, Branscheid, D., editor, Dienemann, H., editor, Hirner, A., editor, Passlick, B., editor, Toomes, H., editor, Beyersdorf, F., editor, Hetzer, R., editor, Schäfers, H. J., editor, Steinsträßer, L., editor, Vogt, P., editor, Arbogast, R., editor, and Bauer, H., editor

Published
2008
Full Text
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38. Nutritional support and therapy in pancreatic surgery: A position paper of the International Study Group on Pancreatic Surgery (ISGPS)

Author

Gianotti, L, Besselink, M, Sandini, M, Hackert, T, Conlon, K, Gerritsen, A, Griffin, O, Fingerhut, A, Probst, P, Hilal, M, Marchegiani, G, Nappo, G, Zerbi, A, Amodio, A, Perinel, J, Adham, M, Raimondo, M, Asbun, H, Sato, A, Takaori, K, Shrikhande, S, Del Chiaro, M, Bockhorn, M, Izbicki, J, Dervenis, C, Charnley, R, Martignoni, M, Friess, H, de Pretis, N, Radenkovic, D, Montorsi, M, Sarr, M, Vollmer, C, Frulloni, L, Buchler, M, Bassi, C, Gianotti L., Besselink M. G., Sandini M., Hackert T., Conlon K., Gerritsen A., Griffin O., Fingerhut A., Probst P., Hilal M. A., Marchegiani G., Nappo G., Zerbi A., Amodio A., Perinel J., Adham M., Raimondo M., Asbun H. J., Sato A., Takaori K., Shrikhande S. V., Del Chiaro M., Bockhorn M., Izbicki J. R., Dervenis C., Charnley R. M., Martignoni M. E., Friess H., de Pretis N., Radenkovic D., Montorsi M., Sarr M. G., Vollmer C. M., Frulloni L., Buchler M. W., Bassi C., Gianotti, L, Besselink, M, Sandini, M, Hackert, T, Conlon, K, Gerritsen, A, Griffin, O, Fingerhut, A, Probst, P, Hilal, M, Marchegiani, G, Nappo, G, Zerbi, A, Amodio, A, Perinel, J, Adham, M, Raimondo, M, Asbun, H, Sato, A, Takaori, K, Shrikhande, S, Del Chiaro, M, Bockhorn, M, Izbicki, J, Dervenis, C, Charnley, R, Martignoni, M, Friess, H, de Pretis, N, Radenkovic, D, Montorsi, M, Sarr, M, Vollmer, C, Frulloni, L, Buchler, M, Bassi, C, Gianotti L., Besselink M. G., Sandini M., Hackert T., Conlon K., Gerritsen A., Griffin O., Fingerhut A., Probst P., Hilal M. A., Marchegiani G., Nappo G., Zerbi A., Amodio A., Perinel J., Adham M., Raimondo M., Asbun H. J., Sato A., Takaori K., Shrikhande S. V., Del Chiaro M., Bockhorn M., Izbicki J. R., Dervenis C., Charnley R. M., Martignoni M. E., Friess H., de Pretis N., Radenkovic D., Montorsi M., Sarr M. G., Vollmer C. M., Frulloni L., Buchler M. W., and Bassi C.

Abstract

Background: The optimal nutritional therapy in the field of pancreatic surgery is still debated. Methods: An international panel of recognized pancreatic surgeons and pancreatologists decided that the topic of nutritional support was of importance in pancreatic surgery. Thus, they reviewed the best contemporary literature and worked to develop a position paper to provide evidence supporting the integration of appropriate nutritional support into the overall management of patients undergoing pancreatic resection. Strength of recommendation and quality of evidence were based on the approach of the grading of recommendations assessment, development and evaluation Working Group. Results: The measurement of nutritional status should be part of routine preoperative assessment because malnutrition is a recognized risk factor for surgery-related complications. In addition to patient's weight loss and body mass index, measurement of sarcopenia and sarcopenic obesity should be considered in the preoperative evaluation because they are strong predictors of poor short-term and long-term outcomes. The available data do not show any definitive nutritional advantages for one specific type of gastrointestinal reconstruction technique after pancreatoduodenectomy over the others. Postoperative early resumption of oral intake is safe and should be encouraged within enhanced recovery protocols, but in the case of severe postoperative complications or poor tolerance of oral food after the operation, supplementary artificial nutrition should be started at once. At present, there is not enough evidence to show the benefit of avoiding oral intake in clinically stable patients who are complicated by a clinically irrelevant postoperative pancreatic fistula (a so-called biochemical leak), while special caution should be given to feeding patients with clinically relevant postoperative pancreatic fistula orally. When an artificial nutritional support is needed, enteral nutrition is preferred wh

Published
2018

39. Ribavirin for Hepatitis E Virus Infection After Organ Transplantation

Author

Kamar, Nassim, Legrand-Abravanel, Florence, Behrendt, Patrick, Hofmann, Jörg, Pageaux, Georges Phillippe, Barbet, Christelle, Moal, Valerie, Couzi, Lionel, Horvatits, Thomas, de Man, Robert, Cassuto, Elisabeth, Elsharkawy, Ahmed, Riezebos-Brilman, Annelies, Scemla, Anne, Hillaire, Sophie, Donnelly, Mhairi, Radenne, Sylvie, Sayegh, Johnny, Garrouste, Cyril, Dumortier, Jérôme, Glowaki, François, Matignon, Marie, Coilly, Audrey, Figueres, Lucile, Mousson, Christiane, Minello, Anne, Dharancy, Sébastien, Rerolle, Jean Philippe, Lebray, Pascal, Etienne, Isabelle, Perrin, Peggy, Choi, Mira, Olivier, Marion, Izopet, Jacques, Bellière, J, Cointault, O., del Bello, Arnaud, Espostio, L, Hebral, A, Lavayssière, L, Lhomme, S, Mansuy, J, Wedemeyer, H, Nickel, P, Bismuth, M., Stefic, K, Buchler, M., D’alteroche, L, Colson, P., Bufton, S, Ramière, C, Trimoulet, P., Pischke, S, Todesco, E, Sberro Soussan, R, Legendre, C, Mallet, V., Johannessen, I, Simpson, K, Service de Néphrologie - Hypertension Artérielle Dialyse - Transplantation, Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Toulouse [Toulouse], Université Fédérale Toulouse Midi-Pyrénées, Hannover Medical School [Hannover] (MHH), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Département d'Hépato-Gastroentérologie et de Transplantation Hépatique [CHU Saint-Eloi], Hôpital Saint Eloi (CHRU Montpellier), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université de Montpellier (UM), Service de néphrologie et immunologie clinique [CHRU Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau-Université de Tours (UT), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Assistance Publique - Hôpitaux de Marseille (APHM), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), CHU Bordeaux [Bordeaux], Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), Erasmus University Medical Center [Rotterdam] (Erasmus MC), Centre Hospitalier Universitaire de Nice (CHU Nice), University Hospitals Birmingham [Birmingham, Royaume-Uni], University Medical Center Groningen [Groningen] (UMCG), Réseau CENTAURE, Hôpital Foch [Suresnes], Royal Infirmary of Edinburgh, Service d'Hépatologie [Hôpital de la Croix-Rousse - HCL], Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), CHU Clermont-Ferrand, Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Hôpital Paul Brousse, Centre hospitalier universitaire de Nantes (CHU Nantes), Service de néphrologie (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Service d'Hépato-Gastro-Entérologie (CHU de Dijon), Hôpital Claude Huriez [Lille], CHU Lille, Service de Néphrologie, Dialyse, Transplantations [CHU Limoges], CHU Limoges, Service d'Hépato-Gastro-Entérologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Rouen, Normandie Université (NU), CHU Strasbourg, Département de Néphrologie et Transplantation d'organes [Toulouse], Service de virologie et d'immunologie biologique, CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Gastroenterology & Hepatology, CHU Toulouse [Toulouse]-Hôpital de Rangueil, Université de Montpellier (UM)-CHU Saint-Eloi, Service de néphrologie et immunologie clinique [CHRU Tours] (EA4245 UT), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau-Université de Tours, Département de Néphrologie et Transplantation d'organes, Hôpital de Rangueil, CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Service de néphrologie et immunologie clinique, Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université de Toulouse (UT), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Département de Néphrologie et Transplantation d'organes [CHU Toulouse], Pôle Urologie - Néphrologie - Dialyse - Transplantations - Brûlés - Chirurgie plastique - Explorations fonctionnelles et physiologiques [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-IFR10

Subjects
0301 basic medicine, MESH: Antiviral Agents / therapeutic use, Sofosbuvir, viruses, medicine.disease_cause, Gastroenterology, THERAPY, Organ transplantation, Hepatitis E virus / genetics, Hepatitis E / drug therapy, Humans, chemistry.chemical_compound, 0302 clinical medicine, Hepatitis E virus, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Medicine, MUTATION, MESH: Hepatitis E* / drug therapy, POLYMERASE, organ transplantation, virus diseases, MESH: Ribavirin / therapeutic use, Anemia, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, Hepatitis E, anemia, 3. Good health, PREDICTS, Sustained virological response, Infectious Diseases, MESH: RNA, Viral, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, RNA, Viral, 030211 gastroenterology & hepatology, sustained virological response, medicine.drug, Microbiology (medical), medicine.medical_specialty, ribavirin, MESH: Organ Transplantation / adverse effects, RNA, Viral Retrospective Studies, Ribavirin / therapeutic use, Alpha interferon, MESH: Organ Transplantation* / adverse effects, hepatitis E virus, Antiviral Agents, Virus, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Internal medicine, Ribavirin, Retrospective Studies, MESH: Hepatitis E virus* / genetics, MESH: Humans, business.industry, Retrospective cohort study, MESH: Retrospective Studies, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, IN-VITRO, medicine.disease, digestive system diseases, 030104 developmental biology, chemistry, SOFOSBUVIR, HEV, REPLICATION, INTERFERON-ALPHA, business
Abstract

Background Ribavirin is currently recommended for treating chronic hepatitis E virus (HEV) infection. This retrospective European multicenter study aimed to assess the sustained virological response (SVR) in a large cohort of solid organ transplant (SOT) recipients with chronic HEV infection treated with ribavirin monotherapy (N = 255), to identify the predictive factors for SVR, and to evaluate the impact of HEV RNA mutations on virological response. Methods Data from 255 SOT recipients with chronic HEV infection from 30 European centers were analyzed. Ribavirin was given at the median dose of 600 (range, 29–1200) mg/day (mean, 8.6 ± 3.6 mg/kg/day) for a median duration of 3 (range, 0.25–18) months. Results After a first course of ribavirin, the SVR rate was 81.2%. It increased to 89.8% when some patients were offered a second course of ribavirin. An increased lymphocyte count at the initiation of therapy was a predictive factor for SVR, while poor hematological tolerance of ribavirin requiring its dose reduction (28%) and blood transfusion (15.7%) were associated with more relapse after ribavirin cessation. Pretreatment HEV polymerase mutations and de novo mutations under ribavirin did not have a negative impact on HEV clearance. Anemia was the main adverse event. Conclusions This large-scale retrospective study confirms that ribavirin is highly efficient for treating chronic HEV infection in SOT recipients and shows that the predominant HEV RNA polymerase mutations found in this study do not affect the rate of HEV clearance. This large-scale retrospective study that included 255 solid organ transplant recipients confirms that ribavirin is highly efficient for treating chronic hepatitis E virus (HEV) infection and shows that HEV RNA polymerase mutations do not play a role in HEV clearance.

Published
2020
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40. Factors affecting outcomes following pelvic exenteration for locally recurrent rectal cancer

Author

Kelly M. E., Glynn R., Aalbers A. G. J., Abraham-Nordling M., Alberda W., Antoniou A., Austin K. K., Beets G. L., Beynon J., Bosman S. J., Brunner M., Buchler M. W., Burger J. W. A., Campain N., Christensen H. K., Codd M., Coscia M., Colquhoun A. J., Daniels I. R., Davies R. J., de Wilt J. H. W., Deutsch C., Dietz D., Eglinton T., Fearnhead N., Frizelle F. A., Garcia-Sabrido J. L., George M. L., Gentilini L., Harris D. A., Harji D., Heriot A. G., Hohenberger Brunner W., Jenkins J. T., Kanemitsu Y., Chan K. K. L., Kim H., Koh C. E., Kok N. F., Kontovounisios C., Kulu Y., Law W. L., Le G. N., Lee P., Lydrup M. L., Lynch A. C., Martling A., Meijerink J., Merkel S., McDermott F. D., McGrath J. S., Nielsen Christensen M. B., Nieuwenhuijzen G. A. P., Nordling M. A., Northover J. M. A., O'Connell P. R., Patsouras D., Poggioli G., Radwan R. W., Rasheed S., Rasmussen P. C., Rothbarth J., Rutten H. J. T., Sagar P. M., Schizas A. M. P., Shida D., Smart N. J., Solomon M. J., Stocchi L., Tekkis P. P., Tsukamoto S., Turner W. H., Tuynman J., Ulrich A., van Leeuwenhoek A., van Ramshorst G. H., Vasquez-Jimenez W., Verhoef C., Versteegen M., Wakeman C., Warrier S., Yip J., Winter D. C., Surgery, Kelly M.E., Glynn R., Aalbers A.G.J., Abraham-Nordling M., Alberda W., Antoniou A., Austin K.K., Beets G.L., Beynon J., Bosman S.J., Brunner M., Buchler M.W., Burger J.W.A., Campain N., Christensen H.K., Codd M., Coscia M., Colquhoun A.J., Daniels I.R., Davies R.J., de Wilt J.H.W., Deutsch C., Dietz D., Eglinton T., Fearnhead N., Frizelle F.A., Garcia-Sabrido J.L., George M.L., Gentilini L., Harris D.A., Harji D., Heriot A.G., Hohenberger Brunner W., Jenkins J.T., Kanemitsu Y., Chan K.K.L., Kim H., Koh C.E., Kok N.F., Kontovounisios C., Kulu Y., Law W.L., Le G.N., Lee P., Lydrup M.L., Lynch A.C., Martling A., Meijerink J., Merkel S., McDermott F.D., McGrath J.S., Nielsen Christensen M.B., Nieuwenhuijzen G.A.P., Nordling M.A., Northover J.M.A., O'Connell P.R., Patsouras D., Poggioli G., Radwan R.W., Rasheed S., Rasmussen P.C., Rothbarth J., Rutten H.J.T., Sagar P.M., Schizas A.M.P., Shida D., Smart N.J., Solomon M.J., Stocchi L., Tekkis P.P., Tsukamoto S., Turner W.H., Tuynman J., Ulrich A., van Leeuwenhoek A., van Ramshorst G.H., Vasquez-Jimenez W., Verhoef C., Versteegen M., Wakeman C., Warrier S., Yip J., Winter D.C., AGEM - Re-generation and cancer of the digestive system, and CCA - Cancer Treatment and quality of life

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, 030230 surgery, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 03 medical and health sciences, 0302 clinical medicine, SDG 3 - Good Health and Well-being, medicine, Clinical endpoint, Humans, Survival rate, Survival analysis, Neoadjuvant therapy, Aged, Rectal Neoplasm, Pelvic exenteration, Rectal Neoplasms, business.industry, Odds ratio, Middle Aged, Survival Analysis, Neoadjuvant Therapy, Pelvic Exenteration, Surgery, Radiation therapy, Treatment Outcome, 030220 oncology & carcinogenesis, Resection margin, Female, Survival Analysi, Neoplasm Recurrence, Local, business, Human
Abstract

Background Pelvic exenteration for locally recurrent rectal cancer (LRRC) is associated with variable outcomes, with the majority of data from single-centre series. This study analysed data from an international collaboration to determine robust parameters that could inform clinical decision-making. Methods Anonymized data on patients who had pelvic exenteration for LRRC between 2004 and 2014 were accrued from 27 specialist centres. The primary endpoint was survival. The impact of resection margin, bone resection, node status and use of neoadjuvant therapy (before exenteration) was assessed. Results Of 1184 patients, 614 (51·9 per cent) had neoadjuvant therapy. A clear resection margin (R0 resection) was achieved in 55·4 per cent of operations. Twenty-one patients (1·8 per cent) died within 30 days and 380 (32·1 per cent) experienced a major complication. Median overall survival was 36 months following R0 resection, 27 months after R1 resection and 16 months following R2 resection (P < 0·001). Patients who received neoadjuvant therapy had more postoperative complications (unadjusted odds ratio (OR) 1·53), readmissions (unadjusted OR 2·33) and radiological reinterventions (unadjusted OR 2·12). Three-year survival rates were 48·1 per cent, 33·9 per cent and 15 per cent respectively. Bone resection (when required) was associated with a longer median survival (36 versus 29 months; P < 0·001). Node-positive patients had a shorter median overall survival than those with node-negative disease (22 versus 29 months respectively). Multivariable analysis identified margin status and bone resection as significant determinants of long-term survival. Conclusion Negative margins and bone resection (where needed) were identified as the most important factors influencing overall survival. Neoadjuvant therapy before pelvic exenteration did not affect survival, but was associated with higher rates of readmission, complications and radiological reintervention.

Published
2018
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43. Neural alterations in surgical stage chronic pancreatitis are independent of the underlying aetiology. (Pancreatitis)

Author

Friess, H., Shrikhande, S., Shrikhande, M., Martignoni, M., Kulli, C., Zimmermann, A., Kappeler, A., Ramesh, H., and Buchler, M.

Subjects
Pancreatitis -- Causes of, Health, Causes of
Abstract

Background and aims: Among various causes, nerve alterations and neuroimmune interactions have been suggested to participate in the generation of pain in chronic pancreatitis (CP). In this study, we compared [...]

Published
2002

45. TNM Staging of Neoplasms of the Endocrine Pancreas: Results From a Large International Cohort Study

Author

Rindi, G., Falconi, M., Klersy, C., Albarello, L., Boninsegna, L., Buchler, M. W., Capella, C., Caplin, M., Couvelard, A., Doglioni, C., Delle Fave, G., Fischer, L., Fusai, G., de Herder, W. W., Jann, H., Komminoth, P., de Krijger, R. R., La Rosa, S., Luong, T. V., Pape, U., Perren, A., Ruszniewski, P., Scarpa, A., Schmitt, A., Solcia, E., and Wiedenmann, B.

Published
2012
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48. ESPAC-5F: Four arm, international randomised phase II trial of immediate surgery compared with neoadjuvant gemcitabine plus capecitabine (GEMCAP) or FOLFIRINOX or chemoradiotherapy (CRT) in patients with borderline resectable pancreatic cancer

Author

Ghaneh, P., primary, Palmer, D., additional, Cicconi, S., additional, Halloran, C., additional, Psarelli, E., additional, Rawcliffe, C., additional, Sripadam, R., additional, Mukherjee, S., additional, Wadsley, J., additional, Al-Mukhtar, A., additional, Jiao, L., additional, Wasan, H., additional, Carter, R., additional, Graham, J., additional, Ammad, F., additional, Evans, J., additional, Tjaden, C., additional, Hackert, T., additional, Buchler, M., additional, and Neoptolemos, J., additional

Published
2020
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49. ESPAC-4: A randomized controlled phase III trial of adjuvant gemcitabine (GEM) and capecitabine (CAP) versus gemcitabine in resected pancreatic ductal adenocarcinoma: five year follow up.

Author

Neoptolemos, J., primary, Palmer, D., additional, Gahneh, P., additional, Valle, J., additional, Cunningham, D., additional, Wadsley, J., additional, Meyer, T., additional, Anthoney, A., additional, Glimelius, B., additional, Falk, S., additional, Segersvard, R., additional, Middleton, G., additional, Ross, P., additional, Wasan, H., additional, Mcdonald, A., additional, Crosby, T., additional, Psarelli, E., additional, Hammel, P., additional, Hackert, T., additional, Halloran, C., additional, and Buchler, M., additional

Published
2020
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