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2. In-vivo and pre-treatment quality assurance software validation and verification

Author

Vanzi, E., Reversi, L., Giani, G., Arilli, C., Bonomo, P., Casati, M., Compagnucci, A., Greto, D., Marrazzo, L., Scoccianti, S., Pallotta, S., Bucciolini, M., Talamonti, C., MAGJAREVIC, Ratko, Editor-in-chief, Ladyzynsk, Piotr, Series editor, Ibrahim, Fatimah, Series editor, Lacković, Igor, Series editor, Rock, Emilio Sacristan, Series editor, and Jaffray, David A., editor

Published
2015
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6. Towards a proton imaging system

Author

Civinini, C., Brianzi, M., Bruzzi, M., Bucciolini, M., Candiano, G., Capineri, L., Cirrone, G.A.P., Cuttone, G., Lo Presti, D., Marrazzo, L., Mazzaglia, E., Menichelli, D., Pieri, S., Randazzo, N., Sipala, V., Stancampiano, C., Talamonti, C., Tesi, M., and Valentini, S.

Published
2010
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9. Proton radiography for clinical applications

Author

Talamonti, C., Reggioli, V., Bruzzi, M., Bucciolini, M., Civinini, C., Marrazzo, L., Menichelli, D., Pallotta, S., Randazzo, N., Sipala, V., Cirrone, G.A.P., Petterson, M., Blumenkrantz, N., Feldt, J., Heimann, J., Lucia, D., Seiden, A., Williams, D.C., Sadrozinski, H.F.-W., Bashkirov, V., and Schulte, R.

Published
2010
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13. The Italian project for a proton imaging device

Author

Cirrone, G.A.P., Candiano, G., Cuttone, G., Lo Nigro, S., Lo Presti, D., Randazzo, N., Sipala, V., Russo, M., Aiello, S., Bruzzi, M., Menichelli, D., Scaringella, M., Miglio, S., Bucciolini, M., Talamonti, C., and Pallotta, S.

Published
2007
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26. Design and characterisation of a YAG(Ce) calorimeter for proton Computed Tomography application

Author

Sipala, V, Randazzo, N, Aiello, S, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Leonora, E, Lo Presti, D, Pallotta, S, Pugliatti, C, Scaringella, M, Stancampiano, C, Talamonti, C, Vanzi, E, SIPALA, Valeria, Randazzo, N., Aiello, S., Bruzzi, M., Bucciolini, M., CARPINELLI, Massimo, Cirrone, G. A. P., Civinini, C., Cuttone, G., Leonora, E., Lo Presti, D., Pallotta, S., Pugliatti, C., Scaringella, M., Stancampiano, C., Talamonti, C., Vanzi, E., Sipala, V, Randazzo, N, Aiello, S, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Leonora, E, Lo Presti, D, Pallotta, S, Pugliatti, C, Scaringella, M, Stancampiano, C, Talamonti, C, Vanzi, E, SIPALA, Valeria, Randazzo, N., Aiello, S., Bruzzi, M., Bucciolini, M., CARPINELLI, Massimo, Cirrone, G. A. P., Civinini, C., Cuttone, G., Leonora, E., Lo Presti, D., Pallotta, S., Pugliatti, C., Scaringella, M., Stancampiano, C., Talamonti, C., and Vanzi, E.

Abstract

The design and the characterization of a calorimeter system, aimed at measuring the residual energy in a proton Computed Tomography (pCT) apparatus, is described. The calorimeter has a 6×6cm2 active area to fully cover the tracker area of the pCT system, being 10 cm thick it is able to stop up to 200 MeV protons and sustain 1MHz particle rate (average rate on the whole area). The YAG(Ce) scintillator is promising for charged particle detection applications where high-count rate, good energy resolution and compact photodiode readout, not influenced by magnetic fields, are of importance. The aim of this work is to show data acquired with proton beam energy up to 175 MeV and to discuss the performances of this calorimeter.

Published
2015

27. A proton Computed Tomography based medical imaging system

Author

Scaringella, M, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Sipala, V, Stancampiano, C, Talamonti, C, Vanzi, E, Zani, M, Scaringella M., Bruzzi M., Bucciolini M., CARPINELLI, Massimo, Cirrone G. A. P., Civinini C., Cuttone G., Lo Presti D., Pallotta S., Pugliatti C., Randazzo N., Romano F., SIPALA, Valeria, Stancampiano C., Talamonti C., Vanzi E., Zani M., Scaringella, M, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Sipala, V, Stancampiano, C, Talamonti, C, Vanzi, E, Zani, M, Scaringella M., Bruzzi M., Bucciolini M., CARPINELLI, Massimo, Cirrone G. A. P., Civinini C., Cuttone G., Lo Presti D., Pallotta S., Pugliatti C., Randazzo N., Romano F., SIPALA, Valeria, Stancampiano C., Talamonti C., Vanzi E., and Zani M.

Abstract

This paper reports on the activity of the INFN PRIMA/RDH collaboration in the development of proton Computed Tomography (pCT) systems based on single proton tracking and residual energy measurement. The systems are made of a silicon microstrip tracker and a YAG:Ce crystal calorimeter to measure single protons trajectory and residual energy, respectively. A first prototype of pCT scanner, with an active area of about 5 × 5 cm2 and a data rate capability of 10 kHz, has been constructed and characterized with 62 MeV protons at INFN Laboratori Nazionali del Sud in Catania (Italy) and with 180 MeV protons at The Svedberg Laboratory (TSL) in Uppsala (Sweden). Results of these measurements, including tomographic reconstructions of test phantoms, will be shown and discussed. An upgraded system with an extended field of view (up to ∼ 5 × 20 cm2) and an increased event rate capability up to one MHz, presently under development, will be also described.

Published
2014

28. Characterization of a YAG:Ce calorimeter with high-energy proton beam

Author

Sipala, V, Randazzo, N, Aiello, S, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Leonora, E, Lo Presti, D, Pallotta, S, Scaringella, M, Stancampiano, C, Talamonti, C, Vanzi, E, SIPALA, Valeria, Randazzo, N., Aiello, S., Bruzzi, M., Bucciolini, M., CARPINELLI, Massimo, Cirrone, G. A. P., Civinini, C., Cuttone, G., Leonora, E., Lo Presti, D., Pallotta, S., Scaringella, M., Stancampiano, C., Talamonti, C., Vanzi, E., Sipala, V, Randazzo, N, Aiello, S, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Leonora, E, Lo Presti, D, Pallotta, S, Scaringella, M, Stancampiano, C, Talamonti, C, Vanzi, E, SIPALA, Valeria, Randazzo, N., Aiello, S., Bruzzi, M., Bucciolini, M., CARPINELLI, Massimo, Cirrone, G. A. P., Civinini, C., Cuttone, G., Leonora, E., Lo Presti, D., Pallotta, S., Scaringella, M., Stancampiano, C., Talamonti, C., and Vanzi, E.

Abstract

A YAG:Ce calorimeter with a 6×6 cm2 active area, long 10 cm has been manufactured in order to stop up to 200 MeV protons and to sustain 1MHz particle rate. It consists of four optically separated crystals assembled in the same housing. The YAG:Ce scintillator is promising for charged particle detection applications where high-count rate, good energy resolution and compact photodiode readout, not influenced by magnetic fields, are of importance. The YAG:Ce calorimeter has been characterized with proton beams up to 175MeV a The Svedberg Laboratory (TSL), Uppsala Sweden. Results obtained are shown and discussed.

Published
2014

30. The PRIMA (PRoton IMAging) collaboration: Development of a proton Computed Tomography apparatus

Author

Scaringella, M, Brianzi, M, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Sipala, V, Stancampiano, C, Talamonti, C, Tesi, M, Vanzi, E, Zani, M, Scaringella M, Brianzi M, Bruzzi M, Bucciolini M, CARPINELLI, Massimo, Cirrone GAP, Civinini C, Cuttone G, Lo Presti D, Pallotta S, Pugliatti C, Randazzo N, Romano F, SIPALA, Valeria, Stancampiano C, Talamonti C, Tesi M, Vanzi E, Zani M., Scaringella, M, Brianzi, M, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Sipala, V, Stancampiano, C, Talamonti, C, Tesi, M, Vanzi, E, Zani, M, Scaringella M, Brianzi M, Bruzzi M, Bucciolini M, CARPINELLI, Massimo, Cirrone GAP, Civinini C, Cuttone G, Lo Presti D, Pallotta S, Pugliatti C, Randazzo N, Romano F, SIPALA, Valeria, Stancampiano C, Talamonti C, Tesi M, Vanzi E, and Zani M.

Abstract

This paper describes the development of a proton Computed Tomography (pCT) apparatus able to reconstruct a map of stopping power useful for accurate proton therapy treatment planning and patient positioning. This system is based on two main components: a silicon microstrip tracker and a YAG:Ce crystal calorimeter. Each proton trajectory is sampled by the tracker in four points: two upstream and two downstream the object under test; the particle residual energy is measured by the calorimeter. The apparatus is described in details together with a discussion on the characterization of the hardware under proton beams with energies up to 175 MeV.

Published
2013

31. A proton Computed Tomography system for medical applications

Author

Sipala, V, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Scaringella, M, Stancampiano, C, Talamonti, C, Tesi, M, Vanzi, E, Zani, M, SIPALA, Valeria, Bruzzi M, Bucciolini M, CARPINELLI, Massimo, Cirrone GAP, Civinini C, Cuttone G, Lo Presti D, Pallotta S, Pugliatti C, Randazzo N, Romano F, Scaringella M, Stancampiano C, Talamonti C, Tesi M, Vanzi E, Zani M., Sipala, V, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Scaringella, M, Stancampiano, C, Talamonti, C, Tesi, M, Vanzi, E, Zani, M, SIPALA, Valeria, Bruzzi M, Bucciolini M, CARPINELLI, Massimo, Cirrone GAP, Civinini C, Cuttone G, Lo Presti D, Pallotta S, Pugliatti C, Randazzo N, Romano F, Scaringella M, Stancampiano C, Talamonti C, Tesi M, Vanzi E, and Zani M.

Abstract

Proton Computed Tomography (pCT) can improve the accuracy of both patient positioning and dose calculation in proton therapy, enabling to accurately reconstruct the electron density distribution of irradiated tissues. A pCT prototype, equipped with a silicon tracker and a YAG:Ce calorimeter, has been manufactured by an Italian collaboration. First tests under proton beam allowed obtaining good quality tomographic images of a non-homogeneous phantom. Manufacturing of a new large area system with real-time data acquisition is under way.

Published
2013

32. Recent results on the development of a proton computed tomography system

Author

Civinini, C, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Scaringella, M, Sipala, V, Stancampiano, C, Talamonti, C, Vanzi, E, Zani, M, Civinini C, Bruzzi M, Bucciolini M, CARPINELLI, Massimo, Cirrone GAP, Cuttone G, Lo Presti D, Pallotta S, Pugliatti C, Randazzo N, Romano F, Scaringella M, SIPALA, Valeria, Stancampiano C, Talamonti C, Vanzi E, Zani M., Civinini, C, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Scaringella, M, Sipala, V, Stancampiano, C, Talamonti, C, Vanzi, E, Zani, M, Civinini C, Bruzzi M, Bucciolini M, CARPINELLI, Massimo, Cirrone GAP, Cuttone G, Lo Presti D, Pallotta S, Pugliatti C, Randazzo N, Romano F, Scaringella M, SIPALA, Valeria, Stancampiano C, Talamonti C, Vanzi E, and Zani M.

Abstract

Proton Computed Tomography (pCT) is a medical imaging technique based on the use of proton beams with energies above 200 MeV to directly measure stopping power distributions inside the tissue volume. Prima (PRoton IMAging) is an Italian collaboration working on the development of a pCT scanner based on a tracker and a calorimeter to measure single protons trajectory and residual energy. The tracker is composed of four planes of silicon microstrip detectors to measure proton entry and exit positions and angles. Residual energy is measured by a calorimeter composed of YAG:Ce scintillating crystals. A first prototype of pCT scanner, with an active area of about 5×5 cm2, has been constructed and characterized with 60 MeV protons at the INFN Laboratori Nazionali del Sud, Catania (Italy) and with 180 MeV protons at Svedberg Laboratory, Uppsala (Sweden). A new pre-clinical prototype with an extended active area up to 20×5 cm2, real time data acquisition and a data rate up to 1 MHz is under development. A description of the two prototypes will be presented together with first results concerning tomographic image reconstruction.

Published
2013

33. Towards a large area apparatus for Proton Computed Tomography

Author

Bruzzi, M, Brianzi, M, Bucciolini, M, Carpinelli, M, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Scaringella, M, Sipala, V, Stancampiano, C, Talamonti, C, Tesi, M, Vanzi, E, Zani, M, Bruzzi, M., Brianzi, M., Bucciolini, M., CARPINELLI, Massimo, Civinini, C., Cuttone, G., Lo Presti, D., Pallotta, S., Pugliatti, C., Randazzo, N., Romano, F., Scaringella, M., SIPALA, Valeria, Stancampiano, C., Talamonti, C., Tesi, M., Vanzi, E., Zani, M., Bruzzi, M, Brianzi, M, Bucciolini, M, Carpinelli, M, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Scaringella, M, Sipala, V, Stancampiano, C, Talamonti, C, Tesi, M, Vanzi, E, Zani, M, Bruzzi, M., Brianzi, M., Bucciolini, M., CARPINELLI, Massimo, Civinini, C., Cuttone, G., Lo Presti, D., Pallotta, S., Pugliatti, C., Randazzo, N., Romano, F., Scaringella, M., SIPALA, Valeria, Stancampiano, C., Talamonti, C., Tesi, M., Vanzi, E., and Zani, M.

Abstract

Proton Computed Tomography (pCT) is a new imaging method with a potential for increasing accuracy of treatment planning and patient positioning in hadron therapy. A pCT system with small active area (5cm×5cm) has been already manufactured by authors. Tested under proton beams gave first promising results on radiography and tomographic reconstructions. Recent developments of a second prototype with large area (5×20cm2) in the perspective of a pre-clinical acquisition system is now being designed, details are given in this paper.

Published
2013

34. The PRIMA (Proton Imaging) collaboration: Status of the development of a proton Computed Tomography Scanner

Author

Bruzzi, M, Brianzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Sipala, V, Scaringella, M, Stancampiano, C, Talamonti, C, Tesi, M, Vanzi, E, Zani, M, Bruzzi M, Brianzi M, Bucciolini M, CARPINELLI, Massimo, Cirrone GAP, Civinini C, Cuttone G, Lo Presti D, Pallotta S, Pugliatti C, Randazzo N, Romano F, SIPALA, Valeria, Scaringella M, Stancampiano C, Talamonti C, Tesi M, Vanzi E, Zani M., Bruzzi, M, Brianzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Sipala, V, Scaringella, M, Stancampiano, C, Talamonti, C, Tesi, M, Vanzi, E, Zani, M, Bruzzi M, Brianzi M, Bucciolini M, CARPINELLI, Massimo, Cirrone GAP, Civinini C, Cuttone G, Lo Presti D, Pallotta S, Pugliatti C, Randazzo N, Romano F, SIPALA, Valeria, Scaringella M, Stancampiano C, Talamonti C, Tesi M, Vanzi E, and Zani M.

Abstract

The PRIMA (Proton IMAging) experiment is aimed at developing a proton Computed Tomography (pCT) prototype based on tracking single protons. Approaches to the pCT consist in the use of silicon microstrip detectors to measure the position and direction of individual protons before and after they traverse the phantom, in view to reconstruct the trajectory of each proton, and a calorimeter for measuring particle residual energy. A small prototype was tested, under 62 MeV proton beam at Laboratory Nazionali del Sud, (Catania Italy) and under 180 MeV proton beam at Svedberg Laboratories, Uppsala Universitet, (Uppsala Sweden). Several experiments concerning proton imaging, tomography and radiography, were carried out during these beam tests. Radiographies have been reconstructed with different methods: results show the good performances of the device, with spatial resolution fulfilling the stringent requirements of a pCT device.

Published
2012

35. Development of a Proton Computed Tomography System for Pre-Clinical Tests

Author

Civinini, C, Brianzi, M, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Scaringella, M, Sipala, V, Stancampiano, C, Talamonti, C, Tesi, M, Vanzi, E, Zani, M, Civinini C, Brianzi M, Bruzzi M, Bucciolini M, CARPINELLI, Massimo, Cirrone GAP, Cuttone G, Lo Presti D, Pallotta S, Pugliatti C, Randazzo N, Romano F, Scaringella M, SIPALA, Valeria, Stancampiano C, Talamonti C, Tesi M, Vanzi E, Zani M., Civinini, C, Brianzi, M, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Scaringella, M, Sipala, V, Stancampiano, C, Talamonti, C, Tesi, M, Vanzi, E, Zani, M, Civinini C, Brianzi M, Bruzzi M, Bucciolini M, CARPINELLI, Massimo, Cirrone GAP, Cuttone G, Lo Presti D, Pallotta S, Pugliatti C, Randazzo N, Romano F, Scaringella M, SIPALA, Valeria, Stancampiano C, Talamonti C, Tesi M, Vanzi E, and Zani M.

Abstract

Proton Computed Tomography (pCT) is an imaging method under investigation with the aim to improve the accuracy of treatment planning and patient positioning in hadron therapy. A pCT system should be capable to measure tissue electron density with an accuracy better than 1% and with a spatial resolution better than 1mm. A first apparatus based on a silicon tracker and a YAG:Ce crystal calorimeter, with a 5×5 cm2 active area, has been already developed by the authors in the framework of the PRIMA (Proton Imaging) collaboration and tested with proton beams with promising results. A second prototype with larger area (5×20 cm2) and improved data acquisition system is being designed. The details about this new prototype will be presented in this work.

Published
2012

36. PRIMA Proton Imaging for Clinical Application

Author

Talamonti, C, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Randazzo, N, Romano, F, Scaringella, M, Sipala, V, Stancampiano, C, Vanzi, E, Zani, M, Talamonti C, Bruzzi M, Bucciolini M, CARPINELLI, Massimo, Cirrone GAP, Civinini C, Cuttone G, Lo Presti D, Pallotta S, Randazzo N, Romano F, Scaringella M, SIPALA, Valeria, Stancampiano C, Vanzi E, Zani M., Talamonti, C, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Randazzo, N, Romano, F, Scaringella, M, Sipala, V, Stancampiano, C, Vanzi, E, Zani, M, Talamonti C, Bruzzi M, Bucciolini M, CARPINELLI, Massimo, Cirrone GAP, Civinini C, Cuttone G, Lo Presti D, Pallotta S, Randazzo N, Romano F, Scaringella M, SIPALA, Valeria, Stancampiano C, Vanzi E, and Zani M.

Abstract

PRIMA project is an Italian project funded by INFN and MIUR (PRIN 2006), which developed a proton Computed Tomography (pCT) prototype based on tracking the single proton. PRIMA approaches to the pCT consist in the use of silicon detectors, which measure the energy and position of individual protons before and after they traverse the object. The device consists of a silicon microstrip tracker, used to reconstruct the trajectory of each proton, and a calorimeter that measure the particle residual energy. It is characterized by an active area of 5 × 5 cm2 and by an acquisition rate of 10kHz. PRIMA prototype was tested, under 62 MeV proton beam at Laboratory Nazionali del Sud, (Catania Italy) and under 180 MeV proton beam at Svedberg Laboratories, Uppsala Universitet, (Uppsala Sweden). Several experiments concerning proton imaging, tomography and radiography images, were carried out during these beam tests. In particular in this paper will be reported the PRIMA experience on the data acquired using special phantoms. The performed tests aimed to evaluate the clinical applicability of proton radiography in terms of image quality. In order to test spatial resolution, electron density resolution and energy resolution of the system, PRIMA group has developed suitable phantoms for radiography. The phantoms are custom-made and suitable for high-contrast spatial resolution. They are PolyMetilMetacrilate (PMMA) cylinders with holes of different size and depth. In particular, the phantom diameter was chosen accordingly with the tracker field of view while the phantom length depends on the beam quality: it was 20mm and 150mm for 60MeV and 180MeV proton beam respectively. In this paper the experimental setup will be described, radiographic images will be shown and quantitative results on spatial resolution will be reported.

Published
2012

37. The PRIMA (Proton Imaging) collaboration: Status of the development of a proton Computed Tomography Scanner

Author

Bruzzi M, Brianzi M, Bucciolini M, CARPINELLI, Massimo, Cirrone GAP, Civinini C, Cuttone G, Lo Presti D, Pallotta S, Pugliatti C, Randazzo N, Romano F, SIPALA, Valeria, Scaringella M, Stancampiano C, Talamonti C, Tesi M, Vanzi E, Zani M., Bruzzi, M, Brianzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Sipala, V, Scaringella, M, Stancampiano, C, Talamonti, C, Tesi, M, Vanzi, E, and Zani, M

Subjects
Spatial resolution, Silicon detector, Proton computed tomography (pCT), Network security, Proton computed tomography, Computerized tomography, Proton beam, Radiography, Silicon micro-strip detector, Experiment, Nuclear physic, Residual energy, Medical imaging, Proton, Proton imaging, Stringent requirement, Data privacy, Beam test
Abstract

The PRIMA (Proton IMAging) experiment is aimed at developing a proton Computed Tomography (pCT) prototype based on tracking single protons. Approaches to the pCT consist in the use of silicon microstrip detectors to measure the position and direction of individual protons before and after they traverse the phantom, in view to reconstruct the trajectory of each proton, and a calorimeter for measuring particle residual energy. A small prototype was tested, under 62 MeV proton beam at Laboratory Nazionali del Sud, (Catania Italy) and under 180 MeV proton beam at Svedberg Laboratories, Uppsala Universitet, (Uppsala Sweden). Several experiments concerning proton imaging, tomography and radiography, were carried out during these beam tests. Radiographies have been reconstructed with different methods: results show the good performances of the device, with spatial resolution fulfilling the stringent requirements of a pCT device.

Published
2012

38. PRIMA Proton Imaging for Clinical Application

Author

Talamonti C, Bruzzi M, Bucciolini M, CARPINELLI, Massimo, Cirrone GAP, Civinini C, Cuttone G, Lo Presti D, Pallotta S, Randazzo N, Romano F, Scaringella M, SIPALA, Valeria, Stancampiano C, Vanzi E, Zani M., Talamonti, C, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Randazzo, N, Romano, F, Scaringella, M, Sipala, V, Stancampiano, C, Vanzi, E, and Zani, M

Subjects
Spatial resolution, Silicon microstrip tracker, Radiographic image, Proton computed tomography (pCT), Radiography image, Network security, Computerized tomography, Optical microscopy, Clinical application, Proton beam, Radiography, Image resolution, Polymethyl methacrylate, Nuclear physic, Quantitative result, Medical imaging, Proton, Energy resolution, Data privacy
Abstract

PRIMA project is an Italian project funded by INFN and MIUR (PRIN 2006), which developed a proton Computed Tomography (pCT) prototype based on tracking the single proton. PRIMA approaches to the pCT consist in the use of silicon detectors, which measure the energy and position of individual protons before and after they traverse the object. The device consists of a silicon microstrip tracker, used to reconstruct the trajectory of each proton, and a calorimeter that measure the particle residual energy. It is characterized by an active area of 5 × 5 cm2 and by an acquisition rate of 10kHz. PRIMA prototype was tested, under 62 MeV proton beam at Laboratory Nazionali del Sud, (Catania Italy) and under 180 MeV proton beam at Svedberg Laboratories, Uppsala Universitet, (Uppsala Sweden). Several experiments concerning proton imaging, tomography and radiography images, were carried out during these beam tests. In particular in this paper will be reported the PRIMA experience on the data acquired using special phantoms. The performed tests aimed to evaluate the clinical applicability of proton radiography in terms of image quality. In order to test spatial resolution, electron density resolution and energy resolution of the system, PRIMA group has developed suitable phantoms for radiography. The phantoms are custom-made and suitable for high-contrast spatial resolution. They are PolyMetilMetacrilate (PMMA) cylinders with holes of different size and depth. In particular, the phantom diameter was chosen accordingly with the tracker field of view while the phantom length depends on the beam quality: it was 20mm and 150mm for 60MeV and 180MeV proton beam respectively. In this paper the experimental setup will be described, radiographic images will be shown and quantitative results on spatial resolution will be reported.

Published
2012

39. Characterization of CVD Diamond Films as Radiation Detectors for Dosimetric Applications

Author

Bruzzi, M., Bucciolini, M., Cirrone, G.A.P., Cuttone, G., Guasti, A., Mazzocchi, S., Pirollo, S., Sabini, M.G., and Sciortino, S.

Subjects
Radiotherapy -- Equipment and supplies, Business, Electronics, Electronics and electrical industries
Abstract

The possibilitiy of using CVD diamond films as dosimeters in radiotherapy applications has been tested in both off-line and on-line configurations. The ThermoLuminescent and Thermally Stimulated Current responses after 20MeV electron and 22 MeV proton irradiation have been studied as a function of the dose up to 10 Gy. CVD Diamond compares favourably with standard off-line LiF dosimeters. In on-line configuration, detector-grade high-purity CVD diamond shows a sensitivity almost four order of magnitude higher than that of ionisation chambers.

Published
2000

45. PRIMA+: A proton Computed Tomography apparatus

Author

Civinini, C., Bruzzi, M., Bucciolini, M., Cirrone, G. A. P., Cuttone, G., Lo Presti, D., Pallotta, S., Randazzo, N., Scaringella, M., Sipala, V., Stancampiano, C., Talamonti, C., Tesi, M., Vanzi, E., and Zani, M.

Published
2013

48. Proton imaging apparatus for protontherapy application

Author

Sipala, V., Brianzi, M., Bruzzi, M., Bucciolini, M., Cirrone, G. A. P., Civinini, C., Cuttone, G., LO PRESTI, Domenico, Randazzo, N., Scaringella, M., Stancampiano, C., Talamonti, C., and Tesi, M.

Published
2011

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