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BACKGROUND: Development of capsular contracture around subcutaneously implanted breast prostheses, producing poor cosmetic outcome and pain, has been reported following standard fractionated external beam radiotherapy to whole implants for breast cancer. We report capsular contracture following partial implant irradiation from hypofractionated stereotactic body radiotherapy (SBRT) for lung cancer in a 64 year-old female with augmentation mammaplasty. METHODS: The patient had biopsy-proven, T1 non-small cell lung carcinoma, adjacent to the implant. She received 50 Gy in 4 fractions to 91% of planning target volume using a 7-field, 3D-conformal plan with 6 MV photons and daily CT-guided target localization. The implant received 9.3 Gy mean dose, 51.7 Gy maximum point dose, with V10 41%, V20 15% and V30 4%. RESULTS: At seven months, the patient reported left breast pain requiring narcotic analgesics and demonstrated modified Baker/Palmer grade 4 capsular contracture. Breast retraction assessment measurement increased from baseline 10.4 mm to 19.8 mm. CONCLUSIONS: This represents the first reported case of capsular contracture from partial breast implant radiation following SBRT for lung cancer. Further investigation to elucidate maximum tolerated dose of radiation given to breast implants in this setting is needed. [ABSTRACT FROM AUTHOR]

We examined our institution's experience with 22 cases of previously untreated buccal squamous cell carcinoma via a retrospective chart review. Eleven of these patients had been treated with a combination of surgical excision and postoperative radiation therapy, 8 patients with surgical excision alone, and 3 patients with radiation therapy alone. The overall 3-year locoregional recurrence rate was 32% (n = 7). The 3-year survival rates were 82% after surgery plus radiation (9 of 11 patients), 63% after surgery alone (5 of 8), and 33% after radiation alone (1 of 3). Three-year T-category--specific survival rates were 100% for category T1 tumors (3 of 3 patients), 73% for T2 (8 of 11), 50% for T3 (3 of 6), and 50% for T4 (1 of 2). Although the small size of our study precluded any statistically significant conclusions, we believe that locoregional control and survival rates may be greater with surgical excision plus postoperative radiation than with treatment with either modality alone. [ABSTRACT FROM AUTHOR]

Background. The optimal treatment for patients with locally recurrent carcinomas of the salivary glands is unclear. Methods. Ninety-nine patients underwent salvage surgery for locally recurrent salivary gland carcinomas. Eighty-one (82%) had previously received radiation. Thirty-seven patients (37%) received intraoperative radiation therapy (IORT) to a median dose of 15 Gy (range, 12–18 Gy) at the time of salvage. Results. The 1-, 3-, and 5-year estimates of local control after salvage surgery were 88%, 75%, and 69%, respectively. A Cox proportional hazard model identified positive margins (0.01) and the omission of IORT (p = .001) as independent predictors of local failure. The 5-year overall survival was 34%. Distant metastasis was the most common site of subsequent failure, occurring in 42% of patients. Conclusions. IORT significantly improves disease control for patients with locally recurrent carcinomas of the salivary glands. The high rate of distant metastasis emphasizes the need for effective systemic therapies. © 2007 Wiley Periodicals, Inc. Head Neck, 2008 [ABSTRACT FROM AUTHOR]

Objective: To assess the value of planned neck dissection in patients with a complete response to definitive radiotherapy for squamous cell carcinoma of the tonsillar fossa with advanced nodal disease., Design: Case series., Setting: Academic tertiary care medical center., Patients: A consecutive series of 36 patients with squamous cell carcinoma of the tonsillar fossa with N2 or N3 nodal disease treated with primary radiation therapy with or without concurrent chemotherapy between January 1, 1992, and April 1, 2003, at the University of California, San Francisco, Comprehensive Cancer Center. Patients treated with primary surgery, those treated with palliative intent, or those with preexisting malignancies were excluded., Main Outcome Measures: Regional control and overall survival., Results: Of the study group, 15 patients (42%) achieved a complete response, 17 (47%) achieved a partial response, and 1 (3%) was a nonresponder. The response in 3 patients (8%) could not be assessed. Of the 15 patients with a complete response, only 2 (13%) later developed regional recurrences, 1 of which was an isolated recurrence in the neck. Regional control and overall survival at 3 years were 78% and 48%, respectively., Conclusions: The rate of regional recurrence after a complete response to radiation therapy with or without concurrent chemotherapy for tonsillar squamous cell carcinoma with advanced cervical metastases is low. Our results support close surveillance of the neck in those who have achieved a complete response after radiation therapy with or without chemotherapy.