Search

Your search keyword '"Bucala, Richard J."' showing total 25 results
Start Over Author "Bucala, Richard J."
25 results on '"Bucala, Richard J."'

16. Deletion of Macrophage Migration Inhibitory Factor Reduces Severity of Osteoarthritis in Aged Mice

Author

Rowe, Meredith A., Harper, Lindsey R., McNulty, Margaret A., Lau, Anthony G., Carlson, Cathy S., Leng, Lin, Bucala, Richard J., Miller, Richard A., and Loeser, Richard F.

Subjects
Intramolecular Oxidoreductases, Male, Mice, Osteoarthritis, Age Factors, Animals, Humans, Macrophage Migration-Inhibitory Factors, Severity of Illness Index, Article, Cells, Cultured, Gene Deletion
Abstract

Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that is elevated in the serum and synovial fluid of patients with osteoarthritis (OA). This study was undertaken to investigate the potential role of MIF in OA in human joint tissues and in vivo in mice with age-related and surgically induced OA.MIF in conditioned media from human chondrocytes and meniscal cells and from cartilage explants was measured by enzyme-linked immunosorbent assay. The severity of OA was analyzed histologically in male wild-type and MIFHuman OA chondrocytes secreted 3-fold higher levels of MIF than normal chondrocytes, while normal and OA meniscal cells produced equivalent amounts. Compared to age- and strain-matched controls, the cartilage, bone, and synovium in older adult mice with MIF deletion were protected against changes of naturally occurring age-related OA. No protection against DMM-induced OA was seen in young adult MIFThese results demonstrate a differential mechanism in the pathogenesis of naturally occurring age-related OA compared to injury-induced OA. The inhibition of MIF may represent a novel therapeutic target in the reduction of the severity of age-related OA.

Published
2017

22. A Role for Macrophage Migration Inhibitory Factor in the Neonatal Respiratory Distress Syndrome

Author

Kevill, Katharine A., primary, Bhandari, Vineet, additional, Kettunen, Mika, additional, Leng, Lin, additional, Fan, Juan, additional, Mizue, Yuka, additional, Dzuira, James D., additional, Reyes-Mugica, Miguel, additional, McDonald, Courtney L., additional, Baugh, John A., additional, O’Connor, Christine L., additional, Aghai, Zubair H., additional, Donnelly, Seamas C., additional, Bazzy-Asaad, Alia, additional, and Bucala, Richard J., additional

Published
2008
Full Text
View/download PDF

23. Editorial: A Fresh New Look, and a Fresh New Journal.

Author

Bucala, Richard J. and Hannan, Marian T.

Subjects
*AUTOANTIBODIES, *LYMPHOCYTES, *MEDICAL practice, *MEDICAL research, *QUALITY assurance, *RHEUMATOID arthritis, *RHEUMATOLOGY, *HEALTH literacy
Abstract

An introduction is presented in which the author talks about immunologic abnormalities in patients with rheumatoid arthritis, scope of clinical medicine, and the impact of biomedical research on clinical practice.

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results