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Your search keyword '"Bubenik, Monica"' showing total 17 results
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17 results on '"Bubenik, Monica"'

1. Identification of RP-6685, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ

Author

Bubenik, Monica, primary, Mader, Pavel, additional, Mochirian, Philippe, additional, Vallée, Fréderic, additional, Clark, Jillian, additional, Truchon, Jean-François, additional, Perryman, Alexander L., additional, Pau, Victor, additional, Kurinov, Igor, additional, Zahn, Karl E., additional, Leclaire, Marie-Eve, additional, Papp, Robert, additional, Mathieu, Marie-Claude, additional, Hamel, Martine, additional, Duffy, Nicole M., additional, Godbout, Claude, additional, Casas-Selves, Matias, additional, Falgueyret, Jean-Pierre, additional, Baruah, Prasamit S., additional, Nicolas, Olivier, additional, Stocco, Rino, additional, Poirier, Hugo, additional, Martino, Giovanni, additional, Fortin, Alexanne Bonneau, additional, Roulston, Anne, additional, Chefson, Amandine, additional, Dorich, Stéphane, additional, St-Onge, Miguel, additional, Patel, Purvish, additional, Pellerin, Charles, additional, Ciblat, Stéphane, additional, Pinter, Thomas, additional, Barabé, Francis, additional, El Bakkouri, Majida, additional, Parikh, Paranjay, additional, Gervais, Christian, additional, Sfeir, Agnel, additional, Mamane, Yael, additional, Morris, Stephen J., additional, Black, W. Cameron, additional, Sicheri, Frank, additional, and Gallant, Michel, additional

Published
2022
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2. Tetranuclear, hexanuclear, and octanuclear copper(II) complexes of a series of novel dendritic poly(phthalazine) ligands

Author

Zhang, Yisheng, Thompson, Laurence K., Bridson, John N., and Bubenik, Monica

Subjects
Ligands -- Research, Molecular structure -- Observations, Copper compounds -- Research, Complex compounds -- Research, Chemistry
Abstract

A series of polynucleating, poly(aminophthalazine) ligands with two, three, and four connected phthalazine groups has been synthesized. The reaction of these ligands with copper salts yields tetranuclear, hexanuclear, and octanuclear derivatives. The study indicates that the (pyridylamino)-phthalazine groups consists of a nanometer sized tetranuclear and octanuclear arrays of antiferromagnetically coupled, hydroxo-bridged, dinuclear copper(II) centers.

Published
1995

3. Synthesis and structural and magnetic properties of mononuclear, dinuclear, and tetranuclear copper(II) complexes of a 17-membered macrocyclic ligand (HM3), capable of forming endogenous phenoxide and pyridazino bridges: X-ray crystal structures of (Cu2(M3)(mu2-OMe)(NO3)2), (Cu4(M3)2(mu3-OMe)2(mu2-Cl)2Cl2), (Cu4(M3)2(mu3-OEt)2(mu2-N3)2)(MeOH), (Cu4(M3)2(mu3-OMe)2(NCS)4)(DMF), and (Cu(M3))

Author

Tandon, Santokh S., Thompson, Laurence K., Bridson, John N., and Bubenik, Monica

Subjects
Coordination compounds -- Analysis, Copper compounds -- Analysis, Ligands -- Analysis, Chemistry
Abstract

A binuclear copper(II) complex of the 17-membered macrocyclic ligand HM3 is formed by template condensation of 2,6-diformyl-4-methylphenol with PTA in the presence of copper(II) nitrate and trifluoromethanesulfonate. Cu2(M3)(mu2-OMe)(NO3)2 produces tetranuclear Cu(II) derivatives on treatment with chloride, azide, thiocyanate and bromide. Cu(II) complexes have phenoxide and methoxide bridges between the two Cu centers, and exhibit antiferromagnetic coupling properties.

Published
1993

4. Benzimidazole-containing HCV NS5A inhibitors: Effect of 4-substituted pyrrolidines in balancing genotype 1a and 1b potency

Author

Henderson, James A., Bilimoria, Darius, Bubenik, Monica, Cadilhac, Caroline, Cottrell, Kevin M., Dietrich, Evelyne, Denis, Francois, Ewing, Nigel, Falardeau, Guy, Giroux, Simon, Grey, Ronald, Jr., L’Heureux, Lucille, Liu, Bingcan, Mani, Nagraj, Morris, Mark, Nicolas, Olivier, Pereira, Oswy Z., Poisson, Carl, Govinda Rao, B., Reddy, T. Jagadeeswar, Selliah, Subajini, Shawgo, Rebecca S., Vaillancourt, Louis, Wang, Jian, Yannopoulos, Constantin G., Chauret, Nathalie, Berlioz-Seux, Francoise, Chan, Laval C., Das, Sanjoy K., Grillot, Anne-Laure, Bennani, Youssef L., and Maxwell, John P.

Published
2015
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5. Synthesis and evaluation of NS5A inhibitors containing diverse heteroaromatic cores

Author

Henderson, James A., Bilimoria, Darius, Bubenik, Monica, Cadilhac, Caroline, Cottrell, Kevin M., Denis, Francois, Dietrich, Evelyne, Ewing, Nigel, Falardeau, Guy, Giroux, Simon, L’Heureux, Lucille, Liu, Bingcan, Mani, Nagraj, Morris, Mark, Nicolas, Olivier, Pereira, Oswy Z., Poisson, Carl, Reddy, T. Jagadeeswar, Selliah, Subajini, Shawgo, Rebecca S., Vaillancourt, Louis, Wang, Jian, Xu, Jinwang, Chauret, Nathalie, Berlioz-Seux, Francoise, Chan, Laval C., Das, Sanjoy K., Grillot, Anne-Laure, Bennani, Youssef L., and Maxwell, John P.

Published
2015
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7. Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based HTS assay. Part 5: Modifications of the 2- and 3-positions

Author

Kemnitzer, William, primary, Jiang, Songchun, additional, Wang, Yan, additional, Kasibhatla, Shailaja, additional, Crogan-Grundy, Candace, additional, Bubenik, Monica, additional, Labrecque, Denis, additional, Denis, Real, additional, Lamothe, Serge, additional, Attardo, Giorgio, additional, Gourdeau, Henriette, additional, Tseng, Ben, additional, Drewe, John, additional, and Cai, Sui Xiong, additional

Published
2008
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17. A novel RGD antagonist that targets both alphavbeta3 and alpha5beta1 induces apoptosis of angiogenic endothelial cells on type I collagen.

Author

Meerovitch K, Bergeron F, Leblond L, Grouix B, Poirier C, Bubenik M, Chan L, Gourdeau H, Bowlin T, and Attardo G

Subjects
Anoikis, Cell Adhesion, Cell Division drug effects, Cell Line, Cell Line, Tumor, Cell Survival drug effects, Endothelium, Vascular cytology, Extracellular Matrix physiology, Guanidines chemistry, Humans, Integrin alpha5beta1 physiology, Integrin alphaVbeta3 physiology, Intercellular Signaling Peptides and Proteins, Molecular Mimicry, Neovascularization, Pathologic pathology, Peptides pharmacology, Receptors, Immunologic, Sulfonamides chemistry, Vitronectin metabolism, Apoptosis, Collagen Type I metabolism, Endothelium, Vascular drug effects, Guanidines pharmacology, Integrin alpha5beta1 antagonists & inhibitors, Integrin alphaVbeta3 antagonists & inhibitors, Oligopeptides chemistry, Sulfonamides pharmacology
Abstract

Integrin-mediated cell adhesion is necessary for endothelial cell proliferation and apoptosis, which is a major determinant in tumor-induced angiogenesis. In this study, we compared two novel, structurally similar, Arg-Gly-Asp (RGD) peptidomimetic compounds having different integrin selectivities, for their inhibition of endothelial cell proliferation and induction of apoptosis on functionally relevant extracellular matrices (ECM) for angiogenesis. BCH-14661 was specific for integrin alphavbeta3, whereas BCH-15046 nonselectively antagonized integrins alphavbeta3, alphavbeta5, and alpha5beta1. Both compounds were potent inducers of endothelial cell apoptosis when plated on RGD-dependent ECM (vitronectin, VN), which was dependent on the ability to induce cell detachment. However, with endothelial cells plated on RGD-independent ECM (type I collagen, COL), only BCH-15046 was able to significantly prevent growth and induce apoptosis. This effect was not dependent on the induction of detachment. Experiments using the matrix metalloproteinase (MMP) inhibitor GM 6001 revealed that cleavage of COL was not required for the ability of BCH-15046 to induce apoptosis. However, the inhibition of growth factor-stimulated endothelial cell proliferation, required MMPs, and correlated with BCH-15046s' potent inhibition of endothelial cell attachment to denatured collagen. Antibody inhibition experiments showed that adhesion to denatured collagen required integrins alphavbeta3 and beta1, but not alphavbeta5. In addition, BCH-15046 exerted a significant inhibition of VEGF-stimulated angiogenesis in the chick chorioallontoic membrane in vivo. These results suggest that integrin antagonism of both alphavbeta3 and alpha5beta1 are important for MMP-independent induction of apoptosis on COL and MMP-dependent inhibition of endothelial cell-denatured collagen interactions required for proliferation.

Published
2003
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